Brenden Chen

Brenden Chen

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Brenden Chen

Brenden Chen

Publications by authors named "Brenden Chen"

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Identification and characterization of 40 novel hydroxymethylbilane synthase mutations that cause acute intermittent porphyria.

J Inherit Metab Dis 2019 Jan;42(1):186-194

Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue Room 14-34, New York, NY 10029, USA.

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http://dx.doi.org/10.1002/jimd.12040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162174PMC
January 2019

Characterization of the hepatic transcriptome following phenobarbital induction in mice with AIP.

Mol Genet Metab 2019 Jan 6. Epub 2019 Jan 6.

Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10967192183048
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http://dx.doi.org/10.1016/j.ymgme.2018.12.010DOI Listing
January 2019

Porphyria cutanea tarda and hepatoerythropoietic porphyria: Identification of 19 novel uroporphyrinogen III decarboxylase mutations.

Mol Genet Metab 2018 Nov 28. Epub 2018 Nov 28.

Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ymgme.2018.11.013DOI Listing
November 2018

Recent advances on porphyria genetics: Inheritance, penetrance & molecular heterogeneity, including new modifying/causative genes.

Mol Genet Metab 2018 Nov 30. Epub 2018 Nov 30.

Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States. Electronic address:

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http://dx.doi.org/10.1016/j.ymgme.2018.11.012DOI Listing
November 2018

Acute hepatic porphyrias: Identification of 46 hydroxymethylbilane synthase, 11 coproporphyrinogen oxidase, and 20 protoporphyrinogen oxidase novel mutations.

Mol Genet Metab 2018 Oct 26. Epub 2018 Oct 26.

Icahn School of Medicine at Mount Sinai, Department of Genetics and Genomic Sciences, New York, NY 10029, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10967192183048
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http://dx.doi.org/10.1016/j.ymgme.2018.10.008DOI Listing
October 2018

Congenital erythropoietic porphyria and erythropoietic protoporphyria: Identification of 7 uroporphyrinogen III synthase and 20 ferrochelatase novel mutations.

Mol Genet Metab 2018 Aug 31. Epub 2018 Aug 31.

Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10967192183048
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http://dx.doi.org/10.1016/j.ymgme.2018.08.015DOI Listing
August 2018

Fabry Disease: prevalence of affected males and heterozygotes with pathogenic mutations identified by screening renal, cardiac and stroke clinics, 1995-2017.

J Med Genet 2018 Apr 12;55(4):261-268. Epub 2018 Jan 12.

Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

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http://jmg.bmj.com/lookup/doi/10.1136/jmedgenet-2017-105080
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http://dx.doi.org/10.1136/jmedgenet-2017-105080DOI Listing
April 2018

Human hydroxymethylbilane synthase: Molecular dynamics of the pyrrole chain elongation identifies step-specific residues that cause AIP.

Proc Natl Acad Sci U S A 2018 04 9;115(17):E4071-E4080. Epub 2018 Apr 9.

Life Sciences Division, TCS Innovation Labs-Hyderabad, Tata Consultancy Services Limited, Hyderabad 500081, India;

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http://dx.doi.org/10.1073/pnas.1719267115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5924904PMC
April 2018

Focal facial dermal dysplasia type 4: identification of novel CYP26C1 mutations in unrelated patients.

J Hum Genet 2018 Mar 20;63(3):257-261. Epub 2017 Dec 20.

Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

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http://www.nature.com/articles/s10038-017-0375-x
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http://dx.doi.org/10.1038/s10038-017-0375-xDOI Listing
March 2018

The focal facial dermal dysplasias: phenotypic spectrum and molecular genetic heterogeneity.

J Med Genet 2017 09 29;54(9):585-590. Epub 2017 Jun 29.

Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, USA.

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http://dx.doi.org/10.1136/jmedgenet-2017-104561DOI Listing
September 2017

Fabry Disease in Families With Hypertrophic Cardiomyopathy: Clinical Manifestations in the Classic and Later-Onset Phenotypes.

Circ Cardiovasc Genet 2017 Aug;10(4)

From the Faculty of Medicine, University of Iceland, Reykjavik, Iceland (B.A., R.P., R.A., G.T.G.); Division of Cardiology (B.A., R.D.), Department of Genetics (R.A.), Division of Nephrology (R.P.), and Department of Radiology (M.G.), Landspitali-The National University Hospital of Iceland, Reykjavik, Iceland; Department of Cardiology, Haukeland University Hospital, Bergen, Norway (B.A.); Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY (R.J.D., B.C., S.P.); Department of Genetics, Harvard Medical School, Boston, MA (P.T., M.A.B., J.G.S., C.E.S.); Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA (E.A., U.N.); Division of Cardiology, Hypertrophic Cardiomyopathy Center, Tufts Medical Center, Boston, MA (M.M., B.J.M.); Cardiovascular Division, Brigham and Women's Hospital, Boston, MA (M.A.B., C.E.S.); Division of Cardiology, Emory University School of Medicine, Atlanta, GA (M.A.B.); Department of Medical Endocrinology, Rigshospitalet and University of Copenhagen, Denmark (C.V.M., U.F.-R.); Howard Hughes Medical Institute, Boston, MA (C.E.S.); and Department of Medicine, Akureyri Hospital, Iceland (G.T.G.).

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http://dx.doi.org/10.1161/CIRCGENETICS.116.001639DOI Listing
August 2017

Acute Intermittent Porphyria in children: A case report and review of the literature.

Mol Genet Metab 2016 12 15;119(4):295-299. Epub 2016 Oct 15.

Department of Genetics and Genomic Science, Icahn School of Medicine at Mount Sinai, United States. Electronic address:

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http://dx.doi.org/10.1016/j.ymgme.2016.10.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5154763PMC
December 2016

Setleis syndrome due to inheritance of the 1p36.22p36.21 duplication: evidence for lack of penetrance.

J Hum Genet 2015 Nov 27;60(11):717-22. Epub 2015 Aug 27.

Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

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http://dx.doi.org/10.1038/jhg.2015.103DOI Listing
November 2015

BRAFV600E negatively regulates the AKT pathway in melanoma cell lines.

PLoS One 2012 3;7(8):e42598. Epub 2012 Aug 3.

Discovery Oncology, Hoffmann-La Roche Inc, Nutley, New Jersey, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0042598PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3411810PMC
January 2013

Non-transcriptional control of DNA replication by c-Myc.

Nature 2007 Jul 27;448(7152):445-51. Epub 2007 Jun 27.

Institute for Cancer Genetics, Department of Genetics and Development and Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, New York 10032, USA.

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http://dx.doi.org/10.1038/nature05953DOI Listing
July 2007

VEGF activates divergent intracellular signaling components to regulate retinal progenitor cell proliferation and neuronal differentiation.

Development 2006 Jun 3;133(11):2201-10. Epub 2006 May 3.

Jules Stein Eye Institute and Department of Ophthalmology, Molecular Biology Institute, University of California, David Geffen School of Medicine, Los Angeles, 90095, USA.

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http://dx.doi.org/10.1242/dev.02385DOI Listing
June 2006