Publications by authors named "Bo Peng"

953 Publications

Metformin attenuates LPS-induced neuronal injury and cognitive impairments by blocking NF-κB pathway.

BMC Neurosci 2021 Nov 26;22(1):73. Epub 2021 Nov 26.

Department of Critical Care Medicine, Renmin Hospital of Wuhan University, Wuhan, China.

Background: Neuroinflammatory response is considered to be a high-risk factor for cognitive impairments in the brain. Lipopolysaccharides (LPS) is an endotoxin that induces acute inflammatory responses in injected bodies. However, the molecular mechanisms underlying LPS-associated cognitive impairments still remain unclear.

Methods: Here, primary hippocampal neurons were treated with LPS, and western blotting and immunofluorescence were used to investigate whether LPS induces neurons damage. At the same time, SD rats were injected with LPS (830 μg/Kg) intraperitoneally, and Open field test, Novel Objective Recognition test, Fear condition test were used to detect cognitive function. LTP was used to assess synaptic plasticity, and molecular biology technology was used to assess the NF-κB pathway, while ELISA was used to detect inflammatory factors. In addition, metformin was used to treat primary hippocampal neurons, and intraventricularly administered to SD rats. The same molecular technics, behavioral and electrophysiological tests were used to examine whether metformin could alleviate the LPS-associated neuronal damage, as well as synaptic plasticity, and behavioral alterations in SD rats.

Results: Altogether, neuronal damage were observed in primary hippocampal neurons after LPS intervention, which were alleviated by metformin treatment. At the same time, LPS injection in rat triggers cognitive impairment through activation of NF-κB signaling pathway, and metformin administration alleviates the LPS-induced memory dysfunction and improves synaptic plasticity.

Conclusion: These findings highlight a novel pathogenic mechanism of LPS-related cognitive impairments through activation of NF-κB signaling pathway, and accumulation of inflammatory mediators, which induces neuronal pathologic changes and cognitive impairments. However, metformin attenuates LPS-induced neuronal injury and cognitive impairments by blocking NF-κB pathway.
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http://dx.doi.org/10.1186/s12868-021-00678-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8626880PMC
November 2021

Six Oligosaccharides' Variation in Breast Milk: A Study in South China from 0 to 400 Days Postpartum.

Nutrients 2021 Nov 11;13(11). Epub 2021 Nov 11.

Tianjin Key Laboratory of Food Science and Health, School of Medicine, Nankai University, Tianjin 300071, China.

This study investigated the variation in oligosaccharide levels in the breast milk of south Chinese mothers in a prolonged breastfeeding period of up to 400 days postpartum. A total of 488 breast milk samples were collected from 335 healthy mothers at five different time points: 0-5 days, 10-15 days, 40-45 days, 200-240 days, and 300-400 days postpartum. A high-performance anion-exchange chromatography-pulsed amperometric detector (HPAEC-PAD) was used to quantify 2'-fucosyllactose (2'-FL), 3-fucosyllactose (3-FL), lacto-N-tetraose (LNT), lacto-N-neotetraose (LNnT), 3'-sialyllactose (3'-SL) and 6'-sialyllactose (6'-SL). In this study, we found six oligosaccharides that were present in breast milk from 0 to 400 days postpartum. The median value ranges of individual oligosaccharide components in this study were 1013-2891 mg/L 2'-FL, 193-1421 mg/L 3-FL, 314-1478 mg/L LNT, 44-255 mg/L LNnT, 111-241 mg/L 3'-SL, and 23-602 mg/L6'-SL. HMO levels decreased over the lactation periods, except for 3-FL, which increased throughout lactation. The predominant fucosylated and sialylated HMOs were 2'-FL and 6'-SL at 40-45 days postpartum and changed to 3-FL and 3'-SL at 200-240 days postpartum. Results from this study showed that lactating women continue to provide their offspring with a high level of 2'-FL one year after delivery, suggesting that 2'-FL may play an important role for infants in early life. Our findings also provide further evidence in support of breastfeeding after one-year postpartum.
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http://dx.doi.org/10.3390/nu13114017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8623037PMC
November 2021

2-Amino-3-Methylimidazo[4,5-f]quinoline Triggering Liver Damage by Inhibiting Autophagy and Inducing Endoplasmic Reticulum Stress in Zebrafish ().

Toxins (Basel) 2021 Nov 22;13(11). Epub 2021 Nov 22.

Tianjin Key Laboratory of Food Science and Health, School of Medicine, Nankai University, Tianjin 300071, China.

It is important to note that 2-Amino-3-methylimidazole[4,5-f]quinoline (IQ) is one of the most common heterocyclic amines (HCAs), which is a class of mutagenic/carcinogenic harmful compounds mainly found in high-protein thermal processed foods and contaminated environments. However, the pre-carcinogenic toxicity of IQ to the liver and its mechanism are poorly understood, further research is needed. In light of this, we exposed zebrafish to IQ (0, 8, 80, and 800 ng/mL) for 35 days, followed by comprehensive experimental studies. Histopathological and ultrastructural analysis showed that hepatocytes were damaged. TUNEL results showed that IQ induced apoptosis of liver cells, the expression of apoptosis factor gene was significantly increased, and the expression of Bcl-2 protein was significantly decreased. In addition, upregulated expression of the 78-kDa glucose-regulated protein (GRP78) and C/EBP homologous protein (CHOP) and endoplasmic reticulum stress (ERS)-related factors transcription levels were elevated obviously, suggesting that IQ induced ERS. Decreased protein expression of autophagy-related 5 (Atg5)-Atg12, Beclin1, and LC3-II, increased protein expression of p62, and autophagy-related factors transcription levels were significantly decreased, suggesting that IQ inhibited autophagy. Overall, our research showed that the potential harm of IQ to the liver before the occurrence of liver cancer was related to ERS and its mediated autophagy and apoptosis pathways.
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http://dx.doi.org/10.3390/toxins13110826DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8620671PMC
November 2021

Elevated REG3α predicts refractory aGVHD in patients who received steroids-ruxolitinib as first-line therapy.

