Blair Leavitt

Blair Leavitt

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Blair Leavitt

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Editorial on Clinical Trial's Corner.

J Huntingtons Dis 2018 ;7(1):87

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http://dx.doi.org/10.3233/JHD-189000DOI Listing
October 2019

Computational Analysis of Transcriptional Regulation Sites at the HTT Gene Locus.

J Huntingtons Dis 2018 ;7(3):223-237

Department of Medical Genetics, Centre for Molecular Medicine and Therapeutics, BC Children's Hospital, University of British Columbia, Vancouver, BC, Canada.

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http://www.medra.org/servlet/aliasResolver?alias=iospress&am
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http://dx.doi.org/10.3233/JHD-170272DOI Listing
October 2019

Isolating cells from adult murine brain for validation of cell-type specific cre-mediated deletion.

J Neurosci Methods 2019 Sep 4;328:108422. Epub 2019 Sep 4.

Centre for Molecular Medicine and Therapeutics, Department of Medical Genetics, University of British Columbia and Children's and Women's Hospital, 980 West 28thAvenue, Vancouver, BC, V5Z 4H4, Canada; Division of Neurology, Department of Medicine, University of British Columbia Hospital, S 192-2211 Wesbrook Mall, Vancouver, BC, V6T 2B5, Canada; Brain Research Center, University of British Columbia, Vancouver, BC, V6T 1Z3, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jneumeth.2019.108422DOI Listing
September 2019

Movement Disorder Society Task Force Viewpoint: Huntington's Disease Diagnostic Categories.

Mov Disord Clin Pract 2019 Sep 23;6(7):541-546. Epub 2019 Aug 23.

Huntington's Disease Centre, University College London Queen Square Institute of Neurology London United Kingdom.

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http://dx.doi.org/10.1002/mdc3.12808DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6749806PMC
September 2019

Targeting Huntingtin Expression in Patients with Huntington's Disease.

N Engl J Med 2019 06 6;380(24):2307-2316. Epub 2019 May 6.

From University College London (UCL) Huntington's Disease Centre, Department of Neurodegenerative Disease, Queen Square Institute of Neurology, UCL, and the U.K. Dementia Research Institute at UCL, London (S.J.T., E.J.W.), the Department of Clinical Neuroscience, Addenbrooke's Hospital, University of Cambridge, Cambridge (R.A.B., N.F.B.), Manchester Centre for Genomic Medicine, St. Mary's Hospital, Manchester University NHS Foundation Trust, and the Division of Evolution and Genomic Sciences, School of Biological Sciences, Faculty of Biology, Medicine, and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester (D.C.), the University of Edinburgh and the U.K. Dementia Research Institute, Edinburgh (J.P.), the Institute of Clinical Sciences, College of Medical and Dental Sciences, University Hospital Birmingham, Birmingham (H.R.), and the Cardiff University Brain Repair Group, Brain Repair and Intracranial Neurotherapeutics Unit, Neuroscience and Mental Health Research Institute and School of Biosciences, Cardiff (A.R.) - all in the United Kingdom; the Centre for Huntington's Disease, Department of Medical Genetics, and the Division of Neurology, Department of Medicine, University of British Columbia, and the Centre for Molecular Medicine and Therapeutics, B.C. Children's Hospital, Vancouver, Canada (B.R.L.); the Department of Neurology, Ulm University, Huntington's Disease Centre, Ulm (G.B.L.), the Department of Neurology, Huntington Center North Rhine-Westphalia, Ruhr University Bochum, St. Josef-Hospital, Bochum (C.S.), and the Department of Neuropsychiatry, Charité-Universitätsmedizin Berlin, Deutsches Zentrum für Neurodegenerative Erkrankungen, Berlin (J.P.) - all in Germany; Ionis Pharmaceuticals, Carlsbad, CA (H.B.K., E.E.S., D.A.N., T.B., E.P., A.V.S., C.F.B., R.M.L.); and F. Hoffmann-La Roche, Basel, Switzerland (C.C., I.G., S.A.S.).

