Mrs. Boel De Paepe, PhD - Ghent University Hospital - research expert

Mrs. Boel De Paepe

PhD

Ghent University Hospital

research expert

Belgium

Main Specialties: Other

Additional Specialties: muscle disease

Mrs. Boel De Paepe, PhD - Ghent University Hospital - research expert

Mrs. Boel De Paepe

PhD

Introduction

Primary Affiliation: Ghent University Hospital - Belgium

Specialties:

Additional Specialties:

Publications

57Publications

2349Reads

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432PubMed Central Citations

Rare variants in SQSTM1 and VCP genes and risk of sporadic inclusion body myositis.

Neurobiol Aging 2016 11 8;47:218.e1-218.e9. Epub 2016 Aug 8.

Department of Molecular Neuroscience, Institute of Neurology, University College London, Queen Square, London, UK; MRC Centre for Neuromuscular Diseases, Institute of Neurology, University College London, Queen Square, London, UK; Neurogenetics Laboratory, Institute of Neurology, University College London, Queen Square, London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2016.07.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5082791PMC
November 2016
63 Reads
4 Citations
5.013 Impact Factor

Activation of osmolyte pathways in inflammatory myopathy and Duchenne muscular dystrophy points to osmoregulation as a contributing pathogenic mechanism.

Lab Invest 2016 08 20;96(8):872-84. Epub 2016 Jun 20.

Department of Neurology, Neuromuscular Reference Center, Ghent University Hospital, Ghent, Belgium.

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http://dx.doi.org/10.1038/labinvest.2016.68DOI Listing
August 2016
28 Reads
3 Citations
3.680 Impact Factor

A bumpy ride on the diagnostic bench of massive parallel sequencing, the case of the mitochondrial genome.

PLoS One 2014 10;9(11):e112950. Epub 2014 Nov 10.

Research Group Reproduction and Genetics (REGE), Vrije Universiteit Brussel (VUB), Brussels, Belgium; Center for Medical Genetics, UZ Brussel, Vrije Universiteit Brussel (VUB), Brussels, Belgium.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0112950PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4226615PMC
December 2015
132 Reads
2 Citations
3.234 Impact Factor

Scanning for Therapeutic Targets within the Cytokine Network of Idiopathic Inflammatory Myopathies.

Int J Mol Sci 2015 Aug 11;16(8):18683-713. Epub 2015 Aug 11.

Department of Neurology, University Medical Centre, Göttingen University, 37075 Göttingen, Germany.

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http://dx.doi.org/10.3390/ijms160818683DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4581266PMC
August 2015
6 Reads
4 Citations
2.862 Impact Factor

Interferons as components of the complex web of reactions sustaining inflammation in idiopathic inflammatory myopathies.

Authors:
Boel De Paepe

Cytokine 2015 Jul 4;74(1):81-7. Epub 2014 Dec 4.

Department of Neurology, Myopathology & Neuromuscular Reference Centre, Ghent University Hospital, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.cyto.2014.10.012DOI Listing
July 2015
12 Reads
3 Citations
2.664 Impact Factor

The effects of an intronic polymorphism in TOMM40 and APOE genotypes in sporadic inclusion body myositis.

Neurobiol Aging 2015 Apr 14;36(4):1766.e1-1766.e3. Epub 2015 Jan 14.

Department of Molecular Neuroscience, Institute of Neurology, University College London, London, UK; Medical Research Council Centre for Neuromuscular Diseases, Institute of Neurology, University College London, London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2014.12.039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4378665PMC
April 2015
50 Reads
4 Citations
5.013 Impact Factor

Possible pathogenic mechanism of propofol infusion syndrome involves coenzyme q.

Anesthesiology 2015 Feb;122(2):343-52

From the Department of Pediatrics, Division of Pediatric Neurology and Metabolism (A.V.V., J.S., E.D.L., B.D.P., R.V.C.), Department of Critical Care Medicine, Division of Pediatric Intensive Care Medicine (A.d.J.), Department of Clinical Chemistry (B.W.), Department of Emergency Medicine (P.D.P.), Ghent University Hospital, Ghent, Belgium; Department of General Pediatrics, Division of Inherited Metabolic Diseases, University Children's Hospital, Heidelberg, Germany (J.G.O.); Department of Pediatrics, University of Ghent, Ghent, Belgium (G.D.); Physiology Group, Department of Basic Medical Sciences, Ghent University, Ghent, Belgium (B.V.); Department of Critical Care Medicine, Antwerp University Hospital, Antwerp University, Edegem, Belgium (P.G.J., N.V.R.); and Department of Critical Care Medicine, ZNA Antwerp, Belgium (N.V.R.).

