Publications by authors named "Brian C Wilson"

100Publications

First experience with spatial frequency domain imaging and red-light excitation of protoporphyrin IX fluorescence during tumor resection.

Biomed Opt Express 2020 Aug 15;11(8):4306-4315. Epub 2020 Jul 15.

Dartmouth College, Thayer School of Engineering, 14 Engineering Drive, Hanover, NH 03755, USA.

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http://dx.doi.org/10.1364/BOE.397507DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7449712PMC
August 2020

Characterization of pathological thyroid tissue using polarization-sensitive second harmonic generation microscopy.

Lab Invest 2020 Oct 31;100(10):1280-1287. Epub 2020 Jul 31.

Department of Physics, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1038/s41374-020-0475-7DOI Listing
October 2020

Singlet Oxygen Luminescence Image in Blood Vessels During Vascular-Targeted Photodynamic Therapy.

Photochem Photobiol 2020 05 20;96(3):646-651. Epub 2020 Apr 20.

Key Laboratory of OptoElectronic Science and Technology for Medicine of Ministry of Education, Fujian Provincial Key Laboratory for Photonics Technology, Fujian Normal University, Fuzhou, China.

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http://dx.doi.org/10.1111/php.13264DOI Listing
May 2020

The Yin and Yang of PDT and PTT.

Photochem Photobiol 2020 03 30;96(2):219-231. Epub 2019 Dec 30.

University Health Network/University of Toronto, Toronto, ON, M5G 1L7, Canada.

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http://dx.doi.org/10.1111/php.13184DOI Listing
March 2020

Design, synthesis and photocytotoxicity of upconversion nanoparticles: Potential applications for near-infrared photodynamic and photothermal therapy.

J Biophotonics 2019 11 23;12(11):e201900129. Epub 2019 Jul 23.

Department of Physics and Astronomy, University of Waterloo, Waterloo, Ontario, Canada.

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http://dx.doi.org/10.1002/jbio.201900129DOI Listing
November 2019

Photodynamic Therapy for the Treatment of Vertebral Metastases: A Phase I Clinical Trial.

Clin Cancer Res 2019 10 2;25(19):5766-5776. Epub 2019 Jul 2.

Holland Bone and Joint Program, Division of Orthopaedic Surgery, Sunnybrook Health Sciences; Orthopaedic Biomechanics Laboratory, Physical Sciences Platform, Sunnybrook Research Institute; and Department of Surgery, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1158/1078-0432.CCR-19-0673DOI Listing
October 2019

A Novel Laser Fiberscope for Simultaneous Imaging and Phototherapy of Peripheral Lung Cancer.

Chest 2019 09 26;156(3):571-578. Epub 2019 Apr 26.

Division of Thoracic Surgery, Toronto General Hospital, University Health Network, Toronto, ON, Canada; Princess Margaret Cancer Centre, University Health Network/University of Toronto, Toronto, ON, Canada; TECHNA Institute for the Advancement of Technology for Health, University Health Network, Toronto, ON, Canada; Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.chest.2019.04.010DOI Listing
September 2019

Development and first in-human use of a Raman spectroscopy guidance system integrated with a brain biopsy needle.

J Biophotonics 2019 03 28;12(3):e201800396. Epub 2019 Jan 28.

Department of Engineering Physics, Polytechnique Montreal, Montreal, Québec, Canada.

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http://doi.wiley.com/10.1002/jbio.201800396
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http://dx.doi.org/10.1002/jbio.201800396DOI Listing
March 2019

Non-invasive dynamic assessment of conjunctival melanomas by photoacoustic imaging.

Exp Eye Res 2019 02 14;179:157-167. Epub 2018 Nov 14.

Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, Ontario, Canada; Department of Laboratory Medicine and Pathobiology, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada; Department of Ophthalmology and Vision Sciences, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada; Department of Physics, Faculty of Science, Ryerson University, Toronto, Ontario, Canada; Faculty of Engineering and Architectural Science, Ryerson University, Toronto, Ontario, Canada; Institute of Biomedical Engineering, Science and Technology (iBEST), St. Michael's Hospital, Ryerson University, Toronto, Ontario, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00144835183060
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http://dx.doi.org/10.1016/j.exer.2018.11.014DOI Listing
February 2019

Feasibility of using spatial frequency-domain imaging intraoperatively during tumor resection.

