Publications by authors named "Bowen Li"

486 Publications

Fabrication of hydrangea-shaped BiWO/ZIF-8 visible-light responsive photocatalysts for degradation of methylene blue.

Chemosphere 2022 Aug 9:135949. Epub 2022 Aug 9.

School of Chemical and Environmental Engineering, China University of Mining and Technology, Beijing, 100083, China.

In this paper, the hydrangea-shaped BiWO/ZIF-8 (BWOZ) visible light photocatalysts have been prepared via a facile synthetic strategy for the first time. The constructed BWOZ composites were systematically studied by a series of characterization techniques. The SEM results manifested the octahedral ZIF-8 coated the flower-like BiWO uniformly and the composition of BWOZ composites had been confirmed by XPS measurement. And the photocatalytic activity was evaluated by eliminating methylene blue with the help of visible light. The results showed that 7%-BWOZ (7.0 wt% BiWO) exhibited better photodegradation capability than pure BiWO and ZIF-8. Compared with BiWO, the photocatalytic degradation of methylene blue by 7%-BWOZ could reach 85.7%. In addition, the pseudo-first-order kinetic constant of 7%-BWOZ was 23.00 and 1.61 times that of pristine BiWO and ZIF-8, respectively. The improved photocatalytic ability of BWOZ systems may be due to the construction of heterojunctions between BiWO and ZIF-8, which resulted in the rapid separation of photogenerated carriers. Additionally, the specific surface area of the formed BWOZ system was also improved in comparison with the flower-shaped BiWO, and thus more active sites could be provided to contact with methylene blue molecules, thereby achieving better removal capacity. Moreover, trapping experiments and electron spin resonance results further illustrated that the coexistence of multiple free radicals realized efficient degradation of methylene blue. More importantly, the photocatalytic property of the 7%-BWOZ composite remained even after three cycles. Furthermore, a feasible photodegradation mechanism was also explored in depth.
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http://dx.doi.org/10.1016/j.chemosphere.2022.135949DOI Listing
August 2022

Microbiota-assisted therapy for systemic inflammatory arthritis: advances and mechanistic insights.

Cell Mol Life Sci 2022 Aug 6;79(9):470. Epub 2022 Aug 6.

State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, China.

Research on the influence of gut microbiota on systemic inflammatory arthritis has exploded in the past decade. Gut microbiota changes may be a crucial regulatory component in systemic inflammatory arthritis. As a result of advancements in the field, microbiota-assisted therapy has evolved, but this discipline is still in its infancy. Consequently, we review the limitations of current systemic inflammatory arthritis treatment, analyze the connection between the microbiota and arthritis, and summarize the research progress of microbiota regulating systemic inflammatory arthritis and the further development aspects of microbiota-assisted therapy. Finally, the partial mechanisms of microbiota-assisted therapy of systemic inflammatory arthritis are being discussed. In general, this review summarizes the current progress, challenges, and prospects of microbiota-assisted therapy for systemic inflammatory arthritis and points out the direction for the development of microbiota-assisted therapy in the future.
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http://dx.doi.org/10.1007/s00018-022-04498-6DOI Listing
August 2022

FedIPR: Ownership Verification for Federated Deep Neural Network Models.

IEEE Trans Pattern Anal Mach Intell 2022 Aug 2;PP. Epub 2022 Aug 2.

Federated learning models are collaboratively developed upon valuable training data owned by multiple parties. During the development and deployment of federated models, they are exposed to risks including illegal copying, re-distribution, misuse and/or free-riding. To address these risks, the ownership verification of federated learning models is a prerequisite that protects federated learning model intellectual property rights (IPR) i.e., FedIPR. We propose a novel federated deep neural network (FedDNN) ownership verification scheme that allows private watermarks to be embedded and verified to claim legitimate IPR of FedDNN models. In the proposed scheme, each client independently verifies the existence of the model watermarks and claims respective ownership of the federated model without disclosing neither private training data nor private watermark information. The effectiveness of embedded watermarks is theoretically justified by the rigorous analysis of conditions under which watermarks can be privately embedded and detected by multiple clients. Moreover, extensive experimental results on computer vision and natural language processing tasks demonstrate that varying bit-length watermarks can be embedded and reliably detected without compromising original model performances. Our watermarking scheme is also resilient to various federated training settings and robust against removal attacks.
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http://dx.doi.org/10.1109/TPAMI.2022.3195956DOI Listing
August 2022

PDL1Binder: Identifying programmed cell death ligand 1 binding peptides by incorporating next-generation phage display data and different peptide descriptors.

Front Microbiol 2022 15;13:928774. Epub 2022 Jul 15.

School of Life Sciences and Technology, University of Electronic Science and Technology of China, Chengdu, China.

Monoclonal antibody drugs targeting the PD-1/PD-L1 pathway have showed efficacy in the treatment of cancer patients, however, they have many intrinsic limitations and inevitable drawbacks. Peptide inhibitors as alternatives might compensate for the drawbacks of current PD-1/PD-L1 interaction blockers. Identifying PD-L1 binding peptides by random peptide library screening is a time-consuming and labor-intensive process. Machine learning-based computational models enable rapid discovery of peptide candidates targeting the PD-1/PD-L1 pathway. In this study, we first employed next-generation phage display (NGPD) biopanning to isolate PD-L1 binding peptides. Different peptide descriptors and feature selection methods as well as diverse machine learning methods were then incorporated to implement predictive models of PD-L1 binding. Finally, we proposed PDL1Binder, an ensemble computational model for efficiently obtaining PD-L1 binding peptides. Our results suggest that predictive models of PD-L1 binding can be learned from deep sequencing data and provide a new path to discover PD-L1 binding peptides. A web server was implemented for PDL1Binder, which is freely available at http://i.uestc.edu.cn/pdl1binder/cgi-bin/PDL1Binder.pl.
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http://dx.doi.org/10.3389/fmicb.2022.928774DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9335124PMC
July 2022

Iron deficiency promotes aortic media degeneration by activating endoplasmic reticulum stress-mediated IRE1 signaling pathway.

