Binghui Shen

Binghui Shen

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Binghui Shen

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Functional deficiency of DNA repair gene EXO5 results in androgen-induced genomic instability and prostate tumorigenesis.

Oncogene 2019 Oct 15. Epub 2019 Oct 15.

Department of Cancer Genetics and Epigenetics, Beckman Research Institute of City of Hope, Duarte, USA.

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http://dx.doi.org/10.1038/s41388-019-1061-6DOI Listing
October 2019

Novel mutations in DNA2 associated with myopathy and mtDNA instability.

Ann Clin Transl Neurol 2019 Sep 2;6(9):1893-1899. Epub 2019 Sep 2.

Dino Ferrari Center, Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy.

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http://dx.doi.org/10.1002/acn3.50888DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6764641PMC
September 2019

TRAF6 mediates human DNA2 polyubiquitination and nuclear localization to maintain nuclear genome integrity.

Nucleic Acids Res 2019 Aug;47(14):7564-7579

Department of Cancer Genetics and Epigenetics, Beckman Research Institute of City of Hope, 1500 East Duarte Road, Duarte, CA 91010, USA.

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http://dx.doi.org/10.1093/nar/gkz537DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6698806PMC
August 2019

PRMT1-mediated FLT3 arginine methylation promotes maintenance of FLT3-ITD acute myeloid leukemia.

Blood 2019 Aug 19;134(6):548-560. Epub 2019 Jun 19.

Department of Hematological Malignancies Translational Science, Gehr Family Center for Leukemia Research, Hematologic Malignancies and Stem Cell Transplantation Institute, Beckman Research Institute, City of Hope Medical Center, Duarte, CA.

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http://dx.doi.org/10.1182/blood.2019001282DOI Listing
August 2019

RAD51 and mitotic function of mus81 are essential for recovery from low-dose of camptothecin in the absence of the WRN exonuclease.

Nucleic Acids Res 2019 Jul;47(13):6796-6810

Mechanisms, Biomarkers and Models Unit, Department of Environment and Health, Istituto Superiore di Sanità, Roma, Italy.

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http://dx.doi.org/10.1093/nar/gkz431DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6648349PMC
July 2019

Mina53 regulates the differentiation and proliferation of leukemia cells.

Hematol Oncol 2019 Apr 16. Epub 2019 Apr 16.

College of Life Sciences, Zhejiang University, Hangzhou, China.

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http://dx.doi.org/10.1002/hon.2621DOI Listing
April 2019

A novel thyroid hormone receptor isoform, TRβ2-46, promotes SKP2 expression and retinoblastoma cell proliferation.

J Biol Chem 2019 02 14;294(8):2961-2969. Epub 2019 Jan 14.

From The Vision Center and The Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, California 90027,

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http://www.jbc.org/lookup/doi/10.1074/jbc.AC118.006041
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http://dx.doi.org/10.1074/jbc.AC118.006041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393598PMC
February 2019

ITCH nuclear translocation and H1.2 polyubiquitination negatively regulate the DNA damage response.

Nucleic Acids Res 2019 01;47(2):824-842

Department of Cancer Genetics and Epigenetics, Beckman Research Institute, City of Hope, Duarte, CA 91010, USA.

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http://dx.doi.org/10.1093/nar/gky1199DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344871PMC
January 2019

Triptolide inhibits Wnt signaling in NSCLC through upregulation of multiple Wnt inhibitory factors via epigenetic modifications to Histone H3.

Int J Cancer 2018 11 19;143(10):2470-2478. Epub 2018 Sep 19.

City of Hope Medical Center, Division of Thoracic Surgery, Baum Family Thoracic Oncology laboratory; Beckman Research Institute.

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http://dx.doi.org/10.1002/ijc.31756DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6483070PMC
November 2018

Structural basis of 5' flap recognition and protein-protein interactions of human flap endonuclease 1.