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http://dx.doi.org/10.1097/ALN.0000000000000484DOI Listing
February 2015
135 Reads
11 Citations
5.880 Impact Factor

Analysis of the whole mitochondrial genome: translation of the Ion Torrent Personal Genome Machine system to the diagnostic bench?

Eur J Hum Genet 2015 Jan 26;23(1):41-8. Epub 2014 Mar 26.

1] Research Group Reproduction and Genetics, Vrije Universiteit Brussel (VUB), Brussels, Belgium [2] Department of Pediatric Neurology, UZ Brussel, Vrije Universiteit Brussel (VUB), Brussels, Belgium.

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http://dx.doi.org/10.1038/ejhg.2014.49DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4266735PMC
January 2015
44 Reads
8 Citations
4.350 Impact Factor

Cytokines and chemokines as regulators of skeletal muscle inflammation: presenting the case of Duchenne muscular dystrophy.

Mediators Inflamm 2013 5;2013:540370. Epub 2013 Nov 5.

Laboratory for Myopathology, Department of Neurology and Neuromuscular Reference Center, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium.

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http://www.hindawi.com/journals/mi/2013/540370/
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http://dx.doi.org/10.1155/2013/540370DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3835490PMC
June 2014
24 Reads
22 Citations
3.240 Impact Factor

Effect of resveratrol on cultured skin fibroblasts from patients with oxidative phosphorylation defects.

Phytother Res 2014 Feb 26;28(2):312-6. Epub 2013 Apr 26.

Department of Pediatrics, Division of Pediatric Neurology and Metabolism, Ghent University Hospital, Ghent, Belgium.

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http://dx.doi.org/10.1002/ptr.4988DOI Listing
February 2014
18 Reads
5 Citations
2.400 Impact Factor

Heat-shock proteins in autoimmunity.

Autoimmune Dis 2013 19;2013:621417. Epub 2013 May 19.

Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.

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http://dx.doi.org/10.1155/2013/621417DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3671508PMC
June 2013
7 Reads
5 Citations

Unraveling the mechanisms behind the enhanced MTT conversion by irradiated breast cancer cells.

Radiat Res 2013 Apr 6;179(4):433-43. Epub 2013 Mar 6.

Department of Radiation Oncology and Experimental Cancer Research, Ghent University Hospital, Belgium.

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http://dx.doi.org/10.1667/RR3070.1DOI Listing
April 2013
14 Reads
3 Citations
2.911 Impact Factor

The nonnecrotic invaded muscle fibers of polymyositis and sporadic inclusion body myositis: on the interplay of chemokines and stress proteins.

Neurosci Lett 2013 Feb 4;535:18-23. Epub 2013 Jan 4.

Laboratory for Myopathology, Department of Neurology and Neuromuscular Reference Center, Ghent University Hospital, Belgium.

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http://dx.doi.org/10.1016/j.neulet.2012.11.064DOI Listing
February 2013
13 Reads
5 Citations
2.060 Impact Factor

Upregulation of chemokines and their receptors in Duchenne muscular dystrophy: potential for attenuation of myofiber necrosis.

Muscle Nerve 2012 Dec;46(6):917-25

Laboratory for Myopathology, Department of Neurology and Neuromuscular Reference Center, Ghent University Hospital, De Pintelaan 185, B-9000 Ghent, Belgium.

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http://dx.doi.org/10.1002/mus.23481DOI Listing
December 2012
25 Reads
14 Citations
2.283 Impact Factor

Fluorescence imaging of mitochondria in cultured skin fibroblasts: a useful method for the detection of oxidative phosphorylation defects.

Pediatr Res 2012 Sep 22;72(3):232-40. Epub 2012 Jun 22.

Department of Pediatrics, Division of Pediatric Neurology and Metabolism, Ghent University Hospital, Ghent, Belgium.

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http://dx.doi.org/10.1038/pr.2012.84DOI Listing
September 2012
29 Reads
4 Citations
2.314 Impact Factor

Proteomic analysis in giant axonal neuropathy: new insights into disease mechanisms.

Muscle Nerve 2012 Aug;46(2):246-56

Department of Pediatrics, Division of Pediatric Neurology and Metabolism, Ghent University Hospital, De Pintelaan 185, B-9000 Ghent, Belgium.

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http://dx.doi.org/10.1002/mus.23306DOI Listing
August 2012
27 Reads
3 Citations
2.283 Impact Factor

The multifaceted character of lymphotoxin β in inflammatory myopathies and muscular dystrophies.

