Publications

The Apolipoprotein M/S1P Axis Controls Triglyceride Metabolism and Brown Fat Activity.
Cell Rep 2018 Jan;22(1):175-188
Department of Clinical Biochemistry, Rigshospitalet, 2100 Copenhagen, Denmark; Department of Biomedical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark; Department of Clinical Medicine, University of Copenhagen, 2200 Copenhagen, Denmark. Electronic address:

Development of potent and proteolytically stable human neuromedin U receptor agonists.
Eur J Med Chem 2018 Jan 14;144:887-897. Epub 2017 Dec 14.
Research Group of Organic Chemistry, Departments of Chemistry and Bioengineering Sciences, Vrije Universiteit Brussel, Pleinlaan 2, 1050, Brussels, Belgium. Electronic address:


Model-Based Discovery of Synthetic Agonists for the Zn-Sensing G-Protein-Coupled Receptor 39 (GPR39) Reveals Novel Biological Functions.
J Med Chem 2017 Feb 23;60(3):886-898. Epub 2017 Jan 23.
Novo Nordisk Foundation Center for Protein Research, University of Copenhagen , Blegdamsvej 3, DK-2200, Copenhagen, Denmark.

GPR119, a Major Enteroendocrine Sensor of Dietary Triglyceride Metabolites Coacting in Synergy With FFA1 (GPR40).
Endocrinology 2016 Dec 25;157(12):4561-4569. Epub 2016 Oct 25.
NNF Center for Basic Metabolic Research (J.H.E., M.H., L.V.K., A.N.M., M.S.E., A.-S.H., R.S., K.L.E., B.H., T.W.S.), Section for Metabolic Receptology; Laboratory for Molecular Pharmacology (J.H.E., M.H., L.V.K., M.S.E., A.-S.H., R.S., K.L.E., B.H., T.W.S.), Department of Neuroscience and Pharmacology; and Danish Diabetes Academy (M.S.E.), 5000 Odense, Denmark; Novo Nordisk Foundation Center for Basic Metabolic Research (P.T.), Section for Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2200 Copenhagen, Denmark; Merck Research Laboratories (T.J.K., A.D.H.), Kenilworth, New Jersey 07033; Cambridge Institute for Medical Research and MRC Metabolic Diseases Unit (F.M.G., F.R.), University of Cambridge, Cambridge, CB20QQ United Kingdom; Department of Drug Design and Pharmacology (H.S.H.), University of Copenhagen, DK-2100 Copenhagen, Denmark.

Acute disruption of glucagon secretion or action does not improve glucose tolerance in an insulin-deficient mouse model of diabetes.
Diabetologia 2016 Feb 5;59(2):363-70. Epub 2015 Nov 5.
Section for Translational Metabolic Physiology, Novo Nordisk Foundation Center for Basic Metabolic Research and Department of Biomedical Sciences, University of Copenhagen, Blegdamsvej 3, building 12.2, DK-2200, Copenhagen, Denmark.

FGF21 Mediates Endocrine Control of Simple Sugar Intake and Sweet Taste Preference by the Liver.
Cell Metab 2016 Feb 24;23(2):335-43. Epub 2015 Dec 24.
Department of Pharmacology, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA; Fraternal Order of Eagles Diabetes Research Center, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA. Electronic address:

Immune malfunction in the GPR39 zinc receptor of knockout mice: Its relationship to depressive disorder.
J Neuroimmunol 2016 Feb 2;291:11-7. Epub 2015 Dec 2.
Department of Pharmacobiology, Jagiellonian University Medical College, Medyczna 9, PL 30-688 Kraków, Poland; Institute of Pharmacology, Polish Academy of Sciences, Smętna 12, PeL 31-343 Kraków, Poland.

Neurotensin Is Coexpressed, Coreleased, and Acts Together With GLP-1 and PYY in Enteroendocrine Control of Metabolism.
Endocrinology 2016 Jan 15;157(1):176-94. Epub 2015 Oct 15.
Novo Nordisk Foundation Center for Basic Metabolic Research (K.V.G., C.F.R., B.S., M.S.E., A.N.M., J.P., M.K.N., K.L.E., F.B., J.J.H., B.H., T.W.S.), Section for Metabolic Receptology and Enteroendocrinology; Laboratory for Molecular Pharmacology (K.V.G., C.F.R., M.S.E., A.N.M., M.K.N., K.L.E., B.H., T.W.S.), Department of Neuroscience and Pharmacology; and Department of Biomedical Sciences (B.S., J.P., S.S.P., J.J.H.), Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen DK-2200, Denmark; Department of Molecular and Clinical Medicine (F.S., F.B.), Sahlgrenska Center for Cardiovascular and Metabolic Research/Wallenberg Laboratory, University of Gothenburg, 413 45 Gothenburg, Sweden; Danish Diabetes Academy (M.S.E.), 5000 Odense, Denmark; Merck Research Laboratories (A.R.N., T.K., A.D.H.), Kenilworth, NJ 07033; and Department of Pharmacology (S.O.), Max-Planck-Institute for Heart and Lung Research, 61231 Bad Nauheim, Germany.

