Birgit Geoerger

Birgit Geoerger

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Birgit Geoerger

Birgit Geoerger

Publications by authors named "Birgit Geoerger"

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Newly identified LMO3-BORCS5 fusion oncogene in Ewing sarcoma at relapse is a driver of tumor progression.

Oncogene 2019 Sep 5. Epub 2019 Sep 5.

Laboratoire de Vectorologie et Thérapeutiques Anticancéreuses, Université Paris-Sud 11, CNRS UMR 8203, Gustave Roussy Cancer Center, 94805, Villejuif, France.

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http://dx.doi.org/10.1038/s41388-019-0914-3DOI Listing
September 2019

Sequential or combined designs for Phase I/II clinical trials? A simulation study.

Clin Trials 2019 Sep 20:1740774519872702. Epub 2019 Sep 20.

Biostatistics and Epidemiology Department, Gustave Roussy, Villejuif, France.

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http://dx.doi.org/10.1177/1740774519872702DOI Listing
September 2019

Discovery of New Fusion Transcripts in a Cohort of Pediatric Solid Cancers at Relapse and Relevance for Personalized Medicine.

Mol Ther 2019 01 2;27(1):200-218. Epub 2018 Nov 2.

Université Paris-Sud 11, Laboratoire de Vectorologie et Thérapeutiques Anticancéreuses, UMR 8203, Villejuif 94805, France; CNRS, Villejuif, Laboratoire de Vectorologie et Thérapeutiques Anticancéreuses, UMR 8203, Villejuif 94805, France; Gustave Roussy, Laboratoire de Vectorologie et Thérapeutiques Anticancéreuses, UMR 8203, Villejuif 94805, France. Electronic address:

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http://dx.doi.org/10.1016/j.ymthe.2018.10.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319200PMC
January 2019

Efficacy of nivolumab in a patient with systemic refractory ALK+ anaplastic large cell lymphoma.

Pediatr Blood Cancer 2018 04 28;65(4). Epub 2017 Nov 28.

Department of Oncology for Children and Adolescents, Gustave Roussy Caner Campus, Villejuif, France.

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http://dx.doi.org/10.1002/pbc.26902DOI Listing
April 2018

Outcome of children and adolescents with central nervous system tumors in phase I trials.

J Neurooncol 2018 Mar 13;137(1):83-92. Epub 2017 Dec 13.

Pediatric and Adolescent Drug Development, Children and Young People's Unit, The Royal Marsden NHS Foundation Trust - Paediatric Offices, Downs Road, Sutton, SM2 5PT, UK.

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http://dx.doi.org/10.1007/s11060-017-2698-zDOI Listing
March 2018

Precision medicine in pediatric oncology.

Curr Opin Pediatr 2018 02;30(1):17-24

Pediatrics, Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1097/MOP.0000000000000570DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5770114PMC
February 2018

Revisiting the definition of dose-limiting toxicities in paediatric oncology phase I clinical trials: An analysis from the Innovative Therapies for Children with Cancer Consortium.

Eur J Cancer 2017 11 19;86:275-284. Epub 2017 Oct 19.

Gustave Roussy, Biostatistics and Epidemiology Unit, Villejuif, France; INSERM U1018, CESP, Univ. Paris-Sud, Univ. Paris-Saclay, Villejuif, France. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2017.09.015DOI Listing
November 2017

Phase I study of oral sonidegib (LDE225) in pediatric brain and solid tumors and a phase II study in children and adults with relapsed medulloblastoma.