Nucleic Acids Res 2018 11;46(21):11315-11325

Key Laboratory of Chinese Ministry of Agriculture for Nuclear-Agricultural Sciences, Institute of Nuclear-Agricultural Sciences, Zhejiang University, Hangzhou, Zhejiang 310029, China.

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http://dx.doi.org/10.1093/nar/gky911DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6265464PMC
November 2018

Jumonji domain-containing protein family: the functions beyond lysine demethylation.

J Mol Cell Biol 2018 08;10(4):371-373

Department of Cancer Genetics and Epigenetics, Beckman Research Institute of City of Hope, Duarte, CA, USA.

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http://dx.doi.org/10.1093/jmcb/mjy010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6455909PMC
August 2018

hDNA2 nuclease/helicase promotes centromeric DNA replication and genome stability.

EMBO J 2018 07 17;37(14). Epub 2018 May 17.

Department of Cancer Genetics and Epigenetics, Beckman Research Institute, City of Hope, Duarte, CA, USA

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http://dx.doi.org/10.15252/embj.201796729DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6043852PMC
July 2018

SUMO2 conjugation of PCNA facilitates chromatin remodeling to resolve transcription-replication conflicts.

Nat Commun 2018 07 13;9(1):2706. Epub 2018 Jul 13.

Department of Cancer Genetics and Epigenetics, Beckman Research Institute, City of Hope, Duarte, CA, 91010-3000, USA.

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http://dx.doi.org/10.1038/s41467-018-05236-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6045570PMC
July 2018

EGFR-TKI-induced HSP70 degradation and BER suppression facilitate the occurrence of the EGFR T790 M resistant mutation in lung cancer cells.

Cancer Lett 2018 06 7;424:84-96. Epub 2018 Mar 7.

Jiangsu Province Key Laboratory for Molecular and Medical Biotechnology, College of Life Science, Nanjing Normal University, Nanjing, 210046, Jiangsu, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2018.03.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010362PMC
June 2018

Triptolide-Assisted Phosphorylation of p53 Suppresses Inflammation-Induced NF-κB Survival Pathways in Cancer Cells.

Mol Cell Biol 2017 08 14;37(15). Epub 2017 Jul 14.

Department of Cancer Genetics and Epigenetics, City of Hope National Medical Center and Beckman Research Institute, Duarte, California, USA

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http://dx.doi.org/10.1128/MCB.00149-17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5514447PMC
August 2017

Deficiency in Duox2 activity alleviates ileitis in GPx1- and GPx2-knockout mice without affecting apoptosis incidence in the crypt epithelium.

Redox Biol 2017 04 22;11:144-156. Epub 2016 Nov 22.

Department of Cancer Genetics and Epigenetics, Beckman Research Institute of City of Hope, Duarte, CA 91010, USA.

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http://dx.doi.org/10.1016/j.redox.2016.11.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5148781PMC
April 2017

Role of FEN1 S187 phosphorylation in counteracting oxygen-induced stress and regulating postnatal heart development.

FASEB J 2017 01 30;31(1):132-147. Epub 2016 Sep 30.

Department of Cancer Genetics and Epigenetics and Beckman Research Institute of City of Hope, Duarte, California, USA;

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http://www.fasebj.org/doi/10.1096/fj.201600631R
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http://dx.doi.org/10.1096/fj.201600631RDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5161519PMC
January 2017

Targeting DNA Flap Endonuclease 1 to Impede Breast Cancer Progression.

EBioMedicine 2016 Dec 10;14:32-43. Epub 2016 Nov 10.

Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Science, Nanjing Normal University, 1 Wenyuan Road, Nanjing 210023, China. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2016.11.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5161424PMC
December 2016

NADPH oxidase-1 deficiency offers little protection in -induced typhlitis in mice.

World J Gastroenterol 2016 Dec;22(46):10158-10165

Fong-Fong Chu, Department of Gastroenterology and Hepatology, The First Affiliated Hospital and College of Clinical Medicine of Henan University of Science and Technology, Luoyang 471003, Henan Province, China.

