Publications by authors named "Bin Yang"

2,390 Publications

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Properdin Deficiency Impairs Phagocytosis and Enhances Injury at Kidney Repair Phase Post Ischemia-Reperfusion.

Front Immunol 2021 6;12:697760. Epub 2021 Sep 6.

Department of Cardiovascular Sciences, College of Life Sciences, University of Leicester, University Hospitals of Leicester NHS Trust, Leicester, United Kingdom.

Properdin, a positive regulator of complement alternative pathway, participates in renal ischemia-reperfusion (IR) injury and also acts as a pattern-recognition molecule affecting apoptotic T-cell clearance. However, the role of properdin in tubular epithelial cells (TECs) at the repair phase post IR injury is not well defined. This study revealed that properdin knockout (P) mice exhibited greater injury in renal function and histology than wild-type (WT) mice post 72-h IR, with more apoptotic cells and macrophages in tubular lumina, increased active caspase-3 and HMGB1, but better histological structure at 24 h. Raised erythropoietin receptor by IR was furthered by P and positively correlated with injury and repair markers. Properdin in WT kidneys was also upregulated by IR, while HO-increased properdin in TECs was reduced by its small-interfering RNA (siRNA), with raised HMGB1 and apoptosis. Moreover, the phagocytic ability of WT TECs, analyzed by pHrodo bioparticles, was promoted by HO but inhibited by P. These results were confirmed by counting phagocytosed HO-induced apoptotic TECs by end labeling fragmented DNAs but not affected by additional serum with/without properdin. Taken together, P results in impaired phagocytosis at the repair phase post renal IR injury. Properdin locally produced by TECs plays crucial roles in optimizing damaged cells and regulating phagocytic ability of TECs to effectively clear apoptotic cells and reduce inflammation.
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http://dx.doi.org/10.3389/fimmu.2021.697760DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8450566PMC
September 2021

Pharmacokinetic Properties of S-oxiracetam After Single and Multiple Intravenous Infusions in Healthy Volunteers.

Eur J Drug Metab Pharmacokinet 2021 Sep 21. Epub 2021 Sep 21.

Anhui Provincial Center for Drug Clinical Evaluation, Yijishan Hospital of Wannan Medical College, Wuhu, 241001, Anhui Province, China.

Background And Objectives: As a chiral drug, oxiracetam (ORT) can exist in two different isomeric forms: S-oxiracetam (S-ORT) and R-oxiracetam (R-ORT). S-ORT has emerged as a promising nootropic drug with the potential to treat brain injury and the resulting loss of neural function, memory and mental impairment as assessed by studies in various animal models. However, limited data are available on the pharmacokinetics of S-ORT in humans, so the present study was designed to evaluate the safety and pharmacokinetic profile of S-ORT in healthy volunteers.

Methods: In part 1, subjects were intravenously administered single ascending dose (2.0, 4.0 and 8.0 g) S-ORT. In part 2, subjects were treated at a single intravenous infusion dose of 3.0 g S-ORT or 6.0 g racemic ORT using a two-sequence, two-period crossover design. In part 3, subjects were intravenously injected with 4.0 g S-ORT once a day for 7 days. Blood and urine samples were collected to evaluate the pharmacokinetic parameters and urine excretion rate. The safety profile of the drug was also evaluated throughout the study.

Results: Fifty-two subjects (30 in part 1, 12 in part 2, 10 in part 3) completed the study; only one subject displayed a mild adverse event, which possibly was treatment related, and no serious adverse event occurred. In part 1 for a single dose of 2.0, 4.0 and 8.0 g, the maximum concentration (C) values were 111.28 ± 18.99, 230.76 ± 29.16 and 352.67 ± 42.94 μg/ml, respectively; the values of area under the plasma concentration-time curve (AUC) from time zero to the time of last quantifiable concentration (AUC) were 267.09 ± 59.66, 524.50  ± 72.87 and 822.68 ± 95.21 μg·h/ml, respectively; the AUC from 0 h to infinity (AUC) values were 274.72 ± 61.65, 536.06 ± 78.13 and 832.07 ± 96.91 μg·h/ml, respectively. The urine excretion rate of the unchanged drug was approximately 60%. After consecutive administration of S-ORT for 7 days, the accumulation index was 1.05 ± 0.08. The plasma drug concentration-time curves for both S-ORT and R-oxiracetam (R-ORT) were almost identical.

Conclusions: S-ORT was well tolerated, and no serious adverse events occurred in 2.0, 4.0 and 8.0 g in single- and 4.0 g in multiple-dose studies. S-ORT showed dose linearity with increasing doses and no drug accumulation after 7 days of continuous administration was observed.
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http://dx.doi.org/10.1007/s13318-021-00718-9DOI Listing
September 2021

Reverse engineering gene regulatory network based on complex-valued ordinary differential equation model.

BMC Bioinformatics 2021 Sep 20;22(Suppl 3):448. Epub 2021 Sep 20.

School of Information Science and Engineering, Zaozhuang University, Zaozhuang, 277160, China.

Background: The growing researches of molecular biology reveal that complex life phenomena have the ability to demonstrating various types of interactions in the level of genomics. To establish the interactions between genes or proteins and understand the intrinsic mechanisms of biological systems have become an urgent need and study hotspot.

Results: In order to forecast gene expression data and identify more accurate gene regulatory network, complex-valued version of ordinary differential equation (CVODE) is proposed in this paper. In order to optimize CVODE model, a complex-valued hybrid evolutionary method based on Grammar-guided genetic programming and complex-valued firefly algorithm is presented.

Conclusions: When tested on three real gene expression datasets from E. coli and Human Cell, the experiment results suggest that CVODE model could improve 20-50% prediction accuracy of gene expression data, which could also infer more true-positive regulatory relationships and less false-positive regulations than ordinary differential equation.
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http://dx.doi.org/10.1186/s12859-021-04367-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8451084PMC
September 2021

A glyoxylate-containing benzene derivative and butenolides from a marine algicolous fungus sp. SCSIO 41304.

Nat Prod Res 2021 Sep 20:1-8. Epub 2021 Sep 20.