Neuro Oncol 2017 Oct;19(11):1542-1552

Pediatric Neuro-Oncology, Dana-Farber Boston Children's Cancer Blood Disorders Center, Harvard Medical School, Boston, Massachusetts, USA; The Royal Marsden Hospital, Sutton, Surrey, UK; Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy; Department of Medical Oncology, Azienda USL-IRCCS Institute of Neurological Science, Bologna, Italy; Institut Curie and University Paris Descartes, Paris, France; Division of Haematology/Oncology at The Hospital for Sick Children, Toronto, Ontario, Canada; Sir James Spence Institute of Child Health Royal Victoria Infirmary, Newcastle, UK; Seattle Children's Hospital, University of Washington and Fred Hutchinson Cancer Research Center, Seattle, Washington, USA; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Emory University School of Medicine, Atlanta, Georgia, USA; The Royal Children's Hospital, Children's Cancer Center, Melbourne, Australia; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland, USA; Catholic University of the Sacred Heart, Rome, Italy; Cancer Clinical Research Unit, Princess Margaret Cancer Centre, Toronto, Ontario, Canada; Paediatric Oncology Unit, Great Ormond Street Hospital, London, UK; Novartis Pharmaceuticals Corporation, East Hanover, New Jersey, USA; Gustave Roussy, Department of Pediatric and Adolescent Oncology, University Paris-Sud, Université Paris-Saclay, Villejuif, France.

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http://dx.doi.org/10.1093/neuonc/nox109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5737275PMC
October 2017

Genomic diagnostics leading to the identification of a TFG-ROS1 fusion in a child with possible atypical meningioma.

Cancer Genet 2017 04 22;212-213:32-37. Epub 2017 Mar 22.

Department of Paediatrics and Adolescent Medicine, Neuroscience Center, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.

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http://dx.doi.org/10.1016/j.cancergen.2017.03.005DOI Listing
April 2017

Relevance of Fusion Genes in Pediatric Cancers: Toward Precision Medicine.

Mol Ther Nucleic Acids 2017 Mar 9;6:315-326. Epub 2017 Feb 9.

Vectorology and Anticancer Therapies, UMR 8203 CNRS, University Paris-Sud, Gustave Roussy, Université Paris-Saclay, 94805 Villejuif, France. Electronic address:

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http://dx.doi.org/10.1016/j.omtn.2017.01.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363511PMC
March 2017

Dual inhibition using cabozantinib overcomes HGF/MET signaling mediated resistance to pan-VEGFR inhibition in orthotopic and metastatic neuroblastoma tumors.

Int J Oncol 2017 Jan 6;50(1):203-211. Epub 2016 Dec 6.

Vectorology and Anticancer Therapies, UMR 8203, CNRS, Univ. Paris-Sud, Gustave Roussy, Université Paris-Saclay, Villejuif, France.

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http://dx.doi.org/10.3892/ijo.2016.3792DOI Listing
January 2017

Phase 1 study of dalotuzumab monotherapy and ridaforolimus-dalotuzumab combination therapy in paediatric patients with advanced solid tumours.

Eur J Cancer 2016 07 10;62:9-17. Epub 2016 May 10.

Department of Pediatric and Adolescent Oncology, Gustave Roussy, Univ. Paris-Sud, 114, rue Edouard Vaillant, 94805 Villejuif, France. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2016.03.084DOI Listing
July 2016

Innovations for phase I dose-finding designs in pediatric oncology clinical trials.

Contemp Clin Trials 2016 Mar 26;47:217-27. Epub 2016 Jan 26.

Gustave Roussy, Biostatistics and Epidemiology unit, Villejuif, France; INSERM U1018, CESP, Univ. Paris-Sud, Univ. Paris-Saclay, Villejuif, France.

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http://dx.doi.org/10.1016/j.cct.2016.01.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4818190PMC
March 2016

Polo-like Kinase Inhibitor Volasertib Exhibits Antitumor Activity and Synergy with Vincristine in Pediatric Malignancies.

Anticancer Res 2016 Feb;36(2):599-609

Vectorology and Anticancer Therapies, UMR 8203, CNRS, Paris-Sud University, Gustave Roussy Institute, Paris-Saclay University, Villejuif, France

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February 2016

Phase I study of non-pegylated liposomal doxorubicin in children with recurrent/refractory high-grade glioma.

Cancer Chemother Pharmacol 2015 Aug 27;76(2):425-32. Epub 2015 Jun 27.

