Publications by authors named "Bing Liu"

2,040 Publications

  • Page 1 of 1

Lightweight Self-Detection and Self-Calibration Strategy for MEMS Gas Sensor Arrays.

Sensors (Basel) 2022 Jun 7;22(12). Epub 2022 Jun 7.

School of Electronics and Information Engineering, Harbin Institute of Technology, Harbin 150080, China.

With the development of Internet of Things (IoT) and edge computing technology, gas sensor arrays based on Micro-Electro-Mechanical System (MEMS) fabrication technique have broad application prospects in intelligent integrated systems, portable devices, and other fields. In such complex scenarios, the normal operation of a gas sensing system depends heavily on the accuracy of the sensor output. Therefore, a lightweight Self-Detection and Self-Calibration strategy for MEMS gas sensor arrays is proposed in this paper to monitor the working status of sensor arrays and correct the abnormal data in real time. Evaluations on real-world datasets indicate that the strategy has high performance of fault detection, isolation, and data recovery. Furthermore, our method has low computation complexity and low storage resource occupation. The board-level verification on CC1350 shows that the average calculation time and running power consumption of the algorithm are 0.28 ms and 9.884 mW. The proposed strategy can be deployed on most resource-limited IoT devices to improve the reliability of gas sensing systems.
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http://dx.doi.org/10.3390/s22124315DOI Listing
June 2022

Analysis of Damping Characteristics of Magnetorheological Damper under Impact Load.

Materials (Basel) 2022 Jun 12;15(12). Epub 2022 Jun 12.

College of Mechanical Engineering, Zhejiang University of Technology, Hangzhou 310014, China.

Compared to magnetorheological fluid, magnetorheological gel has better anti-settling performance and stability. Therefore, magnetorheological gel is suitable for devices that can meet operational requirements in all aspects after long-term storage, such as the anti-recoil application of weapons. To study this in-depth, the mechanism of the influence of magnetorheological gel micro-magnetic-mechanical properties on the macro-output damping mechanics of the damper, a parallel plate model of the mixed flow mode composed of Couette shear flow and Poiseuille pressure flow was established. The theoretical analysis was of the output damping of the damper. Finally, the controllability of the damper under impact load employed magnetorheological gel was preliminarily analyzed. The results indicate that the damping coefficient of the damper increases with the increase of dynamic viscosity ηB of the magnetorheological gel, piston effective cross-sectional area AP, magnetic pole L, and Bingham coefficient Bi. Magnetorheological damper has controllability under impact load and can reach a wide controllable range under the condition under small magnetic field ranging from 0 mT to 131 mT.
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http://dx.doi.org/10.3390/ma15124161DOI Listing
June 2022

Effects of Physicochemical Parameters on Struvite Crystallization Based on Kinetics.

Int J Environ Res Public Health 2022 Jun 12;19(12). Epub 2022 Jun 12.

Resources and Environment Innovation Institute, School of Municipal and Environmental Engineering, Shandong Jianzhu University, Jinan 250101, China.

The precipitation of struvite (MgNHPO·6HO) is considered to be a promising method for the recovery of phosphate from wastewater. In this review, the kinetic models, which are commonly used to explain the process of struvite crystallization, are described. The mixed-suspension mixed-product removal (MSMPR) model is based on the population balance equation (the size-dependent growth model and the size-independent growth model). Thereafter, the first-order kinetic fitting model that aligned with concentration changes in the substrate is summarized. Finally, the several physical and chemical factors that affected the efficiency of struvite crystallization are determined. The supersaturation ratio, which is seen as the driving force of struvite crystallization, is the main factor that influences crystallization; however, it cannot be used in practical applications of engineering because it is indirectly associated with the following factors: pH, the molar ratio of Mg:N:P, and the interference of foreign impurities. In this study, we present conclusions that should be used to guide further research studies, and encourage the engineering practice of wastewater treatment with struvite precipitation.
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http://dx.doi.org/10.3390/ijerph19127204DOI Listing
June 2022

Mitochondria-Targeting Polymer Micelle of Dichloroacetate Induced Pyroptosis to Enhance Osteosarcoma Immunotherapy.

ACS Nano 2022 Jun 23. Epub 2022 Jun 23.

Key Laboratory of Smart Biomaterials of Zhejiang Province, College of Chemical and Biological Engineering of Zhejiang University, Hangzhou, Zhejiang 310027, PR China.

Pyroptosis has been reported to improve the immunosuppressive tumor microenvironment and may be a strategy to enhance osteosarcoma treatment. The extent to which modulation of mitochondria could induce tumor pyroptosis to enhance immunotherapy has not been characterized. We synthesized a mitochondria-targeting polymer micelle (OPDEA-PDCA), in which poly[2-(-oxide-,-diethylamino)ethyl methacrylate] (OPDEA) was used to target mitochondria and the conjugated dichloroacetate (DCA) was used to inhibit pyruvate dehydrogenase kinase 1 (PDHK1). This conjugate induced pyroptosis through initiation of mitochondrial oxidative stress. We found that OPDEA-PDCA targeted mitochondria and induced mitochondrial oxidative stress through the inhibition of PDHK1, resulting in immunogenic pyroptosis in osteosarcoma cell lines. Moreover, we showed that OPDEA-PDCA could induce secretion of soluble programmed cell death-ligand 1 (PD-L1) molecule. Therefore, combined therapy with OPDEA-PDCA and an anti-PD-L1 monoclonal antibody significantly suppressed proliferation of osteosarcoma with prolonged T cell activation. This study provided a strategy to initiate pyroptosis through targeted modulation of mitochondria, which may promote enhanced antitumor efficacy in combination with immunotherapy.
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http://dx.doi.org/10.1021/acsnano.2c00192DOI Listing
June 2022

CRISPR-mediated MECOM depletion retards tumor growth by reducing cancer stem cell properties in lung squamous cell carcinoma.

Mol Ther 2022 Jun 21. Epub 2022 Jun 21.

