Publications by authors named "Bin Zheng"

773 Publications

The role of eco-tourism in ecological conservation in giant panda nature reserve.

J Environ Manage 2021 Jun 17;295:113077. Epub 2021 Jun 17.

College of Economics & Management, South China Agricultural University, Guangzhou, Guangdong, 510642, China. Electronic address:

Eco-tourism is rapidly developing in giant panda nature reserves in China, and is considered a popular tool for biodiversity conservation and the welfare of local communities. However, there is lack of empirical evidence on whether eco-tourism promotes the conservation behavior of local communities members, who live around nature reserves. To this end, this study constructed a framework to measure households' forest conservation activities, and conducted a questionnaire survey in 12 giant panda nature reserves in Sichuan Province, China. A total of 686 valid samples were obtained. A logit model was used to confirm whether income from community-based ecotourism (CBET) could enhance households' conservation behavior. The results show that households prefer three types of conservation practices, and CBET could significantly improve the income of households engaged in it. Income from CBET has motivated local households to participate in conservation activities; however, but the effects are different. In all three conservation activities, income from CBET has shown significant effects on promoting forest maintenance and protection activities, but not on reforestation ones. The results of this research could help us better understand the relationship between CBET and local households' conservation behavior. It also provides information for policymakers seeking for the best way to balance conservation and development.
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http://dx.doi.org/10.1016/j.jenvman.2021.113077DOI Listing
June 2021

(SM) Injection Ameliorates Iron Overload-Associated Cardiac Dysfunction by Regulating the Expression of DMT1, TfR1, and FP1 in Rats.

Evid Based Complement Alternat Med 2021 26;2021:6864723. Epub 2021 May 26.

School of Pharmacy, Hebei University of Chinese Medicine, Shijiazhuang 050200, Hebei, China.

Previous studies have found that (SM) injection have a protective effect on the iron overloaded (IO) heart. However, the mechanisms are not completely known. In the present study, we investigated the underlying mechanisms based on the iron transport-related proteins. The rats were randomly divided into five groups: control, IO group, low-dose SM group, high-dose SM group, and deferoxamine control group. Iron dextran was injected to establish the IO model. After 14 days of treatment, cardiac histological changes were observed by hematoxylin and eosin (H&E) staining. Iron uptake-related proteins divalent metal transporter-1 (DMT-1), transferrin receptor-1 (TfR-1), and iron export-related proteins ferroportin1 (FP1) in the heart were detected by Western blotting. The results showed that SM injection decreased cardiac iron deposition, ameliorated cardiac function, and inhibited cardiac oxidation. Most important of all, SM injection downregulated the expression of DMT-1 and TfR-1 and upregulated FP1 protein levels compared with the IO group. Our results indicated that reducing cardiac iron uptake and increasing iron excretion may be one of the important mechanisms of SM injection reducing cardiac iron deposition and improving cardiac function under the conditions of IO.
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http://dx.doi.org/10.1155/2021/6864723DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8175163PMC
May 2021

Metal-free carbon monoxide-releasing micelles undergo tandem photochemical reactions for cutaneous wound healing.

Chem Sci 2020 Apr 14;11(17):4499-4507. Epub 2020 Apr 14.

CAS Key Laboratory of Soft Matter Chemistry, Hefei National Laboratory for Physical Science at the Microscale, Department of Polymer Science and Engineering, University of Science and Technology of China Hefei 230026 Anhui China

Carbon monoxide (CO) has shown broad biomedical applications. The site-specific delivery and controlled release of CO is of crucial importance to achieve maximum therapeutic benefits. The development of carbon monoxide (CO)-releasing polymers (CORPs) can increase the stability, optimize pharmacokinetic behavior, and reduce the side effects of small molecule precursors. However, almost all established CORPs were synthesized through a post functional approach, although the direct polymerization strategy is more powerful in controlling the chain compositions and architectures. Herein, a direct polymerization strategy is proposed toward metal-free CO-releasing polymers (CORPs) based on photoresponsive 3-hydroxyflavone (3-HF) derivatives. Such CO-releasing amphiphiles self-assemble into micelles, having excellent water-dispersity. Intriguingly, photo-triggered tandem photochemical reactions confer successive fluorescence transitions from blue-to-red-to-colorless, enabling self-reporting CO release and as a result of the incorporation of 3-HF derivatives. More importantly, the localized CO delivery of CORPs by taking advantage of the spatiotemporal control of light stimulus outperformed conventional metal carbonyls such as CORMs in terms of anti-inflammation and cutaneous wound healing. This work opens a novel avenue toward metal-free CORPs for potential biomedical applications.
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http://dx.doi.org/10.1039/d0sc00135jDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8159483PMC
April 2020

Patented technologies for schistosomiasis control and prevention filed by Chinese applicants.

Infect Dis Poverty 2021 Jun 12;10(1):84. Epub 2021 Jun 12.

National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Chinese Center for Tropical Diseases Research, Key Laboratory of Parasite and Vector Biology, National Health Commission, WHO Centre for Tropical Diseases, National Center for International Research On Tropical Diseases, Ministry of Science and Technology, Shanghai, 200025, China.

Background: Many valuable and productive patented technologies have been developed to control schistosomiasis in China in the past 70 years. We conducted a research to analyse patented technologies for schistosomiasis control and prevention filed by Chinese applicants for determining the future patent layout.

Methods: The patent databases of China National Intellectual Property Administration and Baiten were comprehensively searched, and patented technologies for schistosomiasis control and prevention, published between January 1950 and December 2020 filed by Chinese applicants were sorted on 30 December 2020. The patent types, technical fields, and patent development trends were analysed using patent indexing.

Results: There are 184 valid schistosomiasis control technology patents, among them 128 invention patents. The patents related to schistosomiasis control and prevention technology have gone through the germination, growth, and maturity stages. These phases correspond with three phases in schistosomiasis control in China. The main technical aspects were fundamental research (n = 37), detection (n = 13), chemotherapy (n = 61), and armamentarium/devices (n = 73), of which the number of patents for detection for diagnosis was smaller. The top three specialised technical fields for patents subgroups, focusing on antiparasitic agents, DNA or RNA, vectors and medicines, of which schistosomicides are the major dominant subgroup.

