Publications by authors named "Bodo Laube"

49Publications

Thermophoretic analysis of ligand-specific conformational states of the inhibitory glycine receptor embedded in copolymer nanodiscs.

Sci Rep 2020 10 6;10(1):16569. Epub 2020 Oct 6.

Department of Biology, Neurophysiology and Neurosensory Systems, Technical University of Darmstadt, Schnittspahnstrasse 3, 64287, Darmstadt, Germany.

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http://dx.doi.org/10.1038/s41598-020-73157-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7538598PMC
October 2020

Electrical Sensing of Phosphonates by Functional Coupling of Phosphonate Binding Protein PhnD to Solid-State Nanopores.

ACS Sens 2020 01 19;5(1):234-241. Epub 2019 Dec 19.

Department of Biology, Neurophysiology and Neurosensory Systems , Technische Universität Darmstadt , Schnittspahnstrasse 3 , 64287 Darmstadt , Germany.

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http://dx.doi.org/10.1021/acssensors.9b02097DOI Listing
January 2020

Preface.

Anal Chim Acta 2019 Dec 12;1086:14-15. Epub 2019 Sep 12.

University of Louisville, USA. Electronic address:

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http://dx.doi.org/10.1016/j.aca.2019.09.027DOI Listing
December 2019

NMDA Receptor-Mediated Signaling Pathways Enhance Radiation Resistance, Survival and Migration in Glioblastoma Cells-A Potential Target for Adjuvant Radiotherapy.

Cancers (Basel) 2019 Apr 9;11(4). Epub 2019 Apr 9.

Neurophysiology and Neurosensory Systems, Technische Universität Darmstadt, Schnittspahnstrasse 3, 64287 Darmstadt, Germany.

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https://www.mdpi.com/2072-6694/11/4/503
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http://dx.doi.org/10.3390/cancers11040503DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520759PMC
April 2019

NMDA Receptor Signaling Mediates cFos Expression via Top2β-Induced DSBs in Glioblastoma Cells.

Cancers (Basel) 2019 Mar 5;11(3). Epub 2019 Mar 5.

Neurophysiology and Neurosensory Systems, Technische Universität Darmstadt, Schnittspahnstrasse 3, 64287 Darmstadt, Germany.

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http://dx.doi.org/10.3390/cancers11030306DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468437PMC
March 2019

Coupling of a viral K-channel with a glutamate-binding-domain highlights the modular design of ionotropic glutamate-receptors.

Commun Biol 2019 22;2:75. Epub 2019 Feb 22.

Department of Biology, Neurophysiology and Neurosensory Systems, Technische Universität Darmstadt, 64289, Darmstadt, Germany.

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http://dx.doi.org/10.1038/s42003-019-0320-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385376PMC
April 2020

Ligand binding domain interface: A tipping point for pharmacological agents binding with GluN1/2A subunit containing NMDA receptors.

Eur J Pharmacol 2019 Feb 13;844:216-224. Epub 2018 Dec 13.

Edward Via Virginia College of Osteopathic Medicine, Blacksburg, VA, USA; Virginia-Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg, VA, USA; School of Neuroscience, Virginia Tech, Blacksburg, VA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ejphar.2018.12.023DOI Listing
February 2019

encephalopathy: novel findings on phenotype, variant clustering, functional consequences and treatment aspects.

J Med Genet 2017 07 4;54(7):460-470. Epub 2017 Apr 4.

Institute of Human Genetics, University of Leipzig Hospitals and Clinics, Leipzig, Germany.

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http://dx.doi.org/10.1136/jmedgenet-2016-104509DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5656050PMC
July 2017

The N-terminal domain of the GluN3A subunit determines the efficacy of glycine-activated NMDA receptors.

Neuropharmacology 2016 06 9;105:133-141. Epub 2016 Jan 9.

Department of Neurochemistry, Max-Planck-Institute for Brain Research, Deutschordenstrasse 46, 60528 Frankfurt am Main, Germany; Department of Neurophysiology and Neurosensory Systems, Technische Universität Darmstadt, Schnittspahnstrasse 3, 64287 Darmstadt, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.neuropharm.2016.01.014DOI Listing
June 2016

Molecular basis for convergent evolution of glutamate recognition by pentameric ligand-gated ion channels.

Sci Rep 2015 Feb 24;5:8558. Epub 2015 Feb 24.

Neurophysiology and Neurosensory Systems, Technical University of Darmstadt, Darmstadt 64287, Germany.

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http://dx.doi.org/10.1038/srep08558DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338433PMC
February 2015

Comparative pharmacology of flatworm and roundworm glutamate-gated chloride channels: Implications for potential anthelmintics.

