Blanca E Himes

Blanca E Himes

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Blanca E Himes

Publications by authors named "Blanca E Himes"

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Shared Genetic and Experimental Links between Obesity-Related Traits and Asthma Subtypes in UK Biobank.

J Allergy Clin Immunol 2019 Oct 24. Epub 2019 Oct 24.

Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2019.09.035DOI Listing
October 2019

Airway Smooth Muscle-Specific Transcriptomic Signatures of Glucocorticoid Exposure.

Am J Respir Cell Mol Biol 2019 Jul;61(1):110-120

1 Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Philadelphia, Pennsylvania; and.

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http://dx.doi.org/10.1165/rcmb.2018-0385OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6604213PMC
July 2019

Genome-wide CRISPR screen identifies suppressors of endoplasmic reticulum stress-induced apoptosis.

Proc Natl Acad Sci U S A 2019 Jul 18;116(27):13384-13393. Epub 2019 Jun 18.

Program in Molecular and Integrative Physiological Sciences, Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA 02115;

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http://dx.doi.org/10.1073/pnas.1906275116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6613086PMC
July 2019

Reply to Mahler: Peak Inspiratory Flow Rate: An Emerging Biomarker in Chronic Obstructive Pulmonary Disease.

Am J Respir Crit Care Med 2019 Jun;199(12):1579

2 University of Pennsylvania Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1164/rccm.201902-0432LEDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6580675PMC
June 2019

Preparing next-generation scientists for biomedical big data: artificial intelligence approaches.

Per Med 2019 05 14;16(3):247-257. Epub 2019 Feb 14.

Institute for Biomedical Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.

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http://dx.doi.org/10.2217/pme-2018-0145DOI Listing
May 2019

Facilitating Inclusion of Geocoded Pollution Data into Health Studies.

AMIA Jt Summits Transl Sci Proc 2019 6;2019:553-561. Epub 2019 May 6.

Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6568125PMC
May 2019

Mobile Health and Inhaler-Based Monitoring Devices for Asthma Management.

J Allergy Clin Immunol Pract 2019 Nov - Dec;7(8):2535-2543

Center for Healthcare Research in Pediatrics (CHeRP) and PRecisiOn Medicine Translational Research (PROMoTeR) Center, Department of Population Medicine, Harvard Pilgrim Health Care Institute and Harvard Medical School, Boston, Mass.

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http://dx.doi.org/10.1016/j.jaip.2019.08.034DOI Listing
May 2019

Disease-Specific Integration of Omics Data to Guide Functional Validation of Genetic Associations.

AMIA Annu Symp Proc 2017 16;2017:1589-1596. Epub 2018 Apr 16.

Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Philadelphia, PA, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5977601PMC
April 2019

Large-scale, multiethnic genome-wide association study identifies novel loci contributing to asthma susceptibility in adults.

J Allergy Clin Immunol 2019 Apr 20;143(4):1633-1635. Epub 2018 Dec 20.

Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass; PRecisiOn Medicine Translational Research (PROMoTeR) Center, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Mass. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00916749183277
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http://dx.doi.org/10.1016/j.jaci.2018.11.037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451881PMC
April 2019

Transcriptomic response of primary human airway epithelial cells to flavoring chemicals in electronic cigarettes.

Sci Rep 2019 Feb 1;9(1):1400. Epub 2019 Feb 1.

Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, 02115, Massachusetts, USA.

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http://dx.doi.org/10.1038/s41598-018-37913-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358614PMC
February 2019

Factors associated with exacerbations among adults with asthma according to electronic health record data.

Asthma Res Pract 2019 18;5. Epub 2019 Jan 18.

1Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104 USA.

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http://dx.doi.org/10.1186/s40733-019-0048-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339400PMC
January 2019

Integration of Transcriptomic Data Identifies Global and Cell-Specific Asthma-Related Gene Expression Signatures.

AMIA Annu Symp Proc 2018 5;2018:1338-1347. Epub 2018 Dec 5.

Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Philadelphia, PA, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371257PMC
December 2018

Approaches to Link Geospatially Varying Social, Economic, and Environmental Factors with Electronic Health Record Data to Better Understand Asthma Exacerbations.

AMIA Annu Symp Proc 2018 5;2018:1561-1570. Epub 2018 Dec 5.

Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Philadelphia, PA, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371292PMC
December 2018

A functional splice variant associated with decreased asthma risk abolishes the ability of gasdermin B to induce epithelial cell pyroptosis.

J Allergy Clin Immunol 2018 11 9;142(5):1469-1478.e2. Epub 2018 Jan 9.

Program in Molecular and Integrative Physiological Sciences, Departments of Environmental Health and Genetics & Complex Diseases, Harvard T.H. Chan School of Public Health, Boston, Mass. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2017.11.040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6037620PMC
November 2018

Inclusion of Unstructured Clinical Text Improves Early Prediction of Death or Prolonged ICU Stay.

Crit Care Med 2018 07;46(7):1125-1132

Division of Pulmonary, Allergy, and Critical Care, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.

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http://dx.doi.org/10.1097/CCM.0000000000003148DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6005735PMC
July 2018

Rapamycin-independent IGF2 expression in Tsc2-null mouse embryo fibroblasts and human lymphangioleiomyomatosis cells.

PLoS One 2018 14;13(5):e0197105. Epub 2018 May 14.

Penn Center for Pulmonary Biology and Pulmonary, Allergy and Critical Care Division, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0197105PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5951544PMC
July 2018

TGF-β1 Evokes Human Airway Smooth Muscle Cell Shortening and Hyperresponsiveness via Smad3.

Am J Respir Cell Mol Biol 2018 05;58(5):575-584

2 Rutgers Institute for Translational Medicine and Science, Child Health Institute, Rutgers University, New Brunswick, New Jersey; and.

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http://dx.doi.org/10.1165/rcmb.2017-0247OCDOI Listing
May 2018

Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks.

Authors:
Florence Demenais Patricia Margaritte-Jeannin Kathleen C Barnes William O C Cookson Janine Altmüller Wei Ang R Graham Barr Terri H Beaty Allan B Becker John Beilby Hans Bisgaard Unnur Steina Bjornsdottir Eugene Bleecker Klaus Bønnelykke Dorret I Boomsma Emmanuelle Bouzigon Christopher E Brightling Myriam Brossard Guy G Brusselle Esteban Burchard Kristin M Burkart Andrew Bush Moira Chan-Yeung Kian Fan Chung Alexessander Couto Alves John A Curtin Adnan Custovic Denise Daley Johan C de Jongste Blanca E Del-Rio-Navarro Kathleen M Donohue Liesbeth Duijts Celeste Eng Johan G Eriksson Martin Farrall Yuliya Fedorova Bjarke Feenstra Manuel A Ferreira Maxim B Freidin Zofia Gajdos Jim Gauderman Ulrike Gehring Frank Geller Jon Genuneit Sina A Gharib Frank Gilliland Raquel Granell Penelope E Graves Daniel F Gudbjartsson Tari Haahtela Susan R Heckbert Dick Heederik Joachim Heinrich Markku Heliövaara John Henderson Blanca E Himes Hiroshi Hirose Joel N Hirschhorn Albert Hofman Patrick Holt Jouke Hottenga Thomas J Hudson Jennie Hui Medea Imboden Vladimir Ivanov Vincent W V Jaddoe Alan James Christer Janson Marjo-Riitta Jarvelin Deborah Jarvis Graham Jones Ingileif Jonsdottir Pekka Jousilahti Michael Kabesch Mika Kähönen David B Kantor Alexandra S Karunas Elza Khusnutdinova Gerard H Koppelman Anita L Kozyrskyj Eskil Kreiner Michiaki Kubo Rajesh Kumar Ashish Kumar Mikko Kuokkanen Lies Lahousse Tarja Laitinen Catherine Laprise Mark Lathrop Susanne Lau Young-Ae Lee Terho Lehtimäki Sébastien Letort Albert M Levin Guo Li Liming Liang Laura R Loehr Stephanie J London Daan W Loth Ani Manichaikul Ingo Marenholz Fernando J Martinez Melanie C Matheson Rasika A Mathias Kenji Matsumoto Hamdi Mbarek Wendy L McArdle Mads Melbye Erik Melén Deborah Meyers Sven Michel Hamida Mohamdi Arthur W Musk Rachel A Myers Maartje A E Nieuwenhuis Emiko Noguchi George T O'Connor Ludmila M Ogorodova Cameron D Palmer Aarno Palotie Julie E Park Craig E Pennell Göran Pershagen Alexey Polonikov Dirkje S Postma Nicole Probst-Hensch Valery P Puzyrev Benjamin A Raby Olli T Raitakari Adaikalavan Ramasamy Stephen S Rich Colin F Robertson Isabelle Romieu Muhammad T Salam Veikko Salomaa Vivi Schlünssen Robert Scott Polina A Selivanova Torben Sigsgaard Angela Simpson Valérie Siroux Lewis J Smith Maria Solodilova Marie Standl Kari Stefansson David P Strachan Bruno H Stricker Atsushi Takahashi Philip J Thompson Gudmar Thorleifsson Unnur Thorsteinsdottir Carla M T Tiesler Dara G Torgerson Tatsuhiko Tsunoda André G Uitterlinden Ralf J P van der Valk Amaury Vaysse Sailaja Vedantam Andrea von Berg Erika von Mutius Judith M Vonk Johannes Waage Nick J Wareham Scott T Weiss Wendy B White Magnus Wickman Elisabeth Widén Gonneke Willemsen L Keoki Williams Inge M Wouters James J Yang Jing Hua Zhao Miriam F Moffatt Carole Ober Dan L Nicolae

