Brendon P Scicluna

Brendon P Scicluna

UNVERIFIED PROFILE

Are you Brendon P Scicluna?   Register this Author

Register author
Brendon P Scicluna

Brendon P Scicluna

Publications by authors named "Brendon P Scicluna"

Are you Brendon P Scicluna?   Register this Author

60Publications

1571Reads

25Profile Views

Leukocyte transcriptional signatures dependent on LPS dosage in human endotoxemia.

J Leukoc Biol 2019 Nov 7;106(5):1153-1160. Epub 2019 Jul 7.

Center for Experimental Molecular Medicine, Amsterdam University Medical Centers, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/JLB.4A0219-050RDOI Listing
November 2019

Prekallikrein inhibits innate immune signaling in the lung and impairs host defense during pneumosepsis in mice.

J Pathol 2019 Oct 9. Epub 2019 Oct 9.

Center of Experimental & Molecular Medicine, Amsterdam University Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/path.5354DOI Listing
October 2019

Genetic signature related to heme-hemoglobin metabolism pathway in sepsis secondary to pneumonia.

NPJ Syst Biol Appl 2019 1;5:26. Epub 2019 Aug 1.

1Division of Infectious Diseases, Department of Medicine, Hospital São Paulo, Escola Paulista de Medicina, Universidade Federal de Sao Paulo, São Paulo, Brazil.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41540-019-0105-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6672010PMC
August 2019

Understanding Heterogeneity in Biologic Phenotypes of Acute Respiratory Distress Syndrome by Leukocyte Expression Profiles.

Am J Respir Crit Care Med 2019 Jul;200(1):42-50

1 Intensive Care, Laboratory of Experimental Intensive Care and Anesthesiology.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1164/rccm.201809-1808OCDOI Listing
July 2019

Matrix metalloproteinase-8: a useful biomarker to refine the diagnosis of community-acquired pneumonia upon intensive care unit admission?

Crit Care 2019 06 20;23(1):226. Epub 2019 Jun 20.

Center of Infection and Immunity Amsterdam (CINIMA), Amsterdam University Medical Centers, location Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13054-019-2513-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6585071PMC
June 2019

The Search for Efficacious New Therapies in Sepsis Needs to Embrace Heterogeneity.

Am J Respir Crit Care Med 2019 Apr;199(8):936-938

2 Roslin Institute University of Edinburgh Edinburgh, United Kingdom and.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1164/rccm.201811-2148EDDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467300PMC
April 2019

The Itaconate Pathway Is a Central Regulatory Node Linking Innate Immune Tolerance and Trained Immunity.

Cell Metab 2019 01 4;29(1):211-220.e5. Epub 2018 Oct 4.

Department of Internal Medicine (463) and Radboud Center for Infectious Diseases (RCI), Radboud University Nijmegen Medical Centre, Geert Grooteplein 8, Nijmegen 6500 HB, the Netherlands; Department for Genomics & Immunoregulation, Life and Medical Sciences Institute (LIMES), University of Bonn, Bonn, Germany; Human Genomics Laboratory, Craiova University of Medicine and Pharmacy, Craiova, Romania.

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S15504131183056
Publisher Site
http://dx.doi.org/10.1016/j.cmet.2018.09.003DOI Listing
January 2019

Classification of patients with septic shock: Are we there yet?

J Crit Care 2018 10 27;47:320-321. Epub 2018 Jul 27.

Amsterdam UMC, Univ of Amsterdam, Center for Experimental Molecular Medicine, Amsterdam Infection & Immunity,Meibergdreef 9, 1105AZ Amsterdam, Netherlands; Amsterdam UMC, Univ of Amsterdam, Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Meibergdreef 9, 1105AZ Amsterdam, Netherlands. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jcrc.2018.07.026DOI Listing
October 2018

Are histones real pathogenic agents in sepsis?

Nat Rev Immunol 2018 02 27;18(2):148. Epub 2017 Dec 27.

