Publications by authors named "Brian C Smith"

41Publications

Development of activity-based probes for the protein deacylase Sirt1.

Bioorg Chem 2020 Aug 26;104:104232. Epub 2020 Aug 26.

Department of Biochemistry, Program in Chemical Biology, Medical College of Wisconsin, Milwaukee, WI 53226, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bioorg.2020.104232DOI Listing
August 2020

ICEKAT: an interactive online tool for calculating initial rates from continuous enzyme kinetic traces.

BMC Bioinformatics 2020 May 14;21(1):186. Epub 2020 May 14.

Department of Biochemistry, Medical College of Wisconsin, 8701 Watertown Plank Rd., Milwaukee, 53226, USA.

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http://dx.doi.org/10.1186/s12859-020-3513-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7222511PMC
May 2020

Human sirtuins are differentially sensitive to inhibition by nitrosating agents and other cysteine oxidants.

J Biol Chem 2020 Jun 5;295(25):8524-8536. Epub 2020 May 5.

Department of Biochemistry, Medical College of Wisconsin, Milwaukee, Wisconsin, USA

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http://dx.doi.org/10.1074/jbc.RA119.011988DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7307208PMC
June 2020

Validation and Characterization of Five Distinct Novel Inhibitors of Human Cytomegalovirus.

J Med Chem 2020 04 27;63(8):3896-3907. Epub 2020 Mar 27.

Department of Pediatrics, Division of Infectious Disease, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, United States.

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http://dx.doi.org/10.1021/acs.jmedchem.9b01501DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7386824PMC
April 2020

Non-sedating benzodiazepines cause paralysis and tissue damage in the parasitic blood fluke Schistosoma mansoni.

PLoS Negl Trop Dis 2019 11 15;13(11):e0007826. Epub 2019 Nov 15.

Department of Cell Biology, Neurobiology & Anatomy, Medical College of Wisconsin, Milwaukee, WI, United States of America.

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http://dx.doi.org/10.1371/journal.pntd.0007826DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6881066PMC
November 2019

Calmodulin-induced Conformational Control and Allostery Underlying Neuronal Nitric Oxide Synthase Activation.

J Mol Biol 2018 03 17;430(7):935-947. Epub 2018 Feb 17.

Roy J. Carver Department of Biochemistry, Biophysics, and Molecular Biology, Iowa State University, Ames, IA 50011, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jmb.2018.02.003DOI Listing
March 2018

Nitric oxide antagonism to glioblastoma photodynamic therapy and mitigation thereof by BET bromodomain inhibitor JQ1.

J Biol Chem 2018 04 12;293(14):5345-5359. Epub 2018 Feb 12.

From the Department of Biochemistry, Medical College of Wisconsin, Milwaukee, Wisconsin 53226-3548

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http://dx.doi.org/10.1074/jbc.RA117.000443DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5892570PMC
April 2018

Development and Validation of 2D Difference Intensity Analysis for Chemical Library Screening by Protein-Detected NMR Spectroscopy.

Chembiochem 2018 03 25;19(5):448-458. Epub 2018 Jan 25.

Department of Biochemistry, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI, 53226, USA.

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http://dx.doi.org/10.1002/cbic.201700386DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5844354PMC
March 2018

Metabolically Derived Lysine Acylations and Neighboring Modifications Tune the Binding of the BET Bromodomains to Histone H4.

Biochemistry 2017 10 5;56(41):5485-5495. Epub 2017 Oct 5.

Department of Biochemistry, Medical College of Wisconsin , Milwaukee, Wisconsin 53226, United States.

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http://pubs.acs.org/doi/10.1021/acs.biochem.7b00595
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http://dx.doi.org/10.1021/acs.biochem.7b00595DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5970795PMC
October 2017

Mechanism of Sirt1 NAD+-dependent Protein Deacetylase Inhibition by Cysteine S-Nitrosation.

J Biol Chem 2016 Dec 18;291(49):25398-25410. Epub 2016 Oct 18.

From the Department of Biochemistry, Medical College of Wisconsin, Milwaukee, Wisconsin 53226

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http://dx.doi.org/10.1074/jbc.M116.754655DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5207242PMC
December 2016

Nitrosothiol formation and S-nitrosation signaling through nitric oxide synthases.

Nitric Oxide 2017 Feb 5;63:52-60. Epub 2016 Oct 5.

Department of Biochemistry and Redox Biology Program, Medical College of Wisconsin, Milwaukee, WI, USA. Electronic address:

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http://dx.doi.org/10.1016/j.niox.2016.10.001DOI Listing
February 2017

Molecular architecture of mammalian nitric oxide synthases.

Proc Natl Acad Sci U S A 2014 Sep 14;111(35):E3614-23. Epub 2014 Aug 14.

Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037

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http://dx.doi.org/10.1073/pnas.1413763111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4156747PMC
September 2014

Nitric oxide synthase domain interfaces regulate electron transfer and calmodulin activation.

Proc Natl Acad Sci U S A 2013 Sep 3;110(38):E3577-86. Epub 2013 Sep 3.

Departments of Chemistry and Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037.

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http://dx.doi.org/10.1073/pnas.1313331110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3780838PMC
September 2013

Mechanisms of S-nitrosothiol formation and selectivity in nitric oxide signaling.

Curr Opin Chem Biol 2012 Dec 3;16(5-6):498-506. Epub 2012 Nov 3.

Department of Chemistry, The Scripps Research Institute, La Jolla, CA, United States.

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https://linkinghub.elsevier.com/retrieve/pii/S13675931120010
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http://dx.doi.org/10.1016/j.cbpa.2012.10.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518608PMC
December 2012

Mechanisms of S-nitrosothiol formation and selectivity in nitric oxide signaling.

