Brendan H Lee

Brendan H Lee

UNVERIFIED PROFILE

Are you Brendan H Lee?   Register this Author

Register author
Brendan H Lee

Brendan H Lee

Publications by authors named "Brendan H Lee"

Are you Brendan H Lee?   Register this Author

66Publications

2970Reads

32Profile Views

Notch Signaling in Skeletal Development, Homeostasis and Pathogenesis.

Biomolecules 2020 Feb 19;10(2). Epub 2020 Feb 19.

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/biom10020332DOI Listing
February 2020

Using the Delphi method to identify clinicians' perceived importance of pediatric exome sequencing results.

Genet Med 2020 01 5;22(1):69-76. Epub 2019 Jul 5.

Baylor College of Medicine, Center for Medical Ethics and Health Policy, Houston, TX, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41436-019-0601-3DOI Listing
January 2020

Bmi1 Suppresses Adipogenesis in the Hematopoietic Stem Cell Niche.

Stem Cell Reports 2019 09 27;13(3):545-558. Epub 2019 Jun 27.

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.stemcr.2019.05.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6739622PMC
September 2019

Mutations in ANAPC1, Encoding a Scaffold Subunit of the Anaphase-Promoting Complex, Cause Rothmund-Thomson Syndrome Type 1.

Am J Hum Genet 2019 Sep 11;105(3):625-630. Epub 2019 Jul 11.

Centre Hospitalier Universitaire Sainte-Justine Research Center, University of Montreal, Montreal, QC H3T 1C5, Canada; Department of Pediatrics, University of Montreal, Montreal, QC H3T 1C5, Canada. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ajhg.2019.06.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6731352PMC
September 2019

Recurrent mosaic MTOR c.5930C > T (p.Thr1977Ile) variant causing megalencephaly, asymmetric polymicrogyria, and cutaneous pigmentary mosaicism: Case report and review of the literature.

Am J Med Genet A 2019 03 19;179(3):475-479. Epub 2018 Dec 19.

Department of Pediatrics, Section of Neurology and Developmental Neuroscience, Baylor College of Medicine, Houston, Texas.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ajmg.a.61007DOI Listing
March 2019

Disease-Modifying Osteoarthritis Treatment With Interleukin-1 Receptor Antagonist Gene Therapy in Small and Large Animal Models.

Arthritis Rheumatol 2018 11 10;70(11):1757-1768. Epub 2018 Sep 10.

Baylor College of Medicine, Houston, Texas, and GeneQuine Biotherapeutics GmbH, Hamburg, Germany.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/art.40668
Publisher Site
http://dx.doi.org/10.1002/art.40668DOI Listing
November 2018

Heterozygous WNT1 variant causing a variable bone phenotype.

Am J Med Genet A 2018 11 24;176(11):2419-2424. Epub 2018 Sep 24.

University of California, San Diego, La Jolla, California.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ajmg.a.40347DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6289778PMC
November 2018

Effect of Genetic Diagnosis on Patients with Previously Undiagnosed Disease.

N Engl J Med 2018 11 10;379(22):2131-2139. Epub 2018 Oct 10.

From Harvard Medical School (K.S., C.E., I.S.K., J.L., A.T.M., D.A.S.), Brigham and Women's Hospital (J.L.), and Massachusetts General Hospital (D.A.S.) - all in Boston; the National Institutes of Health Clinical Center (D.R.A., W.A.G., J.J.M., C.J.T.) and the National Human Genome Research Institute (A.L.W.), Bethesda, and the University of Maryland, College Park (A.M.C.-J., B.K., L.P.) - all in Maryland; Baylor College of Medicine, Houston (C.A.B., H.J.B., C.M.E., B.H.L., X.L., M.F.W., S.Y.); Stanford University, Stanford (J.A.B., C.R., M.T.W., E.A.A.), and the University of California, Los Angeles, Los Angeles (S.F.N., C.G.S.P.) - both in California; Vanderbilt University, Nashville (R.H., J.A.P.); HudsonAlpha Institute for Biotechnology, Huntsville, AL (H.J.J., E.A.W.); Oregon Health and Science University, Portland (D.M.K.); the Pacific Northwest National Laboratory, Richland, WA (T.O.M.); the University of Oregon, Eugene (J.H.P., M.W.); and Duke University, Durham, NC (V.S., N.M.W.).

