Publications by authors named "Brian A Hemmings"

100Publications

AGC kinases in cancer metastasis, immune checkpoint regulation and drug resistance.

Semin Cancer Biol 2018 02;48:iii-iv

Friedrich Miescher Institute for Biomedical Research, 4058Basel, Switzerland.

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http://dx.doi.org/10.1016/j.semcancer.2018.01.013DOI Listing
February 2018

Modulation of PI3K/PTEN Pathway Does Not Affect Catalytic Activity of PDK1 in Jurkat Cells.

Anticancer Res 2017 10;37(10):5415-5423

Metabolic Syndrome and Cell Signaling Laboratory, Department of Pharmacology and Medical Science, Institute for Cancer Research, College of Medicine, Chungnam National University, Daejeon, Republic of Korea

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http://dx.doi.org/10.21873/anticanres.11969DOI Listing
October 2017

PKB/Akt-dependent regulation of inflammation in cancer.

Semin Cancer Biol 2018 02 2;48:62-69. Epub 2017 May 2.

Department of Biomedicine, University of Basel, 4031 Basel, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.semcancer.2017.04.018DOI Listing
February 2018

AKT-ions with a TWIST between EMT and MET.

Oncotarget 2016 Sep;7(38):62767-62777

Department of Biomedicine, University Hospital Basel, Basel, Switzerland.

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http://dx.doi.org/10.18632/oncotarget.11232DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5308764PMC
September 2016

Inhibition of MNK pathways enhances cancer cell response to chemotherapy with temozolomide and targeted radionuclide therapy.

Cell Signal 2016 09 8;28(9):1412-21. Epub 2016 Jun 8.

Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland.

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http://dx.doi.org/10.1016/j.cellsig.2016.06.005DOI Listing
September 2016

Acquired Resistance to Clinical Cancer Therapy: A Twist in Physiological Signaling.

Physiol Rev 2016 07;96(3):805-29

Department of Biomedicine, University Hospital Basel, Basel, Switzerland; Department of Oncology and Hematology, Papa Giovanni XXIII Hospital, Bergamo, Italy; Department of Surgery and Translational Medicine, University of Florence, Florence, Italy; Department of Molecular Biotechnology and Health Sciences, University of Turin, Torino, Italy; Department of Pharmacology, Zhejiang University School of Medicine, Hangzhou, China; and Department of Mechanisms of Cancer, Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland.

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http://physrev.physiology.org/content/physrev/96/3/805.full.
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http://dx.doi.org/10.1152/physrev.00024.2015DOI Listing
July 2016

Integrated Akt/PKB signaling in immunomodulation and its potential role in cancer immunotherapy.

J Natl Cancer Inst 2015 Jul 11;107(7). Epub 2015 Jun 11.

Department of Mechanisms of Cancer, Friedrich Miescher Institute for Biomedical Research, 4058 Basel, Switzerland (GX, FT, BAH); Department of Biomedicine, University Hospital Basel, 4031 Basel, Switzerland (GX, AZ, AW); Unit of Clinical and Translational Research, Department of Oncology and Hematology, Papa Giovanni XXIII Hospital, 24100 Bergamo, Italy (MM); Division of Pathological Anatomy, Department of Surgery and Translational Medicine, University of Florence, 50134 Florence, Italy (DM).

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http://dx.doi.org/10.1093/jnci/djv171DOI Listing
July 2015

All Akt isoforms (Akt1, Akt2, Akt3) are involved in normal hearing, but only Akt2 and Akt3 are involved in auditory hair cell survival in the mammalian inner ear.

PLoS One 2015 26;10(3):e0121599. Epub 2015 Mar 26.

Department of Biomedicine, University Hospital Basel, Hebelstrasse 20, 4031 Basel, Switzerland; Clinic for Otolaryngology, Head and Neck Surgery, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0121599PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4374771PMC
February 2016

Akt1 signaling coordinates BMP signaling and β-catenin activity to regulate second heart field progenitor development.