Nat Genet 2018 01 22;50(1):42-53. Epub 2017 Dec 22.

Departments of Statistics, Human Genetics and Medicine, Section of Genetic Medicine, University of Chicago, Chicago, IL, USA.

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http://www.nature.com/articles/s41588-017-0014-7
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http://dx.doi.org/10.1038/s41588-017-0014-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5901974PMC
January 2018

Integrated Stress Response Mediates Epithelial Injury in Mechanical Ventilation.

Am J Respir Cell Mol Biol 2017 08;57(2):193-203

3 Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1165/rcmb.2016-0404OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5576586PMC
August 2017

Using omics approaches to understand pulmonary diseases.

Respir Res 2017 08 3;18(1):149. Epub 2017 Aug 3.

Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, 402 Blockley Hall 423 Guardian Drive, Philadelphia, PA, 19104, USA.

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http://dx.doi.org/10.1186/s12931-017-0631-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5543452PMC
August 2017

Enhancing Electronic Health Record Data with Geospatial Information.

AMIA Jt Summits Transl Sci Proc 2017 26;2017:123-132. Epub 2017 Jul 26.

Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5543367PMC
July 2017

Making progress toward understanding the genetic architecture of asthma in the most affected US ethnic group.

Eur Respir J 2017 05 1;49(5). Epub 2017 May 1.

Center for Genomics and Personalized Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA.

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http://dx.doi.org/10.1183/13993003.00329-2017DOI Listing
May 2017

Gender-specific determinants of asthma among U.S. adults.

Asthma Res Pract 2017 24;3. Epub 2017 Jan 24.

Department of Biostatistics and Epidemiology, University of Pennsylvania, 219 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104 USA.

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http://dx.doi.org/10.1186/s40733-017-0030-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5259982PMC
January 2017

Inhibition of PI3K promotes dilation of human small airways in a rho kinase-dependent manner.

Br J Pharmacol 2016 09 3;173(18):2726-38. Epub 2016 Aug 3.

Rutgers Institute for Translational Medicine and Science, Child Health Institute, Rutgers University, New Brunswick, NJ, USA.

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http://dx.doi.org/10.1111/bph.13542DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4995285PMC
September 2016

Vitamin D Modulates Expression of the Airway Smooth Muscle Transcriptome in Fatal Asthma.

PLoS One 2015 24;10(7):e0134057. Epub 2015 Jul 24.

Partners Personalized Medicine, Boston, MA, United States of America; Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0134057PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4514847PMC
May 2016

Innovations in health information technologies for chronic pulmonary diseases.

Respir Res 2016 Apr 5;17:38. Epub 2016 Apr 5.

Computational Health Informatics Program, Boston Children's Hospital, Boston, MA, 02115, USA.

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http://dx.doi.org/10.1186/s12931-016-0354-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4822326PMC
April 2016

Mobile health applications for asthma.