Ann Hematol 2021 Nov 23. Epub 2021 Nov 23.

Medical School of Chinese PLA, Beijing, 100853, China.

We started a single-arm, phase II, open-label, prospective clinical trial using steroids-ruxolitinib as the first-line therapy for intermediate- to high-risk aGVHD (NCT04397367). Here, we report the association of a biomarker panel (sST2, REG3α, sTNFR1, IL-6 and IL-8) with responses to GVHD therapy. The novel first-line therapy for 39 patients with newly diagnosed aGVHD consisted of 1 mg/kg methylprednisolone and 5 mg/day ruxolitinib. The serum concentrations of the biomarkers were prospectively detected at planned time points. Of the 39 patients, the complete response rate at day 28 was 82.05%. In patients who achieved CR, the concentrations of REG3α (P = 0.01; P = 0.10) and sTNFR1 (P = 0.42; P = 0.04) declined at day 14 and day 28 compared with the pre-enrolment levels. In refractory patients, the levels of REG3α at day 14 were higher than those pre-enrolment (P = 0.04). REG3α (P = 0.02) was elevated in the refractory patients compared with the patients achieving CR at day 14 after enrolment, while there was no significant difference in the levels of sST2, sTNFR1 or IL-6. Elevated REG3α levels may predict refractory aGVHD after novel first-line therapy with steroids-ruxolitinib.
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http://dx.doi.org/10.1007/s00277-021-04727-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8610441PMC
November 2021

Two-photon fluorogenic probe for visualizing PGP-1 activity in inflammatory tissues and serum from patients.

Chem Commun (Camb) 2021 Nov 24. Epub 2021 Nov 24.

Frontiers Science Center for Flexible Electronics, Xi'an Institute of Flexible Electronics (IFE) and Xi'an Institute of Biomedical Materials & Engineering, Northwestern Polytechnical University, 127 West Youyi Road, Xi'an 710072, P. R. China.

A PGP-1-specific one/two-photon fluorogenic probe (BH1), capable of high sensitivity, super selectivity, and visual imaging of endogenous PGP-1 activity from live mammalian cells and serum/skin tissues from patients by using one/two-photon fluorescence microscopy (O/TPFM).
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http://dx.doi.org/10.1039/d1cc05290jDOI Listing
November 2021

Unusual Site-Selective Doping in Layered Cathode Strengthens Electrostatic Cohesion of Alkali-Metal Layer for Practicable Sodium-ion Full Cell.

Adv Mater 2021 Nov 22:e2103210. Epub 2021 Nov 22.

Hefei National Laboratory for Physical Sciences at the Microscale, CAS Key Laboratory of Materials for Energy Conversion, Department of Materials Science and Engineering, University of Science and Technology of China, Hefei, Anhui, 230026, China.

P2-type Na Ni Mn O is a dominant cathode material for sodium-ion batteries (SIBs) due to its high theoretical capacity and energy density. However, charging P2-type Na Ni Mn O to voltages higher than 4.2 V versus Na /Na could induce detrimental structural transformation and severe capacity fading. Herein, we achieve stable cycling and moisture resistancy of Na Ni Mn O at 4.35 V (versus Na /Na) through dual-site doping with Cu ion at transition metal site (2a) and unusual Zn ion at Na site (2d), for the first time. The Cu ion doping in 2a site stabilizes the metal layer, while more importantly, the unusual alkali-metal site doping by Zn ion serves as O -Zn -O "pillar" for enhancing electrostatic cohesion between two adjacent transition metal layers, preventing the crack of active material along a-b plane and restraining the generation of O2 phase upon deep desodiation. This unique dual-site doped [Na Zn ]Ni Cu Mn O cathode exhibits a prominent cyclability with 80.6% capacity retention over 2000 cycles at an ultrahigh rate of 10C, demonstrating its great potential for practical applications. Impressively, the full cell devices with [Na Zn ]Ni Cu Mn O and commercial hard carbon as cathode and anode, respectively, can deliver a high energy density of 217.9 Wh kg and excellent cycle life over 1000 cycles. This article is protected by copyright. All rights reserved.
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http://dx.doi.org/10.1002/adma.202103210DOI Listing
November 2021

Multispecies and individual gas molecule detection using Stokes solitons in a graphene over-modal microresonator.

Nat Commun 2021 Nov 18;12(1):6716. Epub 2021 Nov 18.

Key Laboratory of Optical Fiber Sensing and Communications (Education Ministry of China), University of Electronic Science and Technology of China, Chengdu, 611731, China.

Soliton frequency combs generate equally-distant frequencies, offering a powerful tool for fast and accurate measurements over broad spectral ranges. The generation of solitons in microresonators can further improve the compactness of comb sources. However the geometry and the material's inertness of pristine microresonators limit their potential in applications such as gas molecule detection. Here, we realize a two-dimensional-material functionalized microcomb sensor by asymmetrically depositing graphene in an over-modal microsphere. By using one single pump, spectrally trapped Stokes solitons belonging to distinct transverse mode families are co-generated in one single device. Such Stokes solitons with locked repetition rate but different offsets produce ultrasensitive beat notes in the electrical domain, offering unique advantages for selective and individual gas molecule detection. Moreover, the stable nature of the solitons enables us to trace the frequency shift of the dual-soliton beat-note with uncertainty <0.2 Hz and to achieve real-time individual gas molecule detection in vacuum, via an optoelectronic heterodyne detection scheme. This combination of atomically thin materials and microcombs shows the potential for compact photonic sensing with high performances and offers insights toward the design of versatile functionalized microcavity photonic devices.
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http://dx.doi.org/10.1038/s41467-021-26740-8DOI Listing
November 2021

Prognostic Value of Lymphocyte-C-Reactive Protein Ratio in Patients Undergoing Radical Cystectomy for Bladder Cancer: A Population-Based Study.

