Publications by authors named "Binbin Zhang"

136 Publications

Value of preoperative computed tomography for meso-Rex bypass in children with extrahepatic portal vein obstruction.

Insights Imaging 2021 Jul 27;12(1):109. Epub 2021 Jul 27.

Department of Pediatric Surgery, Guangzhou Women and Children's Medical Center, 9 Jinsui Road, Guangzhou, 510623, Guangdong, China.

Background: Extrahepatic portal vein obstruction (EHPVO) is the most important cause of hematemesis in children. Intrahepatic left portal vein and superior mesenteric vein anastomosis, also known as meso-Rex bypass (MRB), is becoming the gold standard treatment for EHPVO. We analyzed the value of preoperative computed tomography (CT) in determining whether MRB is feasible in children with EHPVO.

Results: We retrieved data on 76 children with EHPVO (50 male, 26 female; median age, 5.9 years) who underwent MRB (n = 68) or the Warren procedure (n = 8) from 2013 to 2019 and retrospectively analyzed their clinical and CT characteristics. The Rex recess was categorized into four subtypes (types 1-4) depending on its diameter in CT images. Of all 76 children, 7.9% had a history of umbilical catheterization and 1.3% had leukemia. Sixteen patients (20 lesions) had associated malformations. A total of 72.4% of Rex recesses could be measured by CT, and their mean diameter was 3.5 ± 1.8 mm (range 0.6-10.5 mm). A type 1, 2, 3, and 4 Rex recess was present in 9.2%, 53.9%, 11.8%, and 25.0% of patients, respectively. MRB could be performed in patients with types 1, 2, and 3, but those with type 4 required further evaluation. The sensitivity, specificity, positive predictive value, negative predictive value, and diagnostic accuracy of CT were 100%, 83.8%, 42.1%, 100%, and 85.5%, respectively.

Conclusions: Among the four types of Rex recesses on CT angiography, types 1-3 allow for the performance of MRB.
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http://dx.doi.org/10.1186/s13244-021-01057-8DOI Listing
July 2021

Exosomal miR-21-5p derived from cisplatin-resistant SKOV3 ovarian cancer cells promotes glycolysis and inhibits chemosensitivity of its progenitor SKOV3 cells by targeting PDHA1.

Cell Biol Int 2021 Jul 20. Epub 2021 Jul 20.

Department of Gynecology, People's Hospital Affiliated of Fujian University of Traditional Chinese Medicine, Fuzhou, China.

Ovarian cancer (OC) is a common reason for gynecologic cancer death. Standard treatments of OC consist of surgery and chemotherapy. However, chemoresistance should be considered. Exosomal miR-21-5p has been shown to regulate the chemosensitivity of cancer cells through regulating pyruvate dehydrogenase E1 subunit alpha 1 (PDHA1). However, the role of miR-21-5p/PDHA1 in OC is unclear. The levels of miR-21-5p and PDHA1 in clinical samples and cells were investigated. Exosomes derived from SKOV3/cisplatin (SKOV3/DDP) cells (DDP-Exos) were isolated and used to treat SKOV3 cells to test DDP-Exos effects on SKOV3 cells. Extracellular acidification rate and oxygen consumption rate were tested with a Seahorse analyzer. Cell apoptosis was analyzed by a flow cytometer. PDHA1 was overexpressed and miR-21-5p was silenced in SKOV3 cells to study the underlying mechanism of miR-21-5p in OC. Quantitative real-time PCR and immunoblots were applied to measure gene expression at mRNA and protein levels. The levels of PDHA1 in DDP-resistant SKOV3 or tumor tissues were significantly decreased while the levels of miR-21-5p were remarkably upregulated. miR-21-5p in DDP-Exos was sharply increased compared to that of Exos. Data also indicated that DDP-Exos treatment suppressed the sensitivity of SKOV3 cells to DDP and promoted cell viability and glycolysis of SKOV3 cells through inhibiting PDHA1 by exosomal miR-21-5p. miR-21-5p derived from DDP-resistant SKOV3 OC cells promotes glycolysis and inhibits chemosensitivity of its progenitor SKOV3 cells by targeting PDHA1. Our data highlights the important role of miR-21-5p/PDHA1 axis in OC and sheds light on new therapeutic development.
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http://dx.doi.org/10.1002/cbin.11671DOI Listing
July 2021

Increased thyroid malignancy in patients with primary hyperparathyroidism.

Endocr Connect 2021 Jul 1. Epub 2021 Jul 1.

L Sheng, Department of Thyroid Surgery, Shandong University Qilu Hospital, Jinan, China.

Background: Multiple studies have reported increased incidence of thyroid cancer in patients with primary hyperparathyroidism (PHPT). However, the underlying risk factors of concomitant thyroid cancer in patients with PHPT remain unknown. The primary aim of this study was to examine the records of patients with PHPT to identify characteristics that correlated with the presence of coexisting thyroid nodules, and which may have an implication for the prediction of thyroid cancer.

Methods: Medical records of consecutive patients with PHPT (n=318) were reviewed from Jan 2010 to Sep 2020 in two tertiary medical centers in China. Patient clinicopathological and biological data were collected and analyzed.

Results: Of a total of 318 patients with PHPT, 105 (33.0%) patients had thyroid nodules and 26 (8.2%) patients were concomitant with thyroid cancer. A total of 38 thyroid nodules taken from 26 patients were pathologically assessed to be well-differentiated papillary thyroid carcinoma (PTC), with 81% being papillary thyroid microcarcinoma (PTMC). In 79% (30/38) of these cancers, thyroid nodules were considered suspicious following preoperative ultrasound. Multinomial logistic regression analysis revealed that female gender was associated with increased risk of thyroid nodules (OR=2.13, 95%CI: 1.13-3.99, p = 0.019), while lower log-transformed parathyroid hormone levels were an independent predictor of thyroid cancer in patients with PHPT (OR=0.50, 95%CI: 0.26-0.93, p = 0.028).

Conclusion: In conclusion, we observed a relatively high prevalence of thyroid cancer in our cohort of Chinese patients with PHPT. Evaluation of thyroid nodules by preoperative ultrasound may be advisable in patients with PHPT, particularly for females and patients with modestly elevated serum parathyroid hormone levels.
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http://dx.doi.org/10.1530/EC-21-0217DOI Listing
July 2021

Hierarchically Microstructure-Bioinspired Flexible Piezoresistive Bioelectronics.

