Blaise A Clarke

Blaise A Clarke

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Blaise A Clarke

Publications by authors named "Blaise A Clarke"

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HPV-independent Vulvar Squamous Cell Carcinoma is Associated With Significantly Worse Prognosis Compared With HPV-associated Tumors.

Int J Gynecol Pathol 2019 Jul 3. Epub 2019 Jul 3.

Department of Pathology and Laboratory Medicine, Henry Ford Health System, Detroit, Michigan (G.A.) Departments of Radiation Oncology (M.L.Y., J.C., M.M.) Obstetrics and Gynecology, Division of Gynecologic Oncology (S.F.) Medical Oncology (H.M.) Laboratory Medicine and Pathobiology (S.K.R., I.W., D.G., B.A.C.) Biostatistics (M.P.), Princess Margaret Cancer Centre/University Health Network, and University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1097/PGP.0000000000000620DOI Listing
July 2019

Metastatic low-grade endometrial stromal sarcoma of uterus presenting as a primary pancreatic tumor: case presentation and literature review.

Diagn Pathol 2019 Apr 22;14(1):30. Epub 2019 Apr 22.

Department of Anatomical Pathology, Laboratory Medicine Program, University Health Network, Toronto General Hospital, 200 Elizabeth Street, 11th Floor, Eaton Wing, Toronto, Ontario, M5G 2C4, Canada.

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http://dx.doi.org/10.1186/s13000-019-0807-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6477712PMC
April 2019

Expanding the morphological spectrum of ovarian microcystic stromal tumour.

Histopathology 2019 Feb 5;74(3):443-451. Epub 2018 Dec 5.

Cancer Research Program, Research Institute, McGill University Health Centre, Montreal, QC, Canada.

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http://doi.wiley.com/10.1111/his.13755
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http://dx.doi.org/10.1111/his.13755DOI Listing
February 2019

Neoadjuvant therapy in gynaecological malignancies: What pathologists need to know.

J Clin Pathol 2019 Feb;72(2):102-111

Department of Anatomical Pathology, Laboratory Medicine Program, University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1136/jclinpath-2018-205634DOI Listing
February 2019

Regulatory T Cells in Ovarian Cancer Are Characterized by a Highly Activated Phenotype Distinct from that in Melanoma.

Clin Cancer Res 2018 11 31;24(22):5685-5696. Epub 2018 Jul 31.

The Campbell Family Institute for Breast Cancer Research, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1158/1078-0432.CCR-18-0554DOI Listing
November 2018

Inhibitory Projections in the Mouse Auditory Tectothalamic System.

Brain Sci 2018 Jun 9;8(6). Epub 2018 Jun 9.

Department of Comparative Biomedical Sciences, LSU School of Veterinary Medicine, Baton Rouge, LA 70803, USA.

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http://www.mdpi.com/2076-3425/8/6/103
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http://dx.doi.org/10.3390/brainsci8060103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6025108PMC
June 2018

Genomic profiling identifies amplification in association with sarcomatous transformation in a subset of uterine carcinosarcomas.

J Pathol Clin Res 2018 Jan 24;4(1):69-78. Epub 2018 Jan 24.

Department of PathologyUniversity Health Network, University of TorontoTorontoCanada.

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http://dx.doi.org/10.1002/cjp2.89DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5783974PMC
January 2018

DICER1 Mutations Are Consistently Present in Moderately and Poorly Differentiated Sertoli-Leydig Cell Tumors.

Am J Surg Pathol 2017 Sep;41(9):1178-1187

*Department of Human Genetics, McGill University †Segal Cancer Centre, Lady Davis Institute, Jewish General Hospital ¶Research Institute of the McGill University Health Centre, Montréal, QC, Canada ‡Department of Laboratory Medicine and Pathobiology, University Health Network, University of Toronto, Toronto, ON, Canada §Department of Pathology, Belfast Health and Social Care Trust, Royal Group of Hospitals Trust, Belfast, United Kingdom ∥School for Women's and Infants' Health, University of Western Australia, Perth, WA, Australia.

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http://dx.doi.org/10.1097/PAS.0000000000000895DOI Listing
September 2017

Clinical, morphological and immunohistochemical evidence that small-cell carcinoma of the ovary of hypercalcaemic type (SCCOHT) may be a primitive germ-cell neoplasm.

Histopathology 2017 Jun 20;70(7):1147-1154. Epub 2017 Mar 20.

Department of Human Genetics, McGill University, Montreal, Quebec, Canada.

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http://dx.doi.org/10.1111/his.13177DOI Listing
June 2017

Ovarian carcinoma histotype in Lynch syndrome.

Gynecol Oncol Rep 2017 May 16;20:140-141. Epub 2017 Mar 16.

Dept of Human Genetics, McGill University, Montreal, QC, Canada.

