Bradley D Anderson

Bradley D Anderson

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Bradley D Anderson

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Frenolicin B Targets Peroxiredoxin 1 and Glutaredoxin 3 to Trigger ROS/4E-BP1-Mediated Antitumor Effects.

Cell Chem Biol 2019 03 17;26(3):366-377.e12. Epub 2019 Jan 17.

Department of Pharmacology and Nutritional Sciences, College of Medicine, University of Kentucky, Lexington, KY 40536, USA; Markey Cancer Center, University of Kentucky, Lexington, KY 40536, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2018.11.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6557261PMC
March 2019

Effects of Molecular Interactions on Miscibility and Mobility of Ibuprofen in Amorphous Solid Dispersions With Various Polymers.

J Pharm Sci 2019 Jan 3;108(1):178-186. Epub 2018 Nov 3.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00223549183068
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http://dx.doi.org/10.1016/j.xphs.2018.10.052DOI Listing
January 2019

Predicting Solubility/Miscibility in Amorphous Dispersions: It Is Time to Move Beyond Regular Solution Theories.

J Pharm Sci 2018 01 12;107(1):24-33. Epub 2017 Oct 12.

Department of Pharmaceutical Sciences, University of Kentucky, Lexington, Kentucky 40506. Electronic address:

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http://dx.doi.org/10.1016/j.xphs.2017.09.030DOI Listing
January 2018

Equilibrium solubility measurement of compounds with low dissolution rate by Higuchi's Facilitated Dissolution Method. A validation study.

Eur J Pharm Sci 2017 Aug 31;106:133-141. Epub 2017 May 31.

in-ADME Research, 1732 First Avenue, #102, New York, NY 10128, USA.

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http://dx.doi.org/10.1016/j.ejps.2017.05.064DOI Listing
August 2017

Ion-Pairing Contribution to the Liposomal Transport of Topotecan as Revealed by Mechanistic Modeling.

J Pharm Sci 2017 04 20;106(4):1149-1161. Epub 2016 Dec 20.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536. Electronic address:

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http://dx.doi.org/10.1016/j.xphs.2016.12.011DOI Listing
April 2017

Molecular Dynamics Simulation of Amorphous Hydroxypropylmethylcellulose and Its Mixtures With Felodipine and Water.

J Pharm Sci 2017 03 13;106(3):803-816. Epub 2016 Dec 13.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536. Electronic address:

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http://dx.doi.org/10.1016/j.xphs.2016.10.026DOI Listing
March 2017

Hydrogen Bonding Interactions in Amorphous Indomethacin and Its Amorphous Solid Dispersions with Poly(vinylpyrrolidone) and Poly(vinylpyrrolidone-co-vinyl acetate) Studied Using (13)C Solid-State NMR.

Mol Pharm 2015 Dec 12;12(12):4518-28. Epub 2015 Nov 12.

College of Pharmacy, University of Kentucky , 789 South Limestone Street, Lexington, Kentucky 40536, United States.

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http://dx.doi.org/10.1021/acs.molpharmaceut.5b00705DOI Listing
December 2015

Mechanistic model and analysis of doxorubicin release from liposomal formulations.

J Control Release 2015 Nov 23;217:82-91. Epub 2015 Aug 23.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536, US. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01683659153006
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http://dx.doi.org/10.1016/j.jconrel.2015.08.024DOI Listing
November 2015

Adsorption of Polyvinylpyrrolidone and its Impact on Maintenance of Aqueous Supersaturation of Indomethacin via Crystal Growth Inhibition.

J Pharm Sci 2015 Sep 2;104(9):2923-33. Epub 2015 Jun 2.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky, 40506.

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http://dx.doi.org/10.1002/jps.24493DOI Listing
September 2015

Release, partitioning, and conjugation stability of doxorubicin in polymer micelles determined by mechanistic modeling.

Pharm Res 2015 May 19;32(5):1752-63. Epub 2014 Nov 19.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 South Limestone, Lexington, Kentucky, 40536-0596, USA.

