Brett A Wagner

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Brett A Wagner

Publications by authors named "Brett A Wagner"

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46Publications

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Corrigendum to: Augmentation of intracellular iron using iron sucrose enhances the toxicity of pharmacological ascorbate in colon cancer cells [Redox Biol. (2018) 82-87].

Redox Biol 2018 Jun 8. Epub 2018 Jun 8.

Free Radical and Radiation Biology Program, Departments of Radiation Oncology, Carver College of Medicine, Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, IA 52242, United States. Electronic address:

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June 2018

Augmentation of intracellular iron using iron sucrose enhances the toxicity of pharmacological ascorbate in colon cancer cells.

Redox Biol 2018 Apr 26;14:82-87. Epub 2017 Aug 26.

Free Radical and Radiation Biology Program, Departments of Radiation Oncology, Carver College of Medicine, Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, IA 52242, United States. Electronic address:

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April 2018

Redox active metals and HO mediate the increased efficacy of pharmacological ascorbate in combination with gemcitabine or radiation in pre-clinical sarcoma models.

Redox Biol 2018 Apr 28;14:417-422. Epub 2017 Sep 28.

Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, IA 52242, United States. Electronic address:

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April 2018

Superoxide Dismutase Mimetic GC4419 Enhances the Oxidation of Pharmacological Ascorbate and Its Anticancer Effects in an H₂O₂-Dependent Manner.

Antioxidants (Basel) 2018 Jan 19;7(1). Epub 2018 Jan 19.

Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, The University of Iowa College of Medicine, Iowa City, IA 52242, USA.

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January 2018

Mitofusin 1 and optic atrophy 1 shift metabolism to mitochondrial respiration during aging.

Aging Cell 2017 Oct 31;16(5):1136-1145. Epub 2017 Jul 31.

Free Radical and Radiation Biology Division, Department of Radiation Oncology, University of Iowa, Iowa City, IA, USA.

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October 2017

Tumor cells have decreased ability to metabolize HO: Implications for pharmacological ascorbate in cancer therapy.

Redox Biol 2016 12 28;10:274-284. Epub 2016 Oct 28.

Interdisciplinary Graduate Program in Human Toxicology, The University of Iowa, Iowa City, IA 52242, USA; Free Radical & Radiation Biology Program in the Department of Radiation Oncology, The University of Iowa, Iowa City, IA 52242, USA. Electronic address:

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December 2016

Direct spectrophotometric measurement of supra-physiological levels of ascorbate in plasma.

Redox Biol 2016 08 13;8:298-304. Epub 2016 Feb 13.

Department of Radiation Oncology, Free Radical and Radiation Biology Program, B180 Medical Laboratories, The University of Iowa, Iowa City, IA 52242-1181, United States. Electronic address:

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August 2016

Moles of a Substance per Cell Is a Highly Informative Dosing Metric in Cell Culture.

PLoS One 2015 14;10(7):e0132572. Epub 2015 Jul 14.

Interdisciplinary Graduate Program in Human Toxicology, The University of Iowa, Iowa City, Iowa, 52242, United States of America; Free Radical and Radiation Biology Program, Department of Radiation Oncology, The University of Iowa, Iowa City, Iowa, 52242, United States of America.

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May 2016

Succinate dehydrogenase activity regulates PCB3-quinone-induced metabolic oxidative stress and toxicity in HaCaT human keratinocytes.

Arch Toxicol 2016 Feb 23;90(2):319-32. Epub 2014 Nov 23.

Free Radical and Radiation Biology Division, Department of Radiation Oncology, B180 Medical Laboratories, The University of Iowa, Iowa City, IA, 52242, USA.

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February 2016

Pharmacological Ascorbate Radiosensitizes Pancreatic Cancer.

Cancer Res 2015 Aug 16;75(16):3314-26. Epub 2015 Jun 16.

Department of Surgery, University of Iowa College of Medicine, Iowa City, Iowa. Department of Radiation Oncology, University of Iowa College of Medicine, Iowa City, Iowa. Holden Comprehensive Cancer Center, Iowa City, Iowa. Veterans Affairs Medical Center, Iowa City, Iowa.

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August 2015

Role of labile iron in the toxicity of pharmacological ascorbate.

Free Radic Biol Med 2015 Jul 7;84:289-295. Epub 2015 Apr 7.

