Brian D Lichty

Brian D Lichty

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Brian D Lichty

Brian D Lichty

Publications by authors named "Brian D Lichty"

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Detection of Tumor Antigen-Specific T-Cell Responses After Oncolytic Vaccination.

Methods Mol Biol 2020 ;2058:191-211

Department of Pathology and Molecular Medicine, McMaster Immunology Research Centre, McMaster University, Hamilton, ON, Canada.

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http://dx.doi.org/10.1007/978-1-4939-9794-7_12DOI Listing
January 2020

Excipient selection for thermally stable enveloped and non-enveloped viral vaccine platforms in dry powders.

Int J Pharm 2019 Apr 28;561:66-73. Epub 2019 Feb 28.

Department of Chemical Engineering, McMaster University, Hamilton, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ijpharm.2019.02.035DOI Listing
April 2019

Preclinical development of peptide vaccination combined with oncolytic MG1-E6E7 for HPV-associated cancer.

Vaccine 2018 04 12;36(16):2181-2192. Epub 2018 Mar 12.

McMaster Immunology Research Centre, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Canada; Turnstone Biologics, Ottawa, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0264410X183025
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http://dx.doi.org/10.1016/j.vaccine.2018.02.070DOI Listing
April 2018

Maraba virus-vectored cancer vaccines represent a safe and novel therapeutic option for cats.

Sci Rep 2017 Nov 16;7(1):15738. Epub 2017 Nov 16.

Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, Ontario, N1G 2W1, Canada.

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http://dx.doi.org/10.1038/s41598-017-15992-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5691073PMC
November 2017

Customized Viral Immunotherapy for HPV-Associated Cancer.

Cancer Immunol Res 2017 10 14;5(10):847-859. Epub 2017 Sep 14.

McMaster Immunology Research Centre, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Canada.

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http://dx.doi.org/10.1158/2326-6066.CIR-17-0102DOI Listing
October 2017

Oncolytic Viruses: Therapeutics With an Identity Crisis.

EBioMedicine 2016 Jul 2;9:31-36. Epub 2016 Jul 2.

Turnstone Biologics, 787 Bank Street, Ottawa, Ontario K1S 3V5, Canada; Centre for Innovative Cancer Therapeutics, Ottawa Hospital Research Institute, 501 Smyth Rd, Ottawa, ON K1H 8L6, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2016.06.046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4972563PMC
July 2016

Privileged Antigen Presentation in Splenic B Cell Follicles Maximizes T Cell Responses in Prime-Boost Vaccination.

J Immunol 2016 06 27;196(11):4587-95. Epub 2016 Apr 27.

Department of Pathology and Molecular Medicine, McMaster Immunology Research Centre, McMaster University, Hamilton, Ontario L8N 3Z5, Canada

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http://dx.doi.org/10.4049/jimmunol.1600106DOI Listing
June 2016

Cancer immunology and canine malignant melanoma: A comparative review.

Vet Immunol Immunopathol 2016 Jan 1;169:15-26. Epub 2015 Dec 1.

McMaster Immunology Research Centre, Department of Pathology and Molecular Medicine, McMaster University, 1280 Main Street West, Hamilton, Ontario L8S 4K1, Canada.

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http://dx.doi.org/10.1016/j.vetimm.2015.11.003DOI Listing
January 2016

Microvesicles: ubiquitous contributors to infection and immunity.

J Leukoc Biol 2015 Feb 3;97(2):237-45. Epub 2014 Dec 3.

McMaster Immunology Research Centre, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada

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http://doi.wiley.com/10.1189/jlb.3RU0513-292RR
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http://dx.doi.org/10.1189/jlb.3RU0513-292RRDOI Listing
February 2015

Going viral with cancer immunotherapy.

Nat Rev Cancer 2014 Aug 3;14(8):559-67. Epub 2014 Jul 3.

Centre for Innovative Cancer Therapeutics, Ottawa Hospital Research Institute, Ottawa, Ontario K1H 8L6, Canada; and the Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada.

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http://dx.doi.org/10.1038/nrc3770DOI Listing
August 2014

Maraba virus as a potent oncolytic vaccine vector.

Mol Ther 2014 Feb 25;22(2):420-429. Epub 2013 Oct 25.

McMaster Immunology Research Center, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1038/mt.2013.249DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3916044PMC
February 2014

Human coronavirus OC43 nucleocapsid protein binds microRNA 9 and potentiates NF-κB activation.

J Virol 2014 Jan 9;88(1):54-65. Epub 2013 Oct 9.

McMaster Immunology Research Centre, Department of Pathology & Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1128/JVI.02678-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3911702PMC
January 2014

Immunogenic HSV-mediated oncolysis shapes the antitumor immune response and contributes to therapeutic efficacy.

Mol Ther 2014 Jan 9;22(1):123-31. Epub 2013 Oct 9.