Front Oncol 2021 28;11:760389. Epub 2021 Oct 28.

Department of Urology, Shanghai Putuo District People's Hospital, Tongji University, Shanghai, China.

Purpose: This study aimed to assess the prognostic value of the lymphocyte-C-reactive protein ratio (LCR) in patients with bladder cancer (BCa) who underwent radical cystectomy (RC).

Materials And Methods: BCa patients between 2009 and 2018 were retrieved from our medical center. The predictive value of LCR on survival of BCa patients was evaluated through the Kaplan-Meier survival and receiver operating characteristic (ROC) curves. The multivariate Cox regression results were used for conducting the nomogram, which were further verified by ROC, decision curve analysis (DCA), and calibration curves. Propensity score matching (PSM) was performed to validate our findings.

Results: A total of 201 BCa patients who received RC were included in this study, with 62 (30.8%) patients in the low LCR group and 139 (69.2%) in the high LCR group. Multivariate analysis results revealed that the high LCR group was significantly related to better prognosis and functioned as a prognostic biomarker for overall survival (OS) [hazard ratio (HR) = 0.41, 95% CI, 0.26-0.66; < 0.001] and disease-free survival (DFS) [HR = 0.40, 95% CI, 0.26-0.66; < 0.001]. The nomogram processed better predictive capability and accuracy than TNM stage from ROC results (AUC = 0.754 . AUC = 0.715), with the confirmation of calibration curves and DCA. The result of PSM confirmed that LCR was significantly correlated with OS and DFS.

Conclusion: Our finding demonstrates that LCR is a novel, convenient, and effective predictor that may provide vital assistance for clinical decision and individualized therapy in BCa patients after RC.
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http://dx.doi.org/10.3389/fonc.2021.760389DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8581644PMC
October 2021

Outcome analysis of early surgery and conservative treatment in neonates and infants with severe hydronephrosis.

J Int Med Res 2021 Nov;49(11):3000605211057866

The Second Department of Pediatric Urology Surgery, Anhui Provincial Children's Hospital, Children's Hospital of Fudan University-Anhui Campus, Hefei, China.

Objective: The treatment strategy and timing of ureteropelvic junction obstruction (UPJO) in infants remain controversial. This study aimed to compare the effect of early surgical treatment (EST) and conservative treatment (CT) on neonates and infants with UPJO and their recovery of renal function and morphology.

Methods: Eighty neonates and infants with severe hydronephrosis were enrolled in this study. They received early pyeloureteroplasty or CT. Diethylenetriamine pentaacetate was used to assess renal function.

Results: There were no significant differences in renal function or renal indices at baseline between the two groups. At 3 and 6 months of follow-up, the anteroposterior diameter of the renal pelvis and the Society of Fetal Urology grade in the EST surgery group were significantly lower compared with those at baseline. The thickness of the renal cortex was greater in the EST group than in the CT group at 3 and 6 months of follow-up. After follow-up for 6 months, renal function in the EST group was significantly better than that in the CT group.

Conclusion: EST accelerates the recovery of renal morphological and functional indices in neonates and infants with severe hydronephrosis.
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http://dx.doi.org/10.1177/03000605211057866DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8593311PMC
November 2021

Evolutionary metabolic landscape from preneoplasia to invasive lung adenocarcinoma.

Nat Commun 2021 11 10;12(1):6479. Epub 2021 Nov 10.

School of Pharmaceutical Sciences, Tsinghua-Peking Center for Life Sciences, Beijing Frontier Research Center for Biological Structure, Tsinghua University, Beijing, 100084, China.

Metabolic reprogramming evolves during cancer initiation and progression. However, thorough understanding of metabolic evolution from preneoplasia to lung adenocarcinoma (LUAD) is still limited. Here, we perform large-scale targeted metabolomics on resected lesions and plasma obtained from invasive LUAD and its precursors, and decipher the metabolic trajectories from atypical adenomatous hyperplasia (AAH) to adenocarcinoma in situ (AIS), minimally invasive adenocarcinoma (MIA) and invasive adenocarcinoma (IAC), revealing that perturbed metabolic pathways emerge early in premalignant lesions. Furthermore, three panels of plasma metabolites are identified as non-invasive predictive biomarkers to distinguish IAC and its precursors with benign diseases. Strikingly, metabolomics clustering defines three metabolic subtypes of IAC patients with distinct clinical characteristics. We identify correlation between aberrant bile acid metabolism in subtype III with poor clinical features and demonstrate dysregulated bile acid metabolism promotes migration of LUAD, which could be exploited as potential targetable vulnerability and for stratifying patients. Collectively, the comprehensive landscape of the metabolic evolution along the development of LUAD will improve early detection and provide impactful therapeutic strategies.
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http://dx.doi.org/10.1038/s41467-021-26685-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8580984PMC
November 2021

Self-paced learning and privileged information based KRR classification algorithm for diagnosis of Parkinson's disease.

Neurosci Lett 2022 Jan 29;766:136312. Epub 2021 Oct 29.

Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Science, Suzhou 215163, China; Jinan Guoke Medical Engineering Technology Development co., LTD, Jinan 250000, China. Electronic address:

Computer aided diagnosis (CAD) methods for Parkinson's disease (PD) can assist clinicians in diagnosis and treatment. Magnetic resonance imaging (MRI) based CAD methods can help reveal structural changes in brain. Classifier is a key component in CAD system, which directly affects the classification performance. Privileged information (PI) can assist to train the classifier by providing additional information, which makes test samples have less error and improves the classification accuracy. In this paper, we proposed a PI based kernel ridge regression plus (KRR+) in diagnosis of PD. Specifically, morphometric features and brain network features are extracted from MRI. Then, empirical kernel mapping feature expression method is used to make the data separable in high-dimensional space. Besides, we introduce self-paced learning that can adaptively select the sample in training of the model, which can further improve the classification performance. The experimental results show that the proposed method is effective for PD diagnosis, its performance is superior to existing classification model. This method is helpful to assist clinicians to find out possible neuroimaging biomarkers in the diagnosis of PD.
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http://dx.doi.org/10.1016/j.neulet.2021.136312DOI Listing
January 2022

ciRS-7 is a prognostic biomarker and potential gene therapy target for renal cell carcinoma.

