Blake Pepinsky

Blake Pepinsky

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Blake Pepinsky

Blake Pepinsky

Publications by authors named "Blake Pepinsky"

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Tissue distribution of S-metabolically labeled neublastin (BG00010) in rats.

J Pharm Biomed Anal 2020 Feb 6;184:113154. Epub 2020 Feb 6.

Biogen, Cambridge, MA 02142, United States.

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http://dx.doi.org/10.1016/j.jpba.2020.113154DOI Listing
February 2020

A Prodomain Fragment from the Proteolytic Activation of Growth Differentiation Factor 11 Remains Associated with the Mature Growth Factor and Keeps It Soluble.

Biochemistry 2017 08 3;56(33):4405-4418. Epub 2017 Aug 3.

Department of Biotherapeutics and Medicinal Sciences, Biogen , 115 Broadway, Cambridge, Massachusetts 02142, United States.

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http://dx.doi.org/10.1021/acs.biochem.7b00302DOI Listing
August 2017

Determination of the Disulfide Structure of Murine Meteorin, a Neurotrophic Factor, by LC-MS and Electron Transfer Dissociation-High-Energy Collisional Dissociation Analysis of Proteolytic Fragments.

Anal Chem 2017 04 13;89(7):4021-4030. Epub 2017 Mar 13.

Department of Protein Drug Discovery, Biogen Inc. , 225 Binney Street, Cambridge, Massachusetts 02142, United States.

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http://dx.doi.org/10.1021/acs.analchem.6b04600DOI Listing
April 2017

Most Cleaved Anti-Müllerian Hormone Binds Its Receptor in Human Follicular Fluid but Little Is Competent in Serum.

J Clin Endocrinol Metab 2016 12 13;101(12):4618-4627. Epub 2016 Sep 13.

Université Paris Diderot (A.P., C.R., R.F., J.T., J.C.-T., R.L.C., N.d.C.), Sorbonne Paris Cité, F-75013 Paris, France; Institut National de la Santé et de la Recherche Médicale Unité 1133 (A.P., C.R., R.F., J.T., J.C.-T., R.L.C., N.d.C.), Physiologie de l'Axe Gonadotrope, F-75013 Paris, France; Centre National de la Recherche Scientifique (A.P., C.R., R.F., J.T., J.C.-T., R.L.C., N.d.C.), Unité Mixte de Recherche 8251, Biologie Fonctionnelle et Adaptative, F-75013 Paris, France; Centro de Investigaciones Endocrinológicas "Dr. César Bergadá" (R.R.), Consejo Nacional de Investigaciones Cientificas y Técnicas-FEI, División de Endocrinología, Hospital de Niños R Gutiérrez, C1425EFD Buenos Aires, Argentina; Biogen (P.C., R.B.P.), Cambridge, Massachusetts 02142; and Department of Chemistry (R.L.C.), Boston University, Boston, Massachusetts 02215.

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http://dx.doi.org/10.1210/jc.2016-1742DOI Listing
December 2016

Investigating the Role of Artemin Glycosylation.

Pharm Res 2016 06 23;33(6):1383-98. Epub 2016 Feb 23.

Biogen, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1007/s11095-016-1880-xDOI Listing
June 2016

Artemin promotes functional long-distance axonal regeneration to the brainstem after dorsal root crush.

Proc Natl Acad Sci U S A 2015 May 27;112(19):6170-5. Epub 2015 Apr 27.

Department of Integrated Physiology and Pathobiology, Tufts University School of Medicine, Boston, MA 02111; and

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http://dx.doi.org/10.1073/pnas.1502057112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4434726PMC
May 2015

Constitutive negative regulation in the processing of the anti-Müllerian hormone receptor II.

J Cell Sci 2015 Apr 6;128(7):1352-64. Epub 2015 Feb 6.

Department of Cell Research and Immunology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel-Aviv, Israel 69978

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http://dx.doi.org/10.1242/jcs.160143DOI Listing
April 2015

Inhibition of LINGO-1 promotes functional recovery after experimental spinal cord demyelination.

Exp Neurol 2015 Apr 11;266:68-73. Epub 2015 Feb 11.

Department of Discovery Biology, Biogen Idec Inc., 14 Cambridge Center, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.expneurol.2015.02.006DOI Listing
April 2015

A novel platform for engineering blood-brain barrier-crossing bispecific biologics.

FASEB J 2014 Nov 28;28(11):4764-78. Epub 2014 Jul 28.

Human Health Therapeutics Portfolio, National Research Council of Canada, Ottawa, Ontario, Canada

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http://dx.doi.org/10.1096/fj.14-253369DOI Listing
November 2014

Structure of the LINGO-1-anti-LINGO-1 Li81 antibody complex provides insights into the biology of LINGO-1 and the mechanism of action of the antibody therapy.