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http://www.wjgnet.com/1007-9327/full/v22/i46/10158.htm
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http://dx.doi.org/10.3748/wjg.v22.i46.10158DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5155175PMC
December 2016

Site-specific Disruption of the Oct4/Sox2 Protein Interaction Reveals Coordinated Mesendodermal Differentiation and the Epithelial-Mesenchymal Transition.

J Biol Chem 2016 08 1;291(35):18353-69. Epub 2016 Jul 1.

the State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital, School of Medicine, Zhejiang University, 79 QingChun Road, Hangzhou, Zhejiang 310003, China,

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http://dx.doi.org/10.1074/jbc.M116.745414DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5000082PMC
August 2016

Mutation of DNA Polymerase β R137Q Results in Retarded Embryo Development Due to Impaired DNA Base Excision Repair in Mice.

Sci Rep 2016 06 30;6:28614. Epub 2016 Jun 30.

Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal University, 1 WenYuan Road, Nanjing, 210023, China.

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http://dx.doi.org/10.1038/srep28614DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4928080PMC
June 2016

A Selective Small Molecule DNA2 Inhibitor for Sensitization of Human Cancer Cells to Chemotherapy.

EBioMedicine 2016 Apr 10;6:73-86. Epub 2016 Mar 10.

Department of Cancer Genetics and Epigenetics, Beckman Research Institute, City of Hope, 1500 East Duarte Road, Duarte, CA 91010-3000, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2016.02.043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4856754PMC
April 2016

Shade avoidance 6 encodes an Arabidopsis flap endonuclease required for maintenance of genome integrity and development.

Nucleic Acids Res 2016 Feb 31;44(3):1271-84. Epub 2015 Dec 31.

School of Life Sciences, Xiamen Plant Genetics Key Laboratory, Xiamen University, Xiamen 361102, China State Key Laboratory of Cellular Stress Biology, Xiamen University, Xiamen 361102, China

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http://dx.doi.org/10.1093/nar/gkv1474DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4756833PMC
February 2016

R152C DNA Pol β mutation impairs base excision repair and induces cellular transformation.

Oncotarget 2016 Feb;7(6):6902-15

Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing, China 210023.

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http://dx.doi.org/10.18632/oncotarget.6849DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872757PMC
February 2016

FEN1-mediated α-segment error editing during Okazaki fragment maturation.

Cell Cycle 2015 ;14(12):1767

a Department of Radiation Biology; Beckman Research Institute of City of Hope ; Duarte , CA , USA.

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http://dx.doi.org/10.1080/15384101.2015.1046306DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4614633PMC
October 2015

O-GlcNAcylation of G6PD promotes the pentose phosphate pathway and tumor growth.

Nat Commun 2015 Sep 24;6:8468. Epub 2015 Sep 24.

Institute of Biochemistry, College of Life Sciences, Zhejiang University, Hangzhou 310058, China.

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http://dx.doi.org/10.1038/ncomms9468DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4598839PMC
September 2015

Okazaki fragment maturation involves α-segment error editing by the mammalian FEN1/MutSα functional complex.

EMBO J 2015 Jul 28;34(13):1829-43. Epub 2015 Apr 28.

Departments of Radiation Biology and Molecular Medicine, City of Hope National Medical Center and Beckman Research Institute, Duarte, CA, USA

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http://dx.doi.org/10.15252/embj.201489865DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4516434PMC
July 2015

Tryptophan derivatives regulate the transcription of Oct4 in stem-like cancer cells.

Nat Commun 2015 Jun 10;6:7209. Epub 2015 Jun 10.

State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, China.

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http://dx.doi.org/10.1038/ncomms8209DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490363PMC
June 2015

YY1 suppresses FEN1 over-expression and drug resistance in breast cancer.

BMC Cancer 2015 Feb 13;15:50. Epub 2015 Feb 13.