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http://dx.doi.org/10.1056/NEJMoa1900907DOI Listing
June 2019

Mutant huntingtin expression in microglia is neither required nor sufficient to cause the Huntington's disease-like phenotype in BACHD mice.

Hum Mol Genet 2019 May;28(10):1661-1670

Centre for Molecular Medicine & Therapeutics, Department of Medical Genetics, University of British Columbia, and Children's and Women's Hospital, Vancouver, BC, Canada.

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http://dx.doi.org/10.1093/hmg/ddz009DOI Listing
May 2019

Huntingtin Lowering Strategies for Disease Modification in Huntington's Disease.

Neuron 2019 03;101(5):801-819

UBC Centre for Huntington's Disease, Department of Medical Genetics and Centre for Molecular Medicine and Therapeutics, BC Children's Hospital, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.1016/j.neuron.2019.01.039DOI Listing
March 2019

Murine Models of Huntington's Disease for Evaluating Therapeutics.

Methods Mol Biol 2018 ;1780:179-207

Centre for Molecular Medicine and Therapeutics, and Department of Medical Genetics, BC Children's Hospital Research Institute, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.1007/978-1-4939-7825-0_10DOI Listing
February 2019

Executive impairment is associated with unawareness of neuropsychiatric symptoms in premanifest and early Huntington's disease.

Neuropsychology 2018 Nov 13;32(8):958-965. Epub 2018 Sep 13.

Monash Institute of Cognitive and Clinical Neurosciences, School of Psychological Sciences, Monash University.

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http://dx.doi.org/10.1037/neu0000479DOI Listing
November 2018

Altered Intracortical T-Weighted/T-Weighted Ratio Signal in Huntington's Disease.

Front Neurosci 2018 5;12:805. Epub 2018 Nov 5.

Department of Psychology, Neuroscience and Behaviour, McMaster University, Hamilton, ON, Canada.

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http://dx.doi.org/10.3389/fnins.2018.00805DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6230564PMC
November 2018

Epidemiology of Huntington disease.

Handb Clin Neurol 2017 ;144:31-46

Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, BC, Canada. Electronic address:

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http://dx.doi.org/10.1016/B978-0-12-801893-4.00003-1DOI Listing
March 2018

Brain Regions Showing White Matter Loss in Huntington's Disease Are Enriched for Synaptic and Metabolic Genes.

Biol Psychiatry 2018 03 26;83(5):456-465. Epub 2017 Oct 26.

Huntington's Disease Centre, Department of Neurodegenerative Disease, Queen Square, London, United Kingdom; National Hospital for Neurology and Neurosurgery, Queen Square, London, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.biopsych.2017.10.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5803509PMC
March 2018

Neurofilament light protein in blood predicts regional atrophy in Huntington disease.

Neurology 2018 02 24;90(8):e717-e723. Epub 2018 Jan 24.

From the Huntington's Disease Research Centre (E.B.J., L.M.B., S.G., F.B.R., S.J.T., R.I.S., E.J.W.), UCL Institute of Neurology, London, UK; Clinical Neurochemistry Laboratory (K.B., H.Z.), Sahlgrenska University Hospital, Mölndal, Sweden; Institut du Cerveau et de la Moelle épinière (A.D.), Sorbonne Universités, UPMC University Paris 06, UMRS 1127, INSERM, U 1127, CNRS, UMR 7225; APHP (A.D.), Genetics Department, Pitié-Salpêtrière University Hospital, Paris, France; Centre for Molecular Medicine and Therapeutics (B.R.L.), University of British Columbia, Vancouver, BC, Canada; Department of Neurology (R.A.R.), Leiden University, the Netherlands; Department of Molecular Neuroscience (H.Z.), UCL Institute of Neurology, Queen Square, London, UK; Department of Psychiatry and Neurochemistry (H.Z.), Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden; and UK Dementia Research Institute (H.Z.), London, UK.

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http://dx.doi.org/10.1212/WNL.0000000000005005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5818166PMC
February 2018

Transcriptional Regulation of the Huntingtin Gene.