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http://dx.doi.org/10.1016/j.gore.2017.03.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5993521PMC
May 2017

Somatic BRCA1/2 Recovery as a Resistance Mechanism After Exceptional Response to Poly (ADP-ribose) Polymerase Inhibition.

J Clin Oncol 2017 Apr 21;35(11):1240-1249. Epub 2017 Feb 21.

Stephanie Lheureux, Jeff P. Bruce, Julia V. Burnier, Katherine Karakasis, S.Y. Cindy Yang, Rene Quevedo, Tiantian Li, Mark Dowar, Valerie Bowering, Trevor J. Pugh, and Amit M. Oza, Princess Margaret Cancer Centre; Stephanie Lheureux, Patricia A. Shaw, Blaise A. Clarke, S.Y. Cindy Yang, Rene Quevedo, Trevor J. Pugh, and Amit M. Oza, University of Toronto; Patricia A. Shaw and Blaise A. Clarke, University Health Network, Toronto, Canada.

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http://dx.doi.org/10.1200/JCO.2016.71.3677DOI Listing
April 2017

Prophylactic Gynecologic Specimens from Hereditary Cancer Carriers.

Surg Pathol Clin 2016 Jun;9(2):307-28

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada; Department of Pathology, University Health Network, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.path.2016.02.002DOI Listing
June 2016

Gynecologic Pathology.

Surg Pathol Clin 2016 Jun;9(2):ix-x

Department of Pathology, Royal Victoria Hospital, Grosvenor Road, Belfast BT12BA, UK. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S18759181163000
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http://dx.doi.org/10.1016/j.path.2016.04.001DOI Listing
June 2016

Developing a prognostic micro-RNA signature for human cervical carcinoma.

PLoS One 2015 16;10(4):e0123946. Epub 2015 Apr 16.

Ontario Cancer Institute, University Health Network, Toronto, ON, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada; Department of Radiation Oncology, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada; Department of Radiation Oncology, University of Toronto, Toronto, ON, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0123946PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4399941PMC
May 2016

Ovarian hilar proliferations resembling Sertoli cell tumours: microscopic neoplasms or non-neoplastic remnants?

Histopathology 2016 Mar 4;68(4):596-602. Epub 2015 Sep 4.

Department of Pathology, Belfast Health and Social Care Trust, Belfast, UK.

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http://dx.doi.org/10.1111/his.12784DOI Listing
March 2016

In-depth molecular profiling of the biphasic components of uterine carcinosarcomas.

J Pathol Clin Res 2015 Jul 9;1(3):173-85. Epub 2015 Apr 9.

Department of Laboratory Medicine and Pathology Royal Alexandra Hospital and University of Alberta Edmonton Canada.

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http://dx.doi.org/10.1002/cjp2.18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4939881PMC
July 2015

Microscopic extraovarian sex cord proliferations: an undescribed phenomenon.

Histopathology 2015 Mar 22;66(4):555-64. Epub 2014 Dec 22.

Department of Pathology, Belfast Health and Social Care Trust, Belfast, UK.

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http://dx.doi.org/10.1111/his.12580DOI Listing
March 2015

Performance characteristics of screening strategies for Lynch syndrome in unselected women with newly diagnosed endometrial cancer who have undergone universal germline mutation testing.

Cancer 2014 Dec 31;120(24):3932-9. Epub 2014 Jul 31.

Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Princess Margaret Hospital/University Health Network, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/cncr.28933DOI Listing
December 2014

Current morphologic criteria perform poorly in identifying hereditary leiomyomatosis and renal cell carcinoma syndrome-associated uterine leiomyomas.

Int J Gynecol Pathol 2014 Nov;33(6):560-7

Department of Laboratory Medicine and Pathobiology (S.A.), Sunnybrook Health Sciences Centre Department of Pediatric Laboratory Medicine (C.C.), The Hospital For Sick Children Department of Laboratory Medicine and Pathobiology (A.M.M., B.A.C.), University Health Network, University of Toronto, Toronto, ON Department of Pathology (S.K., C.B.G.), University of British Columbia, Vancouver, BC, Canada Dammam Regional Laboratory (S.A.), Ministry of Health, Dammam, Saudi Arabia Department of Histopathology (M.E.B.), Imperial College, Hammersmith Hospital, London Molecular and Population Genetics Laboratory (I.P.T.), Wellcome Trust Centre for Human Genetics Oxford Biomedical Research Centre (I.P.T.), Wellcome Trust Centre for Human Genetics Henry Wellcome Building for Molecular Physiology (P.J.P.), University of Oxford, Oxford Department of Pathology (W.G.M.), Royal Group of Hospitals Trust, Northern Ireland, UK Department of Pathology and Microbiology (N.A.), Jordan University of Science and Technology, Ar Ramtha, Jordan Department of Pathology (T.B.P.), B.P.Koirala Memorial Cancer Hospital, Chitwan, Nepal.

