Brenda Gerull

Brenda Gerull

UNVERIFIED PROFILE

Are you Brenda Gerull?   Register this Author

Register author
Brenda Gerull

Brenda Gerull

Publications by authors named "Brenda Gerull"

Are you Brenda Gerull?   Register this Author

44Publications

941Reads

13Profile Views

Biallelic mutation in MYH7 and MYBPC3 leads to severe cardiomyopathy with left ventricular noncompaction phenotype.

Hum Mutat 2019 Aug 24;40(8):1101-1114. Epub 2019 Apr 24.

Comprehensive Heart Failure Center (CHFC) and Department of Medicine I, University and University Hospital Würzburg, Würzburg, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/humu.23757DOI Listing
August 2019

The Pore-Lipid Interface: Role of Amino-Acid Determinants of Lipophilic Access by Ivabradine to the hERG1 Pore Domain.

Mol Pharmacol 2019 Aug 10;96(2):259-271. Epub 2019 Jun 10.

Centre for Molecular Simulation, Department of Biological Sciences, University of Calgary, Calgary, Alberta, Canada (L.P., M.K., S.Y.N.); Libin Cardiovascular Institute of Alberta (J.G., J.-L.M., H.J.D.) and Snyder Institute for Chronic Diseases (D.A.M.), Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada; Institute of Solution Chemistry, Russian Academy of Sciences, Ivanovo, Russian Federation (M.O., A.S., G.L.P.); Department of Cardiac Sciences and Libin Cardiovascular Institute of Alberta, University of Calgary, Calgary, Alberta, Canada (B.G.); and Comprehensive Heart Failure Center and Department of Internal Medicine I, University Hospital Würzburg, Würzburg, Germany (B.G.)

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1124/mol.118.115642DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6666383PMC
August 2019

Mutations in ILK, encoding integrin-linked kinase, are associated with arrhythmogenic cardiomyopathy.

Transl Res 2019 06 15;208:15-29. Epub 2019 Feb 15.

Department of Cardiac Sciences, Libin Cardiovascular Institute of Alberta, University of Calgary, Calgary, Alberta, Canada; Comprehensive Heart Failure Center and Department of Internal Medicine I, University Hospital Würzburg, Würzburg, Germany. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.trsl.2019.02.004DOI Listing
June 2019

Characterization of a Unique Form of Arrhythmic Cardiomyopathy Caused by Recessive Mutation in LEMD2.

JACC Basic Transl Sci 2019 Apr 29;4(2):204-221. Epub 2019 Apr 29.

Department of Cardiac Sciences, Libin Cardiovascular Institute of Alberta, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jacbts.2018.12.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6488817PMC
April 2019

Genetic Association Study in Multigenerational Kindreds With Vasovagal Syncope.

Circ Arrhythm Electrophysiol 2019 Jan;12(1):e006884

Libin Cardiovascular Institute of Calgary, Alberta, Canada (R.S., M.S.R., D.R., K.M., C.M., J.J., B.G.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/CIRCEP.118.006884DOI Listing
January 2019

Between Disease-Causing and an Innocent Bystander: The Role of Titin as a Modifier in Hypertrophic Cardiomyopathy.

Authors:
Brenda Gerull

Can J Cardiol 2017 10 21;33(10):1217-1220. Epub 2017 Jul 21.

Comprehensive Heart Failure Center and Department of Internal Medicine I, University Hospital Würzburg, Würzburg, Germany; Department of Cardiac Sciences and Libin Cardiovascular Institute of Alberta, University of Calgary, Calgary, Alberta, Canada. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cjca.2017.07.010DOI Listing
October 2017

Reversible Dilated Cardiomyopathy Caused by a High Burden of Ventricular Arrhythmias in Andersen-Tawil Syndrome.

Can J Cardiol 2016 12 27;32(12):1576.e15-1576.e18. Epub 2016 Jul 27.

Department of Cardiac Sciences and Libin Cardiovascular Institute of Alberta, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada; Department of Medical Genetics, University of Calgary and Alberta Health Services, Calgary, Alberta, Canada; Comprehensive Heart Failure Center and Department of Medicine I, University Hospital Würzburg, Würzburg, Germany. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cjca.2016.07.587DOI Listing
December 2016

Mutations in FLNC are Associated with Familial Restrictive Cardiomyopathy.