School of Pharmaceutical Sciences, Changchun University of Chinese Medicine, Changchun, China.

A new glyoxylate-containing benzene derivative, methyl 2-(4-hydroxy-3-(3'-methyl-2'-butenyl)phenyl)-2-oxoacetate (), together with ten known compounds (-), were isolated from the marine algicolous fungus, sp. SCSIO 41304. Their planar structures and absolute configurations were elucidated by detailed NMR, MS spectroscopic analysis and comparing with literature data. Compound was isolated as a new fungal secondary metabolite, possessing a methyl glyoxylate moiety R-CO-CO-OCH, which is rare in natural sources. All the isolated compounds (-) were tested for their antibacterial and enzyme inhibitory activities against acetylcholinesterase (AChE) and pancreatic lipase (PL). Among these compounds, aspulvinone H () showed moderate inhibition against AChE and PL with IC values of 25.95 and 47.06 M, respectively. Further molecular docking simulation exhibited that compound could well bind to the catalytic pockets of the AChE and PL.
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http://dx.doi.org/10.1080/14786419.2021.1978994DOI Listing
September 2021

Improved analytical model for the relaxation process of aeolian sand transport.

Eur Phys J E Soft Matter 2021 Sep 18;44(9):116. Epub 2021 Sep 18.

School of Energy and Power Engineering, Xi'an Jiaotong University, Xi'an, China.

The process from the initial sand movement to sand flux saturation is described as the relaxation of aeolian sand transport. For this relaxation process, most existing models distinguish the conditions with and without upwind sand flux, therefore lacking in generality. An improved analytical model is proposed in this paper, which incorporates the phenomena of "overshoot" and "equilibrium" and the concept of the region of initiation by fluid, and is able to unify the cases with and without upwind sand flux. Within the proposed model, a new definition of the saturation length is proposed based on the analogy between two damping oscillation models, and its constancy is physically interpreted and verified with wind tunnel experimental data. In comparison with the existing models, the proposed model agrees better with the measurements of the process of sand transport, thereby shedding light on the understanding of aeolian sand transport under complex circumstances.
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http://dx.doi.org/10.1140/epje/s10189-021-00125-7DOI Listing
September 2021

Therapeutic effect of Moringa oleifera leaves on constipation mice based on pharmacodynamics and serum metabonomics.

J Ethnopharmacol 2021 Sep 14;282:114644. Epub 2021 Sep 14.

National Resource Center for Chinese Materia Medica, State Key Laboratory Breeding Base of Daodi Herbs, China Academy of Chinese Medical Sciences, Beijing, 100700, China. Electronic address:

Ethnopharmacological Relevance: Moringa oleifera is native to India, and has been introduced to China in recent years. Moringa oleifera leaves (MOL), as Ayurvedic medicine, has efficacy of Pachana karma (digestive) and Virechana karma (purgative). Folium Sennae (FS), Rhubarb (RB), Aloe vera (AV), Hemp seed (HS) are commonly used as laxatives in Traditional Chinese Medicine (TCM), which have different characteristics. However, the intensity of the diarrheal effect of MOL and its mechanism of action are unclear.

Aim Of The Study: The methods of pharmacology and omics were used to compare the purgative effects of MOL and FS, RB, AV, HS, and their effects on metabolomics, to analyze the purgative characteristics and related mechanisms of MOL.

Materials And Methods: C57BL/6J mouse model of constipation was established by feeding low-fiber food. Feces parameters and colon pathology were used to evaluate the effect of FS, RB, AV, HS and MOL. And mass spectrometry-based serum metabolomics was performed. The differential metabolites of these herbs in the treatment of constipation were obtained by OPLS-DA analysis. Furthermore, pathway analysis was conducted based on different metabolites.

Results: Moringa leaves can adjust the stool number, wet fecal weight and fecal water content to varying degrees to achieve laxative effects, and recover colon muscle thickness and mucus. Analysis of metabolomics results showed that 71 metabolites from LC-MS datasets between model group and control group were obtained. 29, 12, 44, 29 and 20 metabolites were significantly reversed by FS, RB, AV, HS, MOL compared with model group respectively. According to the metabolic pathways, RB and AV may be clustered into a similar category, and MOL, FS and HS showed similarity of metabolic characteristics.

Conclusion: The purgative effect of MOL is inferior to that of FS, and stronger than that of AV, RB and HS. The metabolic pathway for constipation is more similar to that of FS. MOL has a long-lasting and mild effect of laxative, increasing defecation volume and water content of feces, and may become a fewer side effects medicine to treat constipation.
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http://dx.doi.org/10.1016/j.jep.2021.114644DOI Listing
September 2021

Evaluation of gastric emptying in patients with gastroparesis by three-dimensional ultrasound.

Ann Transl Med 2021 Aug;9(16):1343

Department of Ultrasound, Jinling Hospital, Nanjing Medical University, Nanjing, China.

Background: To diagnose gastroparesis, it is necessary to assess gastric emptying accurately. This study aims to investigate the role of three-dimensional ultrasonography (3-D US) on the measurement of gastric volume to evaluate gastric accommodation in healthy patients.

Methods: In this study, 21 volunteers, 46 patients with diabetic gastroparesis (DG), and 22 patients with postsurgical gastroparesis (PSG) underwent 3-D US after oral administration of 250 mL gastrointestinal contrast at 2, 30, 60, and 90 min. The volume of the contrast agent in the stomach was then calculated using the virtual organ computer-aided analysis (VOCAL) (Virtual Organ Computer-aided AnaLysis, General Electric Medical Systems, Kretztechnik, Zipf, Austria).

Results: In the DG group, the gastric residue volumes at postprandial 60 and 90 min were significantly higher than those in the healthy group (P<0.05), and the areas under the receiver operating characteristic (ROC) curve of these parameters were 0.830 and 0.957, respectively. There were significant differences between the PSG and healthy groups at 60 and 90 min; however, the AUC of gastric residue at 90 min (0.955) was higher than the AUC at 60 min (0.697).

