Publications by authors named "Blossom Damania"

99Publications

Streptavidin Promotes DNA Binding and Activation of cGAS to Enhance Innate Immunity.

iScience 2020 Aug 14;23(9):101463. Epub 2020 Aug 14.

Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Biochemistry and Biophysics, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.isci.2020.101463DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7476851PMC
August 2020

Modeling oncogenic herpesvirus infections in humanized mice.

Curr Opin Virol 2020 Aug 9;44:90-96. Epub 2020 Aug 9.

Department of Microbiology and Immunology and Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United States. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.coviro.2020.07.005DOI Listing
August 2020

PPP6C Negatively Regulates STING-Dependent Innate Immune Responses.

mBio 2020 08 4;11(4). Epub 2020 Aug 4.

Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/mBio.01728-20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7407089PMC
August 2020

Mdm2-mediated neddylation of pVHL blocks the induction of antiangiogenic factors.

Oncogene 2020 Jul 17;39(29):5228-5239. Epub 2020 Jun 17.

Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41388-020-1359-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7368819PMC
July 2020

ADAR1 Facilitates KSHV Lytic Reactivation by Modulating the RLR-Dependent Signaling Pathway.

Cell Rep 2020 Apr;31(4):107564

Department of Microbiology and Immunology, Lineberger Comprehensive Cancer Center, and Center for AIDS Research, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2020.107564DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319254PMC
April 2020

KSHV: Immune Modulation and Immunotherapy.

Front Immunol 2019 7;10:3084. Epub 2020 Feb 7.

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fimmu.2019.03084DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7025529PMC
February 2020

Endosomal TLR-8 Senses microRNA-1294 Resulting in the Production of NFḱB Dependent Cytokines.

Front Immunol 2019 6;10:2860. Epub 2019 Dec 6.

Department of Endodontics, Dental School, University of Texas Health Science Center at San Antonio, San Antonio, TX, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fimmu.2019.02860DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6909240PMC
December 2019

Kaposi's Sarcoma-Associated Herpesvirus Viral Interleukin-6 Signaling Upregulates Integrin β3 Levels and Is Dependent on STAT3.

J Virol 2020 02 14;94(5). Epub 2020 Feb 14.

Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/JVI.01384-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7022358PMC
February 2020

Kaposi Sarcoma-Associated Herpesvirus (KSHV).

Trends Microbiol 2020 Mar 20;28(3):236-237. Epub 2019 Nov 20.

Department of Microbiology and Immunology and Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.tim.2019.10.006DOI Listing
March 2020

Small molecule screening identifies inhibitors of the Epstein-Barr virus deubiquitinating enzyme, BPLF1.

Antiviral Res 2020 01 8;173:104649. Epub 2019 Nov 8.

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.antiviral.2019.104649DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7017600PMC
January 2020

Runaway Kaposi Sarcoma-associated herpesvirus replication correlates with systemic IL-10 levels.

Virology 2020 01 2;539:18-25. Epub 2019 Oct 2.

UNC Lineberger Comprehensive Cancer Center and Department of Microbiology and Immunology, School of Medicine, The University of North Carolina at Chapel Hill, 450 West Drive, Chapel Hill, NC, 27599, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.virol.2019.10.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6908428PMC
January 2020

Modulation of Angiogenic Processes by the Human Gammaherpesviruses, Epstein-Barr Virus and Kaposi's Sarcoma-Associated Herpesvirus.

Front Microbiol 2019 12;10:1544. Epub 2019 Jul 12.

Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fmicb.2019.01544DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6640166PMC
July 2019

Kinome profiling of non-Hodgkin lymphoma identifies Tyro3 as a therapeutic target in primary effusion lymphoma.

Proc Natl Acad Sci U S A 2019 08 25;116(33):16541-16550. Epub 2019 Jul 25.

Department of Microbiology and Immunology and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1903991116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6697815PMC
August 2019

Models of Oncoproteins Encoded by Kaposi's Sarcoma-Associated Herpesvirus.

J Virol 2019 06 15;93(11). Epub 2019 May 15.

Department of Microbiology and Immunology and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/JVI.01053-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6532075PMC
June 2019

Targeting mTOR with MLN0128 Overcomes Rapamycin and Chemoresistant Primary Effusion Lymphoma.

mBio 2019 02 19;10(1). Epub 2019 Feb 19.

UNC Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, USA

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/mBio.02871-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381283PMC
February 2019

Extracellular vesicles from Kaposi Sarcoma-associated herpesvirus lymphoma induce long-term endothelial cell reprogramming.

