Brad Spellberg

Brad Spellberg

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Brad Spellberg

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Sustainable Discovery and Development of Antibiotics - Is a Nonprofit Approach the Future?

N Engl J Med 2019 Aug 19;381(6):503-505. Epub 2019 Jun 19.

From the Stritch School of Medicine and the Parkinson School of Health Sciences and Public Health, Loyola University Chicago, Maywood, IL (T.B.N.); the David Geffen School of Medicine at the University of California, Los Angeles (E.P.B.) and the Los Angeles County and University of Southern California Medical Center (B.S.) - both in Los Angeles; the Providence Portland Medical Center and University of Oregon Health Sciences School of Medicine, Portland (D.N.G.); and the Johns Hopkins University School of Medicine, Baltimore (J.G.B.).

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http://dx.doi.org/10.1056/NEJMp1905589DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6697094PMC
August 2019

Adenosine Deaminase Diagnostic Testing in Pericardial Fluid.

JAMA 2019 07;322(2):163-164

Los Angeles County + University of Southern California (LAC+USC) Medical Center, Los Angeles, California.

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http://dx.doi.org/10.1001/jama.2019.7535DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6697089PMC
July 2019

Duration of Antibiotic Therapy: Shorter Is Better.

Ann Intern Med 2019 Jul 9. Epub 2019 Jul 9.

Rhode Island Hospital, Warren Alpert Medical School of Brown University, Providence, Rhode Island (L.B.R.).

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http://dx.doi.org/10.7326/M19-1509DOI Listing
July 2019

Natural history of Acinetobacter baumannii infection in mice.

PLoS One 2019 18;14(7):e0219824. Epub 2019 Jul 18.

Department of Medicine, Keck School of Medicine at the University of Southern California (USC), Los Angeles, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0219824PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6638954PMC
July 2019

Adjunctive transferrin to reduce the emergence of antibiotic resistance in Gram-negative bacteria.

J Antimicrob Chemother 2019 Jun 6. Epub 2019 Jun 6.

Department of Medicine, Keck School of Medicine at the University of Southern California (USC), Los Angeles, CA, USA.

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http://dx.doi.org/10.1093/jac/dkz225DOI Listing
June 2019

Publisher Correction: SERPINB1-mediated checkpoint of inflammatory caspase activation.

Nat Immunol 2019 May;20(5):664

Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

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http://dx.doi.org/10.1038/s41590-019-0361-xDOI Listing
May 2019

Reply to Author.

Clin Infect Dis 2019 May 9. Epub 2019 May 9.

Los Angeles County + University of Southern California (LAC+USC) Medical Center.

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http://dx.doi.org/10.1093/cid/ciz377DOI Listing
May 2019

Defining the Breakpoint Duration of Staphylococcus aureus Bacteremia Predictive of Poor Outcomes.

Clin Infect Dis 2019 Apr 5. Epub 2019 Apr 5.

Department of Clinical Pharmacy, University of Southern California (USC) School of Pharmacy, Los Angeles, USA.

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https://academic.oup.com/cid/advance-article/doi/10.1093/cid
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http://dx.doi.org/10.1093/cid/ciz257DOI Listing
April 2019

SERPINB1-mediated checkpoint of inflammatory caspase activation.

Nat Immunol 2019 03 28;20(3):276-287. Epub 2019 Jan 28.

Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

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http://dx.doi.org/10.1038/s41590-018-0303-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450391PMC
March 2019

Osteomyelitis Complicating Sacral Pressure Ulcers: Whether or Not to Treat With Antibiotic Therapy.

Clin Infect Dis 2019 Jan;68(2):338-342

Division of Infectious Diseases, Keck School of Medicine, University of Southern California (USC).

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http://dx.doi.org/10.1093/cid/ciy559DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6594415PMC
January 2019

Reply to Steigbigel and Steigbigel.

Clin Infect Dis 2019 Jan;68(2):352-353

Los Angeles County + University of Southern California (LAC+USC) Medical Center.

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https://academic.oup.com/cid/article/68/2/352/5067396
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http://dx.doi.org/10.1093/cid/ciy646DOI Listing
January 2019

Short Course Antibiotic Therapy-Replacing Constantine Units with "Shorter Is Better".

Clin Infect Dis 2019 Jan 7. Epub 2019 Jan 7.

Los Angeles County + University of Southern California (LAC+USC) Medical Center, Los Angeles, CA.

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http://dx.doi.org/10.1093/cid/ciy1134DOI Listing
January 2019

Expected Practice as a Novel Antibiotic Stewardship Intervention.