Int J Parasitol Drugs Drug Resist 2014 Dec 10;4(3):244-55. Epub 2014 Aug 10.

Neurophysiology and Neurosensory Systems, Technical University of Darmstadt, 64287 Darmstadt, Germany.

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http://dx.doi.org/10.1016/j.ijpddr.2014.07.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4266781PMC
December 2014

Opposing effects of the anesthetic propofol at pentameric ligand-gated ion channels mediated by a common site.

J Neurosci 2014 Feb;34(6):2155-9

Neurophysiology and Neurosensory Systems, Department of Biology, Technical University of Darmstadt, 64287 Darmstadt, Germany.

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http://dx.doi.org/10.1523/JNEUROSCI.4307-13.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6608535PMC
February 2014

Propofol modulation of α1 glycine receptors does not require a structural transition at adjacent subunits that is crucial to agonist-induced activation.

ACS Chem Neurosci 2013 Nov 17;4(11):1469-78. Epub 2013 Sep 17.

Neurophysiology and Neurosensory Systems, Technische Universität Darmstadt , Schnittspahnstrasse 3, 64287 Darmstadt, Germany.

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http://dx.doi.org/10.1021/cn400134pDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3837372PMC
November 2013

Probing the pharmacological properties of distinct subunit interfaces within heteromeric glycine receptors reveals a functional ββ agonist-binding site.

J Neurochem 2012 Jul 27;122(1):38-47. Epub 2012 Apr 27.

Department of Neurochemistry, Max-Planck-Institute for Brain Research, Frankfurt am Main, Germany.

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http://dx.doi.org/10.1111/j.1471-4159.2012.07755.xDOI Listing
July 2012

Structure-activity relationships for allosteric NMDA receptor inhibitors based on 2-naphthoic acid.

Neuropharmacology 2012 Mar 6;62(4):1730-6. Epub 2011 Dec 6.

Department of Pharmacology and Experimental Neuroscience, 985800 Nebraska Medical Center, Omaha, NE 68198-5800, USA.

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http://dx.doi.org/10.1016/j.neuropharm.2011.11.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3269548PMC
March 2012

Prolonged zymosan-induced inflammatory pain hypersensitivity in mice lacking glycine receptor alpha2.

Behav Brain Res 2012 Jan 8;226(1):106-11. Epub 2011 Sep 8.

Pharmazentrum Frankfurt/ZAFES, Institut für Klinische Pharmakologie, Klinikum der Goethe-Universität, 60590 Frankfurt am Main, Germany.

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http://linkinghub.elsevier.com/retrieve/pii/S016643281100658
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http://dx.doi.org/10.1016/j.bbr.2011.09.002DOI Listing
January 2012

Robust post-translocational N-glycosylation at the extreme C-terminus of membrane and secreted proteins in Xenopus laevis oocytes and HEK293 cells.

Glycobiology 2011 Sep 8;21(9):1147-60. Epub 2011 Feb 8.

Department of Molecular Pharmacology, RWTH Aachen University of Aachen, Wendlingweg 2, D-52074 Aachen, Germany.

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http://dx.doi.org/10.1093/glycob/cwr013DOI Listing
September 2011

Potentiation of Glycine-Gated NR1/NR3A NMDA Receptors Relieves Ca-Dependent Outward Rectification.

Front Mol Neurosci 2010 23;3. Epub 2010 Mar 23.

Department of Neurochemistry, Max-Planck Institute for Brain Research Frankfurt am Main, Germany.

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http://dx.doi.org/10.3389/fnmol.2010.00006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2854533PMC
July 2011

An intramembrane aromatic network determines pentameric assembly of Cys-loop receptors.

Nat Struct Mol Biol 2010 Jan 20;17(1):90-8. Epub 2009 Dec 20.

Molecular Pharmacology, RWTH Aachen University of Aachen, Aachen, Germany.

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http://dx.doi.org/10.1038/nsmb.1721DOI Listing
January 2010

Different binding modes of tropeines mediating inhibition and potentiation of alpha1 glycine receptors.

J Neurochem 2009 Jun 4;109(6):1725-32. Epub 2009 Apr 4.

Department of Molecular Pharmacology, Institute of Biomolecular Chemistry, Chemical Research Center, Hungarian Academy of Sciences, Budapest, Hungary.

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http://dx.doi.org/10.1111/j.1471-4159.2009.06083.xDOI Listing
June 2009

Binding-site mutations in the alpha1 subunit of the inhibitory glycine receptor convert the inhibitory metal ion Cu2+ into a positive modulator.