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https://insights.ovid.com/crossref?an=00004347-201411000-000
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http://dx.doi.org/10.1097/PGP.0000000000000091DOI Listing
November 2014

Novel PRKD gene rearrangements and variant fusions in cribriform adenocarcinoma of salivary gland origin.

Genes Chromosomes Cancer 2014 Oct 18;53(10):845-56. Epub 2014 Jun 18.

Department of Pathology, University Health Network, Toronto, ON, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1002/gcc.22195DOI Listing
October 2014

The histomorphology of Lynch syndrome-associated ovarian carcinomas: toward a subtype-specific screening strategy.

Am J Surg Pathol 2014 Sep;38(9):1173-81

Departments of *Laboratory Medicine and Pathobiology ‡Obstetrics and Gynecology, Faculty of Medicine, University of Toronto §Division of Gynecologic Oncology §§Department of Pathology, University Health Network ∥Department of Laboratory Medicine and Pathology ¶Zane Cohen Centre for Digestive Diseases, Familial Gastrointestinal Cancer Registry ‡‡Division of General Surgery, Mount Sinai Hospital, Toronto, ON ∥∥Department of Medical Genetics, McGill University Health Centre, Montreal, QB #Division of Gynecologic Oncology ¶¶Department of Pathology and Laboratory Medicine, Faculty of Medicine, University of British Columbia and BC Cancer Agency, Vancouver, BC, Canada †Department of Pathology, Bon Secours Hospital, Cork, Ireland **Department of Histopathology, King Edward Memorial Hospital for Women, Perth, Australia ††Department of Cellular Pathology, Barts Health NHS Trust, London, United Kingdom.

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http://pdfs.journals.lww.com/ajsp/2014/09000/The_Histomorpho
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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/PAS.0000000000000298DOI Listing
September 2014

No small surprise - small cell carcinoma of the ovary, hypercalcaemic type, is a malignant rhabdoid tumour.

J Pathol 2014 Jul 20;233(3):209-14. Epub 2014 May 20.

Department of Medical Genetics, Lady Davis Institute and Segal Cancer Centre, Jewish General Hospital, McGill University, Montreal, QC, Canada; Department of Human Genetics, McGill University, Montreal, QC, Canada; Department of Medical Genetics, Research Institute, McGill University Health Centre, Montreal, QC, Canada.

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http://dx.doi.org/10.1002/path.4362DOI Listing
July 2014

Displaced granulosa cells within the ovarian stroma in a BRCA1 mutation carrier.

Int J Gynecol Pathol 2014 Jul;33(4):423-4

Department of Laboratory Medicine and Pathobiology, (M.H.C., W.B.C., B.A.C.), Faculty of Medicine, University of Toronto Department of Pathology, (M.H.C., B.A.C.), Toronto General Hospital, University Health Network Department of Pathology, (W.B.C.), St Joseph's Health Centre, Toronto, ON, Canada.

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http://dx.doi.org/10.1097/PGP.0b013e3182a3cd2cDOI Listing
July 2014

Fertility sparing treatment of complex atypical hyperplasia and low grade endometrial cancer using oral progestin.

Gynecol Oncol 2014 May 19;133(2):229-33. Epub 2014 Feb 19.

Department of Obstetrics & Gynecology, University of Toronto, Division of Gynecologic Oncology, Princess Margaret Hospital/University Health Network, 610 University Ave M 700, Toronto, Ontario M5G 2M9, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.ygyno.2014.02.020DOI Listing
May 2014

Germline and somatic SMARCA4 mutations characterize small cell carcinoma of the ovary, hypercalcemic type.

Nat Genet 2014 May 23;46(5):438-43. Epub 2014 Mar 23.

1] Program in Cancer Genetics, Department of Oncology and Human Genetics, McGill University, Montreal, Quebec, Canada. [2] Department of Medical Genetics, Lady Davis Institute and Segal Cancer Centre, Jewish General Hospital, McGill University, Montreal, Quebec, Canada. [3] Department of Human Genetics, McGill University, Montreal, Quebec, Canada. [4] Department of Medical Genetics, Research Institute, McGill University Health Centre, Montreal, Quebec, Canada.

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http://www.nature.com/articles/ng.2931
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http://dx.doi.org/10.1038/ng.2931DOI Listing
May 2014

Frequent somatic mutations of the telomerase reverse transcriptase promoter in ovarian clear cell carcinoma but not in other major types of gynaecological malignancy.

J Pathol 2014 Mar;232(4):473-81

Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD, USA; Department of Pathology, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Taoyuan, Taiwan.