Curr Opin Chem Biol 2012 Dec 3;16(5-6):498-506. Epub 2012 Nov 3.

Department of Chemistry, The Scripps Research Institute, La Jolla, CA, United States.

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https://linkinghub.elsevier.com/retrieve/pii/S13675931120010
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http://dx.doi.org/10.1016/j.cbpa.2012.10.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518608PMC
December 2012

Structural and kinetic isotope effect studies of nicotinamidase (Pnc1) from Saccharomyces cerevisiae.

Biochemistry 2012 Jan 29;51(1):243-56. Epub 2011 Dec 29.

Department of Biomolecular Chemistry, University of Wisconsin, Madison, Wisconsin 53706, United States.

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http://dx.doi.org/10.1021/bi2015508DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257521PMC
January 2012

Hydrolysis of O-acetyl-ADP-ribose isomers by ADP-ribosylhydrolase 3.

J Biol Chem 2011 Jun 17;286(24):21110-7. Epub 2011 Apr 17.

Cardiovascular and Pulmonary Branch, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M111.237636
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http://dx.doi.org/10.1074/jbc.M111.237636DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3122172PMC
June 2011

SIRT3 substrate specificity determined by peptide arrays and machine learning.

ACS Chem Biol 2011 Feb 1;6(2):146-57. Epub 2010 Nov 1.

Department of Biomolecular Chemistry, University of Wisconsin-Madison , Madison, Wisconsin 53706, United States.

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http://dx.doi.org/10.1021/cb100218dDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3042044PMC
February 2011

A continuous microplate assay for sirtuins and nicotinamide-producing enzymes.

Anal Biochem 2009 Nov 16;394(1):101-9. Epub 2009 Jul 16.

Department of Biomolecular Chemistry, University of Wisconsin-Madison, Madison, WI 53706, USA.

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http://dx.doi.org/10.1016/j.ab.2009.07.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2752052PMC
November 2009

Ure(k)a! Sirtuins Regulate Mitochondria.

Cell 2009 May;137(3):404-6

Department of Biomolecular Chemistry, University of Wisconsin School of Medicine and Public Health, Madison, 53706, USA.

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http://dx.doi.org/10.1016/j.cell.2009.04.036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3310393PMC
May 2009

Mechanisms and molecular probes of sirtuins.

Chem Biol 2008 Oct;15(10):1002-13

Department of Biomolecular Chemistry, University of Wisconsin Medical School, Madison, WI 53706, USA.

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http://dx.doi.org/10.1016/j.chembiol.2008.09.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2626554PMC
October 2008

Chemical mechanisms of histone lysine and arginine modifications.

Biochim Biophys Acta 2009 Jan 14;1789(1):45-57. Epub 2008 Jun 14.

Department of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA.

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http://dx.doi.org/10.1016/j.bbagrm.2008.06.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2642981PMC
January 2009

Mechanism-based inhibition of Sir2 deacetylases by thioacetyl-lysine peptide.

Biochemistry 2007 Dec 21;46(50):14478-86. Epub 2007 Nov 21.

Department of Chemistry, University of Wisconsin, Madison, Wisconsin 53706-1532, USA.

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http://dx.doi.org/10.1021/bi7013294DOI Listing
December 2007

Acetyl-lysine analog peptides as mechanistic probes of protein deacetylases.

J Biol Chem 2007 Dec 19;282(51):37256-65. Epub 2007 Oct 19.

Department of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706-1532, USA.

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http://dx.doi.org/10.1074/jbc.M707878200DOI Listing
December 2007

Linking SIRT2 to Parkinson's disease.

ACS Chem Biol 2007 Aug;2(8):529-32

Department of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA.

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http://dx.doi.org/10.1021/cb700160dDOI Listing
August 2007

Sir2 deacetylases exhibit nucleophilic participation of acetyl-lysine in NAD+ cleavage.

J Am Chem Soc 2007 May 17;129(18):5802-3. Epub 2007 Apr 17.

Department of Biomolecular Chemistry, University of Wisconsin-Madison, 1300 University Avenue, Madison, Wisconsin 53706, USA.

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http://dx.doi.org/10.1021/ja070162wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2568996PMC
May 2007

Sirtuins caught in the act.

Structure 2006 Aug;14(8):1207-8

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http://dx.doi.org/10.1016/j.str.2006.07.004DOI Listing
August 2006

Sir2 protein deacetylases: evidence for chemical intermediates and functions of a conserved histidine.

Biochemistry 2006 Jan;45(1):272-82

Department of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA.

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http://dx.doi.org/10.1021/bi052014tDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2519119PMC
January 2006

Small molecule regulation of Sir2 protein deacetylases.

FEBS J 2005 Sep;272(18):4607-16

Department of Biomolecular Chemistry, University of Wisconsin, Madison, WI 53706-1532, USA.

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http://dx.doi.org/10.1111/j.1742-4658.2005.04862.xDOI Listing
September 2005

Mechanism of human SIRT1 activation by resveratrol.

J Biol Chem 2005 Apr 4;280(17):17187-95. Epub 2005 Mar 4.

Department of Biomolecular Chemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M501250200
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http://dx.doi.org/10.1074/jbc.M501250200DOI Listing
April 2005

Coenzyme specificity of Sir2 protein deacetylases: implications for physiological regulation.

J Biol Chem 2004 Sep 21;279(38):40122-9. Epub 2004 Jul 21.

Department of Biomolecular Chemistry, University of Wisconsin, Madison, Wisconsin 53706-1532, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M407484200
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http://dx.doi.org/10.1074/jbc.M407484200DOI Listing
September 2004