Publications

Augmentation of intracellular iron using iron sucrose enhances the toxicity of pharmacological ascorbate in colon cancer cells.
Redox Biol 2018 Apr 26;14:82-87. Epub 2017 Aug 26.
Free Radical and Radiation Biology Program, Departments of Radiation Oncology, Carver College of Medicine, Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, IA 52242, United States. Electronic address:

Redox active metals and HOmediate the increased efficacy of pharmacological ascorbate in combination with gemcitabine or radiation in pre-clinical sarcoma models.
Redox Biol 2018 Apr 28;14:417-422. Epub 2017 Sep 28.
Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, IA 52242, United States. Electronic address:

Superoxide Dismutase Mimetic GC4419 Enhances the Oxidation of Pharmacological Ascorbate and Its Anticancer Effects in an H₂O₂-Dependent Manner.
Antioxidants (Basel) 2018 Jan 19;7(1). Epub 2018 Jan 19.
Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, The University of Iowa College of Medicine, Iowa City, IA 52242, USA.


Succinate dehydrogenase activity regulates PCB3-quinone-induced metabolic oxidative stress and toxicity in HaCaT human keratinocytes.
Arch Toxicol 2016 Feb 23;90(2):319-32. Epub 2014 Nov 23.
Free Radical and Radiation Biology Division, Department of Radiation Oncology, B180 Medical Laboratories, The University of Iowa, Iowa City, IA, 52242, USA.

Pharmacological Ascorbate Radiosensitizes Pancreatic Cancer.
Cancer Res 2015 Aug 16;75(16):3314-26. Epub 2015 Jun 16.
Department of Surgery, University of Iowa College of Medicine, Iowa City, Iowa. Department of Radiation Oncology, University of Iowa College of Medicine, Iowa City, Iowa. Holden Comprehensive Cancer Center, Iowa City, Iowa. Veterans Affairs Medical Center, Iowa City, Iowa.

Role of labile iron in the toxicity of pharmacological ascorbate.
Free Radic Biol Med 2015 Jul 7;84:289-295. Epub 2015 Apr 7.
Department of Surgery, University of Iowa College of Medicine, Iowa City, IA 52242, USA; Department of Radiation Oncology, Free Radical and Radiation Biology Program, University of Iowa College of Medicine, Iowa City, IA 52242, USA; Holden Comprehensive Cancer Center, Iowa City, IA, USA; Veterans Affairs Medical Center, Iowa City, IA, USA. Electronic address:


Manganoporphyrins and ascorbate enhance gemcitabine cytotoxicity in pancreatic cancer.
Free Radic Biol Med 2015 Jun 26;83:227-37. Epub 2015 Feb 26.
Department of Surgery, University of Iowa College of Medicine, Iowa City, IA 52242, USA; Holden Comprehensive Cancer Center, Iowa City, IA 52242, USA; Veterans Affairs Medical Center, Iowa City, IA 52242, USA. Electronic address:


Heritability of glutathione and related metabolites in stored red blood cells.
Free Radic Biol Med 2014 Nov 7;76:107-13. Epub 2014 Aug 7.
Free Radical and Radiation Biology Program, Radiation Oncology, The University of Iowa, Iowa City, IA 52242, USA; Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, IA 52242, USA. Electronic address:


Moles of a Substance per Cell Is a Highly Informative Dosing Metric in Cell Culture.
PLoS One 2015 14;10(7):e0132572. Epub 2015 Jul 14.
Interdisciplinary Graduate Program in Human Toxicology, The University of Iowa, Iowa City, Iowa, 52242, United States of America; Free Radical and Radiation Biology Program, Department of Radiation Oncology, The University of Iowa, Iowa City, Iowa, 52242, United States of America.

Tumor cells have decreased ability to metabolize HO: Implications for pharmacological ascorbate in cancer therapy.
Redox Biol 2016 12 28;10:274-284. Epub 2016 Oct 28.
Interdisciplinary Graduate Program in Human Toxicology, The University of Iowa, Iowa City, IA 52242, USA; Free Radical & Radiation Biology Program in the Department of Radiation Oncology, The University of Iowa, Iowa City, IA 52242, USA. Electronic address:


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