Bissan Al-Lazikani

Bissan Al-Lazikani

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Bissan Al-Lazikani

Bissan Al-Lazikani

Publications by authors named "Bissan Al-Lazikani"

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Transforming cancer drug discovery with Big Data and AI.

Expert Opin Drug Discov 2019 Nov 8;14(11):1089-1095. Epub 2019 Jul 8.

The Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research , London , UK.

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https://www.tandfonline.com/doi/full/10.1080/17460441.2019.1
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http://dx.doi.org/10.1080/17460441.2019.1637414DOI Listing
November 2019

Public resources for chemical probes: the journey so far and the road ahead.

Future Med Chem 2019 Nov 28. Epub 2019 Nov 28.

The Department of Data Science, The Institute of Cancer Research, London SM2 5NG, UK.

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http://dx.doi.org/10.4155/fmc-2019-0231DOI Listing
November 2019

Leveraging Human Genetics to Guide Cancer Drug Development.

JCO Clin Cancer Inform 2018 12;2:1-11

All authors: The Institute of Cancer Research, London, United Kingdom.

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http://dx.doi.org/10.1200/CCI.18.00077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6874034PMC
December 2018

Genomics, bio specimens, and other biological data: Current status and future directions.

Med Phys 2018 Oct 18;45(10):e829-e833. Epub 2018 Sep 18.

Department of Radiation Oncology, University of Michigan Health System, Ann Arbor, MI, 48109, USA.

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http://doi.wiley.com/10.1002/mp.12912
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http://dx.doi.org/10.1002/mp.12912DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6214357PMC
October 2018

Sequencing of prostate cancers identifies new cancer genes, routes of progression and drug targets.

Nat Genet 2018 05 16;50(5):682-692. Epub 2018 Apr 16.

The Institute of Cancer Research, London, UK.

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http://www.nature.com/articles/s41588-018-0086-z
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http://dx.doi.org/10.1038/s41588-018-0086-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372064PMC
May 2018

Objective, Quantitative, Data-Driven Assessment of Chemical Probes.

Cell Chem Biol 2018 02 14;25(2):194-205.e5. Epub 2017 Dec 14.

Cancer Research UK Cancer Therapeutics Unit, Division of Cancer Therapeutics, The Institute of Cancer Research, 15 Cotswold Road, London SM2 5NG, UK; Department of Data Science, The Institute of Cancer Research, 15 Cotswold Road, London SM2 5NG, UK. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2017.11.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5814752PMC
February 2018

Polypharmacology in Precision Oncology: Current Applications and Future Prospects.

Curr Pharm Des 2016 ;22(46):6935-6945

Division of Cancer Therapeutics, The Institute of Cancer Research, London, United Kingdom.

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http://www.eurekaselect.com/openurl/content.php?genre=articl
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http://dx.doi.org/10.2174/1381612822666160923115828DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5403974PMC
January 2018

SiGNet: A signaling network data simulator to enable signaling network inference.

PLoS One 2017 17;12(5):e0177701. Epub 2017 May 17.

Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, London, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0177701PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5435248PMC
September 2017

Rational design of non-resistant targeted cancer therapies.

Sci Rep 2017 04 24;7:46632. Epub 2017 Apr 24.

CNAG-CRG, Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology (BIST), Baldiri i Reixac 4, 08028 Barcelona, Spain.

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http://dx.doi.org/10.1038/srep46632DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5402386PMC
April 2017

A comprehensive map of molecular drug targets.

Nat Rev Drug Discov 2017 01 2;16(1):19-34. Epub 2016 Dec 2.

European Molecular Biology Laboratory-European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK.

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http://dx.doi.org/10.1038/nrd.2016.230DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314433PMC
January 2017

Drug discovery in advanced prostate cancer: translating biology into therapy.

Nat Rev Drug Discov 2016 10 22;15(10):699-718. Epub 2016 Jul 22.

