Publications by authors named "Boris C Bastian"

100Publications

Functional characterization of uveal melanoma oncogenes.

Oncogene 2020 Dec 1. Epub 2020 Dec 1.

Departments of Dermatology and Pathology and Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, 94143, USA.

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December 2020

Eruptive Spitz nevus, a striking example of benign metastasis.

Sci Rep 2020 10 1;10(1):16216. Epub 2020 Oct 1.

Department of Dermatology, University of California San Francisco, 1701 Divisadero St. Ste. 280, San Francisco, CA, 94143, USA.

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October 2020

Author Correction: From melanocytes to melanomas.

Nat Rev Cancer 2020 Jun;20(6):355

University of California, San Francisco, Departments of Dermatology and Pathology and Helen Diller Family Comprehensive Cancer Center, Box 3111, San Francisco, CA, 94143, USA.

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June 2020

Next-Generation Sequencing of Retinoblastoma Identifies Pathogenic Alterations beyond RB1 Inactivation That Correlate with Aggressive Histopathologic Features.

Ophthalmology 2020 06 12;127(6):804-813. Epub 2019 Dec 12.

Department of Ophthalmology, University of California, San Francisco, San Francisco, California; Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom.

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June 2020

The 2018 World Health Organization Classification of Cutaneous, Mucosal, and Uveal Melanoma: Detailed Analysis of 9 Distinct Subtypes Defined by Their Evolutionary Pathway.

Arch Pathol Lab Med 2020 04 14;144(4):500-522. Epub 2020 Feb 14.

From the Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia (Dr Elder); the Department of Dermatology, University of California San Francisco, San Francisco (Dr Bastian); International Agency for Research on Cancer, Lyon, France (Dr Cree); Section of Anatomic Pathology, Department of Health Sciences, University of Florence, Florence, Italy (Dr Massi); and the Department of Pathology and Melanoma Institute Australia, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia (Dr Scolyer).

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April 2020

Spitz melanoma is a distinct subset of spitzoid melanoma.

Mod Pathol 2020 06 3;33(6):1122-1134. Epub 2020 Jan 3.

Departments of Pathology and Dermatology, University of California San Francisco, San Francisco, CA, USA.

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June 2020

Ewing sarcoma in a child with neurofibromatosis type 1.

Cold Spring Harb Mol Case Stud 2019 10 23;5(5). Epub 2019 Oct 23.

Division of Hematology and Oncology, Department of Pediatrics, University of California, San Francisco, San Francisco, California 94158, USA.

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October 2019

Genetic Heterogeneity of BRAF Fusion Kinases in Melanoma Affects Drug Responses.

Cell Rep 2019 10;29(3):573-588.e7

Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94158, USA; Department of Dermatology, University of California, San Francisco, San Francisco, CA 94115, USA; Department of Pathology, University of California, San Francisco, San Francisco, CA 94115, USA. Electronic address:

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October 2019

MicroRNA Ratios Distinguish Melanomas from Nevi.

J Invest Dermatol 2020 01 30;140(1):164-173.e7. Epub 2019 Sep 30.

Department of Dermatology, University of California, San Francisco, California, USA; Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah, USA; Department of Dermatology, University of Utah School of Medicine, Salt Lake City, Utah, USA. Electronic address:

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January 2020

Melanoma to Vitiligo: The Melanocyte in Biology & Medicine-Joint Montagna Symposium on the Biology of Skin/PanAmerican Society for Pigment Cell Research Annual Meeting.

J Invest Dermatol 2020 02 23;140(2):269-274. Epub 2019 Jul 23.

Department of Dermatology, Oregon Health & Science University, Portland, Oregon; Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon; Department of Cell, Developmental & Cancer Biology, Oregon Health & Science University, Portland, Oregon. Electronic address:

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February 2020

The genetic evolution of metastatic uveal melanoma.

Nat Genet 2019 07 28;51(7):1123-1130. Epub 2019 Jun 28.

Department of Ophthalmology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.

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July 2019

Next-Generation Sequencing of Uveal Melanoma for Detection of Genetic Alterations Predicting Metastasis.

Transl Vis Sci Technol 2019 Mar 17;8(2):18. Epub 2019 Apr 17.

