Brian Dean

Brian Dean

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Brian Dean

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Changed cortical risk gene expression in major depression and shared changes in cortical gene expression between major depression and bipolar disorders.

Aust N Z J Psychiatry 2019 Dec 25;53(12):1189-1198. Epub 2019 Jun 25.

Molecular Psychiatry Laboratory, Florey Institute of Neuroscience and Mental Health, Parkville, VIC, Australia.

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http://dx.doi.org/10.1177/0004867419857808DOI Listing
December 2019

Altered levels of dopamine transporter in the frontal pole and dorsal striatum in schizophrenia.

NPJ Schizophr 2019 Dec 2;5(1):20. Epub 2019 Dec 2.

The Florey Institute of Neuroscience and Mental Health, Parkville, VIC, Australia.

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http://dx.doi.org/10.1038/s41537-019-0087-7DOI Listing
December 2019

Widespread Changes in Positive Allosteric Modulation of the Muscarinic M1 Receptor in Some Participants With Schizophrenia.

Int J Neuropsychopharmacol 2019 Oct;22(10):640-650

The Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia.

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http://dx.doi.org/10.1093/ijnp/pyz045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6822142PMC
October 2019

Supercritical fluid chromatography-tandem mass spectrometry for high throughput bioanalysis of small molecules in drug discovery.

J Pharm Biomed Anal 2019 Feb 13;164:62-69. Epub 2018 Oct 13.

Genentech, Inc., Drug Metabolism and Pharmacokinetics, MS 412A, 1 DNA Way, South San Francisco, CA, 94080, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S07317085183141
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http://dx.doi.org/10.1016/j.jpba.2018.10.021DOI Listing
February 2019

Supercritical fluid chromatography-tandem mass spectrometry for high throughput bioanalysis of small molecules in drug discovery.

J Pharm Biomed Anal 2019 Feb 13;164:62-69. Epub 2018 Oct 13.

Genentech, Inc., Drug Metabolism and Pharmacokinetics, MS 412A, 1 DNA Way, South San Francisco, CA, 94080, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S07317085183141
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http://dx.doi.org/10.1016/j.jpba.2018.10.021DOI Listing
February 2019

Differential effects of chronic 17β-oestradiol treatment on rat behaviours relevant to depression.

J Neuroendocrinol 2018 11 13;30(11):e12652. Epub 2018 Nov 13.

The Florey Institute of Neuroscience and Mental Health, Parkville, VIC, Australia.

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http://dx.doi.org/10.1111/jne.12652DOI Listing
November 2018

Β-actin does not show the characteristics of a reference protein in human cortex.

Electrophoresis 2019 01 6;40(2):247-253. Epub 2018 Nov 6.

The Molecular Psychiatry Laboratory, the Florey Institute for Neuroscience and Mental Health, Parkville, Victoria, Australia.

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http://doi.wiley.com/10.1002/elps.201800328
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http://dx.doi.org/10.1002/elps.201800328DOI Listing
January 2019

mRNA expression of the P5 ATPase ATP13A4 is increased in Broca's Area from subjects with schizophrenia.

World J Biol Psychiatry 2018 Dec 3:1-23. Epub 2018 Dec 3.

a The Florey Institute for Neuroscience and Mental Health , Parkville , Victoria 3052 , Australia.

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http://dx.doi.org/10.1080/15622975.2018.1548781DOI Listing
December 2018

Evaluation of polysaccharide-based chiral stationary phases in modern SFC-MS/MS for enantioselective bioanalysis.

Bioanalysis 2019 Jan 23. Epub 2019 Jan 23.

Drug Metabolism & Pharmacokinetics, Genentech Inc. 1 DNA Way, South San Francisco, CA 94080, USA.

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https://www.future-science.com/doi/10.4155/bio-2018-0168
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http://dx.doi.org/10.4155/bio-2018-0168DOI Listing
January 2019

Catechol-O-methyltransferase (COMT) genotypes are associated with varying soluble, but not membrane-bound COMT protein in the human prefrontal cortex.

J Hum Genet 2018 Dec 14;63(12):1251-1258. Epub 2018 Sep 14.

Molecular Psychiatry Laboratories, The Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia.

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http://www.nature.com/articles/s10038-018-0511-2
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http://dx.doi.org/10.1038/s10038-018-0511-2DOI Listing
December 2018

mRNA expression of the P5 ATPase ATP13A4 is increased in Broca's Area from subjects with schizophrenia.

