Publications by authors named "Bin Zhao"

1,695 Publications

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Anchoring Ag(I) into Nitro-Functionalized Metal-Organic Frameworks: Effectively Catalyzing Cycloaddition of CO with Propargylic Alcohols under Mild Conditions.

ACS Appl Mater Interfaces 2021 Sep 15. Epub 2021 Sep 15.

Department of Chemistry, Key Laboratory of Advanced Energy Material Chemistry, MOE, and Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Nankai University, Tianjin 300071, China.

Carboxylative cyclization of propargylic alcohols with CO is significant in synthetic chemistry, but harsh conditions are often needed according to reported results. Herein, a new stable nitro-functionalized metal-organic framework (MOF) of {[Co(L)(bpy)(HO)]·DMF·HO·bpy} () was fabricated through the solvothermal reaction, which exhibited excellent stability in acid and basic solutions. Owing to the porous structure, unsaturated metal sites, and uncoordinated 4,4'-bpy ligands, can serve as an excellent platform for catalytic applications. Hence, Ag(I) ions were incorporated in through a postsynthetic method, and the as-synthesized Ag- catalyst with low metal loading (0.64 mol %) displayed excellent catalytic performance in the chemical fixation of CO with alkynols under room temperature and atmospheric pressure. The results of H NMR analyses further confirmed that Ag- can efficiently activate hydroxyl groups and promote the reaction. Moreover, the turnover frequency (TOF) of the Ag- catalyst can reach 262 h in a short period of time, which is a high TOF value among the state-of-the-art MOF-based catalysts for catalyzing cycloaddition of CO with propargylic alcohols.
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http://dx.doi.org/10.1021/acsami.1c13438DOI Listing
September 2021

Mid- and Long-Term Follow-Up Efficacy Analysis of 3D-Printed Interbody Fusion Cages for Anterior Cervical Discectomy and Fusion.

Orthop Surg 2021 Sep 15. Epub 2021 Sep 15.

Department of Orthopaedics, The Second Hospital of Shanxi Medical University, Taiyuan, China.

Objective: To evaluate the safety and stability of 3D-printed interbody fusion cages (3D-printed cages) in anterior cervical discectomy and fusion (ACDF) by investigating the mid- and long-term follow-up outcomes.

Methods: In this prospective study, the clinical data of 30 patients with CSM admitted to the Second Hospital of Shanxi Medical University from May 2012 to May 2014 were analyzed. The cohort comprised 18 males and 12 females with an average age of 60.22 ± 3.2 years. All patients were examined by X-ray, CT and MRI before the operation. A total of 30 cases of CSM were treated by ACDF with 3D printed cage implantation. Mid- and long-term follow-ups were performed after the surgery. Clinical efficacy was evaluated by comparing the JOA score, SF-36 score, change in neurological function, cervical curvature index (CCI), vertebral intervertebral height (VIH) and fusion rate before the operation, 6 months after the operation, and at the last follow-up.

Results: Two of the 30 patients were lost to follow-up. The remaining patients were followed up for 48-76 (65.23 ± 3.54) months. The patients recovered satisfactorily with a significant clinical effect. The JOA score increased meanfully and the improvement rate was 89.4% at the final follow-up. The SF-36 score increased significantly from pre- to postoperatively. The height of the intervertebral space at the last follow-up was not statistically significantly different from that at 6 months after surgery (P > 0.05), showing that the height of the intervertebral space did not change much and the severity of cage subsidence (CS) decreased. The CCI improved from pre- to postoperatively. The CCI did not change much from the 6-month follow-up to the last follow-up. and the cage rate (CR) was 100% at the 6-month and last follow-ups. No severe complications, such as spinal cord injury, esophageal fistula, cerebrospinal fluid leakage, cervical hematoma or wound infection, occurred in any of the patients.

Conclusion: The clinical and radiological results show that the application of 3D-printed cages in ACDF can significantly relieve symptoms. Moreover, 3D-printed cages can restore the curvature of the cervical spine, effectively maintain the intervertebral height for a long time, and prevent complications related to postoperative subsidence.
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http://dx.doi.org/10.1111/os.13005DOI Listing
September 2021

Correlation Analysis for Selection of Microtitanium Plates with Different Specifications for Use in a Cervical Vertebral Dome Expansion Laminoplasty.

Orthop Surg 2021 Sep 15. Epub 2021 Sep 15.

The Second Affiliated Hospital of Shanxi Medical University, Taiyuan, China.

Objective: To analyze correlations between the selection of microtitanium plates with different specifications for use in a cervical vertebral dome expansion laminoplasty.

Methods: Sixteen patients that underwent the cervical vertebral dome expansion laminoplasty with a cervical spinal stenosis angioplasty procedure for treatment of their cervical spinal cords were recruited at our hospital. From February 2017 to September 2018, medical records confirmed that all patients underwent cervical CT and MRI tests pre- and postsurgery. The anteroposterior diameter of the spinal canal, changes in the cross-sectional area of the spinal canal, and the pre- and postsurgery distance of the cervical spinal cord after applying microtitanium plates with different lengths were measured by Mimics version 17.0 software (Materialise NV, Leuven, Belgium). A statistical regression and correlation analysis of relevant specification parameters of the microtitanium plate was then studied.

Results: As the size of the microtitanium plate increased, we found that the cross-sectional area of cervical spinal canal and distance between the descendants of the lamina and the distance of cervical spinal cord concordantly increased, and these data changes linearly. The regression equation associated with sagittal diameter, cross-sectional area, and posterior movement distance of the cervical spinal cord was obtained.

Conclusion: According to the correlation analysis of imaging data changes, the regression equation was obtained to guide the selection of microtitanium plates with appropriate specifications in a cervical vertebral dome expansion laminoplasty.
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http://dx.doi.org/10.1111/os.13102DOI Listing
September 2021

Forward osmosis treatment of algal-rich water: Characteristics and mechanism of membrane fouling.

J Hazard Mater 2021 Aug 21;423(Pt A):126984. Epub 2021 Aug 21.

State Key Laboratory of Separation Membranes and Membrane Processes, School of Environmental Science and Engineering, Tiangong University, Tianjin 300387, China.