Neuropharmacology 2009 Jan 28;56(1):310-7. Epub 2008 Aug 28.

Abteilung Neurochemie, Max-Planck-Institut für Hirnforschung, Deutschordenstr. 46, 60528 Frankfurt am Main, Germany.

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http://dx.doi.org/10.1016/j.neuropharm.2008.08.024DOI Listing
January 2009

Supralinear potentiation of NR1/NR3A excitatory glycine receptors by Zn2+ and NR1 antagonist.

Proc Natl Acad Sci U S A 2008 Aug 18;105(34):12563-8. Epub 2008 Aug 18.

Department of Neurochemistry, Max Planck Institute for Brain Research, Deutschordenstrasse 46, 60528 Frankfurt am Main, Germany.

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http://dx.doi.org/10.1073/pnas.0805624105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2527951PMC
August 2008

Mutations within the agonist-binding site convert the homomeric alpha1 glycine receptor into a Zn2+-activated chloride channel.

Channels (Austin) 2008 Jan-Feb;2(1):13-8. Epub 2008 Mar 12.

Abteilung Neurochemie, Max-Planck-Institut für Hirnforschung, Frankfurt am Main, Germany.

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http://dx.doi.org/10.4161/chan.2.1.5931DOI Listing
November 2008

Formation of NR1/NR2 and NR1/NR3 heterodimers constitutes the initial step in N-methyl-D-aspartate receptor assembly.

J Biol Chem 2008 Jan 24;283(1):37-46. Epub 2007 Oct 24.

Max-Planck-Institut für Hirnforschung, Frankfurt 60528, Germany.

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http://dx.doi.org/10.1074/jbc.M703539200DOI Listing
January 2008

The N-terminal domains of both NR1 and NR2 subunits determine allosteric Zn2+ inhibition and glycine affinity of N-methyl-D-aspartate receptors.

Mol Pharmacol 2007 Dec 18;72(6):1535-44. Epub 2007 Sep 18.

Abteilung Neurochemie, Max-Planck-Institut für Hirnforschung, Frankfurt am Main, Germany.

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http://dx.doi.org/10.1124/mol.107.040071DOI Listing
December 2007

Hyperekplexia mutation R271L of alpha1 glycine receptors potentiates allosteric interactions of nortropeines, propofol and glycine with [3H]strychnine binding.

Neurochem Int 2008 Jan 21;52(1-2):235-40. Epub 2007 Jun 21.

Department of Molecular Pharmacology, Institute of Biomolecular Chemistry, Chemical Research Center, Hungarian Academy of Sciences, H-1525 Budapest, POB 17, Hungary.

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http://dx.doi.org/10.1016/j.neuint.2007.06.009DOI Listing
January 2008

Principal role of NR3 subunits in NR1/NR3 excitatory glycine receptor function.

Biochem Biophys Res Commun 2007 Mar 28;354(1):102-8. Epub 2006 Dec 28.

Abteilung Neurochemie, Max-Planck-Institut für Hirnforschung, Deutschordenstr. 46, 60528 Frankfurt, Germany.

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http://linkinghub.elsevier.com/retrieve/pii/S0006291X0602825
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http://dx.doi.org/10.1016/j.bbrc.2006.12.153DOI Listing
March 2007

Hyperekplexia phenotype of glycine receptor alpha1 subunit mutant mice identifies Zn(2+) as an essential endogenous modulator of glycinergic neurotransmission.

Neuron 2006 Nov;52(4):679-90

Abteilung Neurochemie, Max-Planck-Institut für Hirnforschung, Deutschordenstrasse 46, 60528 Frankfurt am Main, Germany.

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http://dx.doi.org/10.1016/j.neuron.2006.09.035DOI Listing
November 2006

Disruption of interdomain interactions in the glutamate binding pocket affects differentially agonist affinity and efficacy of N-methyl-D-aspartate receptor activation.

J Biol Chem 2007 Jan 14;282(3):1863-72. Epub 2006 Nov 14.

Max-Planck-Institute for Brain Research, Frankfurt 60528, Germany.

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http://dx.doi.org/10.1074/jbc.M608156200DOI Listing
January 2007

Glycine receptors: recent insights into their structural organization and functional diversity.

J Neurochem 2006 Jun;97(6):1600-10

Abteilung Neurochemie, Max-Planck-Institut für Hirnforschung, Frankfurt am Main, Germany.

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http://dx.doi.org/10.1111/j.1471-4159.2006.03908.xDOI Listing
June 2006

The beta subunit increases the ginkgolide B sensitivity of inhibitory glycine receptors.