Pharmacol Res 2022 Jul 23;183:106366. Epub 2022 Jul 23.

Department of Cardiovascular Surgery, Renmin Hospital of Wuhan University, 238# Jiefang Road, Wuhan 430000, Hubei Province, China; Cardiovascular Surgery Laboratory, Renmin Hospital of Wuhan University, 9# Zhangzhidong Road, Wuhan 430000, Hubei Province, China; Central Laboratory, Renmin Hospital of Wuhan University, 9# Zhangzhidong Road, Wuhan 430000, Hubei Province, China.

Background: Aortic dissection (AD) is a macrovascular disease which is pathologically characterized by aortic media degeneration (AMD). Our team's previous research found that iron deficiency (ID) promoted the formation of AMD through presentative research. In this study, we aimed to investigate the underlying mechanism of ID promoting AMD formation.

Methods: The human aortic tissues were harvested from AD patients and organ donors. ApoE-/- mice were simultaneously given AngII infusion and low-iron feed to investigate the relationship between ID and AD. The IRE1-XBP1-CHOP signal axis of endoplasmic reticulum (ER) stress was selectively inhibited with 4μ8C. Iron contents were detected by Perls staining. The expression of iron metabolism and ER stress-relative proteins were analyzed by IF and western blotting. Apoptosis rates of aortic tissue and ASMCs were detected by TUNEL staining and flow cytometry, and ROS content was also measured by the flow cytometry.

Results: ID was accompanied by ER stress in patients with AD. Among the three signaling pathways of ER stress in ID-induced AMD, proteins of IRE1, PERK and ATF6 signaling pathways were up-regulated by 2.65 times, 1.14 times and 1.24 times, respectively. ID was positively related to ER stress, mitochondrial oxidative stress and aortic media apoptosis in vivo and in vitro assays, while 4μ8C reversed the severity of ER stress and AMD.

Conclusions: ID could activate ER stress by eliciting mitochondrial oxidative stress to activate the IRE1-XBP1-CHOP signaling pathway in the ER, which accelerated the apoptosis of ASMCs in aortic media, thus promoting the formation of AMD.
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http://dx.doi.org/10.1016/j.phrs.2022.106366DOI Listing
July 2022

Heck Reaction of N-Heteroaryl Halides for the Concise Synthesis of Chiral α-Heteroaryl-substituted Heterocycles.

Angew Chem Int Ed Engl 2022 Jul 25. Epub 2022 Jul 25.

Shanghai Institute of Organic Chemistry, State Key Laboratory of Bio-Organic and Natural Products Chemistry, 345 Ling Ling Road, 200032, Shanghai, CHINA.

The Heck reaction between N -heteroaryl halides and heterocyclic alkenes provides a convenient approach to biologically relevant α-heteroaryl functionalized heterocycles, yet reactions of this type have been challenging due to strong N -heteroaryl coordination to palladium metal, which causes catalyst poisoning. In this report, an efficient palladium-catalyzed Heck reaction between N -heteroaryl halides and heterocyclic olefins is established, leading to a variety of α-heteroaryl substituted heterocycles. The method features an unprecedented broad substrate scope and excellent functional group compatibility. The employment of a sterically bulky P, P=O ligand containing an anthryl moiety is crucial for this transformation due to the coordinative unsaturation facilitated by its steric bulkiness. The asymmetric variant of the Heck reaction is achieved with ( S )-DTBM-SEGPHOS via a cationic palladium pathway, which has enabled an efficient asymmetric synthesis of ( S )-nicotine and its analogues.
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http://dx.doi.org/10.1002/anie.202209087DOI Listing
July 2022

Optimization of Antibacterial Activity in Tibetan Swine α-Helix Peptide TP by Site-Directed Mutagenesis.

Front Microbiol 2022 4;13:864374. Epub 2022 Jul 4.

Institute of Animal Nutrition, Northeast Agricultural University, Harbin, China.

Antimicrobial peptides (AMPs) have attracted extensive attention because of their broad-spectrum antibacterial activity and low level of induced bacterial resistance. However, the development of some natural AMPs does not consider the perfect balance of structural characteristics, resulting in some empirical and controversial practices still existing. To further explore and complete the relationship between parameters and function of α-helix peptide, in this study, the natural antimicrobial peptide TP secreted from Bacillus strain of Tibetan pigs was selected as a template to investigate the effect of systematic mutations in the hydrogen bond formation site of the α-helical antimicrobial peptide on the activity and cell selectivity of the antimicrobial peptide. The target peptide TP(i+4) 1&2&5 with modification of two pairs of positively charged amino acids and a pair of hydrophobic amino acids showed excellent antibacterial ability and the best selectivity index (SI = 64) . At the same time, TP(i+4) 1&2&5 remained active in the presence of physiological salts and serum. The results of fluorescence, flow cytometry, and electron microscopy showed that the optimized sequences showed good antibacterial activity by membrane infiltration and membrane destruction. The potential of TP(i+4) 1&2&5 was tested in a mouse peritonitis model. Organ bacterial loads in the liver, kidney, spleen, and lungs of mice treated with TP(i+4) 1&2&5 were significantly lower compared to the infected group ( < 0.05). Overall, these findings contribute to the design and optimization of antimicrobial peptides with high activity and low toxicity and may accelerate the clinical application of antimicrobial peptides.
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http://dx.doi.org/10.3389/fmicb.2022.864374DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9289672PMC
July 2022

Enhanced Contrast of WO-Based Smart Windows by Continuous Li-Ion Insertion and Metal Electroplating.

ACS Appl Mater Interfaces 2022 Jul 8;14(28):32253-32260. Epub 2022 Jul 8.

National Synchrotron Radiation Laboratory, University of Science and Technology of China, Hefei 230026, China.