Department of Surgery, University of Iowa College of Medicine, Iowa City, IA 52242, USA; Department of Radiation Oncology, Free Radical and Radiation Biology Program, University of Iowa College of Medicine, Iowa City, IA 52242, USA; Holden Comprehensive Cancer Center, Iowa City, IA, USA; Veterans Affairs Medical Center, Iowa City, IA, USA. Electronic address:

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July 2015

Manganoporphyrins and ascorbate enhance gemcitabine cytotoxicity in pancreatic cancer.

Free Radic Biol Med 2015 Jun 26;83:227-37. Epub 2015 Feb 26.

Department of Surgery, University of Iowa College of Medicine, Iowa City, IA 52242, USA; Holden Comprehensive Cancer Center, Iowa City, IA 52242, USA; Veterans Affairs Medical Center, Iowa City, IA 52242, USA. Electronic address:

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June 2015

Pharmacological ascorbate and ionizing radiation (IR) increase labile iron in pancreatic cancer.

Redox Biol 2013 26;2:22-7. Epub 2013 Nov 26.

Free Radical and Radiation Biology Program and ESR Facility, Department of Radiation Oncology, The University of Iowa, Iowa City, IA, USA ; Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, IA, USA.

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March 2015

Heritability of glutathione and related metabolites in stored red blood cells.

Free Radic Biol Med 2014 Nov 7;76:107-13. Epub 2014 Aug 7.

Free Radical and Radiation Biology Program, Radiation Oncology, The University of Iowa, Iowa City, IA 52242, USA; Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, IA 52242, USA. Electronic address:

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November 2014

SIRT3 deacetylates and increases pyruvate dehydrogenase activity in cancer cells.

Free Radic Biol Med 2014 Nov 22;76:163-172. Epub 2014 Aug 22.

Department of Radiation Oncology, Robert Lurie Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL 60611.

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November 2014

The concentration of glutathione in human erythrocytes is a heritable trait.

Free Radic Biol Med 2013 Dec 9;65:742-9. Epub 2013 Aug 9.

Interdisciplinary Program in Human Toxicology, The University of Iowa, Iowa City, IA 52242, USA.

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December 2013

Quantitative redox biology: an approach to understand the role of reactive species in defining the cellular redox environment.

Cell Biochem Biophys 2013 Nov;67(2):477-83

Free Radical and Radiation Biology & ESR Facility, Med Labs B180, The University of Iowa, Iowa City, IA, 52242-1181, USA,

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November 2013

Manganoporphyrins increase ascorbate-induced cytotoxicity by enhancing H2O2 generation.

Cancer Res 2013 Aug 13;73(16):5232-41. Epub 2013 Jun 13.

Department of Radiation Oncology, The University of Iowa Carver College of Medicine, Iowa City, IA, USA.

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August 2013

Regulation of pancreatic cancer growth by superoxide.

Mol Carcinog 2013 Jul 5;52(7):555-67. Epub 2012 Mar 5.

Departments of Radiation Oncology, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA.

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July 2013

An Assay for the Rate of Removal of Extracellular Hydrogen Peroxide by Cells.

Redox Biol 2013 ;1(1):210-217

The University of Iowa, Free Radical and Radiation Biology Program & ESR Facility, Iowa City, IA 52242-1181, USA.

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January 2013

Interleukin-6 counteracts therapy-induced cellular oxidative stress in multiple myeloma by up-regulating manganese superoxide dismutase.

Biochem J 2012 Jun;444(3):515-27

Free Radical and Radiation Biology Program, Department of Radiation Oncology, University of Iowa, Iowa City, IA 52242, USA.

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June 2012

Heme oxygenase-1 is protective against nonsteroidal anti-inflammatory drug-induced gastric ulcers.

J Pediatr Gastroenterol Nutr 2012 Apr;54(4):471-6

Department of Pediatrics, University of Iowa Carver College of Medicine,200 Hawkins Dr, Iowa City, IA 52242, USA.

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April 2012

The rate of oxygen utilization by cells.

Free Radic Biol Med 2011 Aug 27;51(3):700-12. Epub 2011 May 27.

Free Radical and Radiation Biology Program and ESR Facility, The University of Iowa, Iowa City, IA 52242–1181, USA.

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August 2011

Free radicals produced by the oxidation of gallic acid: An electron paramagnetic resonance study.

Chem Cent J 2010 Aug 5;4:15. Epub 2010 Aug 5.