Conclusions: We recommend that technologies to be patented for schistosomiasis control and prevention be focused on detection, preliminary studies for molecular detection methods should be significantly enhanced, and patent layout must be performed, which will, in turn, promote accuracy of early diagnosis, not only in humans but also in livestock. It is necessary to develop more anti-schistosomal drugs safely and effectively, exceptionally eco-friendly molluscicides and herbal extracts anti-schistosomes, improve treatment, develop vaccines for use in humans.
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http://dx.doi.org/10.1186/s40249-021-00869-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8199835PMC
June 2021

CMA-Net: Cross-modal Cross-Attention Network for Acute Ischemic Stroke Lesion Segmentation based on CT Perfusion Scans.

IEEE Trans Biomed Eng 2021 Jun 8;PP. Epub 2021 Jun 8.

Objective: Based on the hypothesis that adding a cross-modal and cross-attention (CMA) mechanism into a deep learning network improves accuracy and efficacy of medical image segmentation, we propose to test a novel network to segment acute ischemic stroke (AIS) lesions from four CT perfusion (CTP) maps.

Methods: The proposed network uses a CMA module directly to establish a spatial-wise relationship by using the multigroup non-local attention operation between two modal features and performs dynamic group-wise recalibration through group attention block. This CMA-Net has a multipath encoder-decoder architecture, in which each modality is processed in different streams on the encoding path, and the pair related parameter modalities are used to bridge attention across multimodal information through the CMA module. A public dataset involving 94 training and 62 test cases are used to build and evaluate the CMA-Net. AIS segmentation results on the test cases are analyzed and compared with other state-of-the-art models reported in the literature.

Results: By calculating several average evaluation scores, CMA-network improves Recall, F1, and F2 scores by 4.0%, 1.4%, and 3.0%, respectively. In the ablation experiment, the F1 score of CMA-Net is at least 7.8% higher than that of single-input single-modal self-attention networks.

Conclusion: This study demonstrates advantages of applying CMA-network to segment AIS lesions, which yields promising segmentation accuracy, and achieves semantic decoupling by processing different parameter modalities separately.

Significance: Proving the potential of cross-modal interactions in attention to assist identifying new imaging biomarkers for more accurately predicting AIS prognosis in future studies.
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http://dx.doi.org/10.1109/TBME.2021.3087612DOI Listing
June 2021

Exsolution of Iron Oxide on LaFeO Perovskite: A Robust Heterostructured Support for Constructing Self-Adjustable Pt-Based Room-Temperature CO Oxidation Catalysts.

ACS Appl Mater Interfaces 2021 Jun 6;13(23):27029-27040. Epub 2021 Jun 6.

State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, Jilin University, 2699 Qianjin Road, Changchun 130012, Jilin, China.

Constructing highly active and stable surface sites for O activation is essential to lower the barrier of Pt-based catalysts for CO oxidation. Although a few active Pt-metal oxide interfaces have been reported, questions about the stability of these sites under the long-term storage and operation remain unresolved. Here, based on developing a robust FeO/LaFeO heterostructure as a support, we constructed stable Pt-support interfaces to achieve highly active CO oxidation at room temperature. Even after it is kept in the air for more than 6 months, the catalyst (without pretreatment) still maintains the high activity like a fresh one, which is superior to metal hydroxide-Pt interfaces, and meets the requirements of long-term storage for emergency use. In situ characterizations and systematic reaction results showed that CO oxidation occurs through an alternative mechanism, which is triggered by intrinsic reactants and self-adjusted to a more active interface in the reaction process. Theoretical calculations and Fe Mössbauer spectra revealed that abundant cation vacancies significantly increase the activity of surface oxygen species and should be responsible for this unique process. This work demonstrates an alternative concept to fabricate robust and highly active Pt-based catalysts for catalytic oxidation.
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http://dx.doi.org/10.1021/acsami.1c04836DOI Listing
June 2021

Factors Associated With Individual Emergency Preparedness Behaviors: A Cross-Sectional Survey Among the Public in Three Chinese Provinces.

Front Public Health 2021 21;9:644421. Epub 2021 May 21.

School of Health Management, Harbin Medical University, Harbin, China.

This study aimed to identify factors associated with individual emergency preparedness behaviors which play an important role in effective emergency response. Data were drawn from a cross-sectional survey conducted in China's Heilongjiang, Guangdong and Sichuan provinces in 2017. Questionnaires were administered through face-to-face interviews, and 2,506 were valid for data analyses. A structural equation model was established to test the direct and indirect effects of the relevant factors on individual emergency preparedness behaviors. Low levels of emergency preparedness were found: 28% of respondents reported being fully/partly prepared. The attitudes of the respondents toward emergency preparedness had the strongest association with emergency preparedness behaviors, with a total effect of 0.483. This was followed by self-efficacy (0.305) and training/exercise (0.295). Risk perception had the weakest effect (0.045) on emergency preparedness behaviors. Improving attitudes of the public as well as their ability to prepare for emergency events is important for effective emergency management.
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http://dx.doi.org/10.3389/fpubh.2021.644421DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8175617PMC
June 2021

Engineering micromechanics of soft porous crystals for negative gas adsorption.

Chem Sci 2020 Aug 24;11(35):9468-9479. Epub 2020 Aug 24.