J Pharmacol Exp Ther 2014 Jul 22;350(1):110-23. Epub 2014 Apr 22.

Departments of Drug and Molecular Discovery, Biogen Idec, Inc., Cambridge, Massachusetts.

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http://dx.doi.org/10.1124/jpet.113.211771DOI Listing
July 2014

LINGO-1 regulates oligodendrocyte differentiation by inhibiting ErbB2 translocation and activation in lipid rafts.

Mol Cell Neurosci 2014 May 28;60:36-42. Epub 2014 Feb 28.

Biogen Idec Inc., 14 Cambridge Center, Cambridge, MA 02142, United States. Electronic address:

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http://dx.doi.org/10.1016/j.mcn.2014.02.006DOI Listing
May 2014

Antibody humanization by redesign of complementarity-determining region residues proximate to the acceptor framework.

Methods 2014 Jan 28;65(1):68-76. Epub 2013 Jun 28.

Biogen Idec, 12 Cambridge Center, Cambridge, MA 02142, United States. Electronic address:

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http://dx.doi.org/10.1016/j.ymeth.2013.06.024DOI Listing
January 2014

Blocking LINGO-1 as a therapy to promote CNS repair: from concept to the clinic.

CNS Drugs 2013 Jul;27(7):493-503

Department of Discovery Neurobiology, Biogen Idec Inc., 14 Cambridge Center, Cambridge, MA 02142, USA.

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http://dx.doi.org/10.1007/s40263-013-0068-8DOI Listing
July 2013

Sphingosine 1-phosphate receptor modulator fingolimod (FTY720) does not promote remyelination in vivo.

Mol Cell Neurosci 2011 Sep 24;48(1):72-81. Epub 2011 Jun 24.

Biogen Idec Inc, Neuro-Discovery Biology, 14 Cambridge Center, Cambridge, Massachusetts 02142, United States.

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https://linkinghub.elsevier.com/retrieve/pii/S10447431110013
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http://dx.doi.org/10.1016/j.mcn.2011.06.007DOI Listing
September 2011

Oligodendrocyte differentiation and myelination defects in OMgp null mice.

Mol Cell Neurosci 2011 Apr 23;46(4):752-61. Epub 2011 Feb 23.

Biogen Idec Inc, 14 Cambridge Center, Cambridge, MA 02142, USA.

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http://dx.doi.org/10.1016/j.mcn.2011.02.008DOI Listing
April 2011

Production of a PEGylated Fab' of the anti-LINGO-1 Li33 antibody and assessment of its biochemical and functional properties in vitro and in a rat model of remyelination.

Bioconjug Chem 2011 Feb 21;22(2):200-10. Epub 2011 Jan 21.

Department of Drug, Biogen Idec, Inc., 14 Cambridge Center, Cambridge, Massachusetts 02142, United States.

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http://dx.doi.org/10.1021/bc1002746DOI Listing
February 2011

Efficient on-column conversion of IgG1 trisulfide linkages to native disulfides in tandem with Protein A affinity chromatography.

J Chromatogr A 2010 Aug 17;1217(32):5225-32. Epub 2010 Jun 17.

Biogen Idec Inc., Department of Bioprocess Development, 14 Cambridge Center, Cambridge, MA 02142, USA.

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http://dx.doi.org/10.1016/j.chroma.2010.06.029DOI Listing
August 2010

Insect GDNF:TTC fusion protein improves delivery of GDNF to mouse CNS.

Biochem Biophys Res Commun 2009 Dec 21;390(3):947-51. Epub 2009 Oct 21.

Cecil B Day Laboratory for Neuromuscular Research, Department of Neurology, Massachusetts General Hospital, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1016/j.bbrc.2009.10.083DOI Listing
December 2009

IGF-1:tetanus toxin fragment C fusion protein improves delivery of IGF-1 to spinal cord but fails to prolong survival of ALS mice.

Brain Res 2009 Sep 27;1287:1-19. Epub 2009 Jun 27.

Cecil B. Day Laboratory for Neuromuscular Research, Department of Neurology, Massachusetts General Hospital, Building 114, 16th Street, Room 3003, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1016/j.brainres.2009.06.066DOI Listing
September 2009

Recombinant GDNF: tetanus toxin fragment C fusion protein produced from insect cells.

Biochem Biophys Res Commun 2009 Jul 22;385(3):380-4. Epub 2009 May 22.