View Article

Download full-text PDF

Source
http://www.nejm.org/doi/10.1056/NEJMoa1714458
Publisher Site
http://dx.doi.org/10.1056/NEJMoa1714458DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6481166PMC
November 2018

Atypical Alexander disease with dystonia, retinopathy, and a brain mass mimicking astrocytoma.

Neurol Genet 2018 Aug 20;4(4):e248. Epub 2018 Jul 20.

Department of Molecular and Human Genetics (K.M., L.C.B., M.J., R.A.L., M.X., J.A.R., R.C., C.M.E., Y.Y., B.H.L., P.M.M., S.U.D.), Department of Neurology (J.J., D.V., P.M.M), and Department of Ophthalmology (R.A.L.), Baylor College of Medicine; Department of Pathology (G.N.F.), Department of Neuro-Oncology (M.P.-P.), and Department of Diagnostic Imaging (M.K.G.-M.), The University of Texas MD Anderson Cancer Center; Michael E. DeBakey VA Medical Center (P.M.M.); Baylor Genetics (C.M.E., Y.Y.); and Department of Medicine (S.U.D.), Baylor College of Medicine, Houston, TX.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1212/NXG.0000000000000248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6055357PMC
August 2018

Argininosuccinate Lyase Deficiency Causes an Endothelial-Dependent Form of Hypertension.

Am J Hum Genet 2018 08;103(2):276-287

Program in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, USA; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ajhg.2018.07.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6080833PMC
August 2018

Gene therapy for repair and regeneration of bone and cartilage.

Curr Opin Pharmacol 2018 06 2;40:59-66. Epub 2018 Apr 2.

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S14714892183000
Publisher Site
http://dx.doi.org/10.1016/j.coph.2018.03.005DOI Listing
June 2018

mTORC1 Signaling is a Critical Regulator of Postnatal Tendon Development.

Sci Rep 2017 12 7;7(1):17175. Epub 2017 Dec 7.

Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX, 77030, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-017-17384-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5719403PMC
December 2017

Osteocyte-specific WNT1 regulates osteoblast function during bone homeostasis.

J Clin Invest 2017 Jun 19;127(7):2678-2688. Epub 2017 Jun 19.

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1172/JCI92617DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5490765PMC
June 2017

MicroRNA miR-23a cluster promotes osteocyte differentiation by regulating TGF-β signalling in osteoblasts.

Nat Commun 2017 04 11;8:15000. Epub 2017 Apr 11.

Program in Developmental Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ncomms15000DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5394267PMC
April 2017

P3h3-null and Sc65-null Mice Phenocopy the Collagen Lysine Under-hydroxylation and Cross-linking Abnormality of Ehlers-Danlos Syndrome Type VIA.

J Biol Chem 2017 03 23;292(9):3877-3887. Epub 2017 Jan 23.

From the Department of Orthopaedics and Sports Medicine, University of Washington, Seattle, Washington 98195.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M116.762245DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5339768PMC
March 2017

Intra-iliac Artery Injection for Efficient and Selective Modeling of Microscopic Bone Metastasis.

J Vis Exp 2016 09 26(115). Epub 2016 Sep 26.

Lester and Sue Smith Breast Center, Baylor College of Medicine; Department of Molecular and Cellular Biology, Baylor College of Medicine; McNair Medical Institute, Baylor College of Medicine; Dan L. Duncan Cancer Center, Baylor College of Medicine;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3791/53982DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5092070PMC
September 2016

Sodium phenylbutyrate decreases plasma branched-chain amino acids in patients with urea cycle disorders.