Open Forum Infect Dis 2019 Jan 3;6(1):ofy319. Epub 2018 Dec 3.

Los Angeles County + University of Southern California (USC) Medical Center, Los Angeles, CA.

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http://dx.doi.org/10.1093/ofid/ofy319DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324551PMC
January 2019

Procalcitonin-Guided Antibiotic Use.

N Engl J Med 2018 11;379(20):1972-3

Ridgewood Infectious Diseases Associates, Ridgewood, NJ

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http://www.nejm.org/doi/10.1056/NEJMc1811150
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http://dx.doi.org/10.1056/NEJMc1811150DOI Listing
November 2018

Lean methods to improve operating room elective first case on-time starts in a large, urban, safety net medical center.

Am J Surg 2018 08 24;216(2):194-201. Epub 2018 May 24.

Los Angeles County + University of Southern California (LAC+USC) Medical Center, Los Angeles, CA, USA; Department of Surgery, Keck School of Medicine of University of Southern California, Los Angeles, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.amjsurg.2018.05.002DOI Listing
August 2018

Reducing Clostridium difficile Colitis Rates Via Cost-Saving Diagnostic Stewardship.

Infect Control Hosp Epidemiol 2018 06 3;39(6):734-736. Epub 2018 Apr 3.

1Los Angeles County and University of Southern California Medical Center,Los Angeles,California.

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http://dx.doi.org/10.1017/ice.2018.51DOI Listing
June 2018

Murine Oropharyngeal Aspiration Model of Ventilator-associated and Hospital-acquired Bacterial Pneumonia.

J Vis Exp 2018 06 28(136). Epub 2018 Jun 28.

Department of Molecular Microbiology and Immunology, University of Southern California; Division of Infectious Diseases, Department of Medicine, LAC+USC Medical Center.

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http://dx.doi.org/10.3791/57672DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102004PMC
June 2018

Antimicrobials: a global alliance for optimizing their rational use in intra-abdominal infections (AGORA).

Authors:
Massimo Sartelli Dieter G Weber Etienne Ruppé Matteo Bassetti Brian J Wright Luca Ansaloni Fausto Catena Federico Coccolini Fikri M Abu-Zidan Raul Coimbra Ernest E Moore Frederick A Moore Ronald V Maier Jan J De Waele Andrew W Kirkpatrick Ewen A Griffiths Christian Eckmann Adrian J Brink John E Mazuski Addison K May Rob G Sawyer Dominik Mertz Philippe Montravers Anand Kumar Jason A Roberts Jean-Louis Vincent Richard R Watkins Warren Lowman Brad Spellberg Iain J Abbott Abdulrashid Kayode Adesunkanmi Sara Al-Dahir Majdi N Al-Hasan Ferdinando Agresta Asma A Althani Shamshul Ansari Rashid Ansumana Goran Augustin Miklosh Bala Zsolt J Balogh Oussama Baraket Aneel Bhangu Marcelo A Beltrán Michael Bernhard Walter L Biffl Marja A Boermeester Stephen M Brecher Jill R Cherry-Bukowiec Otmar R Buyne Miguel A Cainzos Kelly A Cairns Adrian Camacho-Ortiz Sujith J Chandy Asri Che Jusoh Alain Chichom-Mefire Caroline Colijn Francesco Corcione Yunfeng Cui Daniel Curcio Samir Delibegovic Zaza Demetrashvili Belinda De Simone Sameer Dhingra José J Diaz Isidoro Di Carlo Angel Dillip Salomone Di Saverio Michael P Doyle Gereltuya Dorj Agron Dogjani Hervé Dupont Soumitra R Eachempati Mushira Abdulaziz Enani Valery N Egiev Mutasim M Elmangory Paula Ferrada Joseph R Fitchett Gustavo P Fraga Nathalie Guessennd Helen Giamarellou Wagih Ghnnam George Gkiokas Staphanie R Goldberg Carlos Augusto Gomes Harumi Gomi Manuel Guzmán-Blanco Mainul Haque Sonja Hansen Andreas Hecker Wolfgang R Heizmann Torsten Herzog Adrien Montcho Hodonou Suk-Kyung Hong Reinhold Kafka-Ritsch Lewis J Kaplan Garima Kapoor Aleksandar Karamarkovic Martin G Kees Jakub Kenig Ronald Kiguba Peter K Kim Yoram Kluger Vladimir Khokha Kaoru Koike Kenneth Y Y Kok Victory Kong Matthew C Knox Kenji Inaba Arda Isik Katia Iskandar Rao R Ivatury Maurizio Labbate Francesco M Labricciosa Pierre-François Laterre Rifat Latifi Jae Gil Lee Young Ran Lee Marc Leone Ari Leppaniemi Yousheng Li Stephen Y Liang Tonny Loho Marc Maegele Sydney Malama Hany E Marei Ignacio Martin-Loeches Sanjay Marwah Amos Massele Michael McFarlane Renato Bessa Melo Ionut Negoi David P Nicolau Carl Erik Nord Richard Ofori-Asenso AbdelKarim H Omari Carlos A Ordonez Mouaqit Ouadii Gerson Alves Pereira Júnior Diego Piazza Guntars Pupelis Timothy Miles Rawson Miran Rems Sandro Rizoli Claudio Rocha Boris Sakakushev Miguel Sanchez-Garcia Norio Sato Helmut A Segovia Lohse Gabriele Sganga Boonying Siribumrungwong Vishal G Shelat Kjetil Soreide Rodolfo Soto Peep Talving Jonathan V Tilsed Jean-Francois Timsit Gabriel Trueba Ngo Tat Trung Jan Ulrych Harry van Goor Andras Vereczkei Ravinder S Vohra Imtiaz Wani Waldemar Uhl Yonghong Xiao Kuo-Ching Yuan Sanoop K Zachariah Jean-Ralph Zahar Tanya L Zakrison Antonio Corcione Rita M Melotti Claudio Viscoli Perluigi Viale