Hum Mutat 2016 Mar 8;37(3):269-79. Epub 2016 Jan 8.

Department of Cardiac Sciences, Libin Cardiovascular Institute of Alberta, University of Calgary, Calgary, Alberta, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/humu.22942DOI Listing
March 2016

Functional characterization of the novel DES mutation p.L136P associated with dilated cardiomyopathy reveals a dominant filament assembly defect.

J Mol Cell Cardiol 2016 Feb 23;91:207-14. Epub 2015 Dec 23.

Erich and Hanna Klessmann Institute for Cardiovascular Research & Development (EHKI), Heart and Diabetes Center NRW, Ruhr University Bochum, D-32545 Bad Oeynhausen, Germany. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.yjmcc.2015.12.015DOI Listing
February 2016

Outcome of Apparently Unexplained Cardiac Arrest: Results From Investigation and Follow-Up of the Prospective Cardiac Arrest Survivors With Preserved Ejection Fraction Registry.

Circ Arrhythm Electrophysiol 2016 Jan;9(1):e003619

From the Division of Cardiology, Department of Medicine, University of British Columbia, Vancouver, BC, Canada (A.R.M.H., C.C., K.G., M.T.B., C.S., M.J., S.C., A.D.K.); Department of Cardiovascular Sciences, Libin Cardiovascular Institute, University of Calgary, Calgary, AB, Canada (B.G.); Division of Cardiology, Department of Medicine, Queen's University, Kingston, ON, Canada (C.S.S.); University of Ottawa Heart Institute, Ottawa, ON, Canada (D.H.B.); Division of Cardiology, Department of Medicine, Western University, London, ON, Canada (G.J.K., R.Y.); Department of Medicine, Quebec Heart and Lung Institute, Quebec City, QC, Canada (J.C.); Division of Cardiology, Department of Medicine, Population Health Research Institute, Hamilton, ON, Canada (J.S.H.); Department of Medicine, Montreal Heart Institute, Université de Montréal, Montreal, QC, Canada (M.T.); Division of Cardiology, Department of Medicine, QEII Health Sciences Center, Halifax, NS, Canada (M.G.); Division of Cardiology, Department of Medicine, University Health Network, Toronto, ON, Canada (M.H.G., V.S.C.); Division of Cardiology, Department of Medicine, St. Michael's Hospital, University of Toronto, Toronto, ON, Canada (P.A.); Division of Cardiology, Department of Medicine, Royal Jubilee Hospital, Victoria, BC, Canada (R.L.); and Division of Cardiology, Department of Pediatrics, BC Children's Hospital, Vancouver, BC, Canada (S.S.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/CIRCEP.115.003619DOI Listing
January 2016

The Rapidly Evolving Role of Titin in Cardiac Physiology and Cardiomyopathy.

Authors:
Brenda Gerull

Can J Cardiol 2015 Nov 28;31(11):1351-9. Epub 2015 Aug 28.

Department of Cardiac Sciences, Libin Cardiovascular Institute of Alberta, University of Calgary, Calgary, Alberta, Canada; Department of Medical Genetics, University of Calgary and Alberta Health Services, Calgary, Alberta, Canada. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cjca.2015.08.016DOI Listing
November 2015

Early repolarization syndrome: A case report focusing on dynamic electrocardiographic changes before ventricular arrhythmias and genetic analysis.

HeartRhythm Case Rep 2015 Jul 2;1(4):213-216. Epub 2015 Apr 2.

Department of Cardiac Sciences, Libin Cardiovascular Institute of Alberta, University of Calgary, Alberta, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.hrcr.2015.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5419330PMC
July 2015

Congenital long QT syndrome: severe torsades de pointes provoked by epinephrine in a digenic mutation carrier.

Heart Lung 2014 Nov-Dec;43(6):541-5. Epub 2014 Sep 16.

Department of Cardiac Sciences, Libin Cardiovascular Institute of Alberta, University of Calgary, Calgary, AB, Canada. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.hrtlng.2014.07.004DOI Listing
June 2015

Phenotypic analysis of arrhythmogenic cardiomyopathy in the Hutterite population: role of electrocardiogram in identifying high-risk desmocollin-2 carriers.

J Am Heart Assoc 2014 Dec 11;3(6):e001407. Epub 2014 Dec 11.

