Binhua P Zhou

Binhua P Zhou

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Binhua P Zhou

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IL6/STAT3 Signaling Orchestrates Premetastatic Niche Formation and Immunosuppressive Traits in Lung.

Cancer Res 2020 Feb 17;80(4):784-797. Epub 2019 Dec 17.

Key Laboratory of Cell Differentiation and Apoptosis of Chinese Minister of Education, Shanghai Jiao Tong University, Shanghai, China.

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http://dx.doi.org/10.1158/0008-5472.CAN-19-2013DOI Listing
February 2020

Hsp47 promotes cancer metastasis by enhancing collagen-dependent cancer cell-platelet interaction.

Proc Natl Acad Sci U S A 2020 Feb 3. Epub 2020 Feb 3.

Markey Cancer Center, University of Kentucky, Lexington, KY 40536;

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http://dx.doi.org/10.1073/pnas.1911951117DOI Listing
February 2020

PTGES/PGE signaling links immunosuppression and lung metastasis in Gprc5a-knockout mouse model.

Oncogene 2020 Feb 14. Epub 2020 Feb 14.

Key Laboratory of Cell Differentiation and Apoptosis of Chinese Minister of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

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http://dx.doi.org/10.1038/s41388-020-1207-6DOI Listing
February 2020

Deletion of tetraspanin CD151 alters the Wnt oncogene-induced mammary tumorigenesis: A cell type-linked function and signaling.

Neoplasia 2019 12 26;21(12):1151-1163. Epub 2019 Nov 26.

Department of Pharmacology and Nutritional Sciences, Department of Molecular and Cellular Biochemistry, Markey Cancer Center, University of Kentucky, Lexington, KY. Electronic address:

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http://dx.doi.org/10.1016/j.neo.2019.08.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6888732PMC
December 2019

Oncometabolite modification of Keap1 links GSTZ1 deficiency with cancer.

Genes Dis 2019 Dec 19;6(4):333-334. Epub 2019 Oct 19.

Department of Biochemistry, Markey Cancer Center, University of Kentucky College of Medicine, Lexington, KY, 40536, USA.

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http://dx.doi.org/10.1016/j.gendis.2019.10.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6889240PMC
December 2019

Stabilization of PTGES by deubiquitinase USP9X promotes metastatic features of lung cancer via PGE signaling.

Am J Cancer Res 2019 1;9(6):1145-1160. Epub 2019 Jun 1.

Key Laboratory of Cell Differentiation and Apoptosis of Chinese Minister of Education, Shanghai Jiao Tong University School of Medicine Shanghai, China.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6610053PMC
June 2019

Twist promotes tumor metastasis in basal-like breast cancer by transcriptionally upregulating ROR1.

Theranostics 2018 9;8(10):2739-2751. Epub 2018 Apr 9.

State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangzhou 510060, P. R. China.

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http://dx.doi.org/10.7150/thno.21477DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5957006PMC
May 2019

ITCH nuclear translocation and H1.2 polyubiquitination negatively regulate the DNA damage response.

Nucleic Acids Res 2019 01;47(2):824-842

Department of Cancer Genetics and Epigenetics, Beckman Research Institute, City of Hope, Duarte, CA 91010, USA.

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http://dx.doi.org/10.1093/nar/gky1199DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344871PMC
January 2019

Nanoparticle Delivery of miR-34a Eradicates Long-term-cultured Breast Cancer Stem Cells via Targeting C22ORF28 Directly.

Theranostics 2017 17;7(19):4805-4824. Epub 2017 Oct 17.

Department of Breast Oncology, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China.

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http://dx.doi.org/10.7150/thno.20771DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5706101PMC
July 2018

The regulation of snail: on the ubiquitin edge.

Cancer Cell Microenviron 2017 3;4(2). Epub 2017 Jul 3.

Pharmacology and Nutritional Sciences, the University of Kentucky, College of Medicine, Lexington, KY 40506, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5685547PMC
July 2017

The Role of Stromal Components in Pancreatic Cancer Progression.

Anticancer Agents Med Chem 2016 ;16(9):1117-24

Department of Oncology, the First Affiliated Hospital of Soochow University, Suzhou 215006, China.

