Brian C Jensen

Brian C Jensen

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Brian C Jensen

Brian C Jensen

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The nuclear receptor RORα protects against angiotensin II-induced cardiac hypertrophy and heart failure.

Am J Physiol Heart Circ Physiol 2019 Jan 2;316(1):H186-H200. Epub 2018 Nov 2.

McAllister Heart Institute University of North Carolina School of Medicine , Chapel Hill, North Carolina.

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https://www.physiology.org/doi/10.1152/ajpheart.00531.2018
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http://dx.doi.org/10.1152/ajpheart.00531.2018DOI Listing
January 2019

Correction to: Quantitative trait mapping in Diversity Outbred mice identifies two genomic regions associated with heart size.

Mamm Genome 2018 Dec 4. Epub 2018 Dec 4.

Division of Cardiology, Department of Medicine, University of North Carolina, 6012 Burnett-Womack Building, Chapel Hill, NC, 27599, USA.

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http://dx.doi.org/10.1007/s00335-018-9789-9DOI Listing
December 2018

Practical guidance on the use of sacubitril/valsartan for heart failure.

Heart Fail Rev 2018 Dec 18. Epub 2018 Dec 18.

Department of Medicine, Division of Cardiology, Washington University in St Louis, St Louis, MO, USA.

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http://dx.doi.org/10.1007/s10741-018-9757-1DOI Listing
December 2018

Effect of 6-min Walk Test on pro-BNP Levels in Patients with Pulmonary Arterial Hypertension.

Lung 2018 06 21;196(3):315-319. Epub 2018 Mar 21.

Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of North Carolina, Chapel Hill, USA.

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http://dx.doi.org/10.1007/s00408-018-0111-0DOI Listing
June 2018

Quantitative trait mapping in Diversity Outbred mice identifies two genomic regions associated with heart size.

Mamm Genome 2018 02 26;29(1-2):80-89. Epub 2017 Dec 26.

Division of Cardiology, Department of Medicine, University of North Carolina, 6012 Burnett-Womack Building, Chapel Hill, NC, 27599, USA.

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http://dx.doi.org/10.1007/s00335-017-9730-7DOI Listing
February 2018

Clinical Evidence Supports a Protective Role for CXCL5 in Coronary Artery Disease.

Am J Pathol 2017 Dec 16;187(12):2895-2911. Epub 2017 Nov 16.

McAllister Heart Institute, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; Department of Pathology and Laboratory Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; Department of Pharmacology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2017.08.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5718092PMC
December 2017

Cardiovascular Effects of the MEK Inhibitor, Trametinib: A Case Report, Literature Review, and Consideration of Mechanism.

Cardiovasc Toxicol 2017 Oct;17(4):487-493

Department of Medicine, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

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http://dx.doi.org/10.1007/s12012-017-9425-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319910PMC
October 2017

Early cardiac perfusion defects after left-sided radiation therapy for breast cancer: is there a volume response?

Breast Cancer Res Treat 2017 Jul 21;164(2):253-262. Epub 2017 Apr 21.

Department of Radiation Oncology, University of North Carolina, Chapel Hill, NC, USA.

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http://dx.doi.org/10.1007/s10549-017-4248-yDOI Listing
July 2017

Whole Exome Sequencing Identifies Truncating Variants in Nuclear Envelope Genes in Patients With Cardiovascular Disease.

Circ Cardiovasc Genet 2017 Jun;10(3)

From the Department of Pathology, Duke University, Durham, NC (G.T.H.); Division of Cardiology (B.C.J.), McAllister Heart Institute (B.C.J., L.A.S., W.H., J.L.), Department of Cell and Molecular Physiology (L.A.S., W.H., J.L.), Department of Genetics (D.M., C.S., C.T., B.A.S., E.A.R.-M., B.K., K.C.W., K.E.W., J.P.E., J.S.B.), Department of Pathology and Laboratory Medicine (J.L., K.E.W.), UNC School of Medicine, Chapel Hill; Renaissance Computing Institute, Chapel Hill, NC (K.C.W.); and ECU Heart Institute, Brody School of Medicine, Greenville, NC (H.A.).