PLoS Pathog 2019 02 4;15(2):e1007536. Epub 2019 Feb 4.

Department of Microbiology and Immunology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.ppat.1007536DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361468PMC
February 2019

Kaposi sarcoma.

Nat Rev Dis Primers 2019 01 31;5(1). Epub 2019 Jan 31.

Leidos Biomedical Research, AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41572-019-0060-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6685213PMC
January 2019

Immunodeficiencies that predispose to pathologies by human oncogenic γ-herpesviruses.

FEMS Microbiol Rev 2019 03;43(2):181-192

Viral Immunobiology, Institute of Experimental Immunology, University of Zürich, 8057 Zürich, Switzerland.

View Article

Download full-text PDF

Source
https://academic.oup.com/femsre/advance-article/doi/10.1093/
Publisher Site
http://dx.doi.org/10.1093/femsre/fuy044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435449PMC
March 2019

Kaposi's Sarcoma-Associated Herpesvirus (KSHV)-Associated Disease in the AIDS Patient: An Update.

Cancer Treat Res 2019;177:63-80

Department of Microbiology & Immunology, Lineberger Comprehensive Cancer Center, University of North Carolina, CB #7295, NC, 27599, Chapel Hill, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-3-030-03502-0_3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201581PMC
June 2019

Large-scale, cross-flow based isolation of highly pure and endocytosis-competent extracellular vesicles.

J Extracell Vesicles 2018 30;7(1):1541396. Epub 2018 Nov 30.

Lineberger Comprehensive Cancer Center and Department of Microbiology and Immunology, The University of North Carolina, Chapel Hill, NC, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/20013078.2018.1541396DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282418PMC
November 2018

Innate Sensing of DNA Virus Genomes.

Annu Rev Virol 2018 09;5(1):341-362

Lineberger Comprehensive Cancer Center and Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA; email:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1146/annurev-virology-092917-043244DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443256PMC
September 2018

Chromatin remodeling controls Kaposi's sarcoma-associated herpesvirus reactivation from latency.

PLoS Pathog 2018 09 13;14(9):e1007267. Epub 2018 Sep 13.

Lineberger Comprehensive Cancer Center, Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.ppat.1007267DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6136816PMC
September 2018

cGAS and STING: At the intersection of DNA and RNA virus-sensing networks.

PLoS Pathog 2018 08 16;14(8):e1007148. Epub 2018 Aug 16.

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.ppat.1007148DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6095619PMC
August 2018

Air-Liquid Interface System To Understand Epstein-Barr Virus-Associated Nasopharyngeal Carcinoma.

mSphere 2018 07 18;3(4). Epub 2018 Jul 18.

Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/mSphere.00350-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6052335PMC
July 2018

RIG-I Detects Kaposi's Sarcoma-Associated Herpesvirus Transcripts in a RNA Polymerase III-Independent Manner.

mBio 2018 07 3;9(4). Epub 2018 Jul 3.

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/mBio.00823-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6030556PMC
July 2018

Nef Secretion into Extracellular Vesicles or Exosomes Is Conserved across Human and Simian Immunodeficiency Viruses.

mBio 2018 02 6;9(1). Epub 2018 Feb 6.

Department of Microbiology and Immunology, Lineberger Comprehensive Cancer Center, School of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/mBio.02344-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5801467PMC
February 2018

Kaposi's Sarcoma-Associated Herpesvirus Increases PD-L1 and Proinflammatory Cytokine Expression in Human Monocytes.

mBio 2017 10 10;8(5). Epub 2017 Oct 10.

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/mBio.00917-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5635685PMC
October 2017

Tumour viruses and innate immunity.

Philos Trans R Soc Lond B Biol Sci 2017 Oct;372(1732)

Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1098/rstb.2016.0267DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5597734PMC
October 2017

NLRX1 negatively modulates type I IFN to facilitate KSHV reactivation from latency.

PLoS Pathog 2017 May 1;13(5):e1006350. Epub 2017 May 1.

Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, United States of America.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.ppat.1006350DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5426799PMC
May 2017

Kaposi's sarcoma in Malawi: a continued problem for HIV-positive and HIV-negative individuals.

