Brian Finan

Brian Finan

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Brian Finan

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Corrigendum to "Pirt deficiency has subtle female-specific effects on energy and glucose metabolism in mice" [Molecular Metabolism 23 (2019) 75-81].

Mol Metab 2019 Dec;30:264

Institute for Diabetes and Obesity, Helmholtz Diabetes Center at Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), 85764, Neuherberg, Germany; German Center for Diabetes Research (DZD), 85764, Neuherberg, Germany; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2200, Copenhagen N, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.molmet.2019.11.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6889306PMC
December 2019

Glucagon-Receptor Signaling Reverses Hepatic Steatosis Independent of Leptin Receptor Expression.

Endocrinology 2019 Nov 1. Epub 2019 Nov 1.

Comprehensive Diabetes Center and Department of Medicine - Division of Endocrinology, Diabetes and Metabolism, University of Alabama at Birmingham, Birmingham, AL USA.

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http://dx.doi.org/10.1210/endocr/bqz013DOI Listing
November 2019

Selection and progression of unimolecular agonists at the GIP, GLP-1, and glucagon receptors as drug candidates.

Peptides 2019 Nov 28:170225. Epub 2019 Nov 28.

Novo Nordisk Research Center Indianapolis, Indianapolis, IN, USA; Department of Chemistry, Indiana University, Bloomington, IN, USA. Electronic address:

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http://dx.doi.org/10.1016/j.peptides.2019.170225DOI Listing
November 2019

Insulin-like peptide 5 fails to improve metabolism or body weight in obese mice.

Peptides 2019 10 23;120:170116. Epub 2019 Jul 23.

Novo Nordisk Research Center, Indianapolis, IN, 46241, USA.

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http://dx.doi.org/10.1016/j.peptides.2019.170116DOI Listing
October 2019

A Disulfide Scan of Insulin by [3 + 1] Methodology Exhibits Site-Specific Influence on Bioactivity.

ACS Chem Biol 2019 08 6;14(8):1829-1835. Epub 2019 Aug 6.

Novo Nordisk Research Center , Indianapolis , Indiana 46241 , United States.

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http://dx.doi.org/10.1021/acschembio.9b00420DOI Listing
August 2019

GLP-1/dexamethasone inhibits food reward without inducing mood and memory deficits in mice.

Neuropharmacology 2019 06 1;151:55-63. Epub 2019 Apr 1.

Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.neuropharm.2019.03.035DOI Listing
June 2019

Repositioning Glucagon Action in the Physiology and Pharmacology of Diabetes.

Diabetes 2019 Jun 9. Epub 2019 Jun 9.

Department of Medicine, Division of Endocrinology, Duke University, Durham, NC, USA

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http://dx.doi.org/10.2337/dbi19-0004DOI Listing
June 2019

Pirt deficiency has subtle female-specific effects on energy and glucose metabolism in mice.

Mol Metab 2019 05 7;23:75-81. Epub 2019 Mar 7.

Institute for Diabetes and Obesity, Helmholtz Diabetes Center at Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), 85764 Neuherberg, Germany; German Center for Diabetes Research (DZD), 85764 Neuherberg, Germany; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2200 Copenhagen N, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.molmet.2019.02.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6479763PMC
May 2019

Peptide Conjugates with Small Molecules Designed to Enhance Efficacy and Safety.

Molecules 2019 May 14;24(10). Epub 2019 May 14.

Novo Nordisk Research Center, Indianapolis, IN 46241, USA.

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http://dx.doi.org/10.3390/molecules24101855DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6572008PMC
May 2019

Emerging hormonal-based combination pharmacotherapies for the treatment of metabolic diseases.

Nat Rev Endocrinol 2019 02;15(2):90-104

Institute for Diabetes and Regeneration, Helmholtz Diabetes Center, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Neuherberg, Germany.

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http://www.nature.com/articles/s41574-018-0118-x
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http://dx.doi.org/10.1038/s41574-018-0118-xDOI Listing
February 2019

Optimized GIP analogs promote body weight lowering in mice through GIPR agonism not antagonism.

Mol Metab 2019 02 5;20:51-62. Epub 2018 Dec 5.

Department of Internal Medicine, University of Cincinnati-College of Medicine, Cincinnati, OH, 45267, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22128778183110
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http://dx.doi.org/10.1016/j.molmet.2018.12.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358549PMC
February 2019

An incretin-based tri-agonist promotes superior insulin secretion from murine pancreatic islets via PLC activation.

Cell Signal 2018 11 25;51:13-22. Epub 2018 Jul 25.

Institute of Experimental Pediatric Endocrinology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.