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http://link.springer.com/content/pdf/10.1007/s11095-014-1573
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http://link.springer.com/10.1007/s11095-014-1573-2
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http://dx.doi.org/10.1007/s11095-014-1573-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4382418PMC
May 2015

Determination of key parameters for a mechanism-based model to predict Doxorubicin release from actively loaded liposomes.

J Pharm Sci 2015 Mar 5;104(3):1087-98. Epub 2015 Jan 5.

Department of Natural Sciences and Mathematics, Transylvania University, Lexington, Kentucky, 40508.

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http://dx.doi.org/10.1002/jps.24307DOI Listing
March 2015

Insights into accelerated liposomal release of topotecan in plasma monitored by a non-invasive fluorescence spectroscopic method.

J Control Release 2015 Jan 25;197:10-9. Epub 2014 Oct 25.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jconrel.2014.10.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4356028PMC
January 2015

Water uptake, distribution, and mobility in amorphous poly(D,L-lactide) by molecular dynamics simulation.

J Pharm Sci 2014 Sep 22;103(9):2759-2771. Epub 2014 Jan 22.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536. Electronic address:

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http://dx.doi.org/10.1002/jps.23855DOI Listing
September 2014

Molecular dynamics simulation of amorphous hydroxypropyl-methylcellulose acetate succinate (HPMCAS): polymer model development, water distribution, and plasticization.

Mol Pharm 2014 Jul 19;11(7):2400-11. Epub 2014 Jun 19.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky , Lexington, Kentucky 40536, United States.

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http://dx.doi.org/10.1021/mp500135fDOI Listing
July 2014

Effect of precipitation inhibitors on indomethacin supersaturation maintenance: mechanisms and modeling.

Mol Pharm 2014 May 7;11(5):1489-99. Epub 2014 Apr 7.

Department of Pharmaceutical Sciences College of Pharmacy Universiy of Kentucky Lexington, Kentucky 40506, United States.

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http://dx.doi.org/10.1021/mp400658kDOI Listing
May 2014

Dynamic, nonsink method for the simultaneous determination of drug permeability and binding coefficients in liposomes.

Mol Pharm 2014 Apr 28;11(4):1314-25. Epub 2014 Mar 28.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky , A323A ASTeCC Building, Lexington, Kentucky 40506, United States.

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http://dx.doi.org/10.1021/mp400765nDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3993891PMC
April 2014

The role of pH and ring-opening hydrolysis kinetics on liposomal release of topotecan.

J Control Release 2014 Jan 12;174:88-97. Epub 2013 Nov 12.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40506, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jconrel.2013.11.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4104781PMC
January 2014

Bilayer composition, temperature, speciation effects and the role of bilayer chain ordering on partitioning of dexamethasone and its 21-phosphate.

Pharm Res 2013 Dec 25;30(12):3154-69. Epub 2013 Jul 25.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, A323A ASTeCC Bldg., Lexington, Kentucky, 40506, USA.

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http://link.springer.com/10.1007/s11095-013-1143-z
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http://dx.doi.org/10.1007/s11095-013-1143-zDOI Listing
December 2013

Determination of drug release kinetics from nanoparticles: overcoming pitfalls of the dynamic dialysis method.

Mol Pharm 2013 Aug 28;10(8):3076-89. Epub 2013 Jun 28.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky , Lexington, Kentucky 40506, United States.

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http://dx.doi.org/10.1021/mp400154aDOI Listing
August 2013

Maintenance of supersaturation II: indomethacin crystal growth kinetics versus degree of supersaturation.

J Pharm Sci 2013 May 11;102(5):1544-53. Epub 2013 Mar 11.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40506, USA.

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http://dx.doi.org/10.1002/jps.23498DOI Listing
May 2013

Molecular dynamics simulation of amorphous indomethacin-poly(vinylpyrrolidone) glasses: solubility and hydrogen bonding interactions.

J Pharm Sci 2013 Mar 20;102(3):876-91. Epub 2012 Dec 20.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536, USA.