World J Emerg Surg 2016 15;11:33. Epub 2016 Jul 15.

Infectious Diseases Unit, Department of Medical and Surgical Sciences, Sant' Orsola Hospital, University of Bologna, Bologna, Italy.

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http://dx.doi.org/10.1186/s13017-016-0089-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4946132PMC
May 2018

The Maturing Antibiotic Mantra: "Shorter Is Still Better".

Authors:
Brad Spellberg

J Hosp Med 2018 05 25;13(5):361.362. Epub 2018 Jan 25.

Los Angeles County + University of Southern California (LAC+USC) Medical Center, Los Angeles, California, USA.

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http://dx.doi.org/10.12788/jhm.2904DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6483376PMC
May 2018

No More 'Code Black': Intervention to Improve Inpatient Flow at a Large Public Hospital.

Am J Med 2018 04 22;131(4):371-376. Epub 2017 Nov 22.

Los Angeles County + University of Southern California (LAC+USC) Medical Center, Los Angeles, Calif; Department of Medicine, Keck School of Medicine at USC, Los Angeles, Calif.

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http://dx.doi.org/10.1016/j.amjmed.2017.10.050DOI Listing
April 2018

Busting the Myth of "Static vs Cidal": A Systemic Literature Review.

Clin Infect Dis 2018 Apr;66(9):1470-1474

Los Angeles County + University of Southern California Medical Center.

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http://dx.doi.org/10.1093/cid/cix1127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5905615PMC
April 2018

Mucormycosis pathogenesis: Beyond Rhizopus.

Authors:
Brad Spellberg

Virulence 2017 11 25;8(8):1481-1482. Epub 2017 Aug 25.

a Division of Infectious Diseases , Los Angeles County + University of Southern California (LAC+USC) Medical Center , Los Angeles , CA , USA.

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http://dx.doi.org/10.1080/21505594.2017.1364335DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5810489PMC
November 2017

Preserving the Health of the Public and Our Specialty.

Authors:
Brad Spellberg

Clin Infect Dis 2017 10;65(9):1597

Los Angeles County-University of Southern California (LAC + USC) Medical Center.

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http://dx.doi.org/10.1093/cid/cix572DOI Listing
October 2017

Diabetes Exacerbates Infection via Hyperinflammation by Signaling through TLR4 and RAGE.

MBio 2017 08 22;8(4). Epub 2017 Aug 22.

Department of Medicine and Department of Molecular Microbiology and Immunology, Keck School of Medicine at the University of Southern California (USC), Los Angeles, California, USA.

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http://dx.doi.org/10.1128/mBio.00818-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5565964PMC
August 2017

Leveraging antimicrobial stewardship into improving rates of carbapenem-resistant Enterobacteriaceae.

Virulence 2017 05 17;8(4):383-390. Epub 2016 May 17.

a Division of Infectious Diseases , USC Keck School of Medicine , Los Angeles , CA , USA.

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http://dx.doi.org/10.1080/21505594.2016.1188234DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5477703PMC
May 2017

Sacubitril-Valsartan in Heart Failure.