Membrane fouling is an inevitable problem in forward osmosis (FO) treatment of algal-rich water (ARW). Natural ARW has a complex composition. Therefore, the coexisting components (Ca, natural organic humic acid [HA], and inorganic particulate kaolinite) in the influence of ARW on FO membrane fouling were studied. The analysis of extended Derjaguin-Landau-Verwey-Overbeek theory and the confocal laser scanning microscopy revealed that the addition of coexisting components increased the attraction between pollutants and membranes, as well as among pollutants to varying degrees, and promoted the development of membrane fouling. Furthermore, Ca and HA aggravated irreversible membrane fouling. All coexisting components changed the distribution and thickness of the fouling layer, and the addition of Ca increased the content of extracellular organic matter (proteins and polysaccharides). The present results enhance the understanding of the mechanism through which natural ingredients affect microalgal membrane fouling and provide a basis for membrane fouling control to treat ARW.
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http://dx.doi.org/10.1016/j.jhazmat.2021.126984DOI Listing
August 2021

Two-staged posterior osteotomy surgery in complex and rigid congenital scoliosis in younger than 10 years old children.

BMC Musculoskelet Disord 2021 Sep 13;22(1):788. Epub 2021 Sep 13.

Department of Orthopedics, The Second Hospital of Shanxi Medical University, No. 382 Wuyi Road, Shanxi, 030001, Taiyuan, P.R. China.

Background: Congenital scoliosis caused by failure of multiply vertebral segmentation with concave fused rib or unsegmented bar combined with contralateralhemivertebra is usually rigid and produces enormous asymmetric growth. Fusionless techniques have less advantage and come with some complications. Paucity of data was reported for children with complex congenital scoliosis using two-staged osteotomy surgery.

Methods: From 2006 to 2016, 11 patients less than 10 years old undergoing two staged osteotomy surgery for complex rigid congenital scoliosis were retrospectively reviewed. The analysis included age at initial surgery, second surgery and at the latest follow-up, and complications. Changes in coronal major curve, thoracic kyphosis, lumbar lodorsis, apex vertebra translation, T1-T12 length, T1-S1 length, trunk shift, and SVAwere included in radiological evaluation.

Results: In all, the mean follow-up was 72.5 ± 23.8 (42 to 112) months. The mean flexibility of the spine was 17.4 and 17.8 % before two surgeries. The mean age at the initial surgery was 6.6 ± 2.6 (2.5-10) years. The mean fusion level was 4.6 ± 1.3 (2 to 6) segments. The mean scoliosis improved from 67.4° to 23.7° after initial surgery and was 17.4° at the latest follow-up. The average increase of T1-S1 length was 0.92 cm per year. No patients had neurological complications.

Conclusions: Two-staged osteotomy surgery including hemivertebrae resection or Y-shaped osteotomy can achieve good radiological and clinical outcomes without severe complications. This procedure can be an option of treatment for complex congenital scoliosis.
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http://dx.doi.org/10.1186/s12891-021-04682-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8439016PMC
September 2021

Enhanced struvite generation and separation by magnesium anode electrolysis coupled with cathode electrodeposition.

Sci Total Environ 2021 Sep 7;804:150101. Epub 2021 Sep 7.

State Key Laboratory of Environmental Aquatic Chemistry, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China; University of Chinese Academy of Sciences, Beijing 100049, China; Jiangsu Collaborative Innovation Center of Technology and Material of Water Treatment, Suzhou University of Science and Technology, Suzhou 215009, China. Electronic address:

Adding magnesium ions (Mg) to produce struvite is an important method to recover nitrogen and phosphorus from wastewater. Both the Mg source and subsequent separation of struvite are key factors for the utilization of struvite. In this study, we developed an efficient method to recover nutrient salts from wastewater using sacrificial Mg anodes to generate struvite, with its simultaneous separation through cathode electrodeposition. The anode-released Mg reacted with NH-N and PO-P in bulk solution to form struvite, which was more intense on the cathode surface due to the relatively higher pH environment from hydrogen evolution, resulting in most of the struvite being deposited on the cathode surface and simultaneously separated out of the bulk solution. Using a cathode with a higher solution-cathode interface area and relatively low current density facilitated struvite deposition. Results showed that under optimal electrolysis condition (5.76 A/m, pH 8.5, 180 min, and 1.2:1.0 Mg:P), 91% of the undissolved substances as the phosphate precipitation were deposited on the graphite cathode surface, and the proportion of struvite in the deposition reached 41.52%. This study provides a novel electrochemical method for struvite synthesis and separation for the recovery of nitrogen and phosphorus from wastewater.
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http://dx.doi.org/10.1016/j.scitotenv.2021.150101DOI Listing
September 2021

Integrative Analysis Identified MCT4 as an Independent Prognostic Factor for Bladder Cancer.

Front Oncol 2021 26;11:704857. Epub 2021 Aug 26.

Department of Urology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Background: Bladder cancer is the 10th most common cancer and most common urothelial malignancy worldwide. Prognostic biomarkers for bladder cancer patients are required for individualized treatment. Monocarboxylate transporter 4 (MCT4), encoded by gene, is a potential biomarker for bladder cancer because of its crucial role in the lactate efflux in the aerobic glycolysis process. We aimed to study the association between MCT4 expression and the overall survival (OS) of bladder cancer patients.

Methods: The published single-cell RNA sequencing data of 49,869 bladder cancer cells and 15,827 normal bladder mucosa cells and The Cancer Genome Atlas (TCGA) bladder cancer cohort data were used to explore the mRNA expression of SLC16A3 in bladder cancer. Eighty-nine consecutive bladder cancer patients who had undergone radical cystectomy were enrolled as a validation cohort. The expression of MCT4 proteins in bladder cancer specimens was detected using immunohistochemistry staining. The Kaplan-Meier survival analysis and Cox regression were performed to analyze the association between MCT4 protein expression and OS in bladder cancer patients.

