Publications by authors named "Bob van de Water"

100Publications

Mining a human transcriptome database for chemical modulators of NRF2.

PLoS One 2020 28;15(9):e0239367. Epub 2020 Sep 28.

Center for Computational Toxicology and Exposure, US-EPA, Research Triangle Park, NC, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0239367PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7521735PMC
September 2020

Correction to: Multiparametric assessment of mitochondrial respiratory inhibition in HepG2 and RPTEC/TERT1 cells using a panel of mitochondrial targeting agrochemicals.

Arch Toxicol 2020 08;94(8):2731-2732

Division of Molecular and Computational Toxicology, Department of Chemistry and Pharmaceutical Sciences, AIMMS, Vrije Universiteit Amsterdam, De Boelelaan, 1108, 1081 HZ, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1007/s00204-020-02849-5DOI Listing
August 2020

Multiparametric assessment of mitochondrial respiratory inhibition in HepG2 and RPTEC/TERT1 cells using a panel of mitochondrial targeting agrochemicals.

Arch Toxicol 2020 08 18;94(8):2707-2729. Epub 2020 Jul 18.

Division of Molecular and Computational Toxicology, Department of Chemistry and Pharmaceutical Sciences, AIMMS, Vrije Universiteit Amsterdam, De Boelelaan, 1108, 1081 HZ, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1007/s00204-020-02792-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7395062PMC
August 2020

Quantitative phosphoproteomics to unravel the cellular response to chemical stressors with different modes of action.

Arch Toxicol 2020 05 18;94(5):1655-1671. Epub 2020 Mar 18.

Department of Human Genetics, Leiden University Medical Center, P.O. Box 9600, 2300 RC, Leiden, The Netherlands.

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http://dx.doi.org/10.1007/s00204-020-02712-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7261734PMC
May 2020

ATF6 Is a Critical Determinant of CHOP Dynamics during the Unfolded Protein Response.

iScience 2020 Feb 23;23(2):100860. Epub 2020 Jan 23.

Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research, Leiden University, Einsteinweg 55, 2333 CC Leiden, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.isci.2020.100860DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7005498PMC
February 2020

The hepatotoxic fluoroquinolone trovafloxacin disturbs TNF- and LPS-induced p65 nuclear translocation in vivo and in vitro.

Toxicol Appl Pharmacol 2020 03 6;391:114915. Epub 2020 Feb 6.

Immunotoxicology, Institute for Risk Assessment Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.taap.2020.114915DOI Listing
March 2020

Statement on advancing the assessment of chemical mixtures and their risks for human health and the environment.

Environ Int 2020 01 6;134:105267. Epub 2019 Nov 6.

Stockholm University, ACES, SE-106 91 Stockholm, Sweden; Örebro University, Department of Science and Technology, SE-701 82 Örebro, Sweden; State Key Laboratory of Pollution Control and Resource Reuse, College of Environmental Science and Engineering, Tongji University, Shanghai 200092, China.

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http://dx.doi.org/10.1016/j.envint.2019.105267DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6979318PMC
January 2020

Splicing regulatory factors in breast cancer hallmarks and disease progression.

Oncotarget 2019 Oct 15;10(57):6021-6037. Epub 2019 Oct 15.

Division of Drug Discovery and Safety, LACDR, Leiden University, Leiden, The Netherlands.

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http://dx.doi.org/10.18632/oncotarget.27215DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6800274PMC
October 2019

FRET biosensor-based kinase inhibitor screen for ERK and AKT activity reveals differential kinase dependencies for proliferation in TNBC cells.

Biochem Pharmacol 2019 11 16;169:113640. Epub 2019 Sep 16.

Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research, Leiden University, 2300 RA Leiden, the Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2019.113640DOI Listing
November 2019

An increased cell cycle gene network determines MEK and Akt inhibitor double resistance in triple-negative breast cancer.

Sci Rep 2019 09 16;9(1):13308. Epub 2019 Sep 16.

Division of Drug Discovery and Safety, Leiden Academic Center for Drug Research, Leiden University, PO box 9502, 2300, RA, Leiden, The Netherlands.

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http://dx.doi.org/10.1038/s41598-019-49809-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6746778PMC
September 2019

Multi-targeted kinase inhibition alleviates mTOR inhibitor resistance in triple-negative breast cancer.