Department of Thoracic Surgery II, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Peking University Cancer Hospital and Institute, Beijing 100142, China. Electronic address:

Targeted therapy for lung squamous cell carcinoma (LUSC) remains a challenge due to the lack of robust targets. Here, we identified MECOM as a candidate of therapeutic target for LUSC by screening 38 genes that were commonly amplified in three pairs of primary tumors and patient-derived xenografts (PDX) using a clustered regularly interspaced short palindromic repeats (CRISPR)-mediated approach. High MECOM expression levels were associated with poor prognosis. Forced expression of MECOM in LUSC cell lines promoted cancer stem cells (CSC) properties, and its knockout inhibited CSC phenotypes. Furthermore, systemic delivery of CRISPR-mediated MECOM depletion cassette using adenovirus with an adaptor, which is composed of a single-chain fragment variable (scFv) against epithelial cell adhesion molecules (EpCAM) fused to the ectodomain of coxsackievirus and adenovirus receptor, and a protector, which is consisted of the scFv connected to the hexon symmetry of the adenovirus, could specifically target subcutaneous and orthotopic LUSC and retard the tumor growth. Together, this study could provide a novel therapeutic strategy for LUSC with high efficacy and specificity.
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http://dx.doi.org/10.1016/j.ymthe.2022.06.011DOI Listing
June 2022

Decoding lymphomyeloid divergence and immune hyporesponsiveness in G-CSF-primed human bone marrow by single-cell RNA-seq.

Cell Discov 2022 Jun 22;8(1):59. Epub 2022 Jun 22.

State Key Laboratory of Proteomics, Academy of Military Medical Sciences, Academy of Military Sciences, Beijing, China.

Granulocyte colony-stimulating factor (G-CSF) has been widely used to mobilize bone marrow hematopoietic stem/progenitor cells for transplantation in the treatment of hematological malignancies for decades. Additionally, G-CSF is also accepted as an essential mediator in immune regulation, leading to reduced graft-versus-host disease following transplantation. Despite the important clinical roles of G-CSF, a comprehensive, unbiased, and high-resolution survey into the cellular and molecular ecosystem of the human G-CSF-primed bone marrow (G-BM) is lacking so far. Here, we employed single-cell RNA sequencing to profile hematopoietic cells in human bone marrow from two healthy donors before and after 5-day G-CSF administration. Through unbiased bioinformatics analysis, our data systematically showed the alterations in the transcriptional landscape of hematopoietic cells in G-BM, and revealed that G-CSF-induced myeloid-biased differentiation initiated from the stage of lymphoid-primed multipotent progenitors. We also illustrated the cellular and molecular basis of hyporesponsiveness of T cells and natural killer (NK) cells caused by G-CSF stimulation, including the potential direct mechanisms and indirect regulations mediated by ligand-receptor interactions. Taken together, our data extend the understanding of lymphomyeloid divergence and potential mechanisms involved in hyporesponsiveness of T and NK cells in human G-BM, which might provide basis for optimization of stem cell transplantation in hematological malignancy treatment.
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http://dx.doi.org/10.1038/s41421-022-00417-yDOI Listing
June 2022

Catastrophe control of aphid populations model.

Math Biosci Eng 2022 May;19(7):7122-7137

State Key Laboratory of Crop Stress Biology in Arid Areas, School of Plant Protection, Northwest A and F University, Yangling 712100, China.

Considering the effect of the natural enemy on aphid populations, the corresponding model with delay is built. The model is analyzed using the qualitative theory of differential equations and catastrophe theory etc. For the outbreak phenomenon of aphid populations, the corresponding management model is proposed and the catastrophe controller is designed to keep the system in a virtuous cycle by means of the qualitative theory of impulsive differential equations. In the mean time, some simulations are carried to prove the results. The paper not only provides a new method for catastrophe control but also expands the application fields of catastrophe control.
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http://dx.doi.org/10.3934/mbe.2022336DOI Listing
May 2022

[Effects of CO concentration and soil water content on short-term water-use efficiency at whole-plant level].

Ying Yong Sheng Tai Xue Bao 2022 Jun;33(6):1505-1510

China Institute of Water Resources and Hydropower Research, Beijing 100048, China.

Uncovering the variations of short-term water-use efficiency (WUE) at whole-plant level in response to CO concentration () and soil water content (SWC) can improve the understanding of plant survival strategies under climate change. In this study, saplings were cultured in simulated climate chambers.There were totally 15 treatments, including of 400 (), 600 () and 800 () μmol·mol and SWC of 35%-45% field water holding capacity (FC), 50%-60%FC, 60%-70%FC, 70%-80%FC and 95%-100%FC. The WUE was measured by mini-lysimeters, weighting method, and static assimilation chamber. The results showed that both daytime (0.12-1.87 mol·h) and nighttime transpiration rates (0.01-0.16 mol·h) at whole-plant level reached the maximum at ×70%-80%FC, while the whole-plant daytime net photosynthetic rate (2.12-22.10 mmol·h) reached the maximum at ×70%-80%FC. In contrast, nighttime respiration rate (0.84-4.41 mmol·h) increased with increasing SWC, but decreased with increasing of , reaching the maximum at ×95%-100%FC. For WUE (5.37-24.35 mmol·mol), it reached the maximum at ×50%-60%FC, indicating that plants could use less water and fixed more carbon by adjusting adaptation strategies under high and drought conditions. In addition, leaf instantaneous water-use efficiency was a good predictor of WUE when the canopy structure was similar.
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http://dx.doi.org/10.13287/j.1001-9332.202206.002DOI Listing
June 2022

Silk Fibroin/Hydroxyapatite Coating Improved Osseointegration of Porous Titanium Implants under Diabetic Conditions via Activation of the PI3K/Akt Signaling Pathway.

ACS Biomater Sci Eng 2022 Jun 20. Epub 2022 Jun 20.

Department of Orthopedics of General Hospital of Northern Theater Command, Shenyang 110016, Liaoning Province, China.

The application of three-dimensional printed porous titanium implants (TIs) is compromised in patients suffering from diabetes mellitus (DM), which disturbs the normal process of implant osseointegration, resulting in fixation failure. It was possibly because of reactive oxygen species (ROS) overproduction at the bone-implant interface. A silk fibroin-based hydroxyapatite (SF/HA) hybrid material emerged as a novel biological material for accelerating new bone formation. We proposed that the SF/HA hybrid coated titanium implant (SHT) could mitigate DM-mediated impaired osseointegration, which had never been reported previously. To test this assumption and further elucidate the mechanisms, primary rabbit osteoblasts were seeded on TIs or SHTs and cultured with normal serum, diabetic serum (DS), DS + N-acetyl-L-cysteine (NAC) (a potent ROS inhibitor), and DS + LY294002 (a specific PI3K/Akt inhibitor) for osteoblast behavior examinations. An animal study was performed on diabetic rabbits implanted with the two kinds of implants for osseointegration tests. DM-mediated ROS overproduction caused osteoblastic biological dysfunctions and apoptotic injury, associated with suppression of PI3K/Akt signaling in osteoblasts cultured on a TI substrate. Of note, the SHT substrate significantly suppressed ROS overproduction under diabetic conditions, improved osteoblast functional recovery including ameliorative osteoblast adhesion and morphology, improved cellular proliferation and differentiation, and abrogated apoptosis, which exhibited the same effect as NAC administration on the TI. The results were further corroborated by enhanced osteogenesis and osseointegration of SHTs in diabetic rabbits. Moreover, the aforesaid promotive effects afforded by the SF/HA coating were totally abolished with administration of LY294002 for blocking PI3K/Akt signaling. The above results collectively demonstrated that the SF/HA hybrid coating significantly ameliorated DM-mediated impaired osseointegration of the TI via reactivation of the ROS-mediated PI3K/Akt signaling pathway. The hybrid coating elicited a novel surface biofunctionalization strategy to attain favorable clinical performance of TI in diabetics.
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http://dx.doi.org/10.1021/acsbiomaterials.2c00023DOI Listing
June 2022