ACS Nano 2021 Jun 15. Epub 2021 Jun 15.

Key Laboratory of Advanced Technologies of Materials (Ministry of Education), School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031, P. R. China.

The naturally microstructure-bioinspired piezoresistive sensor for human-machine interaction and human health monitoring represents an attractive opportunity for wearable bioelectronics. However, due to the trade-off between sensitivity and linear detection range, obtaining piezoresistive sensors with both a wide pressure monitoring range and a high sensitivity is still a great challenge. Herein, we design a hierarchically microstructure-bioinspired flexible piezoresistive sensor consisting of a hierarchical polyaniline/polyvinylidene fluoride nanofiber (HPPNF) film sandwiched between two interlocking electrodes with microdome structure. Ascribed to the substantially enlarged 3D deformation rates, these bioelectronics exhibit an ultrahigh sensitivity of 53 kPa, a pressure detection range from 58.4 to 960 Pa, a fast response time of 38 ms, and excellent cycle stability over 50 000 cycles. Furthermore, this conformally skin-adhered sensor successfully demonstrates the monitoring of human physiological signals and movement states, such as wrist pulse, throat activity, spinal posture, and gait recognition. Evidently, this hierarchically microstructure-bioinspired and amplified sensitivity piezoresistive sensor provides a promising strategy for the rapid development of next-generation wearable bioelectronics.
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http://dx.doi.org/10.1021/acsnano.1c01606DOI Listing
June 2021

Comparison of bioelectrical body and visceral fat indices with anthropometric measures and optimal cutoffs in relation to hypertension by age and gender among Chinese adults.

BMC Cardiovasc Disord 2021 Jun 11;21(1):291. Epub 2021 Jun 11.

School of Medicine, Nankai University, 94, Weijin Road, Tianjin, 300071, China.

Background: Few studies have compared bioelectrical body and visceral fat indices with anthropometric measures, or evaluated their optimal cutoffs in relation to hypertension among Asians. We compared the efficiencies of bioelectrical indices (percentage of body fat, PBF; visceral fat area, VFA) with anthropometric measures (body mass index, BMI; waist-hip ratio, WHR) for hypertension and re-evaluated the optimal cutoffs of each index by age and gender.

Methods: We conducted a cross-sectional survey among 8234 adults for health examination. PBF, VFA, BMI, WHR, and data on hypertension and behaviors were collected. Receiver operating characteristic (ROC) curve and areas under curves (AUCs) were used to analyze the efficiencies of the indices for hypertension, optimal cutoffs were estimated using the Youden index.

Results: A total of 8234 individuals aged 21-91 with median age 44 (interquartile range [IQR] 33-56) years were included and 40.56% were men. The overall prevalence of hypertension was 27.47%. The studied indices were all associated with hypertension in all age-specific groups both among men and women except for WHR in 21-29 years old men and PBF in in 21-29 years old women. Among males, there were no statistical differences in powers of four indices for hypertension in all age-specific groups, except for 40-49 years, in which WHR was better than VFA. Among females, no differences were found among the indices in 30-39 and 70-79 years groups, while WHR was the best in 21-29 years group, VFA was better than PBF in 30-39 and 50-59 years groups, BMI was better than PBF and WHR in 60-69 years group. The optimal cutoffs of PBF, VFA, BMI and WHR ranged from 23.9 to 28.7%, 86.4 to 106.9cm, 23.5 to 27.1 kg/m, 0.92 to 0.96 across the age categories in males, and 32.8 to 36.3%, 75.9 to 130.9cm, 21.9 to 26.4 kg/m, 0.84 to 0.95 across the age categories in females, respectively.

Conclusions: The obesity indices' efficiencies for hypertension varied by age and gender, and their cutoff values varied across the age categories and gender. Specific indices and cutoffs based on person's age and gender should be used to identify individuals with hypertension.
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http://dx.doi.org/10.1186/s12872-021-02100-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8196495PMC
June 2021

Effects of ZnMgO Electron Transport Layer on the Performance of InP-Based Inverted Quantum Dot Light-Emitting Diodes.

Nanomaterials (Basel) 2021 May 9;11(5). Epub 2021 May 9.

State Key Laboratory of Luminescent Materials and Devices, Institute of Polymer Optoelectronic Materials and Devices, South China University of Technology, Guangzhou 510640, China.

An environment-friendly inverted indium phosphide red quantum dot light-emitting diode (InP QLED) was fabricated using Mg-doped zinc oxide (ZnMgO) as the electron transport layer (ETL). The effects of ZnMgO ETL on the performance of InP QLED were investigated. X-ray diffraction (XRD) analysis indicated that ZnMgO film has an amorphous structure, which is similar to zinc oxide (ZnO) film. Comparison of morphology between ZnO film and ZnMgO film demonstrated that Mg-doped ZnO film remains a high-quality surface (root mean square roughness: 0.86 nm) as smooth as ZnO film. The optical band gap and ultraviolet photoelectron spectroscopy (UPS) analysis revealed that the conduction band of ZnO shifts to a more matched position with InP quantum dot after Mg-doping, resulting in the decrease in turn-on voltage from 2.51 to 2.32 V. In addition, the ratio of irradiation recombination of QLED increases from 7% to 25% using ZnMgO ETL, which can be attributed to reduction in trap state by introducing Mg ions into ZnO lattices. As a result, ZnMgO is a promising material to enhance the performance of inverted InP QLED. This work suggests that ZnMgO has the potential to improve the performance of QLED, which consists of the ITO/ETL/InP QDs/TCTA/MoO/Al, and Mg-doping strategy is an efficient route to directionally regulate ZnO conduction bands.
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http://dx.doi.org/10.3390/nano11051246DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8151885PMC
May 2021

Synergistic effect of carbon starvation and exogenous redox mediators on corrosion of X70 pipeline steel induced by Desulfovibrio singaporenus.

Sci Total Environ 2021 Sep 23;788:147573. Epub 2021 May 23.

Key Laboratory of Marine Environmental Corrosionand Bio-Fouling, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China; Open Studio for Marine Corrosion and Protection, Pilot National Laboratory for Marine Science and Technology (Qingdao), Qingdao 266237, China; Center for Ocean Mega-Science, Chinese Academy of Sciences, Qingdao 266071, China.