Breast Cancer Res Treat 2019 Nov 6;178(2):263-274. Epub 2019 Aug 6.

Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research, Leiden University, 2300 RA, Leiden, The Netherlands.

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http://dx.doi.org/10.1007/s10549-019-05380-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6797661PMC
November 2019

A kinase inhibitor screen identifies a dual cdc7/CDK9 inhibitor to sensitise triple-negative breast cancer to EGFR-targeted therapy.

Breast Cancer Res 2019 07 1;21(1):77. Epub 2019 Jul 1.

Department of Drug Discovery and Safety, Leiden Academic Centre for Drug Research, Leiden University, 2300 RA, Leiden, The Netherlands.

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http://dx.doi.org/10.1186/s13058-019-1161-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6604188PMC
July 2019

Corrigendum: Investigation of Nrf2, AhR and ATF4 Activation in Toxicogenomic Databases.

Front Genet 2019 4;10:517. Epub 2019 Jun 4.

Division of Molecular and Computational Toxicology, Amsterdam Institute for Molecules, Medicines and Systems, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.

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http://dx.doi.org/10.3389/fgene.2019.00517DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6558953PMC
June 2019

Development of a neurotoxicity assay that is tuned to detect mitochondrial toxicants.

Arch Toxicol 2019 06 12;93(6):1585-1608. Epub 2019 Jun 12.

Chair for In Vitro Toxicology and Biomedicine, Department of Inaugurated by the Doerenkamp-Zbinden Foundation, University of Konstanz, Universitaetsstr. 10, 78457, Constance, Germany.

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http://dx.doi.org/10.1007/s00204-019-02473-yDOI Listing
June 2019

System Microscopy of Stress Response Pathways in Cholestasis Research.

Methods Mol Biol 2019 ;1981:187-202

Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research (LACDR), Leiden University, Leiden, The Netherlands.

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http://dx.doi.org/10.1007/978-1-4939-9420-5_13DOI Listing
August 2019

Co-regulated gene expression of splicing factors as drivers of cancer progression.

Sci Rep 2019 04 2;9(1):5484. Epub 2019 Apr 2.

Division of Drug Discovery and Safety, LACDR, Leiden University, Leiden, The Netherlands.

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http://dx.doi.org/10.1038/s41598-019-40759-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445126PMC
April 2019

A systematic analysis of Nrf2 pathway activation dynamics during repeated xenobiotic exposure.

Arch Toxicol 2019 02 20;93(2):435-451. Epub 2018 Nov 20.

Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research, Leiden University, Einsteinweg 55, 2333 CC, Leiden, The Netherlands.

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http://dx.doi.org/10.1007/s00204-018-2353-2DOI Listing
February 2019

Investigation of Nrf2, AhR and ATF4 Activation in Toxicogenomic Databases.

Front Genet 2018 2;9:429. Epub 2018 Oct 2.

Division of Molecular and Computational Toxicology, Amsterdam Institute for Molecules, Medicines and Systems, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.

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https://www.frontiersin.org/article/10.3389/fgene.2018.00429
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http://dx.doi.org/10.3389/fgene.2018.00429DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6176024PMC
October 2018

Comparison of base-line and chemical-induced transcriptomic responses in HepaRG and RPTEC/TERT1 cells using TempO-Seq.

Arch Toxicol 2018 08 14;92(8):2517-2531. Epub 2018 Jul 14.

Division of Molecular and Computational Toxicology, Amsterdam Institute for Molecules, Medicines and Systems, Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ, Amsterdam, The Netherlands.

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http://link.springer.com/10.1007/s00204-018-2256-2
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http://dx.doi.org/10.1007/s00204-018-2256-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6063331PMC
August 2018

Glutathione -Transferase P1 Protects Against Amodiaquine Quinoneimines-Induced Cytotoxicity but Does Not Prevent Activation of Endoplasmic Reticulum Stress in HepG2 Cells.

Front Pharmacol 2018 18;9:388. Epub 2018 Apr 18.

Division of Molecular Toxicology, Department of Chemistry and Pharmaceutical Sciences, Amsterdam Institute for Molecules, Medicines and Systems, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.

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http://dx.doi.org/10.3389/fphar.2018.00388DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5915463PMC
April 2018

Dynamic imaging of adaptive stress response pathway activation for prediction of drug induced liver injury.