Quantitative assessment of the relative contributions of climate change and human activities to NPP changes in the Southwest Karst area of China.

Environ Sci Pollut Res Int 2022 Jun 20. Epub 2022 Jun 20.

College of Geomatics and Geoinformation, Guilin University of Technology, Guilin, 541006, Guangxi Province, China.

Net primary production (NPP) is an essential component of the terrestrial carbon cycle and an essential factor of ecological processes. In global change research, it was the core content to study the driving forces of NPP change. In this paper, we focused on the Southwest Karst area of China and analyzed the response mechanisms of NPP to topography, land-use types, climatic change, and human activities. Our results showed that (1) changes in elevation and slope lead to significant differences in the spatial distribution of NPP. With the increase of elevation and slope, NPP first increased and then decreased, their critical values were 2000 m and 15°, respectively. (2) NPP varied significantly among different land-use types. The average NPP of the forest was the highest, and the average NPP of cultivated land increased fastest. (3) Temperature and precipitation had the most substantial influence on NPP, both of them promoted the increase of NPP, and the effect of temperature was more obvious in the Southwest Karst area. (4) Ecological engineering significantly promoted the change of NPP, while animal husbandry significantly inhibited the change of NPP. (5) There were significant spatial differences in the driving effects and corresponding contributions of climatic change and human activities; both of them promoted the increase of NPP in the Southwest Karst area of China. Under climatic change and human activities, NPP increased by 1.24 gC·m·year and 2.29 gC·m·year, respectively. The contributions rates of climatic change and human activities separately accounted for 35% and 65%. The contribution of human activities on NPP was much higher than that of climatic change in the Southwest Karst area, and the results suggested that we should focus on the role of human activities on NPP change.
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http://dx.doi.org/10.1007/s11356-022-21433-1DOI Listing
June 2022

Extreme Low-Temperature Stress Affects Nutritional Quality of Amino Acids in Rice.

Front Plant Sci 2022 2;13:905348. Epub 2022 Jun 2.

Key Laboratory for Crop System Analysis and Decision Making, Jiangsu Key Laboratory for Information Agriculture, National Engineering and Technology Center for Information Agriculture, Engineering Research Center of Smart Agriculture, Jiangsu Collaborative Innovation Center for Modern Crop Production, Ministry of Education, Ministry of Agriculture, Nanjing Agricultural University, Nanjing, China.

Global climate change has increased the frequency of extreme climate events, and their effects on the nutritional quality, especially on amino acids in rice, have not been quantified. The data from a 3-year low temperature stress (LTS) experiment including two rice varieties (Huaidao 5 and Nanjing 46), seven minimum/maximum temperature levels (one optimal 21/27°C and six LTS levels from 17/23 to 6/12°C), and three LTS durations (3, 6, and 9 days) after flowering, revealed significant interactive effects of LTS at different stages, durations, and temperature levels on the content and accumulation of amino acids. LTS increased rice total amino acid content, while decreasing its accumulation, with higher sensitivities to LTS at the flowering stage than at the grain filling stage. In most treatments, the lysine (the first limiting amino acid) and phenylalanine content were increased under LTS at early and peak flowering stages but decreased at the grain filling stage in both varieties, and only leucine content was increased at all three stages after flowering, while the content of other essential amino acids differed among the two varieties. With an increase of 1°C·d per day in the accumulated cold degree days, the relative content of the essential amino acids was increased by 0.01-0.41%, depending on the rice variety and growth stage. Our results suggest that LTS can improve nutritional quality of amino acids of rice grains in terms of amino acids content, especially at flowering stage. These results provide critical insights for assessing the potential impact of extreme climates on the nutrient quality of rice under future climate change.
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http://dx.doi.org/10.3389/fpls.2022.905348DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9201379PMC
June 2022

Recent advances in porous nanomaterials-based drug delivery systems for cancer immunotherapy.

J Nanobiotechnology 2022 Jun 14;20(1):277. Epub 2022 Jun 14.

The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, 430072, China.

Cancer immunotherapy is a novel therapeutic regimen because of the specificity and durability of immune modulations to treat cancers. Current cancer immunotherapy is limited by some barriers such as poor response rate, low tumor specificity and systemic toxicities. Porous nanomaterials (PNMs) possess high loading capacity and tunable porosity, receiving intense attention in cancer immunotherapy. Recently, novel PNMs based drug delivery systems have been employed in antitumor immunotherapy to enhance tissue or organ targeting and reduce immune-related adverse events. Herein, we summarize the recent progress of PNMs including inorganic, organic, and organic-inorganic hybrid ones for cancer immunotherapy. The design of PNMs and their performance in cancer immunotherapy are discussed in detail, with a focus on how those designs can address the challenges in current conventional immunotherapy. Lastly, we present future directions of PNMs for cancer immunotherapy including the challenges and research gaps, providing new insights about the design of PNMs for efficient cancer immunotherapy with better performance as powerful weapons against tumors. Finally, we discussed the relevant challenges that urgently need to be addressed in clinical practice, coupled with corresponding solutions to these problems.
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http://dx.doi.org/10.1186/s12951-022-01489-4DOI Listing
June 2022

Different antioxidant regulation mechanisms in response to aluminum-induced oxidative stress in Eucalyptus species.

Ecotoxicol Environ Saf 2022 Jun 10;241:113748. Epub 2022 Jun 10.