Conclusions: Therefore, this study showed that the 3-D US is a powerful tool for assessing gastric emptying and provides a new strategy for diagnosing gastroparesis.
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http://dx.doi.org/10.21037/atm-21-3972DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8422084PMC
August 2021

MR guided radiation therapy of patients with cardiovascular implantable electronic device on a 1.5 T MR-Linac.

Pract Radiat Oncol 2021 Sep 11. Epub 2021 Sep 11.

Medical Physics and Research Department, Hong Kong Sanatorium & Hospital, 2 Village Road, Happy Valley, Hong Kong.

Magnetic resonance imaging guided radiation therapy (MRgRT) is reported for treating patients with an insertable cardiac monitor (ICM) and implantable cardiac pacemakers (ICP). All treatments were delivered using a 1.5 T MR-Linac. Among the four patients, two were treated with stereotactic body radiation therapy (SBRT) at a dose of 40 Gy in 5 fractions. A clinical safety protocol was developed to address the decision-making and patient selection, as well as the clarified responsibilities of different parties for management of patients with cardiovascular implantable electronic devices (CIEDs). Dose estimation based on out-of-field dose data is necessary for CIED located outside the treatment fields.
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http://dx.doi.org/10.1016/j.prro.2021.08.011DOI Listing
September 2021

Azaphilones and meroterpenoids from the soft coral-derived fungus Penicillium glabrum glmu003.

Chem Biodivers 2021 Sep 14. Epub 2021 Sep 14.

South China Sea Institute of Oceanology Chinese Academy of Sciences, CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, Xingang Road, 510301, Guangzhou, CHINA.

Two new azaphilone compounds, daldinins G ( 1 ) and H ( 2 ), together with nine known compounds daldinin D ( 3 ), sargassopenilline B ( 4 ), austalide V ( 5 ), austalide K ( 6 ), austalide P ( 7 ), austalide P acid ( 8 ), austalide H ( 9 ), 13-O-deacetyaustalide I ( 10 ), and 17-O-demethylaustalide B ( 11 ), were isolated from the soft coral-derived fungus Penicillium glabrum glmu003. The new structures of 1 , and 2 were elucidated on the basis of 1D and 2D NMR, mass spectra, and electronic circular dichroism (ECD) data analysis. The compound 5 showed moderate inhibitory activity against pancreatic lipase (PL) with IC 50 values of 23.9 μ g/ml.
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http://dx.doi.org/10.1002/cbdv.202100663DOI Listing
September 2021

CTRP6(C1q/Tumor Necrosis Factor (TNF)-related protein-6) alleviated the sevoflurane induced injury of mice central nervous system by promoting the expression of p-Akt (phosphorylated Akt).

Authors:
Zhiwen Liu Bin Yang

Bioengineered 2021 12;12(1):5716-5726

Department of Anesthesiology, The Second Hospital, University to South China Hengyang Cty, Hengyang City, Hunan Province, China.

Postoperative cognitive impairment and nervous system damage caused by anesthetics seriously affect patient's postoperative recovery. Recent study has revealed that CTRP6 could alleviate apoptosis, inflammation and oxidative stress of nerve cells, thereby relieving nervous system damage induced by cerebral ischemia reperfusion. However, whether CTRP6 could relieve sevoflurane induced central nervous system injury is unclear. We stimulated C57BL/6 mice with sevoflurane and injected CTRP6 overexpression adenovirus vector. Next, H&E staining and TUNEL assays were performed to examine the effect of CTRP6 on sevoflurane induced injury of central nervous system. Finally, we isolated primary nerve cells of hippocampus. Flow cytometry and commercial kits were used for the detection of apoptosis and ROS levels of these cells. Western blotting was used for the detection of the expression level of p-Akt in central nervous tissues and primary cells. Results showed that sevoflurane induced injury and apoptosis of central nervous tissues. Overexpression of CTRP6 relieved apoptosis and injury of these tissues. CTRP6 inhibited the expression of cleaved caspase-3 and cleaved PARP in these tissues. Sevoflurane promoted apoptosis of primary cells and enhanced the expression of ROS and MDA in these cells. Overexpression of CTRP6 alleviated apoptosis and suppressed production of ROS and MDA in these cells. In addition, CTRP6 also enhanced the expression of p-Akt in primary cells. Taken together, our results suggested that CTRP6 relieved sevoflurane induced injury of central nervous tissues by promoting the expression of p-Akt. Therefore, the targeted drug of CTRP6 should be explored for the remission of these symptoms.
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http://dx.doi.org/10.1080/21655979.2021.1967838DOI Listing
December 2021

Diagnosis of Primary Cutaneous Amyloidosis by Rapid 4,6-Diamidino-2-Phenylindole Staining.

Dermatology 2021 Aug 26:1-9. Epub 2021 Aug 26.

Department of Dermatology, Dermatology Hospital, Southern Medical University, Guangzhou, China.

Background: Quick and accurate diagnosis of primary cutaneous amyloidosis (PCA) may be difficult because its symptoms are often subtle and nonspecific.

Objective: We sought to review the literature on the roles of various staining methods in the diagnosis of amyloidosis and demonstrate added benefits of using rapid 4,6-diamidino-2-phenylindole (DAPI) staining in the diagnosis of PCA.

Methods: Three groups of cases, namely, PCA, neurodermatitis, and prurigo nodularis, were retrieved from a computerized pathology database for study, and their paraffin-embedded tissue blocks were cut following standard procedures. The tissue sections were stained with three stains: hematoxylin-eosin (HE), Congo red, and DAPI stains, and examined under the microscope to compare the staining patterns of these three methods. We also performed amyloid keratin and apolipoprotein E (APOE) staining on the sections of PCA in order to further support our conclusion. The PCA sections were read by junior and senior dermatopathologists for comparison.

Results: The sensitivity of DAPI staining for PCA was significantly higher than that of Congo red staining and HE staining (p < 0.001). This statement holds true whether the experiment was grouped in one sample or was divided into groups of junior and senior dermatopathologists (p < 0.001). The DAPI-positive staining areas, except for the nuclei, were consistent with the amyloid deposition areas. In this study, DAPI staining had a sensitivity of 98.6% and a specificity of 100%.