Development 2015 Feb;142(4):732-42

MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing Biomedical Research Institute, Nanjing University, Nanjing 210061, China Collaborative Innovation Center for Genetics and Development, Institute of Plant Biology, School of Life Sciences, Fudan University, Shanghai 200438, China

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http://dx.doi.org/10.1242/dev.119016DOI Listing
February 2015

NDR functions as a physiological YAP1 kinase in the intestinal epithelium.

Curr Biol 2015 Feb 15;25(3):296-305. Epub 2015 Jan 15.

Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.cub.2014.11.054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4426889PMC
February 2015

PKB/Akt phosphorylation of ERRγ contributes to insulin-mediated inhibition of hepatic gluconeogenesis.

Diabetologia 2014 Dec 10;57(12):2576-85. Epub 2014 Sep 10.

National Creative Research Initiatives Center for Nuclear Receptor Signals and Hormone Research Center, School of Biological Sciences and Technology, Chonnam National University, Gwangju, 500-757, Republic of Korea.

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http://dx.doi.org/10.1007/s00125-014-3366-xDOI Listing
December 2014

Reduced hepatic lipid content in Pten-haplodeficient mice because of enhanced AKT2/PKBβ activation in skeletal muscle.

Liver Int 2015 Apr 24;35(4):1354-66. Epub 2014 Jun 24.

Department of Endocrinology, Diabetes & Clinical Nutrition, University Hospital Zurich, Zurich, Switzerland; Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland.

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http://dx.doi.org/10.1111/liv.12600DOI Listing
April 2015

Novel individual metabolic profile characterizes the protein kinase B-alpha (pkbα-/-) in vivo model.

Arch Physiol Biochem 2014 Jul 28;120(3):91-8. Epub 2014 Apr 28.

UniversitätsSpital Zürich, Abteilung für Endokrinologie , Diabetologie & Klin. Ernährung, 8091 Zürich , Switzerland .

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http://www.tandfonline.com/doi/full/10.3109/13813455.2014.91
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http://dx.doi.org/10.3109/13813455.2014.911330DOI Listing
July 2014

Multimodal imaging reveals a role for Akt1 in fetal cardiac development.

Physiol Rep 2013 Nov 7;1(6):e00143. Epub 2013 Nov 7.

Biological Regulation, Weizmann Institute of Science Rehovot, Israel.

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http://dx.doi.org/10.1002/phy2.143DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871458PMC
November 2013

Characterization of fragmented 3-phosphoinsitide-dependent protein kinase-1 (PDK1) by phosphosite-specific antibodies.

Life Sci 2013 Nov 15;93(18-19):700-6. Epub 2013 Sep 15.

Department of Pharmacology, Metabolic Diseases and Cell Signaling Laboratory, Research Institute for Medical Sciences, College of Medicine, Chungnam National University, Daejeon 301-747, South Korea.

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http://dx.doi.org/10.1016/j.lfs.2013.09.007DOI Listing
November 2013

Overcoming resistance to rapalogs in gliomas by combinatory therapies.

Biochim Biophys Acta 2013 Jul 8;1834(7):1371-80. Epub 2013 Feb 8.

Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland.

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http://dx.doi.org/10.1016/j.bbapap.2013.01.041DOI Listing
July 2013

PKB/Akt-dependent regulation of cell motility.

J Natl Cancer Inst 2013 Mar 25;105(6):393-404. Epub 2013 Jan 25.

Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH-4058, Basel, Switzerland.

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http://dx.doi.org/10.1093/jnci/djs648DOI Listing
March 2013

PKB-mediated PHF20 phosphorylation on Ser291 is required for p53 function in DNA damage.

Cell Signal 2013 Jan 11;25(1):74-84. Epub 2012 Sep 11.

Department of Pharmacology, Metabolic Diseases and Cell Signaling Laboratory, Cancer Research Institute, Research Institute for Medical Sciences, College of Medicine, Chungnam National University, Daejeon, 301-131, South Korea.

