Publications by authors named "Bo Zhu"

895 Publications

Face-Computer Interface (FCI): Intent Recognition Based on Facial Electromyography (fEMG) and Online Human-Computer Interface With Audiovisual Feedback.

Front Neurorobot 2021 16;15:692562. Epub 2021 Jul 16.

Rehabilitation Center, Shengjing Hospital of China Medical University, Shenyang, China.

Patients who have lost limb control ability, such as upper limb amputation and high paraplegia, are usually unable to take care of themselves. Establishing a natural, stable, and comfortable human-computer interface (HCI) for controlling rehabilitation assistance robots and other controllable equipments will solve a lot of their troubles. In this study, a complete limbs-free face-computer interface (FCI) framework based on facial electromyography (fEMG) including offline analysis and online control of mechanical equipments was proposed. Six facial movements related to eyebrows, eyes, and mouth were used in this FCI. In the offline stage, 12 models, eight types of features, and three different feature combination methods for model inputing were studied and compared in detail. In the online stage, four well-designed sessions were introduced to control a robotic arm to complete drinking water task in three ways (by touch screen, by fEMG with and without audio feedback) for verification and performance comparison of proposed FCI framework. Three features and one model with an average offline recognition accuracy of 95.3%, a maximum of 98.8%, and a minimum of 91.4% were selected for use in online scenarios. In contrast, the way with audio feedback performed better than that without audio feedback. All subjects completed the drinking task in a few minutes with FCI. The average and smallest time difference between touch screen and fEMG under audio feedback were only 1.24 and 0.37 min, respectively.
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http://dx.doi.org/10.3389/fnbot.2021.692562DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8322851PMC
July 2021

Integration of selection signatures and multi-trait GWAS reveals polygenic genetic architecture of carcass traits in beef cattle.

Genomics 2021 Jul 25;113(5):3325-3336. Epub 2021 Jul 25.

Key Laboratory of Animal Genetics Breeding and Reproduction, Ministry of Agriculture and Rural Affairs, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100193, China. Electronic address:

Carcass merits are widely considered as economically important traits affecting beef production in the beef cattle industry. However, the genetic basis of carcass traits remains to be well understood. Here, we applied multiple methods, including the Composite of Likelihood Ratio (CLR) and Genome-wide Association Study (GWAS), to explore the selection signatures and candidate variants affecting carcass traits. We identified 11,600 selected regions overlapping with 2214 candidate genes, and most of those were enriched in binding and gene regulation. Notably, we identified 66 and 110 potential variants significantly associated with carcass traits using single-trait and multi-traits analyses, respectively. By integrating selection signatures with single and multi-traits associations, we identified 12 and 27 putative genes, respectively. Several highly conserved missense variants were identified in OR5M13D, NCAPG, and TEX2. Our study supported polygenic genetic architecture of carcass traits and provided novel insights into the genetic basis of complex traits in beef cattle.
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http://dx.doi.org/10.1016/j.ygeno.2021.07.025DOI Listing
July 2021

Soil type affects not only magnitude but also thermal sensitivity of NO emissions in subtropical mountain area.

Sci Total Environ 2021 Jul 18;797:149127. Epub 2021 Jul 18.

Institute of Bio- and Geosciences - Agrosphere (IBG-3), Forschungszentrum Jülich GmbH, 52425 Jülich, Germany.

It is a concern whether the effect of soil type on NO emissions has to be considered for regional mitigation strategies and emission estimates in mountainous areas with inherent spatial heterogeneities of soil type. To date, there were few field experiments which investigated soil type effects on NO emissions. Thus a 2-year field study was conducted to measure NO emissions and soil environmental variables from three different soils that were formed from similar parental rock under the same climate. Seasonal NO fluxes ranged from 0.18 to 0.40 kg N ha for wheat seasons and 0.40 to 1.50 kg N ha for maize seasons across different experimental soils. The intra- and inter-annual variations in NO emissions were mainly triggered by temporal dynamics of soil temperature and moisture conditions. On average, seasonal NO fluxes for acidic soils were significantly lower than for neutral and alkaline soils in cold-dry wheat seasons while significantly greater than for neutral and alkaline soils in warm-wet maize seasons. These determined differences of NO emissions were mainly caused by differences of initial soil properties across different soils. Moreover, seasonal NO fluxes were positively correlated with soil pH in wheat seasons, but negatively correlated in maize seasons. The temperature sensitivity coefficient (Q) of soil NO emissions for acidic soil (4.06) were significantly greater than those for neutral (1.82) and alkaline (1.15) soils. Overall, NO emissions for acidic soils were not only higher than those for neutral and alkaline soils but also more sensitive to changing temperature. The present study highlights that soil type is needed to be carefully considered for regional estimate and proposing mitigation strategy of NO emissions especially in subtropical mountain regions with inherent great heterogeneity of soil type.
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http://dx.doi.org/10.1016/j.scitotenv.2021.149127DOI Listing
July 2021

Hierarchical Photothermal Fabrics with Low Evaporation Enthalpy as Heliotropic Evaporators for Efficient, Continuous, Salt-Free Desalination.

ACS Nano 2021 Jul 26. Epub 2021 Jul 26.

State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Shanghai Belt and Road Joint Laboratory of Advanced Fiber and Low-Dimension Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, China.

Solar-driven seawater evaporation is usually achieved on floating evaporators, but the performances are substantially limited by high evaporation enthalpy, solid salt crystallization, and reduced evaporation due to inclined sunlight. To solve these problems, we fabricated hierarchical [email protected] sulfide ([email protected]) fabrics and proposed a prototype of heliotropic evaporator. Hierarchical [email protected] fabrics show significantly decreased water-evaporation enthalpy (1956.32 kJ kg, 40 °C), compared with that of pure water (2406.17 kJ kg, 40 °C), because of the disorganization of the hydrogen bonds at the CuS interfaces. Based on this fabric, a heliotropic evaporation model was developed, where seawater slowly flows from high to low in the fabric. Under solar irradiation (1.0 kW m), this model exhibits a high-rate evaporation (∼2.27 kg m h) and saturated brine production without solid salt crystallization. In particular, under inclined sunlight (angle range: from -90° to +90°), the heliotropic model retains an almost unchanged solar evaporation rate, whereas the floating model shows severe evaporation reduction (83.9%). Therefore, our study provides a strategy for reducing the evaporation enthalpy, maximally utilizing solar energy and continuous salt-free desalination.
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http://dx.doi.org/10.1021/acsnano.1c01900DOI Listing
July 2021

Postoperative Bone Marrow Lesions (BMLs) Are Associated with Pain Severity in Patients Undergoing Open Wedge High Tibial Osteotomy (OWHTO).