Neuromuscul Disord 2012 Aug 30;22(8):712-9. Epub 2012 May 30.

Laboratory for Neuropathology, Department of Neurology, Ghent University Hospital, Ghent, Belgium.

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http://dx.doi.org/10.1016/j.nmd.2012.04.012DOI Listing
August 2012
39 Reads
6 Citations
2.640 Impact Factor

The tumor necrosis factor superfamily of cytokines in the inflammatory myopathies: potential targets for therapy.

Clin Dev Immunol 2012 23;2012:369432. Epub 2011 Oct 23.

Laboratory for Myopathology, Department of Neurology and Neuromuscular Reference Center, Ghent University Hospital, 9000 Ghent, Belgium.

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http://dx.doi.org/10.1155/2012/369432DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3202109PMC
March 2012
18 Reads
10 Citations
2.934 Impact Factor

Heat shock protein families 70 and 90 in Duchenne muscular dystrophy and inflammatory myopathy: balancing muscle protection and destruction.

Neuromuscul Disord 2012 Jan 19;22(1):26-33. Epub 2011 Aug 19.

Department of Neurology and Neuromuscular Reference Center, Ghent University Hospital, Belgium.

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http://dx.doi.org/10.1016/j.nmd.2011.07.007DOI Listing
January 2012
32 Reads
11 Citations
2.640 Impact Factor

Hashimoto encephalopathy and antibodies against dimethylargininase-1: a rare cause of cognitive decline in a pediatric Down's syndrome patient.

Clin Neurol Neurosurg 2011 Oct 14;113(8):678-9. Epub 2011 May 14.

Department of Pediatric Neurology, Ghent University Hospital, De Pintelaan 185, B-9000 Gent, Belgium.

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http://dx.doi.org/10.1016/j.clineuro.2011.04.004DOI Listing
October 2011
73 Reads
1.250 Impact Factor

Complex III staining in blue native polyacrylamide gels.

J Inherit Metab Dis 2011 Jun 12;34(3):741-7. Epub 2011 Apr 12.

Department of Pediatrics, Division of Pediatric Neurology and Metabolism, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium.

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http://link.springer.com/content/pdf/10.1007/s10545-011-9315
Web Search
http://link.springer.com/10.1007/s10545-011-9315-7
Publisher Site
http://dx.doi.org/10.1007/s10545-011-9315-7DOI Listing
June 2011
46 Reads
5 Citations
3.370 Impact Factor

Anti-NMDA-receptor encephalitis in a 3 year old patient with chromosome 6p21.32 microdeletion including the HLA cluster.

Eur J Paediatr Neurol 2011 Mar 6;15(2):163-6. Epub 2010 Aug 6.

Department of Paediatric Neurology, Ghent University Hospital, De Pintelaan 185, B-9000 Gent, Belgium.

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https://linkinghub.elsevier.com/retrieve/pii/S10903798100012
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http://dx.doi.org/10.1016/j.ejpn.2010.07.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3086678PMC
March 2011
19 Reads
5 Citations
1.934 Impact Factor

Role of cytokines and chemokines in idiopathic inflammatory myopathies.

Curr Opin Rheumatol 2009 Nov;21(6):610-6

Department of Neurology and Neuromuscular Reference Center, Laboratory for Myopathology, Ghent University Hospital, Ghent, Belgium.

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http://pdfs.journals.lww.com/co-rheumatology/2009/11000/Role
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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
Publisher Site
http://dx.doi.org/10.1097/BOR.0b013e3283317b31DOI Listing
November 2009
57 Reads
28 Citations
4.890 Impact Factor

Subcomplexes of mitochondrial complex V reveal mutations in mitochondrial DNA.

Electrophoresis 2009 Oct;30(20):3565-72

Department of Paediatrics, Division of Paediatric Neurology and Metabolism, University Hospital Ghent, Ghent, Belgium.

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http://doi.wiley.com/10.1002/elps.200900213
Publisher Site
http://dx.doi.org/10.1002/elps.200900213DOI Listing
October 2009
33 Reads
6 Citations
3.030 Impact Factor

Histochemical methods for the diagnosis of mitochondrial diseases.

Curr Protoc Hum Genet 2009 Oct;Chapter 19:Unit19.2

Department of Pediatrics, Division of Child Neurology and Metabolism, and Neuromuscular Reference Center, Ghent University Hospital, Ghent, Belgium.

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http://dx.doi.org/10.1002/0471142905.hg1902s63DOI Listing
October 2009
17 Reads
5 Citations

A dual role for HSP90 and HSP70 in the inflammatory myopathies: from muscle fiber protection to active invasion by macrophages.