Authors:
Brad Spellberg

Ann Intern Med 2017 05;166(9):680

From LAC+USC Medical Center and Keck School of Medicine at USC, Los Angeles, California.

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http://dx.doi.org/10.7326/L17-0047DOI Listing
May 2017

Selectable Markers for Use in Genetic Manipulation of Extensively Drug-Resistant (XDR) HUMC1.

mSphere 2017 Mar-Apr;2(2). Epub 2017 Apr 26.

Department of Medicine, University of Southern California Keck School of Medicine, Los Angeles, California, USA.

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http://dx.doi.org/10.1128/mSphere.00140-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5422034PMC
April 2017

Clinical and Pathophysiological Overview of Acinetobacter Infections: a Century of Challenges.

Clin Microbiol Rev 2017 01;30(1):409-447

Division of Infectious Diseases, Keck School of Medicine of the University of Southern California (USC), Los Angeles, California, USA.

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http://dx.doi.org/10.1128/CMR.00058-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5217799PMC
January 2017

Editorial Commentary: Ceftazidime-Avibactam and Carbapenem-Resistant Enterobacteriaceae: "We're Gonna Need a Bigger Boat".

Clin Infect Dis 2016 12 13;63(12):1619-1621. Epub 2016 Sep 13.

Departments of Medicine, Pharmacology, and Molecular Biology and Microbiology, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Case Western Reserve University, Ohio.

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http://dx.doi.org/10.1093/cid/ciw639DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5146721PMC
December 2016

How to Pitch an Antibiotic Stewardship Program to the Hospital C-Suite.

Open Forum Infect Dis 2016 Oct 15;3(4):ofw210. Epub 2016 Oct 15.

Division of Infectious Diseases, Providence Portland Medical Center , Oregon.

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http://dx.doi.org/10.1093/ofid/ofw210DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5104972PMC
October 2016

The New Antibiotic Mantra-"Shorter Is Better".

Authors:
Brad Spellberg

JAMA Intern Med 2016 09;176(9):1254-5

Los Angeles County+University of Southern California Medical Center, Los Angeles2Department of Medicine, Keck School of Medicine at University of Southern California, Los Angeles.

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http://dx.doi.org/10.1001/jamainternmed.2016.3646DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5233409PMC
September 2016

Debunking the July Effect Myth.

J Patient Saf 2016 Sep 8. Epub 2016 Sep 8.

Los Angeles County University of Southern California (LAC+USC) Medical Center, Los Angeles, CA.

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http://dx.doi.org/10.1097/PTS.0000000000000308DOI Listing
September 2016

The VITAL study: case control studies are hypothesis-generating.

Lancet Infect Dis 2016 08;16(8):886

David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, CA, USA.

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http://dx.doi.org/10.1016/S1473-3099(16)30154-2DOI Listing
August 2016

Trimethoprim-Sulfamethoxazole for Uncomplicated Skin Abscess.

Authors:
Brad Spellberg

N Engl J Med 2016 07;375(3):284

LAC+USC Medical Center, Los Angeles, CA

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http://dx.doi.org/10.1056/NEJMc1605392DOI Listing
July 2016

Important Complexities of the Antivirulence Target Paradigm: A Novel Ostensibly Resistance-Avoiding Approach for Treating Infections.

J Infect Dis 2016 Mar 12;213(6):901-3. Epub 2015 Nov 12.

Minneapolis Veterans Affairs Medical Center Department of Medicine, University of Minnesota, Minneapolis.

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http://dx.doi.org/10.1093/infdis/jiv533DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4760422PMC
March 2016

New Societal Approaches to Empowering Antibiotic Stewardship.

JAMA 2016 Mar 22-29;315(12):1229-30

Division of Infectious Diseases, University of California at San Francisco.

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http://dx.doi.org/10.1001/jama.2016.1346DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5611826PMC
March 2016

Noninferiority Doesn't Mean Not Inferior.

Clin Infect Dis 2016 Feb 20;62(4):525-6. Epub 2015 Oct 20.

Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California.

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http://dx.doi.org/10.1093/cid/civ895DOI Listing
February 2016

Ly6G-mediated depletion of neutrophils is dependent on macrophages.

Results Immunol 2016 21;6:5-7. Epub 2015 Dec 21.

Division of Infectious Diseases, Keck School of Medicine at USC, Los Angeles, CA, USA.

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http://dx.doi.org/10.1016/j.rinim.2015.12.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4711394PMC
February 2016

Boronic Acid Transition State Inhibitors Active against KPC and Other Class A β-Lactamases: Structure-Activity Relationships as a Guide to Inhibitor Design.