Results: SLC16A3 mRNA was upregulated in bladder cancer cells. The upregulated genes in SLC16A3-positive epithelial cells were enriched in the glycolysis process pathway and monocarboxylic acid metabolic process pathway. Patients with high SLC16A3 mRNA expression showed significantly poor OS (p = 0.016). High MCT4 protein expression was also found to be an independent predictor for poor OS in bladder cancer patients (HR: 2.462; 95% CI: 1.202~5.042, p = 0.014). A nomogram was built based on the results of the multivariate Cox analysis.

Conclusion: Bladder cancer with high SLC16A3 mRNA expression has a poor OS. High MCT4 protein expression is an independent prognostic factor for bladder cancer patients who had undergone radical cystectomy.
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http://dx.doi.org/10.3389/fonc.2021.704857DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8426349PMC
August 2021

Downregulation of miR-23b by transcription factor c-Myc alleviates ischemic brain injury by upregulating Nrf2.

Int J Biol Sci 2021 26;17(13):3659-3671. Epub 2021 Aug 26.

Jilin University, Changchun 130000, P. R. China.

Ischemic brain injury (IBI) is a common acute cerebral vessel disease that occurs secondary to blockage in arteries, mainly characterized by insufficient blood supply to the brain. The transcription factor c-Myc in IBI continues to be implicated in numerous studies. This study was conducted with emphasis placed on the underlying mechanism of c-Myc in IBI. Clinical samples were collected from IBI patients. Middle cerebral artery occlusion (MCAO) was induced in mice by inserting a suture from the external carotid artery to the anterior cerebral artery through the internal carotid artery to mechanically block the blood supply at the origin of the middle cerebral artery, and cortical neurons from mice were exposed to oxygen glucose deprivation (OGD) conditions for IBI model construction. RT-qPCR was performed to determine microRNA-23b (miR-23b) expression. TUNEL staining and Western blot analysis was conducted to detect apoptosis. The regulatory relationship was analyzed by dual-luciferase reporter gene assay. After loss- and gain-of-function assays, triphenyltetrazolium chloride staining was carried out to detect the area of cerebral infarction, after which the spatial memory in mice was evaluated with Morris water maze test. As per our findings, miR-23b was upregulated in the serum of IBI patients and OGD-treated murine primary neurons. Silencing of miR-23b resulted in reduced OGD-induced neuronal apoptosis. miR-23b inversely targeted nuclear factor erythroid 2-related factor 2 (Nrf2) and c-Myc negatively regulated miR-23b expression. Overexpression of c-Myc and inhibition of miR-23b led to reduced neurological scores of infarction area, neuronal apoptosis, shortened platform arrival time and significantly increased the time spent on the platform quadrant and the times of crossing the platform . Collectively, downregulated miR-23b by c-Myc might alleviate IBI by upregulating Nrf2.
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http://dx.doi.org/10.7150/ijbs.61399DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8416714PMC
August 2021

Fabrication of CoO-BiO-Ti catalytic membrane for efficient degradation of organic pollutants in water by peroxymonosulfate activation.

J Colloid Interface Sci 2021 Aug 18;607(Pt 1):451-461. Epub 2021 Aug 18.

State Key Laboratory of Separation Membranes and Membrane Processes, School of Environmental Science and Engineering, Tiangong University, Tianjin 300387, China.

In this study, a functionalized CoO-BiO-Ti catalytic membrane (CBO-Ti-M) was prepared and applied for removing organic pollutants via activating peroxymonosulfate (PMS) in the dead-end filtration mode. Characterizations including scanning electron microcopy (SEM), X-ray diffraction (XRD) and X-ray photoelectron spectroscopy (XPS) showed that the CoO-BiO catalyst was successfully supported on the Ti membrane. The CBO-Ti-M /PMS system could efficiently remove various organic pollutants such as sulfamethoxazole, methyl orange, bisphenol A and methylene blue, achieving removal efficiencies of 98.0%-99.5%. The effects of PMS concentration, flow rate and solution environment on degradation efficiency were investigated in detail. Furthermore, quenching experiments, electron spin resonance (ESR) and in-situ open circuit potential (OCP) tests collectively demonstrated that singlet oxygen as well as the non-radical electron transfer pathway mainly contributed in the reaction mechanism. The synergistic effect of Co and Bi was illustrated according to XPS results, and the possible degradation pathway of MB was proposed based on LC-MS analysis. Reusability test showed that pollutant removal efficiency with the CBO-Ti-M /PMS system remained stable in four runs and limited metal leaching was observed.
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http://dx.doi.org/10.1016/j.jcis.2021.08.086DOI Listing
August 2021

[Effects of spraying desiccant on dehydration characteristics and grain quality of summer maize hybrids differing in maturity].

Ying Yong Sheng Tai Xue Bao 2020 Aug;31(8):2613-2620

College of Agronomy, Shandong Agricultural University/State Key Laboratory of Crop Biology, Tai'an 271018, Shandong, China.

Water content of summer maize hybrids grown in China is too high at harvesting stage, which limits the development of grain mechanical harvesting technology. Spraying the desiccant can regulate physiological process of crop grain filling and reduce water content at harvest. We explored the effects of spraying the desiccant on the dehydration process, grain moisture, and grain quality of summer maize hybrids differing in maturity. Spraying the desiccants reduced dry matter accumulation in different organs of maize, with strongest reduction of middle-late maturity hybrids. Dry matter transfer to the grains of the plants and the harvest index was improved, but with no changes of grain quality. The dehydration rate of grains was positively correlated with the rate of dehydration in diffe-rent organs. The dehydration rate of grains after spraying the desiccants was significantly positively correlated with the rate of dehydration of stems and sheaths. With no negative effects on yield, spraying the desiccant increased the total dehydration rate, shortened the time from flowering to physiological maturity, and increased the time from physiological maturity to harvest, which was beneficial to the further reduction of grain moisture in the later stage. The possibility of grain mechanical harvesting was increased. The economic benefits of spraying the desiccants on mechanical grain harvest of summer maize hybrids differing in maturity were not significantly different from those of ear mechanical harvesting. The economic benefits of middle-late maturity hybrids were higher than those of early maturity hybrids. Spraying desiccant may improve the possibility of grain mechanical harvesting.
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http://dx.doi.org/10.13287/j.1001-9332.202008.030DOI Listing
August 2020

FeO nanoplates anchored on TiCT MXene with enhanced pseudocapacitive and electrocatalytic properties.