In microbiologically influenced corrosion (MIC) induced by sulfate-reducing bacteria (SRB), the electrons released from iron were transferred via extracellular electron transfer (EET) to the inner cells. Electron mediators and carbon starvation have also been found to promote steel corrosion. This study aimed to investigate the synergistic effects of electron mediators and carbon starvation on MIC and their effect on biofilm catalytic activity. The results demonstrated that the weight losses of X70 steel were 0.68 and 1.03 mg/cm in 100% and 10% carbon source (CS) SRB solution, respectively. The addition of riboflavin and cytochrome c increased the corrosion rate by 1.76 and 1.87 times, respectively, in the 100% CS SRB medium compared to the medium without exogenous redox mediators. For the 10% CS SRB medium, the corrosion rate increased by 1.40 and 1.89 times, respectively, when riboflavin and cytochrome c were added. The addition of riboflavin and cytochrome c also enhanced the biocatalytic activity of the SRB biofilm in both the 100% and 10% CS SRB media.
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http://dx.doi.org/10.1016/j.scitotenv.2021.147573DOI Listing
September 2021

High-Stability Flexible X-ray Detectors Based on Lead-Free Halide Perovskite CsTeI Films.

ACS Appl Mater Interfaces 2021 May 17;13(20):23928-23935. Epub 2021 May 17.

State Key Laboratory of Solidification Processing, Northwestern Polytechnical University, Xi'an 710072, China.

Normal flat panel X-ray detectors are confined in imaging of curved surfaces and three-dimensional objects. Except that, their rigid panels provide uncomfortable user experience in medical diagnosis. Here, we report a flexible X-ray detector fabricated by the combination of a lead-free CsTeI perovskite film and a polyimide (PI) substrate. High-quality CsTeI polycrystalline films are prepared by a low-temperature electrospraying method. The resistivity even remained at the level of 10 Ω·cm after 100 cycles of bending tests with a low bending radius of 10 mm. The resulting flexible CsTeI detectors exhibit better response stability than those based on rigid SnO:F glass (FTO), which is attributed to the superior crystallization of films and the growth stress relief of flexible substrates. Furthermore, an X-ray sensitivity of 76.27 μC·Gy·cm and a detection limit of 0.17 μGy·s are achieved. A series of distortion-free clear X-ray images are obtained for objects with different materials and densities. These findings provide insights into flexible X-ray detectors based on perovskite films and motivate research in wearable X-ray detectors for medical radiography and dose monitoring.
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http://dx.doi.org/10.1021/acsami.1c04252DOI Listing
May 2021

Tianlongkechuanling Inhibits Pulmonary Fibrosis Through Down-Regulation of Arginase-Ornithine Pathway.

Front Pharmacol 2021 22;12:661129. Epub 2021 Apr 22.

Traditional Chinese Medicine, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

Pulmonary Fibrosis (PF) is an interstitial lung disease characterized by excessive accumulation of extracellular matrix in the lungs, which disrupts the structure and gas exchange of the alveoli. There are only two approved therapies for PF, nintedanib (Nib) and pirfenidone. Therefore, the use of Chinese medicine for PF is attracting attention. Tianlongkechuanling (TL) is an effective Chinese formula that has been applied clinically to alleviate PF, which can enhance lung function and quality of life. The potential effects and specific mechanisms of TL have not been fully explored, yet. In the present study, proteomics was performed to explore the therapeutic protein targets of TL on Bleomycin (BLM)-induced Pulmonary Fibrosis. BLM-induced PF mice models were established. Hematoxylineosin staining and Masson staining were used to analyze histopathological changes and collagen deposition. To screen the differential proteins expression between the Control, BLM, BLM + TL and BLM + Nib (BLM + nintedanib) groups, quantitative proteomics was performed using tandem mass tag (TMT) labeling with nanoLC-MS/MS [nano liquid chromatographymass spectrometry]). Changes in the profiles of the expressed proteins were analyzed using the bioinformatics tools Gene Ontology (GO) and the Kyoto Encyclopedia of Genes and Genomes (KEGG). The protein-protein interactions (PPI) were established by STRING. Expressions of α-smooth muscle actin (α-SMA), (), () and enzymes in arginase-ornithine pathway were detected by Western blot or RT-PCR. TL treatments significantly ameliorated BLM-induced collagen deposition in lung tissues. Moreover, TL can inhibit the protein expressions of α-SMA and the mRNA expressions of and . Using TMT technology, we observed 253 differentially expressed proteins related to PPI networks and involved different KEGG pathways. Arginase-ornithine pathway is highly significant. The expression of Arg was significantly decreased after TL treatments. Administration of TL in BLM-induced mice resulted in decreasing pulmonary fibrosis. Our findings propose that the down regulation of arginase-ornithine pathway expression with the reduction of arginase biosynthesis is a central mechanism and potential treatment for pulmonary fibrosis with the prevention of TL.
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http://dx.doi.org/10.3389/fphar.2021.661129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8114272PMC
April 2021

A three-dimensional measurement based on CT for the posterior tilt with ideal inter-and intra-observer reliability in non-displaced femoral neck fractures.

Comput Methods Biomech Biomed Engin 2021 May 10:1-8. Epub 2021 May 10.

Department of Orthopaedic Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.

Posterior tilt is associated with prognosis of non-displaced femoral neck fractures (FNFs). Knowledge of their association is critical and informs surgeons whether to choose internal fixation or arthroplasty in treatment of non-displaced FNFs. This study aimed to design a novel three-dimensional (3D) posterior tilt measurement and evaluate the intra- and inter-observer variability compared to two-dimensional (2D) measurement proposed by Palm. We hypothesized that 3D measurement would be more accurate and realistic with higher reliability. To test the hypothesis, three observers measured the posterior tilt on the radiographs of 50 non-displaced FNFs, twice with both methods. Intra- and inter-observer reliability for each measurement method used were determined. The measured angle was divided into two categories, at the cut-off of 20° for clinical practice simulation. Intra- and inter-observer reliability were identified for clinical effectiveness. The results indicated that inter- and intra-observer reliability for 3D measurement and its classification was almost perfect with an intraclass coefficient of 0.995 (0.994) and a kappa value of 0.927(0.947), respectively. Conversely, a substantial inter- and intra-observer reliability for the 2D measurement was obtained with an interclass coefficient of 0.764 as well as an intraclass coefficient of 0.773. The clinical validity for 2D measurement showed slight inter-reliability and moderate intra-reliability with a kappa value of 0.192 and 0.587, respectively. Hence, the novel 3D measurement appears to be more reliable with a strong inter- and intra-observer reliability measurement. Further clinical studies are needed to carry out to validate this hypothesis.
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http://dx.doi.org/10.1080/10255842.2021.1925256DOI Listing
May 2021

Integrated Systems Pharmacology and Surface Plasmon Resonance Approaches to Reveal the Synergistic Effect of Multiple Components of Gu-Ben-Ke-Chuan Decoction on Chronic Bronchitis.