Antimicrob Agents Chemother 2016 Jan 4;60(3):1751-9. Epub 2016 Jan 4.

Research Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA Departments of Medicine, Case Western Reserve University, Cleveland, Ohio, USA Department of Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, Ohio, USA Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio, USA Department of Pharmacology, Case Western Reserve University, Cleveland, Ohio, USA

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http://dx.doi.org/10.1128/AAC.02641-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4776006PMC
January 2016

The Rise of Fluoroquinolone-Resistant Escherichia coli in the Community: Scarier Than We Thought.

J Infect Dis 2015 Dec 12;212(12):1853-5. Epub 2015 May 12.

Division of Infectious Diseases, University of Pittsburgh Medical Center, Pennsylvania.

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http://dx.doi.org/10.1093/infdis/jiv279DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4655852PMC
December 2015

Cryopreservation of virulent Acinetobacter baumannii to reduce variability of in vivo studies.

BMC Microbiol 2015 Nov 2;15:252. Epub 2015 Nov 2.

Department of Medicine, Keck School of Medicine at USC, Los Angeles, CA, USA.

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http://dx.doi.org/10.1186/s12866-015-0580-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4630970PMC
November 2015

Transferrin-mediated iron sequestration as a novel therapy for bacterial and fungal infections.

Curr Opin Microbiol 2015 Oct 9;27:57-61. Epub 2015 Aug 9.

Department of Medicine, Keck School of Medicine at USC, Los Angeles, United States.

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http://dx.doi.org/10.1016/j.mib.2015.07.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4659759PMC
October 2015

Combination Therapy for Extreme Drug-Resistant Acinetobacter baumannii: Ready for Prime Time?

Crit Care Med 2015 Jun;43(6):1332-4

Division of Infectious Diseases, Keck School of Medicine at USC and the Los Angeles County-USC Medical Center, Los Angeles, CA Department of Medicine, Department of Pharmacology, Department of Molecular Biology and Microbiology, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Case Western Reserve University, Cleveland, OH.

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http://dx.doi.org/10.1097/CCM.0000000000001029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4620434PMC
June 2015

Readmissions at a public safety net hospital.

PLoS One 2014 11;9(3):e91244. Epub 2014 Mar 11.

Division of General Internal Medicine, Los Angeles Biomedical Research Institute at Harbor-University of California at Los Angeles (UCLA) Medical Center, Torrance, California, United States of America; David Geffen School of Medicine at University of California at Los Angeles (UCLA), Los Angeles, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0091244PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3949745PMC
May 2015

Host fate is rapidly determined by innate effector-microbial interactions during Acinetobacter baumannii bacteremia.

J Infect Dis 2015 Apr 5;211(8):1296-305. Epub 2014 Nov 5.

Department of Medicine, Division of Infectious Diseases, Keck School of Medicine, University of Southern California, Los Angeles.

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http://dx.doi.org/10.1093/infdis/jiu593DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4447835PMC
April 2015

A simple intervention to improve hospital flow from emergency department to inpatient units.

JAMA Intern Med 2015 Feb;175(2):289-90

Los Angeles County + University of Southern California Medical Center, Los Angeles8Department of Medicine, Keck University School of Medicine, University of Southern California, Los Angeles.

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http://dx.doi.org/10.1001/jamainternmed.2014.6689DOI Listing
February 2015

Novel approaches are needed to develop tomorrow's antibacterial therapies.

Am J Respir Crit Care Med 2015 Jan;191(2):135-40

1 Los Angeles County-University of Southern California Medical Center, Los Angeles, California.

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http://dx.doi.org/10.1164/rccm.201410-1894OEDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4347440PMC
January 2015

Volume of fluids administered during resuscitation for severe sepsis and septic shock and the development of the acute respiratory distress syndrome.

J Crit Care 2014 Dec 13;29(6):1011-5. Epub 2014 Jun 13.

General Internal Medicine, Los Angeles County Department of Health Services and Los Angeles Biomedical Research Institute at Harbor-University of California Los Angeles Medical Center, Torrance, CA, USA.

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http://dx.doi.org/10.1016/j.jcrc.2014.06.005DOI Listing
December 2014

Staphylococcus aureus bacteremia at 5 US academic medical centers, 2008-2011: significant geographic variation in community-onset infections.

Clin Infect Dis 2014 Sep 30;59(6):798-807. Epub 2014 May 30.

Department of David Geffen School of Medicine, University of California, Los Angeles (UCLA) Division of General Internal Medicine, Harbor-UCLA Medical Center and the Los Angeles Biomedical Research Institute, Torrance, California.