World J Biol Psychiatry 2018 Dec 3:1-23. Epub 2018 Dec 3.

a The Florey Institute for Neuroscience and Mental Health , Parkville , Victoria 3052 , Australia.

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http://dx.doi.org/10.1080/15622975.2018.1548781DOI Listing
December 2018

Differential effects of chronic 17β-oestradiol treatment on rat behaviours relevant to depression.

J Neuroendocrinol 2018 11 13;30(11):e12652. Epub 2018 Nov 13.

The Florey Institute of Neuroscience and Mental Health, Parkville, VIC, Australia.

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http://dx.doi.org/10.1111/jne.12652DOI Listing
November 2018

Epigenetic Aging in Major Depressive Disorder.

Am J Psychiatry 2018 08 16;175(8):774-782. Epub 2018 Apr 16.

From the Department of Psychiatry, VU University Medical Center, Amsterdam Neuroscience, GGZ inGeest, the Amsterdam Public Health Research Institute, Amsterdam; the Center for Biomarker Research and Precision Medicine, School of Pharmacy, Virginia Commonwealth University, Richmond; the Molecular Psychiatry Laboratory, Florey Department of Neuroscience and Mental Health, Melbourne, Australia; and the Centre for Mental Health, Faculty of Health, Arts, and Design, Swinburne University, Hawthorne, Australia.

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http://dx.doi.org/10.1176/appi.ajp.2018.17060595DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6094380PMC
August 2018

Low levels of muscarinic M1 receptor-positive neurons in cortical layers III and V in Brodmann areas 9 and 17 from individuals with schizophrenia.

J Psychiatry Neurosci 2018 08;43(5):338-346

From the Molecular Psychiatry Laboratory, University of Melbourne, Victoria, Australia (Scarr, Hopper, Vos, Suk Seo, Dean); the Midbrain Dopamine Plasticity Laboratory, the Florey Institute of Neuroscience and Mental Health, University of Melbourne, Victoria, Australia (Aumann); the Centre for Mental Health, Faculty of Health, Arts and Design, Swinburne University, Victoria, Australia (Dean); the Department of Psychiatry, University of Melbourne, Victoria, Australia (Everall); the Integrative Biological Psychiatry Laboratory, Centre for Neural Engineering, University of Melbourne, Victoria, Australia (Chana); and the Melbourne Veterinary School, Faculty of Veterinary and Agricultural Sciences, University of Melbourne, Victoria, Australia (Scarr).

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158028PMC
August 2018

Definitive profiling of plasma bile acids as potential biomarkers for human liver diseases using UPLC-HRMS.

Bioanalysis 2018 Jun;10(12):917-932

Drug Metabolism & Pharmacokinetics, Genentech, 1 DNA way, South San Francisco, CA 94080, USA.

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http://dx.doi.org/10.4155/bio-2018-0018DOI Listing
June 2018

Glutamate transporters, EAAT1 and EAAT2, are potentially important in the pathophysiology and treatment of schizophrenia and affective disorders.

World J Psychiatry 2018 Jun 28;8(2):51-63. Epub 2018 Jun 28.

Molecular Psychiatry Laboratory, the Florey Institute of Neuroscience and Mental Health, Parkville VIC 3052, Australia.

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http://dx.doi.org/10.5498/wjp.v8.i2.51DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6033743PMC
June 2018

Low levels of muscarinic M1 receptor-positive neurons in cortical layers III and V in Brodmann areas 9 and 17 from individuals with schizophrenia.

J Psychiatry Neurosci 2018 05 30;43(4):170202. Epub 2018 May 30.

From the Molecular Psychiatry Laboratory, University of Melbourne, Victoria, Australia (Scarr, Hopper, Vos, Suk Seo, Dean); the Midbrain Dopamine Plasticity Laboratory, the Florey Institute of Neuroscience and Mental Health, University of Melbourne, Victoria, Australia (Aumann); the Centre for Mental Health, Faculty of Health, Arts and Design, Swinburne University, Victoria, Australia (Dean); the Department of Psychiatry, University of Melbourne, Victoria, Australia (Everall); the Integrative Biological Psychiatry Laboratory, Centre for Neural Engineering, University of Melbourne, Victoria, Australia (Chunam); and the Melbourne Veterinary School, Faculty of Veterinary and Agricultural Sciences, University of Melbourne, Victoria, Australia (Scarr).

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http://dx.doi.org/10.1503/jpn.170202DOI Listing
May 2018

Non-Coding RNA as Novel Players in the Pathophysiology of Schizophrenia.