J Inflamm Res 2021 15;14:1455-1471. Epub 2021 Apr 15.

School of Life Sciences, Beijing University of Chinese Medicine, Beijing, 102488, People's Republic of China.

Introduction: Gu-Ben-Ke-Chuan (GBKC) decoction, a well-known prescription composed of seven herbs, has been widely used for treating chronic bronchitis (CB). However, the pharmacological constituents of GBKC and the underlying mechanisms by which these components act on CB remain unclear.

Methods: Ultra-high-pressure liquid chromatography coupled with linear ion trap-Orbitrap tandem mass spectrometry (UHPLC-LTQ-Orbitrap) was first employed to rapidly identify compounds from GBKC. Thereafter, network pharmacology and molecular docking analyses were performed to identify the potential active constituents, candidate targets, and major pathways. Finally, the affinities between the key compounds and targets were verified via surface plasmon resonance (SPR) analysis. In addition, the anti-inflammatory effect of GBKC was verified using an LPS-induced inflammatory cell model based on the predicted results.

Results: A total of 53 major compounds were identified in the GBKC decoction. After network pharmacology-based virtual screening, 141 major targets and 39 main compounds were identified to be effective in the treatment of CB. The major targets were highly enriched in the tumor necrosis factor (TNF) signaling pathway, suggesting that GBKC could attenuate the inflammatory response in patients with CB. Furthermore, molecular docking results indicated that 20 pairs of components and target proteins relevant to the TNF pathway exhibited notable interactions. Among them, eight compound-target pairs exhibited good affinity as per SPR analysis. In addition, the production of interleukin 6 and TNF-α in LPS-induced MH-S cells was suppressed after GBKC treatment.

Conclusion: This study successfully clarified the mechanism of action of GBKC against CB, which demonstrated that the integrated strategy described above is reliable for identifying the active compounds and mechanisms responsible for the pharmacological activities of GBKC decoction.
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http://dx.doi.org/10.2147/JIR.S303530DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8055291PMC
April 2021

Carboxymethyl chitosan‒promoted luminescence of lanthanide metallogel and its application in assay of multiple metal ions.

Carbohydr Polym 2021 Jul 26;263:117986. Epub 2021 Mar 26.

Key Laboratory of Materials Chemistry for Energy Conversion and Storage of the Ministry of Education, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan 430074, China. Electronic address:

In this work, the luminescence of lanthanide supramolecular metallogel formed by the self-assembly of 5,5',5″-(1,3,5-triazine-2,4,6-triyl)tris(azanediyl)triisophthalate (HL) and Tb was efficiently promoted by carboxymethyl chitosan (CMCS). The total quantum yield of the resultant metallogel (denoted as HL/Tb/CMCS gel) was 9 times higher than the gel without CMCS. The average lifetime of HL/Tb/CMCS gel increased from 0.51 ms to 1.20 ms. More importantly, the aqueous dispersion of HL/Tb/CMCS xerogels showed a stable and pH-dependent luminescence. Based on the selective affinity of CMCS to different metal ions as well as with the aid of principal component analysis, HL/Tb /CMCS can be used as a sensor array to distinguish 11 metal ions (P < 0.05). This work provides a new strategy for the design and development of bio-based functional luminescent lanthanide supramolecular metallogels.
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http://dx.doi.org/10.1016/j.carbpol.2021.117986DOI Listing
July 2021

Influence Factors and Prediction Model of Bond Strength of Tunnel Fireproof Coating under Freeze-Thaw Cycles.

Materials (Basel) 2021 Mar 22;14(6). Epub 2021 Mar 22.

College of Civil Engineering, Fuzhou University, Fuzhou 350108, China.

The freeze-thaw resistant performance of a tunnel fireproof coating (TFC) has an important impact on bonding property and durability. The influence of redispersible emulsion powder, polypropylene fiber and air-entraining agent on TFCs was studied. Transverse fundamental frequency and ultrasonic sound velocity were used to evaluate the damage degree of TFC, and the mechanism was revealed by SEM and pore structure. The results show that the most beneficial effect on bond strength of TFC is redispersible emulsion powder, followed by air-entraining agent, and then polypropylene fiber. After freeze-thaw cycles, the cumulative pore volume of micropores in the TFC increases obviously, while the porosity of macropores does not change significantly. A prediction model was proposed, which can calculate the bond strength from the damage degree of TFC under freeze-thaw cycles. The achievement can promote the application of TFC in cold regions.
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http://dx.doi.org/10.3390/ma14061544DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8004211PMC
March 2021

Enhanced Transmission from Visible to Terahertz in ZnTe Crystals with Scalable Subwavelength Structures.

ACS Appl Mater Interfaces 2021 Apr 31;13(14):16997-17005. Epub 2021 Mar 31.

The zinc blend nonlinear crystal of zinc telluride (ZnTe) is currently one of the most commonly used electro-optical material for terahertz (THz) probe and imaging. We report herein how to engineer the surface behavior of a ZnTe single crystal to design subwavelength structures (SWSs) for enhancing ultrabroadband transmission. Polystyrene (PS) nanoparticle monolayers with a maximum coverage of 85.2% were produced on the ZnTe crystal by an eccentric spin-coating technique combined with surface wettability engineering. Subsequently, the well-defined conical SWS arrays were fabricated on the ZnTe crystal by reactive ion etching over the PS monolayer template, with the size of the SWS arrays customized by optimizing the etching process. Finally, we demonstrated ultrabroadband antireflection on the surface structured ZnTe crystals in the visible-near-infrared, infrared, and terahertz regions with transmittance increase of 11.6%, 10.0%, and 24.8%, which are attributed to the decrease of surface Fresnel reflection by SWS. Notably, in 0.2-1.0 THz, the transmittance reached over 70%. Our work provides a new strategy to enhance the THz generation efficiency and detection sensitivity based on ZnTe crystals by surface engineering.
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http://dx.doi.org/10.1021/acsami.0c22772DOI Listing
April 2021

Association Between NAT2 Polymorphism and Lung Cancer Risk: A Systematic Review and Meta-Analysis.