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http://dx.doi.org/10.2174/1871520616666160404115532DOI Listing
June 2017

The Role of Tumor Associated Macrophages in the Tumor Microenvironment: Mechanism and Functions.

Anticancer Agents Med Chem 2016 ;16(9):1133-41

Department of Oncology, the First Affiliated Hospital of Soochow University, Suzhou 215006, China.

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http://dx.doi.org/10.2174/1871520616666160520112622DOI Listing
June 2017

POMC maintains tumor-initiating properties of tumor tissue-derived long-term-cultured breast cancer stem cells.

Int J Cancer 2017 06 16;140(11):2517-2525. Epub 2017 Mar 16.

Department of Breast Oncology, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Collaborative Innovation Center for Cancer Medicine, Guangzhou, 510060, China.

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http://doi.wiley.com/10.1002/ijc.30658
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http://dx.doi.org/10.1002/ijc.30658DOI Listing
June 2017

KDM1 links nuclear GSK3β to epigenetic alterations.

Transl Cancer Res 2017 Mar;6(Suppl 2):S366-S368

Department of Molecular and Cellular Biochemistry, and Markey Cancer Center, University of Kentucky, College of Medicine, Lexington, USA.

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http://dx.doi.org/10.21037/tcr.2017.03.26DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370299PMC
March 2017

Epigenetic regulation of LSD1 during mammary carcinogenesis.

Mol Cell Oncol 2014 Jul-Sep;1(3):e963426. Epub 2014 Dec 23.

Markey Cancer Center; College of Medicine; University of Kentucky; Lexington, KY USA; Department of Molecular and Cellular Biochemistry; College of Medicine; University of Kentucky; Lexington, KY USA.

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http://dx.doi.org/10.4161/21624011.2014.963426DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4904887PMC
June 2016

Metabolic rewiring in cancer-associated fibroblasts provides a niche for oncogenesis and metastatic dissemination.

Mol Cell Oncol 2016 Jan-Feb;3(1):e1056331. Epub 2015 Dec 14.

Department of Molecular and Cellular Biochemistry; Markey Cancer Center, University of Kentucky College of Medicine, Lexington, Kentucky, USA.

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https://www.tandfonline.com/doi/full/10.1080/23723556.2015.1
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http://dx.doi.org/10.1080/23723556.2015.1056331DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4845206PMC
June 2016

Twist-mediated Epithelial-mesenchymal Transition Promotes Breast Tumor Cell Invasion via Inhibition of Hippo Pathway.

Sci Rep 2016 Apr 20;6:24606. Epub 2016 Apr 20.

Department of Molecular and Cellular Biochemistry, and Markey Cancer Center, the University of Kentucky, College of Medicine, Lexington, KY 40506, United States.

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http://dx.doi.org/10.1038/srep24606DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4837350PMC
April 2016

Inflammation fuels tumor progress and metastasis.

Curr Pharm Des 2015 ;21(21):3032-40

Department of Molecular and Cellular Biochemistry, 741 South Limestone Street, Lexington, KY 40536.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5644345PMC
http://dx.doi.org/10.2174/1381612821666150514105741DOI Listing
March 2016

Autophagy regulation in the development and treatment of breast cancer.

Acta Biochim Biophys Sin (Shanghai) 2016 Jan 5;48(1):60-74. Epub 2015 Dec 5.

Department of Molecular and Cellular Biochemistry, University of Kentucky School of Medicine, Lexington, KY 40506, USA Department of Markey Cancer Center, University of Kentucky School of Medicine, Lexington, KY 40506, USA

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http://dx.doi.org/10.1093/abbs/gmv119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4689162PMC
January 2016

Twist-BRD4 complex: potential drug target for basal-like breast cancer.

Curr Pharm Des 2015 ;21(10):1256-61

750 Rose Street, Room 377, Lexington, KY 40536.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5644350PMC
http://dx.doi.org/10.2174/1381612821666141211153853DOI Listing
October 2015

Metabolic reprogramming of the tumour microenvironment.

FEBS J 2015 Oct 25;282(20):3892-8. Epub 2015 Aug 25.

Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory of Tumor Microenvironment and Inflammation, Shanghai Jiao Tong University School of Medicine, China.

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http://doi.wiley.com/10.1111/febs.13402
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http://dx.doi.org/10.1111/febs.13402DOI Listing
October 2015

The impact of low-dose carcinogens and environmental disruptors on tissue invasion and metastasis.

Carcinogenesis 2015 Jun;36 Suppl 1:S128-59

Department of Biochemistry and Cancer Biology, Meharry Medical College, Nashville, TN 37208, USA, Department of Environmental and Occupational Health, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA, Department of Biology/Center for Cancer Research and Therapeutic Development, Clark Atlanta University, Atlanta, GA 30314, USA, Department of Cancer Biology, Vanderbilt University, Nashville, TN 37232, USA, Department of Pathology, Wayne State University, Detroit, MI 48201, USA, Department of Obstetrics and Gynecology, University of Melbourne, Melbourne, Victoria, Australia, Faculty of Pharmacy, Department of Pathology, Kuwait University, Safat 13110, Kuwait, Department of Otolaryngology, University of Michigan Medical College, Ann Arbor, MI 48109, USA, Department of Molecular & Cellular Biochemistry, University of Kentucky, Lexington, KY 40506, USA, Department of Environmental and Radiological Health Sciences/Food Science and Human Nutrition, College of Veterinary Medicine and Biomedical Sciences, Colorado State University/Colorado School of Public Health, Fort Collins, CO 80523-1680, USA, Center for Environmental Carcinogenesis and Risk Assessment, Environmental Protection and Health Prevention Agency, Bologna 40126, Italy, Faculty of Medicine and Health Sciences, University Putra, Serdang, Selangor 43400, Malaysia, Istituto di Genetica Molecolare, CNR, via Abbiategrasso 207, 27100 Pavia, Italy, Toxicology Research Division, Bureau of Chemical Safety Food Directorate, Health Products and Food Branch Health Canada, Ottawa, Ontario K1A0K9, Canada, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC 20057, USA, Centre for Advanced Research, King George's Medical University, Chowk, Lucknow, Uttar Pradesh 226003, India, Mediterranean Institute of Oncology, Viagrande 95029, Italy, Urology Department, kasr Al-Ainy School of Medicine, Cairo University, El Manial, Cairo 12515, Egypt, Department of Experimental and

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http://carcin.oxfordjournals.org/content/36/Suppl_1/S128.ful
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http://www.carcin.oxfordjournals.org/lookup/doi/10.1093/carc
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http://dx.doi.org/10.1093/carcin/bgv034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4565611PMC
June 2015

Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead.