Ann N Y Acad Sci 2009 Sep;1173:463-9

Department of Neurology, Ghent University Hospital, Ghent, Belgium.

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http://dx.doi.org/10.1111/j.1749-6632.2009.04812.xDOI Listing
September 2009
20 Reads
3 Citations
4.313 Impact Factor

Distribution of the NF-kappaB complex in the inflammatory exudates characterizing the idiopathic inflammatory myopathies.

Ann N Y Acad Sci 2009 Sep;1173:370-7

Department of Neurology, Ghent University Hospital, Belgium.

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http://dx.doi.org/10.1111/j.1749-6632.2009.04874.xDOI Listing
September 2009
35 Reads
5 Citations
4.313 Impact Factor

Idiopathic inflammatory myopathies and the classical NF-kappaB complex: current insights and implications for therapy.

Autoimmun Rev 2009 Jun 20;8(7):627-31. Epub 2009 Feb 20.

Department of Neurology, Ghent University Hospital, Belgium.

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http://dx.doi.org/10.1016/j.autrev.2009.02.026DOI Listing
June 2009
25 Reads
3 Citations
7.933 Impact Factor

Anti-angiogenic agents and cancer: current insights and future perspectives.

Authors:
Boel De Paepe

Recent Pat Anticancer Drug Discov 2009 Jun;4(2):180-5

Ghent University Hospital, Neurology and Pathology, UZ 1K12A, De Pintelaan 185, 9000 Ghent, Belgium.

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http://dx.doi.org/10.2174/157489209788452821DOI Listing
June 2009
15 Reads
4 Citations
4.295 Impact Factor

TNF alpha receptor genotype influences smoking-induced muscle-fibre-type shift and atrophy in mice.

Acta Neuropathol 2008 Jun 29;115(6):675-81. Epub 2008 Feb 29.

Department of Neurology, Ghent University Hospital, UZ 1K12A, De Pintelaan 185, 9000 Ghent, Belgium.

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http://dx.doi.org/10.1007/s00401-008-0348-4DOI Listing
June 2008
18 Reads
6 Citations
10.762 Impact Factor

Chemokines in idiopathic inflammatory myopathies.

Front Biosci 2008 Jan 1;13:2548-77. Epub 2008 Jan 1.

Department of Neurology, Ghent University Hospital, Ghent, Belgium.

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http://dx.doi.org/10.2741/2866DOI Listing
January 2008
9 Reads
13 Citations

Two novel mitochondrial DNA mutations in muscle tissue of a patient with limb-girdle myopathy.

Arch Neurol 2007 Sep;64(9):1339-43

Center for Medical Genetics, Vrije Universiteit Brussel, Laarbeeklaan 101, 1090 Brussels, Belgium.

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http://dx.doi.org/10.1001/archneur.64.9.1339DOI Listing
September 2007
28 Reads
1 Citation
7.420 Impact Factor

Chemokine profile of different inflammatory myopathies reflects humoral versus cytotoxic immune responses.

Ann N Y Acad Sci 2007 Aug;1109:441-53

Department of Neurology, Ghent University Hospital, Belgium.

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http://dx.doi.org/10.1196/annals.1398.050DOI Listing
August 2007
20 Reads
8 Citations
4.313 Impact Factor

Distribution of glucocorticoid receptor alpha and beta subtypes in the idiopathic inflammatory myopathies.

Neuromuscul Disord 2007 Feb 23;17(2):186-93. Epub 2007 Jan 23.

Department of Neurology, Ghent University Hospital, De Pintelaan 185, B-9000 Gent, Belgium.

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http://dx.doi.org/10.1016/j.nmd.2006.11.004DOI Listing
February 2007
40 Reads
2.640 Impact Factor

A new family with the mitochondrial tRNAGLU gene mutation m.14709T>C presenting with hydrops fetalis.

Eur J Paediatr Neurol 2007 Jan 11;11(1):17-20. Epub 2006 Dec 11.

Center for Medical Genetics, Neurology AZ-VUB, Dutch-speaking Free University of Brussels, Brussels, Belgium.

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http://dx.doi.org/10.1016/j.ejpn.2006.10.004DOI Listing
January 2007
20 Reads
2 Citations
1.934 Impact Factor

Potential therapeutic targets for idiopathic inflammatory myopathies.

Drug News Perspect 2006 Nov;19(9):549-57

Department of Neurology, Ghent University Hospital, Ghent, Belgium.

