Publications by authors named "Bin Yan"

694 Publications

Benchmarking Information Scrambling.

Phys Rev Lett 2022 Jul;129(5):050602

Theoretical Division, Los Alamos National Laboratory, Los Alamos, New Mexico 87545, USA.

Information scrambling refers to the rapid spreading of initially localized information over an entire system, via the generation of global entanglement. This effect is usually detected by measuring a temporal decay of the out-of-time order correlators. However, in experiments, decays of these correlators suffer from fake positive signals from various sources, e.g., decoherence due to inevitable couplings to the environment, or errors that cause mismatches between the purported forward and backward evolutions. In this Letter, we provide a simple and robust approach to single out the effect of genuine scrambling. This allows us to benchmark the scrambling process by quantifying the degree of the scrambling from the noisy backgrounds. We also demonstrate our protocol with simulations on IBM cloud-based quantum computers.
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http://dx.doi.org/10.1103/PhysRevLett.129.050602DOI Listing
July 2022

Panax notoginseng saponin reduces -stimulated apoptosis and endoplasmic reticulum stress of nucleus pulposus cells by suppressing .

Ann Transl Med 2022 Jul;10(13):748

Department of Spine Surgery, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen, China.

Background: It is well documented that the malignant biological behaviors of nucleus pulposus cells (NPCs) could trigger intervertebral disc degeneration (IDD). Panax notoginseng saponin (PNS) is a traditional Chinese medicine that inhibits osteoclastogenesis. However, its effects on the phenotypes of NPCs in IDD remains largely unknown. This study sought to examine the role of PNS in IDD and its regulatory mechanism.

Methods: First, human NPCs (hNPCs) were treated with interleukin-1 beta () to induce an IDD cell model. Cell proliferation and apoptosis were estimated by Cell Counting Kit-8 (CCK-8) and terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assays. Western blot was employed to examine the levels of proteins related to apoptosis and endoplasmic reticulum (ER) stress. Enzyme-linked immunosorbent assays (ELISAs) were used to test inflammatory factors levels. Immunofluorescence (IF) assays were used to determine the nuclear translocation of nuclear factor-kappa beta () . Reverse transcription-quantitative polymerase chain reaction (RT-qPCR)was used to detect expression.

Results: We discovered that PNS enhanced the viability but reduced the apoptosis, inflammation, and ER stress response of -induced hNPCs in a concentration-dependent manner. Additionally, PNS significantly reduced expression in the -induced hNPCs. Notably, these PNS effects were reversed by the upregulation of .

Conclusions: In summary, PNS appears to facilitate the proliferation and attenuate the apoptosis, inflammatory response, and ER stress response of -induced hNPCs by inhibiting expression. Our findings provide a theoretical basis for a novel drug application in IDD research.
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http://dx.doi.org/10.21037/atm-22-3203DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9358501PMC
July 2022

Prior Guided Transformer for Accurate Radiology Reports Generation.

IEEE J Biomed Health Inform 2022 Aug 8;PP. Epub 2022 Aug 8.

In this paper, we propose a prior guided transformer for accurate radiology reports generation. In the encoder part, a radiograph is firstly represented by a set of patch features, which is obtained through a convolutional neural network and a traditional transformer encoder. Then an Additive Gaussian model is applied to represent the prior knowledge based on unsupervised clustering and sparse attention. In the decoder part, prior embeddings are acquired by probabilistically sampling from the radiograph prior. Then the visual features, language embeddings, and prior embeddings are fused by our proposed Prior Guided Attention to generate accurate radiology reports. Experiment results show that our method achieves better performance than state-of-the-art methods on two public radiology datasets, which proves the effectiveness of our prior guided transformer.
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http://dx.doi.org/10.1109/JBHI.2022.3197162DOI Listing
August 2022

Association of ST-T changes with all-cause mortality among patients with peripheral T-cell lymphomas.

Open Med (Wars) 2022 12;17(1):1252-1258. Epub 2022 Jul 12.

Department of Haematology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.

