Publications by authors named "Brenda Gerull"

51Publications

Cardiomyocyte adhesion and hyperadhesion differentially require ERK1/2 and plakoglobin.

JCI Insight 2020 Sep 17;5(18). Epub 2020 Sep 17.

Faculty of Medicine, Ludwig-Maximilians-University Munich, Munich, Germany.

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http://dx.doi.org/10.1172/jci.insight.140066DOI Listing
September 2020

Genetic Animal Models for Arrhythmogenic Cardiomyopathy.

Front Physiol 2020 24;11:624. Epub 2020 Jun 24.

Erich and Hanna Klessmann Institute for Cardiovascular Research and Development, Heart and Diabetes Center NRW, University Hospitals of the Ruhr-University of Bochum, Bad Oeynhausen, Germany.

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http://dx.doi.org/10.3389/fphys.2020.00624DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327121PMC
June 2020

New Insights on Genetic Diagnostics in Cardiomyopathy and Arrhythmia Patients Gained by Stepwise Exome Data Analysis.

J Clin Med 2020 Jul 9;9(7). Epub 2020 Jul 9.

Department of Cardiovascular Genetics, Comprehensive Heart Failure Center (CHFC) and Department of Medicine I, University Clinic Würzburg, 97078 Würzburg, Germany.

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http://dx.doi.org/10.3390/jcm9072168DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408654PMC
July 2020

Generation of two patient-derived iPSC lines from siblings (LIBUCi001-A and LIBUCi002-A) and a genetically modified iPSC line (JMUi001-A-1) to mimic dilated cardiomyopathy with ataxia (DCMA) caused by a homozygous DNAJC19 mutation.

Stem Cell Res 2020 07 2;46:101856. Epub 2020 Jun 2.

Comprehensive Heart Failure Center (CHFC) and Department of Internal Medicine I, University Hospital Würzburg, Würzburg, Germany; Libin Cardiovascular Institute of Alberta, Department of Cardiac Sciences, University of Calgary, Calgary, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.scr.2020.101856DOI Listing
July 2020

A homozygous DSC2 deletion associated with arrhythmogenic cardiomyopathy is caused by uniparental isodisomy.

J Mol Cell Cardiol 2020 04 19;141:17-29. Epub 2020 Mar 19.

Erich and Hanna Klessmann Institute for Cardiovascular Research & Development (EHKI), Heart and Diabetes Center NRW, University Hospital of the Ruhr-University Bochum, Georgstrasse 11, 32545 Bad Oeynhausen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.yjmcc.2020.03.006DOI Listing
April 2020

Restrictive Cardiomyopathy is Caused by a Novel Homozygous Desmin () Mutation p.Y122H Leading to a Severe Filament Assembly Defect.

Genes (Basel) 2019 11 11;10(11). Epub 2019 Nov 11.

Erich and Hanna Klessmann Institute for Cardiovascular Research & Development (EHKI), Heart and Diabetes Center NRW, University Hospital of the Ruhr-University Bochum. Georgstrasse 11, D-32545 Bad Oeynhausen, Germany.

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http://dx.doi.org/10.3390/genes10110918DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6896098PMC
November 2019

Targeted panel sequencing in pediatric primary cardiomyopathy supports a critical role of TNNI3.

Clin Genet 2019 12 22;96(6):549-559. Epub 2019 Oct 22.

Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Experimental and Clinical Research Center (ECRC), a joint cooperation between the Charité Medical Faculty and the Max-Delbrück-Center for Molecular Medicine (MDC), Berlin, Germany.

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http://dx.doi.org/10.1111/cge.13645DOI Listing
December 2019

The Pore-Lipid Interface: Role of Amino-Acid Determinants of Lipophilic Access by Ivabradine to the hERG1 Pore Domain.

Mol Pharmacol 2019 08 10;96(2):259-271. Epub 2019 Jun 10.