Nanoscale 2021 Sep 8. Epub 2021 Sep 8.

School of Materials Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China.

TiCT, as novel members of the two-dimensional material family, hold great promise for electrochemical energy storage and catalysis, however, the electrochemical performance of TiCT is largely limited by the self-restacking of their layers due to van der Waals forces. In this study, we report a high-performance electrode material, TiCT supported FeO nanoplates (denoted as MXene-Fe), synthesized by a simple wet chemistry method in a solvothermal system. The mesoporous MXene-Fe material as a supercapacitor electrode exhibits a high specific capacitance of 368.0 F g at 1.0 A g and long cycling stability with about 81% capacitance retention after 10 000 cycles at 10.0 A g. Moreover, the optimized MXene-Fe also displays high electrocatalytic activity and stability toward the oxygen evolution reaction in alkaline solution (1.0 M KOH) with a low overpotential of 290 mV at 10 mA cm and a small Tafel slope of 65.1 mV dec. This work provides an effective strategy for developing novel TiCT-based functional materials with outstanding electrochemical performance for supercapacitors and electrocatalysis.
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http://dx.doi.org/10.1039/d1nr04383hDOI Listing
September 2021

Live-Cell Imaging of Guanosine Tetra- and Pentaphosphate (p)ppGpp with RNA-based Fluorescent Sensors.

Angew Chem Int Ed Engl 2021 Sep 6. Epub 2021 Sep 6.

University of Massachusetts Amherst, Biochemistry and Molecular Biology, UNITED STATES.

Guanosine tetra- and pentaphosphate, (p)ppGpp, are important alarmone nucleotides that regulate bacterial survival in stressful environment. A direct detection of (p)ppGpp in living cells is critical for our understanding of the mechanism of bacterial stringent response. However, it is still challenging to image cellular (p)ppGpp. Here, we report RNA-based fluorescent sensors for the live-cell imaging of (p)ppGpp. Our sensors are engineered by conjugating a recently identified (p)ppGpp-specific riboswitch with a fluorogenic RNA aptamer, Broccoli. These sensors can be genetically encoded and enable direct monitoring of cellular (p)ppGpp accumulation. Unprecedented information on cell-to-cell variation and cellular dynamics of (p)ppGpp levels is now obtained under different nutritional conditions. These RNA-based sensors can be broadly adapted to study bacterial stringent response.
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http://dx.doi.org/10.1002/anie.202111170DOI Listing
September 2021

A low dose cell therapy system for treating osteoarthritis: study and mechanistic investigations.

Bioact Mater 2022 Jan 2;7:478-490. Epub 2021 Jun 2.

Department of Sports Medicine and Adult Reconstruction Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, 201180, China.

Mesenchymal stem cells (MSCs) can be effective in alleviating the progression of osteoarthritis (OA). However, low MSC retention and survival at the injection site frequently require high doses of cells and/or repeated injections, which are not economically viable and create additional risks of complications. In this study, we produced MSC-laden microcarriers in spinner flask culture as cell delivery vehicles. These microcarriers containing a low initial dose of MSCs administered through a single injection in a rat anterior cruciate ligament (ACL) transection model of OA achieved similar reparative effects as repeated high doses of MSCs, as evaluated through imaging and histological analyses. Mechanistic investigations were conducted using a co-culture model involving human primary chondrocytes grown in monolayer, together with MSCs grown either within 3D constructs or as a monolayer. Co-culture supernatants subjected to secretome analysis showed significant decrease of inflammatory factors in the 3D group. RNA-seq of co-cultured MSCs and chondrocytes using Gene Ontology and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis revealed processes relating to early chondrogenesis and increased extracellular matrix interactions in MSCs of the 3D group, as well as phenotypic maintenance in the co-cultured chondrocytes. The cell delivery platform we investigated may be effective in reducing the cell dose and injection frequency required for therapeutic applications.
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http://dx.doi.org/10.1016/j.bioactmat.2021.05.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8379370PMC
January 2022

Is there a role for growth status in distinguishing gallbladder adenomas from cholesterol polyps? - A retrospective study based on 520 cholecystectomy patients.

Scand J Gastroenterol 2021 Aug 30:1-6. Epub 2021 Aug 30.

Gallbladder Disease Center, Tongji University Affiliated Shanghai East Hospital, Shanghai, China.

Introduction: Gallbladder adenomas have cancerous potential and occur in 4-8.9% of gallbladder polyps. The growth status (size progression and growth rate during follow-up) of polyps and their effectiveness for predicting adenomas are poorly defined. Herein, we compared adenomas and cholesterol polyps based on the growth status and evaluated the reported risk factors in predicting neoplasm.

Methods: We enrolled 520 patients who underwent preoperative ultrasonic follow-up more than 6 months with post-cholecystectomy pathologically confirmed gallbladder polyps. The patients were classified into adenoma and cholesterol polyp groups. Growth status, clinical characteristics, laboratory data, ultrasonic findings were reviewed and compared between the groups.

Results: Seventy-nine adenomas and 441 cholesterol polyps were analyzed. The mean diameter of adenomas (cholesterol polyps) was 7.24 ± 4.36 mm (6.23 ± 2.88 mm) in the initial and 12.06 ± 4.61 mm (10.05 ± 2.95 mm) in the preoperative examination. The median size progression (range) of polyps in the cholesterol polyps [3 (0, 22)] mm was smaller than that in adenomas [4 (0, 21)] mm ( = .075). The mean growth rate of adenomas (1.07 ± 1.33 mm/6 months) was slightly faster than in cholesterol polyps (0.83 ± 1.04 mm/6 months) ( = .338). The indicators significantly associated with adenomas were age >49.5 years, lack of gallbladder polyps/cholelithiasis family history, polyp size >11.5 mm and solitary polyp ( = .005, = .027,  = .001, and  = .021, respectively).

Conclusion: Growth status was not a valuable modality to distinguishing gallbladder adenomas from cholesterol polyps. Risk factors such as age, polyp size, and solitary polyp were effective in predicting adenomas.
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http://dx.doi.org/10.1080/00365521.2021.1970220DOI Listing
August 2021

Critical loads of headwater streams in China using SSWC model modified by comprehensive F-factor.