Departments of Radiation Biology and Molecular Medicine, Beckman Research Institute of City of Hope, 1500 East Duarte Road, Duarte, California, 91010, USA.

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http://dx.doi.org/10.1186/s12885-015-1043-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4348373PMC
February 2015

Nox1 causes ileocolitis in mice deficient in glutathione peroxidase-1 and -2.

Free Radic Biol Med 2014 Mar 25;68:315-25. Epub 2013 Dec 25.

Department of Radiation Biology and Beckman Research Institute, City of Hope, Duarte, CA 91010, USA. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2013.12.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3943970PMC
March 2014

The wonders of flap endonucleases: structure, function, mechanism and regulation.

Subcell Biochem 2012 ;62:301-26

Department of Chemistry, Centre for Chemical Biology, Krebs Institute, University of Sheffield, Sheffield, S3 7HF, UK,

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http://dx.doi.org/10.1007/978-94-007-4572-8_16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3728657PMC
February 2014

B56γ tumor-associated mutations provide new mechanisms for B56γ-PP2A tumor suppressor activity.

Mol Cancer Res 2013 Sep 30;11(9):995-1003. Epub 2013 May 30.

Department of Biochemistry, University of California, Riverside, CA 92521.

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http://dx.doi.org/10.1158/1541-7786.MCR-12-0633DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3778137PMC
September 2013

Mammalian DNA2 helicase/nuclease cleaves G-quadruplex DNA and is required for telomere integrity.

EMBO J 2013 May 19;32(10):1425-39. Epub 2013 Apr 19.

Department of Radiation Biology, City of Hope National Medical Center and Beckman Research Institute, Duarte, CA 91010, USA.

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http://dx.doi.org/10.1038/emboj.2013.88DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3655473PMC
May 2013

Reciprocal regulation of Akt and Oct4 promotes the self-renewal and survival of embryonal carcinoma cells.

Mol Cell 2012 Nov 4;48(4):627-40. Epub 2012 Oct 4.

State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, 79 QingChun Road, Hangzhou, Zhejiang 310003, China.

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http://linkinghub.elsevier.com/retrieve/pii/S109727651200774
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http://dx.doi.org/10.1016/j.molcel.2012.08.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3601782PMC
November 2012

Examining the roles of DNA2 during mammalian end resection.

Cell Cycle 2012 Nov 25;11(22):4111. Epub 2012 Oct 25.

Department of Radiation Biology, City of Hope National Medical Center and Beckman Research Institute, Duarte, CA, USA.

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http://www.tandfonline.com/doi/abs/10.4161/cc.22605
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http://dx.doi.org/10.4161/cc.22605DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3524202PMC
November 2012

Sequential posttranslational modifications program FEN1 degradation during cell-cycle progression.

Mol Cell 2012 Aug 30;47(3):444-56. Epub 2012 Jun 30.

Jiangsu Key Laboratory for Molecular and Medical Biotechnology and College of Life Sciences, Nanjing Normal University, Nanjing 210046, China.

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http://dx.doi.org/10.1016/j.molcel.2012.05.042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3518404PMC
August 2012

Polyploid cells rewire DNA damage response networks to overcome replication stress-induced barriers for tumour progression.

Nat Commun 2012 May 8;3:815. Epub 2012 May 8.

Department of Cancer Biology, City of Hope National Medical Center and Beckman Research Institute, 1500 East Duarte Road, Duarte, California 91010, USA.

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http://www.nature.com/articles/ncomms1825
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http://dx.doi.org/10.1038/ncomms1825DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3517178PMC
May 2012

High risk of benzo[α]pyrene-induced lung cancer in E160D FEN1 mutant mice.

Mutat Res 2012 Mar 6;731(1-2):85-91. Epub 2011 Dec 6.

Colleges of Life Sciences, Zhejiang University, Hangzhou, Zhejiang, China.