Noncoding RNA 2018 Apr 12;4(2). Epub 2018 Apr 12.

The Florey Institute for Neuroscience and Mental Health, 30 Royal Parade, Parkville, VIC 3052, Australia.

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http://dx.doi.org/10.3390/ncrna4020011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6027250PMC
April 2018

Changed frontal pole gene expression suggest altered interplay between neurotransmitter, developmental, and inflammatory pathways in schizophrenia.

NPJ Schizophr 2018 Feb 20;4(1). Epub 2018 Feb 20.

Molecular Psychiatry Laboratory, Florey Institute for Neuroscience and Mental Health, Parkville, VIC 3052, Australia.

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http://dx.doi.org/10.1038/s41537-018-0044-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5820249PMC
February 2018

Irreproducible data: Problems and solutions for psychiatry.

Authors:
Brian Dean

Aust N Z J Psychiatry 2018 01 6;52(1):10-12. Epub 2017 Nov 6.

1 Molecular Psychiatry Laboratory, The Florey Institute of Neuroscience & Mental Health, Parkville, VIC, Australia.

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http://dx.doi.org/10.1177/0004867417741558DOI Listing
January 2018

The Cholinergic System: An Emerging Drug Target for Schizophrenia.

Curr Pharm Des 2016 ;22(14):2124-33

The Florey Institute of Neuroscience and Mental Health, 30 Royal Parade, Parkville, Victoria 3052, Australia.

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http://dx.doi.org/10.2174/1381612822666160127114010DOI Listing
November 2017

Strategy for CYP3A Induction Risk Assessment from Preclinical Signal to Human: a Case Example of a Late-Stage Discovery Compound.

Pharm Res 2017 Nov 16;34(11):2403-2414. Epub 2017 Aug 16.

Department of Drug Metabolism and Pharmacokinetics, Genentech, A Member of the Roche Group, 1 DNA Way, South San Francisco, California, 94080, USA.

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http://dx.doi.org/10.1007/s11095-017-2246-8DOI Listing
November 2017

Interictal epileptiform discharge characteristics underlying expert interrater agreement.

Clin Neurophysiol 2017 10 18;128(10):1994-2005. Epub 2017 Jul 18.

Department of Neurology, Medical University of South Carolina, Charleston, SC, USA. Electronic address:

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http://dx.doi.org/10.1016/j.clinph.2017.06.252DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5842710PMC
October 2017

Strategies of Drug Transporter Quantitation by LC-MS: Importance of Peptide Selection and Digestion Efficiency.

AAPS J 2017 09 6;19(5):1469-1478. Epub 2017 Jun 6.

Genentech Inc, 1 DNA Way, South San Francisco, California, 94080, USA.

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http://dx.doi.org/10.1208/s12248-017-0106-4DOI Listing
September 2017

A multi-matrix HILIC-MS/MS method for the quantitation of endogenous small molecule neurological biomarker N-acetyl aspartic acid (NAA).

J Pharm Biomed Anal 2017 Jun 14;140:11-19. Epub 2017 Mar 14.

Genentech, Drug Metabolism and Pharmacokinetics, 1 DNA Way, South San Francisco, CA 94080, United States.

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http://dx.doi.org/10.1016/j.jpba.2017.03.020DOI Listing
June 2017

Characteristics of EEG Interpreters Associated With Higher Interrater Agreement.

J Clin Neurophysiol 2017 Mar;34(2):168-173

*Department of Neurology, Medical University of South Carolina, Charleston, South Carolina, U.S.A.; †Department of Neurology, Vanderbilt University, Nashville, Tennessee, U.S.A.; ‡Department of Neurology, University of Texas Health Science Center of Huston, Huston, Texas, U.S.A.; §Mission Health, Asheville, North Carolina, U.S.A.; ‖Department of Neurology, Wayne State University and Detroit Medical Center, Detroit, Michigan, U.S.A.; ¶Academic Health System, Hamad Medical Corporation, Doha, Qatar; #Norton Neurology Services, Louisville, Kentucky, U.S.A.; **Department of Public Health Sciences, Medical University of South Carolina, Charleston, South Carolina, U.S.A.; and ††School of Computing, Clemson University, Clemson, South Carolina, U.S.A.

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http://dx.doi.org/10.1097/WNP.0000000000000344DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5784780PMC
March 2017

Higher levels of different muscarinic receptors in the cortex and hippocampus from subjects with Alzheimer's disease.