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http://dx.doi.org/10.1002/jps.23353DOI Listing
March 2013

Molecular dynamics simulation of amorphous indomethacin.

Mol Pharm 2013 Jan 29;10(1):102-14. Epub 2012 Nov 29.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536, United States.

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http://www.cpd.gatech.edu/sites/default/files/2014%20CPD%20P
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http://pubs.acs.org/doi/abs/10.1021/mp3000698
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http://dx.doi.org/10.1021/mp3000698DOI Listing
January 2013

Quantification of trans-2,6-difluoro-4'-N,N-dimethylaminostilbene in rat plasma: application to a pharmacokinetic study.

J Pharm Biomed Anal 2013 Jan 4;72:115-20. Epub 2012 Oct 4.

Department of Pharmacy, National University of Singapore, 10 Kent Ridge Crescent, Singapore 119260, Singapore.

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http://dx.doi.org/10.1016/j.jpba.2012.09.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3731135PMC
January 2013

Kinetics and mechanisms of deamidation and covalent amide-linked adduct formation in amorphous lyophiles of a model asparagine-containing Peptide.

Pharm Res 2012 Oct 18;29(10):2722-37. Epub 2011 Oct 18.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, A323A ASTeCC Bldg., Lexington, Kentucky, 40536-0082, USA.

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http://dx.doi.org/10.1007/s11095-011-0591-6DOI Listing
October 2012

A mechanism-based kinetic analysis of succinimide-mediated deamidation, racemization, and covalent adduct formation in a model peptide in amorphous lyophiles.

J Pharm Sci 2012 Sep 23;101(9):3096-109. Epub 2012 Jan 23.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536-0082, USA.

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http://dx.doi.org/10.1002/jps.23061DOI Listing
September 2012

Effects of water and polymer content on covalent amide-linked adduct formation in peptide-containing amorphous lyophiles.

J Pharm Sci 2012 Sep 21;101(9):3142-56. Epub 2012 Mar 21.

Catalent Pharma Solutions, 1100 Enterprise Drive, Winchester, Kentucky 40391, USA.

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http://dx.doi.org/10.1002/jps.23092DOI Listing
September 2012

Enhanced active liposomal loading of a poorly soluble ionizable drug using supersaturated drug solutions.

J Control Release 2012 Sep 16;162(2):330-9. Epub 2012 Jul 16.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40506, USA.

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http://dx.doi.org/10.1016/j.jconrel.2012.07.001DOI Listing
September 2012

Pharmacokinetic modeling to assess factors affecting the oral bioavailability of the lactone and carboxylate forms of the lipophilic camptothecin analogue AR-67 in rats.

Pharm Res 2012 Jul 9;29(7):1722-36. Epub 2011 Nov 9.

Department of Pharmaceutical Sciences, University of Kentucky, Lexington, Kentucky 40536, USA.

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http://link.springer.com/10.1007/s11095-011-0617-0
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http://dx.doi.org/10.1007/s11095-011-0617-0DOI Listing
July 2012

An atomic and molecular view of the depth dependence of the free energies of solute transfer from water into lipid bilayers.

Mol Pharm 2011 Dec 8;8(6):2204-15. Epub 2011 Nov 8.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40506, United States.

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http://dx.doi.org/10.1021/mp2000204DOI Listing
December 2011

Maintenance of supersaturation I: indomethacin crystal growth kinetic modeling using an online second-derivative ultraviolet spectroscopic method.

J Pharm Sci 2011 Jul 21;100(7):2623-41. Epub 2011 Jan 21.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40506, USA.

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http://dx.doi.org/10.1002/jps.22478DOI Listing
July 2011

Functional group dependence of solute partitioning to various locations within a DOPC bilayer: a comparison of molecular dynamics simulations with experiment.

J Pharm Sci 2011 Jun 6;100(6):2136-46. Epub 2011 Jan 6.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40506, USA.

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http://dx.doi.org/10.1002/jps.22441DOI Listing
June 2011

Factors affecting the in vivo lactone stability and systemic clearance of the lipophilic camptothecin analogue AR-67.

