Publications by authors named "Brendan D Manning"

88Publications

IMPDH inhibitors for antitumor therapy in tuberous sclerosis complex.

JCI Insight 2020 04 9;5(7). Epub 2020 Apr 9.

Department of Molecular Metabolism, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.

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April 2020

The PI3K-AKT network at the interface of oncogenic signalling and cancer metabolism.

Nat Rev Cancer 2020 02 4;20(2):74-88. Epub 2019 Nov 4.

Department of Molecular Metabolism, Harvard T. H. Chan School of Public Health, Boston, MA, USA.

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February 2020

Molecular logic of mTORC1 signalling as a metabolic rheostat.

Nat Metab 2019 03 4;1(3):321-333. Epub 2019 Mar 4.

Department of Genetics and Complex Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

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March 2019

Lysosomal catch-and-release controls mTORC1.

Nat Cell Biol 2018 Sep;20(9):996-997

Department of Genetics and Complex Diseases, Harvard T. H. Chan School of Public Health, Boston, MA, USA.

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September 2018

Improved detection of synthetic lethal interactions in cells using variable dose analysis (VDA).

Proc Natl Acad Sci U S A 2017 12 28;114(50):E10755-E10762. Epub 2017 Nov 28.

Department of Genetics, Harvard Medical School, Boston, MA 02115;

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December 2017

mTORC1 suppresses PIM3 expression via miR-33 encoded by the SREBP loci.

Sci Rep 2017 11 23;7(1):16112. Epub 2017 Nov 23.

Department of Genetics and Complex Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

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November 2017

The mTORC1 Signaling Network Senses Changes in Cellular Purine Nucleotide Levels.

Cell Rep 2017 Oct;21(5):1331-1346

Department of Genetics and Complex Diseases, Harvard T. H. Chan School of Public Health, Boston, MA, USA. Electronic address:

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October 2017

Game of TOR - The Target of Rapamycin Rules Four Kingdoms.

N Engl J Med 2017 Sep 5;377(13):1297-9. Epub 2017 Sep 5.

From the Department of Genetics and Complex Diseases, Harvard T.H. Chan School of Public Health, Boston.

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September 2017

A relative quantitative positive/negative ion switching method for untargeted lipidomics via high resolution LC-MS/MS from any biological source.

Metabolomics 2017 Mar 7;13(3). Epub 2017 Feb 7.

Division of Signal Transduction/Mass Spectrometry Core, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA.

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March 2017

AKT/PKB Signaling: Navigating the Network.

Cell 2017 04;169(3):381-405

Department of Pathology and Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School, and Ludwig Center at Harvard, Boston, MA 02215, USA. Electronic address:

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April 2017