The Institute of Cancer Research, 15 Cotswold Road, London SM2 5NG, UK.

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http://dx.doi.org/10.1038/nrd.2016.120DOI Listing
October 2016

Minimizing bias in target selection by exploiting multidisciplinary Big Data and the protein interactome.

Future Med Chem 2016 09 1;8(14):1711-6. Epub 2016 Sep 1.

Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, London, SM2 5NG, UK.

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http://dx.doi.org/10.4155/fmc-2016-0133DOI Listing
September 2016

canSAR: an updated cancer research and drug discovery knowledgebase.

Nucleic Acids Res 2016 Jan 15;44(D1):D938-43. Epub 2015 Dec 15.

Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, London, SM2 5NG, UK

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http://dx.doi.org/10.1093/nar/gkv1030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4702774PMC
January 2016

Blocking the survival of the nastiest by HSP90 inhibition.

Oncotarget 2016 Jan;7(4):3658-61

Cancer Research UK Cancer Therapeutics Unit, Division of Cancer Therapeutics, The Institute of Cancer Research, London, UK.

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http://dx.doi.org/10.18632/oncotarget.6971DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826159PMC
January 2016

Distinctive Behaviors of Druggable Proteins in Cellular Networks.

PLoS Comput Biol 2015 Dec 23;11(12):e1004597. Epub 2015 Dec 23.

Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, London, United Kingdom.

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http://dx.doi.org/10.1371/journal.pcbi.1004597DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4689399PMC
December 2015

Therapeutic opportunities within the DNA damage response.

Nat Rev Cancer 2015 Mar;15(3):166-80

1] Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, London SM2 5NG, UK. [2] Translational Drug Discovery Group, School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QJ, UK.

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http://dx.doi.org/10.1038/nrc3891DOI Listing
March 2015

canSAR: updated cancer research and drug discovery knowledgebase.

Nucleic Acids Res 2014 Jan 3;42(Database issue):D1040-7. Epub 2013 Dec 3.

Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, London, SM2 5NG, UK.

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http://dx.doi.org/10.1093/nar/gkt1182DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3964944PMC
January 2014

Drugging cancer genomes.

Nat Rev Drug Discov 2013 12;12(12):889-90

Cancer Research UK Cancer Therapeutics Unit, Division of Cancer Therapeutics, The Institute of Cancer Research, London SM2 5NG, UK.

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http://dx.doi.org/10.1038/nrd4184DOI Listing
December 2013

Genome-based cancer therapeutics: targets, kinase drug resistance and future strategies for precision oncology.

Curr Opin Pharmacol 2013 Aug 28;13(4):486-96. Epub 2013 Jun 28.

Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, London, SM2 5NG, UK.

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https://linkinghub.elsevier.com/retrieve/pii/S14714892130010
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http://dx.doi.org/10.1016/j.coph.2013.06.004DOI Listing
August 2013

A novel serum protein signature associated with resistance to epidermal growth factor receptor tyrosine kinase inhibitors in head and neck squamous cell carcinoma.

Eur J Cancer 2013 Jul 10;49(11):2512-21. Epub 2013 Apr 10.

Tumour Biology & Metastasis Team, Division of Cancer Therapeutics, The Institute of Cancer Research, Sutton, Surrey SM2 5NG, UK; Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, Sutton, Surrey SM2 5NG, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2013.03.011DOI Listing
July 2013

Objective assessment of cancer genes for drug discovery.

Nat Rev Drug Discov 2013 01;12(1):35-50

Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, London, UK.

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http://dx.doi.org/10.1038/nrd3913DOI Listing
January 2013

Unpicking the combination lock for mutant BRAF and RAS melanomas.

Cancer Discov 2013 Jan;3(1):14-9

Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, London, United Kingdom.

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http://dx.doi.org/10.1158/2159-8290.CD-12-0520DOI Listing
January 2013

Combinatorial drug therapy for cancer in the post-genomic era.