Mol Genet Metab 2014 Sep-Oct;113(1-2):131-5. Epub 2014 Jul 3.

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ymgme.2014.06.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4177960PMC
June 2015

Adult presentation of X-linked Conradi-Hünermann-Happle syndrome.

Am J Med Genet A 2015 Jun 2;167(6):1309-14. Epub 2015 Apr 2.

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ajmg.a.36899DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4449285PMC
June 2015

Autosomal-Dominant Multiple Pterygium Syndrome Is Caused by Mutations in MYH3.

Am J Hum Genet 2015 May;96(5):841-9

Division of Genetic Medicine, Department of Pediatrics, University of Washington, Seattle, WA 98195, USA; Division of Genetic Medicine, Seattle Children's Hospital, Seattle, WA 98105, USA; Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ajhg.2015.04.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4570285PMC
May 2015

Exome sequencing identifies a novel homozygous mutation in the phosphate transporter SLC34A1 in hypophosphatemia and nephrocalcinosis.

J Clin Endocrinol Metab 2014 Nov 22;99(11):E2451-6. Epub 2014 Jul 22.

Department of Molecular and Human Genetics (A.R., D.L., R.G., P.C., B.L.), Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030; Centro de Investigaciones Endocrinológicas "Dr. César Bergadá" (CEDIE) (D.B., F.C., H.C., I.B.), CONICET - FEI - División de Endocrinología, Hospital de Niños Ricardo Gutiérrez, C1425FD Buenos Aires, Argentina; Human Genome Sequencing Center (J.T.L., R.G.), Department of Structural and Computational Biology and Molecular Biophysics (J.T.L.), Baylor College of Medicine, Houston, Texas 77030; Unidad de Metabolismo (S.K.), Hospital de Niños Ricardo Gutiérrez, C1425FD Buenos Aires, Argentina; Unidad de Nefrología (J.M.L., G.V.), Hospital de Niños Ricardo Gutiérrez, C1425FD Buenos Aires, Argentina; Howard Hughes Medical Institute (B.L.), Houston, Texas 77030.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/jc.2014-1517DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4223446PMC
November 2014

Branched-chain amino acid metabolism: from rare Mendelian diseases to more common disorders.

Hum Mol Genet 2014 Sep 20;23(R1):R1-8. Epub 2014 Mar 20.

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA Howard Hughes Medical Institute, Houston, TX 77030, USA

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/hmg/ddu123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4170715PMC
September 2014

Notch activation as a driver of osteogenic sarcoma.

Cancer Cell 2014 Sep;26(3):390-401

Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, R815, Houston, TX 77030, USA; Program in Developmental Biology, Baylor College of Medicine, One Baylor Plaza, R815, Houston, TX 77030, USA; Howard Hughes Medical Institute, Houston, TX 77030, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ccr.2014.07.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4159617PMC
September 2014

The swaying mouse as a model of osteogenesis imperfecta caused by WNT1 mutations.

Hum Mol Genet 2014 Aug 14;23(15):4035-42. Epub 2014 Mar 14.

Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA Howard Hughes Medical Institute, One Baylor Plaza, Houston, TX 77030, USA

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/hmg/ddu117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4082367PMC
August 2014

Genotype-phenotype correlation--promiscuity in the era of next-generation sequencing.

N Engl J Med 2014 Aug;371(7):593-6

From the Human Genome Sequencing Center and the Department of Structural and Computational Biology and Molecular Biophysics (J.T.L.), and the Department of Molecular and Human Genetics (B.H.L)., Baylor College of Medicine; and the Howard Hughes Medical Institutes (B.H.L.) - both in Houston; and the Medical Genetics Service, Department of Pediatrics, Sainte-Justine Hospital, University of Montreal, Montreal (P.M.C.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1056/NEJMp1400788DOI Listing
August 2014

Notch signaling in skeletal stem cells.