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http://dx.doi.org/10.1016/j.mrfmmm.2011.11.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3268909PMC
March 2012

Fen1 mutations that specifically disrupt its interaction with PCNA cause aneuploidy-associated cancer.

Cell Res 2011 Jul 8;21(7):1052-67. Epub 2011 Mar 8.

Department of Cancer Biology, City of Hope National Medical Center and Beckman Research Institute, Duarte, CA 91010, USA.

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http://www.nature.com/articles/cr201135
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http://dx.doi.org/10.1038/cr.2011.35DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3129403PMC
July 2011

Functional regulation of FEN1 nuclease and its link to cancer.

Nucleic Acids Res 2011 Feb 6;39(3):781-94. Epub 2010 Oct 6.

Institute of Cell Biology and Genetics, College of Life Sciences, Zhejiang University, Hangzhou, China.

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http://dx.doi.org/10.1093/nar/gkq884DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3035468PMC
February 2011

Okazaki fragment maturation: nucleases take centre stage.

J Mol Cell Biol 2011 Feb;3(1):23-30

Department of Cancer Biology, City of Hope National Medical Center and Beckman Research Institute, Duarte, CA 91010, USA.

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http://dx.doi.org/10.1093/jmcb/mjq048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3030970PMC
February 2011

Methylation of FEN1 suppresses nearby phosphorylation and facilitates PCNA binding.

Nat Chem Biol 2010 Oct 22;6(10):766-73. Epub 2010 Aug 22.

Department of Cancer Biology, City of Hope National Medical Center and Beckman Research Institute, Duarte, California, USA.

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http://dx.doi.org/10.1038/nchembio.422DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2943039PMC
October 2010

Functional FEN1 polymorphisms are associated with DNA damage levels and lung cancer risk.

Hum Mutat 2009 Sep;30(9):1320-8

Department of Etiology and Carcinogenesis, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.

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http://dx.doi.org/10.1002/humu.21060DOI Listing
September 2009

The 3'-flap pocket of human flap endonuclease 1 is critical for substrate binding and catalysis.

J Biol Chem 2009 Aug 11;284(33):22184-94. Epub 2009 Jun 11.

Division of Radiation Biology, Graduate School of Biological Sciences, City of Hope National Medical Center and Beckman Research Institute, Duarte, CA 91010, USA.

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http://dx.doi.org/10.1074/jbc.M109.015065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2755943PMC
August 2009

Human DNA polymerase beta polymorphism, Arg137Gln, impairs its polymerase activity and interaction with PCNA and the cellular base excision repair capacity.

Nucleic Acids Res 2009 Jun 31;37(10):3431-41. Epub 2009 Mar 31.

Department of Radiation Biology, City of Hope National Medical Center, Beckman Research Institute, Duarte, CA 91010, USA.

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https://academic.oup.com/nar/article-lookup/doi/10.1093/nar/
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http://dx.doi.org/10.1093/nar/gkp201DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2691839PMC
June 2009

Deinococcus radiodurans PprI switches on DNA damage response and cellular survival networks after radiation damage.

Mol Cell Proteomics 2009 Mar 24;8(3):481-94. Epub 2008 Oct 24.

Institute of Nuclear-Agricultural Sciences, Key Laboratory of Chinese Ministry of Agriculture for Nuclear-Agricultural Sciences, Zhejiang University, Hangzhou 310029, China.

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http://dx.doi.org/10.1074/mcp.M800123-MCP200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2649811PMC
March 2009

Human flap endonuclease I is in complex with telomerase and is required for telomerase-mediated telomere maintenance.

J Biol Chem 2009 Feb 9;284(6):3682-90. Epub 2008 Dec 9.

Washington, Wyoming, Alaska, Montana, Idaho Medical Education Program, Washington State University, Spokane, Washington 99210, USA.

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http://dx.doi.org/10.1074/jbc.M805362200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2635043PMC
February 2009

Overexpression and hypomethylation of flap endonuclease 1 gene in breast and other cancers.