State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, Guangxi Key Laboratory of Forest Ecology and Conservation, Forestry College, Guangxi University, Nanning, Guangxi, China. Electronic address:

Forest ecosystems play an important role in environmental protection and maintaining ecological balance. Understanding the physiological mechanisms of tree species response to aluminum (Al) toxic is crucial to reveal the main causes of plantation decline in acid rain area. As an important afforestation tree species in tropical and subtropical areas, Eucalyptus has high economic value and plays crucial ecological roles. However, continuous fertilization and acid precipitation can exacerbate soil acidification and increase soil active Al, which has a significant negative impact on Eucalyptus growth. Hence, species and genotypes with high Al resistance are required to solve the problem of Al toxicity of acidic soils for sustainable forest production. In this study, E. urophylla was better adapted to Al stress than E. grandis or E. tereticornis; its high Al resistance was attributed to greater antioxidant enzyme activity and non-enzymatic antioxidant content, and a lower degree of membrane lipid peroxidation than E. grandis or E. tereticornis. The differences in adaptability among the three pure species were attributed to their distinct habitats. Eucalyptus urophylla × E. grandis inherited the outstanding adaptability to Al stress from its maternal species (E. urophylla), indicating that Al tolerance is highly heritable and can be selected in Eucalyptus breeding. Our results indicated that the response of Eucalyptus to Al stress may fluctuate according to the time under stress, and might be related to dynamic changes in ROS elimination and accumulation.
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http://dx.doi.org/10.1016/j.ecoenv.2022.113748DOI Listing
June 2022

Effect of autologous NK cell immunotherapy on advanced lung adenocarcinoma with EGFR mutations.

Precis Clin Med 2019 Dec 22;2(4):235-245. Epub 2019 Nov 22.

Department of Biotherapy and Oncology, Shenzhen Luohu People's Hospital, The Third Affiliated Hospital (The Affiliated Luohu Hospital) of Shenzhen University, Shenzhen 518001, China.

This study investigated the efficiency of natural killer (NK) cell immunotherapy on non-small cell lung cancer with and without EGFR mutations in order to evaluate the response rate (RR) and progression-free survival (PFS). Among the 48 patients recruited, 24 were clinically confirmed to be EGFR mutation positive. The study group was treated with autologous NK cell immunotherapy. Comparisons of the lymphocyte number, serum tumour-related biomarkers, circulating tumour cells (CTC), Karnofsky Performance Status (KPS) and survival curves were carried out before and after NK cell immunotherapy. The safety and short-term effects were evaluated, followed by median PFS and RR assessments. The serum CEA and CA125 values were found lower in the NK cell therapy group than that of the non-NK treatment group (). The χ test showed a 75% RR of the study group A, significantly higher than that of the control group B (16.7%; ). The RR of groups C (58.3%) and D (41.7%) were not statistically significant. The values of the 4 groups were 0.012, 0.012, 0.166 and 1 from group A to group D, respectively. The median PFS was 9 months in EGFR mutation positive group undergoing NK cell infusion interference. By evaluating the changes in immune function, tumour biomarkers, CTC, KPS and PFS, we demonstrated that NK cell therapy had better clinical therapeutic effects on EGFR mutation-positive lung adenocarcinoma.
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http://dx.doi.org/10.1093/pcmedi/pbz023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8985770PMC
December 2019

Expansion of CD3CD8PD1 T lymphocytes and TCR repertoire diversity predict clinical responses to adoptive cell therapy in advanced gastric cancer.

Am J Cancer Res 2022 15;12(5):2203-2215. Epub 2022 May 15.

Department of Medical Oncology, Beijing Key Laboratory for Therapeutic Cancer Vaccines, Capital Medical University Cancer Center, Beijing Shijitan Hospital, Capital Medical University Beijing 100038, China.

The adoptive cell therapy (ACT) and delivery of ex vivo activated cellular products, such as dendritic cells (DCs), NK cells, and T cells, have shown promise for the treatment of gastric cancer (GC). However, it is unknown which cells can improve patient survival. This study was focused on the antitumour activity of a subset of these cellular products and their relationships with clinical outcomes. Nineteen patients were enrolled at the Capital Medical University Cancer Center, Beijing Shijitan Hospital, from June 1, 2013, to May 30, 2016. CD8PD1 T-cell sorting was carried out using flow cytometry, and the T-cell receptor (TCR) repertoire during ex vivo expansion for 15 days was analyzed by next-generation sequencing. After 15 days of culture, the number of CD8 T cells had increased significantly, and the number of CD4 T cells had increased correspondingly. After ex vivo expansion, CD8 T cells exhibited significantly enhanced expression of PD-1, LAG-3, and TIM-3 but not 4-1BB. Survival analysis showed that patients with a pro/pre value of CD8PD-1 T cells >2.4 had significantly favorable overall survival (OS) (median OS time, 248 days versus 96 days, P=0.02) and progression-free survival (PFS) (median PFS time, 183 days vs. 77 days, P=0.002). The sorted CD8PD-1 T cells displayed enhanced antitumor activity and increased IFN-γ secretion after coculture with autologous tumor cell lines. TCR repertoire diversity was decreased after ex vivo expansion, which decreased the Shannon index and increased the clonality value. The prognosis of patients was significantly improved and was associated with the extent of CD8PD-1 T-cell expansion. In summary, this study showed that after ex vivo expansion for 15 days, CD8PD-1 T cells could be identified as tumor-reactive cells in patients treated for GC. Changing TCR species can predict the extent of CD3CD8PD1 T-cell growth and the effect of ACT treatment.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9185603PMC
May 2022

Comprehensive genomic analysis of primary malignant melanoma of the esophagus reveals similar genetic patterns compared with epithelium-associated melanomas.

Mod Pathol 2022 Jun 10. Epub 2022 Jun 10.

Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Thoracic Surgery II, Peking University Cancer Hospital & Institute, Beijing, 100142, China.