Cecil B. Day Laboratory for Neuromuscular Research, Department of Neurology, Massachusetts General Hospital, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1016/j.bbrc.2009.05.079DOI Listing
July 2009

Purifying the hedgehog protein and its variants.

Methods Mol Biol 2007 ;397:1-22

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http://dx.doi.org/10.1007/978-1-59745-516-9_1DOI Listing
December 2008

Blocking LINGO-1 function promotes retinal ganglion cell survival following ocular hypertension and optic nerve transection.

Invest Ophthalmol Vis Sci 2008 Mar;49(3):975-85

Department of Anatomy, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong SAR, China.

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http://dx.doi.org/10.1167/iovs.07-1199DOI Listing
March 2008

Inhibition of the leucine-rich repeat protein LINGO-1 enhances survival, structure, and function of dopaminergic neurons in Parkinson's disease models.

Proc Natl Acad Sci U S A 2007 Sep 28;104(36):14430-5. Epub 2007 Aug 28.

Neuroregeneration Laboratories, Udall Parkinson's Disease Center of Excellence, Harvard Medical School and McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA.

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http://dx.doi.org/10.1073/pnas.0700901104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1955463PMC
September 2007

LINGO-1 antagonist promotes functional recovery and axonal sprouting after spinal cord injury.

Mol Cell Neurosci 2006 Nov 29;33(3):311-20. Epub 2006 Sep 29.

Biogen Idec, Inc., 14 Cambridge Center, Cambridge, MA 02142, USA.

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http://dx.doi.org/10.1016/j.mcn.2006.08.003DOI Listing
November 2006

A glial cell line-derived neurotrophic factor (GDNF):tetanus toxin fragment C protein conjugate improves delivery of GDNF to spinal cord motor neurons in mice.

Brain Res 2006 Nov 3;1120(1):1-12. Epub 2006 Oct 3.

Columbia University, Department of Neurology, New York, NY 10032, and Cecil B. Day Laboratory for Neuromuscular Research, Massachusetts General Hospital, Charlestown 02129, USA.

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http://dx.doi.org/10.1016/j.brainres.2006.08.079DOI Listing
November 2006

Artemin crystal structure reveals insights into heparan sulfate binding.

Biochemistry 2006 Jun;45(22):6801-12

Department of Drug Discovery, Biogen Idec, Inc., 12 Cambridge Center, Cambridge, Massachusetts 02142, USA.

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http://dx.doi.org/10.1021/bi060035xDOI Listing
June 2006

Disulfide structure of the leucine-rich repeat C-terminal cap and C-terminal stalk region of Nogo-66 receptor.

Biochemistry 2005 Dec;44(50):16491-501

Biogenidec, Inc., 14 Cambridge Center, Cambridge, Massachusetts 02142, USA.

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http://pubs.acs.org/doi/abs/10.1021/bi0517483
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http://dx.doi.org/10.1021/bi0517483DOI Listing
December 2005

Tetanus toxin fragment C fusion facilitates protein delivery to CNS neurons from cerebrospinal fluid in mice.

J Neurochem 2005 Nov;95(4):1118-31

Cecil B. Day Laboratory for Neuromuscular Research, Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA.

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http://dx.doi.org/10.1111/j.1471-4159.2005.03459.xDOI Listing
November 2005

LINGO-1 negatively regulates myelination by oligodendrocytes.

Nat Neurosci 2005 Jun 15;8(6):745-51. Epub 2005 May 15.

Department of Discovery Biology, Biogen Idec, Inc., 14 Cambridge Center, Cambridge, Massachusetts 02142, USA.

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http://dx.doi.org/10.1038/nn1460DOI Listing
June 2005

LINGO-1 is a component of the Nogo-66 receptor/p75 signaling complex.

Nat Neurosci 2004 Mar 15;7(3):221-8. Epub 2004 Feb 15.

Department of Discovery Biology, Biogen Idec, Inc., 14 Cambridge Center, Cambridge, Massachusetts 02142, USA.

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http://dx.doi.org/10.1038/nn1188DOI Listing
March 2004

Comparative biological responses to human Sonic, Indian, and Desert hedgehog.

Mech Dev 2001 Aug;106(1-2):107-17

Department of Genetics, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1016/s0925-4773(01)00427-0DOI Listing
August 2001

The morphogen Sonic hedgehog is an indirect angiogenic agent upregulating two families of angiogenic growth factors.

Nat Med 2001 Jun;7(6):706-11

Department of Medicine, St. Elizabeth's Medical Center, Tufts University School of Medicine, Boston, Massachusetts, USA.

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http://www.nature.com/articles/nm0601_706
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http://dx.doi.org/10.1038/89083DOI Listing
June 2001