Arch Toxicol 2018 05 3;92(5):1797-1814. Epub 2018 Mar 3.

Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research, Leiden University, Einsteinweg 55, 2333 CC, Leiden, The Netherlands.

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http://dx.doi.org/10.1007/s00204-018-2178-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5962642PMC
May 2018

Insulin-like growth factor 1 receptor activation promotes mammary gland tumor development by increasing glycolysis and promoting biomass production.

Breast Cancer Res 2017 02 7;19(1):14. Epub 2017 Feb 7.

Division of Toxicology, Leiden Academic Centre for Drug Research, Leiden University, Einsteinweg 55, 2333, CC, Leiden, The Netherlands.

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http://dx.doi.org/10.1186/s13058-017-0802-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5297135PMC
February 2017

Comprehensive Landscape of Nrf2 and p53 Pathway Activation Dynamics by Oxidative Stress and DNA Damage.

Chem Res Toxicol 2017 04 16;30(4):923-933. Epub 2016 Dec 16.

Division of Toxicology, Leiden Academic Centre for Drug Research, Leiden University , Einsteinweg 55, 2333 CC Leiden, The Netherlands.

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http://dx.doi.org/10.1021/acs.chemrestox.6b00322DOI Listing
April 2017

Unraveling cellular pathways contributing to drug-induced liver injury by dynamical modeling.

Expert Opin Drug Metab Toxicol 2017 Jan 23;13(1):5-17. Epub 2016 Sep 23.

a Division of Toxicology, Leiden Academic Centre for Drug Research , Leiden University , Leiden , The Netherlands.

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http://dx.doi.org/10.1080/17425255.2017.1234607DOI Listing
January 2017

Development of a 3D Tissue Culture-Based High-Content Screening Platform That Uses Phenotypic Profiling to Discriminate Selective Inhibitors of Receptor Tyrosine Kinases.

J Biomol Screen 2016 Oct 7;21(9):912-22. Epub 2016 Jul 7.

Division of Toxicology, Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands OcellO B.V., Leiden, The Netherlands

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5030728PMC
http://dx.doi.org/10.1177/1087057116657269DOI Listing
October 2016

High-content imaging-based BAC-GFP toxicity pathway reporters to assess chemical adversity liabilities.

Arch Toxicol 2017 Mar 29;91(3):1367-1383. Epub 2016 Jun 29.

Division of Toxicology, Leiden Academic Centre for Drug Research, Leiden University, Einsteinweg 55, 2333 CC, Leiden, The Netherlands.

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http://link.springer.com/10.1007/s00204-016-1781-0
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http://dx.doi.org/10.1007/s00204-016-1781-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5316409PMC
March 2017

Imprinted survival genes preclude loss of heterozygosity of chromosome 7 in cancer cells.

J Pathol 2016 09;240(1):72-83

Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1002/path.4756DOI Listing
September 2016

Highlight report: Launch of a large integrated European in vitro toxicology project: EU-ToxRisk.

Arch Toxicol 2016 May 26;90(5):1021-4. Epub 2016 Mar 26.

Division of Toxicology, Leiden Academic Center for Drug Research, Leiden University, Leiden, The Netherlands.

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http://dx.doi.org/10.1007/s00204-016-1698-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4830874PMC
May 2016

Tumor-induced remote ECM network orientation steers angiogenesis.

Sci Rep 2016 Mar 2;6:22580. Epub 2016 Mar 2.

Division of Toxicology, Leiden Academic Center for Drug Research, Leiden University, Leiden, the Netherlands.

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http://dx.doi.org/10.1038/srep22580DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4773852PMC
March 2016

Pharmacological inhibition of Bcl-xL sensitizes osteosarcoma to doxorubicin.

Oncotarget 2015 Nov;6(34):36113-25

Division of Toxicology, Leiden/Academic Center for Drug Research, Leiden University, 2300 RA Leiden, The Netherlands.

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http://dx.doi.org/10.18632/oncotarget.5333DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4742165PMC
November 2015

The adhesion G protein-coupled receptor G2 (ADGRG2/GPR64) constitutively activates SRE and NFκB and is involved in cell adhesion and migration.