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http://dx.doi.org/10.1016/j.cellsig.2018.07.006DOI Listing
November 2018

Targeting the Incretin/Glucagon System With Triagonists to Treat Diabetes.

Endocr Rev 2018 10;39(5):719-738

Duke Molecular Physiology Institute, Duke University, Durham, North Carolina.

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http://dx.doi.org/10.1210/er.2018-00117DOI Listing
October 2018

Clearance kinetics of the VGF-derived neuropeptide TLQP-21.

Neuropeptides 2018 Oct 19;71:97-103. Epub 2018 Jun 19.

Department of Integrative Biology and Physiology, University of Minnesota, Minneapolis, MN 55455, USA. Electronic address:

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http://dx.doi.org/10.1016/j.npep.2018.06.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6166661PMC
October 2018

Metabolic syndrome and extensive adipose tissue inflammation in morbidly obese Göttingen minipigs.

Mol Metab 2018 10 28;16:180-190. Epub 2018 Jun 28.

Chair for Molecular Animal Breeding and Biotechnology, Gene Center and Department of Veterinary Sciences, LMU Munich, Feodor-Lynen-Str. 25, 81377, Munich, Germany; Center for Innovative Medical Models (CiMM), Department of Veterinary Sciences, LMU Munich, Hackerstr. 27, 85764, Oberschleißheim, Germany; German Center for Diabetes Research (DZD), Ingolstädter Landstr. 1, 85764, Neuherberg, Germany; Laboratory for Functional Genome Analysis (LAFUGA), Gene Center, LMU Munich, Feodor-Lynen-Str. 25, 81377, Munich, Germany.

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http://dx.doi.org/10.1016/j.molmet.2018.06.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6157610PMC
October 2018

Glucagon Receptor Signaling Regulates Energy Metabolism via Hepatic Farnesoid X Receptor and Fibroblast Growth Factor 21.

Diabetes 2018 09 20;67(9):1773-1782. Epub 2018 Jun 20.

Comprehensive Diabetes Center and Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL

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http://dx.doi.org/10.2337/db17-1502DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6110317PMC
September 2018

Molecular elements in FGF19 and FGF21 defining KLB/FGFR activity and specificity.

Mol Metab 2018 07 11;13:45-55. Epub 2018 May 11.

Department of Chemistry, Indiana University, Bloomington, IN, 47405, USA; Interdisciplinary Biochemistry Graduate Program, Indiana University, Bloomington, IN, 47405, USA; Novo Nordisk Research Center Indianapolis, Indianapolis, IN, 46241, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molmet.2018.05.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026317PMC
July 2018

Optimization of peptide-based polyagonists for treatment of diabetes and obesity.

Bioorg Med Chem 2018 06 2;26(10):2873-2881. Epub 2017 Nov 2.

Novo Nordisk Research Center Indianapolis, Indianapolis, IN, USA; Department of Chemistry, Indiana University, Bloomington, IN, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2017.10.047DOI Listing
June 2018

Molecular Integration of Incretin and Glucocorticoid Action Reverses Immunometabolic Dysfunction and Obesity.

Cell Metab 2017 Oct 21;26(4):620-632.e6. Epub 2017 Sep 21.

Institute for Diabetes and Obesity, Helmholtz Diabetes Center, Helmholtz Zentrum München, 85764 Neuherberg, Germany; Division of Metabolic Diseases, Department of Medicine, Technische Universität München, 80333 Munich, Germany; German Center for Diabetes Research (DZD), Helmholtz Zentrum München, Ingolstädter Landstraße, 85764 Neuherberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2017.08.023DOI Listing
October 2017

Monomeric GLP-1/GIP/glucagon triagonism corrects obesity, hepatosteatosis, and dyslipidemia in female mice.

Mol Metab 2017 05 1;6(5):440-446. Epub 2017 Mar 1.

German Center for Diabetes Research (DZD), 85764 Neuherberg, Germany; Institute for Diabetes and Regeneration, Helmholtz Diabetes Center at Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), 85764 Neuherberg, Germany; Medizinische Klinik und Poliklinik IV, Klinikum der LMU, 80336 München, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.molmet.2017.02.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5404097PMC
May 2017

GLP-1 and estrogen conjugate acts in the supramammillary nucleus to reduce food-reward and body weight.

Neuropharmacology 2016 11 2;110(Pt A):396-406. Epub 2016 Aug 2.

Department of Physiology/Metabolic Physiology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, SE-405 30, Gothenburg, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.neuropharm.2016.07.039DOI Listing
November 2016

Determination of thyroid hormones in mouse tissues by isotope-dilution microflow liquid chromatography-mass spectrometry method.