Primary malignant melanoma of the esophagus (PMME) is an exceedingly rare disease with a poor prognosis. The etiology of PMME remains largely unknown and genetic characteristics are yet to be clarified, essential for identifying potential therapeutic targets and defining treatment guidelines. Here, we performed whole-exome sequencing on 47 formalin-fixed paraffin-embedded specimens from 18 patients with PMME, including 23 tumor samples, 6 metastatic lymph nodes, and 18 tumor-adjacent normal tissues. The genomic features of PMME were comprehensively characterized, and comparative genomic analysis was further performed between these specimens and 398 skin cutaneous melanomas (SKCM), 67 non-esophagus mucosal melanomas (NEMM), and 79 uveal melanomas (UVM). In the PMME cohort, recurrently mutated driver genes, such as MUC16, RANBP2, NRAS, TP53, PTPRT, NF1, MUC4, KMT2C, and BRAF, were identified. All RANBP2 mutations were putatively deleterious, and most affected samples had multipoint mutations. Furthermore, RANBP2 showed parallel evolution by multiregional analysis. Whole-genome doubling was an early truncal event that occurred before most driver mutations, except for in TP53. An ultraviolet radiation-related mutational signature, SBS38, was identified as specific to epithelial melanomas and could predict inferior survival outcomes in both PMME and SKCM patients. Comparing the mutational and copy number landscapes between PMME and other subtypes of melanoma revealed that PMME has a similar genomic pattern and biological characteristics to SKCM. In summary, we comprehensively defined the key genomic aberrations and mutational processes driving PMME and suggested for the first time that PMME may share similar genomic patterns with SKCM; therefore, patients with rare melanomas, such as PMME, may benefit from the current treatment used for common cutaneous melanoma.
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http://dx.doi.org/10.1038/s41379-022-01116-5DOI Listing
June 2022

Bioinformatics identifies predictors of arteriovenous fistula maturation.

J Vasc Access 2022 Jun 10:11297298221102298. Epub 2022 Jun 10.

The Vascular Biology and Therapeutics Program, Yale School of Medicine, New Haven, CT, USA.

Background: Arteriovenous fistulae (AVF) are the preferred access for hemodialysis but still have poor rates of maturation and patency limiting their clinical use. The underlying mechanisms of venous remodeling remain poorly understood, and only limited numbers of unbiased approaches have been reported.

Methods: Biological Gene Ontology (GO) term enrichment analysis and differentially expressed genes (DEG) analysis were performed for three AVF datasets. A microRNA enrichment analysis and L1000CDS query were performed to identify factors predicting AVF patency.

Results: The inflammatory and immune responses were activated during both early and late phases of AVF maturation, with upregulation of neutrophil and leukocyte regulation, cytokine production, and cytokine-mediated signaling. In men with failed AVF, negative regulation of myeloid-leukocyte differentiation and regulation of macrophage activation were significantly upregulated. Compared to non-diabetic patients, diabetic patients had significantly reduced immune response-related enrichment such as cell activation in immune response, regulation of immune-effector process, and positive regulation of defense response; in addition, diabetic patients showed no enrichment of the immune response-regulating signaling pathway.

Conclusions: These data show coordinated, and differential regulation of genes associated with AVF maturation, and different patterns of several pathways are associated with sex differences in AVF failure. Inflammatory and immune responses are activated during AVF maturation and diabetes may impair AVF maturation by altering these responses. These findings suggest several novel molecular targets to improve sex specific AVF maturation.
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http://dx.doi.org/10.1177/11297298221102298DOI Listing
June 2022

A Kinetic Model for Anaerobic Digestion and Biogas Production of Plant Biomass under High Salinity.

Int J Environ Res Public Health 2022 Jun 6;19(11). Epub 2022 Jun 6.

Faculty of Environmental Engineering, The University of Kitakyushu, 1-1, Hibikino, Wakamatsu, Kitakyushu 808-0135, Japan.

The aim of this study is to evaluate the anaerobic digestion and biogas production of plant biomass under high salinity by adopting a theoretical and technical approach for saline plant-biomass treatment. Two completely mixed lab-scale mesophilic reactors were operated for 480 days. In one of them, NaCl was added and the sodium ion concentration was maintained at 35.8 g-Na·L, and the organic loading rate was 0.58-COD·L·d-1.5 g-COD·L·d; the other added NaSO-NaHCO and kept the sodium ion concentration at 27.6 g-Na·L and the organic loading rate at 0.2 g-COD·L·d-0.8 g-COD·L·d. The conversion efficiencies of the two systems (COD to methane) were 66% and 54%, respectively. Based on the sulfate-reduction reaction and the existing anaerobic digestion model, a kinetic model comprising 12 types of soluble substrates and 16 types of anaerobic microorganisms was developed. The model was used to simulate the process performance of a continuous anaerobic bioreactor with a mixed liquor suspended solids (MLSS) concentration of 10 g·L-40 g·L. The results showed that the NaCl system could receive the influent up to a loading rate of 0.16 kg-COD/kg-MLSS·d without significant degradation of the methane conversion at 66%, while the NaSO-NaHCO system could receive more than 2 kg-COD·kg-MLSS·d, where 54% of the fed chemical oxygen demand (COD) was converted into methane and another 12% was observed to be sulfide.
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http://dx.doi.org/10.3390/ijerph19116943DOI Listing
June 2022

Structural and functional connectivity abnormalities of the default mode network in patients with Alzheimer's disease and mild cognitive impairment within two independent datasets.

Methods 2022 Jun 6;205:29-38. Epub 2022 Jun 6.

School of Artificial Intelligence, Beijing University of Posts and Telecommunications, Beijing, China. Electronic address:

Alzheimer's disease (AD) is a chronic neurodegenerative disease characterized by progressive dementia, and amnestic mild cognitive impairment (aMCI) has been defined as a transitional stage between normal aging and AD. Accumulating evidence has shown that altered functional connectivity (FC) and structural connectivity (SC) in the default mode network (DMN) is the prominent hallmarks of AD. However, the relationship between the changes in SC and FC of the DMN is not yet clear. In the present study, we derived the FC and SC matrices of the DMN with functional magnetic resonance imaging (fMRI) and diffusion-weighted imaging (DWI) data and further assessed FC and SC abnormalities within a discovery dataset of 120 participants (39 normal controls, 34 patients with aMCI and 47 patients with AD), as well as a replication dataset of 122 participants (43 normal controls, 37 patients with aMCI and 42 patients with AD). Disrupted SC and FC were found among DMN components (e.g., the posterior cingulate cortex (PCC), medial prefrontal cortex (mPFC), and hippocampus) in patients in the aMCI and AD groups in the discovery dataset; most of the disrupted connections were also identified in the replication dataset. More importantly, some SC and FC elements were significantly correlated with the cognitive ability of patients with aMCI and AD. In addition, we found structural-functional decoupling between the PCC and the right hippocampus in patients in the aMCI and AD groups. These findings of the alteration of DMN connectivity in neurodegenerative cohorts deepen our understanding of the pathophysiological mechanisms of AD.
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http://dx.doi.org/10.1016/j.ymeth.2022.06.001DOI Listing
June 2022

Unexpected response of nitrogen deposition to nitrogen oxide controls and implications for land carbon sink.