Centre for Molecular Simulation, Department of Biological Sciences, University of Calgary, Calgary, Alberta, Canada (L.P., M.K., S.Y.N.); Libin Cardiovascular Institute of Alberta (J.G., J.-L.M., H.J.D.) and Snyder Institute for Chronic Diseases (D.A.M.), Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada; Institute of Solution Chemistry, Russian Academy of Sciences, Ivanovo, Russian Federation (M.O., A.S., G.L.P.); Department of Cardiac Sciences and Libin Cardiovascular Institute of Alberta, University of Calgary, Calgary, Alberta, Canada (B.G.); and Comprehensive Heart Failure Center and Department of Internal Medicine I, University Hospital Würzburg, Würzburg, Germany (B.G.)

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http://dx.doi.org/10.1124/mol.118.115642DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6666383PMC
August 2019

Characterization of a Unique Form of Arrhythmic Cardiomyopathy Caused by Recessive Mutation in LEMD2.

JACC Basic Transl Sci 2019 Apr 29;4(2):204-221. Epub 2019 Apr 29.

Department of Cardiac Sciences, Libin Cardiovascular Institute of Alberta, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.

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http://dx.doi.org/10.1016/j.jacbts.2018.12.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6488817PMC
April 2019

Biallelic mutation in MYH7 and MYBPC3 leads to severe cardiomyopathy with left ventricular noncompaction phenotype.

Hum Mutat 2019 08 24;40(8):1101-1114. Epub 2019 Apr 24.

Comprehensive Heart Failure Center (CHFC) and Department of Medicine I, University and University Hospital Würzburg, Würzburg, Germany.

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http://dx.doi.org/10.1002/humu.23757DOI Listing
August 2019

Mutations in ILK, encoding integrin-linked kinase, are associated with arrhythmogenic cardiomyopathy.

Transl Res 2019 06 15;208:15-29. Epub 2019 Feb 15.

Department of Cardiac Sciences, Libin Cardiovascular Institute of Alberta, University of Calgary, Calgary, Alberta, Canada; Comprehensive Heart Failure Center and Department of Internal Medicine I, University Hospital Würzburg, Würzburg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.trsl.2019.02.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7412573PMC
June 2019

Genetic Association Study in Multigenerational Kindreds With Vasovagal Syncope: Evidence for Involvement of Sex-Specific Serotonin Signaling.

Circ Arrhythm Electrophysiol 2019 01;12(1):e006884

Libin Cardiovascular Institute of Calgary, Alberta, Canada (R.S., M.S.R., D.R., K.M., C.M., J.J., B.G.).

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http://dx.doi.org/10.1161/CIRCEP.118.006884DOI Listing
January 2019

Between Disease-Causing and an Innocent Bystander: The Role of Titin as a Modifier in Hypertrophic Cardiomyopathy.

Authors:
Brenda Gerull

Can J Cardiol 2017 10 21;33(10):1217-1220. Epub 2017 Jul 21.

Comprehensive Heart Failure Center and Department of Internal Medicine I, University Hospital Würzburg, Würzburg, Germany; Department of Cardiac Sciences and Libin Cardiovascular Institute of Alberta, University of Calgary, Calgary, Alberta, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cjca.2017.07.010DOI Listing
October 2017

Reversible Dilated Cardiomyopathy Caused by a High Burden of Ventricular Arrhythmias in Andersen-Tawil Syndrome.

Can J Cardiol 2016 12 27;32(12):1576.e15-1576.e18. Epub 2016 Jul 27.

Department of Cardiac Sciences and Libin Cardiovascular Institute of Alberta, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada; Department of Medical Genetics, University of Calgary and Alberta Health Services, Calgary, Alberta, Canada; Comprehensive Heart Failure Center and Department of Medicine I, University Hospital Würzburg, Würzburg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.cjca.2016.07.587DOI Listing
December 2016

Outcome of Apparently Unexplained Cardiac Arrest: Results From Investigation and Follow-Up of the Prospective Cardiac Arrest Survivors With Preserved Ejection Fraction Registry.