AIDS 2017 01;31(2):318-319

aLineberger Comprehensive Cancer Center bDepartment of Microbiology & Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA cUNC Project-Malawi dLighthouse Trust Clinic, Kamuzu Central Hospital, Lilongwe eUniversity of Malawi College of Medicine, Blantyre, Malawi fDepartment of Medicine, Institute for Global Health and Infectious Diseases gGillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/QAD.0000000000001341DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5180456PMC
January 2017

Signal transducer and activator of transcription 3 () regulates host defense and protects mice against herpes simplex virus-1 (HSV-1) infection.

J Leukoc Biol 2017 04 13;101(4):1053-1064. Epub 2016 Dec 13.

Department of Cell Biology and Physiology, University of North Carolina, Chapel Hill, North Carolina, USA;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1189/jlb.4A1016-199RRDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5346178PMC
April 2017

The KSHV K1 Protein Modulates AMPK Function to Enhance Cell Survival.

PLoS Pathog 2016 Nov 9;12(11):e1005985. Epub 2016 Nov 9.

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.ppat.1005985DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5102384PMC
November 2016

Next-Generation High-Throughput Functional Annotation of Microbial Genomes.

mBio 2016 10 4;7(5). Epub 2016 Oct 4.

Department of Immunology and Infectious Disease, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/mBio.01245-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5050336PMC
October 2016

Differential IgM expression distinguishes two types of pediatric Burkitt lymphoma in mouse and human.

Oncotarget 2016 09;7(39):63504-63513

Lineberger Comprehensive Cancer Center, the University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18632/oncotarget.11531DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5325380PMC
September 2016

Metabolic reprogramming through fatty acid transport protein 1 (FATP1) regulates macrophage inflammatory potential and adipose inflammation.

Mol Metab 2016 Jul 23;5(7):506-526. Epub 2016 Apr 23.

Department of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Nutrition, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Nutrition Obesity Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.molmet.2016.04.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4921943PMC
July 2016

A viral kinase mimics S6 kinase to enhance cell proliferation.

Proc Natl Acad Sci U S A 2016 07 24;113(28):7876-81. Epub 2016 Jun 24.

Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1600587113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4948314PMC
July 2016

The K1 Protein of Kaposi's Sarcoma-Associated Herpesvirus Augments Viral Lytic Replication.

J Virol 2016 09 12;90(17):7657-66. Epub 2016 Aug 12.

Lineberger Comprehensive Cancer Center and Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/JVI.03102-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4988170PMC
September 2016

Discovery of a Novel Bat Gammaherpesvirus.

mSphere 2016 Jan-Feb;1(1). Epub 2016 Feb 17.

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/mSphere.00016-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4863598PMC
June 2016

Recent advances in understanding Kaposi's sarcoma-associated herpesvirus.

F1000Res 2016 25;5. Epub 2016 Apr 25.

Lineberger Comprehensive Cancer Center and Department of Microbiology & Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12688/f1000research.7612.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4847565PMC
May 2016

Editorial: NLRP3: immune activator or modulator?

J Leukoc Biol 2016 05;99(5):641-3

Lineberger Comprehensive Cancer Center and Department of Microbiology & Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1189/jlb.3CE0915-443RDOI Listing
May 2016

The cGAS-STING Defense Pathway and Its Counteraction by Viruses.

Cell Host Microbe 2016 Feb;19(2):150-8

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Microbiology & Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.chom.2016.01.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4755325PMC
February 2016

A Virological Perspective on Cancer.

Authors:
Blossom Damania

PLoS Pathog 2016 Feb 11;12(2):e1005326. Epub 2016 Feb 11.

Lineberger Comprehensive Cancer Center and Department of Microbiology & Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.ppat.1005326DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4750867PMC
February 2016

Kaposi's Sarcoma-Associated Herpesvirus Interleukin-6 Modulates Endothelial Cell Movement by Upregulating Cellular Genes Involved in Migration.

mBio 2015 Dec 8;6(6):e01499-15. Epub 2015 Dec 8.

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/mBio.01499-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4676281PMC
December 2015

Animal models of tumorigenic herpesviruses--an update.

Curr Opin Virol 2015 Oct;14:145-50

Lineberger Comprehensive Cancer Center, Department of Microbiology and Immunology, Center for AIDS Research (CfAR), School of Medicine, University of North Carolina, Chapel Hill, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.coviro.2015.09.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4628858PMC
October 2015

Editorial overview: Viruses and cancer.

Curr Opin Virol 2015 Oct 29;14:viii-x. Epub 2015 Sep 29.

The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.coviro.2015.09.002DOI Listing
October 2015

Kaposi's Sarcoma-Associated Herpesvirus Viral Interferon Regulatory Factor 1 Interacts with a Member of the Interferon-Stimulated Gene 15 Pathway.