Libin Cardiovascular Institute of Alberta & Department of Cardiac Sciences, University of Calgary, Alberta, Canada (J.A.W., H.J.D., T.Y., L.K., D.V.E., S.G.W., B.G.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/JAHA.114.001407DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338736PMC
December 2014

Skin-heart connection: what can the epidermis tell us about the myocardium in arrhythmogenic cardiomyopathy?

Authors:
Brenda Gerull

Circ Cardiovasc Genet 2014 Jun;7(3):225-7

From the Department of Cardiac Sciences, Libin Cardiovascular Institute of Alberta, University of Calgary, Calgary, Alberta, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/CIRCGENETICS.114.000647DOI Listing
June 2014

Exome sequencing identifies a novel variant in ACTC1 associated with familial atrial septal defect.

Can J Cardiol 2014 Feb 6;30(2):181-7. Epub 2013 Dec 6.

Department of Cardiac Sciences, University of Calgary and Libin Cardiovascular Institute of Alberta, Calgary, Alberta, Canada; Department of Medical Genetics, University of Calgary, Calgary, Alberta, Canada. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S0828282X130171
Publisher Site
http://dx.doi.org/10.1016/j.cjca.2013.12.003DOI Listing
February 2014

Titin mutation in familial restrictive cardiomyopathy.

Int J Cardiol 2014 Jan 25;171(1):24-30. Epub 2013 Nov 25.

Heart Failure Service and Heart Institute, Tel Aviv University, Tel Aviv, Israel. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijcard.2013.11.037DOI Listing
January 2014

Homozygous founder mutation in desmocollin-2 (DSC2) causes arrhythmogenic cardiomyopathy in the Hutterite population.

Circ Cardiovasc Genet 2013 Aug 17;6(4):327-36. Epub 2013 Jul 17.

Department of Cardiac Sciences, Libin Cardiovascular Institute of Alberta, Calgary, AB, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/CIRCGENETICS.113.000097DOI Listing
August 2013

Novel c.367_369del LMNA mutation manifesting as severe arrhythmias, dilated cardiomyopathy, and myopathy.

Heart Lung 2012 Jul-Aug;41(4):382-6. Epub 2011 Oct 21.

Second Medical Department, Krankenanstalt Rudolfstiftung, Vienna, Austria.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.hrtlng.2011.07.007DOI Listing
November 2012

A novel titin mutation in adult-onset familial dilated cardiomyopathy.

Am J Cardiol 2012 Jun 3;109(11):1644-50. Epub 2012 Apr 3.

Heart Failure Service and Heart Institute, Sheba Medical Center, Tel Hashomer, Tel Aviv University, Tel Aviv, Israel.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.amjcard.2012.01.392DOI Listing
June 2012

Mutant desmocollin-2 causes arrhythmogenic right ventricular cardiomyopathy.

Am J Hum Genet 2006 Dec 3;79(6):1081-8. Epub 2006 Oct 3.

Max-Delbrueck Center for Molecular Medicine, Franz-Volhard Clinic, HELIOS Clinics GmbH, Charité, Humboldt University, Berlin, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1086/509044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1698714PMC
December 2006

Identification of a novel frameshift mutation in the giant muscle filament titin in a large Australian family with dilated cardiomyopathy.

J Mol Med (Berl) 2006 Jun 6;84(6):478-83. Epub 2006 May 6.

Max-Delbrueck Center for Molecular Medicine, Robert-Roessle-Str. 10, 13092, Berlin-Buch, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00109-006-0060-6DOI Listing
June 2006

Titin isoform-dependent effect of calcium on passive myocardial tension.

Am J Physiol Heart Circ Physiol 2004 Dec;287(6):H2528-34

Dept. of Veterinary and Comparative Anatomy, Pharmacology, and Physiology, Washington State Univ., Pullman, WA 99164, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajpheart.00553.2004DOI Listing
December 2004

Novel gene locus for autosomal dominant left ventricular noncompaction maps to chromosome 11p15.

Circulation 2004 Jun 1;109(22):2720-3. Epub 2004 Jun 1.

Max Delbrück Center for Molecular Medicine, Robert-Roessle Str 10, 13092 Berlin, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/01.CIR.0000131865.21260.56DOI Listing
June 2004