J Neural Transm (Vienna) 2017 03 29;124(3):273-284. Epub 2016 Sep 29.

Molecular Psychiatry Laboratory, Division of Biological Psychiatry and Mental Health, Florey Institute for Neuroscience and Mental Health, 30 Royal Parade, Parkville, VIC, 3052, Australia.

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http://dx.doi.org/10.1007/s00702-016-1625-3DOI Listing
March 2017

Muscarinic receptor binding changes in postmortem Parkinson's disease.

J Neural Transm (Vienna) 2017 02 21;124(2):227-236. Epub 2016 Nov 21.

The Florey Institute for Neuroscience and Mental Health, Melbourne, VIC, Australia.

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http://dx.doi.org/10.1007/s00702-016-1629-zDOI Listing
February 2017

Development of a multi-matrix LC-MS/MS method for urea quantitation and its application in human respiratory disease studies.

J Pharm Biomed Anal 2017 Jan 2;133:96-104. Epub 2016 Nov 2.

Department of Drug Metabolism and Pharmacokinetics, Genentech Inc., South San Francisco, CA 94080, USA.

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http://dx.doi.org/10.1016/j.jpba.2016.11.001DOI Listing
January 2017

A supported liquid extraction LC-MS/MS method for determination of concentrations of GDC-0425, a small molecule Checkpoint kinase 1 inhibitor, in human plasma.

Biomed Chromatogr 2016 Dec 5;30(12):1984-1991. Epub 2016 Jul 5.

Genentech, Drug Metabolism and Pharmacokinetics, 1 DNA Way, South San Francisco, CA, USA.

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http://dx.doi.org/10.1002/bmc.3775DOI Listing
December 2016

Comparison of a Novel Dry Electrode Headset to Standard Routine EEG in Veterans.

J Clin Neurophysiol 2016 Dec;33(6):530-537

*Department of Neurology, Medical University of South Carolina, Charleston, South Carolina, U.S.A.; †Department of Neurology, Ralph H. Johnson Veterans Medical Center, Charleston, South Carolina, U.S.A.; ‡Department of Electrical and Computer Engineering, Clemson University, Clemson, South Carolina, U.S.A.; and §School of Computing, Clemson University, Clemson, South Carolina, U.S.A.

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http://dx.doi.org/10.1097/WNP.0000000000000284DOI Listing
December 2016

Progesterone: The neglected hormone in schizophrenia? A focus on progesterone-dopamine interactions.

Psychoneuroendocrinology 2016 12 24;74:126-140. Epub 2016 Aug 24.

Division of Biological Psychiatry and Mental Health, The Florey Institute of Neuroscience and Mental Health, University of Melbourne, VIC, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.psyneuen.2016.08.019DOI Listing
December 2016

Balancing Blood Sample Volume with 3Rs: Implementation and Best Practices for Small Molecule Toxicokinetic Assessments in Rats.

ILAR J 2016 12;57(2):157-165

Eric Harstad, PhD, DABT, and Jessica Couch, PhD, DABT, are senior scientists and therapeutic area leaders in the Department of Safety Assessment, Genentech, Inc. in South San Francisco, CA. Roxanne Andaya, BS, is a toxicology analyst in the Department of Safety Assessment, Genentech, Inc. Xiao Ding, PhD, Xiaorong Liang, PhD, and Bianca Liederer, PhD, are senior scientists in the Department of Drug Metabolism and Pharmacokinetics, Genentech, Inc. Kirsten Messick, BS, and Trung Nguyen, BS, are scientific managers in the Department of Safety Assessment, Genentech, Inc. Michelle Schweiger, BS, LATG, is a group leader in the Department of Safety Assessment, Genentech, Inc. Jacqueline Tarrant, BVSc, PhD, DACVP, is a senior scientist in the Department of Safety Assessment, Genentech, Inc. Shelly Zhong, BS, is a senior study monitor in the Department of Safety Assessment, Genentech, Inc. Brian Dean, PhD, is a Director of Bioanalytical Sciences in the Department of Drug Metabolism and Pharmacokinetics, Genentech, Inc.

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http://dx.doi.org/10.1093/ilar/ilw023DOI Listing
December 2016

Understanding the pathophysiology of schizophrenia: Contributions from the Melbourne Psychiatric Brain Bank.

Schizophr Res 2016 11 13;177(1-3):108-114. Epub 2016 May 13.

The Molecular Psychiatry Laboratory, The Florey Institute for Neuroscience and Mental Health, Parkville, Victoria, Australia.