J Huntingtons Dis 2018 ;7(4):289-296

Department of Medical Genetics, Centre for Molecular Medicine and Therapeutics, University of British Columbia, and BC Children's Hospital, Vancouver, BC, Canada.

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http://dx.doi.org/10.3233/JHD-180331DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294578PMC
January 2018

Motor, cognitive, and functional declines contribute to a single progressive factor in early HD.

Neurology 2017 Dec 15;89(24):2495-2502. Epub 2017 Nov 15.

From F. Hoffman-La Roche, Ltd (S.A.S., G.P., O.S.K., D.T., J.J.S.), Roche Innovation Center, Basel, Switzerland; University of Rochester (P.A., S.M., E.R.D., K.D.K.), NY; University of Iowa (J.D.L., D.R.L.), Iowa City; Massachusetts General Hospital and Harvard Medical School (M.C., S.H.), Boston; CHDI Management/Foundation (C.S.), Princeton, NJ; University of British Columbia, Vancouver, Canada (B.R.L.); and University College London (S.J.T.), UK.

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http://dx.doi.org/10.1212/WNL.0000000000004743DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5729794PMC
December 2017

Survival End Points for Huntington Disease Trials Prior to a Motor Diagnosis.

JAMA Neurol 2017 11;74(11):1352-1360

Huntington's Disease Centre, Department of Neurodegenerative Disease, Institute of Neurology, University College London, Queen Square, London, England.

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http://dx.doi.org/10.1001/jamaneurol.2017.2107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5710578PMC
November 2017

Selective depletion of microglial progranulin in mice is not sufficient to cause neuronal ceroid lipofuscinosis or neuroinflammation.

J Neuroinflammation 2017 Nov 17;14(1):225. Epub 2017 Nov 17.

Centre for Molecular Medicine and Therapeutics, Department of Medical Genetics, University of British Columbia, and Children's and Women's Hospital, 980 West 28th Avenue, Vancouver, BC, V5Z 4H4, Canada.

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http://dx.doi.org/10.1186/s12974-017-1000-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5693502PMC
November 2017

Conditional loss of progranulin in neurons is not sufficient to cause neuronal ceroid lipofuscinosis-like neuropathology in mice.

Neurobiol Dis 2017 Oct 21;106:14-22. Epub 2017 Jun 21.

Centre for Molecular Medicine & Therapeutics, Department of Medical Genetics, University of British Columbia, and Children's and Women's Hospital, 980 West 28th Avenue, Vancouver, BC V5Z 4H4, Canada; Division of Neurology, Department of Medicine, University of British Columbia Hospital, S 192 - 2211 Wesbrook Mall, Vancouver, BC V6T 2B5, Canada; Brain Research Centre, University of British Columbia, Vancouver, BC V6T 1Z3, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2017.06.012DOI Listing
October 2017

Recommendations for the Use of Automated Gray Matter Segmentation Tools: Evidence from Huntington's Disease.

Front Neurol 2017 10;8:519. Epub 2017 Oct 10.

Huntington's Disease Centre, UCL Institute of Neurology, University College London, London, United Kingdom.

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http://dx.doi.org/10.3389/fneur.2017.00519DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5641297PMC
October 2017

Identification of genetic variants associated with Huntington's disease progression: a genome-wide association study.

Lancet Neurol 2017 09 20;16(9):701-711. Epub 2017 Jun 20.

UCL Huntington's Disease Centre, University College London, London, UK. Electronic address:

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http://dx.doi.org/10.1016/S1474-4422(17)30161-8DOI Listing
September 2017

p35 hemizygosity activates Akt but does not improve motor function in the YAC128 mouse model of Huntington's disease.

Neuroscience 2017 06 6;352:79-87. Epub 2017 Apr 6.

Department of Medical Genetics, Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia V5Z 4H4, Canada; Division of Neurology, Department of Medicine, University of British Columbia, Vancouver, British Columbia V5Z 4H4, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.neuroscience.2017.03.051DOI Listing
June 2017

Introducing the "Clinical Trials Corner".