Calcif Tissue Int 2014 Jan 22;94(1):68-77. Epub 2013 Aug 22.

Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza Rm R814, Houston, TX, 77030, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00223-013-9773-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3947214PMC
January 2014

Differential effects of collagen prolyl 3-hydroxylation on skeletal tissues.

PLoS Genet 2014 Jan 23;10(1):e1004121. Epub 2014 Jan 23.

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America ; Howard Hughes Medical Institute, Baylor College of Medicine, Houston, Texas, United States of America.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.pgen.1004121DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3900401PMC
January 2014

Diagnosis of ALG12-CDG by exome sequencing in a case of severe skeletal dysplasia.

Mol Genet Metab Rep 2014 ;1:213-219

Medical Genetics Service, Department of Pediatrics, Sainte-Justine Hospital, University of Montreal; Medical genetics service, Room 6727, Sainte-Justine Hospital, 3175, Côte-Sainte-Catherine, Montréal QC Canada H3T 1C5.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ymgmr.2014.04.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4088274PMC
January 2014

Lysinuric Protein Intolerance Presenting with Multiple Fractures.

Mol Genet Metab Rep 2014 ;1:176-183

Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Suite R814, Houston, TX, 77030-3411, USA ; Howard Hughes Medical Institute, Houston, TX, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ymgmr.2014.03.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4235665PMC
January 2014

Osteogenesis imperfecta without features of type V caused by a mutation in the IFITM5 gene.

J Bone Miner Res 2013 Nov;28(11):2333-7

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jbmr.1983DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3800501PMC
November 2013

Early childhood presentation of Czech dysplasia.

Clin Dysmorphol 2013 Apr;22(2):76-80

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MCD.0b013e32835fff39DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3673284PMC
April 2013

Proteoglycan 4 expression protects against the development of osteoarthritis.

Sci Transl Med 2013 Mar;5(176):176ra34

Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, MS 227, Houston, TX 77030, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/scitranslmed.3005409DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3804124PMC
March 2013

Assessment of bone mineral status in children with Marfan syndrome.

Am J Med Genet A 2012 Sep 7;158A(9):2221-4. Epub 2012 Aug 7.

Department of Pediatric Diabetes and Endocrinology, Baylor College of Medicine, Houston, Texas 77030-3411, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ajmg.a.35540DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3429634PMC
September 2012

miRNA-34c regulates Notch signaling during bone development.

Hum Mol Genet 2012 Jul 12;21(13):2991-3000. Epub 2012 Apr 12.

Department of Molecular and Human Genetics, Baylor College of Medicine,One Baylor Plaza, Houston, TX 77030, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/hmg/dds129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3373245PMC
July 2012

Decreased bone mineralization in children with Noonan syndrome: another consequence of dysregulated RAS MAPKinase pathway?

Mol Genet Metab 2012 Jun 11;106(2):237-40. Epub 2012 Apr 11.

Department of Pediatrics (Division of Endocrinology and Metabolism), Baylor College of Medicine, Houston, TX, USA.

View Article

Download full-text PDF

Source
http://linkinghub.elsevier.com/retrieve/pii/S109671921200126
Publisher Site
http://dx.doi.org/10.1016/j.ymgme.2012.04.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3356458PMC
June 2012

Early orthotopic liver transplantation in urea cycle defects: follow up of a developmental outcome study.

Mol Genet Metab 2010 19;100 Suppl 1:S84-7. Epub 2010 Feb 19.

Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ymgme.2010.02.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2867349PMC
July 2010

Heritability of plasma amino acid levels in different nutritional states.

Mol Genet Metab 2007 Feb 26;90(2):217-20. Epub 2006 Sep 26.

Center for Molecular and Human Genetics, Columbus Children's Research Institute, Department of Pediatrics, The Ohio State University, Columbus, OH 43205, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ymgme.2006.08.010DOI Listing
February 2007