In Silico Investigation of the Neurotensin Receptor 1 Binding Site: Overlapping Binding Modes for Small Molecule Antagonists and the Endogenous Peptide Agonist.
Mol Inform 2016 Jan 16;35(1):19-24. Epub 2015 Sep 16.
M Lückmann, B Holst, TW Schwartz, TM Frimurer, Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen. Denmark.

Bioorthogonal Labeling of Ghrelin Receptor to Facilitate Studies of Ligand-Dependent Conformational Dynamics.
Chem Biol 2015 Nov 5;22(11):1431-1436. Epub 2015 Nov 5.
Laboratory of Chemical Biology and Signal Transduction, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA; Department of Neurobiology, Care Sciences and Society, Division for Neurogeriatrics, Center for Alzheimer Research, Karolinska Institutet, 141 57 Huddinge, Sweden. Electronic address:

Impaired oxidative capacity due to decreased CPT1b levels as a contributing factor to fat accumulation in obesity.
Am J Physiol Regul Integr Comp Physiol 2015 Jun 8;308(11):R973-82. Epub 2015 Apr 8.
Laboratory for Molecular Pharmacology, Department of Neuroscience and Pharmacology, University of Copenhagen, Copenhagen, Denmark; Section for Metabolic Receptology and Enteroendocrinology, The Novo Nordisk Foundation Center for basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark;

Synthesis and evaluation of novel lipidated neuromedin U analogs with increased stability and effects on food intake.
J Pept Sci 2015 Feb 17;21(2):85-94. Epub 2014 Dec 17.
Gubra ApS, Agern Alle 1, 2970, Hørsholm, Denmark; The Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Blegdamsvej 3B, 2200, Copenhagen N, Denmark.

GPR40 (FFAR1) - Combined Gs and Gq signaling in vitro is associated with robust incretin secretagogue action ex vivo and in vivo.
Mol Metab 2015 Jan 24;4(1):3-14. Epub 2014 Oct 24.
Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, 2200 Copenhagen N, Denmark ; Department of Neuroscience and Pharmacology, University of Copenhagen, DK-2200, Copenhagen, Denmark.

The melanocortin-4 receptor is expressed in enteroendocrine L cells and regulates the release of peptide YY and glucagon-like peptide 1 in vivo.
Cell Metab 2014 Dec 20;20(6):1018-29. Epub 2014 Nov 20.
Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA. Electronic address:

GPR39 (zinc receptor) knockout mice exhibit depression-like behavior and CREB/BDNF down-regulation in the hippocampus.
Int J Neuropsychopharmacol 2014 Oct 31;18(3). Epub 2014 Oct 31.
Department of Biochemical Toxicology, Jagiellonian University Medical College, Medyczna 9, PL 30-688 Kraków, Poland (Dr. K. Młyniec, Prof. B. Budziszewska); Institute of Pharmacology, Polish Academy of Sciences, Smętna 12, PL 31-343 Kraków, Poland (Profs. B. Budziszewska, G. Nowak); Department of Neuroscience and Pharmacology University of Copenhagen, Blegdamsvej 3, DK-2200, Copenhagen, Denmark (Prof. B. Holst); Faculty of Physics and Applied Computer Science, AGH University of Science and Technology, Kraków, Poland (Dr. B. Ostachowicz); Department of Pharmacobiology, Jagiellonian University Medical College, Medyczna 9, PL 30-688 Kraków, Poland (Prof. G. Nowak).



Improving membrane binding as a design strategy for amphipathic peptide hormones: 2-helix variants of PYY3-36.
J Pept Sci 2012 Sep 1;18(9):579-87. Epub 2012 Aug 1.
Department of Chemistry, Faculty of Science, University of Copenhagen, Thorvaldsensvej 40, 1871, Frederiksberg C, Denmark.