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http://dx.doi.org/10.1016/j.schres.2016.04.037DOI Listing
November 2016

The distribution of muscarinic M1 receptors in the human hippocampus.

J Chem Neuroanat 2016 11 18;77:187-192. Epub 2016 Jul 18.

The Molecular Psychiatry Laboratory, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Victoria, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.jchemneu.2016.07.006DOI Listing
November 2016

The Role of Muscarinic Receptors in the Pathophysiology of Mood Disorders: A Potential Novel Treatment?

Curr Neuropharmacol 2015 ;13(6):739-49

Florey Institute for Neuroscience and Mental Health, 30 Royal Parade, Parkville, Victoria 3052, Australia.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4759313PMC
http://dx.doi.org/10.2174/1570159x13666150612230045DOI Listing
September 2016

COMT genotype is associated with differential expression of muscarinic M1 receptors in human cortex.

Am J Med Genet B Neuropsychiatr Genet 2016 09 8;171(6):784-9. Epub 2016 Mar 8.

The Florey Institute for Neuroscience and Mental Health, Parkville, Victoria, Australia.

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http://dx.doi.org/10.1002/ajmg.b.32440DOI Listing
September 2016

Recommendations on the Development of a Bioanalytical Assay for 4β-Hydroxycholesterol, an Emerging Endogenous Biomarker of CYP3A Activity.

AAPS J 2016 09 27;18(5):1056-1066. Epub 2016 Jun 27.

Drug Metabolism and Pharmacokinetics, Novartis, East Hanover, New Jersey, USA.

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http://dx.doi.org/10.1208/s12248-016-9949-3DOI Listing
September 2016

Increased cortical expression of the zinc transporter SLC39A12 suggests a breakdown in zinc cellular homeostasis as part of the pathophysiology of schizophrenia.

NPJ Schizophr 2016 9;2:16002. Epub 2016 Mar 9.

The Molecular Psychiatry Laboratory, The Florey Institute of Neuroscience and Mental Health, Parkville, VIC, Australia; Department of Psychaitry, University of Melbourne, Melbourne, VIC, Australia; CRC for Mental Health, Carlton South, VIC, Australia.

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http://dx.doi.org/10.1038/npjschz.2016.2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4898896PMC
June 2016

Changes in BQCA Allosteric Modulation of [(3)H]NMS Binding to Human Cortex within Schizophrenia and by Divalent Cations.

Neuropsychopharmacology 2016 May 29;41(6):1620-8. Epub 2015 Oct 29.

The Florey Institute for Neuroscience and Mental Health, Parkville, VIC, Australia.

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http://dx.doi.org/10.1038/npp.2015.330DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4832025PMC
May 2016

Validating reference genes using minimally transformed qpcr data: findings in human cortex and outcomes in schizophrenia.

BMC Psychiatry 2016 05 20;16:154. Epub 2016 May 20.

The Florey Institute for Neuroscience and Mental Health, Parkville, VIC, Australia.

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http://dx.doi.org/10.1186/s12888-016-0855-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4875643PMC
May 2016

Changes in Muscarinic M2 Receptor Levels in the Cortex of Subjects with Bipolar Disorder and Major Depressive Disorder and in Rats after Treatment with Mood Stabilisers and Antidepressants.

Int J Neuropsychopharmacol 2016 Apr 20;19(4). Epub 2016 Apr 20.

Molecular Psychiatry Laboratories, Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia (Drs Gibbons, Jeon, Scarr, and Dean); Department of Psychiatry, The University of Melbourne, Parkville, Victoria, Australia (Drs Gibbons, Jeon, Scarr, and Dean).

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http://dx.doi.org/10.1093/ijnp/pyv118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4851264PMC
April 2016

Fatty acid composition and fatty acid binding protein expression in the postmortem frontal cortex of patients with schizophrenia: A case-control study.

Schizophr Res 2016 Mar 17;171(1-3):225-32. Epub 2016 Jan 17.

Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Saitama 351-0198, Japan.

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http://dx.doi.org/10.1016/j.schres.2016.01.014DOI Listing
March 2016

Biomarkers in schizophrenia: A focus on blood based diagnostics and theranostics.

World J Psychiatry 2016 Mar 22;6(1):102-17. Epub 2016 Mar 22.

Chi-Yu Lai, Elizabeth Scarr, Madhara Udawela, Ian Everall, Brian Dean, the Florey Institute of Neuroscience and Mental Health, Parkville, VIC 3010, Australia.