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http://dx.doi.org/10.1358/dnp.2006.19.9.1050424DOI Listing
November 2006
12 Reads
1 Citation

A novel mitochondrial transfer RNA(Asn) mutation causing multiorgan failure.

Arch Neurol 2006 Aug;63(8):1194-8

Center for Medical Genetics, Dutch-Speaking Free University of Brussels, Laarbeeklaan 101, 1090 Brussels, Belgium.

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http://dx.doi.org/10.1001/archneur.63.8.1194DOI Listing
August 2006
34 Reads
5 Citations
7.420 Impact Factor

Diagnostic value of immunostaining in cultured skin fibroblasts from patients with oxidative phosphorylation defects.

Pediatr Res 2006 Jan 2;59(1):2-6. Epub 2005 Dec 2.

Department of Pediatrics, Ghent University Hospital, Belgium.

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http://dx.doi.org/10.1203/01.pdr.0000191294.34122.abDOI Listing
January 2006
41 Reads
5 Citations
2.314 Impact Factor

High-dose statins and skeletal muscle metabolism in humans: a randomized, controlled trial.

Clin Pharmacol Ther 2005 Jul;78(1):60-8

Department of Internal Medicine, University Hospital of Tampere, Finland.

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http://dx.doi.org/10.1016/j.clpt.2005.03.006DOI Listing
July 2005
33 Reads
40 Citations
7.903 Impact Factor

Alpha-chemokine receptors CXCR1-3 and their ligands in idiopathic inflammatory myopathies.

Acta Neuropathol 2005 Jun 4;109(6):576-82. Epub 2005 Jun 4.

Department of Neurology, Ghent University Hospital, De Pintelaan 185, 9000, Ghent, Belgium.

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http://dx.doi.org/10.1007/s00401-005-0989-5DOI Listing
June 2005
25 Reads
11 Citations
10.762 Impact Factor

Beta-chemokine receptor expression in idiopathic inflammatory myopathies.

Muscle Nerve 2005 May;31(5):621-7

Department of Neurology, Neuromuscular Laboratory, Ghent University Hospital, De Pintelaan 185, B-9000 Ghent, Belgium.

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http://dx.doi.org/10.1002/mus.20294DOI Listing
May 2005
25 Reads
5 Citations
2.283 Impact Factor

Expression and distribution of the nitric oxide synthases in idiopathic inflammatory myopathies.

Acta Neuropathol 2004 Jul 8;108(1):37-42. Epub 2004 May 8.

Department of Neurology, Ghent University Hospital, De Pintelaan 185, 9000, Belgium.

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http://dx.doi.org/10.1007/s00401-004-0859-6DOI Listing
July 2004
9 Reads
3 Citations
10.762 Impact Factor

Localization of the alpha-chemokine SDF-1 and its receptor CXCR4 in idiopathic inflammatory myopathies.

Neuromuscul Disord 2004 Apr;14(4):265-73

Department of Neurology, Ghent University Hospital, De Pintelaan 185, B-9000 Ghent, Belgium.

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http://dx.doi.org/10.1016/j.nmd.2004.01.001DOI Listing
April 2004
43 Reads
7 Citations
2.640 Impact Factor

Differential expression of chemokines in inflammatory myopathies.

Neurology 2002 Jun;58(12):1779-85

Department of Neurology, University Hospital, Gent, Belgium.

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http://www.neurology.org/content/58/12/1779.full.pdf
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http://dx.doi.org/10.1212/wnl.58.12.1779DOI Listing
June 2002
50 Reads
12 Citations
8.290 Impact Factor

Increased angiotensin II type-2 receptor density in hyperplasia, DCIS and invasive carcinoma of the breast is paralleled with increased iNOS expression.

Histochem Cell Biol 2002 Jan 22;117(1):13-9. Epub 2001 Dec 22.

N. Goormaghtigh Institute of Pathology, University Hospital, De Pintelaan 185, 9000 Ghent, Belgium.

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http://dx.doi.org/10.1007/s00418-001-0356-0DOI Listing
January 2002
12 Reads
10 Citations
3.054 Impact Factor

Top co-authors

Boel De Paepe
Boel De Paepe

Ghent University Hospital

55
Rudy Van Coster
Rudy Van Coster

Ghent University Hospital

22
Sara Seneca
Sara Seneca

Ghent University Hospital

14
Willy Lissens
Willy Lissens

Vrije Universiteit Brussel

13
Kim K Creus
Kim K Creus

Ghent University Hospital

13
Jan De Bleecker
Jan De Bleecker

Center for Molecular Neurology

7