Biomed Res Int 2021 7;2021:9938037. Epub 2021 Jul 7.

Department of Sports Medicine and Arthroscopy, Tianjin Hospital of Tianjin University, Tianjin, China.

The purpose of the study was to investigate the relationship between postoperative bone marrow lesions (BMLs) and pain severity in patients undergoing open wedge high tibial osteotomy (OWHTO). We reviewed the patients undergoing OWHTO between April 2018 and April 2020. The demographic and clinical data of patients were collected. Clinically, VAS and Knee injury and Osteoarthritis Outcome Score (KOOS) were used to assess pain level and functional outcomes of patients. The MRI Osteoarthritis Knee Score (MOAKS) was used to assess the total BMLs size in medial tibiofemoral (MTF), lateral tibiofemoral (LTF), and patellofemoral (PF) joints. 98 patients were enrolled in the study, including 57 male and 41 female patients. The VAS scores improved significantly from 6.1 ± 0.8 to 1.5 ± 0.9 ( < 0.001), and all subscales of KOOS improved significantly after surgery ( < 0.001). There were no significant differences between the pre- and postoperative total BML size of PF and LTF joints ( > 0.05). We observed significant improvements in the total BML size of MTF joint ( < 0.001). The VAS scores and KOOS pain scores improved better in patients without postoperative MTF joint BMLs ( < 0.001). Postoperative MTF joint BMLs were correlated with postoperative VAS ( < 0.001) and KOOS pain ( < 0.001). Our study demonstrates that MTF joint BMLs improved significantly after OWTHO. We confirmed that the presence of postoperative MTF joint BMLs are strongly associated with pain severity. The greater the improvement in postoperative MTF joint BMLs, the less pain. Our findings provide valuable understandings of OWHTO in the treatment of knee osteoarthritis (KOA) and potential future directions for KOA treatment approaches.
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http://dx.doi.org/10.1155/2021/9938037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8282374PMC
July 2021

A key antisense sRNA modulates the oxidative stress response and virulence in Xanthomonas oryzae pv. oryzicola.

PLoS Pathog 2021 Jul 23;17(7):e1009762. Epub 2021 Jul 23.

Shanghai Yangtze River Delta Eco-Environmental Change and Management Observation and Research Station, Ministry of Science and Technology, Ministry of Education, Shanghai Urban Forest Ecosystem Research Station, National Forestry and Grassland Administration, Shanghai Cooperative Innovation Center for Modern Seed Industry, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, China.

Pathogens integrate multiple environmental signals to navigate the host and control the expression of virulence genes. In this process, small regulatory noncoding RNAs (sRNAs) may function in gene expression as post-transcriptional regulators. In this study, the sRNA Xonc3711 functioned in the response of the rice pathogen, Xanthomonas oryzae pv. oryzicola (Xoc), to oxidative stress. Xonc3711 repressed production of the DNA-binding protein Xoc_3982 by binding to the xoc_3982 mRNA within the coding region. Mutational analysis showed that regulation required an antisense interaction between Xonc3711 and xoc_3982 mRNA, and RNase E was needed for degradation of the xoc_3982 transcript. Deletion of Xonc3711 resulted in a lower tolerance to oxidative stress due to the repression of flagella-associated genes and reduced biofilm formation. Furthermore, ChIP-seq and electrophoretic mobility shift assays showed that Xoc_3982 repressed the transcription of effector xopC2, which contributes to virulence in Xoc BLS256. This study describes how sRNA Xonc3711 modulates multiple traits in Xoc via signals perceived from the external environment.
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http://dx.doi.org/10.1371/journal.ppat.1009762DOI Listing
July 2021

Comparative Whole Genome Sequence Analysis and Biological Features of Sequence Type 2.

Front Microbiol 2021 5;12:651520. Epub 2021 Jul 5.

School of Laboratory Medicine, Hangzhou Medical College, Hangzhou, China.

sequence type 2 (ST2) has been increasingly recognized as one of the major genotypes in China, while the genomic characteristics and biological phenotypes of Chinese ST2 strains remain to be determined. We used whole-genome sequencing and phylogenetic analysis to investigate the genomic features of 182 ST2 strains, isolated between 2011 and 2017. PCR ribotyping (RT) was performed, and antibiotic resistance, toxin concentration, and sporulation capacity were measured. The core genome Maximum-likelihood phylogenetic analysis showed that ST2 strains were distinctly segregated into two genetically diverse lineages [L1 (67.0% from Northern America) and L2], while L2 further divided into two sub-lineages, SL2a and SL2b (73.5% from China). The 36 virulence-related genes were widely distributed in ST2 genomes, but in which only 11 antibiotic resistance-associated genes were dispersedly found. Among the 25 SL2b sequenced isolates, RT014 (40.0%, = 10) and RT020 (28.0%, = 7) were two main genotypes with no significant difference on antibiotic resistance (χ = 0.024-2.667, > 0.05). A non-synonymous amino acid substitution was found in (Y1975D) which was specific to SL2b. Although there was no significant difference in sporulation capacity between the two lineages, the average toxin B concentration (5.11 ± 3.20 ng/μL) in SL2b was significantly lower in comparison to those in L1 (10.49 ± 15.82 ng/μL) and SL2a (13.92 ± 2.39 ng/μL) (χ = 12.30, < 0.05). This study described the genomic characteristics of ST2, with many virulence loci and few antibiotic resistance elements. The Chinese ST2 strains with the mutation in codon 1975 of the gene clustering in SL2b circulating in China express low toxin B, which may be associated with mild or moderate infection.
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http://dx.doi.org/10.3389/fmicb.2021.651520DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8287029PMC
July 2021

Association of fluid balance trajectories with clinical outcomes in patients with septic shock: a prospective multicenter cohort study.

Mil Med Res 2021 07 6;8(1):40. Epub 2021 Jul 6.

Department of Critical Care Medicine, Fuxing Hospital, Capital Medical University, No. 20, Street Fuxingmenwai, Beijing, Xicheng District, China.