Mol Cancer Res 2008 Nov;6(11):1710-7

Department of Radiation Biology, City of Hope National Medical Center and Beckman Research Institute, Duarte, California 91010, USA.

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http://dx.doi.org/10.1158/1541-7786.MCR-08-0269DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2948671PMC
November 2008

Physical and functional interaction between human oxidized base-specific DNA glycosylase NEIL1 and flap endonuclease 1.

J Biol Chem 2008 Oct 28;283(40):27028-37. Epub 2008 Jul 28.

Department of Biochemistry and Molecular Biology, University of Texas, Medical Branch, Galveston, Texas 77555, USA.

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http://dx.doi.org/10.1074/jbc.M802712200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2556012PMC
October 2008

Removal of oxidative DNA damage via FEN1-dependent long-patch base excision repair in human cell mitochondria.

Mol Cell Biol 2008 Aug 9;28(16):4975-87. Epub 2008 Jun 9.

Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1128/MCB.00457-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2519700PMC
August 2008

Nucleolar localization and dynamic roles of flap endonuclease 1 in ribosomal DNA replication and damage repair.

Mol Cell Biol 2008 Jul 28;28(13):4310-9. Epub 2008 Apr 28.

Department of Radiation Biology, City of Hope National Medical Center and Beckman Research Institute, 1500 East Duarte Road, Duarte, CA 91010, USA.

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http://dx.doi.org/10.1128/MCB.00200-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2447149PMC
July 2008

Comprehensive mapping of the C-terminus of flap endonuclease-1 reveals distinct interaction sites for five proteins that represent different DNA replication and repair pathways.

J Mol Biol 2008 Mar 4;377(3):679-90. Epub 2007 Nov 4.

Department of Radiation Biology, City of Hope National Medical Center and Beckman Research Institute, Duarte, CA 91010, USA.

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http://dx.doi.org/10.1016/j.jmb.2007.10.074DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2680686PMC
March 2008

Fen1 mutations result in autoimmunity, chronic inflammation and cancers.

Nat Med 2007 Jul 24;13(7):812-9. Epub 2007 Jun 24.

Department of Radiation Biology, City of Hope National Medical Center and Beckman Research Institute, 1500 East Duarte Road, Duarte, California 91010, USA.

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http://dx.doi.org/10.1038/nm1599DOI Listing
July 2007

Disruption of the FEN-1/PCNA interaction results in DNA replication defects, pulmonary hypoplasia, pancytopenia, and newborn lethality in mice.

Mol Cell Biol 2007 Apr 5;27(8):3176-86. Epub 2007 Feb 5.

City of Hope National Medical Center, Department of Molecular Biology, 1500 East Duarte Rd., Duarte, CA 91010, USA.

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http://dx.doi.org/10.1128/MCB.01652-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1899923PMC
April 2007

Three tandem HRDC domains have synergistic effect on the RecQ functions in Deinococcus radiodurans.

DNA Repair (Amst) 2007 Feb 7;6(2):167-76. Epub 2006 Nov 7.

Institute of Nuclear-Agricultural Sciences, Zhejiang University, Hangzhou 310029, China.

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http://dx.doi.org/10.1016/j.dnarep.2006.09.006DOI Listing
February 2007

Concerted action of exonuclease and Gap-dependent endonuclease activities of FEN-1 contributes to the resolution of triplet repeat sequences (CTG)n- and (GAA)n-derived secondary structures formed during maturation of Okazaki fragments.

J Biol Chem 2007 Feb 30;282(6):3465-77. Epub 2006 Nov 30.

Department of Radiation Biology, City of Hope National Medical Center and Beckman Research Institute, Duarte, California 91010, USA.

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http://dx.doi.org/10.1074/jbc.M606582200DOI Listing
February 2007

The retinitis pigmentosa-mutated RP2 protein exhibits exonuclease activity and translocates to the nucleus in response to DNA damage.