Pharm Res 2010 Jul 29;27(7):1416-25. Epub 2010 Apr 29.

Department of Pharmaceutical Sciences, University of Kentucky, Lexington, Kentucky 40536, USA.

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http://link.springer.com/content/pdf/10.1007%2Fs11095-010-01
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http://link.springer.com/10.1007/s11095-010-0137-3
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http://dx.doi.org/10.1007/s11095-010-0137-3DOI Listing
July 2010

Substituent effects on the ionization and partitioning of p-(aminoethyl)phenols and structurally related compounds: electrostatic effects dependent on conformation.

J Pharm Sci 2009 Dec;98(12):4534-44

Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, A323 ASTeCC Building, Lexington, Kentucky 40506, USA.

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http://dx.doi.org/10.1002/jps.21775DOI Listing
December 2009

Molecular dynamics simulations of functional group effects on solvation thermodynamics of model solutes in decane and tricaprylin.

Mol Pharm 2008 Nov-Dec;5(6):1023-36

Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536, USA.

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http://dx.doi.org/10.1021/mp8000606DOI Listing
June 2009

Effect of cyclodextrin complexation on the liposome permeability of a model hydrophobic weak Acid.

Pharm Res 2008 Nov 19;25(11):2505-15. Epub 2008 Jul 19.

Department of Pharmaceutical Sciences, University of Kentucky, A323A ASTeCC Bldg., Lexington, Kentucky 40536-0082, USA.

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http://dx.doi.org/10.1007/s11095-008-9664-6DOI Listing
November 2008

Development of structure-lipid bilayer permeability relationships for peptide-like small organic molecules.

Mol Pharm 2008 May-Jun;5(3):371-88. Epub 2008 Mar 21.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536, USA.

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http://dx.doi.org/10.1021/mp700100nDOI Listing
August 2008

Quantitative solubility relationships and the effect of water uptake in triglyceride/monoglyceride microemulsions.

Pharm Res 2008 May 19;25(5):1158-74. Epub 2007 Dec 19.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, A323A, ASTeCC Building, Lexington, KY 40536, USA.

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http://dx.doi.org/10.1007/s11095-007-9500-4DOI Listing
May 2008

Determination of intraliposomal pH and its effect on membrane partitioning and passive loading of a hydrophobic camptothecin, DB-67.

Int J Pharm 2008 Mar 12;352(1-2):17-28. Epub 2007 Oct 12.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40506, United States.

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http://dx.doi.org/10.1016/j.ijpharm.2007.10.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2277365PMC
March 2008

What determines drug solubility in lipid vehicles: is it predictable?

Adv Drug Deliv Rev 2008 Mar 7;60(6):638-56. Epub 2007 Nov 7.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40506, USA.

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http://dx.doi.org/10.1016/j.addr.2007.10.015DOI Listing
March 2008

Influence of intravesicular pH drift and membrane binding on the liposomal release of a model amine-containing permeant.

J Pharm Sci 2008 Jan;97(1):381-99

Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40506, USA.

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http://dx.doi.org/10.1002/jps.21108DOI Listing
January 2008

Liposome transport of hydrophobic drugs: gel phase lipid bilayer permeability and partitioning of the lactone form of a hydrophobic camptothecin, DB-67.

J Pharm Sci 2008 Jan;97(1):400-20

Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40506, USA.

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http://dx.doi.org/10.1002/jps.21125DOI Listing
January 2008

Liposomal delivery of hydrophobic weak acids: enhancement of drug retention using a high intraliposomal pH.

J Pharm Sci 2008 Jan;97(1):433-54

Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40506, USA.

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http://dx.doi.org/10.1002/jps.21135DOI Listing
January 2008

The role of the cyclic imide in alternate degradation pathways for asparagine-containing peptides and proteins.

J Pharm Sci 2007 Oct;96(10):2667-85

Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40506.

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http://linkinghub.elsevier.com/retrieve/pii/S002235491632370
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http://dx.doi.org/10.1002/jps.20905DOI Listing
October 2007

Inhibition of P-glycoprotein activity at the primate blood-brain barrier increases the distribution of nelfinavir into the brain but not into the cerebrospinal fluid.