Background: Septic shock has a high incidence and mortality rate in Intensive Care Units (ICUs). Earlier intravenous fluid resuscitation can significantly improve outcomes in septic patients but easily leads to fluid overload (FO), which is associated with poor clinical outcomes. A single point value of fluid cannot provide enough fluid information. The aim of this study was to investigate the impact of fluid balance (FB) latent trajectories on clinical outcomes in septic patients.

Methods: Patients were diagnosed with septic shock during the first 48 h, and sequential fluid data for the first 3 days of ICU admission were included. A group-based trajectory model (GBTM) which is designed to identify groups of individuals following similar developmental trajectories was used to identify latent subgroups of individuals following a similar progression of FB. The primary outcomes were hospital mortality, organ dysfunction, major adverse kidney events (MAKE) and severe respiratory adverse events (SRAE). We used multivariable Cox or logistic regression analysis to assess the association between FB trajectories and clinical outcomes.

Results: Nine hundred eighty-six patients met the inclusion criteria and were assigned to GBTM analysis, and three latent FB trajectories were detected. 64 (6.5%), 841 (85.3%), and 81 (8.2%) patients were identified to have decreased, low, and high FB, respectively. Compared with low FB, high FB was associated with increased hospital mortality [hazard ratio (HR) 1.63, 95% confidence interval (CI) 1.22-2.17], organ dysfunction [odds ratio (OR) 2.18, 95% CI 1.22-3.42], MAKE (OR 1.80, 95% CI 1.04-2.63) and SRAE (OR 2.33, 95% CI 1.46-3.71), and decreasing FB was significantly associated with decreased MAKE (OR 0.46, 95% CI 0.29-0.79) after adjustment for potential covariates.

Conclusion: Latent subgroups of septic patients followed a similar FB progression. These latent fluid trajectories were associated with clinical outcomes. The decreasing FB trajectory was associated with a decreased risk of hospital mortality and MAKE.
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http://dx.doi.org/10.1186/s40779-021-00328-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8258941PMC
July 2021

Unique Biomarker Characteristics in Gestational Diabetes Mellitus Identified by LC-MS-Based Metabolic Profiling.

J Diabetes Res 2021 9;2021:6689414. Epub 2021 Jun 9.

Key Laboratory of Neuroscience, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou 511436, China.

Background: Gestational diabetes mellitus (GDM) is a type of glucose intolerance disorder that first occurs during women's pregnancy. The main diagnostic method for GDM is based on the midpregnancy oral glucose tolerance test. The rise of metabolomics has expanded the opportunity to better identify early diagnostic biomarkers and explore possible pathogenesis.

Methods: We collected blood serum from 34 GDM patients and 34 normal controls for a LC-MS-based metabolomics study.

Results: 184 metabolites were increased and 86 metabolites were decreased in the positive ion mode, and 65 metabolites were increased and 71 were decreased in the negative ion mode. Also, it was found that the unsaturated fatty acid metabolism was disordered in GDM. Ten metabolites with the most significant differences were selected for follow-up studies. Since the diagnostic specificity and sensitivity of a single differential metabolite are not definitive, we combined these metabolites to prepare a ROC curve. We found a set of metabolite combination with the highest sensitivity and specificity, which included eicosapentaenoic acid, docosahexaenoic acid, docosapentaenoic acid, arachidonic acid, citric acid, -ketoglutaric acid, and genistein. The area under the curves (AUC) value of those metabolites was 0.984 between the GDM and control group.

Conclusions: Our results provide a direction for the mechanism of GDM research and demonstrate the feasibility of developing a diagnostic test that can distinguish between GDM and normal controls clearly. Our findings were helpful to develop novel biomarkers for precision or personalized diagnosis for GDM. In addition, we provide a critical insight into the pathological and biological mechanisms for GDM.
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http://dx.doi.org/10.1155/2021/6689414DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8211500PMC
June 2021

Validation of the Prediction Accuracy for 13 Traits in Chinese Simmental Beef Cattle Using a Preselected Low-Density SNP Panel.

Animals (Basel) 2021 Jun 25;11(7). Epub 2021 Jun 25.

Laboratory of Molecular Biology and Bovine Breeding, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100193, China.

Chinese Simmental beef cattle play a key role in the Chinese beef industry due to their great adaptability and marketability. To achieve efficient genetic gain at a low breeding cost, it is crucial to develop a customized cost-effective low-density SNP panel for this cattle population. Thirteen growth, carcass, and meat quality traits and a BovineHD Beadchip genotyping of 1346 individuals were used to select trait-associated variants and variants contributing to great genetic variance. In addition, highly informative SNPs with high MAF in each 500 kb sliding window and in each genic region were also included separately. A low-density SNP panel consisting of 30,684 SNPs was developed, with an imputation accuracy of 97.4% when imputed to the 770 K level. Among 13 traits, the average prediction accuracy levels evaluated by genomic best linear unbiased prediction (GBLUP) and BayesA/B/Cπ were 0.22-0.47 and 0.18-0.60 for the ~30 K array and BovineHD Beadchip, respectively. Generally, the predictive performance of the ~30 K array was trait-dependent, with reduced prediction accuracies for seven traits. While differences in terms of prediction accuracy were observed among the 13 traits, the low-density SNP panel achieved moderate to high accuracies for most of the traits and even improved the accuracies for some traits.
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http://dx.doi.org/10.3390/ani11071890DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8300368PMC
June 2021

Isolation, structural properties, bioactivities of polysaccharides from Dendrobium officinale Kimura et. Migo: A review.

Int J Biol Macromol 2021 Aug 29;184:1000-1013. Epub 2021 Jun 29.

School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, PR China. Electronic address:

Dendrobium officinale Kimura et Migo (D. officinale) is used as herbal medicine and new food resource in China, which is nontoxic and harmless, and can be used as common food. Polysaccharide as one of the main bioactive components in D. officinale, mainly composed of glucose and mannose (Manp: Glcp = 2.01:1.00-8.82:1.00), along with galactose, xylose, arabinose, and rhamnose in different molar ratios and types of glycosidic bonds. Polysaccharides of D. officinale exhibit a variety of biological effects, including immunomodulatory, anti-tumor, gastro-protective, hypoglycemic, anti-inflammatory, hepatoprotective, and vasodilating effects. This paper presents the extraction, purification, structural characteristics, bioactivities, structure-activity relationships and analyzes gaps in the current research on D. officinale polysaccharides. In addition, based on in vitro and in vivo experiments, the possible mechanisms of bioactivities of D. officinale polysaccharides were summarized. We hope that this work may provide helpful references and promising directions for further study and development of D. officinale polysaccharides.
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http://dx.doi.org/10.1016/j.ijbiomac.2021.06.156DOI Listing
August 2021

Correction to: Effect of real-time ultrasound imaging for biofeedback on trunk muscle contraction in healthy subjects: a preliminary study.