Mol Cancer 2021 11 5;20(1):142. Epub 2021 Nov 5.

Department of Urology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, No. 301, Yanchang Road, Jing'an District, Shanghai, 200072, China.

Circular RNAs are a new class of non-coding RNAs that have been shown to play critical roles in the development and progression of renal cell carcinoma (RCC). However, little is known about the functional mechanisms and therapeutic role of ciRS-7 in RCC. A series of in vitro and in vivo experiments were performed to investigate the functional mechanism and therapeutic role of ciRS-7, such as real-time quantitative PCR, CCK-8, wound healing, transwell, colony formation, Edu, tumor xenograft and lung metastasis in NSG mice. RNA pull-down, dual luciferase reporter, fluorescence in situ hybridization (FISH) and rescue assays were used to determine the relationship between ciRS-7, miR-139-3p and TAGLN. In addition, we constructed PBAE/si-ciRS-7 nanocomplexes with PBAE material to evaluate the therapeutic effect of the nanocomplexes on tumor in vivo. ciRS-7 was highly expressed in RCC tumor tissues and cell lines, and high ciRS-7 expression correlated with tumor size, high Fuhrman grade and poor survival. Depletion of ciRS-7 significantly inhibited RCC cell proliferation, invasion, tumor growth and metastasis in vivo, while overexpression of ciRS-7 had the opposite effect. Mechanistically, ciRS-7 acts as a "ceRNA" for miR-139-3p to prevent TAGLN degradation and promoting RCC progression and metastasis via the PI3K/AKT signaling pathway. In addition, miR-139-3p mimics or inhibitor could reverse the altered malignant tumor behavior caused by ciRS-7 overexpression or silencing. Furthermore, the PBAE/siciRS-7 nanocomplexes could significantly inhibit RCC tumor progression and metastasis in vivo. ciRS-7 acts as a tumor promoter by regulating the miR-139-3p/TAGLN axis and activating the PI3K/AKT signaling pathway to promote RCC progression and metastasis. Drug development of PBAE/si-ciRS-7 nanocomplexes targeting ciRS-7 may represent a promising gene therapeutic strategy for RCC.
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http://dx.doi.org/10.1186/s12943-021-01443-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8570002PMC
November 2021

A flexible photoelectrochemical aptasensor using heterojunction architecture of α-FeO/d-CN for ultrasensitive detection of penbritin.

Biosens Bioelectron 2021 Oct 30;197:113734. Epub 2021 Oct 30.

College of Environmental Science and Engineering, Hunan University, Changsha, 410082, Hunan, China; Key Laboratory of Environmental Biology and Pollution Control (Hunan University), Ministry of Education, Changsha, 410082, Hunan, China.

The performance of photoelectrochemical (PEC) analysis system relies closely on the properties of the photoelectric electrodes. It is of great significance to integrate photoactive materials with flexible substrates to construct ultra-sensitive PEC sensors for practical application. This work reports a novel photoelectrode developed by immobilizing α-FeO nanoparticles (NPs)/defect-rich carbon nitride (d-CN), an excellent Z-scheme heterojunction photoelectric material, onto three-dimensional (3D) flexible carbon fiber textile. Specifically, 3D hierarchical structure of flexible carbon fiber textile provides larger specific surface area and higher mechanical strength than traditional electrodes, resulting in more reaction sites and faster reaction kinetics to achieve signal amplification. Simultaneously, α-FeO/d-CN Z-scheme heterojunction exhibits enhanced light absorption capability and high redox ability, thus dramatically improving the PEC performance. This photoelectrode was used to construct a flexible PEC aptasensor for ultrasensitive detection of penbritin, demonstrating excellent performance in terms of wide linear range (0.5 pM-50 nM), low detection limit (0.0125 pM) and high stability. The design principle is applicable to the manufacture of other photoelectric sensing systems, which provides an avenue for the development of portable environmental analysis and field diagnostics equipment.
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http://dx.doi.org/10.1016/j.bios.2021.113734DOI Listing
October 2021

Heparin modification improves the re-endothelialization and angiogenesis of decellularized kidney scaffolds through antithrombosis and anti-inflammation .

Transl Androl Urol 2021 Sep;10(9):3656-3668

Department of Urology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.

Background: Constructing tissue-engineered kidneys using decellularized kidney scaffolds (DKS) has attracted widespread attention as it is expected to be the key to solving the shortage of donor kidneys. However, thrombosis and the host inflammatory response are unfavorable factors that hider the re-endothelialization and vascularization of the decellularized scaffolds.

Methods: Heparin was immobilized into the DKS using the method of 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide/N-hydroxysuccinimide (EDC/NHS) activation. Fourier-transform infrared (FTIR) spectra were used to verify the heparinization of DKS. Human umbilical vein endothelial cells (HUVECs) were seeded and cultured in the DKS, then the sliced scaffolds were transplanted subcutaneously into nude mouse. Scanning electron microscopy and a series of histochemical stains including hematoxylin and eosin (H&E), elastic Verhöeff-Van Gieson (EVG), Sirius red, Masson's trichrome, and toluidine blue (TB) staining were used for morphological characterization. The qRT-PCR analysis, immunohistochemistry (IHC), and immunofluorescence (IF) staining were used to determine the expression of related molecular markers.

Results: The rat DKS completely retained the extracellular matrix and heparinized modification. The H&E staining results showed there were more HUVECs covering the internal surfaces of tubular structures in the HEP-DKS group compared with the DKS group. The IF analysis results revealed that CD31, Ki67, and CD206 had higher positive rates in HUVECs in the HEP-DKS group compared to the DKS group. Both groups of scaffolds showed blood vessel formation via H&E staining, and there were more blood vessels in the HEP-DKS group compared with the native DKS group (P<0.05). The qRT-PCR results showed that the levels of IL-1β, IL-6, and TNF-α in the HEP-DKS group were significantly lower than those of the native DKS group, while the expression level of IL-10 was significantly higher than that in the native DKS group (P<0.05).