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http://dx.doi.org/10.1016/j.cellsig.2012.09.009DOI Listing
January 2013

PI3K-PKB/Akt pathway.

Cold Spring Harb Perspect Biol 2012 Sep 1;4(9):a011189. Epub 2012 Sep 1.

Friedrich Miescher Institute for Biomedical Research, Basel 4058, Switzerland.

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http://dx.doi.org/10.1101/cshperspect.a011189DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3428770PMC
September 2012

Acentrosomal spindle organization renders cancer cells dependent on the kinesin HSET.

J Cell Sci 2012 Nov 3;125(Pt 22):5391-402. Epub 2012 Sep 3.

NIBR Oncology Disease Area, Novartis Pharma AG, CH-4002 Basel, Switzerland.

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http://dx.doi.org/10.1242/jcs.107474DOI Listing
November 2012

Translation regulation as a therapeutic target in cancer.

Cancer Res 2012 Aug 31;72(16):3891-900. Epub 2012 Jul 31.

Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland.

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http://dx.doi.org/10.1158/0008-5472.CAN-12-0026DOI Listing
August 2012

Akt/PKB-mediated phosphorylation of Twist1 promotes tumor metastasis via mediating cross-talk between PI3K/Akt and TGF-β signaling axes.

Cancer Discov 2012 Mar 25;2(3):248-59. Epub 2012 Jan 25.

Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland.

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http://dx.doi.org/10.1158/2159-8290.CD-11-0270DOI Listing
March 2012

Hippo signalling in the G2/M cell cycle phase: lessons learned from the yeast MEN and SIN pathways.

Semin Cell Dev Biol 2012 Sep 15;23(7):794-802. Epub 2012 Apr 15.

UCL Cancer Institute, University College London, London, United Kingdom.

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http://dx.doi.org/10.1016/j.semcdb.2012.04.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3459816PMC
September 2012

Loss of PKBβ/Akt2 predisposes mice to ovarian cyst formation and increases the severity of polycystic ovary formation in vivo.

Dis Model Mech 2012 May 24;5(3):403-11. Epub 2012 Jan 24.

Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH-4058 Basel, Switzerland.

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http://dmm.biologists.org/cgi/doi/10.1242/dmm.008136
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http://dx.doi.org/10.1242/dmm.008136DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3339834PMC
May 2012

Phosphorylation of basic helix-loop-helix transcription factor Twist in development and disease.

Biochem Soc Trans 2012 Feb;40(1):90-3

Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH-4058 Basel, Switzerland.

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http://dx.doi.org/10.1042/BST20110678DOI Listing
February 2012

PI3K/AKT, MAPK and AMPK signalling: protein kinases in glucose homeostasis.

Expert Rev Mol Med 2012 Jan 11;14:e1. Epub 2012 Jan 11.

Division of Endocrinology, Diabetes and Clinical Nutrition, University Hospital of Zurich, Zurich, Switzerland.

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http://www.journals.cambridge.org/abstract_S1462399411002109
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http://dx.doi.org/10.1017/S1462399411002109DOI Listing
January 2012

The Akt1 isoform is an essential mediator of ischaemic preconditioning.

J Cell Mol Med 2012 Aug;16(8):1739-49

The Hatter Cardiovascular Institute, The Institute of Cardiovascular Science, University College London, London, UK.

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http://dx.doi.org/10.1111/j.1582-4934.2011.01491.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3822687PMC
August 2012

S6K inhibition renders cardiac protection against myocardial infarction through PDK1 phosphorylation of Akt.

Biochem J 2012 Jan;441(1):199-207

MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing University, Nanjing, China.

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http://dx.doi.org/10.1042/BJ20110033DOI Listing
January 2012

Downstream of human NDR kinases: impacting on c-myc and p21 protein stability to control cell cycle progression.

Cell Cycle 2011 Jun 15;10(12):1897-904. Epub 2011 Jun 15.

Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland.