Authors:
William H Goodson Leroy Lowe David O Carpenter Michael Gilbertson Abdul Manaf Ali Adela Lopez de Cerain Salsamendi Ahmed Lasfar Amancio Carnero Amaya Azqueta Amedeo Amedei Amelia K Charles Andrew R Collins Andrew Ward Anna C Salzberg Annamaria Colacci Ann-Karin Olsen Arthur Berg Barry J Barclay Binhua P Zhou Carmen Blanco-Aparicio Carolyn J Baglole Chenfang Dong Chiara Mondello Chia-Wen Hsu Christian C Naus Clement Yedjou Colleen S Curran Dale W Laird Daniel C Koch Danielle J Carlin Dean W Felsher Debasish Roy Dustin G Brown Edward Ratovitski Elizabeth P Ryan Emanuela Corsini Emilio Rojas Eun-Yi Moon Ezio Laconi Fabio Marongiu Fahd Al-Mulla Ferdinando Chiaradonna Firouz Darroudi Francis L Martin Frederik J Van Schooten Gary S Goldberg Gerard Wagemaker Gladys N Nangami Gloria M Calaf Graeme Williams Gregory T Wolf Gudrun Koppen Gunnar Brunborg H Kim Lyerly Harini Krishnan Hasiah Ab Hamid Hemad Yasaei Hideko Sone Hiroshi Kondoh Hosni K Salem Hsue-Yin Hsu Hyun Ho Park Igor Koturbash Isabelle R Miousse A Ivana Scovassi James E Klaunig Jan Vondráček Jayadev Raju Jesse Roman John Pierce Wise Jonathan R Whitfield Jordan Woodrick Joseph A Christopher Josiah Ochieng Juan Fernando Martinez-Leal Judith Weisz Julia Kravchenko Jun Sun Kalan R Prudhomme Kannan Badri Narayanan Karine A Cohen-Solal Kim Moorwood Laetitia Gonzalez Laura Soucek Le Jian Leandro S D'Abronzo Liang-Tzung Lin Lin Li Linda Gulliver Lisa J McCawley Lorenzo Memeo Louis Vermeulen Luc Leyns Luoping Zhang Mahara Valverde Mahin Khatami Maria Fiammetta Romano Marion Chapellier Marc A Williams Mark Wade Masoud H Manjili Matilde E Lleonart Menghang Xia Michael J Gonzalez Michalis V Karamouzis Micheline Kirsch-Volders Monica Vaccari Nancy B Kuemmerle Neetu Singh Nichola Cruickshanks Nicole Kleinstreuer Nik van Larebeke Nuzhat Ahmed Olugbemiga Ogunkua P K Krishnakumar Pankaj Vadgama Paola A Marignani Paramita M Ghosh Patricia Ostrosky-Wegman Patricia A Thompson Paul Dent Petr Heneberg Philippa Darbre Po Sing Leung Pratima Nangia-Makker Qiang Shawn Cheng R Brooks Robey Rabeah Al-Temaimi Rabindra Roy Rafaela Andrade-Vieira Ranjeet K Sinha Rekha Mehta Renza Vento Riccardo Di Fiore Richard Ponce-Cusi Rita Dornetshuber-Fleiss Rita Nahta Robert C Castellino Roberta Palorini Roslida Abd Hamid Sabine A S Langie Sakina E Eltom Samira A Brooks Sandra Ryeom Sandra S Wise Sarah N Bay Shelley A Harris Silvana Papagerakis Simona Romano Sofia Pavanello Staffan Eriksson Stefano Forte Stephanie C Casey Sudjit Luanpitpong Tae-Jin Lee Takemi Otsuki Tao Chen Thierry Massfelder Thomas Sanderson Tiziana Guarnieri Tove Hultman Valérian Dormoy Valerie Odero-Marah Venkata Sabbisetti Veronique Maguer-Satta W Kimryn Rathmell Wilhelm Engström William K Decker William H Bisson Yon Rojanasakul Yunus Luqmani Zhenbang Chen Zhiwei Hu

Carcinogenesis 2015 Jun;36 Suppl 1:S254-96

Department of Surgery, The Ohio State University College of Medicine, The James Comprehensive Cancer Center, Columbus, OH 43210, USA.

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http://carcin.oxfordjournals.org/content/36/Suppl_1/S254.ful
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http://carcin.oxfordjournals.org/content/36/Suppl_1/S254.ful
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http://www.ilcambiamento.it/files/carcinogenesi.pdf
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http://www.carcin.oxfordjournals.org/lookup/doi/10.1093/carc
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http://dx.doi.org/10.1093/carcin/bgv039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4480130PMC
June 2015

Lung Tumor Suppressor GPRC5A Binds EGFR and Restrains Its Effector Signaling.

Cancer Res 2015 May 5;75(9):1801-14. Epub 2015 Mar 5.

Key Laboratory of Cell Differentiation and Apoptosis of Chinese Minister of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Department of Pathophysiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Translation Medicine Center, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China.

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http://dx.doi.org/10.1158/0008-5472.CAN-14-2005DOI Listing
May 2015

Chaperone Hsp47 Drives Malignant Growth and Invasion by Modulating an ECM Gene Network.

Cancer Res 2015 Apr 5;75(8):1580-91. Epub 2015 Mar 5.

Markey Cancer Center, University of Kentucky, Lexington, Kentucky. Department of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, Kentucky.

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http://dx.doi.org/10.1158/0008-5472.CAN-14-1027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4401637PMC
April 2015

Metabolic reprogramming of cancer-associated fibroblasts by IDH3α downregulation.

Cell Rep 2015 Mar 26;10(8):1335-48. Epub 2015 Feb 26.

Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory of Tumor Microenvironment and Inflammation, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai 200025, China. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.02.006DOI Listing
March 2015

Doxorubicin enhances Snail/LSD1-mediated PTEN suppression in a PARP1-dependent manner.

Cell Cycle 2014 25;13(11):1708-16. Epub 2014 Mar 25.

Departments of Molecular and Cellular Biochemistry and Markey Cancer Center; University of Kentucky College of Medicine; Lexington, KY USA; Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China and Collaborative Innovation Center of Cancer Medicine; Guangzhou, China.

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http://dx.doi.org/10.4161/cc.28619DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4111717PMC
January 2015

Epigenetic regulation of EMT: the Snail story.

Curr Pharm Des 2014 ;20(11):1698-705

Department of Molecular and Cellular Biochemistry, University of Kentucky School of Medicine, Lexington, KY 40506-0509.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4005722PMC
http://dx.doi.org/10.2174/13816128113199990512DOI Listing
December 2014

EGFR phosphorylates and inhibits lung tumor suppressor GPRC5A in lung cancer.

Mol Cancer 2014 Oct 14;13:233. Epub 2014 Oct 14.

Department of Pathophysiology, Key laboratory of Cell Differentiation and Apoptosis of Minister of Education, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.

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http://molecular-cancer.biomedcentral.com/articles/10.1186/1
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http://dx.doi.org/10.1186/1476-4598-13-233DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4200229PMC
October 2014

Disrupting the interaction of BRD4 with diacetylated Twist suppresses tumorigenesis in basal-like breast cancer.

Cancer Cell 2014 Feb;25(2):210-25

Department of Molecular and Cellular Biochemistry, College of Medicine, University of Kentucky, Lexington, KY 40506, USA; Markey Cancer Center, College of Medicine, University of Kentucky, Lexington, KY 40506, USA; Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, and Collaborative Innovation Center of Cancer Medicine, Guangzhou 510060, China. Electronic address:

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http://dx.doi.org/10.1016/j.ccr.2014.01.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4004960PMC
February 2014

The Role of Snail in EMT and Tumorigenesis.

Curr Cancer Drug Targets 2013 Nov;13(9):963-972

Departments of Molecular and Cellular Biochemistry, and Markey Cancer Center, University of Kentucky School of Medicine, Lexington, KY, 40506, United States.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4004763PMC
http://dx.doi.org/10.2174/15680096113136660102DOI Listing
November 2013

The deubiquitinase USP28 stabilizes LSD1 and confers stem-cell-like traits to breast cancer cells.

Cell Rep 2013 Oct 26;5(1):224-36. Epub 2013 Sep 26.

Department of Molecular and Biomedical Pharmacology, University of Kentucky, College of Medicine, Lexington, KY 40506, USA; Markey Cancer Center, University of Kentucky, College of Medicine, Lexington, KY 40506, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2013.08.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4004762PMC
October 2013

Histone mimics: digging down under.

Front Biol (Beijing) 2013 Apr;8(2):228-233

Departments of Molecular and Cellular Biochemistry, and Markey Cancer Center, College of Medicine, The University of Kentucky, Lexington, KY 40506, USA.

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http://dx.doi.org/10.1007/s11515-012-1211-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4067130PMC
April 2013

Loss of FBP1 by Snail-mediated repression provides metabolic advantages in basal-like breast cancer.

Cancer Cell 2013 Mar 28;23(3):316-31. Epub 2013 Feb 28.

Department of Molecular and Cellular Biochemistry, The University of Kentucky, College of Medicine, Lexington, KY 40506, USA.

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http://dx.doi.org/10.1016/j.ccr.2013.01.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3703516PMC
March 2013

Epithelial-mesenchymal Transition---A Hallmark of Breast Cancer Metastasis.

Cancer Hallm 2013 Mar;1(1):38-49

Departments of Molecular and Cellular Biochemistry, and Markey Cancer Center, University of Kentucky School of Medicine, Lexington, KY, 40506.

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http://dx.doi.org/10.1166/ch.2013.1004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3944831PMC
March 2013

FBW7-Aurora B-p53 feedback loop regulates mitosis and cell growth.