J Biomed Opt 2018 10;24(7):1-6

Dartmouth College, Thayer School of Engineering, Hanover, New Hampshire, United States.

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http://dx.doi.org/10.1117/1.JBO.24.7.071608DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6995878PMC
October 2018

Quantitative subsurface spatial frequency-domain fluorescence imaging for enhanced glioma resection.

J Biophotonics 2019 05 20;12(5):e201800271. Epub 2019 Mar 20.

Princess Margaret Cancer Center, University Health Network, Toronto, Ontario, Canada.

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http://doi.wiley.com/10.1002/jbio.201800271
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http://dx.doi.org/10.1002/jbio.201800271DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470016PMC
May 2019

Optical and x-ray technology synergies enabling diagnostic and therapeutic applications in medicine.

J Biomed Opt 2018 10;23(12):1-17

University of Toronto, Princess Margaret Cancer Centre/University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1117/1.JBO.23.12.121610DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197862PMC
October 2018

Porphyrin-High-Density Lipoprotein: A Novel Photosensitizing Nanoparticle for Lung Cancer Therapy.

Ann Thorac Surg 2019 02 11;107(2):369-377. Epub 2018 Oct 11.

Division of Thoracic Surgery, Toronto General Hospital, University Health Network, Toronto, Ontario; Department of Medical Biophysics, University of Toronto, Toronto, Ontario; Guided Therapeutics, Princess Margaret Cancer Centre and TECHNA Institute, University Health Network, Toronto, Ontario; Institute of Biomaterial and Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00034975183146
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http://dx.doi.org/10.1016/j.athoracsur.2018.08.053DOI Listing
February 2019

Collagen chirality and three-dimensional orientation studied with polarimetric second-harmonic generation microscopy.

J Biophotonics 2019 01 14;12(1):e201800241. Epub 2018 Oct 14.

Department of Physics, University of Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/jbio.201800241DOI Listing
January 2019

High-Resolution Scanning Fiber Angioscopy as an Adjuvant to Fluoroscopy During Endovascular Interventions.

J Endovasc Ther 2018 Oct 20;25(5):617-623. Epub 2018 Aug 20.

3 Division of Vascular Surgery, St Michael's Hospital/University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1177/1526602818794663DOI Listing
October 2018

Challenges and opportunities in clinical translation of biomedical optical spectroscopy and imaging.

J Biomed Opt 2018 03;23(3):1-13

Polytechnique Montreal, Department of Engineering Physics, Montreal, Québec, Canada.

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http://dx.doi.org/10.1117/1.JBO.23.3.030901DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5838403PMC
March 2018

Biophotonics: the big picture.

J Biomed Opt 2017 12;23(2):1-7

University of Toronto, Princess Margaret Cancer Centre and Faculty of Medicine, Department of Medica, Canada.

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http://dx.doi.org/10.1117/1.JBO.23.2.021103DOI Listing
December 2017

Nanoparticle targeted folate receptor 1-enhanced photodynamic therapy for lung cancer.

Lung Cancer 2017 11 5;113:59-68. Epub 2017 Sep 5.

Division of Thoracic Surgery, Toronto General Hospital, University Health Network, Toronto, Canada; Institute of Biomaterial and Biomedical Engineering, University of Toronto, Canada; Guided Therapeutics, Princess Margaret Cancer Centre and TECHNA Institute, University Health Network, Canada; Division of Experimental Therapeutics, Respiratory & Critical Care, Princess Margaret Cancer Centre, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.lungcan.2017.09.002DOI Listing
November 2017

Challenges in translation: models to promote translation.

J Biomed Opt 2017 Oct;23(2):1-4

University Health Network/University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1117/1.JBO.23.2.021101DOI Listing
October 2017

Can photoacoustic imaging quantify surface-localized J-aggregating nanoparticles?