Conclusions: Heparin modification improves the re-endothelialization and vascular regeneration of the DKS through anticoagulation and . The anti-inflammatory effect of heparin on the transplanted host was initially confirmed, and it is considered that this effect may play a non-negligible role in promoting DKS re-endothelialization and angiogenesis. Heparinized DKS is therefore a promising candidate for kidney tissue engineering.
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http://dx.doi.org/10.21037/tau-21-703DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8511541PMC
September 2021

Single-Atom Ru on AlO for Highly Active and Selective 1,2-Dichloroethane Catalytic Degradation.

ACS Appl Mater Interfaces 2021 Nov 2;13(45):53683-53690. Epub 2021 Nov 2.

State Key Lab of Organic-Inorganic Composites and Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing University of Chemical Technology, Beijing 100029, China.

1,2-Dichloroethane (1,2-DCE) is a toxic volatile organic compound, which is harmful to the environment and human health. Herein, we develop a single-atom Ru catalyst anchored on the mesoporous schistose γ-AlO (Ru SACs/m-γ-AlO) to enhance the catalytic activity and selectivity toward 1,2-DCE degradation. The Ru SACs/m-γ-AlO shows low and (the temperature for 50 and 90% conversion) of 215 and 289 °C, which are lower than those for Ru NPs/m-γ-AlO (291 and 374 °C) and pristine m-γ-AlO (323 and 386 °C). The degradation products are mainly CO (>94%) and HCl (>90%) by using the Ru SACs/m-γ-AlO catalyst, and almost no byproducts are detected. Furthermore, Ru SACs/m-γ-AlO also presents excellent anti-chlorine poisoning effect and water resistance during the stability test. This work may shed light on the development of efficient single-atom catalysts for the degradation of industrial pollutants.
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http://dx.doi.org/10.1021/acsami.1c08471DOI Listing
November 2021

Balanced Enhancements of Synaptic Excitation and Inhibition Underlie Developmental Maturation of Receptive Fields in the Mouse Visual Cortex.

J Neurosci 2021 Oct 29. Epub 2021 Oct 29.

Center for Neural Circuits and Sensory Processing Disorders, Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California

Neurons in the developing visual cortex undergo progressive functional maturation as indicated by the refinement of their visual feature selectivity. However, changes of the synaptic architecture underlying the maturation of spatial visual receptive fields (RFs) remain largely unclear. Here, loose-patch as well as single-unit recordings in layer 4 of mouse primary visual cortex (V1) of both sexes revealed that RF development in a post-eye-opening period is marked by an increased proportion of cortical neurons with spatially defined RFs, together with the increased signal-to-noise ratio (SNR) of spiking responses. By exploring excitatory and inhibitory synaptic RFs with whole-cell voltage clamp recordings, we observed a balanced enhancement of both synaptic excitation and inhibition, and that while the excitatory subfield size remains relatively constant during development, the inhibitory subfield is broadened. This balanced developmental strengthening of excitatory and inhibitory synaptic inputs results in enhanced visual responses and together with a reduction of spontaneous firing rate contributes to the maturation of visual cortical RFs. Visual deprivation by dark rearing impedes the normal strengthening of excitatory inputs but leaves the apparently normal enhancement of inhibition while preventing the broadening of the inhibitory subfield, leading to weakened RF responses and a reduced fraction of neurons exhibiting a clear RF, as compared to normally reared animals. Our data demonstrate that an experience-dependent and coordinated maturation of excitatory and inhibitory circuits underlie the functional development of visual cortical RFs.The organization of synaptic receptive fields (RFs) is a fundamental determinant of feature selectivity functions in the cortex. However, how changes of excitatory and inhibitory synaptic inputs lead to the functional maturation of visual RFs during cortical development remains not well-understood. In layer 4 of mouse primary visual cortex (V1), we show that a coordinated, balanced enhancement of synaptic excitation and inhibition contributes to the developmental maturation of spatially defined visual RFs. Visual deprivation by dark rearing partially interferes this process, resulting in a relatively more dominant inhibitory tone and a reduced fraction of neurons exhibiting clear RFs at the spike level. These data provide an unprecedented understanding of the functional development of visual cortical RFs at the synaptic level.
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http://dx.doi.org/10.1523/JNEUROSCI.0442-21.2021DOI Listing
October 2021

Effectiveness and Safety of Pressure Dressings on Reducing Subdural Effusion After Decompressive Craniectomy.

Neuropsychiatr Dis Treat 2021 14;17:3119-3125. Epub 2021 Oct 14.

Department of Neurosurgery, People's Hospital of Guanghan City, Guanghan City, Sichuan Province, People's Republic of China.

Objective: Decompressive craniectomy as a treatment is often used in the rescue treatment of critically ill patients in neurosurgery; however, there are many complications after this operation. Subdural effusion is a common complication after decompressive craniectomy. Once it occurs, it can cause further problems for the patient. Therefore, the purpose of this study was to explore the safety and effectiveness of pressure dressings for subdural effusion after decompressive craniectomy.

Methods: Patients who underwent decompressive craniectomy in our hospital from January 2016 to January 2021 were included in this study, and all patients were followed up for 6 months or more. After the operation, the patients were divided into two groups according to whether they received a pressure dressing or a traditional dressing. Subdural effusion, cerebrospinal fluid leakage, hydrocephalus and other complications were compared between the two groups, and the differences in hospital duration, cost and prognosis between the two groups were analyzed.

Results: A total of 123 patients were included in this study. Among them, 62 patients chose pressure dressings, and 61 patients chose traditional dressings. The incidence of subdural effusion in the pressure dressing group was significantly lower than that in the traditional dressing group (P<0.05). There was no difference between the two groups in cerebrospinal fluid leakage and hydrocephalus (P > 0.05). In addition, the length of hospital stay and the total cost in the pressure dressing group were significantly lower (P<0.05).