Drug Metab Dispos 2007 Sep 25;35(9):1459-62. Epub 2007 Jun 25.

School of Pharmacy, Department of Pharmaceutics, University of Washington, Box 357610, Seattle, WA 98195, USA.

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http://dx.doi.org/10.1124/dmd.107.016220DOI Listing
September 2007

Molecular dynamics simulations and experimental studies of binding and mobility of 7-tert-butyldimethylsilyl-10-hydroxycamptothecin and its 20(S)-4-aminobutyrate ester in DMPC membranes.

Mol Pharm 2006 Sep-Oct;3(5):589-600

Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40506, USA.

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http://dx.doi.org/10.1021/mp0600081DOI Listing
January 2007

Validation of an HPLC method for analysis of DB-67 and its water soluble prodrug in mouse plasma.

J Chromatogr B Analyt Technol Biomed Life Sci 2006 Nov 21;844(1):15-22. Epub 2006 Jul 21.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536, USA.

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http://dx.doi.org/10.1016/j.jchromb.2006.06.022DOI Listing
November 2006

Liposomal drug transport: a molecular perspective from molecular dynamics simulations in lipid bilayers.

Adv Drug Deliv Rev 2006 Nov 22;58(12-13):1357-78. Epub 2006 Sep 22.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S0169409X0600168
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http://dx.doi.org/10.1016/j.addr.2006.09.002DOI Listing
November 2006

Kinetics and mechanism for the reaction of cysteine with hydrogen peroxide in amorphous polyvinylpyrrolidone lyophiles.

Pharm Res 2006 Oct 2;23(10):2239-53. Epub 2006 Sep 2.

Department of Pharmaceutical Sciences, University of Kentucky, ASTeCC Bldg., Room A323A, Lexington, Kentucky 40506, USA.

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http://dx.doi.org/10.1007/s11095-006-9052-zDOI Listing
October 2006

Synthesis and biological assays of E-ring analogs of camptothecin and homocamptothecin.

Bioorg Med Chem 2006 Sep 21;14(18):6202-12. Epub 2006 Jun 21.

Department of Chemistry, University of Pittsburgh, Pittsburgh, PA 15260, USA.

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http://dx.doi.org/10.1016/j.bmc.2006.05.073DOI Listing
September 2006

Kinetics and mechanisms of activation of alpha-amino acid ester prodrugs of camptothecins.

J Med Chem 2006 Jul;49(14):4344-55

Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, 40536-0082, USA.

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http://dx.doi.org/10.1021/jm060016lDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2516925PMC
July 2006

Conformational structure, dynamics, and solvation energies of small alanine peptides in water and carbon tetrachloride.

J Pharm Sci 2006 Jun;95(6):1269-87

Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536, USA.

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http://dx.doi.org/10.1002/jps.20453DOI Listing
June 2006

Dependence of nelfinavir brain uptake on dose and tissue concentrations of the selective P-glycoprotein inhibitor zosuquidar in rats.

Drug Metab Dispos 2006 Apr 24;34(4):653-9. Epub 2006 Jan 24.

University of Kentucky, Department of Pharmaceutical Sciences, ASTeCC Bldg, Room A323A, Lexington, KY 40506-0286, USA.

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http://dx.doi.org/10.1124/dmd.105.006536DOI Listing
April 2006

Application of an exact mathematical model and the steady-state approximation to the kinetics of the reaction of cysteine and hydrogen peroxide in aqueous solution: a reply to the Ashby and Nagy commentary.

J Pharm Sci 2006 Jan;95(1):19-24

Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, USA.

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http://dx.doi.org/10.1002/jps.20539DOI Listing
January 2006

Distribution and effect of water content on molecular mobility in poly(vinylpyrrolidone) glasses: a molecular dynamics simulation.

Pharm Res 2005 Aug 3;22(8):1205-14. Epub 2005 Aug 3.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536, USA.