J Biomed Opt 2017 07;22(7):76008

University Health Network, Princess Margaret Cancer Centre, Toronto, Ontario, CanadabUniversity of Toronto, Department of Medical Biophysics, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1117/1.JBO.22.7.076008DOI Listing
July 2017

Preclinical evaluation of spatial frequency domain-enabled wide-field quantitative imaging for enhanced glioma resection.

J Biomed Opt 2017 07;22(7):76007

University of Toronto, Department of Medical Biophysics, Faculty of Medicine, Ontario, CanadabUniversity Health Network, Princess Margaret Cancer Center, Ontario, Canada.

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http://dx.doi.org/10.1117/1.JBO.22.7.076007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995142PMC
July 2017

Shape-based reconstruction for transrectal diffuse optical tomography monitoring of photothermal focal therapy of prostate cancer: simulation studies.

J Biomed Opt 2017 04;22(4):45004

University Health Network, Techna Institute, Toronto, Ontario, CanadaeUniversity of Toronto, Department of Medical Biophysics, Toronto, Ontario, CanadafUniversity Health Network, Ontario Cancer Institute, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1117/1.JBO.22.4.045004DOI Listing
April 2017

Changes of collagen ultrastructure in breast cancer tissue determined by second-harmonic generation double Stokes-Mueller polarimetric microscopy.

Biomed Opt Express 2016 Oct 15;7(10):4054-4068. Epub 2016 Sep 15.

Department of Physics and Institute for Optical Sciences, University of Toronto, 60 St. George Street, Toronto, ON M5S 1A7, Canada; Department of Chemical and Physical Sciences, University of Toronto Mississauga, 3359 Mississauga Road North, Mississauga, ON L5L 1C6, Canada.

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http://dx.doi.org/10.1364/BOE.7.004054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5102540PMC
October 2016

A review of Raman spectroscopy advances with an emphasis on clinical translation challenges in oncology.

Phys Med Biol 2016 12 2;61(23):R370-R400. Epub 2016 Nov 2.

Department of Neurology and Neurosurgery, Montreal Neurological Institute and Hospital, McGill University, 3801 University St., Montreal, QC H3A 2B4, Canada. Department of Engineering Physics, Polytechnique Montreal, CP 6079, Succ. Centre-Ville, Montreal, QC H3C 3A7, Canada. Imaging and Engineering, University of Montreal Hospital Research Center (CR-CHUM), 900 Rue Saint-Denis, Montréal, QC H2X 0A9, Canada.

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http://dx.doi.org/10.1088/0031-9155/61/23/R370DOI Listing
December 2016

Porphysome nanoparticles for enhanced photothermal therapy in a patient-derived orthotopic pancreas xenograft cancer model: a pilot study.

J Biomed Opt 2016 08;21(8):84002

University Health Network, Princess Margaret Cancer Center, 101 College Street, Toronto, Ontario M5G 1L7, CanadabUniversity of Toronto, Department of Medical Biophysics, 101 College Street, Toronto, Ontario M5G 1L7, CanadacPrincess Margaret Hospital, Department of Medical Oncology and Hematology, 610 University Avenue, Toronto, Ontario M5T 2M9, Canada.

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http://dx.doi.org/10.1117/1.JBO.21.8.084002DOI Listing
August 2016

An Integrated Nanotechnology-Enabled Transbronchial Image-Guided Intervention Strategy for Peripheral Lung Cancer.

Cancer Res 2016 10 19;76(19):5870-5880. Epub 2016 Aug 19.

Princess Margaret Cancer Centre and TECHNA Institute, University Health Network, Toronto, Ontario, Canada. Division of Thoracic Surgery, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5050138PMC
http://dx.doi.org/10.1158/0008-5472.CAN-15-3196DOI Listing
October 2016

A compact fiber-optic probe-based singlet oxygen luminescence detection system.

J Biophotonics 2017 02 25;10(2):320-326. Epub 2016 Jul 25.

Division of Electronic and Nanoscale Engineering, University of Glasgow, UK.

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http://dx.doi.org/10.1002/jbio.201600078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5266677PMC
February 2017

Controlling Spatial Heat and Light Distribution by Using Photothermal Enhancing Auto-Regulated Liposomes (PEARLs).