Faculty of Chemistry and Food Chemistry, TU Dresden Bergstrasse 66 01069 Dresden Germany

Framework materials at the molecular level, such as metal-organic frameworks (MOF), were recently found to exhibit exotic and counterintuitive micromechanical properties. Stimulated by host-guest interactions, these so-called soft porous crystals can display counterintuitive adsorption phenomena such as negative gas adsorption (NGA). NGA materials are bistable frameworks where the occurrence of a metastable overloaded state leads to pressure amplification upon a sudden framework contraction. How can we control activation barriers and energetics functionalization of the molecular building blocks that dictate the frameworks' mechanical response? In this work we tune the elastic and inelastic properties of building blocks at the molecular level and analyze the mechanical response of the resulting frameworks. From a set of 11 frameworks, we demonstrate that widening of the backbone increases stiffness, while elongation of the building blocks results in a decrease in critical yield stress of buckling. We further functionalize the backbone by incorporation of sp hybridized carbon atoms to soften the molecular building blocks, or stiffen them with sp and sp carbons. Computational modeling shows how these modifications of the building blocks tune the activation barriers within the energy landscape of the guest-free bistable frameworks. Only frameworks with free energy barriers in the range of 800 to 1100 kJ mol per unit cell, and moderate yield stress of 0.6 to 1.2 nN for single ligand buckling, exhibit adsorption-induced contraction and negative gas adsorption. Advanced experimental methodologies give detailed insights into the structural transitions and the adsorption behavior. The new framework DUT-160 shows the highest magnitude of NGA ever observed for nitrogen adsorption at 77 K. Our computational and experimental analysis of the energetics and mechanical response functions of porous frameworks is an important step towards tuning activation barriers in dynamic framework materials and provides critical design principles for molecular building blocks leading to pressure amplifying materials.
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http://dx.doi.org/10.1039/d0sc03727cDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8162094PMC
August 2020

Cost-Effectiveness Analysis of Dacomitinib versus Gefitinib in the First-Line Treatment of EGFR-Positive Advanced or Metastatic Non-Small Cell Lung Cancer.

Cancer Manag Res 2021 28;13:4263-4270. Epub 2021 May 28.

Department of Pharmacy, Fujian Medical University Union Hospital, Fujian Medical University, Fuzhou, Fujian Province, People's Republic of China.

Background: The objective of the study was to evaluate the economics of dacomitinib and gefitinib in the first-line treatments for EGFR-positive advanced or metastatic non-small cell lung cancer (NSCLC) from a US payer perspective.

Methods: We developed the partition survival model to compare the lifetime cost and health outcomes of dacomitinib versus gefitinib. Transition probabilities were collected from the ARCHER 1050 trial. The model only considered the direct medical costs. Utility values were taken from published research.

Results: Compared to gefitinib, dacomitinib increased 0.706 QALY and the cost increased $232,359.32. The incremental cost-effectiveness ratio (ICER) was $329,120.85 per QALY in the base case. One-way sensitivity analysis showed that the cost of drugs and the utility had more influence on the results than other parameters. Probability sensitivity analysis reflected that the parameters had little effect on the results.

Conclusion: Dacomitinib could improve the health benefits and increase the overall costs. In this simulation, dacomitinib is not likely to be economical for first-line therapy of EGFR-mutated NSCLC.
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http://dx.doi.org/10.2147/CMAR.S293983DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8168962PMC
May 2021

Homogeneous material based acoustic concentrators and rotators with linear coordinate transformation.

Sci Rep 2021 Jun 1;11(1):11531. Epub 2021 Jun 1.

College of Information Science and Electronic Engineering Zhejiang University, Hangzhou, 310058, People's Republic of China.

With the ability to focus and rotate the acoustic field in a given region while keeping the outside region unchanged, the acoustic concentrator and rotator has been developed for the versatile manipulations of acoustic wave. In this letter, we report the design of acoustic concentrator and rotator facilitated by linear coordinate transformation. Compared with the previous ones that have inhomogeneous parameter distributions, the designed devices are composed of several parts with homogeneous parameters, which can be achieved with the help of few homogeneous layered structures. Simulations are also performed to verify the functions of the designed device. The proposed acoustic concentrators and rotators would be useful in numerous applications such as acoustic sensing and communication.
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http://dx.doi.org/10.1038/s41598-021-91146-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8169701PMC
June 2021

Hypoxic tumor-derived exosomal miR-31-5p promotes lung adenocarcinoma metastasis by negatively regulating SATB2-reversed EMT and activating MEK/ERK signaling.

J Exp Clin Cancer Res 2021 Jun 1;40(1):179. Epub 2021 Jun 1.

Department of Thoracic Surgery, Fujian Medical University Union Hospital, #29 Xinquan Road, 350001, Fuzhou, Fujian, China.

Background: Exosomes have emerged as critical mediators of intercellular communication. Hypoxia is widely recognized as a key regulator of tumor aggressiveness, and significantly affects exosome release by tumor cells. However, the effects of exosomes derived from hypoxic lung adenocarcinoma (LUAD) cells are poorly understood.

Methods: Samples of miRNA isolated from hypoxic LUAD cell-derived exosomes (HExo) and normoxic LUAD cell-derived exosomes (NExo) were sequenced to identify miRNAs that might mediate tumor progression. Exosomal miRNA was co-cultured with LUAD cells to assess its biological effects on cell migration and metastasis both in vitro and in vivo. The cellular target of exosomal miRNA was confirmed by dual-luciferase assays. Western blot studies showed that exosomal miRNA regulated the related pathway. The availability of circulating exosomal miRNA derived from plasma was also evaluated.

Results: We found that HExo could significantly enhance the migration and invasion of normoxic LUAD cells. MiRNA sequencing results suggested that miR-31-5p was largely internalized within HExo and could be taken up by normoxic LUAD cells. Exosomal miR-31-5p was found to directly target Special AT-Rich Sequence-Binding Protein 2 (SATB2)-revered epithelial mesenchymal transition and significantly increase activation of MEK/ERK signaling, thereby contributing to tumor progression both in vitro and in vivo. Furthermore, higher levels of circulating exosomal miR-31-5p were detected in LUAD patients, especially in patients with metastatic disease.

Conclusions: Our findings demonstrate that exosomal miR-31-5p exerts a crucial role in LUAD progression, and could serve as a diagnostic biomarker for LUAD.
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http://dx.doi.org/10.1186/s13046-021-01979-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8167983PMC
June 2021

Does surgery benefit patients with oligometastatic or metastatic prostate cancer? - A retrospective cohort study and meta-analysis.

