Brian D Ross

Brian D Ross

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Brian D Ross

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Ocular Toxicity Profile of ST-162 and ST-168 as Novel Bifunctional MEK/PI3K Inhibitors.

J Ocul Pharmacol Ther 2018 Jul/Aug;34(6):477-485. Epub 2018 Apr 30.

1 Department of Ophthalmology and Visual Sciences, University of Michigan , Medical School, Ann Arbor, Michigan.

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http://dx.doi.org/10.1089/jop.2017.0126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6088257PMC
November 2019

Positron Emission Tomography/Magnetic Resonance Imaging of Glioblastoma Using a Functionalized Gadofullerene Nanoparticle.

ACS Appl Mater Interfaces 2019 Jun 10;11(24):21343-21352. Epub 2019 Jun 10.

Department of Radiology, Center for Molecular Imaging , University of Michigan , Ann Arbor , Michigan 48109-2200 , United States.

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http://dx.doi.org/10.1021/acsami.9b03542DOI Listing
June 2019

Voxel-Wise Longitudinal Parametric Response Mapping Analysis of Chest Computed Tomography in Smokers.

Acad Radiol 2019 02 26;26(2):217-223. Epub 2018 Jul 26.

Division of Pulmonary and Critical Care Medicine, University of Michigan, 3916 Taubman Center, 1500 E Medical Center Drive, Ann Arbor, MI. Electronic address:

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http://dx.doi.org/10.1016/j.acra.2018.05.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340741PMC
February 2019

Vascular Deformation Mapping (VDM) of thoracic aortic aneurysm: an application for color 3D printing in aortic disease.

Ann Transl Med 2018 Dec;6(Suppl 2):S123

Department of Radiology, University of Michigan, Ann Arbor, MI, USA.

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http://dx.doi.org/10.21037/atm.2018.12.16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330632PMC
December 2018

Primary myelofibrosis evolving to an aplastic appearing marrow.

Clin Case Rep 2018 Jul 31;6(7):1393-1395. Epub 2018 May 31.

Division of Hematology/Oncology Department of Internal Medicine University of Michigan Ann Arbor MI USA.

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http://dx.doi.org/10.1002/ccr3.1618DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6028358PMC
July 2018

Multimodal imaging provides insight into targeted therapy response in metastatic prostate cancer to the bone.

Am J Nucl Med Mol Imaging 2018 5;8(3):189-199. Epub 2018 Jun 5.

Department of Radiology, University of Michigan Ann Arbor, Michigan, United States of America.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6056245PMC
June 2018

A Bifunctional MAPK/PI3K Antagonist for Inhibition of Tumor Growth and Metastasis.

Mol Cancer Ther 2017 11 3;16(11):2340-2350. Epub 2017 Aug 3.

Center for Molecular Imaging, The University of Michigan Medical School, Ann Arbor, Michigan.

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http://dx.doi.org/10.1158/1535-7163.MCT-17-0207DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5669819PMC
November 2017

Structure-Guided Design and Initial Studies of a Bifunctional MEK/PI3K Inhibitor (ST-168).

ACS Med Chem Lett 2017 Aug 24;8(8):808-813. Epub 2017 Jul 24.

Center for Molecular Imaging, Department of Radiology, Departments of Chemical and Biomedical Engineering, and Department of Ophthalmology and Visual Sciences, The University of Michigan Medical School, Ann Arbor, Michigan 48109, United States.

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http://dx.doi.org/10.1021/acsmedchemlett.7b00111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5554897PMC
August 2017

In Vivo Targeting and Positron Emission Tomography Imaging of Tumor with Intrinsically Radioactive Metal-Organic Frameworks Nanomaterials.

ACS Nano 2017 04 28;11(4):4315-4327. Epub 2017 Mar 28.

Department of Radiology, Center for Molecular Imaging, University of Michigan , Ann Arbor, Michigan 48109-2200, United States.