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http://dx.doi.org/10.5498/wjp.v6.i1.102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4804259PMC
March 2016

Changes, adaptations, and applications of a bio inspired machine vision sensor - biomed 2013.

Biomed Sci Instrum 2013 ;49:20-4

University of Wyoming.

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February 2016

Generalized periodic discharges and 'triphasic waves': A blinded evaluation of inter-rater agreement and clinical significance.

Clin Neurophysiol 2016 Feb 7;127(2):1073-1080. Epub 2015 Aug 7.

Emory University School of Medicine, Department of Neurology, 1365 Clifton Rd, Atlanta, GA 30322, USA.

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http://dx.doi.org/10.1016/j.clinph.2015.07.018DOI Listing
February 2016

Surrogate analyte approach for quantitation of endogenous NAD(+) in human acidified blood samples using liquid chromatography coupled with electrospray ionization tandem mass spectrometry.

J Chromatogr B Analyt Technol Biomed Life Sci 2016 Feb 24;1011:69-76. Epub 2015 Dec 24.

Drug Metabolism and Pharmacokinetics, Genentech Inc., South San Francisco, CA 94080, United States. Electronic address:

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http://dx.doi.org/10.1016/j.jchromb.2015.12.040DOI Listing
February 2016

Lower [3H]LY341495 binding to mGlu2/3 receptors in the anterior cingulate of subjects with major depressive disorder but not bipolar disorder or schizophrenia.

J Affect Disord 2016 Jan 23;190:241-248. Epub 2015 Oct 23.

The Florey Institute for Neuroscience and Mental Health and the University of Melbourne, Victoria, Australia; Department of Psychiatry, University of Melbourne, Victoria, Australia.

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http://dx.doi.org/10.1016/j.jad.2015.10.004DOI Listing
January 2016

Changes in cholinergic and glutamatergic markers in the striatum from a sub-set of subjects with schizophrenia.

Schizophr Res 2015 Dec 3;169(1-3):83-88. Epub 2015 Nov 3.

The Department of Psychiatry, The University of Melbourne, Parkville, Australia; The Molecular Psychiatry Laboratories, The Florey Institute for Neuroscience and Mental Health, Parkville, Australia.

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http://dx.doi.org/10.1016/j.schres.2015.10.028DOI Listing
December 2015

The effect of a muscarinic receptor 1 gene variant on grey matter volume in schizophrenia.

Psychiatry Res 2015 Nov 10;234(2):182-7. Epub 2015 Sep 10.

Department of Psychiatry, The University of Melbourne, Parkville, Victoria 3052, Australia; Molecular Psychiatry Laboratory, Florey Institute of Neuroscience and Mental Health, Parkville, Victoria 3052, Australia.

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http://dx.doi.org/10.1016/j.pscychresns.2015.09.004DOI Listing
November 2015

A Role for Estrogen in Schizophrenia: Clinical and Preclinical Findings.

Int J Endocrinol 2015 27;2015:615356. Epub 2015 Sep 27.

Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, VIC 3010, Australia.

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http://dx.doi.org/10.1155/2015/615356DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4600562PMC
October 2015

Determination of GDC-0980 (apitolisib), a small molecule dual phosphatidylinositide 3-kinase/mammalian target of rapamycin inhibitor in dog plasma by LC-MS/MS to support a GLP toxicology study.

Biomed Chromatogr 2015 Aug 10;29(8):1274-9. Epub 2015 Feb 10.

Genentech, Drug Metabolism and Pharmacokinetics, MS 41-2A, 1 DNA Way, South San Francisco, CA, 94080, USA.

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http://dx.doi.org/10.1002/bmc.3417DOI Listing
August 2015

Fatty acid composition of the postmortem prefrontal cortex of patients with schizophrenia, bipolar disorder, and major depressive disorder.

Psychiatry Res 2015 Jun 23;227(2-3):353-9. Epub 2015 Jan 23.

Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Saitama 351-0198, Japan.

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http://dx.doi.org/10.1016/j.psychres.2015.01.004DOI Listing
June 2015

Biomarkers for Psychiatry: The Journey from Fantasy to Fact, a Report of the 2013 CINP Think Tank.

Int J Neuropsychopharmacol 2015 Apr 21;18(10):pyv042. Epub 2015 Apr 21.