Front Oncol 2021 11;11:567762. Epub 2021 Mar 11.

Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Anhui Medical University, Hefei, China.

Lung cancer is the leading cause of cancer-related death worldwide and has a high incidence rate. N-Acetyltransferase 2 (NAT2) is a polymorphic xenobiotic enzyme, which can catalyze N-acetylation and O-acetylation of various carcinogens such as aromatic, heterocyclic amines and hydrazines. At present, many studies have explored the effects of NAT2 polymorphism on lung cancer, but we found inconsistent results. We researched 18 published studies, involving 4,016 patients and 5,469 controls, to more accurately assess the effects of NAT2 polymorphism on lung cancer risk and to investigate whether smoking is associated. We used STATA software to analyze the extracted data and used STATA for subgroup analysis, sensitivity analysis, and to perform publication bias tests. To determine the correlation, we used the crude odds ratio (ORs) with 95% confidence interval (CIs). Our study was prospectively registered in PROSPERO (CRD42020159737). The odds ratio was 1.53 (95% CI: 1.211.95, I² = 45.2%, P=0.104) for the NAT2 slow + intermediate phenotype rapid phenotype. The results suggested that people with NAT2 non-rapid (slow + intermediate) phenotype have a significantly increased risk of lung cancer. In addition, NAT2 rapid phenotype was significantly associated with reduced risk of lung cancer, compared with slow phenotype or intermediate phenotype (slow phenotype . rapid phenotype: OR: 1.61, 95% CI: 1.07-2.42, I²= 50%, P= 0.075; intermediate phenotype . rapid phenotype: OR: 1.47, 95% CI: 1.15-1.88, I²= 40.3%, P= 0.137).
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http://dx.doi.org/10.3389/fonc.2021.567762DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7991837PMC
March 2021

After-effects of straw and straw-derived biochar application on crop growth, yield, and soil properties in wheat (Triticum aestivum L.) -maize (Zea mays L.) rotations: A four-year field experiment.

Sci Total Environ 2021 Aug 18;780:146560. Epub 2021 Mar 18.

Key Laboratory of Plant Nutrition and the Agri-environment in Northwest China, Ministry of Agriculture, Northwest A&F University, Yangling 712100, China.

Research on the after-effects of straw and straw-derived biochar applications on crop growth, yield, and retention of carbon (C) and nitrogen (N) in soil in wheat-maize rotation systems is limited, and has presented inconsistent conclusions. The purpose of this research was to compare the after-effects of straw and straw-derived biochar on wheat (Triticum aestivum L.) and maize (Zea mays L.) growth and yield, and on soil properties. A field experiment was conducted in four consecutive wheat-maize rotation cycles in the Loess Plateau of China under five treatments: CK (control without nitrogen and phosphate fertilizer, straw, or biochar); NP (conventional single application of nitrogen and phosphate chemical fertilizers); SNP (8 t ha wheat straw returned to the field plus fertilizer); B1NP (8 t ha straw-derived biochar plus fertilizer); B2NP (16 t ha straw-derived biochar plus fertilizer). The highest plant height and aboveground biomass for both wheat and maize always occurred with the B2NP treatment for the four study years. Grains per spike/ear and 1000-grain weight for both wheat and maize in B2NP and B1NP were significantly higher than observed for the other treatments. The four-year average wheat yields for NP, SNP, B1NP, and B2NP were 50.5%, 63.1%, 66.3%, and 81.7% greater than for CK, respectively, and the four-year average maize yields were 45.0%, 49.8%, 65.4%, and 72.1% greater than for CK, respectively. The application of straw-derived biochar significantly increased soil organic carbon, total nitrogen, microbial biomass carbon, and nitrogen in the soil surface layer compared with returning straw to the field. Both straw and straw-derived biochar reduced nitrate N leaching. Therefore, using straw-derived biochar to amend soil could be an appropriate practice for sustaining soil fertility and crop yield in wheat-maize rotation systems in the Loess Plateau of China.
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http://dx.doi.org/10.1016/j.scitotenv.2021.146560DOI Listing
August 2021

Solution-Grown Formamidinium Hybrid Perovskite (FAPbBr) Single Crystals for α-Particle and γ-Ray Detection at Room Temperature.

ACS Appl Mater Interfaces 2021 Apr 25;13(13):15383-15390. Epub 2021 Mar 25.

State Key Laboratory of Solidification Processing, MIIT Key Laboratory of Radiation Detection Materials and Devices, & School of Materials Science and Engineering, Northwestern Polytechnical University, Xi'an 710072, China.

Compared with the widely reported MAPbBr single crystals, formamidinium-based (FA-based) hybrid perovskites FAPbBr (FPB) with superior chemical and structure stability are expected to be more efficient and perform as more reliable radiation detectors at room temperature. Here, we employ an improved inverse temperature crystallization method to grow FPB bulk single crystals, where issues associated with the retrograde solubility behavior are resolved. A crystal growth phase diagram has been proposed, and accordingly, growth parameters are optimized to avoid the formation of NHPbBr secondary phase. The resulting FPB crystals exhibit a high resistivity of 2.8 × 10 Ω·cm and high electron and hole mobility-lifetime products (μτ) of 8.0 × 10 and 1.1 × 10 cm·V, respectively. Simultaneously, the electron and hole mobilities (μ) are evaluated to be 22.2 and 66.1 cm·V·s, respectively, based on the time-of-flight technique. Furthermore, a Au/FPB SC/Au detector is constructed that demonstrates a resolvable gamma peak from 59.5 keV Am γ-rays at room temperature for the first time. An energy resolution of 40.1% is obtained at 30 V by collecting the hole signals. These results demonstrate the great potential of FAPbBr as a hybrid material for γ-ray spectroscopy and imaging.
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http://dx.doi.org/10.1021/acsami.1c00174DOI Listing
April 2021

immobilization of Fe/FeC/FeO hollow hetero-nanoparticles onto nitrogen-doped carbon nanotubes towards high-efficiency electrocatalytic oxygen reduction.

Nanoscale 2021 Mar;13(10):5400-5409

Jiangsu Key Laboratory of New Power Batteries, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing, 210023, China.