Conclusion: DAPI staining could serve as a useful technique to establish the diagnosis of PCA, and its high efficacy in diagnosing PCA makes it less dependent on the experience levels of the evaluators. Additionally, the binding of DAPI to the A-T-rich sequence of double-stranded DNA suggests that amyloid may contain DNA or a similarly structured nucleic acid.
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http://dx.doi.org/10.1159/000518082DOI Listing
August 2021

Contralateral Axon Sprouting but Not Ipsilateral Regeneration Is Responsible for Spontaneous Locomotor Recovery Post Spinal Cord Hemisection.

Front Cell Neurosci 2021 26;15:730348. Epub 2021 Aug 26.

State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China.

Spinal cord injury (SCI) usually results in permanent functional impairment and is considered a worldwide medical problem. However, both motor and sensory functions can spontaneously recover to varying extents in humans and animals with incomplete SCI. This study observed a significant spontaneous hindlimb locomotor recovery in Sprague-Dawley rats at four weeks after post-right-side spinal cord hemisection at thoracic 8 (T8). To verify whether the above spontaneous recovery derives from the ipsilateral axonal or neuronal regeneration to reconnect the lesion site, we resected either the scar tissue or right side T7 spinal cord at five weeks post-T8 hemisected injury. The results showed that the spontaneously achieved right hindlimb locomotor function had little change after resection. Furthermore, when T7 left hemisection was performed five weeks after the initial injury, the spontaneously achieved right hindlimb locomotor function was dramatically abolished. A similar result could also be observed when T7 transection was performed after the initial hemisection. The results indicated that it might be the contralateral axonal remolding rather than the ipsilateral axonal or neuronal regeneration beyond the lesion site responsible for the spontaneous hindlimb locomotor recovery. The immunostaining analyses and corticospinal tracts (CSTs) tracing results confirmed this hypothesis. We detected no substantial neuronal and CST regeneration throughout the lesion site; however, significantly more CST fibers were observed to sprout from the contralateral side at the lumbar 4 (L4) spinal cord in the hemisection model rats than in intact ones. In conclusion, this study verified that contralateral CST sprouting, but not ipsilateral CST or neuronal regeneration, is primarily responsible for the spontaneous locomotor recovery in hemisection SCI rats.
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http://dx.doi.org/10.3389/fncel.2021.730348DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8426601PMC
August 2021

Trends and age-period-cohort effects on mortality of the three major gynecologic cancers in China from 1990 to 2019: Cervical, ovarian and uterine cancer.

Gynecol Oncol 2021 Sep 7. Epub 2021 Sep 7.

Cancer Biology Research Center (Key Laboratory of the Ministry of Education), Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China; Department of Scientific Research, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China; Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. Electronic address:

Background: Gynecologic cancers seriously threaten women's life and health. This study aims to assess the long-term trends of mortality from the three major gynecologic cancers in China and to examine the age-, period-, and cohort-specific effects behind them during the period 1990 to 2019.

Methods: The mortality data of cervical, ovarian, and uterine cancer in China were obtained from the Global Burden of Disease Study 2019 and were analyzed with the age-period-cohort framework.

Results: It was found that the net drift for cervical cancer mortality was -0.19% (95% CI, -0.46% to 0.08%) per year, for ovarian cancer was 0.76% (95% CI, 0.57% to 0.95%) per year, and for uterine cancer was -3.09% (95% CI, -3.44% to -2.76%) per year from 1990 to 2019. During this period, while cervical cancer remained the most common cause of death among gynecologic cancers among Chinese women, ovarian cancer replaced uterine cancer as the second leading cause of death in gynecologic cancers after about 2005. Significant age, cohort, and period effects were found for the mortality trends of all three major gynecologic cancers.

Conclusions: The secular trends of mortality from the three major gynecologic cancers in China and their underlying age, period, and cohort effects are likely to reflect the progress of diagnosis and treatment, rapid socio-economic transitions, and the accompanying lifestyle and behavior changes. More priorities of further epidemiology studies and efforts on the prevention and control should be given to three major gynecologic cancers.
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http://dx.doi.org/10.1016/j.ygyno.2021.08.029DOI Listing
September 2021

The median effective concentration of propofol with different doses of esketamine during gastrointestinal endoscopy in elderly patients: a randomized controlled trial.

Br J Clin Pharmacol 2021 Sep 8. Epub 2021 Sep 8.

Department of Anesthesiology, Shidong Hospital of Shanghai, University of Shanghai for Science and Technology, Shanghai, China.

Background: Propofol may result in hypotension, bradycardia, and loss of protective reflexes, especially in elderly patients, while esketamine, a N-methyl-D-aspartate receptor antagonist, has analgesic, anaesthetic and sympathomimetic properties and is known to cause less cardiorespiratory depression. We hypothesized that esketamine may reduce the median effective concentration (EC ) of propofol and co-administration cause less likely to produce hypotension during gastrointestinal endoscopy in elderly patients.

Methods: Ninety elderly patients, aged 65-89 years, undergoing gastrointestinal endoscopy were randomly assigned into three groups: SK0 (control) group (0 mg/kg esketamine), SK0.25 group (0.25 mg/kg esketamine), and SK0.5 group (0.5 mg/kg esketamine). Anaesthesia was achieved by plasma target-controlled infusion of propofol with different bolus doses of esketamine. The EC of propofol for gastrointestinal endoscopy was determined by using the up-and-down method of Dixon. The initial plasma target concentration is 2.5 μg/ml and the adjacent concentration gradient is 0.5 μg/mL. Cardiovascular variables were also measured.

Results: Propofol EC s and its 95% confidence interval for gastrointestinal endoscopy in elderly patients were 3.69 (2.59-4.78), 2.45 (1.85-3.05) and 1.71 (1.15-2.27) μg/mL in SK0, SK0.25 and SK0.5 group (P < 0.05). The average percent change from baseline mean arterial pressure (MAP) was -19.7 (7.55), -15.2 (7.14) and -10.1 (6.73), in SK0, SK0.25 and SK0.5 group (P<0.001).