Department of Psychiatry, University of Melbourne, Victoria, Australia (Drs Scarr and Dean); The Molecular Psychiatry Laboratory, Florey Institute for Neuroscience and Mental Health, Victoria, Australia (Drs Scarr and Dean); Pole d'Innovation Thérapeutique en Neuropsychiatrie, Institut de Recherches Servier, Paris, France (Dr Millan); Cambridge Centre for Neuropsychiatric Research, University of Cambridge, UK (Dr Bahn); Pharma Research & Early Development, NORD, DTA, Hoffman - La Roche, Ltd., Basel, Switzerland (Dr Bertolino); School of Medicine, Basic Medical Sciences, Neuroscience and Sense Organs (DMBNOS), University of Bari, Italy (Dr Bertolino); Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany (Dr Turck); Institute of Psychiatry, Kings College London, London, UK (Dr Kapur); Department of Psychiatry, Ludwig-Maximilians-University, Munich, Germany (Dr Möller).

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4648162PMC
April 2015

Discovery of dual leucine zipper kinase (DLK, MAP3K12) inhibitors with activity in neurodegeneration models.

J Med Chem 2015 Jan 23;58(1):401-18. Epub 2014 Oct 23.

Departments of †Discovery Chemistry, ‡Neurosciences, §Drug Metabolism and Pharmacokinetics, and ∥Biochemical and Cellular Pharmacology, Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States.

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http://dx.doi.org/10.1021/jm5013984DOI Listing
January 2015

Determination of cobimetinib in human plasma using protein precipitation extraction and high-performance liquid chromatography coupled to mass spectrometry.

J Chromatogr B Analyt Technol Biomed Life Sci 2014 Dec 7;972:117-23. Epub 2014 Oct 7.

Drug Metabolism and Pharmacokinetics, Genentech, South San Francisco, CA 94080, United States.

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December 2014

The use of betaine HCl to enhance dasatinib absorption in healthy volunteers with rabeprazole-induced hypochlorhydria.

AAPS J 2014 Nov 2;16(6):1358-65. Epub 2014 Oct 2.

Department of Bioengineering and Therapeutic Sciences, University of California, 533 Parnassus Avenue, Room U-68, San Francisco, California, 94143-0912, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4389759PMC
November 2014

An investigation of the factors that regulate muscarinic receptor expression in schizophrenia.

Schizophr Res 2014 Sep 16;158(1-3):247-54. Epub 2014 Jul 16.

The Molecular Psychiatry Laboratory, The Florey Institute of Neuroscience and Mental Health, Parkville, Victoria 3010, Australia; Department of Psychiatry, The University of Melbourne Parkville, Victoria 3010, Australia.

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http://dx.doi.org/10.1016/j.schres.2014.06.039DOI Listing
September 2014

Potential molecular and cellular mechanism of psychotropic drugs.

Clin Psychopharmacol Neurosci 2014 Aug 12;12(2):94-110. Epub 2014 Aug 12.

Molecular Psychiatry Laboratory, The Florey Institute of Neuroscience and Mental Health, Victoria, Australia. ; Department of Psychiatry, The University of Melbourne, Parkville, Victoria, Australia.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4153869PMC
August 2014

Problems and solutions to filling the drying drug pipeline for psychiatric disorders: a report from the inaugural 2012 CINP Think Tank.

Int J Neuropsychopharmacol 2014 Jan 24;17(1):137-48. Epub 2013 Sep 24.

The Molecular Psychiatry Laboratory, The Florey Institute for Neuroscience and Mental Health, The University of Melbourne, Victoria 3010, Australia.

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January 2014

The use of a modified [3H]4-DAMP radioligand binding assay with increased selectivity for muscarinic M3 receptor shows that cortical CHRM3 levels are not altered in mood disorders.

Prog Neuropsychopharmacol Biol Psychiatry 2013 Dec 17;47:7-12. Epub 2013 Aug 17.

Molecular Psychiatry Laboratory, The Florey Institute of Neuroscience and Mental Health, Parkville, VIC, Australia; Department of Psychiatry, the University of Melbourne, Parkville, VIC, Australia.

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December 2013

Mapping the pathophysiology of schizophrenia: interactions between multiple cellular pathways.

Front Cell Neurosci 2013 28;7:238. Epub 2013 Nov 28.

Molecular Psychiatry Laboratory, Florey Institute of Neuroscience and Mental Health Parkville, VIC, Australia ; Department of Psychiatry, The University of Melbourne Parkville, VIC, Australia.