Cell Signal 2015 Dec 29;27(12):2579-88. Epub 2015 Aug 29.

Novo Nordisk Foundation Center for Basic Metabolic Research, Section for Metabolic Receptology and Enteroendocrinology, Faculty of Health Sciences, University of Copenhagen, Denmark.

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http://dx.doi.org/10.1016/j.cellsig.2015.08.015DOI Listing
December 2015

Alternative signaling network activation through different insulin receptor family members caused by pro-mitogenic antidiabetic insulin analogues in human mammary epithelial cells.

Breast Cancer Res 2015 Jul 19;17:97. Epub 2015 Jul 19.

Division of Toxicology, Leiden Academic Centre for Drug Research, Leiden University, Einsteinweg 55, Leiden, 2333 CC, The Netherlands.

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http://dx.doi.org/10.1186/s13058-015-0600-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4506606PMC
July 2015

Activation of the Nrf2 response by intrinsic hepatotoxic drugs correlates with suppression of NF-κB activation and sensitizes toward TNFα-induced cytotoxicity.

Arch Toxicol 2016 May 31;90(5):1163-79. Epub 2015 May 31.

Division of Toxicology, Leiden Academic Center for Drug Research, Leiden University, Einsteinweg 55, 2333 CC, Leiden, The Netherlands.

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http://dx.doi.org/10.1007/s00204-015-1536-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4830895PMC
May 2016

Aven-mediated checkpoint kinase control regulates proliferation and resistance to chemotherapy in conventional osteosarcoma.

J Pathol 2015 Jul 30;236(3):348-59. Epub 2015 Mar 30.

Division of Toxicology, Leiden Academic Centre for Drug Research, Leiden University, The Netherlands.

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http://dx.doi.org/10.1002/path.4528DOI Listing
July 2015

Stem cell-derived systems in toxicology assessment.

Stem Cells Dev 2015 Jun 31;24(11):1284-96. Epub 2015 Mar 31.

19Division of Toxicology, Leiden Academic Centre for Drug Research, Leiden University, Leiden, the Netherlands.

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http://dx.doi.org/10.1089/scd.2014.0540DOI Listing
June 2015

Vaccine-induced tumor necrosis factor-producing T cells synergize with cisplatin to promote tumor cell death.

Clin Cancer Res 2015 Feb 12;21(4):781-94. Epub 2014 Dec 12.

Department of Immunohematology and Blood Transfusion, Leiden University Medical Center (LUMC), Leiden, the Netherlands. ISA Pharmaceuticals, Leiden, the Netherlands.

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http://dx.doi.org/10.1158/1078-0432.CCR-14-2142DOI Listing
February 2015

A transcriptomics-based hepatotoxicity comparison between the zebrafish embryo and established human and rodent in vitro and in vivo models using cyclosporine A, amiodarone and acetaminophen.

Toxicol Lett 2015 Jan 24;232(2):403-12. Epub 2014 Nov 24.

Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), P.O. Box 1, 3720 BA Bilthoven, The Netherlands.

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https://linkinghub.elsevier.com/retrieve/pii/S03784274140147
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http://dx.doi.org/10.1016/j.toxlet.2014.11.020DOI Listing
January 2015

A novel toxicogenomics-based approach to categorize (non-)genotoxic carcinogens.

Arch Toxicol 2015 Dec 2;89(12):2413-27. Epub 2014 Oct 2.

Center for Health Protection, National Institute for Public Health and the Environment, P.O. Box 1, 3720 BA, Bilthoven, The Netherlands.

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http://dx.doi.org/10.1007/s00204-014-1368-6DOI Listing
December 2015

A computational study of the Warburg effect identifies metabolic targets inhibiting cancer migration.

Mol Syst Biol 2014 Aug 1;10:744. Epub 2014 Aug 1.

The Blavatnik School of Computer Science, Tel-Aviv University, Tel-Aviv, Israel The Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4299514PMC
http://dx.doi.org/10.15252/msb.20134993DOI Listing
August 2014

Gene expression markers in the zebrafish embryo reflect a hepatotoxic response in animal models and humans.

Toxicol Lett 2014 Oct 24;230(1):48-56. Epub 2014 Jul 24.

Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), P.O. Box 1, 3720 BA Bilthoven, The Netherlands. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03784274140109
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http://dx.doi.org/10.1016/j.toxlet.2014.06.844DOI Listing
October 2014

Epidermal growth factor receptor signalling in human breast cancer cells operates parallel to estrogen receptor α signalling and results in tamoxifen insensitive proliferation.

BMC Cancer 2014 Apr 23;14:283. Epub 2014 Apr 23.

Leiden Academic Centre for Drug Research (LACDR), Department of Toxicology, Leiden University, Einsteinweg 55, 2333 CC Leiden The Netherlands.

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http://dx.doi.org/10.1186/1471-2407-14-283DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4021213PMC
April 2014

Drug-induced endoplasmic reticulum and oxidative stress responses independently sensitize toward TNFα-mediated hepatotoxicity.

Toxicol Sci 2014 Jul 20;140(1):144-59. Epub 2014 Apr 20.

Division of Toxicology, Leiden Academic Centre for Drug Research, Leiden University, 2333 CC Leiden The Netherlands

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http://dx.doi.org/10.1093/toxsci/kfu072DOI Listing
July 2014

A 3D in vitro model of differentiated HepG2 cell spheroids with improved liver-like properties for repeated dose high-throughput toxicity studies.

Arch Toxicol 2014 May 6;88(5):1083-95. Epub 2014 Mar 6.

Division of Toxicology, Leiden Academic Centre for Drug Research, Leiden University, Einsteinweg 55, P.O. Box 9502, 2300 RA, Leiden, The Netherlands.

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http://dx.doi.org/10.1007/s00204-014-1215-9DOI Listing
May 2014

Epac-Rap signaling reduces oxidative stress in the tubular epithelium.

J Am Soc Nephrol 2014 Jul 7;25(7):1474-85. Epub 2014 Feb 7.

Division of Toxicology, Leiden Academic Centre for Drug Research, Leiden, The Netherlands; OcellO BV, Leiden, The Netherlands.

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http://dx.doi.org/10.1681/ASN.2013070679DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4073429PMC
July 2014

Quantitative high content imaging of cellular adaptive stress response pathways in toxicity for chemical safety assessment.

Chem Res Toxicol 2014 Mar 5;27(3):338-55. Epub 2014 Feb 5.

Division of Toxicology, Leiden Academic Centre for Drug Research (LACDR), Leiden University , The Netherlands.

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http://pubs.acs.org/doi/10.1021/tx4004038
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http://dx.doi.org/10.1021/tx4004038DOI Listing
March 2014

Identification of cisplatin-regulated metabolic pathways in pluripotent stem cells.

PLoS One 2013 16;8(10):e76476. Epub 2013 Oct 16.

Department of Toxicology, LACDR, Leiden University, Leiden, The Netherlands ; Netherlands Toxicogenomics Center, Maastricht, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0076476PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3797786PMC
August 2014

A screen for apoptotic synergism between clinical relevant nephrotoxicant and the cytokine TNF-α.

Toxicol In Vitro 2013 Dec 13;27(8):2264-72. Epub 2013 Sep 13.

Division of Toxicology, Leiden Academic Center for Drug Research, Leiden University, The Netherlands.

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http://dx.doi.org/10.1016/j.tiv.2013.09.004DOI Listing
December 2013

Unraveling DNA damage response-signaling networks through systems approaches.

Arch Toxicol 2013 Sep 13;87(9):1635-48. Epub 2013 Aug 13.

Division of Toxicology, Leiden Academic Center for Drug Research, Leiden University, PO Box 9502, 2300 RA, Leiden, The Netherlands.

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http://link.springer.com/10.1007/s00204-013-1106-5
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http://dx.doi.org/10.1007/s00204-013-1106-5DOI Listing
September 2013

The nuclear factor κB family member RelB facilitates apoptosis of renal epithelial cells caused by cisplatin/tumor necrosis factor α synergy by suppressing an epithelial to mesenchymal transition-like phenotypic switch.

Mol Pharmacol 2013 Jul 26;84(1):128-38. Epub 2013 Apr 26.

Division of Toxicology, Leiden Academic Centre for Drug Research, Leiden University, Gorlaeus Laboratory, Einsteinweg 55, 2333 CC Leiden, The Netherlands.