Department of Internal Medicine, and the Center for Infectious Diseases, Radboud University Medical Center, Geert Grooteplein Zuid 8, 6525 GA Nijmegen, Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nri.2017.157DOI Listing
February 2018

Biomarkers in Sepsis.

Crit Care Clin 2018 Jan 12;34(1):139-152. Epub 2017 Oct 12.

Division of Laboratory Specialties, Center for Experimental Molecular Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Room G2-130, Amsterdam 1105AZ, The Netherlands; Division of Infectious Diseases, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Room G2-130, Amsterdam 1105AZ, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ccc.2017.08.010DOI Listing
January 2018

The host response in critically ill sepsis patients on statin therapy: a prospective observational study.

Ann Intensive Care 2018 Jan 18;8(1). Epub 2018 Jan 18.

Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Room G2-130, 1105 AZ, Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13613-017-0349-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5773465PMC
January 2018

Association of Gender With Outcome and Host Response in Critically Ill Sepsis Patients.

Crit Care Med 2017 11;45(11):1854-1862

1Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands. 2The Center for Infection and Immunity, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands. 3Department of Clinical Epidemiology and Biostatistics, Academic Medical Center, Amsterdam, the Netherlands. 4Department of Intensive Care Medicine, University Medical Center Utrecht, Utrecht, the Netherlands. 5Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, the Netherlands. 6Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands. 7Department of Intensive Care, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands. 8Cologne Center for Genomics (CCG), University of Cologne, Cologne, Germany. 9Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany. 10Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany. 11Division of Infectious Diseases, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/CCM.0000000000002649DOI Listing
November 2017

Classification of patients with sepsis according to blood genomic endotype: a prospective cohort study.

Lancet Respir Med 2017 10 29;5(10):816-826. Epub 2017 Aug 29.

Center for Experimental Molecular Medicine, Academic Medical Center, Amsterdam, Netherlands; Division of Infectious Diseases, Academic Medical Center, Amsterdam, Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S2213-2600(17)30294-1DOI Listing
October 2017

The immunopathology of sepsis and potential therapeutic targets.

Nat Rev Immunol 2017 Jul 24;17(7):407-420. Epub 2017 Apr 24.

Department of Internal Medicine, Radboud University Medical Center.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nri.2017.36DOI Listing
July 2017

Sepsis Patients Display a Reduced Capacity to Activate Nuclear Factor-κB in Multiple Cell Types.

Crit Care Med 2017 May;45(5):e524-e531

1Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. 2Center for Infection and Immunity Amsterdam, Amsterdam, The Netherlands. 3Department of Intensive Care, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. 4Laboratory of Experimental Intensive Care and Anesthesiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. 5Division of Infectious Diseases, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/CCM.0000000000002294DOI Listing
May 2017

Turning a New Page in Sepsis Molecular Diagnostics Necessitates Context-Specific Biomarkers.

Crit Care Med 2017 04;45(4):e457

Center for Experimental Molecular Medicine and Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands;Center for Experimental Molecular Medicine and Division of Infectious Diseases, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/CCM.0000000000002214DOI Listing
April 2017

The gut microbiota as a modulator of innate immunity during melioidosis.

PLoS Negl Trop Dis 2017 04 19;11(4):e0005548. Epub 2017 Apr 19.

Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pntd.0005548DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5411098PMC
April 2017

Prior Use of Calcium Channel Blockers Is Associated With Decreased Mortality in Critically Ill Patients With Sepsis: A Prospective Observational Study.

Crit Care Med 2017 Mar;45(3):454-463

1Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands. 2The Center for Infection and Immunity Amsterdam, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands. 3Department of Clinical Epidemiology, Bioinformatics, and Biostatistics, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands. 4Department of Intensive Care, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands. 5Division of Infectious Diseases, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands. 6Department of Intensive Care Medicine, University Medical Center Utrecht, Utrecht, the Netherlands. 7Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands. 8Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, the Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/CCM.0000000000002236DOI Listing
March 2017

Risk factors, host response and outcome of hypothermic sepsis.