Conclusions: Combination medication of propofol with esketamine reduced the propofol EC during gastrointestinal endoscopy in elderly patients compared with administration of propofol without esketamine. Increasing doses of SK with propofol are less likely to produce hypotension with shorter recovery time.
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http://dx.doi.org/10.1111/bcp.15072DOI Listing
September 2021

[Simulating site index of using a random effect model in three provinces of Northeast China].

Ying Yong Sheng Tai Xue Bao 2020 Aug;31(8):2549-2557

Jilin Province Academy of Forestry Science, Changchun 130033, China.

To evaluate site quality and provide scientific evidence, the mixed effect model of polymorphic site index of was accurately simulated in the three provinces of Northeast China. A total of 197 plots in the 23 typical regions of Liaoning, Jilin and Heilongjiang provinces were set by the sample circle method, from which we got 1537 height-age data of . The site factors were divided, assigned and calculated using variance analysis and model fitting. The results showed that slope position was the dominant factor affecting the growth of dominant wood of , followed by soil depth, slope and aspect. After fitting and analyzing eight common basic models, we found that the logistic model =/[1+exp(+)] was the optimal one (=0.70), with a mean absolute error (MAE) of 2.52. When the four main influen-cing factors were randomly combined, the optimal site index model of the stochastic combination (M) was obtained with of 0.90, which improved the fitting accuracy of the base model. The -means clustering method was used to further divide the initial groups of site types into six groups. We established the nonlinear mixed effect model M, )/[1+exp (1.7352-0.0961, with and Akaike's information criterion (AIC) being 0.92 and 912.65, respectively, which could significantly improve the fitting and accuracy of the model. The equation could be used for the accurate evaluation of site quality of under the complex site types in the three provinces of Northeast China.
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http://dx.doi.org/10.13287/j.1001-9332.202008.006DOI Listing
August 2020

Expanded CAG/CTG repeats resist gene silencing mediated by targeted Epigenome editing.

Hum Mol Genet 2021 Sep 7. Epub 2021 Sep 7.

UK Dementia Research Institute at Cardiff University, Hadyn Ellis Building, Maindy Road, CF24 4HQ, Cardiff, United Kingdom.

Expanded CAG/CTG repeat disorders affect over 1 in 2500 individuals worldwide. Potential therapeutic avenues include gene silencing and modulation of repeat instability. However, there are major mechanistic gaps in our understanding of these processes, which prevent the rational design of an efficient treatment. To address this, we developed a novel system, ParB/ANCHOR-mediated Inducible Targeting (PInT), in which any protein can be recruited at will to a GFP reporter containing an expanded CAG/CTG repeat. Previous studies have implicated the histone deacetylase HDAC5 and the DNA methyltransferase DNMT1 as modulators of repeat instability via mechanisms that are not fully understood. Using PInT, we found no evidence that HDAC5 or DNMT1 modulate repeat instability upon targeting to the expanded repeat, suggesting that their effect is independent of local chromatin structure. Unexpectedly, we found that expanded CAG/CTG repeats reduce the effectiveness of gene silencing mediated by targeting HDAC5 and DNMT1. The repeat-length effect in gene silencing by HDAC5 was abolished by a small molecule inhibitor of HDAC3. Our results have important implications on the design of epigenome editing approaches for expanded CAG/CTG repeat disorders. PInT is a versatile synthetic system to study the effect of any sequence of interest on epigenome editing.
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http://dx.doi.org/10.1093/hmg/ddab255DOI Listing
September 2021

Genomic insights into the origin, domestication and diversification of Brassica juncea.

Nat Genet 2021 Sep 6;53(9):1392-1402. Epub 2021 Sep 6.

College of Agronomy, Hunan Agricultural University, Changsha, China.

Despite early domestication around 3000 BC, the evolutionary history of the ancient allotetraploid species Brassica juncea (L.) Czern & Coss remains uncertain. Here, we report a chromosome-scale de novo assembly of a yellow-seeded B. juncea genome by integrating long-read and short-read sequencing, optical mapping and Hi-C technologies. Nuclear and organelle phylogenies of 480 accessions worldwide supported that B. juncea is most likely a single origin in West Asia, 8,000-14,000 years ago, via natural interspecific hybridization. Subsequently, new crop types evolved through spontaneous gene mutations and introgressions along three independent routes of eastward expansion. Selective sweeps, genome-wide trait associations and tissue-specific RNA-sequencing analysis shed light on the domestication history of flowering time and seed weight, and on human selection for morphological diversification in this versatile species. Our data provide a comprehensive insight into the origin and domestication and a foundation for genomics-based breeding of B. juncea.
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http://dx.doi.org/10.1038/s41588-021-00922-yDOI Listing
September 2021

Effects of hillslope position on soil water infiltration and preferential flow in tropical forest in southwest China.

J Environ Manage 2021 Sep 3;299:113672. Epub 2021 Sep 3.

CAS Key Laboratory of Tropical Forest Ecology, Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences, Menglun, Yunnan, 666303, China; Center of Plant Ecology, Core Botanical Gardens, Chinese Academy of Sciences, Menglun, Yunnan, 666303, China. Electronic address:

The hillslope is an essential natural spatial gradient that influences hydrological processes by affecting water distribution, surface flow, soil erosion, and groundwater recharge. To date, few studies have addressed only the hydrological processes of tropical forest hillslopes. To reveal the effect of hillslope on soil hydrological functioning-including water distribution and exchange, infiltration capacity, and flow behaviour-we conducted 36 field infiltration and nine dye-tracer investigations of different hillslope locations in the natural rainforest of Xishuangbanna, southwest China. The soil physical properties-including soil noncapillary and total porosity, saturated water capacity, and field water capacity-decreased with decreasing elevation from hilltop to middle slope and the valley bottom. The water infiltration capacity-including the initial infiltration rate, saturated soil hydraulic conductivity, and average infiltration rate-decreased from the hilltop to the valley bottom. Preferential flow dominated soil water movement more in the upper locations than in the valley bottom. The infiltration capacity parameters and preferential flow were significantly correlated with soil water content, noncapillary and total porosity, root biomass, and termite holes. These results indicated that along with the soil physical properties, root systems, animal activity, cracks, and stones affected the soil infiltration capacity and preferential flow. Differences in the hydraulic processes of each hillslope position contributed to the redistribution, transportation, and storage of surface and belowground water, resulting in differing availabilities of soil water resources and utilisation by plants. The findings of this study can help understand eco-hydrological processes in the context of water resources management in tropical mountain ecosystems.
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http://dx.doi.org/10.1016/j.jenvman.2021.113672DOI Listing
September 2021

A Bibliometric Analysis of Pyroptosis From 2001 to 2021.