Circ Arrhythm Electrophysiol 2016 Jan;9(1):e003619

From the Division of Cardiology, Department of Medicine, University of British Columbia, Vancouver, BC, Canada (A.R.M.H., C.C., K.G., M.T.B., C.S., M.J., S.C., A.D.K.); Department of Cardiovascular Sciences, Libin Cardiovascular Institute, University of Calgary, Calgary, AB, Canada (B.G.); Division of Cardiology, Department of Medicine, Queen's University, Kingston, ON, Canada (C.S.S.); University of Ottawa Heart Institute, Ottawa, ON, Canada (D.H.B.); Division of Cardiology, Department of Medicine, Western University, London, ON, Canada (G.J.K., R.Y.); Department of Medicine, Quebec Heart and Lung Institute, Quebec City, QC, Canada (J.C.); Division of Cardiology, Department of Medicine, Population Health Research Institute, Hamilton, ON, Canada (J.S.H.); Department of Medicine, Montreal Heart Institute, Université de Montréal, Montreal, QC, Canada (M.T.); Division of Cardiology, Department of Medicine, QEII Health Sciences Center, Halifax, NS, Canada (M.G.); Division of Cardiology, Department of Medicine, University Health Network, Toronto, ON, Canada (M.H.G., V.S.C.); Division of Cardiology, Department of Medicine, St. Michael's Hospital, University of Toronto, Toronto, ON, Canada (P.A.); Division of Cardiology, Department of Medicine, Royal Jubilee Hospital, Victoria, BC, Canada (R.L.); and Division of Cardiology, Department of Pediatrics, BC Children's Hospital, Vancouver, BC, Canada (S.S.).

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http://dx.doi.org/10.1161/CIRCEP.115.003619DOI Listing
January 2016

Functional characterization of the novel DES mutation p.L136P associated with dilated cardiomyopathy reveals a dominant filament assembly defect.

J Mol Cell Cardiol 2016 Feb 23;91:207-14. Epub 2015 Dec 23.

Erich and Hanna Klessmann Institute for Cardiovascular Research & Development (EHKI), Heart and Diabetes Center NRW, Ruhr University Bochum, D-32545 Bad Oeynhausen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.yjmcc.2015.12.015DOI Listing
February 2016

Mutations in FLNC are Associated with Familial Restrictive Cardiomyopathy.

Hum Mutat 2016 Mar 8;37(3):269-79. Epub 2016 Jan 8.

Department of Cardiac Sciences, Libin Cardiovascular Institute of Alberta, University of Calgary, Calgary, Alberta, Canada.

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http://dx.doi.org/10.1002/humu.22942DOI Listing
March 2016

The Rapidly Evolving Role of Titin in Cardiac Physiology and Cardiomyopathy.

Authors:
Brenda Gerull

Can J Cardiol 2015 Nov 28;31(11):1351-9. Epub 2015 Aug 28.

Department of Cardiac Sciences, Libin Cardiovascular Institute of Alberta, University of Calgary, Calgary, Alberta, Canada; Department of Medical Genetics, University of Calgary and Alberta Health Services, Calgary, Alberta, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.cjca.2015.08.016DOI Listing
November 2015

Early repolarization syndrome: A case report focusing on dynamic electrocardiographic changes before ventricular arrhythmias and genetic analysis.

HeartRhythm Case Rep 2015 Jul 2;1(4):213-216. Epub 2015 Apr 2.

Department of Cardiac Sciences, Libin Cardiovascular Institute of Alberta, University of Calgary, Alberta, Canada.

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http://dx.doi.org/10.1016/j.hrcr.2015.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5419330PMC
July 2015

Phenotypic analysis of arrhythmogenic cardiomyopathy in the Hutterite population: role of electrocardiogram in identifying high-risk desmocollin-2 carriers.

J Am Heart Assoc 2014 Dec 11;3(6):e001407. Epub 2014 Dec 11.

Libin Cardiovascular Institute of Alberta & Department of Cardiac Sciences, University of Calgary, Alberta, Canada (J.A.W., H.J.D., T.Y., L.K., D.V.E., S.G.W., B.G.).

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http://dx.doi.org/10.1161/JAHA.114.001407DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338736PMC
December 2014

Congenital long QT syndrome: severe torsades de pointes provoked by epinephrine in a digenic mutation carrier.

Heart Lung 2014 Nov-Dec;43(6):541-5. Epub 2014 Sep 16.

Department of Cardiac Sciences, Libin Cardiovascular Institute of Alberta, University of Calgary, Calgary, AB, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.hrtlng.2014.07.004DOI Listing
June 2015

Skin-heart connection: what can the epidermis tell us about the myocardium in arrhythmogenic cardiomyopathy?

