Biruk Tesfaye Birhanu, DVM, MSc, Ph.D. - Addis Ababa University - Assistant Professor

Biruk Tesfaye Birhanu

DVM, MSc, Ph.D.

Addis Ababa University

Assistant Professor

Addis Ababa | Ethiopia

Main Specialties: Infectious Disease, Medical Microbiology, Pharmacology, Radiology-Diagnostic

Additional Specialties: Veterinary Microbiology, Pharmacology

ORCID logohttps://orcid.org/0000-0002-5261-8406


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Biruk Tesfaye Birhanu, DVM, MSc, Ph.D. - Addis Ababa University - Assistant Professor

Biruk Tesfaye Birhanu

DVM, MSc, Ph.D.

Introduction

I obtained my DVM and MSc degrees from Addis Ababa University, Ethiopia in 2007 and 2011, respectively. My MSc major is veterinary Microbiology. I also obtained my Ph.D. in Veterinary Medicine, major Pharmacology, from Kyungpook National University in August 2018. Currently, I am working as a Postdoctoral Researcher at Kyungpook National University.

During my graduate program, I have published more than 15 publications as the first author and co-author of scientific journals and participated in various projects related to both basic sciences and technology studies. The focus of my studies was to develop a novel drug candidate that inhibit bacterial survival mechanism, bacterial resistance against antibiotics, microbial pathogenesis (including quorum-sensing) and bacterial essential metabolic pathways through molecular, genomics/proteomics and pharmacological approach (including pharmacokinetics-pharmacodynamics interaction).

My research ability has advanced during my Ph.D. study period and when I worked as an assistant professor at Addis Ababa University. I have experience of teaching in higher education and advising students for their research/thesis. I have developed and run projects on bacterial agents related to the respiratory system, mastitis, and diarrhea in domestic animals. The study includes; (1) Optimizing antibiotics to restrict bacterial resistance (zoonotic pathogen, Salmonella Typhimurium) (2) Identifying potential drug targets by using genomics/proteomics approach in Actinobacillus spp, (3) Quorum-sensing inhibitors against Salmonella and (4) inhibitory activity of compounds against bacterial adhesion, invasion and intracellular survival (5) chemicals and drug analysis based on their pharmacokinetics and pharmacodynamic activity. These researches further heighten my interest in studying host-pathogen interaction and drug-resistant microbes.

My research target is to study bacterial interaction, quorum sensing signaling, pathogenetic mechanisms, drug metabolism, and develop novel anti-microbial agents against bacteria that acquire antibiotic resistance genes and have an antibiotic avoidance mechanism in host cells which could be also expanded into microbiota and host interaction. In addition, I am interested in cell signaling mechanism and immune responses to infectious agents. Considering this, therefore, I would very much like to learn more of and pursue my intensive study in research institutes or universities. I believe that my diverse experience in different research activities (from molecular works to animal experiments), excellent techniques with skills and strong willpower will be suitable for various research field and also the experience in others group will be able to provide necessary opportunities for my research careers.

Primary Affiliation: Addis Ababa University - Addis Ababa , Ethiopia

Specialties:

Additional Specialties:

Research Interests:


View Biruk Tesfaye Birhanu’s Resume / CV

Education

Mar 2015 - Aug 2018
Kyungpook National University
Ph.D.
Veterinary Medicine
Sep 2000 - Jul 2011
Addis Ababa University
MSc. Microbiology
Microbiology, Immunology and Veterinary Public Health
Sep 2000 - Aug 2007
Addis Ababa University
Doctor of Veterinary Medicine
Microbiology, Immunology and Veterinary Public Health

Experience

Sep 2019
Kyungpook National University
Postdoctoral Researcher
Cardiovascular Research Institute
Sep 2018 - Sep 2018
Chonnam National University Medical School
Postdoctoral Researcher
Radioloy
Feb 2012 - Feb 2012
Addis Ababa University
Assistant Profesor
Microbiology, Immunology and Veterinary Public Health
Aug 2011 - Jan 2012
Haramaya University
Assistant professor
Veterinary Medicicne

Publications

18Publications

275Reads

70Profile Views

1PubMed Central Citations

Evaluation of the pharmacokinetic-pharmacodynamic integration of marbofloxacin in combination with methyl gallate against Salmonella Typhimurium in rats.

PLoS One 2020 4;15(6):e0234211. Epub 2020 Jun 4.

Laboratory of Veterinary Pharmacokinetics and Pharmacodynamics, College of Veterinary Medicine, Kyungpook National University, Bukgu, Daegu, South Korea.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0234211PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7272065PMC
June 2020
3.234 Impact Factor

Inhibition of Salmonella Typhimurium adhesion, invasion, and intracellular survival via treatment with methyl gallate alone and in combination with marbofloxacin.

Vet Res 2018 Oct 4;49(1):101. Epub 2018 Oct 4.

Laboratory of Veterinary Pharmacokinetics and Pharmacodynamics, College of Veterinary Medicine, Kyungpook National University, Bukgu, Daegu, 41566, South Korea.

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http://dx.doi.org/10.1186/s13567-018-0597-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389159PMC
October 2018
246 Reads
2.820 Impact Factor

An in vivo immunomodulatory and anti-inflammatory study of fermented Dendropanax morbifera Léveille leaf extract.