Angew Chem Int Ed Engl 2016 08 14;55(34):10003-7. Epub 2016 Jul 14.

Princess Margaret Cancer Centre and TECHNA Institute, University Health Network, Toronto, ON, M5G 1L7, Canada.

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http://dx.doi.org/10.1002/anie.201605241DOI Listing
August 2016

Optical clearing of melanoma in vivo: characterization by diffuse reflectance spectroscopy and optical coherence tomography.

J Biomed Opt 2016 Aug;21(8):081210

University of Toronto, Department of Medical Biophysics, Princess Margaret Cancer Research Tower, 101 College Street, Toronto, Ontario M5G 1L7, CanadacUniversity Health Network, Princess Margaret Cancer Center, Princess Margaret Cancer Research Tower, 101.

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http://dx.doi.org/10.1117/1.JBO.21.8.081210DOI Listing
August 2016

Diffuse Optical Spectroscopy for the Quantitative Assessment of Acute Ionizing Radiation Induced Skin Toxicity Using a Mouse Model.

J Vis Exp 2016 05 27(111). Epub 2016 May 27.

Department of Radiation Oncology, University of Toronto; Department of Medical Biophysics, University of Toronto.

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http://dx.doi.org/10.3791/53573DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4927719PMC
May 2016

Nanoparticle-Enabled Selective Destruction of Prostate Tumor Using MRI-Guided Focal Photothermal Therapy.

Prostate 2016 09 16;76(13):1169-81. Epub 2016 May 16.

Princess Margaret Cancer Center, UHN, Toronto, Canada.

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http://dx.doi.org/10.1002/pros.23203DOI Listing
September 2016

Photosensitized singlet oxygen generation and detection: Recent advances and future perspectives in cancer photodynamic therapy.

J Biophotonics 2016 12 2;9(11-12):1314-1325. Epub 2016 May 2.

Department of Medical Biophysics, University of Toronto/University Health Network, Toronto, Ontario M5G 1L7, Canada.

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http://dx.doi.org/10.1002/jbio.201600055DOI Listing
December 2016

X-ray induced singlet oxygen generation by nanoparticle-photosensitizer conjugates for photodynamic therapy: determination of singlet oxygen quantum yield.

Sci Rep 2016 Jan 28;6:19954. Epub 2016 Jan 28.

Australian Research Council Centre of Excellence for Nanoscale BioPhotonics, Department of Physics and Astronomy, Macquarie University, NSW 2109, Australia.

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http://dx.doi.org/10.1038/srep19954DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4730142PMC
January 2016

Stable J-aggregation enabled dual photoacoustic and fluorescence nanoparticles for intraoperative cancer imaging.

Nanoscale 2016 Jul 5;8(25):12618-25. Epub 2016 Jan 5.

Princess Margaret Cancer Centre and Techna Institute, University Health Network, Toronto, ON, Canada.

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http://dx.doi.org/10.1039/c5nr08165cDOI Listing
July 2016

Improved sensitivity to fluorescence for cancer detection in wide-field image-guided neurosurgery.

Biomed Opt Express 2015 Dec 30;6(12):5063-74. Epub 2015 Nov 30.

Dept. Engineering Physics, Polytechnique Montreal, CP 6079, Succ. Centre-Ville, Montreal, QC, H3C 3A7, Canada ; Centre de Recherche du Centre Hospitalier de l'Université de Montréal, rue Saint-Denis, Que, H2X 0A9, Canada.

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http://dx.doi.org/10.1364/BOE.6.005063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4679278PMC
December 2015

Quantitative spatial frequency fluorescence imaging in the sub-diffusive domain for image-guided glioma resection.

Biomed Opt Express 2015 Dec 19;6(12):4923-33. Epub 2015 Nov 19.

Department of Medical Biophysics, University of Toronto, 101 College Street, Toronto, ON M5G 1L7 Canada ; Princess Margaret Cancer Center/University Health Network, 610 University Avenue, Toronto, ON M5G 2M3 Canada.

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http://dx.doi.org/10.1364/BOE.6.004923DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4679266PMC
December 2015

Sensitivity analysis aimed at blood vessels detection using interstitial optical tomography during brain needle biopsy procedures.