Hellen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA.

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March 2019

Human tumor genomics and zebrafish modeling identify loss as a driver of mucosal melanoma.

Science 2018 11 1;362(6418):1055-1060. Epub 2018 Nov 1.

Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94158, USA.

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November 2018

Bi-allelic Loss of CDKN2A Initiates Melanoma Invasion via BRN2 Activation.

Cancer Cell 2018 07;34(1):56-68.e9

Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA 94143, USA; Department of Dermatology, University of California San Francisco, San Francisco, CA 94115, USA. Electronic address:

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July 2018

Genomic and Transcriptomic Analysis Reveals Incremental Disruption of Key Signaling Pathways during Melanoma Evolution.

Cancer Cell 2018 07;34(1):45-55.e4

University of California San Francisco, Department of Dermatology, San Francisco, CA, USA; University of California San Francisco, Helen Diller Comprehensive Cancer Center, San Francisco, CA, USA; University of California San Francisco, Department of Pathology, San Francisco, CA, USA. Electronic address:

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July 2018

Mutations in the promoter of the telomerase gene contribute to tumorigenesis by a two-step mechanism.

Science 2017 09 17;357(6358):1416-1420. Epub 2017 Aug 17.

Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.

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September 2017

Filling the gaps in the genomic catalogue of melanoma subtypes.

Pigment Cell Melanoma Res 2017 01 21;30(6):508-509. Epub 2017 Oct 21.

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January 2017

RasGRP3 Mediates MAPK Pathway Activation in GNAQ Mutant Uveal Melanoma.

Cancer Cell 2017 05;31(5):685-696.e6

Departments of Dermatology and Pathology, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address:

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May 2017

Multiple Merkel cell carcinomas: Late metastasis or multiple primary tumors? A molecular study.

JAAD Case Rep 2017 Mar 20;3(2):131-134. Epub 2017 Mar 20.

Department of Dermatology, University Hospitals Case Medical Center, Cleveland, Ohio.

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March 2017

Activating NRF1-BRAF and ATG7-RAF1 fusions in anaplastic pleomorphic xanthoastrocytoma without BRAF p.V600E mutation.

Acta Neuropathol 2016 11 13;132(5):757-760. Epub 2016 Sep 13.

Division of Medical Genetics, Department of Pediatrics, University of California San Francisco, San Francisco, CA, USA.

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November 2016

From melanocytes to melanomas.

Nat Rev Cancer 2016 06 29;16(6):345-58. Epub 2016 Apr 29.

University of California, San Francisco, Departments of Dermatology and Pathology and Helen Diller Family Comprehensive Cancer Center, Box 3111, San Francisco, CA 94143, USA.

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June 2016

CNVkit: Genome-Wide Copy Number Detection and Visualization from Targeted DNA Sequencing.

PLoS Comput Biol 2016 Apr 21;12(4):e1004873. Epub 2016 Apr 21.

Department of Dermatology, University of California, San Francisco, San Francisco, California, United States of America.

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April 2016

Inactivating MUTYH germline mutations in pediatric patients with high-grade midline gliomas.

Neuro Oncol 2016 05 21;18(5):752-3. Epub 2016 Feb 21.

Division of Pediatric Hematology/Oncology, Department of Pediatrics, University of California, San Francisco, California (C.N.K., S.M.); Clinical Cancer Genomics Laboratory, University of California, San Francisco, California (N.M.J., J.P.G., J.v.Z., I.Y., B.C.B.); Departments of Neurology and Neurosurgery, University of California, San Francisco, California (S.M.); Division of Neuropathology, Department of Pathology, University of California, San Francisco, California (D.A.S.).

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May 2016

The Genetic Evolution of Melanoma from Precursor Lesions.

N Engl J Med 2015 Nov;373(20):1926-36

From the Departments of Dermatology and Pathology (A.H.S., I.Y., E.T., A.G., J.N., L.P., B.R., B.C.B.) and the Helen Diller Family Comprehensive Cancer Center (A.H.S., I.Y., E.T., A.G., B.C.B.), University of California, San Francisco (UCSF), San Francisco; the Departments of Dermatology and Pathology, Cleveland Clinic, Cleveland (I.K.); the Department of Pathology, Orlando Health, Orlando, FL (A.S.); the Department of Dermatology, University Hospital of Zurich, Zurich, Switzerland (R.D.); and the Department of Dermatology, Dorset County Hospital, Dorchester (C.D.), and the Department of Dermatology, St. John's Institute of Dermatology, London (W.R., A.R.) - both in the United Kingdom.