The electrochromic WO smart window based on an aqueous electrolyte shows an excellent liquid/solid interface and thus can achieve a fast electrochromic response, while the aqueous electrolyte has a limited electrochemical window, which probably induces the H reduction and degrades the practical application. Here, we propose a strategy to modify the traditional Li acidic aqueous electrolyte by adding some selective inert metal ions, which not only improve the electrochromic performance but also avoid the possible production of hydrogen bubbles due to the broadened electrochemical window. Furthermore, reversible electroplating of inert metal ions will occur, leading to an enhanced optical transmission change of up to 77.5% at 500 nm and 70.4% at 700 nm. This combination of Li-ion insertion and metal electroplating in the ESW device makes it superior to all of the previous reports. The device also demonstrates high stability and high electrochromic efficiency after 1000 cycles. The current study not only emphasizes the rational design for aqueous electrolytes but also demonstrates a practical way to realize an excellent electrochromic window for practical applications.
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http://dx.doi.org/10.1021/acsami.2c07546DOI Listing
July 2022

Neuropathy-associated Fars2 deficiency affects neuronal development and potentiates neuronal apoptosis by impairing mitochondrial function.

Cell Biosci 2022 Jul 6;12(1):103. Epub 2022 Jul 6.

Department of Anatomy, Histology and Embryology and K.K. Leung Brain Research Centre, School of Basic Medicine, Air Force Medical University, Xi'an, Shaanxi, People's Republic of China.

Background: Neurodegenerative diseases encompass an extensive and heterogeneous group of nervous system disorders which are characterized by progressive degeneration and death of neurons. Many lines of evidence suggest the participation of mitochondria dysfunction in these diseases. Mitochondrial phenylalanyl-tRNA synthetase, encoded by FARS2, catalyzes the transfer of phenylalanine to its cognate tRNA for protein synthesis. As a member of mt-aaRSs genes, FARS2 missense homozygous mutation c.424G > T (p.D142Y) found in a Chinese consanguineous family first built the relationship between pure hereditary spastic paraplegia (HSP) and FARS2 gene. More FARS2 variations were subsequently found to cause heterogeneous group of neurologic disorders presenting three main phenotypic manifestations: infantile-onset epileptic mitochondrial encephalopathy, later-onset spastic paraplegia and juvenile onset refractory epilepsy. Studies showed that aminoacylation activity is frequently disrupt in cases with FARS2 mutations, indicating a loss-of-function mechanism. However, the underlying pathogenesis of neuropathy-associated Fars2 deficiency is still largely unknown.

Results: Early gestation lethality of global Fars2 knockout mice was observed prior to neurogenesis. The conditional Fars2 knockout-mouse model delayed lethality to late-gestation, resulting in a thinner cortex and an enlarged ventricle which is consist with the MRI results revealing cortical atrophy and reduced cerebral white matter volume in FARS2-deficient patients. Delayed development of neurite outgrowth followed by neuronal apoptosis was confirmed in Fars2-knockdown mouse primary cultured neurons. Zebrafish, in which fars2 was knocked down, exhibited aberrant motor neuron function including reduced locomotor capacity which well restored the spastic paraplegia phenotype of FARS2-deficient patients. Altered mitochondrial protein synthesis and reduced levels of oxidative phosphorylation complexes were detected in Fars2-deficient samples. And thus, reduced ATP, total NAD levels and mitochondrial membrane potential, together with increased ROS production, revealed mitochondrial dysfunction both in vitro and in vivo. Dctn3 is a potential downstream molecule in responds to Fars2 deficient in neurons, which may provide some evidence for the development of pathogenesis study and therapeutic schedule.

Conclusions: The Fars2 deficiency genetic models developed in this study cover the typical clinical manifestations in FARS2 patients, and help clarify how neuropathy-associated Fars2 deficiency, by damaging the mitochondrial respiratory chain and impairing mitochondrial function, affects neuronal development and potentiates neuronal cell apoptosis.
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http://dx.doi.org/10.1186/s13578-022-00838-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9258231PMC
July 2022

Quantification of Tumor Abnormal Proteins in the Diagnosis and Postoperative Prognostic Evaluation of Gastric Cancer.

Clin Med Insights Oncol 2022 24;16:11795549221104440. Epub 2022 Jun 24.

Department of General Surgery, The First Affiliated Hospital, Nanjing Medical University, Nanjing, China.

Background: Abnormal glycosylation of proteins has been identified in almost all types of cancers and is closely related to the cancer progression, metastasis, and survival of cancer patients. This study was to explore the values of serum tumor abnormal protein (TAP), an abnormal glycochain protein, in the diagnosis and prognosis of gastric cancer (GC).

Methods: A total of 335 GC patients were included as the study group, and another 335 subjects served as the control group. Tumor abnormal protein expression was compared between the 2 groups. Correlation analysis was used to assess the correlations of TAP with clinicopathological factors. Gastric cancer patients were divided into training set and test set at a ratio of 2:1. Univariate and multivariate Cox regression analyses in training set were used to evaluate the prognostic significance of TAP in GC patients and explore the independent risk factors for overall survival (OS) and disease-free survival (DFS) to establish a prognostic model, followed by testing of the model. According to the median of TAP, 335 GC patients were divided into 2 groups to plot the survival curves of OS and DFS.

Results: Tumor abnormal protein expression in the study group was significantly higher than in the control group. Taking the best cut-off value of TAP (110.128 μm) as the diagnostic criteria for GC, the sensitivity and specificity of TAP were 83.58% and 97.61%, respectively, and the area under the receiver operating characteristics (ROC) curve was 0.935, which was not inferior to computed tomography (CT). Tumor abnormal protein expression was an independent risk factor for OS and DFS. The prognostic predictive value of TAP was better than that of pathological stage in GC patients. The model with TAP was effective in predicting prognosis.

Conclusion: Tumor abnormal protein is an effective indicator for early screening and prognostic evaluation of GC and can also assist the clinical diagnosis and treatment of GC.
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http://dx.doi.org/10.1177/11795549221104440DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9237931PMC
June 2022

Obesity, peptic ulcer disease and metabolic status in the Wuwei Cohort of northwest China: A cross-sectional study.