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http://dx.doi.org/10.4161/cc.10.12.15826DOI Listing
June 2011

Phosphorylation of the Twist1-family basic helix-loop-helix transcription factors is involved in pathological cardiac remodeling.

PLoS One 2011 Apr 29;6(4):e19251. Epub 2011 Apr 29.

The Ministry of Education Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing University, Nanjing, China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0019251PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084786PMC
April 2011

Human NDR kinases control G(1)/S cell cycle transition by directly regulating p21 stability.

Mol Cell Biol 2011 Apr 24;31(7):1382-95. Epub 2011 Jan 24.

Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH-4058 Basel, Switzerland.

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http://dx.doi.org/10.1128/MCB.01216-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3135299PMC
April 2011

Promiscuous affairs of PKB/AKT isoforms in metabolism.

Arch Physiol Biochem 2011 May 10;117(2):70-7. Epub 2011 Jan 10.

Endocrinology, Diabetology & Clinical Nutrition, University Hospital of Zurich, Switzerland.

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http://dx.doi.org/10.3109/13813455.2010.539236DOI Listing
May 2011

From man to mouse and back again: advances in defining tumor AKTivities in vivo.

Dis Model Mech 2010 Nov-Dec;3(11-12):705-20. Epub 2010 Oct 12.

Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH-4058 Basel, Switzerland.

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http://dx.doi.org/10.1242/dmm.004671DOI Listing
February 2011

Deletion of Akt1 causes heart defects and abnormal cardiomyocyte proliferation.

Dev Biol 2010 Nov 15;347(2):384-91. Epub 2010 Sep 15.

MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center of Nanjing University, Nanjing, China.

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https://linkinghub.elsevier.com/retrieve/pii/S00121606100104
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http://dx.doi.org/10.1016/j.ydbio.2010.08.033DOI Listing
November 2010

Akt/Protein kinase B is required for lymphatic network formation, remodeling, and valve development.

Am J Pathol 2010 Oct 19;177(4):2124-33. Epub 2010 Aug 19.

Laboratory of Vascular and Cancer Biology, MOE Key Laboratory for Model Animal and Disease Study, Model Animal Research Institute, Nanjing University, Nanjing, China.

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http://dx.doi.org/10.2353/ajpath.2010.091301DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2947305PMC
October 2010

Phosphatidylinositol 3-kinase signaling in thymocytes: the need for stringent control.

Sci Signal 2010 Aug 17;3(135):re5. Epub 2010 Aug 17.

Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland.

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http://dx.doi.org/10.1126/scisignal.3135re5DOI Listing
August 2010

Differential NDR/LATS interactions with the human MOB family reveal a negative role for human MOB2 in the regulation of human NDR kinases.

Mol Cell Biol 2010 Sep 12;30(18):4507-20. Epub 2010 Jul 12.

Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH-4058 Basel, Switzerland.

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http://dx.doi.org/10.1128/MCB.00150-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2937529PMC
September 2010

Ablation of the kinase NDR1 predisposes mice to the development of T cell lymphoma.

Sci Signal 2010 Jun 15;3(126):ra47. Epub 2010 Jun 15.

Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH-4058 Basel, Switzerland.

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http://dx.doi.org/10.1126/scisignal.2000681DOI Listing
June 2010

Protein kinase B (PKB/Akt), a key mediator of the PI3K signaling pathway.

Curr Top Microbiol Immunol 2010 ;346:31-56

Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058, Basel, Switzerland.

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http://link.springer.com/10.1007/82_2010_58
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http://dx.doi.org/10.1007/82_2010_58DOI Listing
January 2011

TAZ-mediated crosstalk between Wnt and Hippo signaling.

Dev Cell 2010 Apr;18(4):508-9

Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH-4058 Basel, Switzerland.

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http://dx.doi.org/10.1016/j.devcel.2010.04.003DOI Listing
April 2010

Deregulated signalling networks in human brain tumours.

Biochim Biophys Acta 2010 Mar 29;1804(3):476-83. Epub 2009 Oct 29.

Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH-4058 Basel, Switzerland.