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https://academic.oup.com/cid/article-lookup/doi/10.1093/cid/
Publisher Site
http://dx.doi.org/10.1093/cid/ciu410DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4200044PMC
September 2014

The future of antibiotics and resistance: a tribute to a career of leadership by John Bartlett.

Clin Infect Dis 2014 Sep;59 Suppl 2:S71-5

Department of Medical Education, Providence Portland Medical Center and Oregon Health Sciences University, Portland.

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http://dx.doi.org/10.1093/cid/ciu392DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4176319PMC
September 2014

Does real-time feedback to residents with or without attendings improve medical documentation?

Hosp Pract (1995) 2014 Aug;42(3):123-30

Department of Medicine, Harbor-University of California at Los Angeles (UCLA) Medical Center, Los Angeles, CA.

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http://dx.doi.org/10.3810/hp.2014.08.1126DOI Listing
August 2014

Transferrin iron starvation therapy for lethal bacterial and fungal infections.

J Infect Dis 2014 Jul 19;210(2):254-64. Epub 2014 Jan 19.

The Los Angeles Biomedical Research Institute, Torrance, California The Division of General Internal Medicine, Harbor-University of California at Los Angeles (UCLA) Medical Center, Torrance The David Geffen School of Medicine at UCLA, Los Angeles.

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http://dx.doi.org/10.1093/infdis/jiu049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4092247PMC
July 2014

Different tumor necrosis factor α antagonists have different effects on host susceptibility to disseminated and oropharyngeal candidiasis in mice.

Virulence 2014 Jul 9;5(5):625-9. Epub 2014 Jul 9.

Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center; Torrance, CA USA; David Geffen School of Medicine at University of California at Los Angeles; Los Angeles, CA USA.

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http://dx.doi.org/10.4161/viru.29699DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4105312PMC
July 2014

The future of antibiotics.

Authors:
Brad Spellberg

Crit Care 2014 Jun 27;18(3):228. Epub 2014 Jun 27.

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http://dx.doi.org/10.1186/cc13948DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4075146PMC
June 2014

The deadly impact of extreme drug resistance in Acinetobacter baumannii.

Crit Care Med 2014 May;42(5):1289-91

Division of General Internal Medicine, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA; and, Division of General Internal Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA Department of Medicine, Department of Pharmacology; and, Department of Molecular Biology and Microbiology, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Case Western Reserve University, Cleveland, OH.

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http://dx.doi.org/10.1097/CCM.0000000000000181DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4184139PMC
May 2014

Community-acquired pneumonia.

Authors:
Brad Spellberg

N Engl J Med 2014 05;370(19):1861-2

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http://dx.doi.org/10.1056/NEJMc1402692DOI Listing
May 2014

Antibiotic judo: working gently with prescriber psychology to overcome inappropriate use.

Authors:
Brad Spellberg

JAMA Intern Med 2014 Mar;174(3):432-3

Division of General Internal Medicine, Harbor-UCLA Medical Center, Los Angeles, California2Los Angeles Biomedical Research Institute, Torrance, California3David Geffen School of Medicine at UCLA, Los Angeles, California.

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http://dx.doi.org/10.1001/jamainternmed.2013.14019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4064591PMC
March 2014

Impact of hospital variables on case mix index as a marker of disease severity.

Popul Health Manag 2014 Feb 21;17(1):28-34. Epub 2013 Aug 21.

1 Division of General Internal Medicine, Harbor-University of California Los Angeles (UCLA) Medical Center , Los Angeles, California.

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http://dx.doi.org/10.1089/pop.2013.0002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3931432PMC
February 2014

Routine CSF analysis in coccidioidomycosis is not required.

PLoS One 2013 22;8(5):e64249. Epub 2013 May 22.

Coccidioidomycosis Serology Laboratory, Department of Medical Microbiology and Immunology, University of California Davis, Davis, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0064249PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661666PMC
January 2014

The value of single-pathogen antibacterial agents.

Nat Rev Drug Discov 2013 12 15;12(12):963. Epub 2013 Nov 15.

1] Division of General Internal Medicine, Los Angeles Biomedical Research Institute, Harbor-UCLA Medical Center, Los Angeles, California 90502, USA. [2] David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California 90095, USA.

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http://dx.doi.org/10.1038/nrd3957-c1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4012226PMC
December 2013

The FDA reboot of antibiotic development.

Antimicrob Agents Chemother 2013 Oct 29;57(10):4605-7. Epub 2013 Jul 29.