Crit Care 2016 10 14;20(1):328. Epub 2016 Oct 14.

Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13054-016-1510-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5064908PMC
October 2016

Association of diabetes and diabetes treatment with the host response in critically ill sepsis patients.

Crit Care 2016 Aug 6;20(1):252. Epub 2016 Aug 6.

Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, Room G2-130, 1105, AZ, Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13054-016-1429-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4975896PMC
August 2016

Admission Hyperglycemia in Critically Ill Sepsis Patients: Association With Outcome and Host Response.

Crit Care Med 2016 Jul;44(7):1338-46

1Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. 2The Center for Infection and Immunity, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. 3Department of Intensive Care Medicine, University Medical Center Utrecht, Utrecht, The Netherlands. 4Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, the Netherlands. 5Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands. 6Department of Intensive Care, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. 7Division of Infectious Diseases, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/CCM.0000000000001650DOI Listing
July 2016

Thrombocytopenia is associated with a dysregulated host response in critically ill sepsis patients.

Blood 2016 06 8;127(24):3062-72. Epub 2016 Mar 8.

Center for Experimental and Molecular Medicine, The Center for Infection and Immunity, and Division of Infectious Diseases, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2015-11-680744DOI Listing
June 2016

The gut microbiota plays a protective role in the host defence against pneumococcal pneumonia.

Gut 2016 Apr 28;65(4):575-83. Epub 2015 Oct 28.

Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands Department of Medicine, Division of Infectious Diseases, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/gutjnl-2015-309728DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4819612PMC
April 2016

Incidence, Risk Factors, and Attributable Mortality of Secondary Infections in the Intensive Care Unit After Admission for Sepsis.

JAMA 2016 Apr;315(14):1469-79

Center for Experimental and Molecular Medicine, Division of Infectious Diseases, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1001/jama.2016.2691DOI Listing
April 2016

Chemokine ligand 9 modulates cardiac repolarization via Cxcr3 receptor binding.

Int J Cardiol 2015 Dec 31;201:49-52. Epub 2015 Jul 31.

Department of Anatomy, Embryology and Physiology, Academic Medical Center, Amsterdam, The Netherlands. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijcard.2015.07.096DOI Listing
December 2015

Reply: Comprehensive Validation of the FAIM3:PLAC8 Ratio in Time-matched Public Gene Expression Data.

Am J Respir Crit Care Med 2015 Nov;192(10):1261-2

1 University of Amsterdam Amsterdam, the Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1164/rccm.201508-1552LEDOI Listing
November 2015

Plasma fractalkine is a sustained marker of disease severity and outcome in sepsis patients.

Crit Care 2015 Nov 25;19:412. Epub 2015 Nov 25.

Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, G2-130, 1105 AZ, Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13054-015-1125-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4658804PMC
November 2015

Reduced Responsiveness of Blood Leukocytes to Lipopolysaccharide Does not Predict Nosocomial Infections in Critically Ill Patients.

Shock 2015 Aug;44(2):110-4

*Center for Experimental and Molecular Medicine, †Department of Intensive Care, and ‡Division of Infectious Diseases, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.

View Article

Download full-text PDF

Source
http://pdfs.journals.lww.com/shockjournal/2015/08000/Reduced
Web Search
http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
Publisher Site
http://dx.doi.org/10.1097/SHK.0000000000000391DOI Listing
August 2015

The Selective Sirtuin 1 Activator SRT2104 Reduces Endotoxin-Induced Cytokine Release and Coagulation Activation in Humans.

Crit Care Med 2015 Jun;43(6):e199-202

1Center for Experimental Molecular Medicine (CEMM), Academic Medical Center, Amsterdam, The Netherlands. 2Bioinformatics Laboratory, Department of Clinical Epidemiology, Academic Medical Center, Amsterdam, The Netherlands. 3GlaxoSmithKline, Durham, North Carolina. 4Sirtris, A GSK Company, Cambridge, MA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/CCM.0000000000000949DOI Listing
June 2015

Modular Transcriptional Networks of the Host Pulmonary Response during Early and Late Pneumococcal Pneumonia.