Prostate 2021 May 31. Epub 2021 May 31.

The School of Medicine, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.

Background: To evaluate long-term oncological outcomes of radical prostatectomy (RP) plus androgen deprivation therapy (ADT) in oligometastatic prostate cancer (PCa) patients.

Methods: Our study included oligometastatic PCa patients hospitalized between January 1, 2010 and December 31, 2015, who received ADT with or without RP. We evaluated survival by employing Kaplan-Meier methods, with log-rank tests and univariate and multivariate Cox regression analyses. A meta-analysis of previously published studies was additionally performed.

Results: The median follow-up times of both groups were 68.4 months (interquartile range = 56.5-85.0). In this cohort study, significant statistical difference in preoperative total prostate-specific antigen (tPSA; p = .121), clinical T stage (p = .115), and N stage (p = .394) were not found between the two groups. Meanwhile, the difference in overall survival (OS) between the two groups did not reach statistical significance (p = .649). A significant difference was not observed in castration-resistant prostate cancer (CRPC)-free survival between two groups as well (p = .183). Numbers of metastases might be an independent prognosis factor (p = .05) for OS, and postoperative tPSA is a risk predictor for CRPC-free survival (p = .032). A meta-analysis of four relevant studies demonstrated significant statistical difference in clinical improvement with RP plus ADT over ADT alone in OS survival (p < .001; hazard ratio [HR] = 0.51; 95% confidence interval [CI] = 0.38-0.69) instead of CRPC-free survival (p = .42; HR = 0.86; 95% CI = 0.59-1.24).

Conclusion: The addition of RP to ADT for the treatment of oligometastatic PCa was associated with an improved OS instead of CRPC-free survival.
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http://dx.doi.org/10.1002/pros.24170DOI Listing
May 2021

A mutational signature for colorectal cancer prognosis prediction: Associated with immune cell infiltration.

Clin Transl Med 2021 May;11(5):e414

Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, Department of Colorectal Surgery, Guangdong Institute of Gastroenterology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.

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http://dx.doi.org/10.1002/ctm2.414DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8101534PMC
May 2021

cRGD peptide-conjugated polyethylenimine-based lipid nanoparticle for intracellular delivery of siRNA in hepatocarcinoma therapy.

Drug Deliv 2021 Dec;28(1):995-1006

School of Pharmacy, Shanxi Medical University, Taiyuan, China.

The effective delivery system plays an important role in the application of siRNA in the antitumor study. However, until now, researches on the delivery systems targeting hepatocarcinoma cells are still being explored. Here we designed and prepared a novel siRNA delivery system, cRGD-PSH-NP, which was based on a modified polyethyleneimine (PSH) and DSPE-PEG-cRGD. cRGD-PSH-NP loaded with survivin siRNA (cRGD-PSH-NP/S) was composed of egg phosphatidylcholine, cationic PSH, PEGylated lipids, survivin siRNA, and cRGD peptide as a targeting ligand. The formulations of cRGD-PSH-NP/S were optimized and characterized. investigations showed excellent gene silencing and antitumor activity compared with the unmodified nanoparticles in HepG2 cells. antitumor efficacy of cRGD-PSH-NP/S exhibited potent tumor inhibition (74.71%) in HepG2-bearing nude mice without inducing toxicity. These data suggested further research of cRGD-PSH-NP/S in hepatocarcinoma therapy.
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http://dx.doi.org/10.1080/10717544.2021.1928794DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8168781PMC
December 2021

NUPR1 is a novel potential biomarker and confers resistance to sorafenib in clear cell renal cell carcinoma by increasing stemness and targeting the PTEN/AKT/mTOR pathway.

Aging (Albany NY) 2021 05 24;13(10):14015-14038. Epub 2021 May 24.

Department of Urology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.

Background: Sorafenib can improve the survival of metastatic clear cell renal cell carcinoma (ccRCC) patients. However, its benefits are modest, as patients eventually become resistant, and the mechanisms remain elusive. NUPR1, a stress-induced protein, has been reported in malignancies and functions as an oncogene by modulating the stress response, facilitating survival in harsh environments and conferring drug resistance. However, its role in ccRCC has not been explored.

Methods: The expression and clinical significance of NUPR1 were analyzed in ccRCC patients in in-house patients and The Cancer Genome Atlas (TCGA) cohorts. The biological functions of NUPR1 were investigated. Xenografts were performed to confirm the effects of NUPR1 on tumorigenesis. The molecular mechanism of NUPR1 was investigated and .

Results: NUPR1 expression was upregulated in tumor tissue. Further analysis showed that NUPR1 overexpression was associated with an aggressive phenotype and predicted a poor prognosis. Depletion of NUPR1 suppressed tumorigenesis and sensitized cells to sorafenib treatment. Finally, mechanistic investigations indicated that NUPR1 promoted tumorigenesis in ccRCC by increasing stemness and activating the PTEN/AKT/mTOR signaling pathway.

Conclusions: Collectively, our results suggest that NUPR1 may serve as a predictor of ccRCC. Notably, NUPR1 silencing reversed sorafenib resistance in ccRCC. These findings provide a novel potential therapeutic target in the clinical management of ccRCC.
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http://dx.doi.org/10.18632/aging.203012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8202846PMC
May 2021

Serratus Anterior Plane Block Combined with General Analgesia and Patient-Controlled Serratus Anterior Plane Block in Patients with Breast Cancer: A Randomized Control Trial.

Adv Ther 2021 06 22;38(6):3444-3454. Epub 2021 May 22.

Department of Anesthesiology, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, No.1 Panfu Road, Yuexiu District, Guangzhou, 510180, Guangdong, China.

Introduction: Anterior serratus muscle plane block is a novel regional block technique for blockade of the sensory plane of the lateral cutaneous branch of the intercostal nerve (T2-T9), which effectively relieves the pain of patients and improves the quality of recovery. This study aimed to observe the early effectiveness and safety of serratus anterior plane block combined with general anesthesia and patient-controlled serratus anterior plane block in early postoperative recovery in breast cancer.