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November 2015

Congenital uveal melanoma?

Surv Ophthalmol 2016 Jan-Feb;61(1):59-64. Epub 2015 Aug 12.

Anatomic Pathology, Cleveland Clinic, Cleveland, Ohio, USA.

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September 2016

Clinical activity of the MEK inhibitor trametinib in metastatic melanoma containing BRAF kinase fusion.

Pigment Cell Melanoma Res 2015 Sep 3;28(5):607-10. Epub 2015 Jul 3.

Melanoma Institute Australia, Sydney, NSW, Australia.

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September 2015

Activating MET kinase rearrangements in melanoma and Spitz tumours.

Nat Commun 2015 May 27;6:7174. Epub 2015 May 27.

1] Departments of Dermatology and Pathology, and Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, California 94143, USA [2] Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, California 94143, USA.

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May 2015

Clinical, histopathologic, and genomic features of Spitz tumors with ALK fusions.

Am J Surg Pathol 2015 May;39(5):581-91

*Departments of Dermatology and Pathology, University of California, San Francisco, CA ‡Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY †Department of Biopathologie, Centre Leon Berard, Leon, France.

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May 2015

Melanoma BRAF fusions--letter.

Clin Cancer Res 2014 Dec;20(24):6631

Departments of Dermatology and Pathology and Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, California.

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December 2014

Metastatic melanoma in association with a giant congenital melanocytic nevus in an adult: controversial CGH findings.

Am J Dermatopathol 2015 Jun;37(6):487-94

Departments of *Dermatology, and †Pathology, Fundación Jiménez Díaz, Universidad Autónoma, Madrid, Spain; and ‡Departments of Dermatology and Pathology, and the UCSF Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA.

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June 2015

Mutant Gq/11 promote uveal melanoma tumorigenesis by activating YAP.

Cancer Cell 2014 Jun 29;25(6):822-30. Epub 2014 May 29.

Department of Pharmacology and Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address:

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June 2014

Ambiguous melanocytic tumors with loss of 3p21.

Am J Surg Pathol 2014 Aug;38(8):1088-95

Departments of *Dermatology †Pathology, University of California, San Francisco ‡Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, NY.

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August 2014

Fluorescence in situ hybridization as an ancillary tool in the diagnosis of ambiguous melanocytic neoplasms: a review of 804 cases.

Am J Surg Pathol 2014 Jun;38(6):824-31

Departments of *Pathology †Dermatology ‡The Helen Diller Comprehensive Cancer Center, University of California, San Francisco, CA.

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June 2014

The molecular pathology of melanoma: an integrated taxonomy of melanocytic neoplasia.

Authors:
Boris C Bastian

Annu Rev Pathol 2014 ;9:239-71

Departments of Dermatology and Pathology, Cardiovascular Research Institute, University of California, San Francisco, California 94158-9001; email:

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March 2014

Chromosomal copy number analysis in melanoma diagnostics.

Methods Mol Biol 2014 ;1102:199-226

Department of Dermatology, University of California San Francisco, San Francisco, CA, USA.

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June 2014

Targeting activated KIT signaling for melanoma therapy.

J Clin Oncol 2013 Sep 12;31(26):3288-90. Epub 2013 Aug 12.

University of California at San Francisco, San Francisco, CA.

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September 2013

SOX10 ablation arrests cell cycle, induces senescence, and suppresses melanomagenesis.

Cancer Res 2013 Sep 1;73(18):5709-18. Epub 2013 Aug 1.

Authors' Affiliations: Genetic Disease Research Branch, National Human Genome Research Institute, Bethesda, Maryland; Maryland Melanoma Center at Medstar Franklin Square Medical Center, Baltimore, Maryland; Department of Dermatology, University Hospital of Zurich, Zurich, Switzerland; Queensland Institute of Medical Research, Oncogenomics Laboratory, Brisbane, Australia; and Helen Diller Family Comprehensive Cancer Center, UCSF, San Francisco, CA.