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http://dx.doi.org/10.1016/j.bbapap.2009.10.018DOI Listing
March 2010

Cell signaling. Blocking Akt-ivity.

Science 2009 Aug;325(5944):1083-4

Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH-4058 Basel, Switzerland.

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http://www.sciencemag.org/cgi/doi/10.1126/science.1179972
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http://dx.doi.org/10.1126/science.1179972DOI Listing
August 2009

Heat shock protein 70-mediated sensitization of cells to apoptosis by Carboxyl-Terminal Modulator Protein.

BMC Cell Biol 2009 Jul 15;10:53. Epub 2009 Jul 15.

Department of Pharmacology, Daejeon Regional Cancer Center, Cancer Research Institute, Research Institute for Medical Sciences, College of Medicine, Chungnam National University, Taejeon, 301-131, Korea.

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http://dx.doi.org/10.1186/1471-2121-10-53DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2729731PMC
July 2009

Mammalian NDR/LATS protein kinases in hippo tumor suppressor signaling.

Biofactors 2009 Jul-Aug;35(4):338-45

Friedrich Miescher Institute for Biomedical Research, Growth Control, Maulbeerstrasse 66, Basel, Switzerland.

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http://doi.wiley.com/10.1002/biof.47
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http://dx.doi.org/10.1002/biof.47DOI Listing
November 2009

The endogenous inhibitor of Akt, CTMP, is critical to ischemia-induced neuronal death.

Nat Neurosci 2009 May 6;12(5):618-26. Epub 2009 Apr 6.

Dominick P. Purpura Department of Neuroscience, Rose F. Kennedy Center, Albert Einstein College of Medicine, Bronx, New York, USA.

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http://www.nature.com/articles/nn.2299
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http://dx.doi.org/10.1038/nn.2299DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2724841PMC
May 2009

Targeting the Kinome II.

Curr Opin Cell Biol 2009 Apr 1;21(2):135-9. Epub 2009 Apr 1.

Friedrich Miescher Institute, Basel, Switzerland.

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http://linkinghub.elsevier.com/retrieve/pii/S095506740900063
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http://dx.doi.org/10.1016/j.ceb.2009.03.001DOI Listing
April 2009

Association of LETM1 and MRPL36 contributes to the regulation of mitochondrial ATP production and necrotic cell death.

Cancer Res 2009 Apr 24;69(8):3397-404. Epub 2009 Mar 24.

Department of Pharmacology, Daejeon Regional Cancer Center, Cancer Research Institute, Research Institute for Medical Sciences, South Korea.

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http://dx.doi.org/10.1158/0008-5472.CAN-08-3235DOI Listing
April 2009

PIKKing on PKB: regulation of PKB activity by phosphorylation.

Curr Opin Cell Biol 2009 Apr 19;21(2):256-61. Epub 2009 Mar 19.

Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland.

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http://dx.doi.org/10.1016/j.ceb.2009.02.002DOI Listing
April 2009

Carboxy-Terminal Modulator Protein (CTMP) is a mitochondrial protein that sensitizes cells to apoptosis.

Cell Signal 2009 Apr 8;21(4):639-50. Epub 2009 Jan 8.

Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, Switzerland.

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http://linkinghub.elsevier.com/retrieve/pii/S089865680900005
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http://dx.doi.org/10.1016/j.cellsig.2009.01.016DOI Listing
April 2009

Regulation of OPA1-mediated mitochondrial fusion by leucine zipper/EF-hand-containing transmembrane protein-1 plays a role in apoptosis.

Cell Signal 2009 May 9;21(5):767-77. Epub 2009 Jan 9.

Department of Pharmacology, Daejeon Regional Cancer Center, Cancer Research Institute, Research Institute for Medical Sciences, College of Medicine, Chungnam National University, Taejeon, 301-131, Republic of Korea.

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http://dx.doi.org/10.1016/j.cellsig.2009.01.020DOI Listing
May 2009

DNA-dependent protein kinase-mediated phosphorylation of protein kinase B requires a specific recognition sequence in the C-terminal hydrophobic motif.