Methods: The study involved a total of 84 patients undergoing radical mastectomy in our hospital. The patients were randomly divided into three groups: the serratus anterior block + general anesthesia + patient-controlled serratus anterior plane block group (PCSAPB group), the serratus anterior block + general anesthesia + patient-controlled intravenous analgesia group (PCIA group), and the general anesthesia + PCIA group (control group), with n = 28 cases in each group.

Results: The visual analogue scale (VAS) scores of the three groups were compared before and after the operation (P < 0.001), and the anxiety visual analogue scale (AVAS) scores after operation were compared among the three groups (P < 0.001). The total number of postoperative analgesic pumps in the PCSAPB group was significantly lower than that in the control group (P < 0.05). The incidence of adverse reactions in the three groups was statistically significant (P < 0.05).

Conclusion: The combination of anterior serratus plane block and general anesthesia and patient-controlled anterior serratus plane block reduced pain and adverse events, alleviating anxiety, improving the quality of early postoperative recovery among patients with breast cancer after modified radical mastectomy.
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http://dx.doi.org/10.1007/s12325-021-01782-yDOI Listing
June 2021

Ligand-Conformer-Induced Formation of  Zirconium-Organic Framework  for Methane Storage and MTO Product Separation.

Angew Chem Int Ed Engl 2021 May 21. Epub 2021 May 21.

Shaanxi Normal University, School of Chemistry and Chemical Engineering, CHINA.

In pursuit of novel adsorbents with efficient adsorptive gas storage and separation capabilities remains highly desired and challenging. Although the documented zirconium-tricarboxylate-based metal-organic frameworks (MOFs) have displayed a variety of topologies encompassing underlying and geometry mismatch ones, the employed organic linkers are exclusively rigid and poorly presenting one type of conformation in the resultant structures. Herein, a used and semirigid tricarboxylate ligand of H3TATAB was judiciously selected to isolate a zirconium-based spe-MOF after the preliminary discovery of srl-MOF. Single-crystal X-ray diffraction reveals that the fully deprotonated TATAB linker in spe-MOF exhibits two distinct conformers, concomitant with popular Oh and rare S6 symmetrical Zr6 molecular building blocks, generating an unprecedented (3,3,12,12)-c nondefault topology. Specifically, the spe-MOF exhibits structurally higher complexity, hierarchical micropores, open metal sites free and rich electronegative groups on the pore surfaces, leading to relatively high methane storage capacity without considering the missing-linker defects and efficient MTO product separation performance.
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http://dx.doi.org/10.1002/anie.202103525DOI Listing
May 2021

Label-Free Quantitative Proteomic Analysis of Three Strains of Viscerotropic Leishmania Isolated from Patients with Different Epidemiological Types of Visceral Leishmaniasis in China.

Acta Parasitol 2021 May 21. Epub 2021 May 21.

National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research), NHC Key Laboratory of Parasite and Vector Biology, WHO Collaborating Centre for Tropical Diseases, National Center for International Research on Tropical Diseases, Ministry of Health, Shanghai, 200025, China.

Background: There are three epidemiological types of visceral leishmaniasis in China, which are caused by Leishmania strains belonging to the L. donovani complex. The mechanisms underlying their differences in the population affected, disease latency, and animal host, etc., remain unclear. We investigated the protein abundance differences among Leishmania strains isolated from three types of visceral leishmaniasis endemic areas in China.

Methods: Promastigotes of the three Leishmania strains were cultured to the log phase and harvested. The protein tryptic digests were analyzed with liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI-MS/MS), followed by label-free quantitative analysis. The MS experiment was performed on a Q Exactive mass spectrometer. Raw spectra were quantitatively analyzed with the MaxQuant software (ver 1.3.0.5) and matched with the reference database. Differentially expressed proteins were analyzed using the bioinformatics method. The MS analysis was repeated three times for each sample.

Results: A total of 5012 proteins were identified across the KS-2, JIASHI-5 and SC6 strains in at least 2 of the three samples replicate. Of them, 1758 were identified to be differentially expressed at least between 2 strains, including 349 with known names. These differentially expressed proteins with known names are involved in biological functions such as energy and lipid metabolic process, nucleotide acid metabolic process, amino acid metabolic process, response to stress, cell membrane/cytoskeleton, cell cycle and proliferation, biological adhesion and proteolysis, localization and transport, regulation of the biological process, and signal transduction.

Conclusion: The differentially expressed proteins and their related biological functions may shed light on the pathogenicity of Leishmania and targets for the development of vaccines and medicines.
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http://dx.doi.org/10.1007/s11686-021-00387-3DOI Listing
May 2021

Spectral-Domain Optical Coherence Tomography Imaging of the Typical cystoid degeneration.

Semin Ophthalmol 2021 May 16:1-4. Epub 2021 May 16.

Department of Retina Center, Eye Hospital of Wenzhou Medical University, Hangzhou, Zhejiang Province, China.

To describe the spectral-domain optical coherence tomography (SD-OCT) features of typical cystoid degeneration. This was a retrospective study of 11 eyes with typical cystoid degeneration (TCD). All patients had a complete ocular examination, ultra-widefield (UWF) pseudocolor fundus photography and SD-OCT with a 55° wide-field lens. We analyzed the cross-sectional structural information of SD-OCT imaging with TCD. On SD-OCT, the TCD regions exhibited rolling hills patterns with irregularly elevated retinal surface, and multiple intraretinal hyporeflective cavities separated by irregular septums were seen in the neurosensory retina. Destructive changes were seen in the ellipsoid zone and the pigment epithelium. Consolidated vitreous with moderate to high reflectivity was seen over the lesion and there might be vitreoretinal adhesions and tractions. SD-OCT shows exquisite structural features of the anatomy in vivo detail of the TCD. This imaging technique may deepen our structural understanding of TCD and may influence decision-making in clinical practice.
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http://dx.doi.org/10.1080/08820538.2021.1913191DOI Listing
May 2021

Histone deacetylase 10, a potential epigenetic target for therapy.