Authors:
Brenda Gerull

Circ Cardiovasc Genet 2014 Jun;7(3):225-7

From the Department of Cardiac Sciences, Libin Cardiovascular Institute of Alberta, University of Calgary, Calgary, Alberta, Canada.

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http://dx.doi.org/10.1161/CIRCGENETICS.114.000647DOI Listing
June 2014

Exome sequencing identifies a novel variant in ACTC1 associated with familial atrial septal defect.

Can J Cardiol 2014 Feb 6;30(2):181-7. Epub 2013 Dec 6.

Department of Cardiac Sciences, University of Calgary and Libin Cardiovascular Institute of Alberta, Calgary, Alberta, Canada; Department of Medical Genetics, University of Calgary, Calgary, Alberta, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0828282X130171
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http://dx.doi.org/10.1016/j.cjca.2013.12.003DOI Listing
February 2014

Titin mutation in familial restrictive cardiomyopathy.

Int J Cardiol 2014 Jan 25;171(1):24-30. Epub 2013 Nov 25.

Heart Failure Service and Heart Institute, Tel Aviv University, Tel Aviv, Israel. Electronic address:

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http://dx.doi.org/10.1016/j.ijcard.2013.11.037DOI Listing
January 2014

Homozygous founder mutation in desmocollin-2 (DSC2) causes arrhythmogenic cardiomyopathy in the Hutterite population.

Circ Cardiovasc Genet 2013 Aug 17;6(4):327-36. Epub 2013 Jul 17.

Department of Cardiac Sciences, Libin Cardiovascular Institute of Alberta, Calgary, AB, Canada.

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http://dx.doi.org/10.1161/CIRCGENETICS.113.000097DOI Listing
August 2013

A novel titin mutation in adult-onset familial dilated cardiomyopathy.

Am J Cardiol 2012 Jun 3;109(11):1644-50. Epub 2012 Apr 3.

Heart Failure Service and Heart Institute, Sheba Medical Center, Tel Hashomer, Tel Aviv University, Tel Aviv, Israel.

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http://dx.doi.org/10.1016/j.amjcard.2012.01.392DOI Listing
June 2012

Novel c.367_369del LMNA mutation manifesting as severe arrhythmias, dilated cardiomyopathy, and myopathy.

Heart Lung 2012 Jul-Aug;41(4):382-6. Epub 2011 Oct 21.

Second Medical Department, Krankenanstalt Rudolfstiftung, Vienna, Austria.

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http://dx.doi.org/10.1016/j.hrtlng.2011.07.007DOI Listing
November 2012

Mutant desmocollin-2 causes arrhythmogenic right ventricular cardiomyopathy.

Am J Hum Genet 2006 Dec 3;79(6):1081-8. Epub 2006 Oct 3.

Max-Delbrueck Center for Molecular Medicine, Franz-Volhard Clinic, HELIOS Clinics GmbH, Charité, Humboldt University, Berlin, Germany.

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http://dx.doi.org/10.1086/509044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1698714PMC
December 2006

Identification of a novel frameshift mutation in the giant muscle filament titin in a large Australian family with dilated cardiomyopathy.

J Mol Med (Berl) 2006 Jun 6;84(6):478-83. Epub 2006 May 6.

Max-Delbrueck Center for Molecular Medicine, Robert-Roessle-Str. 10, 13092, Berlin-Buch, Germany.

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http://dx.doi.org/10.1007/s00109-006-0060-6DOI Listing
June 2006

Titin isoform-dependent effect of calcium on passive myocardial tension.

Am J Physiol Heart Circ Physiol 2004 Dec;287(6):H2528-34

Dept. of Veterinary and Comparative Anatomy, Pharmacology, and Physiology, Washington State Univ., Pullman, WA 99164, USA.

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http://dx.doi.org/10.1152/ajpheart.00553.2004DOI Listing
December 2004

Novel gene locus for autosomal dominant left ventricular noncompaction maps to chromosome 11p15.

Circulation 2004 Jun 1;109(22):2720-3. Epub 2004 Jun 1.

Max Delbrück Center for Molecular Medicine, Robert-Roessle Str 10, 13092 Berlin, Germany.

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http://dx.doi.org/10.1161/01.CIR.0000131865.21260.56DOI Listing
June 2004