Brian C Kraemer

Brian C Kraemer

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Brian C Kraemer

Brian C Kraemer

Publications by authors named "Brian C Kraemer"

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Constitutive XBP-1s-mediated activation of the endoplasmic reticulum unfolded protein response protects against pathological tau.

Nat Commun 2019 Sep 30;10(1):4443. Epub 2019 Sep 30.

Molecular and Cellular Biology Interdisciplinary Program, University of Washington, Seattle, WA, 98195, USA.

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http://dx.doi.org/10.1038/s41467-019-12070-3DOI Listing
September 2019

Tau tubulin kinases in proteinopathy.

FEBS J 2019 Jul 22;286(13):2434-2446. Epub 2019 May 22.

Division of Gerontology and Geriatric Medicine, Department of Medicine, University of Washington, Seattle, WA, USA.

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https://onlinelibrary.wiley.com/doi/abs/10.1111/febs.14866
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http://dx.doi.org/10.1111/febs.14866DOI Listing
July 2019

α-Methyl-α-phenylsuccinimide ameliorates neurodegeneration in a C. elegans model of TDP-43 proteinopathy.

Neurobiol Dis 2018 10 22;118:40-54. Epub 2018 Jun 22.

Department of Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2018.06.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097874PMC
October 2018

DOPA Decarboxylase Modulates Tau Toxicity.

Biol Psychiatry 2018 03 15;83(5):438-446. Epub 2017 Jun 15.

Geriatrics Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle Division, Washington; Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington; Department of Pathology, University of Washington, Seattle, Washington; Division of Gerontology and Geriatric Medicine, Department of Medicine, University of Washington, Seattle, Washington. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00063223173166
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http://dx.doi.org/10.1016/j.biopsych.2017.06.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5732084PMC
March 2018

Pathological phosphorylation of tau and TDP-43 by TTBK1 and TTBK2 drives neurodegeneration.

Mol Neurodegener 2018 02 6;13(1). Epub 2018 Feb 6.

Geriatrics Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, S182, 1660 South Columbian Way, Seattle, WA, 98108, USA.

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http://dx.doi.org/10.1186/s13024-018-0237-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5802059PMC
February 2018

TDP-43/FUS in motor neuron disease: Complexity and challenges.

Prog Neurobiol 2016 Oct - Nov;145-146:78-97. Epub 2016 Sep 28.

Department of Radiation Oncology, Houston Methodist Research Institute, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1016/j.pneurobio.2016.09.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5101148PMC
June 2017

The phosphatase calcineurin regulates pathological TDP-43 phosphorylation.

Acta Neuropathol 2016 10 29;132(4):545-61. Epub 2016 Jul 29.

Geriatrics Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, 98108, USA.

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http://dx.doi.org/10.1007/s00401-016-1600-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5026939PMC
October 2016

Repetitive blast exposure in mice and combat veterans causes persistent cerebellar dysfunction.

Sci Transl Med 2016 Jan;8(321):321ra6

Geriatric Research Education and Clinical Center, VA Puget Sound Health Care System, Seattle, WA 98108, USA. Department of Medicine, University of Washington, Seattle, WA 98195, USA. Department of Pharmacology, University of Washington, Seattle, WA 98195, USA.

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http://dx.doi.org/10.1126/scitranslmed.aaa9585DOI Listing
January 2016

Erratum to: Ethosuximide ameliorates neurodegenerative disease phenotypes by modulating DAF-16/FOXO target gene expression.

Mol Neurodegener 2015 Oct 23;10:54. Epub 2015 Oct 23.

Department of Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Crown St, Liverpool, L69 3BX, UK.

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http://dx.doi.org/10.1186/s13024-015-0051-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4619536PMC
October 2015

Ethosuximide ameliorates neurodegenerative disease phenotypes by modulating DAF-16/FOXO target gene expression.

Mol Neurodegener 2015 Sep 29;10:51. Epub 2015 Sep 29.

Department of Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Crown St, Liverpool, L69 3BX, UK.

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http://dx.doi.org/10.1186/s13024-015-0046-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4587861PMC
September 2015

Molecular hydrogen in drinking water protects against neurodegenerative changes induced by traumatic brain injury.

PLoS One 2014 24;9(9):e108034. Epub 2014 Sep 24.

Geriatric Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, United States of America; Division of Gerontology and Geriatric Medicine, Department of Medicine, University of Washington, Seattle, WA, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0108034PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4176020PMC
June 2015

The tau tubulin kinases TTBK1/2 promote accumulation of pathological TDP-43.

PLoS Genet 2014 Dec 4;10(12):e1004803. Epub 2014 Dec 4.

Geriatric Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, Washington, United States of America; Department of Medicine, University of Washington, Seattle, Washington, United States of America; Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1004803DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4256087PMC
December 2014

CDC7 inhibition blocks pathological TDP-43 phosphorylation and neurodegeneration.