J Virol 2015 Nov 9;89(22):11572-83. Epub 2015 Sep 9.

Lineberger Comprehensive Cancer Center and Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/JVI.01482-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4645652PMC
November 2015

Modulation of the cGAS-STING DNA sensing pathway by gammaherpesviruses.

Proc Natl Acad Sci U S A 2015 Aug 21;112(31):E4306-15. Epub 2015 Jul 21.

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599; University of North Carolina Center for AIDS Research, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1503831112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4534226PMC
August 2015

Immune cell-based screening assay for response to anticancer agents: applications in pharmacogenomics.

Pharmgenomics Pers Med 2015 26;8:81-98. Epub 2015 Feb 26.

Division of Pharmacotherapy and Experimental Therapeutics, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, USA ; Lineberger Comprehensive Cancer Center, School of Medicine, University of North Carolina, Chapel Hill, NC, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/PGPM.S73312DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4397719PMC
April 2015

FOXP1 potentiates Wnt/β-catenin signaling in diffuse large B cell lymphoma.

Sci Signal 2015 Feb 3;8(362):ra12. Epub 2015 Feb 3.

Department of Cell Biology and Physiology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7295, USA. Division of Microbiology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, NC 27516-7361, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/scisignal.2005654DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4356208PMC
February 2015

Toll-like receptor-3 is dispensable for the innate microRNA response to West Nile virus (WNV).

PLoS One 2014 15;9(8):e104770. Epub 2014 Aug 15.

Department of Microbiology and Immunology, Lineberger Comprehensive Cancer Center, Center for AIDS Research, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0104770PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4134228PMC
February 2016

What lies within: coinfections and immunity.

Cell Host Microbe 2014 Aug;16(2):145-147

Department of Microbiology and Immunology, Program in Global Oncology at the Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7295, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.chom.2014.07.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4135381PMC
August 2014

Modulation of Kaposi's sarcoma-associated herpesvirus interleukin-6 function by hypoxia-upregulated protein 1.

J Virol 2014 Aug 11;88(16):9429-41. Epub 2014 Jun 11.

Lineberger Comprehensive Cancer Center and Department of Microbiology & Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/JVI.00511-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4136275PMC
August 2014

An important role for mitochondrial antiviral signaling protein in the Kaposi's sarcoma-associated herpesvirus life cycle.

J Virol 2014 May 12;88(10):5778-87. Epub 2014 Mar 12.

Lineberger Comprehensive Cancer Center, Program in Global Oncology, and Department of Microbiology & Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/JVI.03226-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4019080PMC
May 2014

NLRC3, a member of the NLR family of proteins, is a negative regulator of innate immune signaling induced by the DNA sensor STING.

Immunity 2014 Mar 20;40(3):329-41. Epub 2014 Feb 20.

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Institute of Inflammatory Diseases and Center for Translational Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.immuni.2014.01.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4011014PMC
March 2014

KSHV: pathways to tumorigenesis and persistent infection.

Adv Virus Res 2014 ;88:111-59

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/B978-0-12-800098-4.00002-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4104069PMC
August 2014

KSHV LANA and EBV LMP1 induce the expression of UCH-L1 following viral transformation.

Virology 2014 Jan 8;448:293-302. Epub 2013 Nov 8.

Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.virol.2013.10.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4157526PMC
January 2014

The open chromatin landscape of Kaposi's sarcoma-associated herpesvirus.

J Virol 2013 Nov 28;87(21):11831-42. Epub 2013 Aug 28.

Lineberger Comprehensive Cancer Center.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/JVI.01685-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3807352PMC
November 2013

Systemically circulating viral and tumor-derived microRNAs in KSHV-associated malignancies.

PLoS Pathog 2013 18;9(7):e1003484. Epub 2013 Jul 18.

Lineberger Comprehensive Cancer Center, Program in Global Oncology, Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.ppat.1003484DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3715412PMC
February 2014

Modulation of B-cell exosome proteins by gamma herpesvirus infection.

Proc Natl Acad Sci U S A 2013 Jul 1;110(31):E2925-33. Epub 2013 Jul 1.

Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1303906110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3732930PMC
July 2013

Kaposi sarcoma associated herpesvirus pathogenesis (KSHV)--an update.

Curr Opin Virol 2013 Jun 13;3(3):238-44. Epub 2013 Jun 13.