Department of Pathology and Molecular Medicine, McMaster Immunology Research Centre, Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1038/mt.2013.238DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3978812PMC
January 2014

Evolution of oncolytic viruses: novel strategies for cancer treatment.

Immunotherapy 2013 Nov;5(11):1191-206

McMaster Immunology Research Centre, McMaster University, 1280 Main Street W, Hamilton, ON, Canada, L8S 4K1.

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http://dx.doi.org/10.2217/imt.13.123DOI Listing
November 2013

Combining oncolytic HSV-1 with immunogenic cell death-inducing drug mitoxantrone breaks cancer immune tolerance and improves therapeutic efficacy.

Cancer Immunol Res 2013 Nov 19;1(5):309-19. Epub 2013 Aug 19.

Authors' Affiliation: Department of Pathology and Molecular Medicine, McMaster Immunology Research Centre, Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1158/2326-6066.CIR-13-0059-TDOI Listing
November 2013

Panorama from the oncolytic virotherapy summit.

Mol Ther 2013 Oct;21(10):1814-8

McMaster Immunology Research Center, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1038/mt.2013.207DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3808141PMC
October 2013

Delivery of viral-vectored vaccines by B cells represents a novel strategy to accelerate CD8(+) T-cell recall responses.

Blood 2013 Mar 16;121(13):2432-9. Epub 2013 Jan 16.

Department of Pathology and Molecular Medicine, McMaster Immunology Research Centre, McMaster University, Hamilton, ON, Canada.

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http://dx.doi.org/10.1182/blood-2012-06-438481DOI Listing
March 2013

IL-15 can signal via IL-15Rα, JNK, and NF-κB to drive RANTES production by myeloid cells.

J Immunol 2012 May 23;188(9):4149-57. Epub 2012 Mar 23.

Department of Pathology and Molecular Medicine, McMaster Immunology Research Centre and Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario L8S 4K1, Canada.

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http://dx.doi.org/10.4049/jimmunol.1101883DOI Listing
May 2012

Vesicular stomatitis virus oncolytic treatment interferes with tumor-associated dendritic cell functions and abrogates tumor antigen presentation.

J Virol 2011 Dec 14;85(23):12160-9. Epub 2011 Sep 14.

Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1128/JVI.05703-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3209377PMC
December 2011

Strategies to enhance viral penetration of solid tumors.

Hum Gene Ther 2011 Sep 19;22(9):1053-60. Epub 2011 May 19.

Centre for Gene Therapeutics, McMaster University, Hamilton, ON, Canada L8N 3Z5.

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http://dx.doi.org/10.1089/hum.2010.227DOI Listing
September 2011

IL-15 and type I interferon are required for activation of tumoricidal NK cells by virus-infected dendritic cells.

Cancer Res 2011 Apr 9;71(7):2497-506. Epub 2011 Feb 9.

Department of Pathology and Molecular Medicine and Medical Sciences Program, McMaster University, Hamilton, Ontario, Canada.

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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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http://dx.doi.org/10.1158/0008-5472.CAN-10-3025DOI Listing
April 2011

Adaptive antiviral immunity is a determinant of the therapeutic success of oncolytic virotherapy.

Mol Ther 2011 Feb 30;19(2):335-44. Epub 2010 Nov 30.

Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1038/mt.2010.264DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3034857PMC
February 2011

Combining oncolytic virotherapy and tumour vaccination.

Cytokine Growth Factor Rev 2010 Apr-Jun;21(2-3):143-8. Epub 2010 Mar 11.

Centre for Gene Therapeutics, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada L8N 3Z5.

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http://dx.doi.org/10.1016/j.cytogfr.2010.02.009DOI Listing
September 2010

Potentiating cancer immunotherapy using an oncolytic virus.

Mol Ther 2010 Aug 15;18(8):1430-9. Epub 2010 Jun 15.

Centre for Gene Therapeutics, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1038/mt.2010.98DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2927075PMC
August 2010

FimH can directly activate human and murine natural killer cells via TLR4.

Mol Ther 2010 Jul 4;18(7):1379-88. Epub 2010 May 4.

Centre for Gene Therapeutics, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1038/mt.2010.75DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2911256PMC
July 2010

Immunotherapy can reject intracranial tumor cells without damaging the brain despite sharing the target antigen.

J Immunol 2010 Apr 17;184(8):4269-75. Epub 2010 Mar 17.

Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.4049/jimmunol.0901447DOI Listing
April 2010

Intelligent design: combination therapy with oncolytic viruses.

Mol Ther 2010 Feb 22;18(2):251-63. Epub 2009 Dec 22.

Division of Experimental Therapeutics, Toronto General Research Institute, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/mt.2009.283DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2839289PMC
February 2010

Vesicular stomatitis virus as a novel cancer vaccine vector to prime antitumor immunity amenable to rapid boosting with adenovirus.

Mol Ther 2009 Oct 14;17(10):1814-21. Epub 2009 Jul 14.