Sci Total Environ 2021 Aug 24;802:149780. Epub 2021 Aug 24.

State Key Laboratory of Environmental Simulation and Pollution Control, School of Environment, Tsinghua University, Beijing 100084, PR China; State Environmental Protection Key Laboratory of Sources and Control of Air Pollution Complex, Beijing 100084, PR China. Electronic address:

In order to evaluate the potential risk of surface water acidification in regions with historically-elevated acid deposition and to measure the recovery of such ecosystems after policy changes, critical loads and their exceedances were estimated for 349 headwater streams across China using a modified SSWC model. Such a model considered the acid-neutralizing capacity derived from high base cation deposition and the robust retention of sulfate and nitrate. Results indicated that China's streams had higher critical loads (averaged at 4.7 keq·ha·yr) and were less sensitive to acid deposition as compared to Europe and North America. The proportion of surveyed streams with acid deposition exceeded critical load decreased from 40.4% in 2005 to 29.5% in 2018, indicating a significant decrease in risk of surface water acidification, and thus a benefit from the emission abatement in recent years. Nonetheless, a relatively high risk of acidification still existed in southeast China with lower critical loads and most critical load exceedances. More efforts should be put into implementing emission control policies in the future.
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http://dx.doi.org/10.1016/j.scitotenv.2021.149780DOI Listing
August 2021

Efficacy and safety profile of avelumab monotherapy.

Crit Rev Oncol Hematol 2021 Aug 28;166:103464. Epub 2021 Aug 28.

The Second Affiliated Hospital & Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, 325027, China. Electronic address:

Avelumab can kill cancer cells through immune checkpoint inhibition and antibody-dependent cell-mediated cytotoxicity (ADCC). Here, we analyzed the clinical efficacy and adverse events (AEs) in 3935 cancer patients from 21 trials. Compared with conventional treatment, avelumab monotherapy was associated with more tumor responses and less AEs. The pooled objective response rate was 14.18 % (95 % CI, 10.68 %-18.08 %). More PD-L1 positive patients responded to avelumab monotherapy compared to PD-L1 negative patients. The overall incidence was 73.78 % for all-grade treatment-related AE (TRAE), 14.44 % for high-grade TRAE, 6.07 % for serious adverse event, 0.44 % for fatal adverse event, 17.86 % for all-grade immune-related AE (irAE), and 3.22 % for high-grade irAE. In summary, avelumab monotherapy presents an active anti-tumor activity, shows no sign of increased toxicity due to the ADCC. These characteristics provide rational for further application of avelumab in cancer treatment.
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http://dx.doi.org/10.1016/j.critrevonc.2021.103464DOI Listing
August 2021

Stability of varenicline concentration in saliva over twenty-one days at three storage temperatures.

Nicotine Tob Res 2021 Aug 30. Epub 2021 Aug 30.

Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada.

Introduction: Varenicline is the most efficacious drug for smoking cessation; saliva varenicline concentrations can be useful for the evaluation of adherence in smoking cessation trials. Saliva is a useful non-invasive matrix for mail-in specimen collection, if stable. We investigated the stability of varenicline in saliva at different storage temperatures simulating the time it takes to mail in a sample.

Methods: We evaluated the concentrations of varenicline, nicotine, cotinine, 3'-hydroxycotinine and 3'-hydroxycotinine/cotinine (3HC/COT) ratio in quality control saliva samples (and after repeated freezing and thawing), and in smokers' saliva samples, stored for up to 21 days at room temperature (~25°C), 4°C and -80°C.

Results: In saliva quality control samples, concentrations of varenicline, nicotine, cotinine, 3'-hydroxycotinine and 3HC/COT remained unchanged and showed little within-sample variation (CV≤5.5%) for up to 21 days at the three storage temperatures; they were also not altered after three thaw-freeze cycles. In smokers' saliva, a significant main effect of storage duration, but not temperature, was observed for varenicline, cotinine and 3'-hydroxycotinine, but not for nicotine or the 3HC/COT ratio. However, these changes were within analytical (i.e. equipment) variation resulting in little within-sample variation (CV≤5.8%) for all analytes in smokers saliva.

Conclusions: Varenicline, the other analytes and the 3HC/COT ratio remained stable in saliva during storage for 21 days at all temperatures tested and after repeated freezing and thawing with only minor changes in concentration over time. These findings support the potential use of mail-in approach for saliva samples in varenicline smoking cessation clinical trials.

Implications: Assessing saliva varenicline concentrations can be useful for the evaluation of adherence in smoking cessation trials. Saliva is a non-invasive matrix suitable for mail-in specimen collection. This is the first investigation of stability of varenicline in saliva. Varenicline, nicotine, cotinine, 3'-hydroxycotinine and 3HC/COT were stable in saliva for up to 21 days at room temperature (~25°C), 4°C and -80°C, supporting the use of a mail-in approach for saliva specimen in smoking cessation trials.
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http://dx.doi.org/10.1093/ntr/ntab173DOI Listing
August 2021

Aromatic Ketone-Catalyzed Photochemical Synthesis of Imidazo-isoquinolinone Derivatives.

J Org Chem 2021 Sep 26;86(18):12851-12861. Epub 2021 Aug 26.

Key Lab of Science and Technology of Eco-Textile, Ministry of Education, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, China.

We have developed an efficient photocatalytic decarboxylative radical addition/cyclization strategy to synthesize imidazo-isoquinolinone derivatives using inexpensive aromatic ketone photocatalysts. This method not only tolerates a wide range of functional groups but also works well for both alkyl and aryl radicals.
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http://dx.doi.org/10.1021/acs.joc.1c01486DOI Listing
September 2021

Indoor exposure levels of radon in dwellings, schools, and offices in China from 2000 to 2020: A systematic review.

Indoor Air 2021 Aug 25. Epub 2021 Aug 25.

School of Environment and Architecture, University of Shanghai for Science and Technology, Shanghai, China.