Front Immunol 2021 18;12:731933. Epub 2021 Aug 18.

Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China.

Background: Pyroptosis is a new programmed cell death discovered in recent years. Pyroptosis plays an important role in various diseases. Nevertheless, there are few bibliometric analysis systematically studies this field. We aimed to visualize the research hotspots and trends of pyroptosis using a bibliometric analysis to help understand the future development of basic and clinical research.

Methods: The articles and reviews regarding pyroptosis were culled from Web of Science Core Collection. Countries, institutions, authors, references and keywords in this field were visually analyzed by using CtieSpace and VOSviewer software.

Results: A total of 2845 articles and reviews were included. The number of articles regarding pyroptosis significantly increased yearly. These publications mainly come from 70 countries led by China and the USA and 418 institutions. We identified 605 authors, among which Thirumaladevi Kanneganti had the most significant number of articles, and Shi JJ was co-cited most often. was the journal with the most studies, and was the most commonly cited journal. After analysis, the most common keywords are nod like receptor family pyrin domain containing 3 inflammasome, apoptosis, cell death, gasdermin D, mechanism, caspase-1, and others are current and developing areas of study.

Conclusion: Research on the pyroptosis is flourishing. Cooperation and exchanges between countries and institutions must be strengthened in the future. The related pathway mechanism of pyroptosis, the relationship between pyroptosis and other types of programmed cell deaths as well as the role of pyroptosis in various diseases have been the focus of current research and developmental trends in the future research.
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http://dx.doi.org/10.3389/fimmu.2021.731933DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8416445PMC
August 2021

Trio exome sequencing identified a novel de novo WASF1 missense variant leading to recurrent site substitution in a Chinese patient with developmental delay, microcephaly, and early-onset seizures: A mutational hotspot p.Trp161 and literature review.

Clin Chim Acta 2021 Aug 31;523:10-18. Epub 2021 Aug 31.

Department of Neurology, Children's Hospital of Soochow University, 92 Zhongnan Street, Suzhou Industrial Park, Suzhou 215025, Jiangsu, China. Electronic address:

Background: Neurodevelopmental disorder with absent language and variable seizures (NEDALVS, OMIM # 618707) is a newly described autosomal dominant condition caused by heterozygous de novo mutation in WASF1 gene. WASF1 is a key component of the WAVE regulatory complex (WRC) required for actin polymerization. So far, only 3 distinct truncating variants clustering at the WCA domain, 3 missense variants localized to the meander region and a copy number variant (CNV) of WASF1 have been identified among 11 NEDALVS cases previously reported.

Case Report: We report a pediatric patient carrying novel de novo heterozygous missense variant (NM_003931.2: c.481T > C, p.Trp161Arg) in WASF1 gene. During the first hospitalization at age of 5.5 months, the patient was initially diagnosed with infantile spasms, developmental delay (DD) and microcephaly due to nodding-like epileptic spasms in clusters and hypsarrhythmia on video-electroencephalography, lacking head control and body rollover, and abnormal head circumference 39 cm (<-2SD). The genetic diagnosis with a causal WASF1 variant detected by trio exome sequencing indicated the rare NEDALVS.

Literature Review: All the reported NEDALVS cases published in the PubMed English literature were reviewed to summarize the genetic and phenotypic spectrum of this novel disorder.

Conclusion: We describe the third patient with a recurrently mutated amino acid site at p.Trp161 in WASF1, currently the 12th patient with NEDALVS. This hotspot missense variant and the truncating variants in WASF1 lead to similar phenotypic patterns with core features of severe DD/ID, and seizures, hypotonia, and microcephaly frequently observed. Our finding expands the WASF1 mutation spectrum and confirms the de novo hotspot missense variant at p.Trp161, further supporting the association of the novel NEDALVS with WASF1 gene and the actin regulatory pathway.
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http://dx.doi.org/10.1016/j.cca.2021.08.030DOI Listing
August 2021

Radiomics features on ultrasound imaging for the prediction of disease-free survival in triple negative breast cancer: a multi-institutional study.

Br J Radiol 2021 Oct 3;94(1126):20210188. Epub 2021 Sep 3.

Department of Information, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Objectives: To explore the predictive value of radiomics nomogram using pretreatment ultrasound for disease-free survival (DFS) after resection of triple negative breast cancer (TNBC).

Methods And Materials: A total of 486 TNBC patients from 3 different institutions were consecutively recruited for this study. They were categorized into the primary cohort ( = 216), as well as the internal validation cohort ( = 108) and external validation cohort ( = 162). In primary cohort, least absolute shrinkage and selection operator logistic regression algorithm was used to select recurrence-related radiomics features extracted from the breast tumor and peritumor regions, and a radiomics signature was constructed derived from the grayscale ultrasound images. A radiomic nomogram integrating independent clinicopathological variables and radiomic signature was established with uni- and multivariate cox regressions. The predictive nomogram was validated using an internal cohort and an independent external cohort regarding abilities of discrimination, calibration and clinical usefulness.

Results: The patients with higher Rad-score had a worse prognostic outcome than those with lower Rad-score in primary cohort and two validation cohorts (All < 0.05).The radiomics nomogram indicated more effective prognostic performance compared with the clinicopathological model and tumor node metastasis staging system (), with a training C-index of 0.75 (95% confidence interval (CI), 0.71-0.80), an internal validation C-index of 0.73 (95% CI, 0.69-0.78) and an external validation 0.71 (95% CI,0.66-0.76). Moreover, the calibration curves revealed a good consistency for survival prediction of the radiomics model.