Nat Biotechnol 2012 Jul 10;30(7):679-92. Epub 2012 Jul 10.

Cancer Research UK Cancer Therapeutics Unit, Division of Cancer Therapeutics, The Institute of Cancer Research, Haddow Laboratories, Sutton, UK.

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http://dx.doi.org/10.1038/nbt.2284DOI Listing
July 2012

Personalized medicine: patient-predictive panel power.

Cancer Cell 2012 Apr;21(4):455-8

Signal Transduction and Molecular Pharmacology Team, Cancer Research UK Cancer Therapeutics Unit, Division of Cancer Therapeutics, The Institute of Cancer Research, Haddow Laboratories, Sutton, UK.

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http://dx.doi.org/10.1016/j.ccr.2012.03.030DOI Listing
April 2012

ChEMBL: a large-scale bioactivity database for drug discovery.

Nucleic Acids Res 2012 Jan 23;40(Database issue):D1100-7. Epub 2011 Sep 23.

EMBL-European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK.

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https://academic.oup.com/nar/article-lookup/doi/10.1093/nar/
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http://dx.doi.org/10.1093/nar/gkr777DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3245175PMC
January 2012

canSAR: an integrated cancer public translational research and drug discovery resource.

Nucleic Acids Res 2012 Jan 19;40(Database issue):D947-56. Epub 2011 Oct 19.

Cancer Research UK Cancer Therapeutics Unit, Institute of Cancer Research, Haddow Laboratories, Belmont, Surrey SM2 5NG, UK.

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http://dx.doi.org/10.1093/nar/gkr881DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3245005PMC
January 2012

Collation and data-mining of literature bioactivity data for drug discovery.

Biochem Soc Trans 2011 Oct;39(5):1365-70

Computational Chemical Biology, EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK.

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http://dx.doi.org/10.1042/BST0391365DOI Listing
October 2011

Ligand efficiency indices for an effective mapping of chemico-biological space: the concept of an atlas-like representation.

Drug Discov Today 2010 Oct 19;15(19-20):804-11. Epub 2010 Aug 19.

Center for Pharmaceutical Biotechnology, University of Illinois at Chicago, 60607, USA.

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http://dx.doi.org/10.1016/j.drudis.2010.08.004DOI Listing
October 2010

Protein structure prediction.

Methods Mol Biol 2008 ;453:33-85

Biofocus DPI, London, United Kingdom.

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http://dx.doi.org/10.1007/978-1-60327-429-6_2DOI Listing
October 2008

How many drug targets are there?

Nat Rev Drug Discov 2006 Dec;5(12):993-6

Inpharmatica Ltd., 1 New Oxford Street, London, WC1A 1NU, UK.

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http://www.nature.com/articles/nrd2199
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http://dx.doi.org/10.1038/nrd2199DOI Listing
December 2006

Effective function annotation through catalytic residue conservation.

Proc Natl Acad Sci U S A 2005 Aug 21;102(35):12299-304. Epub 2005 Jul 21.

Inpharmatica, 60 Charlotte Street, London W1T 2NU, United Kingdom.

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http://dx.doi.org/10.1073/pnas.0504833102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1178014PMC
August 2005

The complement of enzymatic sets in different species.

J Mol Biol 2005 Jun;349(4):745-63

EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.

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http://dx.doi.org/10.1016/j.jmb.2005.04.027DOI Listing
June 2005

SCOPEC: a database of protein catalytic domains.

Bioinformatics 2004 Aug;20 Suppl 1:i130-6

Inpharmatica Ltd, London, UK.

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http://dx.doi.org/10.1093/bioinformatics/bth948DOI Listing
August 2004

Sequence, structure and energetic determinants of phosphopeptide selectivity of SH2 domains.

J Mol Biol 2003 Dec;334(4):823-41

Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University, 630 West 168th Street, New York, NY 10032, USA.

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http://dx.doi.org/10.1016/j.jmb.2003.09.075DOI Listing
December 2003