J Biol Chem 2009 Mar 14;284(10):6169-74. Epub 2009 Jan 14.

Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, Basel CH-4058, Switzerland.

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http://www.jbc.org/lookup/doi/10.1074/jbc.C800210200
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http://dx.doi.org/10.1074/jbc.C800210200DOI Listing
March 2009

NDR kinase is activated by RASSF1A/MST1 in response to Fas receptor stimulation and promotes apoptosis.

Curr Biol 2008 Dec;18(23):1889-95

Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH-4058 Basel, Switzerland.

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http://dx.doi.org/10.1016/j.cub.2008.10.060DOI Listing
December 2008

In vivo analysis of protein kinase B (PKB)/Akt regulation in DNA-PKcs-null mice reveals a role for PKB/Akt in DNA damage response and tumorigenesis.

J Biol Chem 2008 Oct 29;283(44):30025-33. Epub 2008 Aug 29.

Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, Basel CH 4058, Switzerland.

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http://dx.doi.org/10.1074/jbc.M803053200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2662067PMC
October 2008

Evidence of placental translation inhibition and endoplasmic reticulum stress in the etiology of human intrauterine growth restriction.

Am J Pathol 2008 Aug 26;173(2):451-62. Epub 2008 Jun 26.

Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge CB2 3EG, UK.

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http://dx.doi.org/10.2353/ajpath.2008.071193DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2475782PMC
August 2008

Nuclear Dbf2-related protein kinases (NDRs) in isolated cardiac myocytes and the myocardium: activation by cellular stresses and by phosphoprotein serine-/threonine-phosphatase inhibitors.

Cell Signal 2008 Aug 1;20(8):1564-77. Epub 2008 May 1.

National Heart and Lung Institute (NHLI) Division, Faculty of Medicine, Imperial College London, Flowers Building, Armstrong Road, London SW7 2AZ, UK.

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http://dx.doi.org/10.1016/j.cellsig.2008.04.013DOI Listing
August 2008

PKBalpha/Akt1 acts downstream of DNA-PK in the DNA double-strand break response and promotes survival.

Mol Cell 2008 Apr;30(2):203-13

Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, Switzerland.

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http://dx.doi.org/10.1016/j.molcel.2008.02.024DOI Listing
April 2008

Regulation of 3-phosphoinositide-dependent protein kinase-1 (PDK1) by Src involves tyrosine phosphorylation of PDK1 and Src homology 2 domain binding.

J Biol Chem 2008 Jan 16;283(3):1480-91. Epub 2007 Nov 16.

Department of Pharmacology, Daejeon Regional Cancer Center, Cancer Research Institute, Chungnam National University, 6 Munhwa-Dong, Jung-Gu, Taejeon 301-131, South Korea.

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http://dx.doi.org/10.1074/jbc.M706361200DOI Listing
January 2008

Deletion of PKBalpha/Akt1 affects thymic development.

PLoS One 2007 Oct 3;2(10):e992. Epub 2007 Oct 3.

Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0000992PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1991598PMC
October 2007

Mammalian NDR protein kinases: from regulation to a role in centrosome duplication.

Biochim Biophys Acta 2008 Jan 15;1784(1):3-15. Epub 2007 Aug 15.

Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH-4058, Basel, Switzerland.

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http://linkinghub.elsevier.com/retrieve/pii/S157096390700179
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http://dx.doi.org/10.1016/j.bbapap.2007.07.017DOI Listing
January 2008

PKB and the mitochondria: AKTing on apoptosis.

Cell Signal 2008 Jan 25;20(1):21-30. Epub 2007 Jul 25.

Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, Switzerland.

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http://dx.doi.org/10.1016/j.cellsig.2007.07.010DOI Listing
January 2008

Meeting report: targeting the kinome--20 years of tyrosine kinase inhibitor research in Basel.

Sci STKE 2007 Feb 20;2007(374):pe8. Epub 2007 Feb 20.

Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland.