Nat Commun 2022 Jun 6;13(1):3126. Epub 2022 Jun 6.

State Key Joint Laboratory of Environmental Simulation and Pollution Control, College of Environmental Sciences and Engineering, Peking University, Beijing, 100871, China.

Terrestrial ecosystems in China receive the world's largest amount of reactive nitrogen (N) deposition. Recent controls on nitrogen oxides (NO = NO + NO) emissions in China to tackle air pollution are expected to decrease N deposition, yet the observed N deposition fluxes remain almost stagnant. Here we show that the effectiveness of NO emission controls for reducing oxidized N (NO = NO + its oxidation products) deposition is unforeseen in Eastern China, with one-unit reduction in NO emission leading to only 55‒76% reductions in NO-N deposition, as opposed to the high effectiveness (around 100%) in both Southern China and the United States. Using an atmospheric chemical transport model, we demonstrate that this unexpected weakened response of N deposition is attributable to the enhanced atmospheric oxidizing capacity by NO emissions reductions. The decline in N deposition could bear a penalty on terrestrial carbon sinks and should be taken into account when developing pathways for China's carbon neutrality.
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http://dx.doi.org/10.1038/s41467-022-30854-yDOI Listing
June 2022

Study on the technology of efficient extraction of eleutheroside E from Acanthopanax senticosus by green solvent DES.

Phytochem Anal 2022 Jun 6. Epub 2022 Jun 6.

College of Pharmacy, Jiamusi University, Jiamusi, China.

Objectives: Acanthopanax senticosus (Rupr. & Maxim.) Harms is a medicinal and edible plant which is clinically used for the recovery and treatment of cardiovascular and central diseases. As a characteristic active pharmaceutical ingredient of Acanthopanax senticosus, eleutheroside E is the core of the therapeutic effect. Organic solvent extraction has low selectivity, low extraction rate, difficulty in separation and purification and safety risks. The purpose of this study was to extract the effective component of Acanthopanax senticosus with a new green solvent.

Methods: In this article, two kinds of deep eutectic solvents (DESs) (DES-1 and DES-2) were synthesised by heating and stirring methods. Eleutheroside E was extracted by ultrasonic extraction with two kinds of DES as extractants and quantitatively analysed by Orbitrap-tandem mass spectrometry (MS/MS).

Results: The main results showed that the initial polarity of the DES was similar to that of 60 to 80% ethanol and hydrogen bond donors were the main factors affecting the polarity of DES. In the test, the viscosity of DES was higher than that of ethanol, and even the addition of a small amount of water (10%) caused intermolecular hydrogen bond disruption and redistribution of the solvent, resulting in a significant decrease in solvent viscosity. The solvents in the test group were stable after standing at 5°C in the dark for 100 days. The extraction rate of eleutheroside E by DES solvent was 5-6 times higher than that by ethanol. DES-1 and DES-2 can efficiently extract eleutheroside E.

Conclusion: This study developed a new method for the application of the green extraction of eleutheroside E with certain practical significance.
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http://dx.doi.org/10.1002/pca.3144DOI Listing
June 2022

Chronic Kidney Disease and Cancer: Inter-Relationships and Mechanisms.

Front Cell Dev Biol 2022 18;10:868715. Epub 2022 May 18.

Department of Nephrology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.

Chronic kidney disease (CKD) has been recognized as an increasingly serious public health problem globally over the decades. Accumulating evidence has shown that the incidence rate of cancer was relatively higher in CKD patients than that in general population, which, mechanistically, may be related to chronic inflammation, accumulation of carcinogenic compounds, oxidative stress, impairment of DNA repair, excessive parathyroid hormone and changes in intestinal microbiota, etc. And in patients with cancer, regardless of tumor types or anticancer treatment, it has been indicated that the morbidity and incidence rate of concomitant CKD was also increased, suggesting a complex inter-relationship between CKD and cancer and arousing increasing attention from both nephrologists and oncologists. This narrative review focused on the correlation between CKD and cancer, and underlying molecular mechanisms, which might provide an overview of novel interdisciplinary research interests and the potential challenges related to the screening and treatment of CKD and cancer. A better understanding of this field might be of help for both nephrologists and oncologists in the clinical practice.
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http://dx.doi.org/10.3389/fcell.2022.868715DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9158340PMC
May 2022

Calibration of miniature air quality detector monitoring data with PCA-RVM-NAR combination model.

Sci Rep 2022 Jun 4;12(1):9333. Epub 2022 Jun 4.

School of Intelligent Manufacturing, Sanmenxia Polytechnic, Sanmenxia, 472000, China.

The development of miniature air quality detectors makes it possible for humans to monitor air quality in real time and grid. However, the accuracy of measuring pollutants by miniature air quality detectors needs to be improved. In this paper, the PCA-RVM-NAR combined model is proposed to calibrate the measurement accuracy of the miniature air quality detector. First, correlation analysis is used to find out the main factors affecting pollutant concentrations. Second, principal component analysis is used to reduce the dimensionality of these main factors and extract their main information. Thirdly, taking the extracted principal components as independent variables and the observed values of pollutant concentrations as dependent variables, a PCA-RVM model is established by the relevance vector machine. Finally, the nonlinear autoregressive neural network is used to correct the error and finally complete the establishment of the PCA-RVM-NAR model. Root mean square error, goodness of fit, mean absolute error and relative mean absolute percent error are used to compare the calibration effect of PCA-RVM-NAR model and other commonly used models such as multiple linear regression model, support vector machine, multilayer perceptron neural network and nonlinear autoregressive models with exogenous input. The results show that, no matter which pollutant, the PCA-RVM-NAR model achieves better calibration results than other models in the four indicators. Using this model to correct the data of the miniature air quality detector can improve its accuracy by 77.8-93.9%.
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http://dx.doi.org/10.1038/s41598-022-13531-4DOI Listing
June 2022

Tirzepatide Once Weekly for the Treatment of Obesity.

N Engl J Med 2022 Jun 4. Epub 2022 Jun 4.