Biomed Opt Express 2015 Nov 5;6(11):4238-54. Epub 2015 Oct 5.

Department of Engineering Physics, Polytechnique Montreal, 2900 blvd Edouard-Montpetit, Campus de l'Université de Montréal, Montreal, Que, H3T 1J4, Canada ; Centre de Recherche du Centre Hospitalier de l'Université de Montréal, rue Saint-Denis, Que, Canada.

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http://dx.doi.org/10.1364/BOE.6.004238DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4646534PMC
November 2015

Ultrastructural features of collagen in thyroid carcinoma tissue observed by polarization second harmonic generation microscopy.

Biomed Opt Express 2015 Sep 21;6(9):3475-81. Epub 2015 Aug 21.

Princess Margaret Cancer Centre, University Health Network, 101 College Street, Toronto, ON M5G 1L7, Canada.

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https://www.osapublishing.org/abstract.cfm?URI=boe-6-9-3475
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http://dx.doi.org/10.1364/BOE.6.003475DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4574672PMC
September 2015

In situ conversion of porphyrin microbubbles to nanoparticles for multimodality imaging.

Nat Nanotechnol 2015 Apr 30;10(4):325-32. Epub 2015 Mar 30.

1] Princess Margaret Cancer Center and Techna Institute, University Health Network, Toronto, Ontario M5G 2M9, Canada [2] Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5G 1L7, Canada [3] Department of Pharmaceutical Sciences, University of Toronto, Toronto, Ontario M5S 3M2, Canada [4] Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario M5G 1L7, Canada.

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http://dx.doi.org/10.1038/nnano.2015.25DOI Listing
April 2015

Nano-enabled SERS reporting photosensitizers.

Theranostics 2015 6;5(5):469-76. Epub 2015 Feb 6.

1. Princess Margaret Cancer Centre, UHN, Toronto, Ontario, Canada ; 2. Medical Biophysics, University of Toronto, Toronto, Ontario, Canada ; 3. Department of Pharmaceutical Sciences, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.7150/thno.10694DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4350009PMC
December 2015

Activation kinetics of zipper molecular beacons.

J Phys Chem B 2015 Jan 18;119(1):44-53. Epub 2014 Dec 18.

Department of Medical Biophysics, Ontario Cancer Institute, University of Toronto , Toronto, Ontario, Canada M5G 1L7.

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http://dx.doi.org/10.1021/jp5086813DOI Listing
January 2015

Relaxin peptide hormones are protective during the early stages of ischemic stroke in male rats.

Endocrinology 2015 Feb 2;156(2):638-46. Epub 2014 Dec 2.

Department of Biomedical Sciences (L.H.B., J.M.W., F.J.A., A.J.S.S.), Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada N1G2W1; Department of Biomedical Sciences (B.J.C., T.M.S.), Atlantic Veterinary College, University of Prince Edward Island, Charlottetown, Prince Edward Island, Canada C1A4P3; and Department of Biology (B.C.W.), Acadia University, Wolfville, Nova Scotia, Canada B4P2R6.

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http://dx.doi.org/10.1210/en.2014-1676DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4298330PMC
February 2015

Characterization of collagen in non-small cell lung carcinoma with second harmonic polarization microscopy.

Biomed Opt Express 2014 Oct 11;5(10):3562-7. Epub 2014 Sep 11.

Department of Physics and Institute for Optical Sciences, University of Toronto, 60 Saint George Street, Toronto, ON M5S1A7, Canada ; Chemical and Physical Sciences, University of Toronto Mississauga, 3359 Mississauga Road North, Mississauga, ON L5L1C6, Canada.

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http://dx.doi.org/10.1364/BOE.5.003562DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4206324PMC
October 2014

In vitro and in vivo effects of photodynamic therapy on metastatic breast cancer cells pre-treated with zoledronic acid.

Photodiagnosis Photodyn Ther 2014 Sep 15;11(3):426-33. Epub 2014 May 15.