J Allergy Clin Immunol Pract 2015 May-Jun;3(3):446-8.e1-16. Epub 2015 Feb 25.

Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, Pa.

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http://dx.doi.org/10.1016/j.jaip.2014.12.011DOI Listing
February 2016

RNA-Seq transcriptome profiling identifies CRISPLD2 as a glucocorticoid responsive gene that modulates cytokine function in airway smooth muscle cells.

PLoS One 2014 13;9(6):e99625. Epub 2014 Jun 13.

Program in Molecular and Integrative Physiological Sciences, Departments of Environmental Health, and Genetics and Complex Diseases, Harvard School of Public Health, Boston, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0099625PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4057123PMC
October 2015

Inhaled corticosteroid treatment modulates ZNF432 gene variant's effect on bronchodilator response in asthmatics.

J Allergy Clin Immunol 2014 Mar 23;133(3):723-8.e3. Epub 2013 Nov 23.

Harvard Medical School, Boston, Mass; Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Boston, Mass; Center for Genomic Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Mass.

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http://dx.doi.org/10.1016/j.jaci.2013.09.037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3943570PMC
March 2014

Polygenic heritability estimates in pharmacogenetics: focus on asthma and related phenotypes.

Pharmacogenet Genomics 2013 Jun;23(6):324-8

Department of Medicine, Channing Division of Network Medicine, Brigham and Women’s Hospital, 181 Longwood Ave, Boston, MA 02115, USA.

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http://dx.doi.org/10.1097/FPC.0b013e3283607acfDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3767309PMC
June 2013

Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations.

Nat Genet 2011 Jul 31;43(9):887-92. Epub 2011 Jul 31.

Department of Human Genetics, University of Chicago, Chicago, Illinois, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3445408PMC
http://dx.doi.org/10.1038/ng.888DOI Listing
July 2011

Genome Wide Association Study to predict severe asthma exacerbations in children using random forests classifiers.

BMC Med Genet 2011 Jun 30;12:90. Epub 2011 Jun 30.

Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1186/1471-2350-12-90DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3148549PMC
June 2011

The CD4+ T-cell transcriptome and serum IgE in asthma: IL17RB and the role of sex.

BMC Pulm Med 2011 Apr 7;11:17. Epub 2011 Apr 7.

Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1186/1471-2466-11-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3080837PMC
April 2011

Analyses of shared genetic factors between asthma and obesity in children.

J Allergy Clin Immunol 2010 Sep;126(3):631-7.e1-8

Channing Laboratory, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass 02115, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S00916749100103
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http://dx.doi.org/10.1016/j.jaci.2010.06.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2941152PMC
September 2010

Development of a Pharmacogenetic Predictive Test in asthma: proof of concept.

Pharmacogenet Genomics 2010 Feb;20(2):86-93

Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, 133 Brookline Avenue, 6th Floor, Boston, MA 02215-5301, USA.

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http://dx.doi.org/10.1097/FPC.0b013e32833428d0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3654515PMC
February 2010

Prediction of chronic obstructive pulmonary disease (COPD) in asthma patients using electronic medical records.

J Am Med Inform Assoc 2009 May-Jun;16(3):371-9. Epub 2009 Mar 4.

Channing Laboratory, 181 Longwood Ave, Boston, MA 02115, USA.

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http://dx.doi.org/10.1197/jamia.M2846DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2732240PMC
August 2009

Predictive genomics of cardioembolic stroke.

Stroke 2009 Mar 8;40(3 Suppl):S67-70. Epub 2008 Dec 8.

Harvard-Partners Center for Genetics and Genomics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.

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http://dx.doi.org/10.1161/STROKEAHA.108.533273DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2752697PMC
March 2009

Characterization of patients who suffer asthma exacerbations using data extracted from electronic medical records.

AMIA Annu Symp Proc 2008 Nov 6:308-12. Epub 2008 Nov 6.

Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2655929PMC
November 2008

Angiopoietin-1 promotes cardiac and skeletal myocyte survival through integrins.

Circ Res 2005 Mar 3;96(4):e8-24. Epub 2005 Feb 3.

Division of Vascular Biology, Children's Hospital, Boston, MA 02115, USA.

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http://dx.doi.org/10.1161/01.RES.0000158285.57191.60DOI Listing
March 2005