Biosci Rep 2021 Jun;41(6)

Department of Urology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, P.R. China.

Histone deacetylase (HDAC) 10, a class II family, has been implicated in various tumors and non-tumor diseases, which makes the discovery of biological functions and novel inhibitors a fundamental endeavor. In cancers, HDAC10 plays crucial roles in regulating various cellular processes through its epigenetic functions or targeting some decisive molecular or signaling pathways. It also has potential clinical utility for targeting tumors and non-tumor diseases, such as renal cell carcinoma, prostate cancer, immunoglobulin A nephropathy (IgAN), intracerebral hemorrhage, human immunodeficiency virus (HIV) infection and schizophrenia. To date, relatively few studies have investigated HDAC10-specific inhibitors. Therefore, it is important to study the biological functions of HDAC10 for the future development of specific HDAC10 inhibitors. In this review, we analyzed the biological functions, mechanisms and inhibitors of HDAC10, which makes HDAC10 an appealing therapeutic target.
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http://dx.doi.org/10.1042/BSR20210462DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8182986PMC
June 2021

Postoperative follow-up strategy based on event dynamics for esophageal squamous cell carcinoma.

Ann Transl Med 2021 Apr;9(8):699

Fujian Key Laboratory of Cardiothoracic Surgery (Fujian Medical University), Fuzhou, China.

Background: Despite the improvements in radical surgery for esophageal squamous cell carcinoma (ESCC), a large number of patients still develop recurrence. This research sought to graphically depict patterns in ESCC recurrence following curative surgical treatment using event dynamics and clarify approaches to postsurgical follow-up on the basis of recurrence time.

Methods: This study included 717 individuals with ESCC who received radical surgery in the Thoracic Department at Fujian Medical University Union Hospital between 2013 and 2016. Event dynamics analysis was performed on the basis of hazard rates. An initial event was defined as the occurrence of local recurrence, distant metastasis, or both.

Results: After complete resection, patients were followed up for a median of 44 months (range, 2-83 months). A total of 223 (31.1%) patients developed recurrence, including 122 (17.0%) patients who developed only locoregional recurrence, and 101 (14.1%) patients who developed only distant metastasis or both locoregional recurrence and distant metastasis. Recurrences were concentrated mainly (98.2%) in the first 4 years of follow-up among all recurrences, with 100 cases (44.8%) in the first year, 69 cases (30.9%) in the second year, and 50 cases (22.4%) in the third and fourth years.

Conclusions: After curative surgery in a multimodal setting, a significant number of patients still experienced recurrence within 4 years after surgery, which suggests that current postoperative esophageal cancer follow-up strategies may need to be modified.
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http://dx.doi.org/10.21037/atm-21-1373DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8106059PMC
April 2021

Current status of simulation usage in Canadian cardiac surgery training programs.

Can J Cardiol 2021 May 5. Epub 2021 May 5.

Department of Surgery, University of Alberta, Edmonton, Alberta.

The apprenticeship model of surgical education, relying solely on operating room training, may be insufficient to meet current needs of cardiac surgery trainees. Challenges such as resident duty hour restrictions, increasing case complexity, and novel techniques limit direct intraoperative experience. Simulation is a widely accepted educational tool in surgery. The purpose of this study was to establish an understanding of the current use of simulation in Canadian cardiac surgery, and to examine the attitudes of Canadian educators and residents towards simulation training. Canadian cardiac surgery residents and faculty surgeons were surveyed at each of the 12 Canadian academic institutions. Simulation was used at all 12 academic programs with the average use being 3-4 times a year. The most common simulators used were anastomotic task trainers and porcine heart models. Simulation sessions were deemed incomplete, lacking clearly stated learning objectives and evaluations. There was an overall desire from both residents and faculty surgeons to have more simulation use at their centre. This study identified that while simulation is employed and valued within Canada, it is not yet employed to maximum potential. Simulation cannot replace operative experience, but current demands on surgeons and residents mandates a broader, more effective application of simulation as an educational adjunct.
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http://dx.doi.org/10.1016/j.cjca.2021.04.020DOI Listing
May 2021

Cost-Effectiveness Analysis of Olaparib Maintenance Treatment for Germline BRCA-Mutated Metastatic Pancreatic .

Front Pharmacol 2021 20;12:632818. Epub 2021 Apr 20.

Department of Pharmacy, Fujian Medical University Union Hospital, Fuzhou, China.

The PARP inhibitor olaparib has been shown to have clinical efficacy in patients with a germline BRCA mutation and ovarian or breast cancer. However, the high treatment cost associated with this drug limits its viability as a clinical treatment option. This work aims to evaluate the cost-effectiveness of olaparib as a maintenance treatment for metastatic pancreatic cancer from the perspective of the United States and China healthcare systems and provides valuable suggestions for clinical decision making. A three-state Markov model (progression-free, progressed disease, death) was constructed using TreeAge Pro 2020 software to evaluate the economic value of olaparib vs. placebo maintenance treatment for metastatic pancreatic cancer based on the clinical data derived from phase III randomized controlled trial (POLO, ClinicalTrials.gov number, NCT02184195). Total costs, quality-adjusted life years and incremental cost-effectiveness ratio were used as economic indicators for this analysis. A 5-years horizon and 5%/year discount rates were used. One-way sensitivity analysis and probabilistic sensitivity analysis (PSA) were performed to assess the model uncertainty. The incremental cost-effectiveness ratios (ICERs) of the use of olaparib vs. placebo in China and the United States were $6,694/QALY and $13327/QALY, respectively. All ICERs were far below the thresholds of $30829 in China and $50000 in the United States. Sensitivity analysis confirmed a stable economic advantage in the use of olaparib vs. placebo as maintenance therapy in China and the United States. Olaparib was estimated to be more cost effective than placebo for the maintenance therapy of patients with a germline BRCA mutation and pancreatic cancer in China and the United States at thresholds of $30829 and $50000 per QALY, respectively.
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http://dx.doi.org/10.3389/fphar.2021.632818DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8096350PMC
April 2021

Management of Vasoproliferative Tumors of the Retina with Macular Complications by Pars Plana Vitrectomy Combined with Episcleral Cryotherapy.