Conclusion: Pressure dressing can effectively reduce the occurrence of subdural effusion after decompressive craniectomy, and it does not increase the occurrence of other cerebrospinal fluid-related complications.
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http://dx.doi.org/10.2147/NDT.S332653DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8524178PMC
October 2021

Analysis and verification of -methyladenosine-modified genes as novel biomarkers for clear cell renal cell carcinoma.

Bioengineered 2021 Oct 26. Epub 2021 Oct 26.

CAS Key Laboratory of Bio-medical Diagnostics, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences , Suzhou 215163, China.

-methyladenosine (mA) has been involved in diverse biological processes in cancer, but its function and clinical value in clear cell renal cell carcinoma (ccRCC) remain largely unknown. In this study, we found that 1453 mA-modified differentially expressed genes (DEGs) of ccRCC were mainly enriched in cell cycle, PI3K-AKT, and p53 signaling pathways. Then we constructed a co-expression network of the 1453 mA-modified DEGs and identified a most clinically relevant module, where NUF2, CDCA3, CKAP2L, KIF14, and ASPM were hub genes. NUF2, CDCA3, and KIF14 could combine with a major RNA mA methyltransferase METTL14, serving as biomarkers for ccRCC. Real-time quantitative PCR assay confirmed that NUF2, CDCA3, and KIF14 were highly expressed in ccRCC cell lines and ccRCC tissues. Furthermore, these three genes were modified by mA and negatively regulated by METTL14. This study revealed that NUF2, CDCA3, and KIF14 were mA-modified biomarkers, representing a potential diagnostic, prognostic, and therapeutic target for ccRCC.
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http://dx.doi.org/10.1080/21655979.2021.1995574DOI Listing
October 2021

Comparison of metabolic fate, target organs, and microbiota interactions of free and bound dietary advanced glycation end products.

Crit Rev Food Sci Nutr 2021 Oct 26:1-22. Epub 2021 Oct 26.

College of Food Science and Engineering, Northwest A&F University, Yangling, China.

Increased intake of Western diets and ultra-processed foods is accompanied by increased intake of advanced glycation end products (AGEs). AGEs can be generated exogenously in the thermal processing of food and endogenously in the human body, which associated with various chronic diseases. In food, AGEs can be divided into free and bound forms, which differ in their bioavailability, digestion, absorption, gut microbial interactions and untargeted metabolites. We summarized the measurements and contents of free and bound AGE in foods. Moreover, the ingestion, digestion, absorption, excretion, gut microbiota interactions, and metabolites and metabolic pathways between free and bound AGEs based on animal and human studies were compared. Bound AGEs were predominant in most of the selected foods, while beer and soy sauce were rich in free AGEs. Only 10%-30% of AGEs were absorbed into the systemic circulation when orally administered. The excretion of ingested free and bound AGEs was approximately 90% and 60%, respectively. Dietary free CML has a detrimental effect on gut microbiota composition, while bound AGEs have both detrimental and beneficial impacts. Free and bound dietary AGEs changed amino acid metabolism, energy metabolism and carbohydrate metabolism. And besides, bound dietary AGEs altered vitamin metabolism, and glycerolipid metabolism.
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http://dx.doi.org/10.1080/10408398.2021.1991265DOI Listing
October 2021

Reactive Flame Retardants: Are They Safer Replacements?

Environ Sci Technol 2021 11 19;55(21):14477-14479. Epub 2021 Oct 19.

School of Civil and Environmental Engineering, Nanyang Technological University, Singapore 639798.

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http://dx.doi.org/10.1021/acs.est.1c06355DOI Listing
November 2021

Progress on the Physiological Function of Mitochondrial DNA and Its Specific Detection and Therapy.

Chembiochem 2021 Oct 18. Epub 2021 Oct 18.

Key Laboratory of Flexible Electronics (KLOFE) and, Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing Tech University (Nanjing Tech), 30 South Puzhu Road, Nanjing, 211816, P. R. China.

Mitochondrial DNA (mtDNA) is the genetic information of mitochondrion, and its structure is circular double-stranded. Despite the diminutive size of the mitochondrial genome, mtDNA mutations are an important cause of mitochondrial diseases which are characterized by defects in oxidative phosphorylation (OXPHOS). Mitochondrial diseases are involved in multiple systems, particularly in the organs that are highly dependent on aerobic metabolism. The diagnosis of mitochondrial disease is more complicated since mtDNA mutations can cause various clinical symptoms. To realize more accurate diagnosis and treatment of mitochondrial diseases, the detection of mtDNA and the design of drugs acting on it are extremely important. Over the past few years, many probes and therapeutic drugs targeting mtDNA have been developed, making significant contributions to fundamental research including elucidation of the mechanisms of mitochondrial diseases at the genetic level. In this review, we summarize the structure, function, and detection approaches for mtDNA. The most current topics in this field, such as mechanistic exploration and treatment of mtDNA mutation-related disorders, are also reviewed. Specific attention is given to discussing the design and development of these probes and drugs for mtDNA. We hope that this review will provide readers with a comprehensive understanding of the importance of mtDNA, and promote the development of effective molecules for theragnosis of mtDNA mutation-related diseases.
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http://dx.doi.org/10.1002/cbic.202100474DOI Listing
October 2021

Assessment of TMB, PD-L1, and lymphocyte to monocyte ratio as predictive potential in a phase Ib study of sintilimab in patients with advanced solid tumors.

Am J Cancer Res 2021 15;11(9):4259-4276. Epub 2021 Sep 15.

The First Affiliated Hospital, Zhejiang University School of Medicine Hangzhou, Zhejiang, China.

Background: Sintilimab is a humanized monoclonal antibody against the programmed cell death 1 (PD-L1). We aimed to assess the safety and activity of sintilimab monotherapy or in combination with chemotherapy in advanced solid tumors.