Cell Cycle 2012 Nov 25;11(22):4113-4. Epub 2012 Oct 25.

Department of Molecular and Cellular Biochemistry and Markey Cancer Center, University of Kentucky School of Medicine, Lexington, KY, USA.

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http://dx.doi.org/10.4161/cc.22607DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3524204PMC
November 2012

RORα suppresses breast tumor invasion by inducing SEMA3F expression.

Cancer Res 2012 Apr 20;72(7):1728-39. Epub 2012 Feb 20.

Markey Cancer Center, and the Department of Molecular and Biomedical Pharmacology, Surgery, and Molecular and Cellular Biochemistry, University of Kentucky, Lexington, Kentucky 40536, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-11-2762DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3319846PMC
April 2012

G9a interacts with Snail and is critical for Snail-mediated E-cadherin repression in human breast cancer.

J Clin Invest 2012 Apr 12;122(4):1469-86. Epub 2012 Mar 12.

Department of Molecular and Cellular Biochemistry, The University of Kentucky, College of Medicine, Lexington, Kentucky 40506-0509, USA.

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http://dx.doi.org/10.1172/JCI57349DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3314447PMC
April 2012

Epithelial-mesenchymal transition in breast cancer progression and metastasis.

Chin J Cancer 2011 Sep;30(9):603-11

Department of Molecular and Cellular Biochemistry, University of Kentucky College of Medicine, Lexington, KY 40506, USA.

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http://dx.doi.org/10.5732/cjc.011.10226DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3702729PMC
September 2011

Activation of β-catenin and Akt pathways by Twist are critical for the maintenance of EMT associated cancer stem cell-like characters.

BMC Cancer 2011 Feb 1;11:49. Epub 2011 Feb 1.

Department of Molecular and Cellular Biochemistry, University of Kentucky School of Medicine, Lexington, KY 40506, USA.

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http://bmccancer.biomedcentral.com/articles/10.1186/1471-240
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http://dx.doi.org/10.1186/1471-2407-11-49DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3040162PMC
February 2011

Snail: More than EMT.

Cell Adh Migr 2010 Apr-Jun;4(2):199-203. Epub 2010 Apr 14.

Department of Molecular and Biomedical Pharmacology, University of Kentucky School of Medicine, Lexington, KY, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2900613PMC
http://dx.doi.org/10.4161/cam.4.2.10943DOI Listing
November 2010

The SNAG domain of Snail1 functions as a molecular hook for recruiting lysine-specific demethylase 1.

EMBO J 2010 Jun 13;29(11):1803-16. Epub 2010 Apr 13.

Departments of Molecular and Cellular Biochemistry, University of Kentucky College of Medicine, Lexington, KY, USA.

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http://dx.doi.org/10.1038/emboj.2010.63DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2885925PMC
June 2010

Snail is critical for tumor growth and metastasis of ovarian carcinoma.

Int J Cancer 2010 May;126(9):2102-11

Department of Pathology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, People's Republic of China.

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http://dx.doi.org/10.1002/ijc.24901DOI Listing
May 2010

PTEN loss induces epithelial--mesenchymal transition in human colon cancer cells.

Anticancer Res 2009 Nov;29(11):4439-49

Markey Cancer Center, University of Kentucky, Lexington, KY 40536-0093, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2932708PMC
November 2009

Inflammation: a driving force speeds cancer metastasis.

Cell Cycle 2009 Oct 3;8(20):3267-73. Epub 2009 Oct 3.

Department of Molecular and Biomedical Pharmacology, University of Kentucky School of Medicine, Lexington, KY, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3702728PMC
http://dx.doi.org/10.4161/cc.8.20.9699DOI Listing
October 2009

Stabilization of snail by NF-kappaB is required for inflammation-induced cell migration and invasion.

Cancer Cell 2009 May;15(5):416-28

Department of Pharmacology and Toxicology, The University of Texas Medical Branch, Galveston, TX 77555, USA.

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http://dx.doi.org/10.1016/j.ccr.2009.03.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2881229PMC
May 2009

Small C-terminal domain phosphatase enhances snail activity through dephosphorylation.