BMC Musculoskelet Disord 2021 Jun 30;22(1):600. Epub 2021 Jun 30.

Department of Rehabilitation Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, China.

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http://dx.doi.org/10.1186/s12891-021-04429-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8247085PMC
June 2021

A Novel Application of Unsupervised Machine Learning and Supervised Machine Learning-Derived Radiomics in Anterior Cruciate Ligament Rupture.

Risk Manag Healthc Policy 2021 23;14:2657-2664. Epub 2021 Jun 23.

Department of Sports Medicine and Arthroscopy, Tianjin Hospital of Tianjin University, Tianjin, People's Republic of China.

Purpose: We aim to present an unsupervised machine learning application in anterior cruciate ligament (ACL) rupture and evaluate whether supervised machine learning-derived radiomics features enable prediction of ACL rupture accurately.

Patients And Methods: Sixty-eight patients were reviewed. Their demographic features were recorded, radiomics features were extracted, and the input dataset was defined as a collection of demographic features and radiomics features. The input dataset was automatically classified by the unsupervised machine learning algorithm. Then, we used a supervised machine learning algorithm to construct a radiomics model. The -test and least absolute shrinkage and selection operator (LASSO) method were used for feature selection, random forest and support vector machine (SVM) were used as machine learning classifiers. For each model, the sensitivity, specificity, accuracy, and the area under the curve (AUC) of receiver operating characteristic (ROC) curves were calculated to evaluate model performance.

Results: In total, 5 demographic features were recorded and 106 radiomics features were extracted. By applying the unsupervised machine learning algorithm, patients were divided into 5 groups. Group 5 had the highest incidence of ACL rupture and left knee involvement. There were significant differences in left knee involvement among the groups. Forty-three radiomics features were extracted using -test and 7 radiomics features were extracted using LASSO method. We found that the combination of LASSO selection method and random forest classifier has the highest sensitivity, specificity, accuracy, and AUC. The 7 radiomics features extracted by LASSO method were potential predictors for ACL rupture.

Conclusion: We validated the clinical application of unsupervised machine learning involving ACL rupture. Moreover, we found 7 radiomics features which were potential predictors for ACL rupture. The study indicated that radiomics could be a valuable method in the prediction of ACL rupture.
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http://dx.doi.org/10.2147/RMHP.S312330DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8236276PMC
June 2021

Donafenib Versus Sorafenib in First-Line Treatment of Unresectable or Metastatic Hepatocellular Carcinoma: A Randomized, Open-Label, Parallel-Controlled Phase II-III Trial.

J Clin Oncol 2021 Jun 29:JCO2100163. Epub 2021 Jun 29.

School of Public Health, Nanjing Medical University, Nanjing, China.

Purpose: Donafenib, a novel multikinase inhibitor and a deuterated sorafenib derivative, has shown efficacy in phase Ia and Ib hepatocellular carcinoma (HCC) studies. This study compared the efficacy and safety of donafenib versus sorafenib as first-line therapy for advanced HCC.

Patients And Methods: This open-label, randomized, parallel-controlled, multicenter phase II-III trial enrolled patients with unresectable or metastatic HCC, a Child-Pugh score ≤ 7, and no prior systemic therapy from 37 sites across China. Patients were randomly assigned (1:1) to receive oral donafenib (0.2 g) or sorafenib (0.4 g) twice daily until intolerable toxicity or disease progression. The primary end point was overall survival (OS), tested for noninferiority and superiority. Efficacy was primarily assessed in the full analysis set (FAS), and safety was assessed in all treated patients.

Results: Between March 21, 2016, and April 16, 2018, 668 patients (intention-to-treat) were randomly assigned to donafenib and sorafenib treatment arms; the FAS included 328 and 331 patients, respectively. Median OS was significantly longer with donafenib than sorafenib treatment (FAS; 12.1 10.3 months; hazard ratio, 0.831; 95% CI, 0.699 to 0.988; = .0245); donafenib also exhibited superior OS outcomes versus sorafenib in the intention-to-treat population. The median progression-free survival was 3.7 3.6 months ( .0570). The objective response rate was 4.6% 2.7% ( = .2448), and the disease control rate was 30.8% 28.7% (FAS; = .5532). Drug-related grade ≥ 3 adverse events occurred in significantly fewer patients receiving donafenib than sorafenib (125 [38%] 165 [50%]; .0018).

Conclusion: Donafenib showed superiority over sorafenib in improving OS and has favorable safety and tolerability in Chinese patients with advanced HCC, showing promise as a potential first-line monotherapy for these patients.
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http://dx.doi.org/10.1200/JCO.21.00163DOI Listing
June 2021

Perioperative and short-term oncological outcomes following laparoscopic versus open pancreaticoduodenectomy after learning curve in the past 10 years: a systematic review and meta-analysis.

Gland Surg 2021 May;10(5):1655-1668

Department of Liver Surgery and Liver Transplantation Centre, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, China.

Background: To compare perioperative and short-term oncologic outcomes of laparoscopic pancreaticoduodenectomy (LPD) to open pancreaticoduodenectomy (OPD) using data from large-scale retrospective cohorts and randomized controlled trials (RCTs) in the last 10 years.

Methods: A meta-analysis to assess the safety and feasibility of LDP and OPD registered with PROSPERO: (CRD42020218080) was performed according to the PRISMA guidelines. Studies comparing LPD with OPD published between January 2010 and October 2020 were included; only clinical studies reporting more than 30 cases for each operation were included. Two authors performed data extraction and quality assessment independently. The primary endpoint was operative times, blood loss, and 90 days mortality. Secondary endpoints included reoperation, length of hospital stay (LOS), morbidity, Clavien-Dindo ≥3 complications, postoperative pancreatic fistula (POPF), blood transfusion, delayed gastric emptying (DGE), postpancreatectomy hemorrhage (PPH), and oncologic outcomes (R0-resection, lymph node dissection).