Lineberger Comprehensive Cancer Center and Department of Microbiology & Immunology, Program in Global Oncology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.coviro.2013.05.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3716290PMC
June 2013

Recent cancer incidence trends in an observational clinical cohort of HIV-infected patients in the US, 2000 to 2011.

Infect Agent Cancer 2013 May 24;8(1):18. Epub 2013 May 24.

Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, 715 Mary Ellen Jones Building, Chapel Hill, NC, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/1750-9378-8-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3671969PMC
May 2013

Tousled-like kinases modulate reactivation of gammaherpesviruses from latency.

Cell Host Microbe 2013 Feb;13(2):204-14

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S19313128130003
Publisher Site
http://dx.doi.org/10.1016/j.chom.2012.12.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3602413PMC
February 2013

AKTivation of PI3K/AKT/mTOR signaling pathway by KSHV.

Front Immunol 2012 7;3:401. Epub 2013 Jan 7.

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill Chapel Hill, NC, USA ; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill Chapel Hill, NC, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fimmu.2012.00401DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3539662PMC
January 2013

Hsp90 inhibitors are efficacious against Kaposi Sarcoma by enhancing the degradation of the essential viral gene LANA, of the viral co-receptor EphA2 as well as other client proteins.

PLoS Pathog 2012 29;8(11):e1003048. Epub 2012 Nov 29.

Department of Microbiology and Immunology, Program in Global Oncology, Lineberger Comprehensive Cancer Center, Center for AIDS Research, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.ppat.1003048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3510261PMC
April 2013

The viral interferon regulatory factors of kaposi's sarcoma-associated herpesvirus differ in their inhibition of interferon activation mediated by toll-like receptor 3.

J Virol 2013 Jan 31;87(2):798-806. Epub 2012 Oct 31.

Lineberger Comprehensive Cancer Center and Department of Microbiology & Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/JVI.01851-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3554052PMC
January 2013

Toll-like receptor sensing of human herpesvirus infection.

Front Cell Infect Microbiol 2012 8;2:122. Epub 2012 Oct 8.

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill Chapel Hill, NC, USA; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill Chapel Hill, NC, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fcimb.2012.00122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3465860PMC
December 2013

Vironome of Kaposi sarcoma associated herpesvirus-inflammatory cytokine syndrome in an AIDS patient reveals co-infection of human herpesvirus 8 and human herpesvirus 6A.

Virology 2012 Nov 24;433(1):220-5. Epub 2012 Aug 24.

Department of Microbiology and Immunology, Lineberger Comprehensive Cancer Center, Center for AIDS Research, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7290, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.virol.2012.08.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3505605PMC
November 2012

Innate barriers to viral infection.

Future Microbiol 2012 Jul;7(7):815-22

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, NC 27599, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/fmb.12.52DOI Listing
July 2012

Dysregulation of fatty acid synthesis and glycolysis in non-Hodgkin lymphoma.

Proc Natl Acad Sci U S A 2012 Jul 29;109(29):11818-23. Epub 2012 Jun 29.

Lineberger Comprehensive Cancer Center, Department of Microbiology and Immunology, School of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA.

View Article

Download full-text PDF

Source
http://www.pnas.org/cgi/doi/10.1073/pnas.1205995109
Publisher Site
http://dx.doi.org/10.1073/pnas.1205995109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3406848PMC
July 2012

NLRs, inflammasomes, and viral infection.

J Leukoc Biol 2012 Sep 10;92(3):469-77. Epub 2012 May 10.

Lineberger Comprehensive Cancer Center and Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1189/jlb.0312132DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4046246PMC
September 2012

Treatment of Kaposi sarcoma-associated herpesvirus-associated cancers.

Front Microbiol 2012 18;3:141. Epub 2012 Apr 18.

Program in Global Oncology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill Chapel Hill, NC, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fmicb.2012.00141DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3328849PMC
June 2012

Latent Kaposi's sarcoma-associated herpesvirus infection of monocytes downregulates expression of adaptive immune response costimulatory receptors and proinflammatory cytokines.

J Virol 2012 Apr 25;86(7):3916-23. Epub 2012 Jan 25.

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/JVI.06437-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3302530PMC
April 2012

Rapalogs in viral cancers.

Expert Opin Investig Drugs 2012 Feb 4;21(2):135-8. Epub 2012 Jan 4.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1517/13543784.2012.642369DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4160301PMC
February 2012

Inhibition of the inflammasome response by a viral protein that interacts with NLRs.