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September 2013

MC1R and cAMP signaling inhibit cdc25B activity and delay cell cycle progression in melanoma cells.

Proc Natl Acad Sci U S A 2013 Aug 1;110(34):13845-50. Epub 2013 Aug 1.

Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA 94115, USA.

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August 2013

Recurrent BRAF kinase fusions in melanocytic tumors offer an opportunity for targeted therapy.

Pigment Cell Melanoma Res 2013 Nov 19;26(6):845-51. Epub 2013 Aug 19.

Departments of Dermatology and Pathology and Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, USA.

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November 2013

Allele-specific imbalance mapping identifies HDAC9 as a candidate gene for cutaneous squamous cell carcinoma.

Int J Cancer 2014 Jan 16;134(1):244-8. Epub 2013 Jul 16.

Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, Columbus, OH; The Ohio State University Comprehensive Cancer Center, Columbus, OH.

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January 2014

Clonal BRAF mutations in melanocytic nevi and initiating role of BRAF in melanocytic neoplasia.

J Natl Cancer Inst 2013 Jun 20;105(12):917-9. Epub 2013 May 20.

Department of Dermatology, University of California, San Francisco, USA.

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June 2013

A distinct subset of atypical Spitz tumors is characterized by BRAF mutation and loss of BAP1 expression.

Am J Surg Pathol 2012 Jun;36(6):818-30

Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.

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June 2012

Sunitinib therapy for melanoma patients with KIT mutations.

Clin Cancer Res 2012 Mar 18;18(5):1457-63. Epub 2012 Jan 18.

California Pacific Center for Melanoma Research and Treatment, University of California San Francisco, San Francisco, California, USA.

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March 2012

An unconventional deep penetrating melanocytic nevus with microscopic involvement of regional lymph nodes.

J Cutan Pathol 2012 Jan;39(1):25-8

Department of Pathology, University of California, San Francisco, CA, USA.

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January 2012

An isolated Merkel cell carcinoma metastasis at a distant cutaneous site presenting as a second 'primary' tumor.

J Cutan Pathol 2011 Oct 23;38(10):801-7. Epub 2011 Aug 23.

Department of Dermatology, University of California San Francisco, San Francisco, CA, USA.

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October 2011

Metastatic melanoma with striking adenocarcinomatous differentiation illustrating phenotypic plasticity in melanoma.

Am J Surg Pathol 2011 Sep;35(9):1413-8

Department of Pathology, University of California at San Francisco, San Francisco, CA, USA.

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September 2011

Beyond BRAF in melanoma.

Curr Top Microbiol Immunol 2012 ;355:99-117

University of California, San Francisco, CA 94143, USA.

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August 2014

The melanomas: a synthesis of epidemiological, clinical, histopathological, genetic, and biological aspects, supporting distinct subtypes, causal pathways, and cells of origin.

Pigment Cell Melanoma Res 2011 Oct 16;24(5):879-97. Epub 2011 Aug 16.

Cancer Control Group, Queensland Institute of Medical Research, Brisbane, Qld, Australia.

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October 2011

Molecular-microscopical correlation in dermatopathology.

J Cutan Pathol 2011 Apr;38(4):324-6, 323

University of California, San Francisco, CA, USA.

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April 2011

Loss of the p53/p63 regulated desmosomal protein Perp promotes tumorigenesis.

PLoS Genet 2010 Oct 21;6(10):e1001168. Epub 2010 Oct 21.

Department of Radiation Oncology, Division of Radiation and Cancer Biology, Stanford University School of Medicine, Stanford, California, USA.

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October 2010

Germline variation controls the architecture of somatic alterations in tumors.

PLoS Genet 2010 Sep 23;6(9):e1001136. Epub 2010 Sep 23.

Integrated Biomedical Sciences Graduate Program, The Ohio State University, Columbus, Ohio, United States of America.

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September 2010

Mutation-driven drug development in melanoma.

Curr Opin Oncol 2010 May;22(3):178-83

Massachusetts General Hospital Cancer Center, Boston, MA 02114, USA.

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May 2010