Conclusions: The ultrasound-based radiomics signature was a promising biomarker for risk stratification for TNBC patients. Furthermore, the proposed radiomics modal integrating the optimal radiomics features and clinical data provided individual relapse risk accurately.

Advances In Knowledge: The radiomics model integrating radiomic signature and independent clinicopathological variables could improve individual prognostic evaluation and facilitate therapeutic decision-making, which demonstrated the incremental value of the radiomics signature for prognostic prediction in TNBC.
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http://dx.doi.org/10.1259/bjr.20210188DOI Listing
October 2021

Gold-catalyzed oxidation of terminal alkynes to glyoxals and their reactions with 2-phenylimidazo[1,2-]pyridines: one-pot synthesis of 1,2-diones.

Org Biomol Chem 2021 Sep 3. Epub 2021 Sep 3.

CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, Research Center for Marine Microbes, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, 510301, China.

A novel one-pot protocol for the convenient and efficient synthesis of (2-phenylimidazo[1,2-]pyridin-3-yl)alkane-1,2-diones (3) in good yields (32-88%) from 2-phenylimidazo[1,2-]pyridines (1) and terminal alkynes (2) has been established with a wide range of substrate scope. A tandem reaction sequence containing gold-catalyzed double oxidations of terminal alkynes to generate glyoxals, nucleophilic addition of 2-phenylimidazo[1,2-]pyridines to glyoxals to yield α-hydroxyl ketones, and oxygenation of the α-hydroxyl ketones to afford the final products 3 under air atmosphere is involved in this method. Simple operation, mild reaction conditions, and widely available substrates make this strategy more affordable.
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http://dx.doi.org/10.1039/d1ob01507aDOI Listing
September 2021

A rapid compression machine coupled with time-resolved molecular beam mass spectrometry for gas-phase kinetics studies.

Rev Sci Instrum 2021 Aug;92(8):084103

Center for Combustion Energy and Key Laboratory for Thermal Science and Power Engineering of MOE, Tsinghua University, Beijing 100084, China.

Rapid compression machines (RCMs) are used to simulate a single stroke of an internal combustion engine. After a high-speed compression process, a high-pressure and low-to-intermediate temperature condition can be obtained, under which ignition processes are usually studied. With the help of different diagnostic methods, the detailed speciation information of the ignition process can be quantified. In this study, the molecular beam mass spectrometry (MBMS) diagnostic method was applied on an RCM to realize time-resolved concentration profile measurements. To realize the combination between RCM and MBMS, particle dampers were adopted to suppress the vibrations of the RCM, and a novel flexible interface was designed to maintain a high vacuum, which ensured the safe and effective operation of a high-repetition-rate time-of-flight mass spectrometer (HRR-TOF-MS). The detailed configuration of this diagnostic method is presented, and the data acquisition system and data analysis method are described. The arrangement was validated through the investigation of the well-studied decomposition of 1,3,5-trioxane at temperatures between 697 and 777 K at 10 bars. The measured concentration profiles of 1,3,5-trioxane and formaldehyde were in good agreement with previous experimental and theoretical calculation results. The experimental results showed that the newly developed RCM coupled with the HRR-TOF-MS has advantages in time-resolved speciation measurements at low-to-intermediate temperatures and high pressures, and it can be applied in low-temperature combustion chemical kinetics studies.
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http://dx.doi.org/10.1063/5.0055585DOI Listing
August 2021

Mental health on the move: An observational study to characterize post-migration depression symptoms among migrants from Sub-Saharan Africa in China.

J Psychosom Res 2021 Oct 24;149:110602. Epub 2021 Aug 24.

Dermatology Hospital of Southern Medical University, Guangzhou, China; Southern Medical University Institute for Global Health and Sexually Transmitted Diseases, Guangzhou, China; Guangdong Provincial Center for Skin Disease and STI Control, Guangzhou, Guangdong, China. Electronic address:

Objective: Migrants from Sub-Saharan Africa to China faced challenges in accessing healthcare. Less is known about their depression prevalence. We aim to address this gap by providing an initial estimation on symptoms indicative of depression.

Methods: A cross-sectional survey was conducted from August to October in 2019. Eligibility was defined as being originally from a Sub-Saharan African country and cumulative residence in China for at least one month. A convenience sample was drawn from snowball sampling online and venue-based sampling by community outreach. The primary outcome, symptoms indicative of depression, were measured by the Centre for Epidemiologic Studies Depression Scale using 16 as the cutoff. Multivariable logistic regressions were employed to examine the association between depression symptoms and their migration-related correlates. Data were analyzed using SAS 9.4.

Results: The prevalence of symptoms indicative of depression assessed by CES-D was high at 44% among 928 participants when using 16 as a cutoff. Depression symptoms were associated with unsatisfactory housing conditions (aOR: 1.7, 95%CI: 0.8 to 3.3) and perception of very unfriendly attitudes from the local people (aOR: 4.5, 95%CI: 1.2 to 16.1) after adjusting for covariates.

Conclusions: Depression symptoms were prevalent among SSA migrants in China and warrants attention and intervention. Support should be provided during the post-migration period in China to mitigate depression risks. Future studies are needed to build more evidence on SSA migrants' mental health and to inform global health policies and programming.
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http://dx.doi.org/10.1016/j.jpsychores.2021.110602DOI Listing
October 2021

Synergistic Effect of Atomically Dispersed Ni-Zn Pair Sites for Enhanced CO Electroreduction.

Adv Mater 2021 Aug 31:e2102212. Epub 2021 Aug 31.

College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, 310027, China.