Results: Overall, the final analysis included 15 retrospective cohorts and 3 RCTs comprising 12,495 patients (2,037 and 10,458 patients underwent LPD and OPD). It seems OPD has more lymph nodes harvested but no significant differences [weighted mean difference (WMD): 1.08; 95% confidence interval (CI): 0.02 to 2.14; P=0.05]. Nevertheless, compared with OPD, LPD was associated with a higher R0 resection rate [odds ratio (OR): 1.26; 95% CI: 1.10-1.44; P=0.0008] and longer operative time (WMD: 89.80 min; 95% CI: 63.75-115.84; P<0.00001), patients might benefit from lower rate of wound infection (OR: 0.36; 95% CI: 0.33-0.59; P<0.0001), much less blood loss (WMD: -212.25 mL; 95% CI: -286.15 to -138.14; P<0.00001) and lower blood transfusion rate (OR: 0.58; 95% CI: 0.43-0.77; P=0.0002) and shorter LOS (WMD: -1.63 day; 95% CI: -2.73 to -0.51; P=0.004). No significant differences in 90-day mortality, overall morbidity, Clavien-Dindo ≥3 complications, reoperation, POPF, DGE and PPH between LPD and OPD.

Conclusions: Our study suggests that after learning curve, LPD is a safe and feasible alternative to OPD as it provides similar perioperative and acceptable oncological outcomes when compared with OPD.
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http://dx.doi.org/10.21037/gs-20-916DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8184374PMC
May 2021

A retrospective cohort study on red blood cell morphology changes in pre-school age children under nitrous oxide anesthesia.

BMC Anesthesiol 2021 Jun 16;21(1):171. Epub 2021 Jun 16.

Department of Anesthesiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Background: Megaloblastic anemia or bone marrow changes could occur after prolonged nitrous oxide inhalation via vitamin B inactivation related DNA synthesis impairment. Previous researches have studied hematological changes with nitrous oxide exposure, but only in adults or adolescents. Pre-school age children with active hematopoietic red bone marrow are more vulnerable to potential side effects of nitrous oxide and might experience growth impairment. The purpose of our study was to analyze red blood cell morphology changes under nitrous oxide anesthesia in pre-school age children.

Methods: One hundred thirty-six children under 5 years old scheduled for hemivertebra resection were analyzed. According to fresh gas type in anesthesia records, 71 children who received nitrous oxide in oxygen during anesthesia maintenance were categorized into the nitrous oxide group and the other 65 who received air in oxygen were the air group. Complete blood counts in perioperative period were assessed for anemia, macrocytosis, microcytosis, anisocytosis, hyperchromatosis and hypochromatosis. The peak value and change percentage were calculated for mean corpuscular volume and red cell distribution width.

Results: Forty-two children in the air group (64.6%) and 30 in the nitrous oxide group (42.3%) developed anemia (P = 0.009). None developed macrocytosis in both groups. Postoperative mean corpuscular volume peaked (mean [95% confidence interval]) at 83.7(82.9-84.4) fL, and 83.2(82.4-83.9) fL and postoperative red cell distribution width at 13.8% (13.4-14.2%), and 13.9% (13.6-14.2%) for the air group and the nitrous oxide group. Both the relative change of mean corpuscular volume (P = 0.810) and red cell distribution width (P = 0.456) were similar between the two groups.

Conclusions: No megaloblastic red blood cell changes were observed with nitrous oxide exposure for 4 h in pre-school age children undergoing hemivertebra resection.
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http://dx.doi.org/10.1186/s12871-021-01388-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8207597PMC
June 2021

Genomic evolution and virulence association of sequence type 37 (ribotype 017) in China.

Emerg Microbes Infect 2021 Dec;10(1):1331-1345

School of Laboratory Medicine, Hangzhou Medical College, Hangzhou, People's Republic of China.

sequence type (ST) 37 (ribotype 017) is one of the most prevalent genotypes circulating in China. However, its genomic evolution and virulence determinants were rarely explored. Whole-genome sequencing, phylogeographic and phylogenetic analyses were conducted for ST37 isolates. The 325 ST37 genomes from six continents, including North America ( = 66), South America ( = 4), Oceania ( = 7), Africa ( = 9), Europe ( = 138) and Asia ( = 101), were clustered into six major lineages, with region-dependent distributions, harbouring an array of antibiotic-resistance genes. The ST37 strains from China were divided into four distinct sublineages, showing five importation times and international sources. Isolates associated with severe infections exhibited significantly higher toxin productions, mRNA levels, and sporulation capacities ( < 0.001). Kyoto Encyclopedia of Genes and Genomes analysis showed 10 metabolic pathways were significantly enriched in the mutations among isolates associated with severe CDI ( < 0.05). Gene mutations in glycometabolism, amino acid metabolism and biosynthesis virtually causing instability in protein activity were correlated positively to the transcription of and negatively to the expression of toxin repressor genes, and Y. In summary, our study firstly presented genomic insights into genetic characteristics and virulence association of ST37 in China. Gene mutations in certain important metabolic pathways are associated with severe symptoms and correlated with higher virulence in ST37 isolates.
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http://dx.doi.org/10.1080/22221751.2021.1943538DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8253194PMC
December 2021

Enhanced phytoremediation of TNT and cobalt co-contaminated soil by AfSSB transformed plant.

Ecotoxicol Environ Saf 2021 Sep 10;220:112407. Epub 2021 Jun 10.