Anti-infectives Consulting, LLC, Stonington, Connecticut, USA.

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http://dx.doi.org/10.1128/AAC.01277-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3811409PMC
October 2013

Capturing the diagnosis: an internal medicine education program to improve documentation.

Am J Med 2013 Aug 18;126(8):739-743.e1. Epub 2013 Jun 18.

Division of General Internal Medicine, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.

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http://dx.doi.org/10.1016/j.amjmed.2012.11.035DOI Listing
August 2013

Seven ways to preserve the miracle of antibiotics.

Clin Infect Dis 2013 May 12;56(10):1445-50. Epub 2013 Feb 12.

Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.1093/cid/cit070DOI Listing
May 2013

End points in trials of treatments for skin infections.

Authors:
Brad Spellberg

JAMA 2013 May;309(20):2091-2

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http://dx.doi.org/10.1001/jama.2013.4541DOI Listing
May 2013

The K1 capsular polysaccharide from Acinetobacter baumannii is a potential therapeutic target via passive immunization.

Infect Immun 2013 Mar 7;81(3):915-22. Epub 2013 Jan 7.

Veterans Administration Western New York Healthcare System, University at Buffalo-State University of New York, Buffalo, New York, USA.

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http://dx.doi.org/10.1128/IAI.01184-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3584894PMC
March 2013

On the exoneration of Dr. William H. Stewart: debunking an urban legend.

Infect Dis Poverty 2013 Feb 18;2(1). Epub 2013 Feb 18.

Los Angeles Biomedical Research Institute at Harbor-University of California at Los Angeles (UCLA) Medical Center, Torrance, CA, USA.

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http://dx.doi.org/10.1186/2049-9957-2-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3707092PMC
February 2013

Acinetobacter baumannii rOmpA vaccine dose alters immune polarization and immunodominant epitopes.

Vaccine 2013 Jan 12;31(2):313-8. Epub 2012 Nov 12.

Division of General Internal Medicine, Los Angeles Biomedical Research Institute at Harbor-University of California at Los Angeles Medical Center, Torrance, CA 90502, United States.

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http://dx.doi.org/10.1016/j.vaccine.2012.11.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3557524PMC
January 2013

The future of antibiotics and resistance.

N Engl J Med 2013 Jan;368(4):299-302

Division of General Internal Medicine, Los Angeles Biomedical Research Institute at Harbor-University of California Los Angeles (UCLA) Medical Center and the David Geffen School of Medicine at UCLA, Los Angeles, USA.

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http://www.nejm.org/doi/10.1056/NEJMp1215093
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http://dx.doi.org/10.1056/NEJMp1215093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3617123PMC
January 2013

Overcoming the challenges to developing new antibiotics.

Curr Opin Pharmacol 2012 Oct 24;12(5):522-6. Epub 2012 Jul 24.

Anti-infectives Consulting, LLC, Stonington, CT, USA.

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http://dx.doi.org/10.1016/j.coph.2012.06.010DOI Listing
October 2012

Risk factors for mortality in patients with mucormycosis.

Med Mycol 2012 Aug 21;50(6):611-8. Epub 2012 Mar 21.

Division of General Internal Medicine, Los Angeles Biomedical Research Institute, Harbor-University of California Los Angeles (UCLA) Medical Center, Los Angeles, CA, USA.

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http://dx.doi.org/10.3109/13693786.2012.669502DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3951871PMC
August 2012

A controlled investigation of optimal internal medicine ward team structure at a teaching hospital.

PLoS One 2012 19;7(4):e35576. Epub 2012 Apr 19.

Division of General Internal Medicine, Los Angeles Biomedical Research Institute at Harbor-University of California Los Angeles Medical Center, Torrance, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0035576PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3330818PMC
August 2012

Diabetic murine models for Acinetobacter baumannii infection.

J Antimicrob Chemother 2012 Jun 2;67(6):1439-45. Epub 2012 Mar 2.

Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA 90502, USA.

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http://dx.doi.org/10.1093/jac/dks050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3584961PMC
June 2012

Active and passive immunization protects against lethal, extreme drug resistant-Acinetobacter baumannii infection.

PLoS One 2012 10;7(1):e29446. Epub 2012 Jan 10.

Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor-University of California Los Angeles (UCLA) Medical Center, Torrance, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0029446PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3254619PMC
May 2012

Macrophage killing of bacterial and fungal pathogens is not inhibited by intense intracellular accumulation of the lipoglycopeptide antibiotic oritavancin.

