Publications by authors named "Blair R Leavitt"

155Publications

Editorial.

J Huntingtons Dis 2021 ;10(1)

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January 2021

Composite UHDRS Correlates With Progression of Imaging Biomarkers in Huntington's Disease.

Mov Disord 2021 Jan 20. Epub 2021 Jan 20.

Huntington's Disease Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK.

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January 2021

Spontaneous, solvent-free entrapment of siRNA within lipid nanoparticles.

Nanoscale 2020 Dec 26;12(47):23959-23966. Epub 2020 Nov 26.

NanoMedicines Innovation Network, Vancouver, British Columbia, Canada.

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December 2020

A novel mouse model for pyridoxine-dependent epilepsy due to antiquitin deficiency.

Hum Mol Genet 2020 Nov;29(19):3266-3284

Centre for Molecular Medicine and Therapeutics, BC Children's Hospital Research Institute, Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada.

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November 2020

Longitudinal Structural MRI in Neurologically Healthy Adults.

J Magn Reson Imaging 2020 11 29;52(5):1385-1399. Epub 2020 May 29.

Department of Neurology, Ulm University Hospital, Ulm, Germany.

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November 2020

Antisense oligonucleotides for neurodegeneration.

Science 2020 Mar;367(6485):1428-1429

Huntington's Disease Centre, Department of Neurodegenerative Disease, and UK Dementia Research Institute at UCL, UCL Queen Square Institute of Neurology, University College London, London, UK.

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March 2020

Isolating cells from adult murine brain for validation of cell-type specific cre-mediated deletion.

J Neurosci Methods 2019 12 4;328:108422. Epub 2019 Sep 4.

Centre for Molecular Medicine and Therapeutics, Department of Medical Genetics, University of British Columbia and Children's and Women's Hospital, 980 West 28thAvenue, Vancouver, BC, V5Z 4H4, Canada; Division of Neurology, Department of Medicine, University of British Columbia Hospital, S 192-2211 Wesbrook Mall, Vancouver, BC, V6T 2B5, Canada; Brain Research Center, University of British Columbia, Vancouver, BC, V6T 1Z3, Canada. Electronic address:

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December 2019

Targeting Huntingtin Expression in Patients with Huntington's Disease.

N Engl J Med 2019 06 6;380(24):2307-2316. Epub 2019 May 6.

From University College London (UCL) Huntington's Disease Centre, Department of Neurodegenerative Disease, Queen Square Institute of Neurology, UCL, and the U.K. Dementia Research Institute at UCL, London (S.J.T., E.J.W.), the Department of Clinical Neuroscience, Addenbrooke's Hospital, University of Cambridge, Cambridge (R.A.B., N.F.B.), Manchester Centre for Genomic Medicine, St. Mary's Hospital, Manchester University NHS Foundation Trust, and the Division of Evolution and Genomic Sciences, School of Biological Sciences, Faculty of Biology, Medicine, and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester (D.C.), the University of Edinburgh and the U.K. Dementia Research Institute, Edinburgh (J.P.), the Institute of Clinical Sciences, College of Medical and Dental Sciences, University Hospital Birmingham, Birmingham (H.R.), and the Cardiff University Brain Repair Group, Brain Repair and Intracranial Neurotherapeutics Unit, Neuroscience and Mental Health Research Institute and School of Biosciences, Cardiff (A.R.) - all in the United Kingdom; the Centre for Huntington's Disease, Department of Medical Genetics, and the Division of Neurology, Department of Medicine, University of British Columbia, and the Centre for Molecular Medicine and Therapeutics, B.C. Children's Hospital, Vancouver, Canada (B.R.L.); the Department of Neurology, Ulm University, Huntington's Disease Centre, Ulm (G.B.L.), the Department of Neurology, Huntington Center North Rhine-Westphalia, Ruhr University Bochum, St. Josef-Hospital, Bochum (C.S.), and the Department of Neuropsychiatry, Charité-Universitätsmedizin Berlin, Deutsches Zentrum für Neurodegenerative Erkrankungen, Berlin (J.P.) - all in Germany; Ionis Pharmaceuticals, Carlsbad, CA (H.B.K., E.E.S., D.A.N., T.B., E.P., A.V.S., C.F.B., R.M.L.); and F. Hoffmann-La Roche, Basel, Switzerland (C.C., I.G., S.A.S.).

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June 2019

Huntingtin Lowering Strategies for Disease Modification in Huntington's Disease.

Neuron 2019 03;101(5):801-819

UBC Centre for Huntington's Disease, Department of Medical Genetics and Centre for Molecular Medicine and Therapeutics, BC Children's Hospital, University of British Columbia, Vancouver, BC, Canada.

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March 2019

Mutant huntingtin expression in microglia is neither required nor sufficient to cause the Huntington's disease-like phenotype in BACHD mice.

Hum Mol Genet 2019 05;28(10):1661-1670

Centre for Molecular Medicine & Therapeutics, Department of Medical Genetics, University of British Columbia, and Children's and Women's Hospital, Vancouver, BC, Canada.

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May 2019

Altered Intracortical T-Weighted/T-Weighted Ratio Signal in Huntington's Disease.

Front Neurosci 2018 5;12:805. Epub 2018 Nov 5.

Department of Psychology, Neuroscience and Behaviour, McMaster University, Hamilton, ON, Canada.

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November 2018

Transcriptional Regulation of the Huntingtin Gene.

J Huntingtons Dis 2018 ;7(4):289-296

Department of Medical Genetics, Centre for Molecular Medicine and Therapeutics, University of British Columbia, and BC Children's Hospital, Vancouver, BC, Canada.

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October 2019