J Ophthalmol 2021 13;2021:6667755. Epub 2021 Apr 13.

Henan Eye Institute, Henan Eye Hospital, Henan Provincial People's Hospital and Henan University People's Hospital, Zhengzhou 450003, Henan, China.

Objective: To evaluate the efficacy of pars plana vitrectomy (PPV) combined with episcleral cryotherapy in treating vasoproliferative tumors of the retina (VPTR) with macular complications.

Methods: In this retrospective noncomparative interventional case-series analysis, we included 11 eyes of ten patients diagnosed with VPTR. All patients underwent comprehensive ophthalmic examinations and were treated with PPV combined with episcleral cryotherapy. Best-corrected visual acuity (BCVA), tumor activity, retinal morphological structure, and postoperative complications were evaluated.

Results: Macular complications included epimacular membrane ( = 10), macular hole ( = 3), and macular edema ( = 1). Tumors were treated with triple freeze-thaw episcleral cryotherapy during PPV. The mean logarithm of minimal angle of resolution (logMAR) BCVA dropped from 0.62 ± 0.58 to 0.39 ± 0.46. The difference between the mean values of logMAR BCVA before and after treatment was statistically significant ( = 2.48, =0.033). The tumor activity was controlled effectively in nine cases. Compared with preoperative tumor activity, tumor activity after treatment was significantly lower ( < 0.01). The increase of central retinal thickness and the disruption of retinal layers were associated with macular holes, macular edema, and retinal proliferative membrane. After the treatment, visual acuity improved in 91% of the cases, and 73% had no long-term complications.

Conclusion: PPV combined with episcleral cryotherapy promoted tumor regression, preserved retinal integrity, and improved visual acuity. Thus, the combination of PPV with episcleral cryotherapy can be considered effective and safe for the management of VPTR with macular complications.
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http://dx.doi.org/10.1155/2021/6667755DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8057872PMC
April 2021

A novel loop-mediated isothermal amplification-lateral-flow-dipstick (LAMP-LFD) device for rapid detection of Toxoplasma gondii in the blood of stray cats and dogs.

Parasite 2021 3;28:41. Epub 2021 May 3.

Department of Immunity and Biochemistry, Institute of Parasitic Disease, Zhejiang Academy of Medical Sciences 310013 Hangzhou PR China - Hangzhou Medical College 310053 Hangzhou PR China.

Toxoplasma gondii is an obligate intracellular protozoan parasite that causes toxoplasmosis and threatens warm-blooded animal and human health worldwide. Simple and applicable diagnostic methods are urgently needed to guide development of effective approaches for prevention of toxoplasmosis. Most molecular diagnostic tools for T. gondii infection require high technical skills, sophisticated equipment, and a controlled lab environment. In this study, we developed a loop-mediated isothermal amplification-lateral-flow-dipstick (LAMP-LFD) assay that specifically targets the 529 bp for detecting T. gondii infection. This novel portable device is universal, fast, user-friendly, and guarantees experimental sensitivity as well as low risk of aerosol contamination. Our LAMP-LFD assay has a detection limit of 1 fg of T. gondii DNA, and shows no cross-reaction with other parasitic pathogens, including Cryptosporidium parvum, Leishmania donovani, and Plasmodium vivax. We validated the developed assay by detecting T. gondii in DNA extracted from blood samples collected from 318 stray cats and dogs sampled from Deqing, Wenzhou, Yiwu, Lishui and Zhoushan cities across Zhejiang province, Eastern China. The LAMP-LFD device detected T. gondii DNA in 4.76 and 4.69% of stray cats and dogs, respectively. In conclusion, the developed LAMP-LFD assay is efficient, minimizes aerosol contamination, and is therefore suitable for detecting T. gondii across basic medical institutions and field settings.
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http://dx.doi.org/10.1051/parasite/2021039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8095094PMC
May 2021

Sendai virus-based immunoadjuvant in hydrogel vaccine intensity-modulated dendritic cells activation for suppressing tumorigenesis.

Bioact Mater 2021 Nov 13;6(11):3879-3891. Epub 2021 Apr 13.

Academy of Medical Engineering and Translational Medicine, Tianjin Key Laboratory of Brain Science and Neural Engineering, Tianjin University, 92 Weijin Road, Nankai District, Tianjin, 300072, China.

The conventional immunoadjuvants in vaccine have weak effect on stimulating antigen presentation and activating anti-tumor immunity. Unexpectedly, we discovered that non-pathogenic Sendai virus (SeV) could activate antigen-presenting cells (APCs) represented by dendritic cells (DCs). Here, we designed an injectable SeV-based hydrogel vaccine (SHV) to execute multi-channel recruitment and stimulation of DCs for boosting the specific immune response against tumors. After the release of the NIR-triggered antigens from tumor cells, dendritic cells around the vaccine efficiently transport the antigens to lymph nodes and present them to T lymphocytes, thereby inducing systemic anti-tumor immune memory. Our findings demonstrated that the SHV with excellent universality, convenience and flexibility has achieved better immune protection effects in inhibiting the occurrence of melanoma and breast cancer. In conclusion, the SHV system might serve as the next generation of personalized anti-tumor vaccines with enhanced features over standard vaccination regimens, and represented an alternative way to suppress tumorigenesis.
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http://dx.doi.org/10.1016/j.bioactmat.2021.04.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8076650PMC
November 2021

Protective effects of molecular hydrogen on lung injury from lung transplantation.

Exp Biol Med (Maywood) 2021 Apr 25:15353702211007084. Epub 2021 Apr 25.

Department of Anesthesiology, Fourth Affiliated Hospital of Harbin Medical University, Harbin 150001, China.