The rational design of affordable, efficient and robust electrocatalysts towards the oxygen reduction reaction (ORR) is of vital importance for the future advancement of various renewable-energy technologies. Herein, we develop a feasible and delicate synthesis of Fe/Fe3C/Fe2O3 hollow heterostructured nanoparticles in situ immobilized on highly graphitic nitrogen-doped carbon nanotubes (referred to as Fe/Fe3C/[email protected] hereafter) via a simple hydrogel-bridged pyrolysis strategy. The simultaneous consideration of interfacial manipulation and nanocarbon hybridization endows the formed Fe/Fe3C/[email protected] with sufficiently well-dispersed and firmly immobilized active components, regulated electronic configuration, enhanced electrical conductivity, multidimensional mass transport channels, and remarkable structural stability. Consequently, benefiting from the compositional synergy and architectural superiority, the as-obtained Fe/Fe3C/[email protected] exhibit excellent ORR catalytic activity, impressive durability and superior selectivity in an alkaline electrolyte, outperforming the commercial Pt/C catalyst and a majority of the previously reported Fe-based catalysts. Furthermore, the rechargeable Zn-air battery using Fe/Fe3C/[email protected] + RuO2 as an air-cathode exhibits a higher power density, larger specific capacity and better cycling stability as compared with the state-of-the-art Pt/C + RuO2 counterpart. The explored hydrogel-bridged pyrolysis strategy enabling the concurrent heterointerface construction, nanostructure engineering and nanocarbon hybridization may inspire the future design of high-efficiency electrocatalysts for diverse renewable energy applications.
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http://dx.doi.org/10.1039/d1nr00078kDOI Listing
March 2021

Understanding the Percolation Effect in Triboelectric Nanogenerator with Conductive Intermediate Layer.

Research (Wash D C) 2021 4;2021:7189376. Epub 2021 Feb 4.

Key Laboratory of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China.

Introducing the conductive intermediate layer into a triboelectric nanogenerator (TENG) has been proved as an efficient way to enhance the surface charge density that is attributed to the enhancement of the dielectric permittivity. However, far too little attention has been paid to the companion percolation, another key element to affect the output. Here, the TENG with MXene-embedded polyvinylidene fluoride (PVDF) composite film is fabricated, and the dependence of the output capability on the MXene loading is investigated experimentally and theoretically. Specifically, the surface charge density mainly depends on the dielectric permittivity at lower MXene loadings, and in contrast, the percolation becomes the degrading factor with the further increase of the conductive loadings. At the balance between the dielectric and percolation properties, the surface charge density of the MXene-modified TENG obtained 350% enhancement compared to that with the pure PVDF. This work shed new light on understanding the dielectric and percolation effect in TENG, which renders a universal strategy for the high-performance triboelectronics.
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http://dx.doi.org/10.34133/2021/7189376DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7881766PMC
February 2021

Luminescence sensitization of terbium-loaded supramolecular gels by hydroxybenzoic acids and used for salicylates sensing.

Talanta 2021 Apr 30;225:122061. Epub 2020 Dec 30.

Key Laboratory of Materials Chemistry for Energy Conversion and Storage of the Ministry of Education, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan, 430074, China. Electronic address:

The luminescent terbium (Tb)-loaded supramolecular gels were facilely prepared through the self-assembly of Fmoc-diphenylalanine (FmocPhePhe) at room temperature. Hydroxybenzoic acid (HA, the isomers are denoted as 2-HA, 3-HA, and 4-HA depending upon the positions of hydroxyl groups) was used as a sensitizer to Tb. The luminescence sensitization of Tb in the gels was realized by the coordination with hydroxybenzoic acids. The spectra of luminescence, UV-vis, FT-IR, and H NMR verified that this sensitization was attributed to the energy transfer from hydroxybenzoic acids to Tb. The results of XRD, SEM, and phase transfer temperature further indicated that the initial molecule arrangement of the gels was significantly changed by 2-HA, resulting in more ordered and more compact morphology of the gels. 2-HA exhibited more effective sensitization to Tb in the gels than 3-HA and 4-HA. It was also found that 2-HA did not affect the self-assembly of FmocPhePhe. Due to the effective fluorescence sensitization by 2-HA, the as-prepared gels can be used for salicylic acid sensing with 6.8 μM of the detection limit. This strategy has been successfully used for the detection of salicylates in pharmaceuticals and cosmetics.
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http://dx.doi.org/10.1016/j.talanta.2020.122061DOI Listing
April 2021

Nanofibrous Grids Assembled Orthogonally from Direct-Written Piezoelectric Fibers as Self-Powered Tactile Sensors.

ACS Appl Mater Interfaces 2021 Mar 16;13(8):10623-10631. Epub 2021 Feb 16.

Key Laboratory of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031, P. R. China.

Tactile sensors are indispensable to wearable electronics, but still lack self-powering, high resolution, and flexibility. Herein, we present direct-written piezoelectric poly(vinylidene difluoride) fibers that are orthogonally assembled into nanofibrous grids (NFGs) as self-powered tactile sensors. Five nanofibrous strips (NFSs) are written on a polyurethane film via a uniform-field electrospinning (UFES) process, and two polyurethane films are orthogonally assembled into 5 × 5 NFGs with 25 pixels. Benefited from the mechanical flexibility and helical architecture of UFES fibers, stable piezoelectric outputs have been detected according to different locations or different pressures on an NFS, and a sensitivity of 7.1 mV/kPa is detected from the slope of voltage-pressure curves. In the orthogonally assembled NFGs, the pressure on a pixel of an NFS causes corresponding deformations of neighboring NFSs. The piezoelectric outputs vary with the distance from the pressing point, enabling us to position the pressing points and track the pressing trajectory in real time. Through judging piezoelectric outputs of all NFSs, precise locations of any pressed pixel with a resolution of 1 mm are presented vividly via luminous light-emitting diodes (LED), and the mapping profiles are displayed by pressing metal letters (S, W, J, T, and U) on multiple pixels. Furthermore, the coordinates of pressure either on an NFS or between NFSs with a resolution of 0.5 mm are reported digitally on a liquid crystal display (LCD). Thus, we developed novel self-powered tactile sensors with orthogonal NFGs to achieve real-time motion tracking, accurate spatial sensing, and location identification with high resolutions, which provide potential applications in electronic skin, robotics, and interface of artificial intelligence.
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http://dx.doi.org/10.1021/acsami.0c22318DOI Listing
March 2021

Spontaneous self-formation of molecular ferroelectric heterostructures.