Mol Med 2015 May 12;21:430-41. Epub 2015 May 12.

Center for Experimental Molecular Medicine and Center for Infection and Immunity Amsterdam.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2119/molmed.2014.00263DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4559533PMC
May 2015

IFN-γ priming of macrophages represses a part of the inflammatory program and attenuates neutrophil recruitment.

J Immunol 2015 Apr 6;194(8):3909-16. Epub 2015 Mar 6.

Experimental Vascular Biology Laboratory, Department of Medical Biochemistry, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, the Netherlands;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.1402077DOI Listing
April 2015

Integrative genomic approach identifies multiple genes involved in cardiac collagen deposition.

Circ Cardiovasc Genet 2014 Dec 12;7(6):790-8. Epub 2014 Sep 12.

From the Department of Experimental Cardiology (E.M.L., B.P.S., L.B., M.E.A., C.R.B.), and Department of Clinical Epidemiology, Biostatistics and Bioinformatics (P.D.M., M.W.T.T.), University of Amsterdam, Academic Medical Center, Amsterdam, Netherlands; and Groningen Bioinformatics Centre, University of Groningen, Groningen, Netherlands (D.A.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/CIRCGENETICS.114.000537DOI Listing
December 2014

Role of tumor necrosis factor-α in the human systemic endotoxin-induced transcriptome.

PLoS One 2013 13;8(11):e79051. Epub 2013 Nov 13.

Center for Experimental Molecular Medicine and Center for Infection and Immunity, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0079051PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3827317PMC
September 2014

NLRP3 and ASC differentially affect the lung transcriptome during pneumococcal pneumonia.

Am J Respir Cell Mol Biol 2014 Apr;50(4):699-712

1 Center of Infection and Immunity, Amsterdam, The Netherlands; and.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1165/rcmb.2013-0015OCDOI Listing
April 2014

Dissection of a quantitative trait locus for PR interval duration identifies Tnni3k as a novel modulator of cardiac conduction.

PLoS Genet 2012 6;8(12):e1003113. Epub 2012 Dec 6.

Heart Failure Research Center, Department of Experimental Cardiology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pgen.1003113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3516546PMC
May 2013

Functional Nav1.8 channels in intracardiac neurons: the link between SCN10A and cardiac electrophysiology.

Circ Res 2012 Jul 20;111(3):333-43. Epub 2012 Jun 20.

Department of Anatomy, Embryology, and Physiology, Heart Failure Research Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/CIRCRESAHA.112.274035DOI Listing
July 2012

Quantitative trait loci for electrocardiographic parameters and arrhythmia in the mouse.

J Mol Cell Cardiol 2011 Mar 18;50(3):380-9. Epub 2010 Sep 18.

Heart Failure Research Center, Department of Experimental Cardiology, University of Amsterdam, Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.yjmcc.2010.09.009DOI Listing
March 2011

Tubulin polymerization modifies cardiac sodium channel expression and gating.

Cardiovasc Res 2010 Mar 26;85(4):691-700. Epub 2009 Oct 26.

Department of Clinical and Experimental Cardiology, Heart Failure Research Center, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/cvr/cvp352DOI Listing
March 2010

The primary arrhythmia syndromes: same mutation, different manifestations. Are we starting to understand why?

J Cardiovasc Electrophysiol 2008 Apr 12;19(4):445-52. Epub 2008 Feb 12.

Heart Failure Research Center, Department of Experimental Cardiology, Academic Medical Center, Amsterdam, The Netherlands.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/j.1540-8167.2007.01073.x
Publisher Site
http://dx.doi.org/10.1111/j.1540-8167.2007.01073.xDOI Listing
April 2008