Biotechnology Research Institute, Shanghai Academy of Agricultural Sciences, Shanghai 201106, China; Shanghai Key Laboratory of Agricultural Genetics and Breeding, Shanghai Academy of Agricultural Sciences, Shanghai 201106, China. Electronic address:

2,4,6-trinitrotoluene (TNT) and cobalt (Co) contaminants have posed a severe environmental problem in many countries. Phytoremediation is an environmentally friendly technology for the remediation of these contaminants. However, the toxicity of TNT and cobalt limit the efficacy of phytoremediation application. The present research showed that expressing the Acidithiobacillus ferrooxidans single-strand DNA-binding protein gene (AfSSB) can improve the tolerance of Arabidopsis and tall fescue to TNT and cobalt. Compared to control plants, the AfSSB transformed Arabidopsis and tall fescue exhibited enhanced phytoremediation of TNT and cobalt separately contaminated soil and co-contaminated soil. The comet analysis revealed that the AfSSB transformed Arabidopsis suffer reduced DNA damage than control plants under TNT or cobalt exposure. In addition, the proteomic analysis revealed that AfSSB improves TNT and cobalt tolerance by strengthening the reactive superoxide (ROS) scavenging system and the detoxification system. Results presented here serve as strong theoretical support for the phytoremediation potential of organic and metal pollutants mediated by single-strand DNA-binding protein genes. SUMMARIZES: This is the first report that AfSSB enhances phytoremediation of 2,4,6-trinitrotoluene and cobalt separately contaminated and co-contaminated soil.
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http://dx.doi.org/10.1016/j.ecoenv.2021.112407DOI Listing
September 2021

LncRNA Bmp1 promotes the healing of intestinal mucosal lesions via the miR-128-3p/PHF6/PI3K/AKT pathway.

Cell Death Dis 2021 Jun 9;12(6):595. Epub 2021 Jun 9.

Department of Burn Surgery, the Affiliated Huaihai Hospital of Xuzhou Medical University, Xuzhou, 221004, Jiangsu Province, China.

Intestinal mucosal injuries are directly or indirectly related to many common acute and chronic diseases. Long non-coding RNAs (lncRNAs) are expressed in many diseases, including intestinal mucosal injury. However, the relationship between lncRNAs and intestinal mucosal injury has not been determined. Here, we investigated the functions and mechanisms of action of lncRNA Bmp1 on damaged intestinal mucosa. We found that Bmp1 was increased in damaged intestinal mucosal tissue and Bmp1 overexpression was able to alleviate intestinal mucosal injury. Bmp1 overexpression was found to influence cell proliferation, colony formation, and migration in IEC-6 or HIEC-6 cells. Moreover, miR-128-3p was downregulated after Bmp1 overexpression, and upregulation of miR-128-3p reversed the effects of Bmp1 overexpression in IEC-6 cells. Phf6 was observed to be a target of miR-128-3p. Furthermore, PHF6 overexpression affected IEC-6 cells by activating PI3K/AKT signaling which was mediated by the miR-128-3p/PHF6 axis. In conclusion, Bmp1 was found to promote the expression of PHF6 through the sponge miR-128-3p, activating the PI3K/AKT signaling pathway to promote cell migration and proliferation.
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http://dx.doi.org/10.1038/s41419-021-03879-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8190101PMC
June 2021

Transcriptome profiling analysis of muscle tissue reveals potential candidate genes affecting water holding capacity in Chinese Simmental beef cattle.

Sci Rep 2021 Jun 7;11(1):11897. Epub 2021 Jun 7.

Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing, 100193, China.

Water holding capacity (WHC) is an important sensory attribute that greatly influences meat quality. However, the molecular mechanism that regulates the beef WHC remains to be elucidated. In this study, the longissimus dorsi (LD) muscles of 49 Chinese Simmental beef cattle were measured for meat quality traits and subjected to RNA sequencing. WHC had significant correlation with 35 kg water loss (r = - 0.99, p < 0.01) and IMF content (r = 0.31, p < 0.05), but not with SF (r = - 0.20, p = 0.18) and pH (r = 0.11, p = 0.44). Eight individuals with the highest WHC (H-WHC) and the lowest WHC (L-WHC) were selected for transcriptome analysis. A total of 865 genes were identified as differentially expressed genes (DEGs) between two groups, of which 633 genes were up-regulated and 232 genes were down-regulated. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment revealed that DEGs were significantly enriched in 15 GO terms and 96 pathways. Additionally, based on protein-protein interaction (PPI) network, animal QTL database (QTLdb), and relevant literature, the study not only confirmed seven genes (HSPA12A, HSPA13, PPARγ, MYL2, MYPN, TPI, and ATP2A1) influenced WHC in accordance with previous studies, but also identified ATP2B4, ACTN1, ITGAV, TGFBR1, THBS1, and TEK as the most promising novel candidate genes affecting the WHC. These findings could offer important insight for exploring the molecular mechanism underlying the WHC trait and facilitate the improvement of beef quality.
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http://dx.doi.org/10.1038/s41598-021-91373-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8184995PMC
June 2021

Genomic and transcriptional alterations in first-line chemotherapy exert a potentially unfavorable influence on subsequent immunotherapy in NSCLC.

Theranostics 2021 13;11(14):7092-7109. Epub 2021 May 13.

Department of Medical Oncology, Shanghai Pulmonary Hospital & Thoracic Cancer Institute, Tongji University School of Medicine, No. 507, Zhengmin Road, Yangpu District, Shanghai 200433, China.

Recent studies in non-small cell lung cancer (NSCLC) patients have demonstrated that first-line immunotherapy is associated with better therapeutic response than second-line treatment. So far, the mechanisms need to be explored. It prompted us to evaluate the association between first-line chemotherapy and subsequent immunotherapy in NSCLC as well as its underlying mechanisms at the genomic and transcriptomic level. We launched a prospective, observational clinical study, paired tumor biopsies before and after chemotherapy were collected from NSCLC patients without tyrosine kinase inhibitor (TKI)-related driver gene mutations. The analyses included genomic and transcriptional changes performed by next-generation sequencing (NGS)-based whole-exome sequencing (WES) and messager ribonucleic acid (mRNA) sequencing. Characteristic mutational alterations in 1574 genes were investigated based on mutational status, clinicopathological factors, and chemotherapy responses. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis, neoantigen prediction and intratumoral heterogeneity evaluation were also performed. Samples and information from 32 NSCLC patients without TKI-related driver gene mutations were obtained. We found that the total number of single nucleotide variants (SNV)/insertion-deletion (INDEL) mutations did not change significantly after chemotherapy. The tumor mutation burden (TMB) decreased significantly after chemotherapy in smoking patients and the decreased TMB correlated with a better survival of smoking patients. The change in copy number variations (CNVs) exhibited a decreasing trend during chemotherapy. Subsequent analysis at mRNA level revealed a significant decrease in the expression levels of genes related to antigen processing and presentation as well as other factors relevant for response to immunotherapy. Pathway enrichment analysis confirmed that the immune-related signaling pathways or biological processes were decreased after first-line chemotherapy. Our study presents an explanation for the unsatisfactory results of immunotherapy when given after chemotherapy, and suggests that first-line chemotherapy is able to influence the tumor microenvironment and decrease the efficacy of subsequent immunotherapy. The study was registered at ClinicalTrials.gov, number NCT03764917, and has completed enrolment; patients are still in follow-up.
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http://dx.doi.org/10.7150/thno.58039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8171101PMC
May 2021

Use of double-lumen tube adaptor to enable cross-field two-lung ventilation through two endotracheal tubes in carinal tumor resection: A case report.