Research has suggested a significant prognostic value of ST-T changes in various cardiovascular diseases and malignant tumors. However, their role in predicting prognosis in patients with peripheral T-cell lymphomas (PTCLs) remains unknown. Here, we investigated the prognostic potential of ST-T changes in all-cause mortality of PTCLs patients. In total, 131 patients with PTCLs between January 2015 and April 2020 were enrolled. Univariable and multivariable COX proportional hazards regression models were used to find the relationship between ST-T changes and all-cause mortality in these patients. A significant difference in all-cause mortality was found between patients with ST-T abnormalities and those without definite abnormalities in the ST-T segments ( = 0.027). Multivariable Cox risk regression analysis indicated that patients with ST-T changes had greater all-cause mortality than patients with normal ST-T segments in the intermediate-high/high-risk groups ( < 0.001). In addition, ST-T changes were markedly distinction in patients with hypoproteinemia than in those with no definite abnormalities in the ST-T segments ( = 0.021). ST-T changes may serve as potential, simple, and effective prognostic factors for all-cause mortality in PTCLs patients, especially in the intermediate-high/high-risk and hypoproteinemia groups. Therefore, regular ECG monitoring is recommended to guide the clinical treatment of patients with PTCLs.
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http://dx.doi.org/10.1515/med-2022-0517DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9281589PMC
July 2022

Multiscale Dense U-Net: A Fast Correction Method for Thermal Drift Artifacts in Laboratory NanoCT Scans of Semi-Conductor Chips.

Entropy (Basel) 2022 Jul 13;24(7). Epub 2022 Jul 13.

Henan Key Laboratory of Imaging and Intelligent Processing, PLA Strategic Support Force Information Engineering University, Zhengzhou 450001, China.

The resolution of 3D structure reconstructed by laboratory nanoCT is often affected by changes in ambient temperature. Although correction methods based on projection alignment have been widely used, they are time-consuming and complex. Especially in piecewise samples (e.g., chips), the existing methods are semi-automatic because the projections lose attenuation information at some rotation angles. Herein, we propose a fast correction method that directly processes the reconstructed slices. Thus, the limitations of the existing methods are addressed. The method is named multiscale dense U-Net (MD-Unet), which is based on MIMO-Unet and achieves state-of-the-art artifacts correction performance in nanoCT. Experiments show that MD-Unet can significantly boost the correction performance (e.g., with three orders of magnitude improvement in correction speed compared with traditional methods), and MD-Unet+ improves 0.92 dB compared with MIMO-Unet in the chip dataset.
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http://dx.doi.org/10.3390/e24070967DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9319506PMC
July 2022

Short-term health impacts related to ozone in China before and after implementation of policy measures: A systematic review and meta-analysis.

Sci Total Environ 2022 Jul 23;847:157588. Epub 2022 Jul 23.

Faculty of Geo-Information Science and Earth Observation (ITC), University of Twente, Enschede 7514AE, the Netherlands. Electronic address:

This paper presents a meta-analysis of the impacts of short-term exposure to ozone (O) on three health endpoints: all-cause, cardiovascular, and respiratory mortality in China. All relevant studies from January 1990 to December 2021 were searched from four databases. After screening, 30 studies were included for the meta-analysis. The results showed that a significant rise of 0.41 % (95 % confidence interval (CI): 0.35 %-0.48 %) in all-cause, 0.60 % (95 % CI: 0.51 %-0.68 %) in cardiovascular and 0.45 % (95 % CI: 0.28 %-0.62 %) in respiratory mortality for each 10 μg m increase in the maximum daily 8 h average O concentration (MDA8 O). Moreover, results stratified by heterogeneous time periods before and after implementing a policy measure in 2013, showed that the pooled effects for all-cause and respiratory mortality before were greater than those after, while the pooled effects for cardiovascular mortality before 2013 were slightly smaller than those after. The finding that short-term exposure to O was positively related to the three health endpoints was validated by means of a sensitivity analysis. Furthermore, we did not observe any publication bias. Our results present an updated and better understanding of the relationship between short-term exposure to O and the three health endpoints, while providing a reference for further assessment of the impact of short-term O exposure on human health.
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http://dx.doi.org/10.1016/j.scitotenv.2022.157588DOI Listing
July 2022

Establishment and Evaluation of Artificial Intelligence-Based Prediction Models for Chronic Kidney Disease under the Background of Big Data.