J Biol Chem 2009 Jan 12;284(1):640-8. Epub 2008 Nov 12.

Department of Pharmacology and Toxicology, the University of Texas Medical Branch, Galveston, Texas 77555, USA.

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http://dx.doi.org/10.1074/jbc.M806916200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2610500PMC
January 2009

New insights of epithelial-mesenchymal transition in cancer metastasis.

Acta Biochim Biophys Sin (Shanghai) 2008 Jul;40(7):643-50

Department of Pharmacology and Toxicology, Sealy Center for Cancer Cell Biology, The University of Texas Medical Branch, Galveston, Texas 77555, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2740620PMC
http://dx.doi.org/10.1111/j.1745-7270.2008.00443.xDOI Listing
July 2008

Kinases meet at TSC.

Cell Res 2007 Dec;17(12):971-3

Department of Pharmacology and Toxicology and Sealy Center for Cancer Cell Biology, University of Texas Medical Branch, Galveston, TX 77555-1048, USA.

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http://dx.doi.org/10.1038/cr.2007.106DOI Listing
December 2007

Akt-mediated phosphorylation of EZH2 suppresses methylation of lysine 27 in histone H3.

Science 2005 Oct;310(5746):306-10

Department of Molecular and Cellular Oncology, the University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA.

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http://www.sciencemag.org/cgi/doi/10.1126/science.1118947
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October 2005

Wnt, hedgehog and snail: sister pathways that control by GSK-3beta and beta-Trcp in the regulation of metastasis.

Cell Cycle 2005 Jun 13;4(6):772-6. Epub 2005 Jun 13.

Department of Molecular and Cellular Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, USA.

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https://www.tandfonline.com/doi/full/10.4161/cc.4.6.1744
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June 2005

A hypoxia-independent hypoxia-inducible factor-1 activation pathway induced by phosphatidylinositol-3 kinase/Akt in HER2 overexpressing cells.

Cancer Res 2005 Apr;65(8):3257-63

Department of Molecular and Cellular Oncology, University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-04-1284DOI Listing
April 2005

HER-2/Neu signaling and therapeutic approaches in breast cancer.

Breast Dis 2002 ;15:13-24

Department of Molecular and Cellular Oncology, Breast Cancer Basic Research Program, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.3233/bd-2002-15103DOI Listing
March 2005

Upregulation of CXCR4 is essential for HER2-mediated tumor metastasis.

Cancer Cell 2004 Nov;6(5):459-69

Department of Molecular and Cellular Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1016/j.ccr.2004.09.027DOI Listing
November 2004

Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition.

Nat Cell Biol 2004 Oct 26;6(10):931-40. Epub 2004 Sep 26.

Department of Molecular and Cellular Oncology, Breast Cancer Basic Research Program, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1038/ncb1173DOI Listing
October 2004

Phosphorylation/cytoplasmic localization of p21Cip1/WAF1 is associated with HER2/neu overexpression and provides a novel combination predictor for poor prognosis in breast cancer patients.

Clin Cancer Res 2004 Jun;10(11):3815-24

Departments of Molecular and Cellular Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-03-0527DOI Listing
June 2004

Enhancement of Bik antitumor effect by Bik mutants.

Cancer Res 2003 Nov;63(22):7630-3

Department of Molecular and Cellular Oncology, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.

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November 2003

Dysregulation of cellular signaling by HER2/neu in breast cancer.

Semin Oncol 2003 Oct;30(5 Suppl 16):38-48

Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.1053/j.seminoncol.2003.08.006DOI Listing
October 2003

beta-catenin interacts with and inhibits NF-kappa B in human colon and breast cancer.

Cancer Cell 2002 Oct;2(4):323-34

Department of Molecular and Cellular Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.1016/s1535-6108(02)00154-xDOI Listing
October 2002

Novel targets of Akt, p21(Cipl/WAF1), and MDM2.

Semin Oncol 2002 Jun;29(3 Suppl 11):62-70

Department of Molecular and Cellular Oncology, Breast Cancer Basic Research Program, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030-4095, USA.

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http://dx.doi.org/10.1053/sonc.2002.34057DOI Listing
June 2002