Clin Infect Dis 2012 Apr;54 Suppl 3:S229-32

Division of General Internal Medicine, Los Angeles Biomedical Research Institute at Harbor-University of California at Los Angeles (UCLA) Medical Center, Torrance, CA 90502, USA.

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http://dx.doi.org/10.1093/cid/cir921DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3307583PMC
April 2012

The Deferasirox-AmBisome Therapy for Mucormycosis (DEFEAT Mucor) study: a randomized, double-blinded, placebo-controlled trial.

J Antimicrob Chemother 2012 Mar 20;67(3):715-22. Epub 2011 Sep 20.

Division of General Internal Medicine, Los Angeles Biomedical Research Institute, Harbor-University of California Los Angeles (UCLA) Medical Center, Torrance, CA, USA.

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http://dx.doi.org/10.1093/jac/dkr375DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3383100PMC
March 2012

Development of a vaccine against Staphylococcus aureus.

Semin Immunopathol 2012 Mar 14;34(2):335-48. Epub 2011 Nov 14.

The Division of General Internal Medicine, Los Angeles Biomedical Research Institute, Harbor-University of California at Los Angeles Medical Center, Los Angeles, CA, USA.

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http://dx.doi.org/10.1007/s00281-011-0293-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4184131PMC
March 2012

Systemic antibiotic therapy for chronic osteomyelitis in adults.

Clin Infect Dis 2012 Feb 12;54(3):393-407. Epub 2011 Dec 12.

Division of General Internal Medicine, Los Angeles Biomedical Research Institute at Harbor-UCLA, Torrance, CA 90502, USA.

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http://dx.doi.org/10.1093/cid/cir842DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3491855PMC
February 2012

Progress toward a Staphylococcus aureus vaccine.

Clin Infect Dis 2012 Feb 20;54(4):560-7. Epub 2011 Dec 20.

Department of Pediatrics, Section of Infectious Diseases, The University of Chicago Medical Center, Chicago, IL, USA.

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http://dx.doi.org/10.1093/cid/cir828DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3404717PMC
February 2012

Pathogenesis of mucormycosis.

Clin Infect Dis 2012 Feb;54 Suppl 1:S16-22

Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, University of California-Los Angeles, 1124 W Carson St., Torrance, CA 90502, USA.

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http://academic.oup.com/cid/article/54/suppl_1/S16/284344/Pa
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http://dx.doi.org/10.1093/cid/cir865DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3286196PMC
February 2012

How does antifungal pharmacology differ for mucormycosis versus aspergillosis?

Clin Infect Dis 2012 Feb;54 Suppl 1:S67-72

Department of College of Pharmacy, The University of Houston, TX 77030, USA.

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http://dx.doi.org/10.1093/cid/cir884DOI Listing
February 2012

Combination therapy for mucormycosis: why, what, and how?

Clin Infect Dis 2012 Feb;54 Suppl 1:S73-8

Division of General Internal Medicine, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, University of California at Los Angeles, 1124 West Carson St., Torrance, CA 90502, USA.

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http://dx.doi.org/10.1093/cid/cir885DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4542574PMC
February 2012

Future directions in mucormycosis research.

Clin Infect Dis 2012 Feb;54 Suppl 1:S79-85

Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA.

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http://academic.oup.com/cid/article/54/suppl_1/S79/286067/Fu
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http://dx.doi.org/10.1093/cid/cir886DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3258101PMC
February 2012

Gastrointestinal mucormycosis: an evolving disease.

Authors:
Brad Spellberg

Gastroenterol Hepatol (N Y) 2012 Feb;8(2):140-2

Division of General Internal Medicine, Los Angeles Biomedical Institute at Harbor-UCLA Medical Center, Torrance, California; David Geffen School of Medicine at UCLA, Los Angeles, California.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3317515PMC
February 2012

Luminescent-activated transfected killer cells to monitor leukocyte trafficking during systemic bacterial and fungal infection.

J Infect Dis 2012 Jan 28;205(2):337-47. Epub 2011 Nov 28.

Department of Medicine, Division of General Internal Medicine, Los Angeles Biomedical Research Institute, Harbor-University of California at Los Angeles Medical Center, Torrance, CA, USA.

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http://dx.doi.org/10.1093/infdis/jir725DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3244365PMC
January 2012

Acute bacterial skin and skin structure infection trials: the bad is the enemy of the good.

Authors:
Brad Spellberg

Clin Infect Dis 2011 Dec 25;53(12):1308-9; author reply 1309-10. Epub 2011 Oct 25.

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http://dx.doi.org/10.1093/cid/cir741DOI Listing
December 2011