Paediatric Oncology Department, Children University Hospital, Allée du Morvan, 54510, Vandœuvre-lès-Nancy Cedex, France,

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http://link.springer.com/10.1007/s00280-015-2781-0
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http://dx.doi.org/10.1007/s00280-015-2781-0DOI Listing
August 2015

Preclinical evaluation of dasatinib alone and in combination with cabozantinib for the treatment of diffuse intrinsic pontine glioma.

Neuro Oncol 2015 Jul 21;17(7):953-64. Epub 2014 Dec 21.

CNRS UMR 8203 Vectorology and Anticancer Therapeutics, Gustave Roussy Cancer Institute, Paris XI University, Villejuif, France (N.T., C.P., F.A., L.G.-R., G.C., L.L.-D., B.G., G.V., J.G.); Functional Genomics Unit, Gustave Roussy Cancer Institute, Paris XI University, Villejuif, France (C.R.); Translational Research Laboratory and Biobank, Gustave Roussy Cancer Institute, Paris XI University, Villejuif, France (L.L.); Inserm U981, Gustave Roussy Cancer Institute, Paris XI University, Villejuif, France (L.L.); Department of Medical Biology and Pathology, Gustave Roussy Cancer Institute, Paris XI University, Villejuif, France (L.L.); Department of Pediatric and Adolescent Oncology, Gustave Roussy Cancer Institute, Paris XI University, Villejuif, France (B.G., J.G.); Department of Oncology and Pathology, Karolinska Institutet, Stockholm, Sweden (J.P., A.Ö.); Department of Neurosurgery, Necker-Sick Children Hospital, Paris Descartes University, Paris, France (S.P.).

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http://dx.doi.org/10.1093/neuonc/nou330DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5654348PMC
July 2015

Patients in pediatric phase I and early phase II clinical oncology trials at Gustave Roussy: a 13-year center experience.

J Pediatr Hematol Oncol 2015 Mar;37(2):e102-10

Departments of *Pediatric and Adolescent Oncology †Biostatistics and Epidemiology ‡Radiology §CNRS UMR 8203 Vectorology and Anticancer Therapeutics, Université Paris-Sud 11, Gustave Roussy, Villejuif, France.

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http://dx.doi.org/10.1097/MPH.0000000000000237DOI Listing
March 2015

Inhibition of the NOTCH pathway using γ-secretase inhibitor RO4929097 has limited antitumor activity in established glial tumors.

Anticancer Drugs 2015 Mar;26(3):272-83

aGustave Roussy, Vectorology and Anticancer Therapeutics, Villejuif bUniversité Paris-Sud cCentre National de Recherche Scientifique (CNRS), Vectorology and Anticancer Therapeutics, UMR 8203, Orsay, France dDepartment of Neurosurgery, Necker Enfants-Malades Hospital, Paris-Descartes University, Paris ePediatric American Memorial Hospital, CHU Reims, Reims, France fHoffmann-La Roche Inc., Nutley, New Jersey, USA.

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http://dx.doi.org/10.1097/CAD.0000000000000190DOI Listing
March 2015

Establishment and characterization of new orthotopic and metastatic neuroblastoma models.

In Vivo 2014 Jul-Aug;28(4):425-34

Vectorology and Anticancer Therapeutics, UMR 8203, University Paris-Sud, Orsay, France CNRS, Orsay, Vectorology and Anticancer Therapeutics, UMR 8203, Orsay, France Gustave Roussy Institute, Vectorology and Anticancer Therapeutics, UMR 8203, Villejuif, France Department of Pediatric and Adolescent Oncology, Gustave Roussy Institute, Villejuif, France

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February 2015

Vemurafenib in pediatric patients with BRAFV600E mutated high-grade gliomas.

Pediatr Blood Cancer 2014 Jun 3;61(6):1101-3. Epub 2013 Dec 3.

Pediatric and Adolescent Oncology Department, Gustave Roussy, Villejuif, France.

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http://dx.doi.org/10.1002/pbc.24891DOI Listing
June 2014

A comparative analysis of paediatric dose-finding trials of molecularly targeted agent with adults' trials.

Eur J Cancer 2013 Jul 27;49(10):2392-402. Epub 2013 Mar 27.