Free Radical and Radiation Biology, Med Labs B180, The University of Iowa, Iowa City, IA 52242-1181, USA.

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August 2010

Mechanisms of ascorbate-induced cytotoxicity in pancreatic cancer.

Clin Cancer Res 2010 Jan 12;16(2):509-20. Epub 2010 Jan 12.

Department of Surgery, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA.

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January 2010

Nonenzymatic displacement of chlorine and formation of free radicals upon the reaction of glutathione with PCB quinones.

Proc Natl Acad Sci U S A 2009 Jun 2;106(24):9725-30. Epub 2009 Jun 2.

Department of Occupational and Environmental Health, University of Iowa, 100 Oakdale Campus, 124 IREH, Iowa City, IA 52242-5000, USA.

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June 2009

Chlorination increases the persistence of semiquinone free radicals derived from polychlorinated biphenyl hydroquinones and quinones.

J Org Chem 2008 Nov 8;73(21):8296-304. Epub 2008 Oct 8.

Department of Occupational and Environmental Health, The University of Iowa, 100 Oakdale Campus, 124 IREH, Iowa City, Iowa 52242-5000, USA.

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November 2008

Semiquinone radicals from oxygenated polychlorinated biphenyls: electron paramagnetic resonance studies.

Chem Res Toxicol 2008 Jul 13;21(7):1359-67. Epub 2008 Jun 13.

Department of Occupational and Environmental Health, The University of Iowa, Iowa City, Iowa 52242-1101, USA.

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July 2008

Inactivation of anthracyclines by serum heme proteins.

Chem Res Toxicol 2007 Jun 12;20(6):920-6. Epub 2007 May 12.

Department of Internal Medicine, University of Iowa, USA.

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June 2007

Doxorubicin increases intracellular hydrogen peroxide in PC3 prostate cancer cells.

Arch Biochem Biophys 2005 Aug;440(2):181-90

Department of Medicine, The University of Iowa Carver College of Medicine and Holden Comprehensive Cancer Center, Iowa City, IA 52242, USA.

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August 2005

Inactivation of anthracyclines by cellular peroxidase.

Cancer Res 2005 Jul;65(14):6346-53

Research Service and Department of Internal Medicine, The Veterans Affairs Medical Center, USA.

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July 2005

Overexpression of manganese superoxide dismutase promotes the survival of prostate cancer cells exposed to hyperthermia.

Free Radic Res 2004 Oct;38(10):1119-32

Department of Radiation Oncology, Free Radical and Radiation Biology Program, EMRB 68, The University of Iowa, Iowa City, IA 52242-1101, USA.

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October 2004

Acetaminophen stimulates the peroxidative metabolism of anthracyclines.

Arch Biochem Biophys 2004 Jul;427(1):16-29

Research Service, VA Medical Center, Iowa City, IA 52246, USA.

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July 2004

Phase II study of high-dose fish oil capsules for patients with cancer-related cachexia.

Cancer 2004 Jul;101(2):370-8

Department of Internal Medicine, The University of Iowa Roy J. and Lucille A. Carver College of Medicine, Iowa City, Iowa 52242, USA.

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July 2004

Role of thiocyanate, bromide and hypobromous acid in hydrogen peroxide-induced apoptosis.

Free Radic Res 2004 Feb;38(2):167-75

Department of Medicine, Free Radical and Radiation Biology Graduate Program, University of Iowa Roy J. and Lucille A. Carver College of Medicine, Iowa City, IA 52242, USA.

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February 2004

Lactoferrin in the preterm infants' diet attenuates iron-induced oxidation products.

Pediatr Res 2002 Dec;52(6):964-72

Department of Pediatrics, The University of Iowa, Iowa City, Iowa 52242, USA.

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December 2002

Role of nitric oxide and membrane phospholipid polyunsaturation in oxidative cell death.

Subcell Biochem 2002 ;36:97-121

Department of Medicine, University of Iowa College of Medicine, Iowa City, IA, USA.

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July 2002

Hydrogen peroxide-induced apoptosis of HL-60 human leukemia cells is mediated by the oxidants hypochlorous acid and chloramines.

Arch Biochem Biophys 2002 May;401(2):223-34

Department of Medicine and Radiation Oncology (Free Radical and Radiation Biology Graduate Program), The University of Iowa College of Medicine, Iowa City, IA 52242, USA.

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May 2002