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http://dx.doi.org/10.1161/CIRCGENETICS.116.001443DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5497793PMC
June 2017

Cardiac Toxicity After Radiotherapy for Stage III Non-Small-Cell Lung Cancer: Pooled Analysis of Dose-Escalation Trials Delivering 70 to 90 Gy.

J Clin Oncol 2017 May 23;35(13):1387-1394. Epub 2017 Jan 23.

Kyle Wang, Michael J. Eblan, Matthew Lipner, Timothy M. Zagar, Panayiotis Mavroidis, Carrie B. Lee, Brian C. Jensen, Julian G. Rosenman, and Lawrence B. Marks, University of North Carolina Hospitals; Allison M. Deal and Yue Wang, Lineberger Comprehensive Cancer Center Biostatistics Core, University of North Carolina Hospitals, Chapel Hill; Thomas E. Stinchcombe, Duke University Hospitals, Durham, NC; and Mark A. Socinski, Florida Hospital Cancer Institute, Orlando, FL.

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http://dx.doi.org/10.1200/JCO.2016.70.0229DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5455462PMC
May 2017

BRG1 and BRM function antagonistically with c-MYC in adult cardiomyocytes to regulate conduction and contractility.

J Mol Cell Cardiol 2017 04 21;105:99-109. Epub 2017 Feb 21.

Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00222828173004
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http://dx.doi.org/10.1016/j.yjmcc.2017.02.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5415084PMC
April 2017

Left Ventricular Dysfunction After Treatment With Ipilimumab for Metastatic Melanoma.

Am J Ther 2016 Nov/Dec;23(6):e1925-e1928

1Department of Pharmacy, University of North Carolina Medical Center, Chapel Hill, NC; 2Division of Cardiology, University of North Carolina Medical Center, Chapel Hill, NC; 3UNC School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC; 4UNC McAllister Heart Institute, Chapel Hill, NC; 5Center for Heart and Vascular Care, University of North Carolina Medical Center, Chapel Hill, NC; 6Department of Medicine, University of North Carolina Medical Center, Chapel Hill, NC; and 7Lineberger Comprehensive Cancer Center, Chapel Hill, NC.

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http://dx.doi.org/10.1097/MJT.0000000000000430DOI Listing
February 2017

Family presence and participation during medical visits of heart failure patients: An analysis of survey and audiotaped communication data.

Patient Educ Couns 2017 02 3;100(2):250-258. Epub 2016 Sep 3.

Cecil G. Sheps Center for Health Services Research, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA; Department of Social Medicine, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA; Center for Health Equity Research, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA.

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http://dx.doi.org/10.1016/j.pec.2016.09.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5322738PMC
February 2017

An Oral Selective Alpha-1A Adrenergic Receptor Agonist Prevents Doxorubicin Cardiotoxicity.

JACC Basic Transl Sci 2017 Feb;2(1):39-53

University of North Carolina School of Medicine, McAllister Heart Institute; UNC School of Medicine, Division of Cardiology.

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http://dx.doi.org/10.1016/j.jacbts.2016.10.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5343290PMC
February 2017

BRG1 and BRM SWI/SNF ATPases redundantly maintain cardiomyocyte homeostasis by regulating cardiomyocyte mitophagy and mitochondrial dynamics in vivo.

Cardiovasc Pathol 2016 May-Jun;25(3):258-269. Epub 2016 Mar 4.

McAllister Heart Institute, University of North Carolina, Chapel Hill, NC, USA; Department of Pathology & Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599, USA; Department of Pharmacology, University of North Carolina, Chapel Hill, NC 27599, USA. Electronic address:

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http://dx.doi.org/10.1016/j.carpath.2016.02.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4860071PMC
January 2017

Upregulation of autophagy genes and the unfolded protein response in human heart failure.

Int J Clin Exp Med 2017 30;10(1):1051-1058. Epub 2017 Jan 30.

McAllister Heart Institute, University of North Carolina, Chapel Hill, NC 27599, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5546743PMC
January 2017

The Head and the Heart: The Alzheimer's Connection.