Biostatistics department, Institut Curie, Paris, France.

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http://dx.doi.org/10.1016/j.ejca.2013.02.028DOI Listing
July 2013

Is the European pediatric medicine regulation working for children and adolescents with cancer?

Clin Cancer Res 2013 Mar 17;19(6):1315-25. Epub 2013 Jan 17.

Clinical Research Division, Institut Gustave Roussy, Villejuif Cedex, France.

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http://dx.doi.org/10.1158/1078-0432.CCR-12-2551DOI Listing
March 2013

Everolimus for astrocytomas in tuberous sclerosis complex.

Lancet 2013 Jan 14;381(9861):95-6. Epub 2012 Nov 14.

Institut Gustave Roussy, Paediatrie, CNRS UMR8203, Villejuif 94805, France.

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http://dx.doi.org/10.1016/S0140-6736(12)61221-5DOI Listing
January 2013

Bone sarcomas: from biology to targeted therapies.

Sarcoma 2012 27;2012:301975. Epub 2012 Nov 27.

Department of Oncology for Children and Adolescents, Institut Gustave Roussy, 114 rue Edouard Vaillant, 94805 Villejuif Cedex, France.

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http://dx.doi.org/10.1155/2012/301975DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3514839PMC
December 2012

Targeting the EWSR1-FLI1 oncogene-induced protein kinase PKC-β abolishes ewing sarcoma growth.

Cancer Res 2012 Sep 28;72(17):4494-503. Epub 2012 Aug 28.

Institut Curie, INSERM U830, Unité de Génétique et Biologie des Cancers, Institut Curie, Unité de génétique somatique, Paris, France.

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http://dx.doi.org/10.1158/0008-5472.CAN-12-0371DOI Listing
September 2012

Phase II trial of temsirolimus in children with high-grade glioma, neuroblastoma and rhabdomyosarcoma.

Eur J Cancer 2012 Jan 25;48(2):253-62. Epub 2011 Oct 25.

Institut Gustave Roussy, Department of Paediatric and Adolescent Medicine, University Paris-Sud, Villejuif, France.

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http://dx.doi.org/10.1016/j.ejca.2011.09.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3539305PMC
January 2012

The selective VEGFR1-3 inhibitor axitinib (AG-013736) shows antitumor activity in human neuroblastoma xenografts.

Int J Cancer 2011 Jun 8;128(11):2748-58. Epub 2010 Oct 8.

UPRES EA 3535, Pharmacology and New Anticancer Treatments, University Paris-Sud, Institut Gustave Roussy, Villejuif, France.

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http://doi.wiley.com/10.1002/ijc.25611
Publisher Site
http://dx.doi.org/10.1002/ijc.25611DOI Listing
June 2011

[Indications and current development of new targeted therapies in pediatric oncology].

Bull Cancer 2011 May;98(5):527-39

Centre Oscar-Lambret, unité d'oncologie pédiatrique, 3, rue Frédéric-Combemale, 59020 Lille Cedex, France.

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http://dx.doi.org/10.1684/bdc.2011.1358DOI Listing
May 2011

Anti-insulin-like growth factor 1 receptor antibody EM164 (murine AVE1642) exhibits anti-tumour activity alone and in combination with temozolomide against neuroblastoma.

Eur J Cancer 2010 Dec 28;46(18):3251-62. Epub 2010 Jun 28.

UPRES EA 3535, Pharmacology and New Treatments of Cancer, Université Paris-Sud XI, Institut Gustave Roussy, 94805 Villejuif, France.

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https://linkinghub.elsevier.com/retrieve/pii/S09598049100048
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http://dx.doi.org/10.1016/j.ejca.2010.06.005DOI Listing
December 2010

New anti-angiogenic strategies in pediatric solid malignancies: agents and biomarkers of a near future.

Expert Opin Investig Drugs 2010 Jul;19(7):859-74

Translational Research Laboratory, Institut Gustave Roussy, Villejuif, France.