After decades of development, the indoor environment in China has changed. A systematic review was conducted from peer-reviewed scientific papers with field test data of indoor radon in China from 2000 to 2020 for three types of buildings. The mean concentrations of indoor radon for dwellings, school buildings, and office buildings are 54.6, 56.1, and 54.9 Bq/m . The indoor radon concentration was related to seasons, climate regions, ventilation, decoration, and other factors such as soil and outdoor air. Colder seasons, especially in severe colder areas of China, newer decorated buildings, closed windows, and doors were all associated with higher indoor radon concentrations. Variables like climate region and ventilation showed statistical significance in the correlation analysis. Regarding the increasing trend of indoor radon concentration in China during the last two decades, further study of indoor radon is necessary especially for school buildings and office buildings, and will help access its environmental burden of disease in China more accurately.
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http://dx.doi.org/10.1111/ina.12920DOI Listing
August 2021

Robust and high thermal-stable composite polymer electrolyte reinforced by PI nanofiber network.

Nanotechnology 2021 Sep 14;32(49). Epub 2021 Sep 14.

State Key Laboratory of Electrical Insulation and Power Equipment, School of Electrical Engineering, Xi'an Jiaotong University, Xi'an, Shanxi 710049, People's Republic of China.

To address the flammable and chemical unstable problems of liquid electrolyte, the solid electrolyte is a promising candidate to replace liquid electrolyte for solid-state batteries. Herein, a composite polymer electrolyte (CPE) of 3D polyimide (PI)-nanofiber membrane-incorporated polyethylene oxide (PEO)/lithium bis (triflu-romethanesulphonyl) imid (LiTFSI) is reported. Three advantages of the PI nanofiber network in the CPE include providing a continuous, rapid transport channel of lithium ions to improve the Li-ion conductivity, improving the mechanical properties and stability, and effectively inhibiting the dendrite growth of Li metal. The PI/PEO/LiTFSI CPE delivers an ionic conductivity of 4.2 × 10S cmat 60 °C, a wider electrochemical window to 5.4 V, and an excellent thermal stability, which result in the excellent electrochemical performance of LiFePOfull cells assembled with PI/PEO/LiTFSI CPE.
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http://dx.doi.org/10.1088/1361-6528/ac2093DOI Listing
September 2021

The Establishment and Spatiotemporal History of A Novel HIV-1 CRF01_AE Lineage in Shenyang City, Northeastern China in 2002-2019.

Virol Sin 2021 Aug 23. Epub 2021 Aug 23.

NHC Key Laboratory of AIDS Immunology (China Medical University), National Clinical Research Center for Laboratory Medicine, The First Affiliated Hospital of China Medical University, Shenyang, 110001, China.

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http://dx.doi.org/10.1007/s12250-021-00435-2DOI Listing
August 2021

A Novel Prognostic Model Based on Ferroptosis-Related Gene Signature for Bladder Cancer.

Front Oncol 2021 6;11:686044. Epub 2021 Aug 6.

Department of Urology, The Third Affiliated Hospital of Kunming Medical University, Kunming, China.

Background: Bladder cancer (BC) is a molecular heterogeneous malignant tumor; the treatment strategies for advanced-stage patients were limited. Therefore, it is vital for improving the clinical outcome of BC patients to identify key biomarkers affecting prognosis. Ferroptosis is a newly discovered programmed cell death and plays a crucial role in the occurrence and progression of tumors. Ferroptosis-related genes (FRGs) can be promising candidate biomarkers in BC. The objective of our study was to construct a prognostic model to improve the prognosis prediction of BC.

Methods: The mRNA expression profiles and corresponding clinical data of bladder urothelial carcinoma (BLCA) patients were downloaded from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. FRGs were identified by downloading data from FerrDb. Differential analysis was performed to identify differentially expressed genes (DEGs) related to ferroptosis. Univariate and multivariate Cox regression analyses were conducted to establish a prognostic model in the TCGA cohort. BLCA patients from the GEO cohort were used for validation. Gene ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), and single-sample gene set enrichment analysis (ssGSEA) were used to explore underlying mechanisms.

Results: Nine genes (, and ) were identified to construct a prognostic model. Patients were classified into high-risk and low-risk groups according to the signature-based risk score. Receiver operating characteristic (ROC) and Kaplan-Meier (K-M) survival analysis confirmed the superior predictive performance of the novel survival model based on the nine-FRG signature. Multivariate Cox regression analyses showed that risk score was an independent risk factor associated with overall survival (OS). GO and KEGG enrichment analysis indicated that apart from ferroptosis-related pathways, immune-related pathways were significantly enriched. ssGSEA analysis indicated that the immune status was different between the two risk groups.

Conclusion: The results of our study indicated that a novel prognostic model based on the nine-FRG signature can be used for prognostic prediction in BC patients. FRGs are potential prognostic biomarkers and therapeutic targets.
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http://dx.doi.org/10.3389/fonc.2021.686044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8378228PMC
August 2021

Effects of Urea-Ammonium Nitrate Solution on Yield, NO Emission, and Nitrogen Efficiency of Summer Maize Under Integration of Water and Fertilizer.

Front Plant Sci 2021 3;12:700331. Epub 2021 Aug 3.

State Key Laboratory of Crop Biology and College of Agronomy, Shandong Agricultural University, Tai'an, China.

In order to clarify the effects of urea-ammonium nitrate solution (UAN) on the yield, nitrogen-use efficiency (NUE), and NO emissions of summer maize under the condition of water and fertilizer integration, different types of nitrogen fertilizer were selected, namely, ordinary urea (urea) and UAN. Our results showed that the application of UAN was beneficial to improve the dry matter accumulation and the distribution of summer maize. Compared with urea treatment, the total nitrogen accumulation of UAN treatment was increased by 15.8%, and the harvest index was increased by 5.5%. The partial productivity, agronomic use efficiency, and recovery rate of nitrogen for UAN treatment were also increased by 9.1, 19.8, and 31.2%, respectively, compared to those of urea treatment. The soil nitrogen dependence rate treated with UAN was significantly decreased by 13.6%, compared to that of urea treatment. In addition, UAN was beneficial to reduce NO emissions. The NO warming potential (GWP) and NO greenhouse gas intensity (GHGI) of urea treatment were 39.3 and 52.4% higher, compared to those of UAN treatment. The improvement of dry matter accumulation and distribution and nitrogen efficiency for UAN treatment were beneficial to increase the grain yield by 9.1%, compared to that of urea treatment. In conclusion, under the fertigation, the application of UAN favors higher yield and nitrogen uptake, with less soil nitrogen residue, higher NUE, and better environmental effect.
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http://dx.doi.org/10.3389/fpls.2021.700331DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8369924PMC
August 2021

Effect of Conductivity on In Situ Deactivation of Catechol-Boronate Complexation-Based Reversible Smart Adhesive.