Orthopaedic Biomechanics Laboratory, Sunnybrook Research Institute, 2075 Bayview Avenue, Toronto, ON, Canada M4N 3M5. Electronic address:

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http://dx.doi.org/10.1016/j.pdpdt.2014.04.002DOI Listing
September 2014

Wide-field multiplexed imaging of EGFR-targeted cancers using topical application of NIR SERS nanoprobes.

Nanomedicine (Lond) 2015 Jan 21;10(1):89-101. Epub 2014 Jul 21.

Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.

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https://www.futuremedicine.com/doi/10.2217/nnm.14.80
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http://dx.doi.org/10.2217/nnm.14.80DOI Listing
January 2015

Quantitative monitoring of radiation induced skin toxicities in nude mice using optical biomarkers measured from diffuse optical reflectance spectroscopy.

Biomed Opt Express 2014 May 1;5(5):1309-20. Epub 2014 Apr 1.

Department of Physics, Ryerson University, Ontario, Canada ; Department of Medical Physics, Odette Cancer Centre, Sunnybrook Health Sciences Centre Canada ; Department of Radiation Oncology, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1364/BOE.5.001309DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4026905PMC
May 2014

Orthotopic lung cancer murine model by nonoperative transbronchial approach.

Ann Thorac Surg 2014 May;97(5):1771-5

Division of Thoracic Surgery, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada; Latner Thoracic Surgery Research Laboratories, University Health Network, University of Toronto, Toronto, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.athoracsur.2014.01.048DOI Listing
May 2014

High-resolution angioscopic imaging during endovascular neurosurgery.

Neurosurgery 2014 Aug;75(2):171-80; discussion 179-80

*Department of Medical Biophysics, University of Toronto; ‡Department of Medical Imaging, Toronto Western Hospital, University Health Network; §Radiation Medicine Program, Princess Margaret Cancer Centre; ¶Techna Institute, University Health Network, Toronto, Ontario, Canada; ‖Department of Medical Imaging, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada; #Department of Mechanical Engineering, University of Washington, Seattle, Washington; **Department of Surgery, Division of Neurosurgery, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1227/NEU.0000000000000383DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4086773PMC
August 2014

Aggregate enhanced trimodal porphyrin shell microbubbles for ultrasound, photoacoustic, and fluorescence imaging.

Bioconjug Chem 2014 Apr 20;25(4):796-801. Epub 2014 Mar 20.

Princess Margaret Cancer Centre and Techna Institute, University Health Network , Toronto, Ontario M5G1L7, Canada.

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http://dx.doi.org/10.1021/bc5000725DOI Listing
April 2014

Evaluation of one- and two-photon activated photodynamic therapy with pyropheophorbide-a methyl ester in human cervical, lung and ovarian cancer cells.

J Photochem Photobiol B 2014 Mar 15;132:102-10. Epub 2014 Feb 15.

Department of Physics and Astronomy, University of Waterloo, 200 University Avenue West, Waterloo, ON N2L 3G1, Canada; Departments of Biology and Chemistry, University of Waterloo, 200 University Avenue West, Waterloo, ON N2L 3G1, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jphotobiol.2014.02.002DOI Listing
March 2014

Focused ultrasound delivery of Raman nanoparticles across the blood-brain barrier: potential for targeting experimental brain tumors.

Nanomedicine 2014 Jul 27;10(5):1075-87. Epub 2013 Dec 27.

The Hospital for Sick Children, Arthur & Sonia Labatt Brain Tumour Research Centre, Toronto, Canada; Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, Canada; Department of Laboratory Medicine & Pathobiology, University of Toronto, Toronto, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.nano.2013.12.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4074278PMC
July 2014

Optical glucose analogs of aminolevulinic acid for fluorescence-guided tumor resection and photodynamic therapy.

Mol Imaging Biol 2014 Aug;16(4):495-503

Ontario Cancer Institute, University Heath Network, Toronto, Ontario, Canada,

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http://dx.doi.org/10.1007/s11307-013-0687-yDOI Listing
August 2014

System and methods for wide-field quantitative fluorescence imaging during neurosurgery.

Opt Lett 2013 Aug;38(15):2786-8

Section of Neurosurgery, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA.