Evid Based Complement Alternat Med 2022 8;2022:6561721. Epub 2022 Jul 8.

Department of Nephropathy, Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang 310012, China.

Objective: To establish a prediction model for the risk evaluation of chronic kidney disease (CKD) to guide the management and prevention of CKD.

Methods: A total of 1263 patients with CKD and 1948 patients without CKD admitted to the Tongde Hospital of the Zhejiang Province from January 1, 2008, to December 31, 2018, were retrospectively analyzed. Spearman's correlation was used to analyze the relationship between CKD and laboratory parameters. XGBoost, random forest, Naive Bayes, support vector machine, and multivariate logistic regression algorithms were employed to establish prediction models for the risk evaluation of CKD. The accuracy, precision, recall, F1 score, and area under the receiver operating curve (AUC) of each model were compared. The new bidirectional encoder representations from transformers with light gradient boosting machine (MD-BERT-LGBM) model was used to process the unstructured data and transform it into researchable unstructured vectors, and the AUC was compared before and after processing.

Results: Differences in laboratory parameters between CKD and non-CKD patients were observed. The neutrophil ratio and white blood cell count were significantly associated with the occurrence of CKD. The XGBoost model demonstrated the best prediction effect (accuracy = 0.9088, precision = 0.9175, recall = 0.8244, F1 score = 0.8868, AUC = 0.8244), followed by the random forest model (accuracy = 0.9020, precision = 0.9318, recall = 0.7905, F1 score = 0.581, AUC = 0.9519). Comparatively, the predictions of the Naive Bayes and support vector machine models were inferior to those of the logistic regression model. The AUC of all models was improved to some extent after processing using the new MD-BERT-LGBM model.

Conclusion: The new MD-BERT-LGBM model with the inclusion of unstructured data has contributed to the higher accuracy, sensitivity, and specificity of the prediction models. Clinical features such as age, gender, urinary white blood cells, urinary red blood cells, thrombin time, serum creatinine, and total cholesterol were associated with CKD incidence.
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http://dx.doi.org/10.1155/2022/6561721DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9286960PMC
July 2022

Redundantly Amplified Information Suppresses Quantum Correlations in Many-Body Systems.

Phys Rev Lett 2022 Jul;129(1):010401

Theoretical Division, Los Alamos National Laboratory, Los Alamos, New Mexico 87545, USA.

We establish bounds on quantum correlations in many-body systems. They reveal what sort of information about a quantum system can be simultaneously recorded in different parts of its environment. Specifically, independent agents who monitor environment fragments can eavesdrop only on amplified and redundantly disseminated-hence, effectively classical-information about the decoherence-resistant pointer observable. We also show that the emergence of classical objectivity is signaled by a distinctive scaling of the conditional mutual information, bypassing hard numerical optimizations. Our results validate the core idea of quantum Darwinism: objective classical reality does not need to be postulated and is not accidental, but rather a compelling emergent feature of quantum theory that otherwise-in the absence of decoherence and amplification-leads to "quantum weirdness." In particular, a lack of consensus between agents that access environment fragments is bounded by the information deficit, a measure of the incompleteness of the information about the system.
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http://dx.doi.org/10.1103/PhysRevLett.129.010401DOI Listing
July 2022

Serum Cystatin C Level Monitoring for Intervention Opportunity of CBP in Children with Severe Sepsis.

Evid Based Complement Alternat Med 2022 29;2022:8571203. Epub 2022 Jun 29.

Department of PICU, Gansu Provincial Maternity and Child-Care Hospital, Lanzhou 730050, Gansu, China.

Objective: The aim of this study is to investigate the instruction value of the serum cystatin C (Cys C) level monitoring for intervention opportunity of continuous blood purification technology (CBP) in children with severe sepsis.