Phys Chem Chem Phys 2021 Feb;23(5):3335-3340

State Key Laboratory of Solidification Processing & Key Laboratory of Radiation Detection Materials and Devices & School of Materials Science and Engineering, Northwestern Polytechnical University, Xi'an 710072, P. R. China.

A new phase of diisopropylammonium perchlorate (DIPAP) forms during freeze-drying or heat treatment, which generates the heterostructure with its original ferroelectric phase. There is no composition fluctuation in the DIPAP molecular ferroelectric heterostructures, but there is an interface between the two phases of DIPAP. The formation of the new phase resembles that of martensite in alloys. A large internal bias field that is almost 2.5 times of the coercive field was found in the molecular ferroelectric heterostructures, which is comparable to that of doped triglycine sulfate. The large internal bias field will promote the ability of the DIPAP heterostructure to adsorb PM2.5 under light. The spontaneous self-formation of molecular ferroelectric heterostructures may help improve the performance of molecular ferroelectric devices.
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http://dx.doi.org/10.1039/d0cp06060gDOI Listing
February 2021

Microstructure and interfacial metallurgical bonding of 1Cr17Ni2/carbon steel extreme high-speed laser cladding coating.

Adv Compos Hybrid Mater 2021 Jan 4:1-7. Epub 2021 Jan 4.

Zhenjiang Haili New Material Technology Co., Ltd, Zhenjiang, 212000 China.

The extreme high-speed laser cladding (EHLA) was employed to fabricate a 1Cr17Ni2 coating. The solidification behavior, phase transformation, and interfacial metallurgical bonding of the coating were systematically investigated. The results showed that the major phase transformation during solidification was liquid to γ-Fe. The large temperature gradient of melting pool and slow grow rate of γ-Fe grain contributed to the fine columnar prior austenite grain (PAG) in coating. The largest thermal conductivity of [0 0 1] crystal direction determined the preferential [0 0 1] orientation of PAG perpendicular to the liquid-solid interface. A thin γ-Fe layer (approximately 5 μm) was observed between coating and substrate. The Bain relationship between interfacial γ-Fe layer and substrate and the K-S relationship between interfacial γ-Fe layer and coating contributed to the reliable metallurgical bonding between coating and substrate. The shear test revealed the high shear strength (approximately 92% of that of substrate) and weaker plastic deformation ability of the interface. The interfacial γ-Fe layer effectively combined the coating and substrate via K-S and Bain crystallographic relationship.
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http://dx.doi.org/10.1007/s42114-020-00194-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7780920PMC
January 2021

[Study on Testing Methods of Pen-injector's Dosing Accuracy].

Authors:
Binbin Zhang

Zhongguo Yi Liao Qi Xie Za Zhi 2020 Dec;44(6):549-552

Shanghai Testing and Inspection Institute for Medical Devices, Shanghai, 201318.

Objective: An accuracy test method is proposed to reduce the amount of reagents used in the test and reduce the cost of spot checks and self-tests.

Methods: According to the requirements of dose accuracy test in standard atmospheric conditions in ISO 11608-1:2014, dose accuracy test is carried out for the same batch of reusable pen injector samples by using the test method proposed in this paper and the test method in relevant foreign research, and the data measured by the two methods are processed.

Results: After experimental testing and analysis, the data measured by the two methods did not exceed the dose accuracy limit specified in the ISO standard. There was no significant difference between the two methods when the dose of 60 U and 30 U were tested, but there was significant difference when the dose of 1 U was tested.

Conclusions: Both methods can be used to evaluate dose accuracy, however, the method proposed in this paper can reduce the usage of drugs by 2/3, so it can reduce cost of supervised test.
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http://dx.doi.org/10.3969/j.issn.1671-7104.2020.06.017DOI Listing
December 2020

Microbiota Imbalance Contributes to COPD Deterioration by Enhancing IL-17a Production via miR-122 and miR-30a.

Mol Ther Nucleic Acids 2020 Dec 23;22:520-529. Epub 2020 Sep 23.

Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China.

The changes of microbiota in lungs could change interleukin-17a (IL-17a) expression by altering microRNAs (miRNAs) profile, thus contributing to the pathogenesis of chronic obstructive pulmonary disease (COPD). In this study, we aimed to study molecular mechanisms' underlying effect of microbiota imbalance on COPD deterioration. Real-time polymerase chain reaction (PCR) and enzyme-linked immunosorbent assay (ELISA) were performed to analyze expression of miRNAs and IL-17a mRNA. ELISA was used to evaluate abundance of IL-17a in plasma, peripheral blood monocyte, and sputum of COPD mice and patients. Luciferase assay was performed to explore underlying molecular mechanisms. The expression of miR-122, miR-30a, and miR-99b were remarkably decreased in COPD mice, while the expression of IL-17a was notably increased in plasma, peripheral blood monocytes, and lung tissues of COPD mice. The levels of Lactobacillus/Moraxella and IL-17a expression were significantly enhanced in sputum of exacerbated COPD patients, along with notably decreased expression of miR-122 and miR-30a. Luciferase assay confirmed that miR-122 and miR-30a played an inhibitory role in IL-17a expression. We identified miR-122 and miR-30a as differentially expressed miRNAs in sputum and plasma of COPD patients in exacerbation-month12 group. Furthermore, downregulated miR-122 and miR-30a expression associated with microbiota imbalance may contribute to COPD deterioration by enhancing IL-17a production.
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http://dx.doi.org/10.1016/j.omtn.2020.09.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7558803PMC
December 2020

Anisotropic dielectric behavior of layered perovskite-like CsBiI crystals in the terahertz region.

Phys Chem Chem Phys 2020 Nov 23;22(42):24555-24560. Epub 2020 Oct 23.

Key Laboratory of Radiation Detection Materials and Devices, MIIT, School of Materials Science and Engineering & State Key Laboratory of Solidification Processing, Northwestern Polytechnical University, Xi'an, Shaanxi 710072, China.