J Am Coll Cardiol 2016 12;68(22):2408-2411

McAllister Heart Institute, University of North Carolina, Chapel Hill, North Carolina; Department of Pharmacology, University of North Carolina, Chapel Hill, North Carolina; Department of Pathology & Laboratory Medicine, University of North Carolina, Chapel Hill, North Carolina. Electronic address:

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http://dx.doi.org/10.1016/j.jacc.2016.09.934DOI Listing
December 2016

Genetics and heart failure: a concise guide for the clinician.

Curr Cardiol Rev 2015 ;11(1):10-7

UNC Division of Cardiology, 160 Dental Circle, CB 7075, Chapel Hill, NC 27599-7075, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4347203PMC
May 2015

A multicenter analysis of clinical hemolysis in patients supported with durable, long-term left ventricular assist device therapy.

J Heart Lung Transplant 2015 May 4;34(5):701-9. Epub 2014 Nov 4.

Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama.

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http://dx.doi.org/10.1016/j.healun.2014.10.002DOI Listing
May 2015

Effects of an accelerated intravenous iron regimen in hospitalized patients with advanced heart failure and iron deficiency.

Pharmacotherapy 2015 Jan 29;35(1):64-71. Epub 2014 Dec 29.

School of Pharmacy, University of Maryland, Baltimore, Maryland.

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http://dx.doi.org/10.1002/phar.1525DOI Listing
January 2015

Time and technology will tell: the pathophysiologic basis of neurohormonal modulation in heart failure.

Heart Fail Clin 2014 Oct 14;10(4):543-57. Epub 2014 Aug 14.

Division of Cardiology and McAllister Heart Institute, University of North Carolina School of Medicine, 160 Dental Circle, Chapel Hill, NC 27599-7075, USA. Electronic address:

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http://dx.doi.org/10.1016/j.hfc.2014.07.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4163201PMC
October 2014

Cardiac alpha1-adrenergic receptors: novel aspects of expression, signaling mechanisms, physiologic function, and clinical importance.

Pharmacol Rev 2014 24;66(1):308-33. Epub 2013 Dec 24.

VA Medical Center (111-C-8), 4150 Clement St., San Francisco, CA 94121. or Dr. Timothy D. O'Connell, E-mail:

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http://dx.doi.org/10.1124/pr.112.007203DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3880467PMC
June 2014

Alpha-1-adrenergic receptors in heart failure: the adaptive arm of the cardiac response to chronic catecholamine stimulation.

J Cardiovasc Pharmacol 2014 Apr;63(4):291-301

*Division of Cardiology and McAllister Heart Institute, University of North Carolina, Chapel Hill, NC; †Department of Integrative Biology and Physiology, University of Minnesota, Minneapolis, MN; and ‡Division of Cardiology, VA Medical Center, Cardiovascular Research Institute, and Department of Medicine, University of California, San Francisco, CA.

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http://dx.doi.org/10.1097/FJC.0000000000000032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3980029PMC
April 2014

A novel link between G6PD deficiency and hemolysis in patients with continuous-flow left ventricular assist devices.

J Heart Lung Transplant 2014 Jan 25;33(1):116-7. Epub 2013 Oct 25.

Division of Cardiology, University of North Carolina School of Medicine, Chapel Hill, North Carolina.

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http://dx.doi.org/10.1016/j.healun.2013.10.028DOI Listing
January 2014

Heart factory or fiction?: cardiac progenitor cells and regeneration.

Circulation 2013 Nov 18;128(20):2181-2. Epub 2013 Oct 18.

McAllister Heart Institute and Division of Cardiology, University of North Carolina School of Medicine, Chapel Hill.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.113.006262DOI Listing
November 2013

Pharmacogenomics as a risk mitigation strategy for chemotherapeutic cardiotoxicity.

Pharmacogenomics 2013 Jan;14(2):205-13

UNC School of Medicine, Division of Cardiology, 160 Dental Circle, CB 7075, Chapel Hill, NC 27599-7075, USA.

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http://dx.doi.org/10.2217/pgs.12.205DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3582022PMC
January 2013

Epidemiology, management, and outcomes of sustained ventricular arrhythmias after continuous-flow left ventricular assist device implantation.