J Chromatogr B Analyt Technol Biomed Life Sci 2016 Oct 26;1033-1034:413-420. Epub 2016 Aug 26.

Helmholtz Zentrum München - German Research Center for Environmental Health (GmbH), Molecular EXposomics, Ingolstädter Landstr. 1, 85764, Neuherberg, Germany; Technische Universität München, Wissenschaftszentrum Weihenstephan für Ernährung, Landnutzung und Umwelt, Department für Biowissenschaften, Weihenstephaner Steig 23, 85350 Freising, Germany.

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http://dx.doi.org/10.1016/j.jchromb.2016.08.037DOI Listing
October 2016

Unimolecular Polypharmacy for Treatment of Diabetes and Obesity.

Cell Metab 2016 07;24(1):51-62

Department of Chemistry, Indiana University, Bloomington, IN 47405, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2016.06.021DOI Listing
July 2016

Current and Emerging Treatment Options in Diabetes Care.

Handb Exp Pharmacol 2016 ;233:437-59

Department of Chemistry, Indiana University, Bloomington, IN, USA.

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http://dx.doi.org/10.1007/164_2015_7DOI Listing
June 2016

Reappraisal of GIP Pharmacology for Metabolic Diseases.

Trends Mol Med 2016 05 30;22(5):359-376. Epub 2016 Mar 30.

Institute for Diabetes and Obesity, Helmholtz Diabetes Center at Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Neuherberg, Germany; Division of Metabolic Diseases, Department of Medicine, Technische Universität München, Munich, Germany; German Center for Diabetes Research (DZD), Neuherberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.molmed.2016.03.005DOI Listing
May 2016

Emerging opportunities for the treatment of metabolic diseases: Glucagon-like peptide-1 based multi-agonists.

Mol Cell Endocrinol 2015 Dec 4;418 Pt 1:42-54. Epub 2015 Jul 4.

Institute for Diabetes and Obesity, Helmholtz Diabetes Center at Helmholtz Zentrum München, Neuherberg, Germany; Division of Metabolic Diseases, Department of Medicine, Technische Universität München, Munich, Germany.

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http://dx.doi.org/10.1016/j.mce.2015.07.003DOI Listing
December 2015

The Pentapeptide RM-131 Promotes Food Intake and Adiposity in Wildtype Mice but Not in Mice Lacking the Ghrelin Receptor.

Front Nutr 2014 12;1:31. Epub 2015 Jan 12.

Institute for Diabetes and Obesity (IDO) and Helmholtz Diabetes Center, Helmholtz Center Munich, German Research Center for Environmental Health (GmbH) , Neuherberg , Germany ; Division of Metabolic Diseases, Department of Medicine, Technische Universität München , Munich , Germany.

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http://dx.doi.org/10.3389/fnut.2014.00031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4428373PMC
May 2015

GLP-1-oestrogen attenuates hyperphagia and protects from beta cell failure in diabetes-prone New Zealand obese (NZO) mice.

Diabetologia 2015 Mar 20;58(3):604-14. Epub 2014 Dec 20.

Department of Experimental Diabetology, German Institute of Human Nutrition Potsdam-Rehbruecke, Arthur-Scheunert-Allee 114-116, 14558, Nuthetal, Germany,

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http://dx.doi.org/10.1007/s00125-014-3478-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4320309PMC
March 2015

Dual melanocortin-4 receptor and GLP-1 receptor agonism amplifies metabolic benefits in diet-induced obese mice.

EMBO Mol Med 2015 Mar;7(3):288-98

Institute for Diabetes and Obesity & Helmholtz Diabetes Center, Helmholtz Zentrum München German Research Center for Environmental Health (GmbH), Neuherberg, Germany Division of Metabolic Diseases, Department of Medicine, Technische Universität München, Munich, Germany

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http://dx.doi.org/10.15252/emmm.201404508DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4364946PMC
March 2015

Hypothalamic PGC-1α protects against high-fat diet exposure by regulating ERα.

Cell Rep 2014 Oct 16;9(2):633-45. Epub 2014 Oct 16.

Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390-8857, USA; Department of Biomedical Research, Diabetes and Obesity Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2014.09.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4223650PMC
October 2014

Sirtuin 1 and sirtuin 3: physiological modulators of metabolism.

Physiol Rev 2012 Jul;92(3):1479-514

Department of Physiology, School of Medicine-Instituto de Investigaciones Sanitarias, University of Santiago de Compostela, Santiago de Compostela, Spain.

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http://dx.doi.org/10.1152/physrev.00022.2011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3746174PMC
July 2012