The ternary metal halide perovskites have gradually attracted attention for application in the optoelectronic field, owing to their tunable crystal structure and appropriate bandgap. Lead free CsBiI perovskite, with a 0D layered structure containing molecular [BiI] dimers, exhibits prominent optical and electrical anisotropies. Here, the anisotropic properties of the CsBiI crystals were evaluated using terahertz time-domain spectroscopy (THz-TDS); meanwhile, the effect of phonon vibration on the THz transmission was confirmed using density functional perturbation theory (DFPT). Accordingly, the refractive index and extinction coefficient are estimated using THz-TDS, thanks to the high transmission in the range of 0.2-0.9 THz. The anisotropic refractive index was observed for the CsBiI crystals, and was found to be 3.2-3.7 for the (100) plane (CBI) in contrast to 2.8-3.2 for the (001) plane (CBI). Furthermore, the Lorentz model was employed to extract the dielectric constant of CsBiI, in which anisotropy is obviously indicated by the static dielectric constant and the high-frequency dielectric constant. These anisotropic behaviors are determined by the dipole moment, which is attributed to the anisotropic packing density of [BiI] dimers. This study is significant and provides a deeper insight into the anisotropic photoelectric properties of CsBiI, thus contributing to the development of metal halide perovskites in the field of optoelectronics.
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http://dx.doi.org/10.1039/d0cp04485gDOI Listing
November 2020

MnCO on Graphene Porous Framework via Diffusion-Driven Layer-by-Layer Assembly for High-Performance Pseudocapacitor.

ACS Appl Mater Interfaces 2020 Oct 8;12(42):47695-47703. Epub 2020 Oct 8.

School of Physical Science and Technology, ShanghaiTech University, Shanghai 201210, China.

Diffusion-driven layer-by-layer (dd-LbL) assembly is a simple yet versatile process that can be used to construct graphene oxide (GO) into a three-dimensional (3D) porous framework with good mechanical stability. In particular, the oxygen functional groups on the GO surface are well retained, providing nucleation sites for further chemical reactions to be performed upon. Therefore, such a scaffold should serve as a promising starting material for creating a wide range of 3D graphene-based composites while maintaining a high accessible surface area. Herein, we demonstrate the use of the porous GO macrostructure derived from dd-LbL assembly for the preparation of graphene-MnCO hybrid structures. MnCO is a newly reported pseudocapacitive material for supercapacitors; however, its electrochemical performance is hampered by its low electrical conductivity and poor chemical stability. Through reaction between KMnO and GO during a hydrothermal process, the surface of the porous scaffold was rendered with uniform MnCO nanoparticles. With the reduced graphene oxide (rGO) sheets serving as the conductive backbone, the resultant MnCO nanoparticles exhibited a capacitance of 698 F g at a charge/discharge current of 0.5 mA (320 F g for the combined rGO and MnCO composite). Furthermore, the electrode maintained 77% of its initial capacity even after 5000 cycles of charge/discharge tests at 20 mA.
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http://dx.doi.org/10.1021/acsami.0c15511DOI Listing
October 2020

Exosomal Circ-MEMO1 Promotes the Progression and Aerobic Glycolysis of Non-small Cell Lung Cancer Through Targeting MiR-101-3p/KRAS Axis.

Front Genet 2020 28;11:962. Epub 2020 Aug 28.

Department of Endocrinology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Circular RNA mediator of cell motility 1 (circ-MEMO1) was identified as an oncogene in non-small cell lung cancer (NSCLC). Nevertheless, the working mechanism behind circ-MEMO1-mediated progression of NSCLC is barely known. Quantitative real-time polymerase chain reaction (qRT-PCR) was applied to detect the expression of circ-MEMO1, microRNA-101-3p (miR-101-3p), and KRAS proto-oncogene, GTPase (KRAS). Cell proliferation and aerobic glycolysis were detected by 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and glycolysis detection kits. Flow cytometry was used to evaluate cell cycle progression and apoptosis of NSCLC cells. Western blot assay was used to measure the protein expression of hexokinase 2 (HK2), lactate dehydrogenase A (LDHA), KRAS, CD9, CD81, tumor susceptibility 101 (TSG101), and Golgi matrix protein 130 kDa (GM130). The target relationship between miR-101-3p and circ-MEMO1 or KRAS was predicted by StarBase software and confirmed by dual-luciferase reporter assay, RNA immunoprecipitation (RIP) assay, and RNA-pull down assay. tumor growth assay was conducted to assess the effect of circ-MEMO1 . Exosomes were isolated using the ExoQuick precipitation kit. Circ-MEMO1 was up-regulated in NSCLC, and high expression of circ-MEMO1 predicted poor prognosis in NSCLC patients. Circ-MEMO1 accelerated the proliferation, cell cycle progression, and glycolytic metabolism and inhibited the apoptosis of NSCLC cells. Circ-MEMO1 negatively regulated the expression of miR-101-3p through direct interaction, and si-circ-MEMO1-induced biological effects were attenuated by the introduction of anti-miR-101-3p. MiR-101-3p directly interacted with the 3' untranslated region (3' UTR) of KRAS messenger RNA (mRNA), and KRAS level was regulated by circ-MEMO1/miR-101-3p axis. Circ-MEMO1 silencing suppressed the NSCLC tumor growth . ROC curve analysis revealed that high expression of serum exosomal circ-MEMO1 (exo-circ-MEMO1) might be a valuable diagnostic marker for NSCLC. Circ-MEMO1 facilitated the progression and glycolysis of NSCLC through regulating miR-101-3p/KRAS axis.
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http://dx.doi.org/10.3389/fgene.2020.00962DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7483554PMC
August 2020

Fabrication of a Novel AgBr/[email protected] Composite with Excellent Visible Light Photocatalytic Property for Antibacterial Use.

Nanomaterials (Basel) 2020 Aug 6;10(8). Epub 2020 Aug 6.

CAS Key Laboratory of Marine Environmental Corrosion and Bio-fouling, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China.

A novel AgBr/[email protected] composite photocatalyst with different heterojunction structures was successfully constructed by compounding InVO with AgMoO and AgBr. According to the degradation, antibacterial and free radical trapping data, the photocatalytic antibacterial and antifouling activities of AgBr/[email protected] composite were evaluated, and the corresponding photocatalytic reaction mechanism was proposed. Adding AgBr/[email protected] composite, the degradation rate of ciprofloxacin (CIP) achieved 95.5% within 120 min. At the same time, the antibacterial rates of (), () and () achieved 99.99%. The AgBr/[email protected] composite photocatalyst showed promising usage in photocatalytic antibacterial and purification areas.
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http://dx.doi.org/10.3390/nano10081541DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7466578PMC
August 2020
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