Deficiency of the GPR39 receptor is associated with obesity and altered adipocyte metabolism.
FASEB J 2011 Nov 22;25(11):3803-14. Epub 2011 Jul 22.
Laboratory for Molecular Pharmacology, Department of Neuroscience and Pharmacology, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.

Studies on the anorectic effect of N-acylphosphatidylethanolamine and phosphatidylethanolamine in mice.
Biochim Biophys Acta 2011 Sep 23;1811(9):508-12. Epub 2011 Jun 23.
Department of Pharmacology & Pharmacotherapy, Faculty of Pharmaceutical Sciences, University of Copenhagen, 2100 Copenhagen, Denmark.

Unique interaction pattern for a functionally biased ghrelin receptor agonist.
J Biol Chem 2011 Jun 14;286(23):20845-60. Epub 2011 Mar 14.
Laboratory for Molecular Pharmacology, Department of Neuroscience and Pharmacology, University of Copenhagen, Blegdamsvej 3b, DK-2200, Copenhagen, Denmark.




Melanocortin 4 receptor mutations in obese Czech children: studies of prevalence, phenotype development, weight reduction response, and functional analysis.
J Clin Endocrinol Metab 2007 Sep 19;92(9):3689-96. Epub 2007 Jun 19.
Department of Pediatrics and Center for Research of Diabetes, Metabolism, and Nutrition, Third Faculty of Medicine, Charles University, 100 34 Prague 10, Czech Republic.

GPR39 splice variants versus antisense gene LYPD1: expression and regulation in gastrointestinal tract, endocrine pancreas, liver, and white adipose tissue.
Mol Endocrinol 2007 Jul 8;21(7):1685-98. Epub 2007 May 8.
Laboratory for Molecular Pharmacology, Department of Neuroscience and Pharmacology, University of Copenhagen, DK-2200 Copenhagen, Denmark.


PICK1 deficiency impairs secretory vesicle biogenesis and leads to growth retardation and decreased glucose tolerance.
PLoS Biol 2013 23;11(4):e1001542. Epub 2013 Apr 23.
Laboratory for Molecular Pharmacology, Novo Nordisk Foundation Center for Basic Metabolic Research, The Faculty of Health Sciences, Panum Institute, University of Copenhagen, Copenhagen, Denmark.

Anxiolytic-Like Effects of Increased Ghrelin Receptor Signaling in the Amygdala.
Int J Neuropsychopharmacol 2016 05 29;19(5). Epub 2016 Apr 29.
Laboratory of Molecular Pharmacology, Department of Neuroscience and Pharmacology, University of Copenhagen, Copenhagen, Denmark, and The Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark (Mr Jensen, Ms Ratner, Dr Rudenko, Ms Skov, Ms Hundahl, and Dr Holst); Laboratory of Neural Plasticity, Department of Neuroscience and Pharmacology, University of Copenhagen, Copenhagen, Denmark (Drs Christiansen and Woldbye).

Functional and genetic epidemiological characterisation of the FFAR4 (GPR120) p.R270H variant in the Danish population.
J Med Genet 2016 09 11;53(9):616-23. Epub 2016 Apr 11.
Section of Metabolic Genetics, The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark.


Effects of Peripheral Neurotensin on Appetite Regulation and Its Role in Gastric Bypass Surgery.
Endocrinology 2016 09 20;157(9):3482-92. Epub 2016 Jul 20.
Laboratory for Molecular Pharmacology (C.R., L.J.S., Z.R., B.S., A.N.M., B.Ho.), Department of Neuroscience and Pharmacology, and Department of Biomedical Sciences (B.Ha., J.J.H.), Faculty of Health Sciences, University of Copenhagen, DK-2200 Copenhagen, Denmark; Section for Metabolic Receptology (C.R., L.J.S., Z.R., B.S., A.N.M., B.Ho.) and Section for Translational Metabolic Physiology (B.Ha., J.J.H.), the Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health Sciences, University of Copenhagen, DK-2200 Copenhagen, Denmark; Institute of Veterinary Physiology (T.B., C.L.F., T.A.L.), Vetsuisse Faculty, and Center for Integrative Human Physiology (T.A.L.), University of Zurich, CH-8057 Zurich, Switzerland; Institute of Biochemistry (K.B.-S., A.G.B.-S.), University of Leipzig, D-04103 Leipzig, Germany; Gubra ApS (L.S.D., J.J.), Hørsholm, DK-2970 Denmark; and Biomedicine Discovery Institute (Z.B.A.), Metabolic Disease and Obesity Program, Monash University, Melbourne, Victoria 3800, Australia.

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