Biomacromolecules 2021 Sep 19;22(9):4004-4015. Epub 2021 Aug 19.

Department of Biomedical Engineering, Michigan Technological University, Houghton, Michigan 49931, United States.

To reduce the need for elevated electrical potential to deactivate catechol-based smart adhesive and preserve its reversibility, conductive 1-pyrenemethyl methacrylate (PyMA) was incorporated into a catechol and phenylboronic acid-containing adhesive coating immobilized on aluminum (Al) discs. Electrochemical impedance spectroscopy (EIS) indicated that incorporation of 26 mol % of PyMA reduced ionic resistance () and charge-transfer resistance () of the coating from over 22 Ω/mm to 5.9 and 1.2 Ω/mm, respectively. A custom-built Johnson-Kendall-Roberts (JKR) contact mechanics test setup was used to evaluate the adhesive property of the coating with in situ applied electricity using a titanium (Ti) sphere both as a test substrate as well as the cathode for application of electricity and the Al disc as the anode. The adhesive coating demonstrated over 95% reduction in the adhesive property when electricity (1-2 V) was applied while the adhesive was in direct contact with the Ti surface. The addition of PyMA enables the deactivation of the adhesive using a voltage as low as 1 V. Both cyclic voltammetry (CV) and attenuated total reflection-Fourier transform infrared (ATR-FTIR) spectra confirmed the formation of catechol-boronate complexation through electrochemical stimulation. Breaking the complex with an acidic buffer (pH 3) recovered the catechol for strong wet adhesion and the coating could be repeatedly deactivated and reactivated using low electrical potential for up to five cycles. Incorporation of both conductive PyMA and boronic acid as the temporary protecting group was required to achieve rapidly switchable adhesive that could be deactivated with low applied voltage.
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http://dx.doi.org/10.1021/acs.biomac.1c00802DOI Listing
September 2021

Mononucleosis-like illnesses due to co-infection with severe fever with thrombocytopenia syndrome virus and spotted fever group rickettsia:a case report.

BMC Infect Dis 2021 Aug 18;21(1):829. Epub 2021 Aug 18.

Department of Infectious Diseases, The First Affiliated Hospital of China Medical University, No. 155 Nanjing North Street, Shenyang, 110001, Liaoning Province, China.

Background: We report a mononucleosis-like illnesses case due to co-infection with severe fever with thrombocytopenia syndrome virus (SFTSV) and spotted fever group rickettsia (SFGR), which to the best of our knowledge, has never been reported .

Case Presentation: A 64-year-old male with an 11-day history of fever, sore throat, malaise, nausea, and non-pruritic rash was admitted to our emergency department. Prior to admission, he was bitten by ticks. Laboratory tests revealed a white blood cell count of 24,460 cells/μL with 25% atypical lymphocytes and 20% mononucleosis, thrombocytopenia. Test results were positive for SFTSV RNA, SFTSV-specific IgM antibody, and SFGR-specific IgM antibody. He was diagnosed with mononucleosis-like illnesses due to co-infection with SFTSV and SFGR. After administration of doxycycline, he recovered completely.

Conclusions: The clinical presentation may be atypical in co-infection with SFTSV and SFGR. This finding highlighted the importance of considering SFGR infection, as well as a SFSTV and SFGR co-infection for the differential diagnosis of patients bitten by ticks in SFTSV-endemic areas.
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http://dx.doi.org/10.1186/s12879-021-06434-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8371423PMC
August 2021

A Facile Strategy for Constructing a Carbon-Particle-Modified Metal-Organic Framework for Enhancing the Efficiency of CO Electroreduction into Formate.

Angew Chem Int Ed Engl 2021 Aug 18. Epub 2021 Aug 18.

Department of Chemistry, Key Laboratory of Advanced Energy Material Chemistry, (Ministry of Education), Renewable Energy Conversion and Storage Center, Nankai University, Tianjin, 300071, China.

Electrocatalytic reduction of CO by metal-organic frameworks (MOFs) has been widely investigated, but insufficient conductivity limits application. Herein, a porous 3D In-MOF {(Me NH )[In(BCP)]⋅2 DMF} (V11) with good stability was constructed with two types of channels (1.6 and 1.2 nm diameter). V11 exhibits moderate catalytic activity in CO electroreduction with 76.0 % of Faradaic efficiency for formate (FE ). Methylene blue molecules of suitable size and pyrolysis temperature were introduced and transformed into carbon particles (CPs) after calcination. The performance of the obtained [email protected] is significantly improved both in FE (from 76.0 % to 90.1 %) and current density (2.2 times). Control experiments show that introduced CPs serve as accelerant to promote the charges and mass transfer in framework, and benefit to sufficiently expose active sites. This strategy can also work on other In-MOFs, demonstrating the universality of this method for electroreduction of CO .
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http://dx.doi.org/10.1002/anie.202110387DOI Listing
August 2021

Exosomes Derived From Adipose-Derived Mesenchymal Stem Cells Ameliorate Radiation-Induced Brain Injury by Activating the SIRT1 Pathway.

Front Cell Dev Biol 2021 29;9:693782. Epub 2021 Jul 29.

Department of Burns and Cutaneous Surgery, Xijing Hospital, Air Force Military Medical University, Xi'an, China.

Objective: Studies have shown that the therapeutic effects of mesenchymal stem cells (MSCs) are mediated in a paracrine manner, mainly through extracellular vesicles such as exosomes. Here, we designed a study to investigate whether exosomes derived from adipose-derived mesenchymal stem cells (ADMSC-Exos) had protective effects in a rat model of radiation-induced brain injury and in microglia.