Asia Pac J Clin Nutr 2022 ;31(2):294-304

The First School of Clinical Medicine, Lanzhou University, Lanzhou, China. Email:

Background And Objectives: Peptic ulcer disease is a common digestive system disease. However, whether peptic ulcer disease and obesity are related is unclear. We assessed the associations of obesity and metabolic status with peptic ulcer disease.

Methods And Study Design: We conducted a cross-sectional study of 3561 individuals from the Wuwei cohort. We evaluated the associations of general and abdominal adiposity, as defined by different anthropometric indices, with peptic ulcer disease. Odds ratios and 95% confidence intervals were determined through binary logistic regression.

Results: The odds ratio for peptic ulcer disease was 2.37 (1.46-3.84) for women with obesity, compared with the normal group. The association remained significant in Models 2 and 3, with odds ratios of 2.23 (1.35-3.69) and 2.03 (1.19-3.49), respectively. In Model 1, women with obesity had an odds ratio for duodenal ulcer of 2.76 (1.41-5.42) compared with the control group; this result remained significant in Models 2 and 3, with odds ratios of 2.52 (1.24-5.13) and 2.44 (1.13-5.28), respectively. In Model 1, women with metabolically healthy and unhealthy obesity had odds ratios for peptic ulcer disease of 2.26 (1.19-4.28) and 2.15 (1.12-4.15), respectively, compared with the control group. After adjustments for major covariates and H. pylori status, these respective odds ratios became 2.27 (1.20-4.30) and 2.17 (1.12-4.20) in Model 2 and 2.2 (1.15-4.20) and 2.16 (1.11-4.19) in Model 3.

Conclusions: General adiposity defined by body mass index is associated with peptic ulcer disease in women.
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http://dx.doi.org/10.6133/apjcn.202206_31(2).0015DOI Listing
July 2022

Laparoscopic Subtotal Gastrectomy and Sigmoidectomy Combined With Natural Orifice Specimen Extraction Surgery (NOSES) for Synchronous Gastric Cancer and Sigmoid Colon Cancer: A Case Report.

Front Surg 2022 8;9:907288. Epub 2022 Jun 8.

Department of General Surgery, The First Affiliated Hospital of Weifang Medical College, Weifang People's Hospital, Weifang, China.

Background: Gastric cancer and colon cancer are rarely seen in clinic, but there are still related reports. For gastric cancer and simultaneous colon cancer, surgical resection is the main treatment. Traditional surgery requires an incision from xiphoid process to pubic symphysis. With the progress of minimally invasive technology, laparoscopic surgery is also used in the treatment of gastric cancer, but also in the abdominal incision to remove specimens and in vitro anastomosis of digestive tract. Taking specimens through the natural cavity as a new surgical method can not only reduce the abdominal incision, but also reduce the occurrence of wound-related complications. Here, we report a patient with gastric cancer and colon cancer who was treated in our hospital.

Case Summary: We report a series of patients with gastric cancer and colon cancer. upper abdominal pain was treated in our hospital for 6 months. electronic gastroscopy showed large irregular ulcers on the lesser curvature of the gastric antrum and biopsy showed poorly differentiated adenocarcinoma of the gastric antrum. The enhanced CT of abdomen and pelvis showed irregular thickening of gastric antrum wall, irregular thickening of sigmoid colon wall and no obvious enlarged lymph nodes around. Further electronic enteroscopy showed that the sigmoid colon showed cauliflower protuberance, the intestinal cavity was slightly narrow, the intestinal wall was stiff, and the biopsy pathology showed moderately differentiated adenocarcinoma of the sigmoid colon. No obvious abnormality was found in serological tumor indexes. We diagnosed gastric cancer with sigmoid colon cancer and the patient received Laparoscopic subtotal gastrectomy and sigmoidectomy combined with natural orifice specimen extraction surgery. At present, 12 months after operation, no clear tumor recurrence was found in the metastasis.

Conclusion: We should improve the understanding of gastric cancer and sigmoid cancer and combine examination with pathology to avoid misdiagnosis as metastatic cancer. Laparoscopic subtotal gastrectomy should be performed for tumors with no serosa invasion, body mass index <30 and tumor diameter <6.5 cm. Sigmoidectomy combined with natural nostril sampling is feasible.
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http://dx.doi.org/10.3389/fsurg.2022.907288DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9213650PMC
June 2022

Antioxidant Therapy in Cancer: Rationale and Progress.

Antioxidants (Basel) 2022 Jun 8;11(6). Epub 2022 Jun 8.

State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu 610041, China.

Cancer is characterized by increased oxidative stress, an imbalance between reactive oxygen species (ROS) and antioxidants. Enhanced ROS accumulation, as a result of metabolic disturbances and signaling aberrations, can promote carcinogenesis and malignant progression by inducing gene mutations and activating pro-oncogenic signaling, providing a possible rationale for targeting oxidative stress in cancer treatment. While numerous antioxidants have demonstrated therapeutic potential, their clinical efficacy in cancer remains unproven. Here, we review the rationale for, and recent advances in, pre-clinical and clinical research on antioxidant therapy in cancer, including targeting ROS with nonenzymatic antioxidants, such as NRF2 activators, vitamins, N-acetylcysteine and GSH esters, or targeting ROS with enzymatic antioxidants, such as NOX inhibitors and SOD mimics. In addition, we will offer insights into prospective therapeutic options for improving the effectiveness of antioxidant therapy, which may expand its applications in clinical cancer treatment.
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http://dx.doi.org/10.3390/antiox11061128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9220137PMC
June 2022

Perioperative Fluoroquinolone Treatment Deteriorates Prognosis Following Coronary Artery Bypass Grafting.

J Cardiovasc Dev Dis 2022 May 28;9(6). Epub 2022 May 28.

Department of Cardiovascular Surgery, Renmin Hospital of Wuhan University, 238 Jiefang Road, Wuhan 430060, China.