From the Section of Endocrinology and Metabolism, Department of Medicine, and the Section of Pediatric Endocrinology, Department of Pediatrics, Yale University School of Medicine, New Haven, CT (A.M.J.); the Comprehensive Weight Control Center, Division of Endocrinology, Diabetes, and Metabolism, Weill Cornell Medicine, New York (L.J.A.); Eli Lilly, Indianapolis (N.N.A., S.Z., B.L., M.C.B., A.S.); York University, McMaster University, and Wharton Weight Management Clinic - all in Toronto (S.W.); Intend Research, Norman, OK (L.C.); Centro Paulista De Investigação Clínica (Cepic), Sao Paulo (B.A.); and Tokyo-Eki Center-Building Clinic, Tokyo (A.K.).

Background: Obesity is a chronic disease that results in substantial global morbidity and mortality. The efficacy and safety of tirzepatide, a novel glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 receptor agonist, in people with obesity are not known.

Methods: In this phase 3 double-blind, randomized, controlled trial, we assigned 2539 adults with a body-mass index (BMI; the weight in kilograms divided by the square of the height in meters) of 30 or more, or 27 or more and at least one weight-related complication, excluding diabetes, in a 1:1:1:1 ratio to receive once-weekly, subcutaneous tirzepatide (5 mg, 10 mg, or 15 mg) or placebo for 72 weeks, including a 20-week dose-escalation period. Coprimary end points were the percentage change in weight from baseline and a weight reduction of 5% or more. The treatment-regimen estimand assessed effects regardless of treatment discontinuation in the intention-to-treat population.

Results: At baseline, the mean body weight was 104.8 kg, the mean BMI was 38.0, and 94.5% of participants had a BMI of 30 or higher. The mean percentage change in weight at week 72 was -15.0% (95% confidence interval [CI], -15.9 to -14.2) with 5-mg weekly doses of tirzepatide, -19.5% (95% CI, -20.4 to -18.5) with 10-mg doses, and -20.9% (95% CI, -21.8 to -19.9) with 15-mg doses and -3.1% (95% CI, -4.3 to -1.9) with placebo (P<0.001 for all comparisons with placebo). The percentage of participants who had weight reduction of 5% or more was 85% (95% CI, 82 to 89), 89% (95% CI, 86 to 92), and 91% (95% CI, 88 to 94) with 5 mg, 10 mg, and 15 mg of tirzepatide, respectively, and 35% (95% CI, 30 to 39) with placebo; 50% (95% CI, 46 to 54) and 57% (95% CI, 53 to 61) of participants in the 10-mg and 15-mg groups had a reduction in body weight of 20% or more, as compared with 3% (95% CI, 1 to 5) in the placebo group (P<0.001 for all comparisons with placebo). Improvements in all prespecified cardiometabolic measures were observed with tirzepatide. The most common adverse events with tirzepatide were gastrointestinal, and most were mild to moderate in severity, occurring primarily during dose escalation. Adverse events caused treatment discontinuation in 4.3%, 7.1%, 6.2%, and 2.6% of participants receiving 5-mg, 10-mg, and 15-mg tirzepatide doses and placebo, respectively.

Conclusions: In this 72-week trial in participants with obesity, 5 mg, 10 mg, or 15 mg of tirzepatide once weekly provided substantial and sustained reductions in body weight. (Supported by Eli Lilly; SURMOUNT-1 ClinicalTrials.gov number, NCT04184622.).
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http://dx.doi.org/10.1056/NEJMoa2206038DOI Listing
June 2022

Probiotic-fermented Pueraria lobata (Willd.) Ohwi alleviates alcoholic liver injury by enhancing antioxidant defense and modulating gut microbiota.

J Sci Food Agric 2022 Jun 2. Epub 2022 Jun 2.

College of Food Science, South China Agricultural University, Guangzhou, China.

Background: Pueraria lobata (Willd.) Ohwi (PL) has been used in China to detoxify alcohol and protect the liver for millennia, though its mechanism of liver protection has not been elucidated. However, fermentation is considered to be one of the effective ways to enhance the efficacy of traditional Chinese medicine. The aim of this study was to investigate the hepatoprotective mechanism of probiotic-fermented PL (FPL). Sprague Dawley rats were administered with FPL followed by gavage of alcohol for seven consecutive days; following that, liver injury levels were evaluated in rats.

Results: FPL ameliorated lipid accumulation and inflammation levels in rats. Meanwhile, the levels of ethanol dehydrogenase, acetaldehyde dehydrogenase, and cytochrome P4502E1 were elevated by FPL treatment. It was observed that the levels of catalase, superoxide dismutase, and glutathione peroxidase were elevated, and the expression of nuclear transcriptional factor (erythroid-derived 2)-like 2 (Nrf2) and heme oxygenase-1 genes and proteins were increased by FPL treatment, demonstrating that the Nrf2-mediated signal pathway was activated. Furthermore, FPL restored the composition of the gut microbiota with an increase in the abundances of Firmicutes and Lactobacillus and a decrease in the abundances of Bacteroidota and Akkermansia. Additionally, a strong correlation was found between the gut microbiota and the antioxidant parameters.

Conclusion: The results indicate that FPL possesses an excellent protective effect in alcoholic liver injury. Our findings are beneficial to the development of hepatoprotective nutraceuticals for alcoholics. © 2022 Society of Chemical Industry.
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http://dx.doi.org/10.1002/jsfa.12049DOI Listing
June 2022

CircCEMIP promotes anoikis-resistance by enhancing protective autophagy in prostate cancer cells.

J Exp Clin Cancer Res 2022 Jun 2;41(1):188. Epub 2022 Jun 2.

Department of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.

Background: Circular RNAs (circRNAs) are essential participants in the development and progression of various malignant tumors. Previous studies have shown that cell migration-inducing protein (CEMIP) accelerates prostate cancer (PCa) anoikis resistance (AR) by activating autophagy. This study focused on the effect of circCEMIP on PCa metastasis.

Methods: This study gradually revealed the role of circ_0004585 in PCa anoikis resistance via quantitative real-time PCR (qRT-PCR) analysis, western blotting, pull-down assays, and dual fluorescence reporter assays.

Results: Functionally, circ_0004585 promoted PCa cells invasion and metastasis both in vitro and in vivo. Mechanistically, circ_0004585 directly interacted with miR-1248 to upregulate target gene expression. Furthermore, target prediction and dual-luciferase reporter assays identified transmembrane 9 superfamily member 4 (TM9SF4) as a potential miR-1248 target. Pathway analysis revealed that TM9SF4 activated autophagy to promote PCa cells anoikis resistance via mTOR phosphorylation.

Conclusions: These results demonstrated that circ_0004585 played an oncogenic role during PCa invasion and metastasis by targeting the miR-1248/TM9SF4 axis while providing new insight into therapeutic strategy development for metastatic PCa.
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http://dx.doi.org/10.1186/s13046-022-02381-7DOI Listing
June 2022

Genetic susceptibility to high myopia in Han Chinese population.