Methods: Male adult Sprague-Dawley (SD) rats were randomly divided into three groups: the control group, the radiation group (30 Gy), and the radiation + exosomes group (30 Gy + 100 ug exosomes). Meanwhile, microglia were divided into four groups: the control group, the radiation group (10 Gy), the radiation + exosomes group (10 Gy + 4 ug exosomes), and radiation + exosomes + EX527 group (10 Gy + 4 ug exosomes + 100 nM EX527). Tissue samples and the levels of oxidative stress and inflammatory factors in each group were compared.

Results: Statistical analysis showed that after irradiation, ADMSC-Exos intervention significantly reduced the levels of caspase-3, malondialdehyde (MDA), 8-hydroxydeoxyguanosine (8-OHdG), tumor necrosis factor-α (TNF-α), interleukin-4 (IL-4), and promoted the recovery of superoxide dismutase (SOD), catalase (CAT), IL-4, and IL-10. Moreover, ADMSC-Exos intervention inhibited microglial infiltration and promoted the expression of SIRT1. Furthermore, the results showed that the above effects of ADMSC-Exos could be reversed by SIRT-1 inhibitor EX527.

Conclusion: This study demonstrated that ADMSC-Exos exerted protective effects against radiation-induced brain injury by reducing oxidative stress, inflammation and microglial infiltration via activating the SIRT1 pathway. ADMSC-Exos may serve as a promising therapeutic tool for radiation-induced brain injury.
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http://dx.doi.org/10.3389/fcell.2021.693782DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8358610PMC
July 2021

Responses of nitrogen efficiency and antioxidant system of summer maize to waterlogging stress under different tillage.

PeerJ 2021 26;9:e11834. Epub 2021 Jul 26.

Shandong Agricultural University, Taian, China.

Waterlogging was one of the main abiotic stresses affecting maize yield and growth in the North China Plain, while ridge tillage effectually improved soil environment, enhanced crop stress resistance to waterlogging, and increased grain yield of waterlogged maize. In order to explore the responses of nitrogen (N) efficiency and antioxidant system of summer maize to waterlogging stress under different tillage, a field experiment was conducted to explore N use efficiency, leaf activities of superoxide dismutase (SOD), peroxidase (POD), and catalase (CAT), and malondialdehyde (MDA) content of waterlogged maize Denghai 605 (DH605) and Zhengdan 958 (ZD958) under different tillage system (ridge planting and flat planting). Our results showed that ridge tillage was beneficial to ameliorate waterlogging damages on antioxidant system by increasing SOD, POD, and CAT activities, and decreasing MDA content. Moreover, ridge tillage significantly increased N efficiency of waterlogged maize. N translocation amount (NTA), N translocation efficiency (NTE), N contribution proportion (NCP), N harvest index (NHI), and N use efficiency (NUE) of waterlogging treatment under ridge planting system (W-V3+R) for DH605 was increased by 108%, 69%, 60%, 8% and 16%, while ZD958 increased by 248%, 132%, 146%, 13% and 16%, respectively, compared to those of waterlogging treatment under flat planting system (W-V3). Ultimately, ridge tillage led to a significant yield improvement by 39% and 50% for DH605 and ZD958, respectively, compared to that of W-V3. In conclusion, ridge tillage was conducive to retard leaf aging, and enhance nitrogen efficiency, thereby resulting in a yield improvement of waterlogged summer maize.
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http://dx.doi.org/10.7717/peerj.11834DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8320525PMC
July 2021

Prognostic and diagnostic roles of prolyl 4-hydroxylase subunit α members in breast cancer.

Biomark Med 2021 Sep 13;15(13):1085-1095. Epub 2021 Aug 13.

Department of Clinical Laboratory, Xiang'an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, 361102, China.

We aimed to evaluate the diagnostic and prognostic values of in breast cancer (BC) patients. Kaplan-Meier plotter was used to evaluate the prognostic values of  and correlations between their expression and clinical characteristics were assessed based on The Cancer Genome Atlas and the Human Protein Atlas. The current study showed that P4HAs were highly expressed in BC patients with clinical stage I compared with nontumor control and elevated were correlated with poor survival outcomes. Subtypes analysis revealed that and were most expressed in HER2+ subtypes patients. Univariate analysis displayed that elevated and correlated with unfavorable recurrence-free survival in mutated patients. This study indicated the diagnostic and prognostic roles of members and broadened the biomarker fields of early diagnosis and prognostic monitoring of BC patients.
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http://dx.doi.org/10.2217/bmm-2020-0323DOI Listing
September 2021

Limitations in activities of daily living increase the risk of stroke in older Chinese adults: a population-based longitudinal study.

Neural Regen Res 2022 Mar;17(3):643-648

Department of Neurology, Guangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Institute of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong Province, China.

It remains unclear whether limitations in activities of daily living (ADL) increase the risk of stroke in older Chinese adults. This longitudinal study used data from the Chinese Longitudinal Healthy Longevity Survey to investigate the effects of limitations in ADL on the incidence of stroke in older adults. Between 2002 and 2011, 46,728 participants from 22 provinces in China were included in this study. Of participants, 11,241 developed limitations in ADL at baseline. A 3-year follow-up was performed to determine the incidence of stroke. During the 3-year follow-up, 929 participants (8.26%) and 2434 participants (6.86%) experienced stroke in the ADL limitations group and non-ADL limitations group, respectively. Logistic regression was used to analyze the effect of ADL limitations on the risk of stroke. The results showed that after adjusting for the confounding factors gender, age, weight, hypertension, diabetes, heart disease, natural teeth, hearing impairment, visual impairment, smoking, alcohol abuse, exercise, ethnicity, literacy, residential area, and poverty, the ADL limitations group had a 77% higher risk of developing stroke than the non-ADL limitations group. After propensity score matching, the ADL limitations group still had a 33% higher risk of developing stroke than the non-ADL limitations group (OR = 1.326, 95% CI: 1.174-1.497). These findings suggest that limitations in ADL are a stroke risk factor.
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http://dx.doi.org/10.4103/1673-5374.320994DOI Listing
March 2022
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