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http://dx.doi.org/10.1021/acsnano.7b01530DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5477053PMC
April 2017

Semiautomated Workflow for Clinically Streamlined Glioma Parametric Response Mapping.

Tomography 2016 Dec;2(4):267-275

Department of Radiology, Center for Molecular Imaging, University of Michigan, Ann Arbor, Michigan.

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http://dx.doi.org/10.18383/j.tom.2016.00181DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5345939PMC
December 2016

Antibody-based PET of uPA/uPAR signaling with broad applicability for cancer imaging.

Oncotarget 2016 Nov;7(45):73912-73924

Center for Molecular Imaging, Department of Radiology, University of Michigan, Ann Arbor, Michigan 48109, United States.

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http://dx.doi.org/10.18632/oncotarget.12528DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5342023PMC
November 2016

In vivo targeting of metastatic breast cancer via tumor vasculature-specific nano-graphene oxide.

Biomaterials 2016 10 26;104:361-71. Epub 2016 Jul 26.

Center for Molecular Imaging, Department of Radiology, University of Michigan - Ann Arbor, MI 48109-2200, United States; University of Michigan Comprehensive Cancer Center, MI 48109-0944, United States. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01429612163036
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http://dx.doi.org/10.1016/j.biomaterials.2016.07.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5644339PMC
October 2016

Discovery of Bifunctional Oncogenic Target Inhibitors against Allosteric Mitogen-Activated Protein Kinase (MEK1) and Phosphatidylinositol 3-Kinase (PI3K).

J Med Chem 2016 Mar 15;59(6):2512-22. Epub 2016 Mar 15.

Center for Molecular Imaging, ‡Department of Radiology, and §Department of Biological Chemistry, The University of Michigan Medical School , Ann Arbor, Michigan 48109, United States.

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http://pubs.acs.org/doi/10.1021/acs.jmedchem.5b01655
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http://dx.doi.org/10.1021/acs.jmedchem.5b01655DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4841451PMC
March 2016

A Pilot Study of Quantitative MRI Parametric Response Mapping of Bone Marrow Fat for Treatment Assessment in Myelofibrosis.

Tomography 2016 Mar;2(1):67-78

Center for Molecular Imaging, Department of Radiology, University of Michigan, Ann Arbor, MI, USA; Department of Biological Chemistry, University of Michigan, Ann Arbor, MI, USA.

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http://dx.doi.org/10.18383/j.tom.2016.00115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872873PMC
March 2016

Demonstration of an Inline Publication Image Viewer: The Future of Radiological Publishing.

Authors:
Brian D Ross

Tomography 2016 Mar;2(1):1-2

Editor, Tomography , Roger A. Berg Research Professor of Radiology, University of Michigan School of Medicine, Ann Arbor, MI 48109-2200 USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5040350PMC
http://dx.doi.org/10.18383/j.tom.2016.00124DOI Listing
March 2016

If "A Picture is Worth a Thousand Words," What is a Video Worth?

Authors:
Brian D Ross

Tomography 2015 Dec;1(2):79-80

University of Michigan School of Medicine, Departments of Radiology & Biological Chemistry, Ann Arbor, MI 48109-2200,

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http://dx.doi.org/10.18383/j.tom.2015.00178DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4714323PMC
December 2015

Effects of ageing and smoking on pulmonary computed tomography scans using parametric response mapping.

Eur Respir J 2015 Oct 25;46(4):1193-6. Epub 2015 Jun 25.

Department of Pulmonary Diseases, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD, Groningen, The Netherlands Both authors contributed equally

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http://erj.ersjournals.com/content/46/4/1193.full.pdf
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http://erj.ersjournals.com/lookup/doi/10.1183/09031936.00009
Publisher Site
http://dx.doi.org/10.1183/09031936.00009415DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4591191PMC
October 2015

Dual inhibition of allosteric mitogen-activated protein kinase (MEK) and phosphatidylinositol 3-kinase (PI3K) oncogenic targets with a bifunctional inhibitor.