Dual-atom catalysts have the potential to outperform the well-established single-atom catalysts for the electrochemical conversion of CO . However, the lack of understanding regarding the mechanism of this enhanced catalytic process prevents the rational design of high-performance catalysts. Herein, an obvious synergistic effect in atomically dispersed Ni-Zn bimetal sites is observed. In situ characterization combined with density functional theory (DFT) calculations reveals that heteronuclear coordination modifies the d-states of the metal atom, narrowing the gap between the d-band centre (ε ) of the Ni (3d) orbitals and the Fermi energy level (E ) to strengthen the electronic interaction at the reaction interface, resulting in a lower free energy barrier (ΔG) in the thermodynamic pathway and a reduced activation energy (E ) as well as fortified metal-C bonding in the kinetic pathway. Consequently, a CO faradaic efficiency of >90% is obtained across a broad potential window from -0.5 to -1.0 V (vs RHE), reaching a maximum of 99% at -0.8 V, superior to that of the Ni/Zn single-metal sites.
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http://dx.doi.org/10.1002/adma.202102212DOI Listing
August 2021

Hemodynamic Versus Anatomic Assessment of Symptomatic Atherosclerotic Middle Cerebral Artery Stenosis: the Relationship Between Pressure Wire Translesional Gradient and Angiographic Lesion Geometry.

Front Neurol 2021 11;12:671778. Epub 2021 Aug 11.

Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China.

Intracranial cerebral atherosclerosis (ICAS) is a leading etiology of ischemic stroke. The diagnosis and assessment of intracranial stenosis are shifting from anatomic to hemodynamic for better risk stratification. However, the relationships between lesion geometry and translesional pressure gradient have not been clearly elucidated. Patients with symptomatic unifocal M1 middle cerebral artery (M1-MCA) stenosis were consecutively recruited. The translesional pressure gradient was measured with a pressure wire and was recorded as both mean distal/proximal pressure ratios (Pd/Pa) and translesional pressure difference (Pa-Pd). Lesion geometry measured on angiography was recorded as diameter stenosis, minimal lumen diameter, and lesion length. The correlations between pressure-derived and angiography-derived indices were then analyzed. Forty-three patients were analyzed. A negative correlation was found between Pd/Pa and diameter stenosis ( = -0.371; = 0.014) and between Pa - Pd and minimal lumen diameter ( = -0.507; = 0.001). A positive correlation was found between Pd/Pa and minimal lumen diameter ( = 0.411; = 0.006) and between Pa - Pd and diameter stenosis ( = 0.466; = 0.002). In a highly selected ICAS subgroup, geometric indices derived from angiography correlate significantly with translesional pressure gradient indices. However, the correlation strength is weak-to-moderate, which implies that anatomic assessment could only partly reflect hemodynamic status. Translesional pressure gradient measured by pressure wire may serve as a more predictive marker of ICAS severity. More factors need to be identified in further studies.
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http://dx.doi.org/10.3389/fneur.2021.671778DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8385769PMC
August 2021

Computer Vision-Based Construction Process Sensing for Cyber-Physical Systems: A Review.

Sensors (Basel) 2021 Aug 13;21(16). Epub 2021 Aug 13.

Department of Structural Engineering, Tongji University, 1239 Siping, Shanghai 200092, China.

Cyber-physical systems (CPSs) are generally considered to be the next generation of engineered systems. However, the actual application of CPSs in the Architecture, Engineering and Construction (AEC) industry is still at a low level. The sensing method in the construction process plays a very important role in the establishment of CPSs. Therefore, the purpose of this paper is to discuss the application potential of computer vision-based sensing methods and provide practical suggestions through a literature review. This paper provides a review of the current application of CPSs in the AEC industry, summarizes the current knowledge gaps, and discusses the problems with the current construction site sensing approach. Considering the unique advantages of the computer vision (CV) method at the construction site, the application of CV for different construction entities was reviewed and summarized to achieve a CV-based construction site sensing approach for construction process CPSs. The potential of CPS can be further stimulated by providing rich information from on-site sensing using CV methods. According to the review, this approach has unique advantages in the specific environment of the construction site. Based on the current knowledge gap identified in the literature review, this paper proposes a novel concept of visual-based construction site sensing method for CPS application, and an architecture for CV-based CPS is proposed as an implementation of this concept. The main contribution of this paper is to propose a CPS architecture using computer vision as the main information acquisition method based on the literature review. This architecture innovatively introduces computer vision as a sensing method of construction sites, and realizes low-cost and non-invasive information acquisition in complex construction scenarios. This method can be used as an important supplement to on-site sensing to further promote the automation and intelligence of the construction process.
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http://dx.doi.org/10.3390/s21165468DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8400116PMC
August 2021

Lightweight, Robust, Conductive Composite Fibers Based on [email protected] Nanofibers as Sensors for Smart Fabrics.

ACS Appl Mater Interfaces 2021 Sep 27;13(35):41933-41945. Epub 2021 Aug 27.

College of Bioresources Chemical and Materials Engineering, National Demonstration Center for Experimental Light Chemistry Engineering Education, Shaanxi Province Key Laboratory of Papermaking Technology and Specialty Paper Development, Shaanxi University of Science & Technology, No. 6, Xuefu Road, Xi'an 710021, China.

Developing one-dimensional fiber-based sensors to meet the requirement of spinnability, portability, flexibility, and easeful conformability in smart wearable devices has attracted increasing interest. Here, we report highly conductive [email protected] nanofibers (ANFs) with a distinct skin-core structure by the wet spinning method. MXene, an emerging 2D conductive material, is applied to build internal conductive paths. ANF frameworks function as protective and skeleton structures to reduce the fiber oxidation probability and achieve superior strength. The obtained [email protected] fiber with superior conductivity (2515 S m) and tensile strength (130 MPa) works as a promising sensor for smart fabrics to detect different human movements with abundant detection motions, fast response time (100 ms), and long service life (up to 1000 cycles). Benefiting from its high flexibility, it can be sewn into textile and gloves as a smart wearable device. Besides superior thermal stability, it shows promising electrothermal properties with wide heating temperature (25-123 °C) and fast heating temperature (10 s). Therefore, the [email protected] fiber with the skin-core structure shows great potential as a promising sensor to be applied in electric heating and smart wearable fabrics.
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http://dx.doi.org/10.1021/acsami.1c13645DOI Listing
September 2021
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