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http://dx.doi.org/10.1124/mol.112.084053DOI Listing
July 2013

Systems biology approach identifies the kinase Csnk1a1 as a regulator of the DNA damage response in embryonic stem cells.

Sci Signal 2013 Jan 22;6(259):ra5. Epub 2013 Jan 22.

Division of Toxicology, Leiden/Amsterdam Center for Drug Research, Leiden University, P. O. Box 9502, 2300 RA Leiden, The Netherlands.

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http://dx.doi.org/10.1126/scisignal.2003208DOI Listing
January 2013

Cellular-signaling pathways unveil the carcinogenic potential of chemicals.

J Appl Toxicol 2013 Jun 22;33(6):399-409. Epub 2013 Jan 22.

Department of Toxicogenetics, Leiden University Medical Center, PO Box 9600, 2300, RC, Leiden, The Netherlands.

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http://dx.doi.org/10.1002/jat.2845DOI Listing
June 2013

Automated analysis of NF-κB nuclear translocation kinetics in high-throughput screening.

PLoS One 2012 27;7(12):e52337. Epub 2012 Dec 27.

Division of Toxicology, Leiden/Amsterdam Center for Drug Research, Leiden University, Leiden, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0052337PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3531459PMC
July 2013

TNF-α-mediated NF-κB survival signaling impairment by cisplatin enhances JNK activation allowing synergistic apoptosis of renal proximal tubular cells.

Biochem Pharmacol 2013 Jan 24;85(2):274-86. Epub 2012 Oct 24.

Division of Toxicology, Leiden/Amsterdam Center for Drug Research, Leiden University, The Netherlands.

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http://linkinghub.elsevier.com/retrieve/pii/S000629521200688
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http://dx.doi.org/10.1016/j.bcp.2012.10.012DOI Listing
January 2013

AMAP, the alleged non-toxic isomer of acetaminophen, is toxic in rat and human liver.

Arch Toxicol 2013 Jan 23;87(1):155-65. Epub 2012 Aug 23.

Division of Pharmacokinetics, Toxicology and Targeting, Department of Pharmacy, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands.

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http://dx.doi.org/10.1007/s00204-012-0924-1DOI Listing
January 2013

The residence time of focal adhesion kinase (FAK) and paxillin at focal adhesions in renal epithelial cells is determined by adhesion size, strength and life cycle status.

J Cell Sci 2012 Oct 5;125(Pt 19):4498-506. Epub 2012 Jul 5.

Division of Toxicology, Leiden/Amsterdam Center for Drug Research, Leiden University, Leiden, Gorlaeus Laboratoria, PO Box 9502, 2300 RA Leiden, The Netherlands.

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http://dx.doi.org/10.1242/jcs.104273DOI Listing
October 2012

Dissecting modes of action of non-genotoxic carcinogens in primary mouse hepatocytes.

Arch Toxicol 2012 Nov 19;86(11):1717-27. Epub 2012 Jun 19.

Laboratory for Health Protection Research, National Institute for Public Health and the Environment, Bilthoven, The Netherlands.

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http://link.springer.com/10.1007/s00204-012-0883-6
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http://dx.doi.org/10.1007/s00204-012-0883-6DOI Listing
November 2012

Examination of the cytotoxic and embryotoxic potential and underlying mechanisms of next-generation synthetic trioxolane and tetraoxane antimalarials.

Mol Med 2012 Sep 25;18:1045-55. Epub 2012 Sep 25.

MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, The University of Liverpool, Sherrington Buildings, Ashton Street, Liverpool, United Kingdom.

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http://dx.doi.org/10.2119/molmed.2012.00154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3474437PMC
September 2012

Automated whole animal bio-imaging assay for human cancer dissemination.

PLoS One 2012 8;7(2):e31281. Epub 2012 Feb 8.

Division of Toxicology, Leiden/Amsterdam Center for Drug Research, Leiden University, Leiden, the Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0031281PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3275564PMC
July 2012

Automated microinjection of cell-polymer suspensions in 3D ECM scaffolds for high-throughput quantitative cancer invasion screens.

Biomaterials 2012 Jan 20;33(1):181-8. Epub 2011 Oct 20.

Division of Toxicology, Leiden Amsterdam Center for Drug Research, Leiden University, Einsteinweg 55, 2333 CC Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.biomaterials.2011.09.049DOI Listing
January 2012