Ann Neurol 2013 Jul 8;74(1):39-52. Epub 2013 Jul 8.

Geriatric Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA; Department of Medicine, University of Washington, Seattle, WA.

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http://doi.wiley.com/10.1002/ana.23870
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http://dx.doi.org/10.1002/ana.23870DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3775949PMC
July 2013

Dopamine D2 receptor antagonism suppresses tau aggregation and neurotoxicity.

Biol Psychiatry 2013 Mar 7;73(5):464-71. Epub 2012 Nov 7.

Geriatrics Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S00063223120080
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http://dx.doi.org/10.1016/j.biopsych.2012.08.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3570611PMC
March 2013

Potential neuroprotective strategies against tauopathy.

Biochem Soc Trans 2012 Aug;40(4):656-60

Geriatric Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle Division, Seattle, WA 98108, USA.

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http://dx.doi.org/10.1042/BST20120017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5967400PMC
August 2012

Truncation of tau at E391 promotes early pathologic changes in transgenic mice.

J Neuropathol Exp Neurol 2011 Nov;70(11):1006-19

Mental Illness Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, Washington 98108, USA.

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http://dx.doi.org/10.1097/NEN.0b013e31823557fbDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3237612PMC
November 2011

Genetic strategies to study TDP-43 in rodents and to develop preclinical therapeutics for amyotrophic lateral sclerosis.

Eur J Neurosci 2011 Oct 21;34(8):1179-88. Epub 2011 Jul 21.

Department of Pharmacology, Toxicology, and Neuroscience, Louisiana State University Health Sciences Center, Shreveport, LA, USA.

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http://dx.doi.org/10.1111/j.1460-9568.2011.07803.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3196044PMC
October 2011

Proteasome inhibition drives HDAC6-dependent recruitment of tau to aggresomes.

J Mol Neurosci 2011 Sep 22;45(1):32-41. Epub 2011 Feb 22.

Geriatrics Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA.

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http://dx.doi.org/10.1007/s12031-011-9502-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3145040PMC
September 2011

MSUT2 is a determinant of susceptibility to tau neurotoxicity.

Hum Mol Genet 2011 May 25;20(10):1989-99. Epub 2011 Feb 25.

Geriatrics Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle Division, Seattle, WA 98108, USA.

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http://dx.doi.org/10.1093/hmg/ddr079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3080609PMC
May 2011

Phosphorylation promotes neurotoxicity in a Caenorhabditis elegans model of TDP-43 proteinopathy.

J Neurosci 2010 Dec;30(48):16208-19

Geriatrics Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, Washington 98108, USA.

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http://www.jneurosci.org/cgi/doi/10.1523/JNEUROSCI.2911-10.2
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http://dx.doi.org/10.1523/JNEUROSCI.2911-10.2010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3075589PMC
December 2010

The role of MSUT-2 in tau neurotoxicity: a target for neuroprotection in tauopathy?

Biochem Soc Trans 2010 Aug;38(4):973-6

Geriatric Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle Division, 1660 S Colombian Way, Seattle, WA 98108, USA.

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http://www.biochemsoctrans.org/content/ppbiost/38/4/973.full
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http://biochemsoctrans.org/lookup/doi/10.1042/BST0380973
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http://dx.doi.org/10.1042/BST0380973DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3103713PMC
August 2010

Loss of murine TDP-43 disrupts motor function and plays an essential role in embryogenesis.

Acta Neuropathol 2010 Apr 3;119(4):409-19. Epub 2010 Mar 3.

Geriatrics Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA.

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http://dx.doi.org/10.1007/s00401-010-0659-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2880609PMC
April 2010

SUT-2 potentiates tau-induced neurotoxicity in Caenorhabditis elegans.

Hum Mol Genet 2009 May 9;18(10):1825-38. Epub 2009 Mar 9.

Geriatrics Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA.

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http://dx.doi.org/10.1093/hmg/ddp099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2722225PMC
May 2009

SUT-1 enables tau-induced neurotoxicity in C. elegans.

Hum Mol Genet 2007 Aug 18;16(16):1959-71. Epub 2007 Jun 18.

Geriatrics Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA.

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http://dx.doi.org/10.1093/hmg/ddm143DOI Listing
August 2007

Molecular pathways that influence human tau-induced pathology in Caenorhabditis elegans.

Hum Mol Genet 2006 May 6;15(9):1483-96. Epub 2006 Apr 6.

Geriatrics Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108-1597, USA.

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http://dx.doi.org/10.1093/hmg/ddl067DOI Listing
May 2006

Neurodegeneration and defective neurotransmission in a Caenorhabditis elegans model of tauopathy.

Proc Natl Acad Sci U S A 2003 Aug 18;100(17):9980-5. Epub 2003 Jul 18.

Geriatrics Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108-1597, USA.

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http://dx.doi.org/10.1073/pnas.1533448100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC187908PMC
August 2003