Open Life Sci 2022 17;17(1):512-516. Epub 2022 May 17.

College of Life Sciences, Shandong First Medical University & Shandong Academy of Medical Sciences, Tai'an, 271016, China.

High myopia is a common ocular genetic disease in the world. The study sought to investigate the effect of the Insulin-like growth factor-1 (IGF-1) and Matrix metalloproteinase-9 (MMP-9) genes polymorphisms on high myopia in a Han population of China. This study recruited 216 unrelated Han Chinese subjects, including 103 cases with high myopia and 113 controls. Four tagging single nucleotide polymorphisms (SNPs) of and genes were genotyped using the Sequenom MassARRAY method. The chi-square test showed that the family history was significantly correlated with myopia. The SNP genotypes were all in Hardy-Weinberg equilibrium ( > 0.05). Among the four SNPs, there were statistically significant differences in the genotype and allele frequencies of between the groups ( = 0.024). The significant associations of between cases and controls also appeared after Bonferroni multiple correction ( = 0.024). Then, there were significant differences in the genotypes dominant model and codominant model of between groups ( = 0.007 and = 0.004, respectively). showed a significant difference between the cases and the controls in the recessive model ( = 0.037). Our findings indicated that of was associated with myopia in the population. The result suggested gene locus may play a role in myopia.
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http://dx.doi.org/10.1515/biol-2022-0055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9123300PMC
May 2022

Evolving deep convolutional neural networks by IP-based marine predator algorithm for COVID-19 diagnosis using chest CT scans.

J Ambient Intell Humaniz Comput 2022 May 24:1-14. Epub 2022 May 24.

Guiyang Fourth People's Hospital, Guiyang City, Guizhou province China.

This paper proposes an optimal structured deep convolutional neural network (DCNN) based on the marine predator algorithm (MPA) to construct a novel automatic diagnosis platform that may help radiologists identify COVID-19 and non-COVID-19 patients based on CT scan categorization and analysis. The goal is met with the help of three modifications based on the regular MPA. First, a novel encoding scheme based on Internet Protocol (IP) addresses is proposed, followed by introducing an Enfeebled layer to build a variable-length DCNN. Finally, the learning process divides big datasets into smaller chunks that are randomly evaluated. The proposed model is compared to the COVID-CT and SARS-CoV-2 datasets to undertake a complete evaluation. Following that, the performance of the developed model (DCNN-IPMPA) is compared to that of a typical DCNN and seven variable-length models using five well-known comparison metrics, as well as the receiver operating characteristic and precision-recall curves. The results show that the DCNN-IPMPA outperforms other benchmarks, with a final accuracy of 97.21% on the SARS-CoV-2 dataset and 97.94% on the COVID-CT dataset. Also, timing analysis indicates that the DCNN processing time is the best among all benchmarks as expected; however, DCNN-IPMPA represents a competitive result compared to the standard DCNN.
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http://dx.doi.org/10.1007/s12652-022-03901-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9127492PMC
May 2022

Berberine suppresses the migration and invasion of colon cancer cells by inhibition of lipogenesis through modulation of promyelocytic leukemia zinc finger-mediated sterol-regulatory element binding proteins cleavage-activating protein ubiquitination.

J Pharm Pharmacol 2022 May 31. Epub 2022 May 31.

Department of Pharmacy, Nanjing First Hospital, Nanjing Medical University, Nanjing, P. R. China.

Objectives: This study was aimed to explore whether and how berberine suppresses colon cancer cell metastasis via lipid modulation.

Methods: Lipid accumulation was measured by an oil red O staining kit. The expression of proteins and message RNA was detected by Western blot and quantitative real-time PCR. The interaction of sterol-regulatory element-binding proteins cleavage-activating protein (SCAP) with promyelocytic leukaemia zinc finger (PLZF) was confirmed by co-immunoprecipitation assay. Expressions of fatty acid synthase (FASN) and PLZF were knocked down by specific small interfering RNA.

Key Findings: Berberine inhibited the migration and invasion of HCT-8, HCT-116 and HT-29 cells. Moreover, it was observed that berberine decreased lipid droplet accumulation. FASN knockdown abolished the inhibitory effects of berberine on cell migration and invasion. Further investigation revealed that berberine induced the ubiquitination degradation of SCAP. And PLZF interacted with SCAP and promoted its ubiquitination, which was inhibited by berberine treatment. Silence of PLZF impaired the effects of berberine on SCAP ubiquitination and lipogenesis.

Conclusions: Berberine suppressed lipogenesis via promotion of PLZF-mediated SCAP ubiquitination, thereby inhibiting colon cancer cell metastasis.
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http://dx.doi.org/10.1093/jpp/rgac026DOI Listing
May 2022

Perennial Flowering Plants Sustain Natural Enemy Populations in Gobi Desert Oases of Southern Xinjiang, China.

Insects 2022 Apr 20;13(5). Epub 2022 Apr 20.

State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, China.

Natural habitats play crucial roles in biodiversity conservation and shape the delivery of ecosystem services in farming landscapes. By providing diverse resources to foraging natural enemies, they can equally enhance biological pest control. In this study, we described the plant community and foliage-dwelling invertebrate predators within non-crop habitats of the Gobi Desert oases in southern Xinjiang, China. We assessed whether plant-related variables (i.e., species identity, flowering status) and herbivore abundance affect natural enemy identity and abundance. A total of 18 plant species belonging to 18 genera and 10 families were commonly encountered, with (Apocynaceae), (Poaceae), (Asteraceae), and (Tamaricaceae) as the dominant species. Certain plant species () primarily provide shelter, while others offer (floral, non-floral) food resources or alternative prey. Predatory ladybeetles and spiders were routinely associated with these plants and foraged extensively within adjacent field crops. Plant traits and herbivore abundance explained up to 44% (3%-44%) variation in natural enemy community and exhibited consistent, year-round effects. Among all plant species, consistently had a significantly higher abundance of resident natural enemies, except for August 2019. Our study underlines how perennial flowering plants, such as are essential to sustain natural enemy communities and related ecosystem services in arid settings. This work not only informs sustainable pest management initiatives but also shows how non-crop habitats at the periphery of agricultural fields underpin ecological resilience under adverse climatic conditions.
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http://dx.doi.org/10.3390/insects13050399DOI Listing
April 2022
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