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http://dx.doi.org/10.1007/s11095-005-5277-5DOI Listing
August 2005

Kinetics and mechanism of the reaction of cysteine and hydrogen peroxide in aqueous solution.

J Pharm Sci 2005 Feb;94(2):304-16

Department of Pharmaceutical Sciences, University of Kentucky, Lexington, Kentucky 40506, USA.

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http://dx.doi.org/10.1002/jps.20253DOI Listing
February 2005

Predictive relationships for the effects of triglyceride ester concentration and water uptake on solubility and partitioning of small molecules into lipid vehicles.

J Pharm Sci 2004 Nov;93(11):2768-79

Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536, USA.

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http://dx.doi.org/10.1002/jps.20126DOI Listing
November 2004

HIV in central nervous system and behavioral development: an HIV-2287 macaque model of AIDS.

AIDS 2004 Jul;18(10):1363-70

Department of Pharmaceutics and Washington National Primate Research Center, University of Washington, Seattle Washington 98195-7610, USA.

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http://dx.doi.org/10.1097/01.aids.0000131307.62828.a1DOI Listing
July 2004

A molecular dynamics simulation of reactant mobility in an amorphous formulation of a peptide in poly(vinylpyrrolidone).

J Pharm Sci 2004 Apr;93(4):855-76

Division of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536, USA.

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http://dx.doi.org/10.1002/jps.20004DOI Listing
April 2004

Determination of carrier-mediated transport of 2',3'-dideoxypurine nucleosides in the rat ileum using a bidirectional perfusion technique.

Pharm Res 2004 Feb;21(2):300-8

Division of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40506, USA.

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http://dx.doi.org/10.1023/b:pham.0000016243.73161.88DOI Listing
February 2004

Epimer interconversion, isomerization, and hydrolysis of tetrahydrouridine: implications for cytidine deaminase inhibition.

J Pharm Sci 2003 Oct;92(10):2027-39

Division of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536, USA.

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http://dx.doi.org/10.1002/jps.10447DOI Listing
October 2003

A hydrophobicity scale for the lipid bilayer barrier domain from peptide permeabilities: nonadditivities in residue contributions.

Biochemistry 2003 Feb;42(6):1624-36

Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, Utah 84108, USA.

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http://dx.doi.org/10.1021/bi026701lDOI Listing
February 2003

Stable supersaturated aqueous solutions of silatecan 7-t-butyldimethylsilyl-10-hydroxycamptothecin via chemical conversion in the presence of a chemically modified beta-cyclodextrin.

Pharm Res 2002 Aug;19(8):1215-22

Division of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington 40536-0082, USA.

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http://dx.doi.org/10.1023/a:1019862629357DOI Listing
August 2002

Effects of a P-glycoprotein inhibitor on brain and plasma concentrations of anti-human immunodeficiency virus drugs administered in combination in rats.

Drug Metab Dispos 2002 May;30(5):479-82

Division of Pharmaceutical Sciences, University of Kentucky, Lexington, Kentucky 40536-0082, USA.

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http://dx.doi.org/10.1124/dmd.30.5.479DOI Listing
May 2002

A computer simulation of functional group contributions to free energy in water and a DPPC lipid bilayer.

Biophys J 2002 Apr;82(4):2052-66

Division of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky 40536, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1302000PMC
http://dx.doi.org/10.1016/S0006-3495(02)75553-7DOI Listing
April 2002

Transport across 1,9-decadiene precisely mimics the chemical selectivity of the barrier domain in egg lecithin bilayers.

J Pharm Sci 2002 Mar;91(3):640-6

Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, 421 Wakara Way Suite 418, Salt Lake City, UT 84108, USA.

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http://dx.doi.org/10.1002/jps.10067DOI Listing
March 2002

Investigation of the mechanism of enhancement of central nervous system delivery of 2'-beta-fluoro-2',3'-dideoxyinosine via a blood-brain barrier adenosine deaminase-activated prodrug.

Drug Metab Dispos 2002 Feb;30(2):191-8

Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, Utah, USA.

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http://dx.doi.org/10.1124/dmd.30.2.191DOI Listing
February 2002