J Huntingtons Dis 2017 ;6(3):167

University of California, Irvine, CA, USA.

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http://dx.doi.org/10.3233/JHD-179003DOI Listing
January 2017

Potential biomarkers to follow the progression and treatment response of Huntington's disease.

J Exp Med 2016 11 7;213(12):2655-2669. Epub 2016 Nov 7.

Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305

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http://dx.doi.org/10.1084/jem.20160776DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5110026PMC
November 2016

Cerebrospinal fluid total tau concentration predicts clinical phenotype in Huntington's disease.

J Neurochem 2016 10 20;139(1):22-5. Epub 2016 Sep 20.

Huntington's Disease Centre, Institute of Neurology, University College London, London, UK.

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http://dx.doi.org/10.1111/jnc.13719DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5053298PMC
October 2016

Effect of Deutetrabenazine on Chorea Among Patients With Huntington Disease: A Randomized Clinical Trial.

JAMA 2016 Jul;316(1):40-50

Harvard University, Boston, Massachusetts.

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https://scholarworks.iupui.edu/bitstream/handle/1805/11938/F
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http://jama.jamanetwork.com/article.aspx?doi=10.1001/jama.20
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http://dx.doi.org/10.1001/jama.2016.8655DOI Listing
July 2016

Indoleamine 2,3 Dioxygenase as a Potential Therapeutic Target in Huntington's Disease.

J Huntingtons Dis 2015 ;4(2):109-18

Centre for Molecular Medicine & Therapeutics and Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.3233/JHD-159003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4923717PMC
June 2016

Decreasing Levels of the cdk5 Activators, p25 and p35, Reduces Excitotoxicity in Striatal Neurons.

J Huntingtons Dis 2012 ;1(1):89-96

Centre for Molecular Medicine and Therapeutics, Department of Medical Genetics, Child and Family Research Institute, University of British Columbia, Vancouver, BC, Canada ; Department of Medicine, Division of Neurology, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.3233/JHD-2012-129000DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3864911PMC
May 2016

Journal of Huntington's Disease.

J Huntingtons Dis 2012 ;1(1)

University of California, Irvine, CA, USA.

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http://dx.doi.org/10.3233/JHD-2012-120001DOI Listing
May 2016

Treatment of Huntington Disease and Comorbid Trichotillomania With Aripiprazole.

J Neuropsychiatry Clin Neurosci 2015 ;27(3):e211-2

University of British Columbia Hospital, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1176/appi.neuropsych.14090232DOI Listing
May 2016

DNA methylation profiling in human Huntington's disease brain.

Hum Mol Genet 2016 05 6;25(10):2013-2030. Epub 2016 Mar 6.

Department of Medical Genetics, Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, BC, Canada V5Z 4H4.

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http://dx.doi.org/10.1093/hmg/ddw076DOI Listing
May 2016

Large-scale brain network abnormalities in Huntington's disease revealed by structural covariance.

Hum Brain Mapp 2016 Jan 10;37(1):67-80. Epub 2015 Oct 10.

Department of Psychiatry and Psychotherapy, University Medical Center Freiburg, Freiburg, Germany.

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http://dx.doi.org/10.1002/hbm.23014DOI Listing
January 2016

Clinical-Genetic Associations in the Prospective Huntington at Risk Observational Study (PHAROS): Implications for Clinical Trials.