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http://dx.doi.org/10.1126/stke.3742007pe8DOI Listing
February 2007

Centrosome-associated NDR kinase regulates centrosome duplication.

Mol Cell 2007 Feb;25(4):625-34

Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH-4058 Basel, Switzerland.

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http://dx.doi.org/10.1016/j.molcel.2007.01.020DOI Listing
February 2007

Altered levels of PP2A regulatory B/PR55 isoforms indicate role in neuronal differentiation.

Int J Dev Neurosci 2006 Nov 11;24(7):437-43. Epub 2006 Oct 11.

Division of Psychiatry Research, University of Zurich, August Forel Strasse 1, 8008 Zurich, Switzerland.

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http://dx.doi.org/10.1016/j.ijdevneu.2006.08.005DOI Listing
November 2006

Only Akt1 is required for proliferation, while Akt2 promotes cell cycle exit through p21 binding.

Mol Cell Biol 2006 Nov 18;26(22):8267-80. Epub 2006 Sep 18.

Cell Biology Unit, Institut de Génétique Humaine, CNRS UPR1142, 141 rue de la Cardonille, 34396 Montpellier Cedex 5, France.

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http://dx.doi.org/10.1128/MCB.00201-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1636765PMC
November 2006

Interaction of nucleoredoxin with protein phosphatase 2A.

FEBS Lett 2006 Jun 2;580(15):3631-7. Epub 2006 Jun 2.

Cell and Molecular Signalling Laboratory, Intercollegiate Faculty of Biotechnology UG-MUG, Gdansk, Poland.

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http://dx.doi.org/10.1016/j.febslet.2006.04.101DOI Listing
June 2006

The human tumour suppressor LATS1 is activated by human MOB1 at the membrane.

Biochem Biophys Res Commun 2006 Jun 25;345(1):50-8. Epub 2006 Apr 25.

Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH-4058 Basel, Switzerland.

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http://linkinghub.elsevier.com/retrieve/pii/S0006291X0600793
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http://dx.doi.org/10.1016/j.bbrc.2006.03.244DOI Listing
June 2006

NDR kinases regulate essential cell processes from yeast to humans.

Nat Rev Mol Cell Biol 2006 Apr;7(4):253-64

Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH-4058 Basel, Switzerland.

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http://dx.doi.org/10.1038/nrm1891DOI Listing
April 2006

PKBalpha is required for adipose differentiation of mouse embryonic fibroblasts.

J Cell Sci 2006 Mar 14;119(Pt 5):889-97. Epub 2006 Feb 14.

Friedrich Miescher Institute for Biomedical Research, Maulbeerstr. 66, CH-4058, Basel, Switzerland.

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http://jcs.biologists.org/cgi/doi/10.1242/jcs.02792
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http://dx.doi.org/10.1242/jcs.02792DOI Listing
March 2006

Protein kinase B/Akt at a glance.

J Cell Sci 2005 Dec;118(Pt 24):5675-8

Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, Switzerland.

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http://dx.doi.org/10.1242/jcs.02724DOI Listing
December 2005

PI3K rescues the detrimental effects of chronic Akt activation in the heart during ischemia/reperfusion injury.

J Clin Invest 2005 Aug 7;115(8):2128-38. Epub 2005 Jul 7.

Program in Cardiovascular Gene Therapy, Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1172/JCI23073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1172227PMC
August 2005

PromoterPlot: a graphical display of promoter similarities by pattern recognition.

Nucleic Acids Res 2005 Jul;33(Web Server issue):W423-6

Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH-4058 Basel, Switzerland.

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http://dx.doi.org/10.1093/nar/gki413DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1160174PMC
July 2005

Essential role of protein kinase B gamma (PKB gamma/Akt3) in postnatal brain development but not in glucose homeostasis.

Development 2005 Jul 1;132(13):2943-54. Epub 2005 Jun 1.

Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH-4058 Basel, Switzerland.

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http://dx.doi.org/10.1242/dev.01864DOI Listing
July 2005