Methods: This phase Ib study included six cohorts. Cohort A-C were sintilimab monotherapy settings, and enrolled pretreated patients (2/3 L cohorts). Cohort D-F were treatment-naïve patients (1 L cohorts), and received sintilimab plus different chemotherapies. The primary endpoints were safety and objective response rate (ORR). Exploratory endpoints were potential biomarkers for the prognosis after treatment, such as tumor mutation burden scores (TMB), PD-L1 and lymphocyte-to-monocyte ratio (LMR).

Results: The ORR was 14.6% in the 2/3 L cohorts (n=146), and 73.2% in the 1 L cohorts (n=61). The incidence of grade 3-4 adverse events occurred in 55 patients (37.7%) in 2/3 L cohorts, and in 38 (62.3%) in 1 L cohorts. 157 patients had available TMB scores, and in 2/3 L cohorts, patients in the high TMB groups (TMB≥10) showed a longer progression-free survival (PFS) and overall survival (OS) than those in the low TMB groups (TMB<10). No significant differences in PFS and OS were observed across different PD-L1 groups in both 1 L and 2/3 L cohorts. A high LMR was significantly associated with an improved PFS in 1 L cohorts (P=0.022).

Conclusion: Sintilimab alone or combined with chemotherapy had a tolerable safety profile in solid tumors. The combination therapy showed a favorable activity with advanced non-small cell lung cancer and gastric or esophagogastric junction adenocarcinoma. LMR might be a prognostic factor for the combination regimen in these patients.

Trial Registration: ClinicalTrials.gov, number NCT02937116. Registered 18 October 2016.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8493392PMC
September 2021

Single-Cell Transcriptomic Analysis of Peripheral Blood Reveals a Novel B-Cell Subset in Renal Allograft Recipients With Accommodation.

Front Pharmacol 2021 30;12:706580. Epub 2021 Sep 30.

Transplantation Center, The Third Xiangya Hospital, Central South University, Changsha, China.

Kidney transplantation (KTx) is a preeminent treatment for end-stage renal disease (ESRD). After the application of immunosuppressants (IS), renal allograft recipients could reach a state called accommodation which means they are neither rejected nor infected. This study aimed to describe the details of this immune accommodation and reveal a novel mechanism of IS on immune cell subpopulations. We analyzed multiple cell subgroups and their gene expression of peripheral T, B, myeloid, and NK cells from renal allograft recipients with accommodation and healthy control (HC) by single-cell transcriptomics sequencing (scRNA-seq) and flow cytometry. A total of 8,272 cells were isolated and sequenced from three individuals, including 2,758 cells from HC, 2,550 cells from ESRD patient, and 2,964 cells from KTx patient, as well as 396 immune response-related genes were detected during sequencing. 5 T-cell, 4 NK-cell, 5 myeloid, and 4 B-cell clusters were defined. Among them, a B-cell subset (CD19IGLC3IGKCTCL1ACD127) of renal transplant recipients with accommodation was significantly lower than that of HC and verified by flow cytometry, and this B-cell subset showed an activated potential because of its high expression of CD127. Furthermore, we found that IL32 might be the key cytokine to induce the differentiation of this B-cell cluster. We found a novel B-cell subset (CD19IGLC3IGKCTCL1ACD127) which was inhibited and decreased in renal allograft recipients with accommodation. This study might reveal the effect of commonly used IS in clinical practice on B-cell subsets and related mechanism.
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http://dx.doi.org/10.3389/fphar.2021.706580DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8514638PMC
September 2021

Physical Origin of Dual-Emission of Au-Ag Bimetallic Nanoclusters.

Front Chem 2021 27;9:756993. Epub 2021 Sep 27.

Shanghai Key Laboratory of Green Chemistry and Chemical Processes, College of Chemistry and Molecular Engineering, East China Normal University, Shanghai, China.

On the origin of photoluminescence of noble metal NCs, there are always hot debates: metal-centered quantum-size confinement effect VS ligand-centered surface state mechanism. Herein, we provided solid evidence that structural water molecules (SWs) confined in the nanocavity formed by surface-protective-ligand packing on the metal NCs are the real luminescent emitters of Au-Ag bimetal NCs. The Ag cation mediated Au-Ag bimetal NCs exhibit the unique pH-dependent dual-emission characteristic with larger Stokes shift up to 200 nm, which could be used as potential ratiometric nanosensors for pH detection. Our results provide a completely new insight on the understanding of the origin of photoluminescence of metal NCs, which elucidates the abnormal PL emission phenomena, including solvent effect, pH-dependent behavior, surface ligand effect, multiple emitter centers, and large-Stoke's shift
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http://dx.doi.org/10.3389/fchem.2021.756993DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8503609PMC
September 2021

Topological holographic quench dynamics in a synthetic frequency dimension.

Light Sci Appl 2021 Oct 7;10(1):209. Epub 2021 Oct 7.

State Key Laboratory of Advanced Optical Communication Systems and Networks, School of Physics and Astronomy, Shanghai Jiao Tong University, 200240, Shanghai, China.

The notion of topological phases extended to dynamical systems stimulates extensive studies, of which the characterization of nonequilibrium topological invariants is a central issue and usually necessitates the information of quantum dynamics in both the time and momentum dimensions. Here, we propose the topological holographic quench dynamics in synthetic dimension, and also show it provides a highly efficient scheme to characterize photonic topological phases. A pseudospin model is constructed with ring resonators in a synthetic lattice formed by frequencies of light, and the quench dynamics is induced by initializing a trivial state, which evolves under a topological Hamiltonian. Our key prediction is that the complete topological information of the Hamiltonian is encoded in quench dynamics solely in the time dimension, and is further mapped to lower-dimensional space, manifesting the holographic features of the dynamics. In particular, two fundamental time scales emerge in the dynamical evolution, with one mimicking the topological band on the momentum dimension and the other characterizing the residue time evolution of the state after the quench. For this, a universal duality between the quench dynamics and the equilibrium topological phase of the spin model is obtained in the time dimension by extracting information from the field evolution dynamics in modulated ring systems in simulations. This work also shows that the photonic synthetic frequency dimension provides an efficient and powerful way to explore the topological nonequilibrium dynamics.
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http://dx.doi.org/10.1038/s41377-021-00646-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8497532PMC
October 2021

Combination of Total Psoas Index and Albumin-Globulin Score for the Prognosis Prediction of Bladder Cancer Patients After Radical Cystectomy: A Population-Based Study.