Authors:
Kevin Michael Biglan Ira Shoulson Karl Kieburtz David Oakes Elise Kayson M Aileen Shinaman Hongwei Zhao Megan Romer Anne Young Steven Hersch Jack Penney Karen Marder Jane Paulsen Kimberly Quaid Eric Siemers Caroline Tanner William Mallonee Greg Suter Richard Dubinsky Carolyn Gray Martha Nance Scott Bundlie Dawn Radtke Sandra Kostyk Corrine Baic James Caress Francis Walker Victoria Hunt Christine O'Neill Sylvain Chouinard Stewart Factor Timothy Greenamyre Cathy Wood-Siverio Jody Corey-Bloom David Song Guerry Peavy Carol Moskowitz Melissa Wesson Ali Samii Thomas Bird Hillary Lipe Karen Blindauer Frederick Marshall Carol Zimmerman Jody Goldstein Diana Rosas Peter Novak John Caviness Charles Adler Amy Duffy Vicki Wheelock Teresa Tempkin David Richman Lauren Seeberger Roger Albin Kelvin L Chou Brad Racette Joel S Perlmutter Susan Perlman Yvette Bordelon Wayne Martin Marguerite Wieler Blair Leavitt Lynn Raymond Joji Decolongon Lorne Clarke Joseph Jankovic Christine Hunter Robert A Hauser Juan Sanchez-Ramos Sarah Furtado Oksana Suchowersky Mary Lou Klimek Mark Guttman Rustom Sethna Andrew Feigin Marie Cox Barbara Shannon Alan Percy Leon Dure Madaline Harrison William Johnson Donald Higgins Eric Molho Constance Nickerson Sharon Evans Douglas Hobson Carlos Singer Nestor Galvez-Jimenez Kathleen Shannon Cynthia Comella Christopher Ross Marie H Saint-Hilaire Claudia Testa Adam Rosenblatt Penelope Hogarth William Weiner Peter Como Rajeev Kumar Candace Cotto Julie Stout Alicia Brocht Arthur Watts Shirley Eberly Christine Weaver Tatiana Foroud James Gusella Marcy MacDonald Richard Myers Stanley Fahn Clifford Shults

JAMA Neurol 2016 Jan;73(1):102-10

Department of Neuroscience, University of California, San Diego, La Jolla.

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http://dx.doi.org/10.1001/jamaneurol.2015.2736DOI Listing
January 2016

Detection of Motor Changes in Huntington's Disease Using Dynamic Causal Modeling.

Front Hum Neurosci 2015 25;9:634. Epub 2015 Nov 25.

Department of Psychiatry and Psychotherapy, University Medical Center Freiburg Freiburg, Germany ; Freiburg Brain Imaging Center, University Medical Center Freiburg Freiburg, Germany ; Department of Neurology, University Medical Center Freiburg Freiburg, Germany.

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http://dx.doi.org/10.3389/fnhum.2015.00634DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4658414PMC
December 2015

Reliability and factor structure of the Short Problem Behaviors Assessment for Huntington's disease (PBA-s) in the TRACK-HD and REGISTRY studies.

J Neuropsychiatry Clin Neurosci 2015 ;27(1):59-64

From the Cardiff University, School of Biosciences, Cardiff, United Kingdom (JC). Institute of Human Development, Faculty of Medicine and Human Sciences, University of Manchester and Manchester Academic Health Science Centre, Manchester, United Kingdom (CS, NA, DC); Manchester Centre for Genomic Medicine, Central Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom (CS, DC); Dept. of Neuropsychology, Salford Royal Hospital NHS Foundation Trust, Salford, United Kingdom (NA); Centre de Référence National pour la Maladie de Huntington, AP-HP, Groupe Henri Mondor-Albert Chenevier, Créteil, France (M-FB, A-CB-L, CB); University of British Columbia, The Centre for Huntington's disease, Vancouver, Canada (AC, RDS); Leiden University Medical Centre, Department of Neurology, Leiden, The Netherlands (EMD, EPH, RACR); UPMC UnivParis06, UMR_S975 and Inserm, UMR_S975, CRICM and CNRS UMR7225, F-75013, Paris, France (DJ, AD); University College London, Institute of Neurology, London, United Kingdom (GO, JR, MJS, SJT); Brain and Spine Institute (ICM), F-75013, Paris, France (AD); AP-HP Pitie-Salpetriere Hospital, Dept. of Genetics and Cytogenetics, F-75013, Paris, France (AD); University of British Columbia, Centre for Molecular Medicine and Therapeutics, Vancouver, Canada (BRL); Service de Psychiatrie, 93G18, EPSVE, 93330 Neuilly-sur-Marne, France (CB); and Dept. of Psychiatry, Leiden University Medical Centre, Leiden, The Netherlands (EvD).