BMC Complement Altern Med 2018 Jul 24;18(1):222. Epub 2018 Jul 24.

Laboratory of Veterinary Pharmacokinetics and Pharmacodynamics, College of Veterinary Medicine, Kyungpook National University, Bukgu, 80 Daehakro, Daegu, 41566, South Korea.

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http://dx.doi.org/10.1186/s12906-018-2282-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6057031PMC
July 2018
13 Reads
2.020 Impact Factor

Enhancement of Lipid Metabolism and Hepatic Stability in Fat-Induced Obese Mice by Fermented Extract.

Evid Based Complement Alternat Med 2018 13;2018:3908453. Epub 2018 Mar 13.

College of Veterinary Medicine, Kyungpook National University, Daegu 702-701, Republic of Korea.

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http://dx.doi.org/10.1155/2018/3908453DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5872621PMC
March 2018
9 Reads
1 Citation
1.880 Impact Factor

Investigation of Marek's disease virus from chickens in central Ethiopia.

Trop Anim Health Prod 2017 Feb 14;49(2):403-408. Epub 2016 Dec 14.

Research and Development Department, National Veterinary Institute (NVI), P.O. Box 19, Debre zeit, Ethiopia.

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http://dx.doi.org/10.1007/s11250-016-1208-1DOI Listing
February 2017
7 Reads
0.820 Impact Factor

Isolation, identification and drug resistance patterns of methicillin resistant Staphylococcus aureus from mastitic cow’s milk from selected dairy farms in and around Kombolcha, Ethiopia

Journal of Veterinary Medicine and Animal Health

A cross sectional study was conducted between January and May 2015 in and around Kombolcha town, Eastern Amhara, to identify methicillin resistant Staphylococcus aureus and their resistance to antimicrobials and also to identify risk factors associated with the occurrence of dairy cow mastitis. A total of 150 dairy cows were included during the study period. A total of 600 quarters were examined to detect clinical and subclinical mastitis by physical examinations of udder and milk and California mastitis test, respectively. The prevalence of mastitis was 56%. Age, milking hygiene, parity, and floor system had significant (p<0.05) effect on the prevalence of mastitis. S. aureus was isolated at a rate of 11 (73.3%) and 29 (42%) in clinical and subclinical mastitis, respectively. The result showed the occurrence of S. aureus in clinical mastitis was found to be significantly higher than subclinical mastitis (p=0.028). The present study showed that S. aureus was resistant to penicillin G (100%), amoxicillin (100%), cefoxitin (42.7%) and tetracycline (77.4%) however all the isolates were found to be totally (100%) susceptible to the gentamycin. 45.3% of the isolates were found to be multidrug resistant. Antimicrobial resistance is due to repeated therapeutic use of drugs. Regular antimicrobial sensitivity testing helps to select effective antibiotics that ultimately reduce the development of resistance towards commonly used antibiotics. In conclusion, Mastitis caused by S. aureus is one of the major problems of dairy cows in milk production in the study area.

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January 2016
10 Reads

Isolation and phenotypic characterization of Streptococcus uberis from mastitic cows in and around Batu town, Ethiopia.

Journal of Animal &Plant Sciences

Streptococcus uberis have emerged to be pathogens causing intramammary infections in dairy herds. In Ethiopia, knowledge about the Streptococcus uberis (S.uberis) involved in mastitis is limited. A cross-sectional study was carried out in Batu East shoa Zone of Oromia State, Ethiopia from December 2014 to April 2015 with the aim of isolation and phenotypic characterization of Streptococcus uberis from bovine mastitis. A total of 230 lactating (Holstein (n=115), Borena (68) and Jersey (n=71)) cows were included in this study and out of those, 97 (42.2%) were found to be affected with mastitis infection which was detected by clinical examination and the California Mastitis Test (CMT), of which 16(7%) and 81(35.2%) had clinical and subclinical mastitis, respectively. Positive milk samples were used for bacteriological examination and a total of 18 isolate of S. uberis were obtained. In the present study out of seven in vitro antimicrobial used, Nalidixic acid (37.5%), Amoxicillin (25%), Streptomycin (25%), Oxytetracycline (25%), Kanamycin (18.75%), Ceftriaxone (18.75%), and Compound sulphonamide (12.5%) showed resistance to S. uberis. Among the potential risk factors considered, age, parity, stage of lactation, breed and floor type were found to affect the occurrence of S. uberis mastitis significantly (P<0.05). In this study, it is observed that S. uberis should be given a great concern as a threat for the dairy industries.

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October 2015
11 Reads

Top co-authors

Md Akil Hossain
Md Akil Hossain

Kyungpook National University

3
Biruk Tesfaye
Biruk Tesfaye

Addis Ababa University

1
Shiferaw Jenberie
Shiferaw Jenberie

National Veterinary Institute

1
Gelagay Ayelet
Gelagay Ayelet

National Veterinary Institute

1
Esayas Gelaye
Esayas Gelaye

National Veterinary Institute

1
Berhan Demeke
Berhan Demeke

National Veterinary Institute (NVI)

1