J Clin Anesth 2021 Oct 1;73:110357. Epub 2021 Jun 1.

Department of Anesthesiology, Chinese Academy of Medical Sciences & Peking Union Medical College Hospital, Beijing 100730, China.

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http://dx.doi.org/10.1016/j.jclinane.2021.110357DOI Listing
October 2021

Astragalus polysaccharide attenuates LPS-related inflammatory osteolysis by suppressing osteoclastogenesis by reducing the MAPK signalling pathway.

J Cell Mol Med 2021 Jul 2;25(14):6800-6814. Epub 2021 Jun 2.

Department of Orthopaedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Bacterial products can stimulate inflammatory reaction and activate immune cells to enhance the production of inflammatory cytokines, and finally promote osteoclasts recruitment and activity, leading to bone destruction. Unfortunately, effective preventive and treatment measures for inflammatory osteolysis are limited and usually confuse the orthopedist. Astragalus polysaccharide (APS), the main extractive of Astragali Radix, has been widely used for treating inflammatory diseases. In the current study, in vitro and in vivo experimental results demonstrated that APS notably inhibited osteoclast formation and differentiation dose-dependently. Moreover, we found that APS down-regulated RANKL-related osteoclastogenesis and levels of osteoclast marker genes, such as NFATC1, TRAP, c-FOS and cathepsin K. Further underlying mechanism investigation revealed that APS attenuated activity of MAPK signalling pathways (eg ERK, JNK and p38) and ROS production induced by RANKL. Additionally, APS was also found to suppress LPS-related inflammatory osteolysis by decreasing inflammatory factors' production in vivo. Overall, our findings demonstrate that APS effectively down-regulates inflammatory osteolysis due to osteoclast differentiation and has the potential to become an effective treatment of the disorders associated with osteoclast.
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http://dx.doi.org/10.1111/jcmm.16683DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8278124PMC
July 2021

Effect of Glycemic Gap upon Mortality in Critically Ill Patients with Diabetes.

J Diabetes Investig 2021 Jun 2. Epub 2021 Jun 2.

Department of Crtical Care Medicine, Fu Xing Hospital, Capital Medical University, 20A Fuxingmenwai Street, Xicheng District Beijing, 100038, China.

Objectives: Hyperglycemia, hypoglycemia and blood glucose fluctuation are associated with the outcomes in critically ill patients, but target of blood glucose control is debatable especially in patients with diabetes regarding to the situation of blood glucose control before admission to ICU. This study is aimed to investigate the association between glycemic gap which is calculated as the mean blood glucose level during the first 7 days after admission to ICU minus the A1C-derived average glucose and outcomes of critically ill patients with diabetes.

Method: This study undertaken in two intensive care units (ICUs) with a total of 30 beds. Patients with diabetes expected to stay for more than 24hrs were enrolled, HbA1c was tested within 3 days after admission and converted to the A1C-derived average glucose (ADAG) by the equation: ADAG = [ ( HbA1c * 28.7 ) - 46.7 ] * 18-1, arterial blood glucose measurements were fourth per day routinely during the first 7 days after admission, APACHE II score within first 24 hours, the mean blood glucose level(MGL), standard deviation(SD), and coefficient of variation(CV) during first 7 days were calculated for each person, GAPadm and GAPmean were calculated as admission blood glucose and MGL minus ADAG respectively, the incidence of moderate hypoglycemia(MH) and severe hypoglycemia(SH), total dosage of glucocorticoids and average daily dosage of insulin within 7 days, duration of renal replacement therapy(RRT), ventilator-free hours, and non-ICU stay days within 28 days were also collected. Patients enrolled were divided into survival group and nonsurvival group according to survival or not at 28-day and 1-year after admission, exploration of the relationship between parameters derived from blood glucose and mortality in critically ill patients enrolled were undergone.

Results: 502 patients were enrolled and divided into survival group (n=310) and nonsurvival group (n=192). It was shown that two groups had comparable level of HbA1c, the nonsurvivors had greater APACHE II, MGL, SD, CV, GAP , GAP , and higher hypoglycemia incidences. Less duration of ventilator-free, non-ICU stay, and longer duration of RRT were recorded in nonsurvival group, of whom received less carbohydrate intake, higher insulin daily dosage, and glucocorticoid dosage. GAP had the greatest predictive power with AUC of 0.820(95%CI: 0.781-0.850), the cut-off value was 3.60mmol/L(sensitivity 78.2% and specificity 77.3%). Patients with low GAP tended to survive longer than the high GAP group 1 year after admission.

Conclusion: Glycemic GAP between the mean level of blood glucose within first 7 days after admission to ICU and A1C-derived average glucose was independently associated with 28-day mortality of critically ill patients with diabetes, the predictive power extended to 1 year. The incidence of hypoglycemia was associated with mortality either.
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http://dx.doi.org/10.1111/jdi.13606DOI Listing
June 2021

Comparative Evaluation of Microbiota Dynamics and Metabolites Correlation Between Spontaneous and Inoculated Fermentations of Nanfeng Tangerine Wine.

Front Microbiol 2021 11;12:649978. Epub 2021 May 11.

College of Life Sciences, Gannan Normal University, Ganzhou, China.

Understanding the evolution of microorganisms and metabolites during wine fermentation is essential for controlling its production. The structural composition and functional capacity of the core microbiota determine the quality and quantity of fruit wine. Nanfeng tangerine wine fermentation involves a complex of various microorganisms and a wide variety of metabolites. However, the microbial succession and functional shift of the core microbiota in this product fermentation remain unclear. Therefore, high-throughput sequencing (HTS) and headspace-gas chromatography-mass spectrometry (HS/GC-MS) were employed to reveal the core functional microbiota for the production of volatile flavors during spontaneous fermentation (SF) and inoculated fermentation (IF) with of Nanfeng tangerine wine. A total of 13 bacterial and 8 fungal genera were identified as the core microbiota; and were the dominant bacteria in SF and IF, respectively. The main fungal genera in SF and IF were , , and with a clear succession. In addition, the potential correlations analysis between microbiota succession and volatile flavor dynamics revealed that , , , and were the major contributors to the production of the volatile flavor of Nanfeng tangerine wine. The results of the present study provide insight into the effects of the core functional microbiota in Nanfeng tangerine wine and can be used to develop effective strategies for improving the quality of fruit wines.
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http://dx.doi.org/10.3389/fmicb.2021.649978DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8144288PMC
May 2021

[Sources Apportionment of Oxygenated Volatile Organic Compounds (OVOCs) in a Typical Southwestern Region in China During Summer].