Background: Former studies have revealed that fluoroquinolone (FQ) can induce aortic expansion and rupture. While FQ is widely used in perioperative anti-infection therapy, its impact on graft patency and patient survival is unknown.

Methods: Coronary artery bypass grafting (CABG) data were extracted from the MIMIC-III database. Chi-square tests, Fisher's exact tests, -tests, or ANOVAs were used to compare baseline data between groups determined by FQ therapy status, depending on the data type. Propensity score matching was used to establish a balanced cohort. Cox regression was used to investigate the impact of FQ on CABG patient survival, whereas paired -tests were used to analyze secondary results.

Results: Of the 5030 patients who underwent CABG, 937 (18.6%) received oral or intravenous FQ therapy. Using propensity score matching, these 819 patients were successfully matched with 819 controls in a 1:1 ratio. Cox regression showed that FQ significantly decreased survival among CABG patients (HR: 1.62, 95% CI: 1.21-2.15, = 0.001). Furthermore, FQ usage was associated with longer hospitalization (<0.0001), ICU duration (<0.0001), ventilation period (<0.0001), and duration of vasopressor administration (<0.0001).

Conclusions: Perioperative FQ therapy was associated with worse prognosis and a more difficult recovery among patients with CABG.
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http://dx.doi.org/10.3390/jcdd9060173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9224777PMC
May 2022

Harnessing redox signaling to overcome therapeutic-resistant cancer dormancy.

Biochim Biophys Acta Rev Cancer 2022 Jul 15;1877(4):188749. Epub 2022 Jun 15.

State Key Laboratory of Biotherapy and Cancer Center, West China Hospital and West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu 610041, PR China. Electronic address:

Dormancy occurs when cells preserve viability but stop proliferating, which is considered an important cause of tumor relapse, which may occur many years after clinical remission. Since the life cycle of dormant cancer cells is affected by both intracellular and extracellular factors, gene mutation or epigenetic regulation of tumor cells may not fully explain the mechanisms involved. Recent studies have indicated that redox signaling regulates the formation, maintenance, and reactivation of dormant cancer cells by modulating intracellular signaling pathways and the extracellular environment, which provides a molecular explanation for the life cycle of dormant tumor cells. Indeed, redox signaling regulates the onset of dormancy by balancing the intrinsic pathways, the extrinsic environment, and the response to therapy. In addition, redox signaling sustains dormancy by managing stress homeostasis, maintaining stemness and immunogenic equilibrium. However, studies on dormancy reactivation are still limited, partly explained by redox-mediated activation of lipid metabolism and the transition from the tumor microenvironment to inflammation. Encouragingly, several drug combination strategies based on redox biology are currently under clinical evaluation. Continuing to gain an in-depth understanding of redox regulation and develop specific methods targeting redox modification holds the promise to accelerate the development of strategies to treat dormant tumors and benefit cancer patients.
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http://dx.doi.org/10.1016/j.bbcan.2022.188749DOI Listing
July 2022

A Novel Pseudogene Methylation Signature to Predict Temozolomide Outcome in Non-G-CIMP Glioblastomas.

J Oncol 2022 6;2022:6345160. Epub 2022 Jun 6.

School of Aerospace Medicine, Air Force Medical University, Xi'an, China.

Objective: Alterations in the methylation state of pseudogenes may serve as clinically useful biomarkers of glioblastomas (GBMs) that do not have glioma-CpG island methylator phenotype (G-CIMP).

Methods: Non-G-CIMP GBM datasets were included for evaluation, and a RISK-score signature was determined from the methylation state of pseudogene loci. Both bioinformatic and experimental analyses were performed for biological validation.

Results: By integrating clinical information with DNA methylation microarray data, we screened a panel of eight CpGs from discovery cohorts of non-G-CIMP GBMs. Each CpG could accurately and independently predict the prognosis of patients under a treatment regime that combined radiotherapy (RT) and temozolomide (TMZ). The 8-CpG signature appeared to show opposite prognostic correlations between patients treated with RT/TMZ and those treated with RT monotherapy. The analyses further indicated that this signature had predictive value for TMZ efficacy because different survival benefits between RT/TMZ and RT therapies were observed in each risk subgroup. The incorporation of other risk factors, such as age and O-6-methylguanine-DNA methyltransferase (MGMT) promoter methylation status, with our pseudogene methylation signature could provide precise risk classification. In vitro experimental data revealed that two locus-specific pseudogenes (ZNF767P and CLEC4GP1) may modulate TMZ resistance via distinct mechanisms in GBM cells.

Conclusion: The biologically and clinically relevant RISK-score signature, based on pseudogene methylation loci, may offer information for predicting TMZ responses of non-G-CIMP GBMs, that is independent from, but complementary to, MGMT-based approaches.
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http://dx.doi.org/10.1155/2022/6345160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9194959PMC
June 2022

Nickel-catalysed asymmetric hydrogenation of oximes.

Nat Chem 2022 Aug 13;14(8):920-927. Epub 2022 Jun 13.

Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, Frontiers Science Center for Transformative Molecules, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai, China.

Chiral hydroxylamines are vital substances in bioscience and versatile subunits in the preparation of a variety of functional molecules. However, asymmetric and non-asymmetric synthetic approaches to these compounds are far from satisfactory. Although atom-economic metal-catalysed asymmetric hydrogenations have been studied for over 50 years, the asymmetric hydrogenation of oximes to the corresponding chiral hydroxylamines remains challenging because of the labile N-O bond and inert C=N bond. Here we report an environmentally friendly, earth-abundant, transition-metal nickel-catalysed asymmetric hydrogenation of oximes, affording the corresponding chiral hydroxylamines with up to 99% yield, 99% e.e. and with a substrate/catalyst ratio of 1,000. Computational results indicate that the weak interactions between the catalyst and substrate play crucial roles not only in the transition states, but also during the approach of the substrate to the catalyst, by selectively reducing the reaction barriers and thus improving the reaction efficiency and securing the generation of chirality.
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http://dx.doi.org/10.1038/s41557-022-00971-8DOI Listing
August 2022

A database of anti-coronavirus peptides.