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http://dx.doi.org/10.1176/appi.neuropsych.13070169DOI Listing
November 2015

Neurobiology of Huntington's Disease.

Curr Top Behav Neurosci 2015 ;22:81-100

Centre for Molecular Medicine and Therapeutics, Department of Medical Genetics, Child and Family Research Institute, University of British Columbia, 950 West 28th Avenue, Room 2020, Vancouver, BC, V5Z 4H4, Canada.

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http://dx.doi.org/10.1007/7854_2014_353DOI Listing
September 2015

Ultrasensitive measurement of huntingtin protein in cerebrospinal fluid demonstrates increase with Huntington disease stage and decrease following brain huntingtin suppression.

Sci Rep 2015 Jul 15;5:12166. Epub 2015 Jul 15.

Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, and Department of Medical Genetics, University of British Columbia, Vancouver, BC V5Z 4H4; Canada.

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http://dx.doi.org/10.1038/srep12166DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4502413PMC
July 2015

Direct intracerebral delivery of a miR-33 antisense oligonucleotide into mouse brain increases brain ABCA1 expression. [Corrected].

Neurosci Lett 2015 Jun 6;598:66-72. Epub 2015 May 6.

Centre for Molecular Medicine and Therapeutics, University of British Columbia, 950 West 28th Avenue, Vancouver, BC V5Z 4H4, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03043940150035
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http://dx.doi.org/10.1016/j.neulet.2015.05.007DOI Listing
June 2015

Huntington disease.

Nat Rev Dis Primers 2015 04 23;1:15005. Epub 2015 Apr 23.

Department of Neurodegenerative Disease, University College London Institute of Neurology, Queen Square, London WC1N 3BG, UK.

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http://dx.doi.org/10.1038/nrdp.2015.5DOI Listing
April 2015

A longitudinal study of magnetic resonance spectroscopy Huntington's disease biomarkers.

Mov Disord 2015 Mar 18;30(3):393-401. Epub 2015 Feb 18.

Centre for Molecular Medicine & Therapeutics, Vancouver, Canada; Centre for Huntington Disease, University of British Columbia (UBC) Hospital, Vancouver, Canada.

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http://dx.doi.org/10.1002/mds.26118DOI Listing
March 2015

Quality of life in Huntington's disease: a comparative study investigating the impact for those with pre-manifest and early manifest disease, and their partners.

J Huntingtons Dis 2013 ;2(2):159-75

University of Manchester, Manchester Academic Health Sciences Centre and Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK.

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http://dx.doi.org/10.3233/JHD-130051DOI Listing
October 2014

Aquatherapy for neurodegenerative disorders.

J Huntingtons Dis 2014 ;3(1):5-11

Centre for Huntington Disease, UBC Hospital and The Centre for Molecular Medicine and Therapeutics and Department of Medical Genetics, Child and Family Research Institute, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.3233/JHD-140010DOI Listing
October 2014

We are pleased to introduce this next volume of the Journal of Huntington's Disease. Introduction.

J Huntingtons Dis 2013 ;2(1)

University of California, Irvine, CA, USA.

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http://dx.doi.org/10.3233/JHD-130003DOI Listing
September 2014

Correction of inter-scanner and within-subject variance in structural MRI based automated diagnosing.

Neuroimage 2014 Sep 29;98:405-15. Epub 2014 Apr 29.

Freiburg Brain Imaging Center, University Medical Center, University of Freiburg, Freiburg, Germany; Department of Psychiatry and Psychotherapy, University Medical Center Freiburg, Freiburg, Germany; Department of Neurology, University Medical Center Freiburg, Freiburg, Germany.

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http://dx.doi.org/10.1016/j.neuroimage.2014.04.057DOI Listing
September 2014

Diagnostic criteria for Huntington's disease based on natural history.