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http://dx.doi.org/10.1517/13543784.2010.487654DOI Listing
July 2010

The role of the 'innovative therapies for children with cancer' (ITCC) European consortium.

Cancer Treat Rev 2010 Jun 15;36(4):328-34. Epub 2010 Mar 15.

Dept. of Ped Oncology/Hematology, Erasmus MC/Sophia Children's Hospital, GJ Rotterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.ctrv.2010.02.008DOI Listing
June 2010

High levels of circulating VEGFR2+ Bone marrow-derived progenitor cells correlate with metastatic disease in patients with pediatric solid malignancies.

Clin Cancer Res 2009 Jul;15(14):4561-71

Laboratory of Translational Research, University of Paris-Sud, UPRES EA 3535, Pharmacology and New Treatments in Cancer, France.

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http://dx.doi.org/10.1158/1078-0432.CCR-08-2363DOI Listing
July 2009

Candidate genes on chromosome 9q33-34 involved in the progression of childhood ependymomas.

J Clin Oncol 2009 Apr 16;27(11):1884-92. Epub 2009 Mar 16.

Department of Neurosurgery, Peter B Dirks, Christian Sainte-Rose, and Gilles Vassal Hôpital Necker Enfants Malades, Université Paris Descartes, France.

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http://dx.doi.org/10.1200/JCO.2007.15.4195DOI Listing
April 2009

EGFR inhibition using gefitinib is not active in neuroblastoma cell lines.

Anticancer Res 2009 Apr;29(4):1327-33

Department of Pediatrics and Adolescent Medicine, University Hospital of Freiburg, 79106 Freiburg, Germany.

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April 2009

Angiogenesis as a target in neuroblastoma.

Eur J Cancer 2008 Aug 7;44(12):1645-56. Epub 2008 Jul 7.

Pharmacology and New Treatments in Cancer, Institut Gustave Roussy, University of Paris-Sud, UPRES EA3535, Villejuif, France.

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http://dx.doi.org/10.1016/j.ejca.2008.05.015DOI Listing
August 2008

EGFR tyrosine kinase inhibition radiosensitizes and induces apoptosis in malignant glioma and childhood ependymoma xenografts.

Int J Cancer 2008 Jul;123(1):209-16

Université Paris XI-IFR54, UPRES EA 3535 Pharmacology and New Treatment in Cancers, Institut Gustave Roussy, Villejuif, France.

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http://dx.doi.org/10.1002/ijc.23488DOI Listing
July 2008

Small molecule tyrosine kinase inhibitors: potential role in pediatric malignant solid tumors.

Curr Cancer Drug Targets 2008 Feb;8(1):76-85

Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, University Hospital of Freiburg, 79106 Freiburg, Germany.

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February 2008

Stereotactic biopsy of diffuse pontine lesions in children.

J Neurosurg 2007 Jul;107(1 Suppl):1-4

Department of Pediatric Neurosurgery, Hôpital Necker-Enfants Malades, Paris, France.

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http://dx.doi.org/10.3171/PED-07/07/001DOI Listing
July 2007

p53 Pathway dysfunction in primary childhood ependymomas.

Pediatr Blood Cancer 2006 May;46(5):604-13

Pharmacology and New Treatments in Cancer UPRES EA 3535, Institut Gustave Roussy, Villejuif, France.

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http://dx.doi.org/10.1002/pbc.20532DOI Listing
May 2006

[Conditionally replicative adenoviruses: a second wind for cancer gene therapy].

Bull Cancer 2003 Dec;90(12):1039-48

UPRES EA 3535, Pharmacologie et nouveaux traitements des cancers, Institut Gustave-Roussy, 94805 Villejuif.

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December 2003

Oncolytic activity of the E1B-55 kDa-deleted adenovirus ONYX-015 is independent of cellular p53 status in human malignant glioma xenografts.

Cancer Res 2002 Feb;62(3):764-72

Department of Pediatrics, Laboratory of Pharmacotoxicology, Institut Gustave-Roussy, 39 Rue Camille Desmoulins, 94 805 Villejuif, France.

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February 2002