Centre for Gene Therapeutics, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario L8N 3Z5, Canada.

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http://dx.doi.org/10.1038/mt.2009.154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2835010PMC
October 2009

Diplomatic immunity: turning a foe into an ally.

Curr Opin Mol Ther 2009 Feb;11(1):13-21

Ottawa Health Research Institute, Centre for Cancer Therapeutics, 503 Smyth Road, Ottawa, Ontario, K1H 8L6, Canada.

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February 2009

The p14 FAST protein of reptilian reovirus increases vesicular stomatitis virus neuropathogenesis.

J Virol 2009 Jan 29;83(2):552-61. Epub 2008 Oct 29.

Department of Microbiology and Immunology, Ottawa Health Research Institute, University of Ottawa, Ontario, Canada.

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http://dx.doi.org/10.1128/JVI.01921-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2612406PMC
January 2009

Using G-deleted vesicular stomatitis virus to probe the innate anti-viral response.

J Virol Methods 2008 Nov 23;153(2):276-9. Epub 2008 Aug 23.

Department of Medical Sciences, Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, 1200 Main Street West, MDCL 5023, Hamilton, Ontario, Canada L8N 3Z5.

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http://dx.doi.org/10.1016/j.jviromet.2008.07.001DOI Listing
November 2008

A let-7 MicroRNA-sensitive vesicular stomatitis virus demonstrates tumor-specific replication.

Mol Ther 2008 Aug 17;16(8):1437-43. Epub 2008 Jun 17.

Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa Health Research Institute, Centre for Cancer Therapeutics, Ottawa, Ontario, Canada.

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http://dx.doi.org/10.1038/mt.2008.130DOI Listing
August 2008

Heterologous boosting of recombinant adenoviral prime immunization with a novel vesicular stomatitis virus-vectored tuberculosis vaccine.

Mol Ther 2008 Jun 25;16(6):1161-9. Epub 2008 Mar 25.

Department of Pathology and Molecular Medicine, Centre for Gene Therapeutics, McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1038/mt.2008.59DOI Listing
June 2008

Cigarette smoke suppresses type I interferon-mediated antiviral immunity in lung fibroblast and epithelial cells.

J Interferon Cytokine Res 2008 Mar;28(3):167-79

The Centre for Gene Therapeutics, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada L8N 3Z5.

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http://dx.doi.org/10.1089/jir.2007.0054DOI Listing
March 2008

Use of recombinant virus-vectored tuberculosis vaccines for respiratory mucosal immunization.

Tuberculosis (Edinb) 2006 May-Jul;86(3-4):211-7. Epub 2006 Feb 28.

Infectious Diseases Division, Centre for Gene Therapeutics and Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ont., Canada.

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http://dx.doi.org/10.1016/j.tube.2006.01.017DOI Listing
April 2007

Mucosal luminal manipulation of T cell geography switches on protective efficacy by otherwise ineffective parenteral genetic immunization.

J Immunol 2007 Feb;178(4):2387-95

Department of Pathology and Molecular Medicine and Division of Infectious Diseases, Center for Gene Therapeutics, McMaster University, Hamilton, Ontario, Canada.

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http://www.jimmunol.org/content/178/4/2387.full.pdf
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http://dx.doi.org/10.4049/jimmunol.178.4.2387DOI Listing
February 2007

Carrier cell-based delivery of an oncolytic virus circumvents antiviral immunity.

Mol Ther 2007 Jan;15(1):123-30

Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa Health Research Institute, Centre for Cancer Therapeutics, Ottawa, Ontario, Canada.

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http://dx.doi.org/10.1038/sj.mt.6300039DOI Listing
January 2007

Cigarette smoke impacts immune inflammatory responses to influenza in mice.

Am J Respir Crit Care Med 2006 Dec 5;174(12):1342-51. Epub 2006 Oct 5.

Department of Pathology and Molecular Medicine, Centre for Gene Therapeutics, McMaster University, Hamilton, ON, L8N 3Z5 Canada.

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http://www.atsjournals.org/doi/abs/10.1164/rccm.200604-561OC
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http://dx.doi.org/10.1164/rccm.200604-561OCDOI Listing
December 2006

Matrix protein of Vesicular stomatitis virus harbours a cryptic mitochondrial-targeting motif.

J Gen Virol 2006 Nov;87(Pt 11):3379-84

Centre for Gene Therapeutics, McMaster University, 1200 Main Street W MDCL-5023, Hamilton, ON L8N 3Z5, Canada.

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http://dx.doi.org/10.1099/vir.0.81762-0DOI Listing
November 2006

Vesicular stomatitis virus: re-inventing the bullet.

Trends Mol Med 2004 May;10(5):210-6

Ottawa Regional Cancer Centre Research Laboratories, Ottawa, Ontario K1H 1C4, Canada.

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http://dx.doi.org/10.1016/j.molmed.2004.03.003DOI Listing
May 2004