Sci Data 2022 06 13;9(1):294. Epub 2022 Jun 13.

Medical College, Guizhou University, Guiyang, 550025, China.

Since 2019, the novel coronavirus (SARS-COV-2) disease (COVID-19) has caused a worldwide epidemic. Anti-coronavirus peptides (ACovPs), a type of antimicrobial peptides (AMPs), have demonstrated excellent inhibitory effects on coronaviruses. However, state-of-the-art AMP databases contain only a small number of ACovPs. Additionally, the fields of these databases are not uniform, and the units or evaluation standards of the same field are inconsistent. Most of these databases have not included the target domains of ACovPs and description of in vitro and in vivo assays to measure the inhibitory effects of ACovPs. Here, we present a database focused on ACovPs (ACovPepDB), which contains comprehensive and precise ACovPs information of 518 entries with 214 unique ACovPs manually collected from public databases and published peer-reviewed articles. We believe that ACovPepDB is of great significance for facilitating the development of new peptides and improving treatment for coronavirus infection. The database will become a portal for ACovPs and guide and help researchers perform further studies. The ACovPepDB is available at http://i.uestc.edu.cn/ACovPepDB/ .
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http://dx.doi.org/10.1038/s41597-022-01394-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9192597PMC
June 2022

Indications and effects of biological agents in the treatment of noninfectious uveitis.

Immunotherapy 2022 Aug 13;14(12):985-994. Epub 2022 Jun 13.

Ophthalmologic Center of the Second Hospital, Jilin University, Ziqiang Street 218, Changchun, 130000, P.R. China.

Noninfectious uveitis is a common blinding eye disease, and an autoimmune response is involved in its pathogenesis. Biological agents have gradually been introduced into the treatment of noninfectious uveitis. The authors reviewed the clinical application and side effects of different biological agents on noninfectious uveitis. Biological agents that target TNF-α are widely used in the clinic. Other biological agents, such as IL-6- and IL-1-neutralizing antibodies, are used in patients who do not respond to TNF inhibitors. The efficacy of IL-17 neutralizing antibodies in noninfectious uveitis is controversial. Biological agents targeting T cells and signaling pathways provide new drug options for treatment of noninfectious uveitis. However, it cannot be ignored that these biological agents have side effects, such as increasing risk of infection.
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http://dx.doi.org/10.2217/imt-2021-0303DOI Listing
August 2022

Direct Laser Writing of Microscale Metal Oxide Gas Sensors from Liquid Precursors.

ACS Appl Mater Interfaces 2022 Jun 10;14(24):28163-28173. Epub 2022 Jun 10.

Department of Materials Science and Engineering, The Pennsylvania State University, University Park, Pennsylvania 16802 United States.

Fabrication and processing approaches that facilitate the ease of patterning and the integration of nanomaterials into sensor platforms are of significant utility and interest. In this work, we report the use of laser-induced thermal voxels (LITV) to fabricate microscale, planar gas sensors directly from solutions of metal salts. LITV offers a facile platform to directly integrate nanocrystalline metal oxide and mixed metal oxide materials onto heating platforms, with access to a wide variety of compositions and morphologies including many transition metals and noble metals. The unique patterning and synthesis flexibility of LITV enable the fabrication of chemically and spatially tailorable microscale sensing devices. We investigate the sensing performance of a representative set of n-type and p-type LITV-deposited metal oxides and their mixtures (CuO, NiO, CuO/ZnO, and FeO/Pt) in response to reducing and oxidizing gases (HS, NO, NH, ethanol, and acetone). These materials show a broad range of sensitivities and notably a strong response of NiO to ethanol and acetone (407 and 301% / at 250 °C, respectively), along with a 5- to 20-fold sensitivity enhancement for CuO/ZnO to all gases measured over pure CuO, highlighting the opportunities of LITV for the creation of mixed-material microscale sensors.
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http://dx.doi.org/10.1021/acsami.2c03561DOI Listing
June 2022

A small-molecule self-assembled nanodrug for combination therapy of photothermal-differentiation-chemotherapy of breast cancer stem cells.

Biomaterials 2022 07 24;286:121598. Epub 2022 May 24.

Institute of Biomedical Engineering, The First Affiliated Hospital (Shenzhen People's Hospital), Southern University of Science and Technology, Shenzhen, 518055, PR China. Electronic address:

The combination therapy with different treatment modalities has been widely applied in the clinical applications of cancer treatment. However, it stills a considerable challenge to achieve co-delivery of different drugs because of distinct drug encapsulation mechanisms, low drug loading, and high excipient-related toxicity. Cancer stem cells (CSCs) are closely related to tumor metastasis and recurrence due to high chemoresistance. Herein, we report a stimuli-responsive and tumor-targeted small-molecule self-assembled nanodrug for the combination therapy against CSCs and normal cancer cells. The hydrophobic differentiation-inducing agent (all-trans retinoic acid, ATRA) and hydrophilic anticancer drug (irinotecan, IRI) constitute this amphiphilic nanodrug, which could self-assemble into stable nanoparticles and encapsulate the photothermal agent IR825. Upon cellular uptake, this nanodrug display good release profiles in response to acid and esterase microenvironments by ester linkage. The released drugs not only increase chemotherapy sensitivity by the differentiation of CSCs into non-CSCs, but also exhibit superior cytotoxicity in cancer cells. In addition, IR825 within this nanodrug enables in vivo fluorescence/photoacoustic (PA) imaging allowing for tracking drug distribution. Moreover, the DSPE-PEG-RGD-functionalized nanodrug displayed high tumor accumulation and good biocompatibility, enabling efficient inhibition of tumor growth and tumor metastasis in tumor-bearing mice.
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http://dx.doi.org/10.1016/j.biomaterials.2022.121598DOI Listing
July 2022

Pulmonary cryptococcosis mimicking lung cancer: 3 case report.

Int J Surg Case Rep 2022 May 1;94:106973. Epub 2022 Apr 1.