Mov Disord 2014 Sep 27;29(11):1335-41. Epub 2014 Aug 27.

George-Huntington-Institute, Technology-Park, Muenster, Germany; Department of Neurodegenerative Diseases and Hertie-Institute for Clinical Brain Research, University of Tuebingen, Tuebingen, Germany.

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http://dx.doi.org/10.1002/mds.26011DOI Listing
September 2014

Huntington's disease: a field on the move. Introduction.

Mov Disord 2014 Sep 27;29(11):1333-4. Epub 2014 Aug 27.

George Huntington Institute, Technology Park, Muenster, Germany; Department of Neurodegenerative Diseases and Hertie Institute for Clinical Brain Research, University of Tuebingen, Tuebingen, Germany.

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http://dx.doi.org/10.1002/mds.26017DOI Listing
September 2014

Iron dysregulation in Huntington's disease.

J Neurochem 2014 Aug 28;130(3):328-50. Epub 2014 May 28.

Department of Medical Genetics, Centre for Molecular Medicine & Therapeutics, University of British Columbia and Children's and Women's Hospital, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1111/jnc.12739DOI Listing
August 2014

The catalytic function of hormone-sensitive lipase is essential for fertility in male mice.

Endocrinology 2014 Aug 5;155(8):3047-53. Epub 2014 May 5.

Divisions of Medical Genetics (S.P.W., J.W.W., H.B., S.C., G.A.M.) and Hematology (J.F.L., D.L.), Department of Pediatrics, Centre Hospitalier Universitaire Sainte-Justine and Faculty of Medicine, Université de Montréal, Montréal, Québec, Canada, H3T 1C5; Valeant Cosméderme (H.B.), Laval, Québec, Canada, H7V 0A3; Centre for Molecular Medicine and Therapeutics (B.R.L.), Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada, V5Z 4H4; Department of Pediatrics (J.T.), Human Genetics and Pharmacology and Therapeutics, McGill University and Research Institute of the McGill University Health Centre at the Montreal Children's Hospital, Montréal, Québec, Canada, H3H 1P3; and Department of Anatomy and Cell Biology (C.E.S., L.H.), McGill University, Montréal, Québec, Canada, H3A 2B2.

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http://dx.doi.org/10.1210/en.2014-1031DOI Listing
August 2014

Postnatal muscle modification by myogenic factors modulates neuropathology and survival in an ALS mouse model.

Nat Commun 2013 ;4:2906

1] Department of Medical Genetics, Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada V5Z 4H4 [2] Division of Neurology, Department of Medicine, Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada V5Z 4H4.

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http://dx.doi.org/10.1038/ncomms3906DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4965267PMC
July 2014

Progranulin in neurodegenerative disease.

Trends Neurosci 2014 Jul 4;37(7):388-98. Epub 2014 May 4.

Centre for Molecular Medicine and Therapeutics, Department of Medical Genetics, University of British Columbia, and Children's and Women's Hospital, 980 West 28th Avenue, Vancouver, BC, Canada V5Z 4H4; Division of Neurology, Department of Medicine, University of British Columbia Hospital, S 192, 2211 Wesbrook Mall, Vancouver, BC, Canada V6T 2B5; Brain Research Centre, University of British Columbia, Vancouver, BC V6T 1Z3, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.tins.2014.04.003DOI Listing
July 2014

Clinical utility gene card for: Huntington's disease.

Eur J Hum Genet 2014 May 9;22(5). Epub 2013 Oct 9.

Department of Human Genetics, Huntington Centre NRW, Ruhr-University Bochum, Germany.

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http://dx.doi.org/10.1038/ejhg.2013.206DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3992568PMC
May 2014

p53 increases caspase-6 expression and activation in muscle tissue expressing mutant huntingtin.

Hum Mol Genet 2014 Feb 18;23(3):717-29. Epub 2013 Sep 18.

Centre for Molecular Medicine and Therapeutics (CMMT), Department of Medical Genetics, CFRI, University of British Columbia, 950 West 28th Avenue, Vancouver, BC V5Z 4H4, Canada.