Huan Jing Ke Xue 2021 Jun;42(6):2648-2658

Research Center for Atmospheric Environment, Chongqing Institute of Green and Intelligent Technology, Chinese Academy of Sciences, Chongqing 400714, China.

Oxygenated volatile organic compounds (OVOCs) are important intermediates in the troposphere and the most important sources of ozone. Proton-transfer-reaction time-of-flight mass spectrometry (PTR-TOF-MS) was used to measure VOCs in the Chengdu Plain, Southwestern China. The diurnal variations, photochemical reactivity, O formation potential, and sources were also investigated. The mixing ratios of ten kinds of VOCs (acetaldehyde, acetone, isoprene, Methyl ethyl ketone, Methyl vinyl ketone and Methacrolein, benzene, toluene, styrene, C8 aromatics, and C9 aromatics) were (10.97±4.69)×10. The concentrations of OVOCs, aromatic hydrocarbons, and biogenic VOCs were (8.54±3.44)×10, (1.53±0.93)×10, and (0.90±0.32)×10, respectively. Isoprene, acetaldehyde, and m-xylene were the top three photochemically active species with the greatest O formation potentials. The dominant three OVOCs species (acetaldehyde, acetone, and MEK) were mainly derived from local biogenic sources and anthropogenic secondary sources, and acetone had a strong regional background level, indicating that pollution in this area is significantly affected by regional transmission. This study deepens the understanding of regional O formation mechanisms in southwest China and provides a basis for the scientifically informed control of O pollution.
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http://dx.doi.org/10.13227/j.hjkx.202010101DOI Listing
June 2021

Clinical characteristics and outcomes of mechanically ventilated elderly patients in intensive care units: a Chinese multicentre retrospective study.

J Thorac Dis 2021 Apr;13(4):2148-2159

Department of Critical Care Medicine, Fu Xing Hospital, Capital Medical University, Beijing, China.

Background: In recent years, the number of elderly patients receiving mechanical ventilation (MV) in intensive care units (ICUs) has increased. However, the evidence on the outcomes of elderly mechanically ventilated patients is scant in China. Our objective was to evaluate the characteristics and outcomes in elderly patients (≥65 years) receiving MV in the ICU.

Methods: We performed a multicentre retrospective study involving adult patients who were admitted to the ICU and received at least 24 hours of MV. Patients were divided into three age groups: under 65, 65-79, and ≥80 years. The primary outcome was hospital mortality. We performed univariate and multivariate logistic regression analysis to identify factors associated with hospital mortality.

Results: A total of 853 patients were analysed. Of those, 61.5% were ≥65 years of age, and 26.0% were ≥80 years of age. There were significant differences in the principal reason for MV among the three age groups (P<0.001). Advanced age was significantly associated with total duration of MV, ICU length of stay (LOS), and ICU costs (all P<0.001), but not with hospital LOS and hospital costs (P>0.05). In addition, mortality rates in the ICU, hospital, and at 60 days significantly increased with age (all P<0.001). In the age group of 80 years and older, the mortality rates were 47.7%, 49.5%, and 50.0%, respectively. Multivariate logistic regression analysis had found that age, Acute Physiology and Chronic Health Evaluation (APACHE) II score, partial pressure of oxygen in arterial blood/fraction of inspired oxygen (PaO/FiO) ratio, total duration of MV, ICU LOS, and the decision to withhold/withdraw life-sustaining treatments were independent influence factors for mortality rates.

Conclusions: Mechanically ventilated elderly patients (≥65 years) have a higher ICU and hospital mortality, but the hospital LOS and hospital costs are similar to younger patients. Advanced age should be considered as a significant independent risk factor for hospital mortality of mechanically ventilated ICU patients.
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http://dx.doi.org/10.21037/jtd-20-2748DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8107518PMC
April 2021

Low temperature pickling regeneration process for remarkable enhancement in Cu(II) adsorptivity over spent activated carbon fiber.

Chemosphere 2021 Oct 13;281:130868. Epub 2021 May 13.

School of Mechanical, Electrical & Information Engineering Shandong University, Weihai, 264209, China. Electronic address:

In this paper, a simple and efficient regeneration technology of low-temperature pickling regeneration process is proposed for Cu(II)-adsorbed activated carbon fiber felts (ACFFs). The regeneration process mainly uses the strong oxidation of acidic regenerant above boiling point to regenerate ACFFs in a confined space. With no demand for high temperature and high pressure, the regeneration process achieves a high efficiency regeneration and a remarkable enhancement of Cu(II) adsorptivity simultaneously for Cu(II)-adsorbed ACFFs. After parameter optimization, the pickling temperature of 383 K, pickling time of 3 h and HNO concentration of 150 g/L are adopted as optimum process parameters for the reutilization of ACFFs. The regeneration rates of ACFFs in five cycles are maintained at 424.08%-829.59%. Analytical results show that the enhancement of Cu(II) adsorptivity is mainly caused by the remarkable enhancement of specific surface area (increased by 106.08%), micropore volume (increased by 102.17%) and more abundant surface chemical structure (particularly carboxyl and nitro group) after treated by the regeneration process.
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http://dx.doi.org/10.1016/j.chemosphere.2021.130868DOI Listing
October 2021

Correction to: Bacillus subtilis Y16 and biogas slurry enhanced potassium to sodium ratio and physiology of sunflower (Helianthus annuus L.) to mitigate salt stress.

Environ Sci Pollut Res Int 2021 Aug;28(29):38648

Key Laboratory of Urban Agriculture by Ministry of Agriculture of China, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, 200240, People's Republic of China.

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http://dx.doi.org/10.1007/s11356-021-14344-0DOI Listing
August 2021
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