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http://dx.doi.org/10.1002/path.4315DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3946218PMC
March 2014

ARID1A loss correlates with mismatch repair deficiency and intact p53 expression in high-grade endometrial carcinomas.

Mod Pathol 2014 Feb 26;27(2):255-61. Epub 2013 Jul 26.

1] Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada [2] Department of Pathology, Toronto General Hospital, University Health Network, Toronto, ON,Canada.

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http://dx.doi.org/10.1038/modpathol.2013.144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4603563PMC
February 2014

Uterine adenosarcomas: a dual-institution update on staging, prognosis and survival.

Gynecol Oncol 2013 Dec 14;131(3):634-9. Epub 2013 Oct 14.

Department of Medical Oncology, Princess Margaret Hospital, University of Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.ygyno.2013.09.011DOI Listing
December 2013

Identifying Lynch syndrome in patients with ovarian carcinoma: the significance of tumor subtype.

Adv Anat Pathol 2013 Nov;20(6):378-86

*Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto §Department of Pathology, Toronto General Hospital, University Health Network, Toronto, ON †Department of Pathology and Laboratory Medicine, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada ‡Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA.

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http://dx.doi.org/10.1097/PAP.0b013e3182a92cf8DOI Listing
November 2013

A phase Ib combination study of RO4929097, a gamma-secretase inhibitor, and temsirolimus in patients with advanced solid tumors.

Invest New Drugs 2013 Oct 17;31(5):1182-91. Epub 2013 Jul 17.

Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, Department of Medicine, University of Toronto, 610 University Avenue, 5-125, M5G 2M9, Toronto, ON, Canada.

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http://link.springer.com/10.1007/s10637-013-0001-5
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http://dx.doi.org/10.1007/s10637-013-0001-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3771370PMC
October 2013

Hormone-receptor expression and ovarian cancer survival: an Ovarian Tumor Tissue Analysis consortium study.

Lancet Oncol 2013 Aug 9;14(9):853-62. Epub 2013 Jul 9.

Division of Epidemiology, Department of Health Research and Policy, Stanford University, Stanford, CA, USA.

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http://dx.doi.org/10.1016/S1470-2045(13)70253-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4006367PMC
August 2013

Endometrial sarcomas: an immunohistochemical and JAZF1 re-arrangement study in low-grade and undifferentiated tumors.

Mod Pathol 2013 Jan 24;26(1):95-105. Epub 2012 Aug 24.

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1038/modpathol.2012.136DOI Listing
January 2013

Prevalence of loss of expression of DNA mismatch repair proteins in primary epithelial ovarian tumors.

Int J Gynecol Pathol 2012 Nov;31(6):524-31

Department of Pathology and Laboratory Medicine, Vancouver General Hospital, University of British Columbia, Vancouver, Canada.

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http://dx.doi.org/10.1097/PGP.0b013e31824fe2aaDOI Listing
November 2012

Biologic rationale and clinical activity of mTOR inhibitors in gynecological cancer.

Cancer Treat Rev 2012 Oct 29;38(6):767-75. Epub 2012 Feb 29.

Division of Medical Oncology, Princess Margaret Hospital, University of Toronto, Ontario, Canada.

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http://dx.doi.org/10.1016/j.ctrv.2012.02.001DOI Listing
October 2012

Identifying Lynch syndrome in patients with endometrial carcinoma: shortcomings of morphologic and clinical schemas.

Adv Anat Pathol 2012 Jul;19(4):231-8

Department of Laboratory Medicine, University of Toronto, ON, Canada.

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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/PAP.0b013e31825c6b76DOI Listing
July 2012

Calculator for ovarian carcinoma subtype prediction.

Mod Pathol 2011 Apr 3;24(4):512-21. Epub 2010 Dec 3.

Genetic Pathology Evaluation Centre, Vancouver, BC, Canada.

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http://dx.doi.org/10.1038/modpathol.2010.215DOI Listing
April 2011

Leiomyosarcoma of the broad ligament with osteoclast-like giant cells and rhabdoid cells.

Int J Gynecol Pathol 2010 Sep;29(5):432-7

Department of Pathology, Laboratory Medicine Programme, University Health Network/University of Toronto, 200 Elizabeth Street, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1097/PGP.0b013e3181d32106DOI Listing
September 2010

Endometrial carcinoma: controversies in histopathological assessment of grade and tumour cell type.

J Clin Pathol 2010 May;63(5):410-5

Department of Pathology and Laboratory Medicine, University Health Network, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1136/jcp.2009.071225DOI Listing
May 2010

Primary frozen section diagnosis by robotic microscopy and virtual slide telepathology: the University Health Network experience.

Semin Diagn Pathol 2009 Nov;26(4):165-76

Department of Pathology Laboratory Medicine Program, University Health Network, Toronto, Ontario, Canada.

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November 2009