Hebei General Hospital, Shijiazhuang, Hebei, China. Electronic address:

Introduction And Importance: Pulmonary cryptococcosis is an opportunistic pathogen. However, it is difficult to differentiate it from other diseases by imaging. Therefore, the clinical presentation and imaging features of patients with pulmonary cryptococcosis are analyzed and summarized to improve clinicians' early recognition of the disease.

Case Presentation: We present a case where preoperative imaging was difficult to differentiate between pulmonary cryptococcosis and non-small cell lung cancer. A pathological biopsy was taken by surgical treatment to clarify the diagnosis.

Clinical Discussion: Three cases of Cryptococcus pulmonary patients diagnosed by pathology in our department were analyzed. We believe that the diagnosis should be confirmed as soon as possible through surgery, relevant laboratory tests, and pathological examinations, and antifungal treatment should be carried out in time.

Conclusion: We believe that an earlier and clearer diagnosis of pulmonary cryptococcosis requires an earlier interplay of imaging, pathology, testing, and individual patient differences.
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http://dx.doi.org/10.1016/j.ijscr.2022.106973DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9093010PMC
May 2022

BBPpredict: A Web Service for Identifying Blood-Brain Barrier Penetrating Peptides.

Front Genet 2022 17;13:845747. Epub 2022 May 17.

School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.

Blood-brain barrier (BBB) is a major barrier to drug delivery into the brain in the treatment of central nervous system (CNS) diseases. Blood-brain barrier penetrating peptides (BBPs), a class of peptides that can cross BBB through various mechanisms without damaging BBB, are effective drug candidates for CNS diseases. However, identification of BBPs by experimental methods is time-consuming and laborious. To discover more BBPs as drugs for CNS disease, it is urgent to develop computational methods that can quickly and accurately identify BBPs and non-BBPs. In the present study, we created a training dataset that consists of 326 BBPs derived from previous databases and published manuscripts and 326 non-BBPs collected from UniProt, to construct a BBP predictor based on sequence information. We also constructed an independent testing dataset with 99 BBPs and 99 non-BBPs. Multiple machine learning methods were compared based on the training dataset via a nested cross-validation. The final BBP predictor was constructed based on the training dataset and the results showed that random forest (RF) method outperformed other classification algorithms on the training and independent testing dataset. Compared with previous BBP prediction tools, the RF-based predictor, named BBPpredict, performs considerably better than state-of-the-art BBP predictors. BBPpredict is expected to contribute to the discovery of novel BBPs, or at least can be a useful complement to the existing methods in this area. BBPpredict is freely available at http://i.uestc.edu.cn/BBPpredict/cgi-bin/BBPpredict.pl.
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http://dx.doi.org/10.3389/fgene.2022.845747DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9152268PMC
May 2022

Mesoporous Polyimide-Linked Covalent Organic Framework with Multiple Redox-Active Sites for High-Performance Cathodic Li Storage.

Angew Chem Int Ed Engl 2022 Aug 15;61(31):e202207043. Epub 2022 Jun 15.

Beijing Advanced Innovation Center for Materials Genome Engineering, Beijing Key Laboratory for Science and Application of Functional Molecular and Crystalline Materials, Department of Chemistry and Chemical Engineering, School of Chemistry and Biological Engineering, University of Science and Technology Beijing, Beijing, 100083, P. R. China.

Covalent organic frameworks (COFs) are gaining increasing attention as renewable cathode materials for Li-ion batteries. However, COF electrodes reported so far still exhibit unsatisfying capacity due to their limited active site density and insufficient utilization. Herein, a new two-dimensional polyimide-linked COF, HATN-AQ-COF with multiple redox-active sites for storing Li ions, was designed and fabricated from a new module of 2,3,8,9,14,15-hexacarboxyl hexaazatrinaphthalene trianhydrides with a 2,6-diaminoanthraquinone linker. HATN-AQ-COF possessing excellent stability, good conductivity, and a large pore size of 3.8 nm enables the stable and fast ion transport. This, in combination with the abundant redox active sites, results in a high reversible capacity of 319 mAh g at 0.5 C (1 C=358 mA g ) for the HATN-AQ-COF electrode with a high active site utilization of 89 % and good cycle performance, representing one of the best performances among the reported COF electrodes.
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http://dx.doi.org/10.1002/anie.202207043DOI Listing
August 2022

A minimalist and robust chemo-photothermal nanoplatform capable of augmenting autophagy-modulated immune response against breast cancer.

Mater Today Bio 2022 Jun 13;15:100289. Epub 2022 May 13.

School of Basic Medicine, Health Science Center, Yangtze University, Jingzhou, China.

Previously used in anti-fungal therapy, itraconazole has now been shown to be successful in treating advanced breast cancer (NCT00798135). However, its poor solubility still restricts its application in clinical treatment. There is therefore an urgent need for combined methods to enhance the therapeutic effect of itraconazole (IC) in breast cancer treatment. With this goal, co-assembled IC/IR820 NPs with synergistic photonic hyperthermia and itraconazole payloads have been constructed to overcome these shortcomings. The IC/IR820 NPs show an enhanced therapeutic effect on breast cancer by inducing reactive oxygen species (ROS)-mediated apoptosis and autophagic death. Further evaluation in a mouse model has shown impressive effects of the IC/IR820 NPs on both inhibiting tumor metastasis and activating immunity to prevent tumor recurrence. Mechanistically, itraconazole may promote both tumor cell antigen presentation through autophagy and the activation of dendritic cells to induce an immune response, which displays a synergistic effect with the immune response generated by photothermal therapy to inhibit tumor recurrence. This strategy of combining itraconazole and IR820 into one minimalist and robust nanoplatform through co-assembly results in excellent therapeutic efficacy, suggesting its potential application as an alternative method for the clinical treatment of breast cancer.
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http://dx.doi.org/10.1016/j.mtbio.2022.100289DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9130112PMC
June 2022

Hydrophobic Modification of Wood Using Tetramethylcyclotetrasiloxane.