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http://dx.doi.org/10.1093/hmg/ddt458DOI Listing
February 2014

Age-dependent alterations of the kynurenine pathway in the YAC128 mouse model of Huntington disease.

J Neurochem 2013 Dec 15;127(6):852-67. Epub 2013 Jul 15.

Centre for Molecular Medicine & Therapeutics and Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1111/jnc.12350DOI Listing
December 2013

A systematic review and meta-analysis of clinical variables used in Huntington disease research.

Mov Disord 2013 Dec 18;28(14):1987-94. Epub 2013 Oct 18.

Center for Molecular Medicine and Therapeutics and Department of Medical Genetics, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada.

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http://doi.wiley.com/10.1002/mds.25663
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http://dx.doi.org/10.1002/mds.25663DOI Listing
December 2013

Sensitivity to neurotoxic stress is not increased in progranulin-deficient mice.

Neurobiol Aging 2013 Nov 21;34(11):2548-50. Epub 2013 May 21.

Centre for Molecular Medicine & Therapeutics, Department of Medical Genetics, University of British Columbia, and Children's and Women's Hospital, 980 West 28th Avenue, Vancouver, BC, Canada V5Z 4H4.

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http://dx.doi.org/10.1016/j.neurobiolaging.2013.04.019DOI Listing
November 2013

Progranulin promotes activation of microglia/macrophage after pilocarpine-induced status epilepticus.

Brain Res 2013 Sep 22;1530:54-65. Epub 2013 Jul 22.

Brain Research Centre, University of British Columbia, 2211 Wesbrook Mall, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1016/j.brainres.2013.07.023DOI Listing
September 2013

8OHdG as a marker for Huntington disease progression.

Neurobiol Dis 2012 Jun 5;46(3):625-34. Epub 2012 Mar 5.

Department of Psychiatry, The University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S09699961120006
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http://dx.doi.org/10.1016/j.nbd.2012.02.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3784019PMC
June 2012

Synaptic dysfunction in progranulin-deficient mice.

Neurobiol Dis 2012 Feb 25;45(2):711-22. Epub 2011 Oct 25.

Centre for Molecular Medicine & Therapeutics, Department of Medical Genetics, University of British Columbia, and Children's and Women's Hospital, 980 West 28th Avenue, Vancouver, BC, Canada V5Z 4H4.

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http://dx.doi.org/10.1016/j.nbd.2011.10.016DOI Listing
February 2012

Age-dependent neurovascular abnormalities and altered microglial morphology in the YAC128 mouse model of Huntington disease.

Neurobiol Dis 2012 Jan 13;45(1):438-49. Epub 2011 Sep 13.

Centre for Molecular Medicine and Therapeutics and Department of Medical Genetics, Child and Family Research Institute, University of British Columbia, Vancouver, BC, Canada V5Z 4H4.

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http://dx.doi.org/10.1016/j.nbd.2011.09.003DOI Listing
January 2012

Cystamine and ethyl-eicosapentaenoic acid treatment fail to prevent malonate-induced striatal toxicity in mice.

Neurobiol Aging 2011 Dec 7;32(12):2326.e1-4. Epub 2011 Jul 7.

Department of Medical Genetics and Centre for Molecular Medicine and Therapeutics, University of British Columbia, British Columbia, Vancouver, Canada.

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http://dx.doi.org/10.1016/j.neurobiolaging.2011.05.020DOI Listing
December 2011

The structural involvement of the cingulate cortex in premanifest and early Huntington's disease.

Mov Disord 2011 Aug 6;26(9):1684-90. Epub 2011 May 6.

Department of Neurodegenerative Disease, UCL Institute of Neurology, University College London, London, United Kingdom.

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http://dx.doi.org/10.1002/mds.23747DOI Listing
August 2011

Development of biomarkers for Huntington's disease.

Lancet Neurol 2011 Jun;10(6):573-90

Department of Medical Genetics, Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.1016/S1474-4422(11)70070-9DOI Listing
June 2011