Exp Cell Res 2006 May 2;312(8):1323-34. Epub 2006 Feb 2.

Division of Biology, Beckman Research Institute of the City of Hope, 1500 East Duarte Road, Duarte, CA 91010, USA.

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http://dx.doi.org/10.1016/j.yexcr.2005.12.026DOI Listing
May 2006

The DNA-protein interaction modes of FEN-1 with gap substrates and their implication in preventing duplication mutations.

Nucleic Acids Res 2006 31;34(6):1772-84. Epub 2006 Mar 31.

Department of Radiation Biology, City of Hope National Medical Center and Beckman Research Institute, Duarte, CA 91010, USA.

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http://dx.doi.org/10.1093/nar/gkl106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1421507PMC
April 2006

Multiple but dissectible functions of FEN-1 nucleases in nucleic acid processing, genome stability and diseases.

Bioessays 2005 Jul;27(7):717-29

Department of Radiation Biology, City of Hope National Medical Center and Beckman Research Institute, Duarte, CA 91010, USA.

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http://dx.doi.org/10.1002/bies.20255DOI Listing
July 2005

Dual negative regulatory mechanisms of RecX on RecA functions in radiation resistance, DNA recombination and consequent genome instability in Deinococcus radiodurans.

DNA Repair (Amst) 2005 Jun;4(6):671-8

Institute of Nuclear-Agricultural Sciences, Zhejiang University, 310029 Hangzhou, China.

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http://dx.doi.org/10.1016/j.dnarep.2005.02.006DOI Listing
June 2005

Search for apoptotic nucleases in yeast: role of Tat-D nuclease in apoptotic DNA degradation.

J Biol Chem 2005 Apr 18;280(15):15370-9. Epub 2005 Jan 18.

Department of Radiation Biology, City of Hope National Medical Center and Beckman Research Institute, Duarte, California 91010, USA.

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http://dx.doi.org/10.1074/jbc.M413547200DOI Listing
April 2005

Human 3-methyladenine-DNA glycosylase: effect of sequence context on excision, association with PCNA, and stimulation by AP endonuclease.

J Mol Biol 2005 Mar 20;346(5):1259-74. Epub 2005 Jan 20.

Biology Division, Beckman Research Institute, City of Hope National Medical Center, 1450 East Duarte Road, Duarte, CA 91010, USA.

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http://dx.doi.org/10.1016/j.jmb.2005.01.014DOI Listing
March 2005

Novel function of the flap endonuclease 1 complex in processing stalled DNA replication forks.

EMBO Rep 2005 Jan;6(1):83-9

Department of Radiation Biology, City of Hope National Medical Center and Beckman Research Institute, Duarte, California 91010, USA.

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http://dx.doi.org/10.1038/sj.embor.7400313DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1299223PMC
January 2005

LexA analog (dra0074) is a regulatory protein that is irrelevant to recA induction.

J Biochem 2004 Dec;136(6):787-93

Institute of Nuclear-Agricultural Sciences, Zhejiang University, 310029, Hangzhou, China.

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http://dx.doi.org/10.1093/jb/mvh188DOI Listing
December 2004

Mutational spectra of p53 in geographically localized esophageal squamous cell carcinoma groups in China.

Cancer 2004 Aug;101(4):834-44

Department of Pathology, Xinxiang Medical College, Xinxiang, Henan, People's Republic of China.

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http://doi.wiley.com/10.1002/cncr.20437
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http://dx.doi.org/10.1002/cncr.20437DOI Listing
August 2004

Interaction interface of human flap endonuclease-1 with its DNA substrates.

J Biol Chem 2004 Jun 22;279(23):24394-402. Epub 2004 Mar 22.

Department of Radiation Research, City of Hope National Medical Center and Beckman Research Institute, Duarte, California 91010, USA.