Polymers (Basel) 2022 May 19;14(10). Epub 2022 May 19.

Department of Chemical Engineering and Food Science, Hubei University of Arts and Science, 296 Longzhong Road, Xiangyang 441053, China.

Hydrophobic surfaces have aroused considerable attention because of their extensive potential applications. In this work, we developed a facile strategy for fabricating hydrophobic and anti-fouling surfaces on wood substrates. The modification was accomplished simply by immerging wood into the tetramethylcyclotetrasiloxane (D4H) modifier solution for 5 min. The D4H modified wood was characterized using Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy, scanning electron microscope, and energy dispersive spectrometer. The result shows that the D4H modified wood had good hydrophobicity, and the water contact angle of wood in the radial and cross sections reached 140.1° and 152°. In addition, the obtained hydrophobic wood surface also showed anti-fouling properties, UV resistance and could withstand the tape peel test and finger wiping.
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http://dx.doi.org/10.3390/polym14102077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9144661PMC
May 2022

The Emerging Roles and Therapeutic Implications of Epigenetic Modifications in Ovarian Cancer.

Front Endocrinol (Lausanne) 2022 10;13:863541. Epub 2022 May 10.

State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, and West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu, China.

Ovarian cancer (OC) is one of the most lethal gynecologic malignancies globally. In spite of positive responses to initial therapy, the overall survival rates of OC patients remain poor due to the development of drug resistance and consequent cancer recurrence. Indeed, intensive studies have been conducted to unravel the molecular mechanisms underlying OC therapeutic resistance. Besides, emerging evidence suggests a crucial role for epigenetic modifications, namely, DNA methylation, histone modifications, and non-coding RNA regulation, in the drug resistance of OC. These epigenetic modifications contribute to chemoresistance through various mechanisms, namely, upregulating the expression of multidrug resistance proteins (MRPs), remodeling of the tumor microenvironment, and deregulated immune response. Therefore, an in-depth understanding of the role of epigenetic mechanisms in clinical therapeutic resistance may improve the outcome of OC patients. In this review, we will discuss the epigenetic regulation of OC drug resistance and propose the potential clinical implications of epigenetic therapies to prevent or reverse OC drug resistance, which may inspire novel treatment options by targeting resistance mechanisms for drug-resistant OC patients.
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http://dx.doi.org/10.3389/fendo.2022.863541DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9127157PMC
May 2022

Coupled CFD-DEM modeling to predict how EPS affects bacterial biofilm deformation, recovery and detachment under flow conditions.

Biotechnol Bioeng 2022 May 24. Epub 2022 May 24.

School of Engineering, Newcastle University, Newcastle upon Tyne, UK.

The deformation and detachment of bacterial biofilm are related to the structural and mechanical properties of the biofilm itself. Extracellular polymeric substances (EPS) play an important role on keeping the mechanical stability of biofilms. The understanding of biofilm mechanics and detachment can help to reveal biofilm survival mechanisms under fluid shear and provide insight about what flows might be needed to remove biofilm in a cleaning cycle or for a ship to remove biofilms. However, how the EPS may affect biofilm mechanics and its deformation in flow conditions remains elusive. To address this, a coupled computational fluid dynamic- discrete element method (CFD-DEM) model was developed. The mechanisms of biofilm detachment, such as erosion and sloughing have been revealed by imposing hydrodynamic fluid flow at different velocities and loading rates. The model, which also allows adjustment of the proportion of different functional groups of microorganisms in the biofilm, enables the study of the contribution of EPS toward biofilm resistance to fluid shear stress. Furthermore, the stress-strain curves during biofilm deformation have been captured by loading and unloading fluid shear stress to study the viscoelastic properties of the biofilm. Our predicted emergent viscoelastic properties of biofilms were consistent with relevant experimental measurements.
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http://dx.doi.org/10.1002/bit.28146DOI Listing
May 2022

Remediation of organic amendments on soil salinization: Focusing on the relationship between soil salts and microbial communities.

Ecotoxicol Environ Saf 2022 Jul 16;239:113616. Epub 2022 May 16.

State Key Laboratory of North China Crop Improvement and Regulation, Key Laboratory for Farmland Eco-environment of Hebei Province, Hebei Collaborative Innovation Center for Green & Efficient Vegetable Industry, College of Resources and Environmental Science, Hebei Agricultural University, Baoding 071000, China. Electronic address:

Soil salinization has emerged as a major factor with an adverse influence on agricultural green development worldwide. It is necessary to develop high-efficiency and ecologically beneficial management measures for alleviating soil salinization. The experiment of application for cow manure (CM), biochar (BC), and bio-organic fertilizer (BIO) in soil with light salinity was conducted to investigate the remediation of organic materials on soil salinization with melon (Cucumis melo L.) by reducing the availability of saline ions and shifting the soil microbial community. Results showed that BC treatment significantly decreased the EC values of the soil and soil solution by 19.23% and 27.02% and the concentrations of Na, K, and Cl by 13.28%, 13.08%, and 15.21%, respectively, followed by CM and BIO treatments. High-throughput sequencing identified that organic amendments significantly improved the richness of the soil bacterial community and increased the relative abundances of Acidobacteria and Firmicutes by 33.11% and 111.2%, respectively, and the beneficial salt-tolerant bacterial genera Flavobacterium, Bacillus and Arthrobacter by 32.04%, 38.92% and 35.67%, respectively. Additionally, soil Na, Ca, K and Cl were significantly negatively correlated with Acidobacteria and Flavobacterium and were also the most important factors driving the changes in the structure of the soil bacterial communities. The bacterial networks were more complex in the organic amendments treatments than in CK, reflecting through more nodes and links and a higher average clustering coefficient, density and modularity. This study provided a comprehensive understanding of the application of organic amendments in alleviating soil salinization and improving soil bacterial and fungal communities and provides scientific support for agriculture green development.
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http://dx.doi.org/10.1016/j.ecoenv.2022.113616DOI Listing
July 2022
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