Bioorg Med Chem 2015 Apr 6;23(7):1386-94. Epub 2015 Mar 6.

Center for Molecular Imaging, The University of Michigan Medical School, 109 Zina Pitcher Place, Ann Arbor, MI 48109, USA; Department of Radiology, The University of Michigan Medical School, Ann Arbor, MI 48109, USA; Department of Biological Chemistry, The University of Michigan Medical School, Ann Arbor, MI 48109, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2015.02.053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4370322PMC
April 2015

Changes in the neurochemistry of athletes with repetitive brain trauma: preliminary results using localized correlated spectroscopy.

Alzheimers Res Ther 2015 15;7(1):13. Epub 2015 Mar 15.

Center for Clinical Spectroscopy, Department of Radiology, Brigham & Women's Hospital, Harvard Medical School, 4 Blackfan Street HIM-820, Boston, MA 02115 USA ; Centre for MR in Health, School of Health Sciences, University of Newcastle, Newcastle, NSW 2308 Australia.

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http://dx.doi.org/10.1186/s13195-015-0094-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4361214PMC
March 2015

Parametric response mapping as an indicator of bronchiolitis obliterans syndrome after hematopoietic stem cell transplantation.

Biol Blood Marrow Transplant 2014 Oct 18;20(10):1592-8. Epub 2014 Jun 18.

Blood and Marrow Transplant Program, University of Michigan, Ann Arbor, Michigan; Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, Michigan; Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan.

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http://dx.doi.org/10.1016/j.bbmt.2014.06.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4163140PMC
October 2014

Analysis and correction of gradient nonlinearity bias in apparent diffusion coefficient measurements.

Magn Reson Med 2014 Mar;71(3):1312-23

Department of Radiology, University of Michigan, Ann Arbor, Michigan, USA.

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http://dx.doi.org/10.1002/mrm.24773DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3823647PMC
March 2014

Impact of fasting on human brain acid-base homeostasis using natural abundance (13) C and (31) P MRS.

J Magn Reson Imaging 2014 Feb 3;39(2):398-401. Epub 2013 Jun 3.

Huntington Medical Research Institutes, Pasadena, California, USA.

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http://dx.doi.org/10.1002/jmri.24166DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3766421PMC
February 2014

Reversal of metabolic deficits by lipoic acid in a triple transgenic mouse model of Alzheimer's disease: a 13C NMR study.

J Cereb Blood Flow Metab 2014 Feb 13;34(2):288-96. Epub 2013 Nov 13.

Pharmacology & Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, California, USA.

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http://dx.doi.org/10.1038/jcbfm.2013.196DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3915206PMC
February 2014

Mathematical modeling of PDGF-driven glioblastoma reveals optimized radiation dosing schedules.

Cell 2014 Jan;156(3):603-616

Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.

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http://dx.doi.org/10.1016/j.cell.2013.12.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3923371PMC
January 2014

Electrographic seizures are significantly reduced by in vivo inhibition of neuronal uptake of extracellular glutamine in rat hippocampus.

Epilepsy Res 2013 Nov 1;107(1-2):20-36. Epub 2013 Sep 1.

Huntington Medical Research Institutes, 660 South Fair Oaks Avenue, Pasadena, CA 91105, USA. Electronic address:

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http://dx.doi.org/10.1016/j.eplepsyres.2013.08.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4232934PMC
November 2013

Molecular imaging of the ATM kinase activity.

Int J Radiat Oncol Biol Phys 2013 Aug 29;86(5):969-77. Epub 2013 May 29.

Department of Radiation Oncology, Ohio State University, Columbus, Ohio, USA.

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http://dx.doi.org/10.1016/j.ijrobp.2013.04.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3710537PMC
August 2013

High-field MRS in clinical drug development.

Authors:
Brian D Ross

Expert Opin Drug Discov 2013 Jul 10;8(7):849-63. Epub 2013 May 10.