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http://dx.doi.org/10.1074/jbc.M401464200DOI Listing
June 2004

Structural basis for FEN-1 substrate specificity and PCNA-mediated activation in DNA replication and repair.

Cell 2004 Jan;116(1):39-50

Department of Molecular Biology and Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92122, USA.

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http://dx.doi.org/10.1016/s0092-8674(03)01036-5DOI Listing
January 2004

Expression of Deinococcus radiodurans PprI enhances the radioresistance of Escherichia coli.

DNA Repair (Amst) 2003 Dec;2(12):1419-27

Institute of Nuclear-Agricultural Science, Zhejiang University, 310029, China.

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December 2003

Interaction and stimulation of human FEN-1 nuclease activities by heterogeneous nuclear ribonucleoprotein A1 in alpha-segment processing during Okazaki fragment maturation.

Biochemistry 2003 Dec;42(51):15045-52

Division of Molecular Biology, City of Hope National Medical Center and Beckman Research Institute, Duarte, California 91010, USA.

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http://dx.doi.org/10.1021/bi035364tDOI Listing
December 2003

Complementary functions of the Saccharomyces cerevisiae Rad2 family nucleases in Okazaki fragment maturation, mutation avoidance, and chromosome stability.

DNA Repair (Amst) 2003 Aug;2(8):925-40

Division of Molecular Biology, City of Hope National Medical Center, Duarte, CA 91010, USA.

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August 2003

CRN-1, a Caenorhabditis elegans FEN-1 homologue, cooperates with CPS-6/EndoG to promote apoptotic DNA degradation.

EMBO J 2003 Jul;22(13):3451-60

Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, CO 80309, USA.

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http://dx.doi.org/10.1093/emboj/cdg320DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC165645PMC
July 2003

PprI: a general switch responsible for extreme radioresistance of Deinococcus radiodurans.

Biochem Biophys Res Commun 2003 Jun;306(2):354-60

Institute of Nuclear-Agricultural Science, Zhejiang University, 310029, Hangzhou, China.

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http://dx.doi.org/10.1016/s0006-291x(03)00965-3DOI Listing
June 2003

Functional alterations of human exonuclease 1 mutants identified in atypical hereditary nonpolyposis colorectal cancer syndrome.

Cancer Res 2002 Nov;62(21):6026-30

Division of Molecular Medicine, City of Hope National Medical Center and Beckman Research Institute, Duarte, California 91010, USA.

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November 2002

Suppression of Saccharomyces cerevisiae rad27 null mutant phenotypes by the 5' nuclease domain of Escherichia coli DNA polymerase I.

Curr Genet 2002 Sep 23;41(6):379-88. Epub 2002 Aug 23.

Division of Molecular Medicine, City of Hope National Medical Center and Beckman Research Institute, Duarte, CA 91010, USA.

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http://dx.doi.org/10.1007/s00294-002-0323-xDOI Listing
September 2002

Distinct roles of two Mg2+ binding sites in regulation of murine flap endonuclease-1 activities.

Biochemistry 2002 Aug;41(32):10323-31

Division of Molecular Medicine, City of Hope National Medical Center and Beckman Research Institute, Duarte, California 91010, USA.

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http://dx.doi.org/10.1021/bi025841sDOI Listing
August 2002

Arginine residues 47 and 70 of human flap endonuclease-1 are involved in DNA substrate interactions and cleavage site determination.

J Biol Chem 2002 Jul 1;277(27):24659-66. Epub 2002 May 1.

Division of Molecular Medicine, City of Hope National Medical Center and Beckman Research Institute, Duarte, California 91010, USA.

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http://dx.doi.org/10.1074/jbc.M111941200DOI Listing
July 2002

Activation of nuclear factor kappaB in radioresistance of TP53-inactive human keratinocytes.

Cancer Res 2002 Feb;62(4):1213-21

Department of Cell and Tumor Biology, Beckman Research Institute, City of Hope National Medical Center, Duarte, California 91010, USA.

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February 2002