Commun Integr Biol 2011 Jul 1;4(4):416-8. Epub 2011 Jul 1.

Lineberger Comprehensive Cancer Center and Department of Microbiology & Immunology; University of North Carolina; Chapel Hill, NC USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4161/cib.4.4.15252DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3181509PMC
July 2011

Latent KSHV infection increases the vascular permeability of human endothelial cells.

Blood 2011 Nov 31;118(19):5344-54. Epub 2011 Aug 31.

Department of Cell and Developmental Biology, University of North Carolina at Chapel Hill, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2011-03-341552DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3217415PMC
November 2011

Tumor suppressor genes FHIT and WWOX are deleted in primary effusion lymphoma (PEL) cell lines.

Blood 2011 Aug 17;118(7):e32-9. Epub 2011 Jun 17.

Curriculum in Genetics and Molecular Biology, UNC Lineberger Comprehensive Cancer Center, UNC Center for AIDS Research, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7290, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2010-12-323659DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3158728PMC
August 2011

Discovery of a viral NLR homolog that inhibits the inflammasome.

Science 2011 Jan;331(6015):330-4

Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/science.1199478DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3072027PMC
January 2011

The viral interferon regulatory factors of KSHV: immunosuppressors or oncogenes?

Front Immunol 2011 17;2:19. Epub 2011 Jun 17.

Department of Microbiology and Immunology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill Chapel Hill, NC, USA.

View Article

Download full-text PDF

Source
http://journal.frontiersin.org/article/10.3389/fimmu.2011.00
Publisher Site
http://dx.doi.org/10.3389/fimmu.2011.00019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3342017PMC
August 2012

The Kaposi's sarcoma-associated herpesvirus ORF6 DNA binding protein forms long DNA-free helical protein filaments.

J Struct Biol 2011 Apr 31;174(1):37-43. Epub 2010 Oct 31.

Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599-7295, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jsb.2010.10.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3056921PMC
April 2011

Activation of plasmacytoid dendritic cells by Kaposi's sarcoma-associated herpesvirus.

J Virol 2011 Jan 27;85(2):895-904. Epub 2010 Oct 27.

Lineberger Comprehensive Cancer Center and Department of Microbiology & Immunology, University of North Carolina, Chapel Hill, NC 27599, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/JVI.01007-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3020034PMC
January 2011

Use of cidofovir for the treatment of HIV-negative human herpes virus-8-associated primary effusion lymphoma.

Clin Adv Hematol Oncol 2010 May;8(5):372-4

Department of Microbiology and Immunology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3072025PMC
May 2010

Kaposi's sarcoma-associated herpesvirus and innate immunity.

Future Virol 2010 Mar;5(2):185-196

Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA and Department of Microbiology & Immunology, University of North Carolina, Chapel Hill Chapel Hill, NC 27599, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2217/fvl.10.5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2853973PMC
March 2010

Dual inhibition of PI3K and mTOR inhibits autocrine and paracrine proliferative loops in PI3K/Akt/mTOR-addicted lymphomas.

Blood 2010 Jun 18;115(22):4455-63. Epub 2010 Mar 18.

Lineberger Comprehensive Cancer Center and Department of Microbiology & Immunology, University of North Carolina at Chapel Hill, NC 27599, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2009-10-251082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2881502PMC
June 2010

KSHV and the toll of innate immune activation.

Cell Cycle 2009 Oct 20;8(20):3246-7. Epub 2009 Oct 20.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3099192PMC
http://dx.doi.org/10.4161/cc.8.20.9571DOI Listing
October 2009

Kaposi sarcoma-associated herpesvirus (KSHV): molecular biology and oncogenesis.

Cancer Lett 2010 Mar 3;289(2):140-50. Epub 2009 Aug 3.

Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.canlet.2009.07.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4342847PMC
March 2010

Kaposi's sarcoma-associated herpesvirus encodes a viral deubiquitinase.

J Virol 2009 Oct 29;83(19):10224-33. Epub 2009 Jul 29.

Lineberger Comprehensive Cancer Center and Department of Microbiology & Immunology, University of North Carolina, Chapel Hill, Chapel Hill, North Carolina 27599, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/JVI.00589-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2748038PMC
October 2009

Disruption of LANA in rhesus rhadinovirus generates a highly lytic recombinant virus.

J Virol 2009 Oct 8;83(19):9786-802. Epub 2009 Jul 8.

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/JVI.00704-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2748027PMC
October 2009