Lung grafts may experience multiple injuries during lung transplantation, such as warm ischaemia, cold ischaemia, and reperfusion injury. These injuries all contribute to primary graft dysfunction, which is a major cause of morbidity and mortality after lung transplantation. As a potential selective antioxidant, hydrogen molecule (H) protects against post-transplant complications in animal models of multiple organ transplantation. Herein, the authors review the current literature regarding the effects of H on lung injury from lung transplantation. The reviewed studies showed that H improved the outcomes of lung transplantation by decreasing oxidative stress and inflammation at the donor and recipient phases. H is primarily administered via inhalation, drinking hydrogen-rich water, hydrogen-rich saline injection, or a hydrogen-rich water bath. H favorably modulates signal transduction and gene expression, resulting in the suppression of pro-inflammatory cytokines and excess reactive oxygen species production. Although H appears to be a physiological regulatory molecule with antioxidant, anti-inflammatory and anti-apoptotic properties, its exact mechanisms of action remain elusive. Taken together, accumulating experimental evidence indicates that H can significantly alleviate transplantation-related lung injury, mainly via inhibition of inflammatory cytokine secretion and reduction in oxidative stress through several underlying mechanisms. Further animal experiments and preliminary human clinical trials will lay the foundation for the use of H as a treatment in the clinic.
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http://dx.doi.org/10.1177/15353702211007084DOI Listing
April 2021

Cisplatin resistance reversal in lung cancer by tumor acidity-activable vesicular nanoreactors via tumor oxidative stress amplification.

J Mater Chem B 2021 04 22;9(13):3055-3067. Epub 2021 Mar 22.

CAS Key Laboratory of Soft Matter Chemistry, Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei 230026, Anhui, China.

Drug resistance of cisplatin significantly limits its therapeutic efficacy in clinical applications against different cancers. Herein, we develop a novel strategy to overcome cisplatin drug resistance through sensitizing cisplatin-resistant human lung cancer cells (A549R) under amplified oxidative stress using a vesicular nanoreactor for simultaneous cisplatin delivery and HO generation. We engineer the nanoreactor by the self-assembly of the amphiphilic diblock copolymers to co-deliver glucose oxidase (GOD) and cisplatin (Cis) (Cis/[email protected]). Cis/[email protected] was rationally designed to stay impermeable during blood circulation while mild acidity (pH 6.5-6.8) can activate its molecular-weight selective membrane permeability and release cisplatin locally. Diffusion of small molecules such as oxygen and glucose across the membranes can induce the in situ generation of superfluous HO to promote cellular oxidative stress and sensitize A549R cells via activation of pro-apoptotic pathways. Cis/[email protected] nanoreactors could effectively kill A549R at pH 6.8 in the presence of glucose by the combination of HO generation and cisplatin release. Growth of A549R xenograft tumors can be inhibited efficiently without the obvious toxic side effects via the systemic administration of Cis/[email protected] Accordingly, the tumor acidity-activable cisplatin-loaded nanoreactors show great potential to enhance the therapeutic efficacy against cisplatin-resistant cancers.
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http://dx.doi.org/10.1039/d0tb02876bDOI Listing
April 2021

circACTA2 mediates Ang II-induced VSMC senescence by modulation of the interaction of ILF3 with CDK4 mRNA.

Aging (Albany NY) 2021 04 22;13(8):11610-11628. Epub 2021 Apr 22.

Department of Biochemistry and Molecular Biology, Key Laboratory of Neural and Vascular Biology, Ministry of Education, Hebei Medical University, Shijiazhuang 050017, China.

Chronic angiotensin II (Ang II) stimulation induces vascular smooth muscle cell (VSMC) senescence, and circRNAs and members of the ILF3 family are implicated in cellular senescence, but the mechanism underlying regulation of circRNAs and ILF3 by Ang II in VSMCs remains poorly understood. Here, a model of Ang II-induced VSMC senescence and the renal artery of hypertensive patients were used to investigate the roles and mechanisms of circACTA2 and ILF3 in VSMC senescence. We show that circACTA2 expression was elevated in Ang II-stimulated VSMCs and in the vascular walls of hypertensive patients. circACTA2 knockdown largely abrogated Ang II-induced VSMC senescence as shown by decreased p21 expression and increased CDK4 expression as well as by decreased SA β-gal-positive cells. Oligo pull-down and RIP assays revealed that both circACTA2 and CDK4 mRNA could bind with ILF3, and Ang II facilitated circACTA2 association with ILF3 and attenuated ILF3 interaction with CDK4 mRNA. Mechanistically, increased circACTA2 by Ang II reduced ILF3 association with CDK4 mRNA by competing with CDK4 mRNA to bind to ILF3, which decreases CDK4 mRNA stability and protein expression, thus leading to Ang II-induced VSMC senescence. Targeting the circACTA2-ILF3-CDK4 axis may provide a novel therapeutic strategy for VSMC senescence-associated cardiovascular diseases.
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http://dx.doi.org/10.18632/aging.202855DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8109074PMC
April 2021

Therapeutic Repurposing of Biguanides in Cancer.

Trends Cancer 2021 Apr 14. Epub 2021 Apr 14.

Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA. Electronic address:

Biguanides are a class of antidiabetic drugs that includes phenformin and metformin; however, the former was withdrawn from approval in many countries due to its toxicity. Findings from retrospective epidemiological studies in diabetic populations and preclinical laboratory models have demonstrated that biguanides possess antitumor activities that suggest their repurposing for cancer prevention and treatment. However, a better understanding of how these biguanides behave as antitumor agents is needed to guide their improved applications in cancer therapy, spurring increased interest in their pharmacology. Here, we present evidence for proposed mechanisms of action related to their antitumor activity, including their effects on central carbon metabolism in cancer cells and immune-modulating activity, and then review progress on biguanide repurposing in cancer therapeutics and the possible re-evaluation of phenformin as a cancer therapeutic agent.
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http://dx.doi.org/10.1016/j.trecan.2021.03.001DOI Listing
April 2021