Am Heart J 2012 Sep;164(3):373-8

University of North Carolina Center for Heart and Vascular Care, Division of Cardiology, Chapel Hill, USA.

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http://dx.doi.org/10.1016/j.ahj.2012.06.018DOI Listing
September 2012

Alpha-1-adrenergic receptors: targets for agonist drugs to treat heart failure.

J Mol Cell Cardiol 2011 Oct 28;51(4):518-28. Epub 2010 Nov 28.

Cardiology Division, VA Medical Center, San Francisco, CA, USA.

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http://dx.doi.org/10.1016/j.yjmcc.2010.11.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3085055PMC
October 2011

Edge of the world: practical considerations and a clinical perspective of next-generation sequencing for hereditary cardiac disease.

Expert Opin Med Diagn 2011 Jan 8;5(1):5-8. Epub 2010 Dec 8.

University of North Carolina, Division of Cardiology, Department of Medicine, Chapel Hill, NC 27599-7075, USA.

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http://dx.doi.org/10.1517/17530059.2010.541239DOI Listing
January 2011

Functional alpha-1B adrenergic receptors on human epicardial coronary artery endothelial cells.

Naunyn Schmiedebergs Arch Pharmacol 2010 Dec 22;382(5-6):475-82. Epub 2010 Sep 22.

Cardiology Division, VA Medical Center, University of California, San Francisco, San Francisco, CA, USA.

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http://dx.doi.org/10.1007/s00210-010-0558-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2991196PMC
December 2010

Altered microRNAs in bicuspid aortic valve: a comparison between stenotic and insufficient valves.

J Heart Valve Dis 2010 Jul;19(4):459-65

Department of Pediatrics (Cardiology), University of California, San Francisco, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4242684PMC
July 2010

Evolving molecular diagnostics for familial cardiomyopathies: at the heart of it all.

Expert Rev Mol Diagn 2010 Apr;10(3):329-51

PGxHealth Division, Clinical Data, Inc., 5 Science Park, New Haven, CT 06511, USA.

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http://dx.doi.org/10.1586/erm.10.13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5022563PMC
April 2010

Heart failure switches the RV alpha1-adrenergic inotropic response from negative to positive.

Am J Physiol Heart Circ Physiol 2010 Mar 24;298(3):H913-20. Epub 2009 Dec 24.

Veterans Affairs Medical Center and Department of Medicine, University of California, San Francisco, 94121, USA.

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http://dx.doi.org/10.1152/ajpheart.00259.2009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2838546PMC
March 2010

BIN1 localizes the L-type calcium channel to cardiac T-tubules.

PLoS Biol 2010 Feb 16;8(2):e1000312. Epub 2010 Feb 16.

Cardiovascular Research Institute, University of California San Francisco, San Francisco, California, USA.

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http://dx.doi.org/10.1371/journal.pbio.1000312DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2821894PMC
February 2010

Limited forward trafficking of connexin 43 reduces cell-cell coupling in stressed human and mouse myocardium.

J Clin Invest 2010 Jan 28;120(1):266-79. Epub 2009 Dec 28.

Cardiovascular Research Institute, Department of Medicine, University of California-San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143, USA.

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http://dx.doi.org/10.1172/JCI39740DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2798685PMC
January 2010

{alpha}1-Adrenergic receptor subtypes in nonfailing and failing human myocardium.

Circ Heart Fail 2009 Nov 6;2(6):654-63. Epub 2009 Aug 6.

Cardiology Section and Research Service, San Francisco VA Medical Center, San Francisco, Calif, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2780440PMC
http://dx.doi.org/10.1161/CIRCHEARTFAILURE.108.846212DOI Listing
November 2009

Ten commercial antibodies for alpha-1-adrenergic receptor subtypes are nonspecific.

Naunyn Schmiedebergs Arch Pharmacol 2009 Apr 7;379(4):409-12. Epub 2008 Nov 7.

Cardiology Section and Research Service, San Francisco VA Medical Center (111-C-8), 4150 Clement St., San Francisco, CA 94121, USA.

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http://link.springer.com/10.1007/s00210-008-0368-6
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http://dx.doi.org/10.1007/s00210-008-0368-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2653258PMC
April 2009