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http://dx.doi.org/10.3389/fncel.2013.00238DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3842583PMC
December 2013

Pharmacokinetics and absorption of the anticancer agents dasatinib and GDC-0941 under various gastric conditions in dogs--reversing the effect of elevated gastric pH with betaine HCl.

Mol Pharm 2013 Nov 11;10(11):4024-31. Epub 2013 Sep 11.

Department of Drug Metabolism and Pharmacokinetics, ‡Department of Small Molecule Pharmaceutical Sciences, and §Department of Small Molecule Clinical Pharmacology, Genentech, Inc. , South San Francisco, California 94080, United States.

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November 2013

Prevalence of acid-reducing agents (ARA) in cancer populations and ARA drug-drug interaction potential for molecular targeted agents in clinical development.

Mol Pharm 2013 Nov 24;10(11):4055-62. Epub 2013 Oct 24.

Clinical Pharmacology, Genentech Research and Early Development , 1 DNA Way, South San Francisco, California 94080, United States.

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November 2013

Cholinergic muscarinic receptors: new opportunities to treat psychiatric disorders.

Authors:
Brian Dean

Future Med Chem 2013 Sep;5(13):1547-9

Florey Institute for Neuroscience & Mental Health, Kenneth Myer Building, Genetics Lane, University of Melbourne, Victoria 3010, Australia.

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http://dx.doi.org/10.4155/fmc.13.134DOI Listing
September 2013

Biomarker investigations related to pathophysiological pathways in schizophrenia and psychosis.

Front Cell Neurosci 2013 26;7:95. Epub 2013 Jun 26.

Department of Psychiatry, Melbourne Brain Centre, The University of Melbourne Parkville, VIC, Australia.

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http://dx.doi.org/10.3389/fncel.2013.00095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3693064PMC
August 2013

Morphology-based wavelet features and multiple mother wavelet strategy for spike classification in EEG signals.

Conf Proc IEEE Eng Med Biol Soc 2012 ;2012:3959-62

Department of Electrical and Computer Engineering, Clemson University, Clemson, SC 29631, USA.

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http://dx.doi.org/10.1109/EMBC.2012.6346833DOI Listing
July 2013

Cholinergic muscarinic M4 receptor gene polymorphisms: a potential risk factor and pharmacogenomic marker for schizophrenia.

Schizophr Res 2013 May 11;146(1-3):279-84. Epub 2013 Mar 11.

Department of Psychiatry, Melbourne Brain Centre, Kenneth Myer Building, The University of Melbourne, VIC 3010, Australia.

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May 2013

Cholinergic connectivity: it's implications for psychiatric disorders.

Front Cell Neurosci 2013 3;7:55. Epub 2013 May 3.

Department of Psychiatry, The University of Melbourne Parkville, VIC, Australia ; Molecular Psychiatry Laboratories, Florey Institute of Neuroscience and Mental Health Parkville, VIC, Australia.

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http://dx.doi.org/10.3389/fncel.2013.00055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3642390PMC
May 2013

Epigenetic mechanisms and the serotonin 2A receptor in schizophrenia.

Authors:
Brian Dean

Schizophr Res 2013 Apr 8;145(1-3):128-9. Epub 2013 Feb 8.

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April 2013

A computational approach to understand phenotypic structure and constitutive mechanics relationships of single cells.

Ann Biomed Eng 2013 Mar 22;41(3):630-44. Epub 2012 Nov 22.

Department of Bioengineering, Clemson University, 301 Rhodes Research Center, Clemson, SC 29634, USA.

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http://dx.doi.org/10.1007/s10439-012-0690-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3594057PMC
March 2013

High-throughput liquid chromatography/mass spectrometry method for the quantitation of small molecules using accurate mass technologies in supporting discovery drug screening.

Rapid Commun Mass Spectrom 2013 Feb;27(3):401-8

Genentech, Inc., Drug Metabolism and Pharmacokinetics, MS 412A, 1 DNA Way, South San Francisco, CA 94080, USA.

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http://dx.doi.org/10.1002/rcm.6461DOI Listing
February 2013

Altered neuronal markers following treatment with mood stabilizer and antipsychotic drugs indicate an increased likelihood of neurotransmitter release.

Clin Psychopharmacol Neurosci 2012 Apr 30;10(1):25-33. Epub 2012 Apr 30.

Department of Psychiatry, Rebecca L. Cooper Research Laboratories, The Mental Health Research Institute, Melbourne Brain Centre, The University of Melbourne, Parkville, Australia.

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http://dx.doi.org/10.9758/cpn.2012.10.1.25DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3569157PMC
April 2012