Front Oncol 2021 20;11:724536. Epub 2021 Sep 20.

Department of Urology, Shanghai Shidong Hospital of Yangpu District, Shanghai, China.

Background: Sarcopenia as the loss of skeletal muscle mass is related with poor postoperative survival. This work purposed to evaluate the prognostic prediction of the total psoas index (TPI), albumin-globulin score (AGS), and the combination of TPI and AGS (CTA) in bladder cancer (BCa) patients after radical cystectomy.

Methods: BCa patients that received radical cystectomy between 2012 and 2020 were retrieved from our medical center. The calculation of TPI was based on the plain computed tomography images. The predictive effects of TPI, AGS, and CTA grade on survival of BCa patients were analyzed and compared with the albumin-globulin ratio (AGR) through the receiver operating characteristic (ROC) curves. A nomogram was further established based on the Cox regression results from CTA grade and clinicopathological characteristics, which are verified by the decision curve analysis (DCA).

Results: A total of 112 eligible patients diagnosed as BCa were included in this study for retrospective analysis. The patients with lower TPI or higher AGS grade (1/2) contained poorer overall survival (OS) and disease-free survival (DFS). Divided by CTA grade, there were 35 (31.25%) patients in grade 1 associated with the best postoperative prognosis, which was accompanied with increased TPI and decreased AGS. The CTA grade could better predict postoperative outcomes compared with TPI, AGR, and AGS for the highest area under the curve (AUC; 0.674 of OS and 0.681 of DFS). The 3- and 5-year OS and DFS nomograms were conducted based on CTA grade and clinical variables, with a higher predictive performance than the TNM stage.

Conclusion: This study revealed that the novel index CTA functioned as an effective prognostic predictor for postoperative OS and DFS of BCa patients after radical cystectomy. Preoperative assessment of CTA would contribute to optimizing clinical therapies.
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http://dx.doi.org/10.3389/fonc.2021.724536DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8488353PMC
September 2021

The mouse cortico-basal ganglia-thalamic network.

Nature 2021 10 6;598(7879):188-194. Epub 2021 Oct 6.

Mark and Mary Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

The cortico-basal ganglia-thalamo-cortical loop is one of the fundamental network motifs in the brain. Revealing its structural and functional organization is critical to understanding cognition, sensorimotor behaviour, and the natural history of many neurological and neuropsychiatric disorders. Classically, this network is conceptualized to contain three information channels: motor, limbic and associative. Yet this three-channel view cannot explain the myriad functions of the basal ganglia. We previously subdivided the dorsal striatum into 29 functional domains on the basis of the topography of inputs from the entire cortex. Here we map the multi-synaptic output pathways of these striatal domains through the globus pallidus external part (GPe), substantia nigra reticular part (SNr), thalamic nuclei and cortex. Accordingly, we identify 14 SNr and 36 GPe domains and a direct cortico-SNr projection. The striatonigral direct pathway displays a greater convergence of striatal inputs than the more parallel striatopallidal indirect pathway, although direct and indirect pathways originating from the same striatal domain ultimately converge onto the same postsynaptic SNr neurons. Following the SNr outputs, we delineate six domains in the parafascicular and ventromedial thalamic nuclei. Subsequently, we identify six parallel cortico-basal ganglia-thalamic subnetworks that sequentially transduce specific subsets of cortical information through every elemental node of the cortico-basal ganglia-thalamic loop. Thalamic domains relay this output back to the originating corticostriatal neurons of each subnetwork in a bona fide closed loop.
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http://dx.doi.org/10.1038/s41586-021-03993-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8494639PMC
October 2021

Elucidating the Cooperative Roles of Water and Lewis Acid-Base Pairs in Cascade C-C Coupling and Self-Deoxygenation Reactions.

JACS Au 2021 Sep 17;1(9):1471-1487. Epub 2021 Aug 17.

The Gene & Linda Voiland School of Chemical Engineering and Bioengineering, Washington State University, Pullman, Washington 99164, United States.

Water plays pivotal roles in tailoring reaction pathways in many important reactions, including cascade C-C bond formation and oxygen elimination. Herein, a kinetic study combined with complementary analyses (DRIFTS, isotopic study, H solid-state magic angle spinning nuclear magnetic resonance) and density functional theory (DFT) calculations are performed to elucidate the roles of water in cascade acetone-to-isobutene reactions on a Zn Zr O mixed metal oxide with balanced Lewis acid-base pairs. Our results reveal that the reaction follows the acetone-diacetone alcohol-isobutene pathway. Isobutene is produced through an intramolecular rearrangement of the eight-membered ring intermediate formed via the adsorption of diacetone alcohol on the Lewis acid-base pairs in the presence of cofed water. OH adspecies, formed by the dissociative adsorption of water on the catalyst surface, were found to distort diacetone alcohol's hydroxyl functional group toward its carbonyl functional group and facilitate the intramolecular rearrangement of diacetone alcohol to form isobutene. In the absence of water, diacetone alcohol binds strongly to the Lewis acid site, e.g., at a Zr site, via its carbonyl functional group, leading to its dramatic structural distortion and further dehydration reaction to form mesityl oxide as well as subsequent polymerization reactions and the formation of coke. The present results provide insights into the cooperative roles of water and Lewis acid-base pairs in catalytic upgrading of biomass to fuels and chemicals.
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http://dx.doi.org/10.1021/jacsau.1c00218DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8479772PMC
September 2021
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