Huntington Medical Research Institutes, Magnetic Resonance Spectroscopy Unit, 10 Pico Street, Pasadena 91105, USA.

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http://dx.doi.org/10.1517/17460441.2013.795144DOI Listing
July 2013

Molecular imaging reveals a role for AKT in resistance to cisplatin for ovarian endometrioid adenocarcinoma.

Clin Cancer Res 2013 Jan 24;19(1):158-69. Epub 2012 Oct 24.

Center for Molecular Imaging, Departments of Radiation Oncology, The University of Michigan Medical School, Ann Arbor, MI 48109, USA.

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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-12-2380DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3537896PMC
January 2013

Hyperpolarized water as an MR imaging contrast agent: feasibility of in vivo imaging in a rat model.

Radiology 2012 Nov 20;265(2):418-25. Epub 2012 Sep 20.

Department of Chemistry, University of California, Santa Barbara, Mesa Road, Santa Barbara, CA 93106, USA.

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http://dx.doi.org/10.1148/radiol.12111804DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3480810PMC
November 2012

Guidelines for acquiring and reporting clinical neurospectroscopy.

Semin Neurol 2012 Sep 29;32(4):432-53. Epub 2013 Jan 29.

Department of Radiology, Brigham and Women's Hospital, Boston, MA 02115, USA.

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https://www.thieme-connect.com/products/ejournals/pdf/10.105
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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0032-1331814
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http://dx.doi.org/10.1055/s-0032-1331814DOI Listing
September 2012

Real-time molecular imaging of tricarboxylic acid cycle metabolism in vivo by hyperpolarized 1-(13)C diethyl succinate.

J Am Chem Soc 2012 Jan 22;134(2):934-43. Epub 2011 Dec 22.

Enhanced MR Laboratory, Huntington Medical Research Institutes, Pasadena, California, USA.

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http://dx.doi.org/10.1021/ja2040865DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3262122PMC
January 2012

Synthesis and investigation of a radioiodinated F3 peptide analog as a SPECT tumor imaging radioligand.

PLoS One 2011 19;6(7):e22418. Epub 2011 Jul 19.

Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0022418PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3139646PMC
December 2011

Parahydrogen-induced polarization (PHIP) hyperpolarized MR receptor imaging in vivo: a pilot study of 13C imaging of atheroma in mice.

NMR Biomed 2011 Oct 28;24(8):1023-8. Epub 2011 Apr 28.

Enhanced Magnetic Resonance Laboratory, Huntington Medical Research Institutes, Pasadena, CA 91105, USA.

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http://dx.doi.org/10.1002/nbm.1717DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3240663PMC
October 2011

Molecular imaging of epidermal growth factor receptor kinase activity.

Anal Biochem 2011 Oct 30;417(1):57-64. Epub 2011 May 30.

Department of Radiation Oncology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S000326971100363
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http://dx.doi.org/10.1016/j.ab.2011.05.040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3204941PMC
October 2011

Applications of molecular imaging.

Prog Mol Biol Transl Sci 2010 ;95:237-98

Department of Radiology, University of Michigan, Center for Molecular Imaging, Ann Arbor, Michigan, USA.

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http://dx.doi.org/10.1016/B978-0-12-385071-3.00009-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4327770PMC
July 2011

Molecular imaging of akt enables early prediction of response to molecular targeted therapy.

Transl Oncol 2011 Jun 1;4(3):122-5. Epub 2011 Jun 1.

Department of Radiation Oncology, University of Michigan Cancer Center, University of Michigan, Ann Arbor, MI, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3104693PMC
http://dx.doi.org/10.1593/tlo.11112DOI Listing
June 2011

Molecular imaging of c-Met tyrosine kinase activity.

Anal Biochem 2011 May 27;412(1):1-8. Epub 2011 Jan 27.

Department of Radiation Oncology, University of Michigan, Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.1016/j.ab.2011.01.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3265038PMC
May 2011

Convection enhanced delivery of carboplatin in combination with radiotherapy for the treatment of brain tumors.