Neuropharmacology 2005 Nov 24;49(6):945-51. Epub 2005 Aug 24.

Department of Neurochemistry, Max-Planck-Institute for Brain Research, Deutschordenstrasse 46, 60528 Frankfurt, Germany.

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http://dx.doi.org/10.1016/j.neuropharm.2005.07.001DOI Listing
November 2005

The beta subunit determines the ligand binding properties of synaptic glycine receptors.

Neuron 2005 Mar;45(5):727-39

Department of Neurochemistry, Max-Planck-Institute for Brain Research, Deutschordenstrasse 46, D-60528 Frankfurt am Main, Germany.

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http://dx.doi.org/10.1016/j.neuron.2005.01.028DOI Listing
March 2005

Comparative analysis of inhibitory effects of caged ligands for the NMDA receptor.

J Neurosci Methods 2005 Mar;142(1):1-9

Max-Planck-Institute for Brain Research, Deutschordenstr. 46, D-60528 Frankfurt, Germany.

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https://linkinghub.elsevier.com/retrieve/pii/S01650270040025
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http://dx.doi.org/10.1016/j.jneumeth.2004.07.006DOI Listing
March 2005

Molecular determinants of ligand discrimination in the glutamate-binding pocket of the NMDA receptor.

Neuropharmacology 2004 Dec;47(7):994-1007

Department of Neurochemistry, Max-Planck-Institute for Brain Research, Deutschordenstrasse 46, 60528 Frankfurt, Germany.

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http://dx.doi.org/10.1016/j.neuropharm.2004.07.041DOI Listing
December 2004

Deletion of the mouse glycine transporter 2 results in a hyperekplexia phenotype and postnatal lethality.

Neuron 2003 Nov;40(4):797-806

Department of Neurochemistry, Max-Planck-Institute for Brain Research, Deutschordenstrasse 46, 60528 Frankfurt, Germany.

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http://dx.doi.org/10.1016/s0896-6273(03)00673-1DOI Listing
November 2003

ATP inhibits NMDA receptors after heterologous expression and in cultured hippocampal neurons and attenuates NMDA-mediated neurotoxicity.

J Neurosci 2003 Jun;23(12):4996-5003

Biozentrum der J. W. Goethe-Universität, Arbeitskreis Neurochemie, Zoologisches Institut, D-60439 Frankfurt am Main, Germany.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6741184PMC
June 2003

Structural model of the N-methyl-D-aspartate receptor glycine site probed by site-directed chemical coupling.

J Biol Chem 2003 Jun 15;278(26):24011-7. Epub 2003 Apr 15.

Laboratoire de Chimie Bioorganique, CNRS UMR 7514, Faculté de Pharmacie, Université Louis Pasteur de Strasbourg, F-67401 Illkirch, France.

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http://dx.doi.org/10.1074/jbc.M300219200DOI Listing
June 2003

A basic cluster determines topology of the cytoplasmic M3-M4 loop of the glycine receptor alpha1 subunit.

J Biol Chem 2003 May 28;278(19):16782-90. Epub 2003 Feb 28.

Department of Molecular Pharmacology, Medical School of the Technical University of Aachen, Wendlingweg 2, D-52074 Aachen, Germany.

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http://dx.doi.org/10.1074/jbc.M213077200DOI Listing
May 2003

Modulation of glycine receptor function: a novel approach for therapeutic intervention at inhibitory synapses?

Trends Pharmacol Sci 2002 Nov;23(11):519-27

Dept. of Neurochemistry, Max-Planck-Institute for Brain Research, Deutschordenstrasse 46, 60528, Frankfurt, Germany.

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http://dx.doi.org/10.1016/s0165-6147(02)02138-7DOI Listing
November 2002

Potentiation of inhibitory glycinergic neurotransmission by Zn2+: a synergistic interplay between presynaptic P2X2 and postsynaptic glycine receptors.

Authors:
Bodo Laube

Eur J Neurosci 2002 Sep;16(6):1025-36

Department of Neurochemistry, Max-Planck-Institute for Brain Research, Deutschordenstrasse 46, 60528 Frankfurt, Germany.

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http://dx.doi.org/10.1046/j.1460-9568.2002.02170.xDOI Listing
September 2002

Hyperekplexia mutation of glycine receptors: decreased gating efficacy with altered binding thermodynamics.

Biochem Pharmacol 2002 Jul;64(2):285-8

Department of Molecular Pharmacology, Chemical Research Centre, Hungarian Academy of Sciences, P.O. Box 17, H-1525 Budapest, Hungary.

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http://dx.doi.org/10.1016/s0006-2952(02)01111-5DOI Listing
July 2002