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http://dx.doi.org/10.1364/OL.38.002786DOI Listing
August 2013

5-Aminolevulinic acid-induced protoporphyrin IX fluorescence in meningioma: qualitative and quantitative measurements in vivo.

Neurosurgery 2014 Mar;10 Suppl 1:74-82; discussion 82-3

*Section of Neurosurgery, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire; ‡Thayer School of Engineering, Hanover, New Hampshire; §Geisel School of Medicine at Dartmouth, Hanover, New Hampshire; ‖Departments of Pathology and Neurology, Georgetown University Medical Center, Washington, DC; ¶Ontario Cancer Institute, University of Toronto, Toronto, Ontario, Canada; #Engineering Physics Department, École Polytechnique de Montréal, Montreal, Quebec, Canada; **Norris Cotton Cancer Center, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire.

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http://dx.doi.org/10.1227/NEU.0000000000000117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4237006PMC
March 2014

Biologically-targeted detection of primary and micro-metastatic ovarian cancer.

Theranostics 2013 25;3(6):420-7. Epub 2013 May 25.

Department of Medical Biophysics, Princess Margarete Cancer Center, University of Toronto, Toronto, Canada.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3677412PMC
January 2014

The benefits of photodynamic therapy on vertebral bone are maintained and enhanced by combination treatment with bisphosphonates and radiation therapy.

J Orthop Res 2013 Sep 26;31(9):1398-405. Epub 2013 Apr 26.

Orthopaedic Biomechanics Laboratory, Sunnybrook Research Institute, UB-55, 2075 Bayview Avenue, Toronto, Ontario, M4N 3M5, Canada.

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September 2013

Widefield quantitative multiplex surface enhanced Raman scattering imaging in vivo.

J Biomed Opt 2013 Apr;18(4):046011

University of Toronto, Department of Medical Biophysics, Toronto, Ontario, Canada.

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April 2013

Inherently multimodal nanoparticle-driven tracking and real-time delineation of orthotopic prostate tumors and micrometastases.

ACS Nano 2013 May 5;7(5):4221-32. Epub 2013 Apr 5.

Ontario Cancer Institute, Campbell Family Institute for Cancer Research and Techna Institute, UHN, 610 University Avenue, Toronto, ON Canada M5G 2M9.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3667620PMC
May 2013

Singlet oxygen luminescence detection with a fiber-coupled superconducting nanowire single-photon detector.

Opt Express 2013 Feb;21(4):5005-13

Scottish Universities Physics Alliance and School of Engineering and Physical Sciences, Heriot-Watt University, Edinburgh, EH14 4AS, UK.

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February 2013

Intrinsically copper-64-labeled organic nanoparticles as radiotracers.

Angew Chem Int Ed Engl 2012 Dec 14;51(52):13128-31. Epub 2012 Nov 14.

Ontario Cancer Institute, Campbell Family Institute for Cancer Research, UHN, Canada.

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December 2012

Quantitative, spectrally-resolved intraoperative fluorescence imaging.

Sci Rep 2012 12;2:798. Epub 2012 Nov 12.

Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA.

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April 2013

Feasibility study on quantitative measurements of singlet oxygen generation using singlet oxygen sensor green.

J Fluoresc 2013 Jan 23;23(1):41-7. Epub 2012 Aug 23.

Key Laboratory of OptoElectronic Science and Technology for Medicine of Ministry of Education, Fujian Normal University, Fujian 350007, China.

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January 2013

Porphyrin-lipid stabilized gold nanoparticles for surface enhanced Raman scattering based imaging.

Bioconjug Chem 2012 Sep 16;23(9):1726-30. Epub 2012 Aug 16.

Ontario Cancer Institute, Campbell Family Cancer Research Institute, University of Toronto, Toronto, Ontario, Canada.

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September 2012

Porphyrin shell microbubbles with intrinsic ultrasound and photoacoustic properties.

J Am Chem Soc 2012 Oct 1;134(40):16464-7. Epub 2012 Aug 1.

Ontario Cancer Institute and Techna Institute, University Health Network, Toronto, Ontario, Canada M5G 1L7.

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October 2012