J Neurooncol 2011 Feb 25;101(3):379-90. Epub 2010 Jun 25.

Department of Pathology, The Ohio State University, 165 Hamilton Hall, 1645 Neil Avenue, Columbus, OH 43210, USA.

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http://dx.doi.org/10.1007/s11060-010-0272-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4492111PMC
February 2011

Chronic electrographic seizure reduces glutamine and elevates glutamate in the extracellular fluid of rat brain.

Brain Res 2011 Jan 25;1371:180-91. Epub 2010 Nov 25.

Huntington Medical Research Institutes, 660 S. Fair Oaks Ave., Pasadena, CA 91105, USA.

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http://dx.doi.org/10.1016/j.brainres.2010.11.064DOI Listing
January 2011

Targeted imaging and therapy of brain cancer using theranostic nanoparticles.

Mol Pharm 2010 Dec 27;7(6):1921-9. Epub 2010 Oct 27.

Center for Molecular Imaging, Departments of Radiation Oncology and, and Radiology, University of Michigan, Ann Arbor, Michigan 48109, United States.

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http://pubs.acs.org/doi/abs/10.1021/mp100298r
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http://dx.doi.org/10.1021/mp100298rDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3291122PMC
December 2010

Assessment of multiexponential diffusion features as MRI cancer therapy response metrics.

Magn Reson Med 2010 Nov 21;64(5):1499-509. Epub 2010 Sep 21.

Department of Radiology, Center for Molecular Imaging, University of Michigan, Ann Arbor, Michigan 48109-2200, USA.

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http://dx.doi.org/10.1002/mrm.22507DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2965786PMC
November 2010

Molecular imaging of glycogen synthase kinase-3beta and casein kinase-1alpha kinases.

Anal Biochem 2010 Oct 16;405(2):246-54. Epub 2010 Jun 16.

Department of Radiation Oncology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.1016/j.ab.2010.06.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2922438PMC
October 2010

High-throughput molecular imaging for the identification of FADD kinase inhibitors.

J Biomol Screen 2010 Oct 20;15(9):1063-70. Epub 2010 Sep 20.

Department of Radiation Oncology, University of Michigan, Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.1177/1087057110380570DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3108567PMC
October 2010

Diffusion-weighted MRI for assessment of early cancer treatment response.

Curr Pharm Biotechnol 2010 Sep;11(6):701-8

Department of Radiation Oncology, University of Michigan, Ann Arbor, MI 48109, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4003912PMC
http://dx.doi.org/10.2174/138920110792246627DOI Listing
September 2010

Predicting and monitoring cancer treatment response with diffusion-weighted MRI.

J Magn Reson Imaging 2010 Jul;32(1):2-16

Department of Radiology, University Hospital of Bern, Inselspital, Bern, Switzerland.

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http://dx.doi.org/10.1002/jmri.22167DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2918419PMC
July 2010

Novel molecular imaging platform for monitoring oncological kinases.

Cancer Cell Int 2010 Jul 8;10:23. Epub 2010 Jul 8.

Department of Radiation Oncology, University of Michigan, Ann Arbor MI 48109 USA.

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http://dx.doi.org/10.1186/1475-2867-10-23DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2914645PMC
July 2010

Molecular imaging of N-linked glycosylation suggests glycan biosynthesis is a novel target for cancer therapy.

Clin Cancer Res 2010 Jun 22;16(12):3205-14. Epub 2010 Apr 22.

Department of Radiation Oncology, The University of Michigan, Ann Arbor, Michigan, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-09-3331DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3413408PMC
June 2010

Metabolic Abnormalities in Abstinent Methamphetamine Dependent Subjects.

Subst Abuse 2010 Apr;2010(4):9-20

Huntington Medical Research Institutes, Pasadena, CA, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2872246PMC
http://dx.doi.org/10.4137/sart.s4625DOI Listing
April 2010