Methods: 67 children with severe sepsis in the pediatric intensive care unit (PICU) with CBP treatment were retrospectively selected from May 2016 to April 2020. According to the time intervals between the time point of serum Cys C level began to increase (>15 mg/L) and the time point of CBP began, all children were divided into group A (<24 h, 29 cases), group B (24-48 h, 22 cases), and group C (>48 h, 16 cases). The children's general characteristics, vital signs, biochemical parameters, acute physiology and chronic health evaluation (APACHE II), and sequential organ failure assessment (SOFA) scores were evaluated. The influence factors of prognosis of children with severe sepsis were analyzed by multivariate regression analysis.

Results: The intervals between the time point of PICU hospitalization and the time point of CBP began and the times of CBP in group A were significantly more than those in group B and C ( < 0.05). There was no statistically significant duration of CBP among three groups ( > 0.05). After follow-up of 28 d, there was no significant difference on the occurrence of coagulation disorders and hypovolemic shock induced by CBP among three groups ( > 0.05). However, the mortality of children in group A was lower than that in group C ( < 0.05). Children in group A had lower APACHE II scores, SOFA scores, serum +, blood urea nitrogen (BUN), serum creatine (SCr), partial pressure of carbon dioxide (PCO), and higher partial pressure of oxygen (PO) than those of children in group C after CBP. ( < 0.05). SOFA scores ≥5 after CBP treatment and the time intervals between the time point of serum Cys C level began to increase (>15 mg/L) and the time point of CBP began ≥24 h were the independent influence factors on the prognosis by multivariate regression analysis.

Conclusion: There are significant evidences that continuous blood purification technology within 24 h of serum Cys C level may better control the condition of children with severe sepsis.
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http://dx.doi.org/10.1155/2022/8571203DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9259228PMC
June 2022

VDR promotes nucleus pulposus cell mitophagy as a protective mechanism against oxidative stress injury.

Free Radic Res 2022 Mar-Apr;56(3-4):316-327. Epub 2022 Jul 4.

Division of Spine Surgery, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou, P.R. China.

Intervertebral disk degeneration (IDD) is a common aging disease. Excessive apoptosis of nucleus pulposus (NP) cells has been widely considered a main contributor to IDD. Emerging science has shown that autophagy plays a protective role against apoptosis under oxidative stress. Vitamin D receptor (VDR) is a steroid hormone receptor that can regulate autophagy. The purpose of this study was to clarify whether VDR alleviates IDD by promoting autophagy. HO stimulation was used to establish oxidative stress conditions. Initially, the expression level of VDR in human degenerative NP tissues was measured by immunohistochemistry. In addition, the CRISPR-dCas9-VPR system and siRNA were utilized to upregulate or downregulate VDR and Parkin expression, respectively. Autophagic and apoptotic markers were determined by Western blotting and RT-qPCR. Transmission electron microscopy was used to monitor the occurrence of autophagy in rat NP cells. VDR expression was downregulated in human degenerative NP tissues and HO-stimulated rat NP cells, indicating a negative correlation between VDR expression and IDD. VDR overexpression promoted mitophagy and prevented apoptosis and mitochondrial injury under oxidative stress. Additionally, mitophagy inhibition by 3-MA abolished the protective effect of VDR activation . Furthermore, VDR activation promoted mitophagy the PINK1/Parkin pathway in HO-treated NP cells. This study demonstrates that VDR activation ameliorates oxidative damage and decreases NP cell apoptosis by promoting PINK1/Parkin-dependent mitophagy, indicating that VDR may serve as a promising therapeutic target in the management of IDD.
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http://dx.doi.org/10.1080/10715762.2022.2094791DOI Listing
July 2022

Mitogenomic phylogeny of Typhlocybinae (Hemiptera: Cicadellidae) reveals homoplasy in tribal diagnostic morphological traits.

Ecol Evol 2022 Jul 6;12(6):e8982. Epub 2022 Jun 6.

Institute of Entomology Guizhou University Guiyang Guizhou China.

The subfamily Typhlocybinae is a ubiquitous, highly diverse group of mostly tiny, delicate leafhoppers. The tribal classification has long been controversial and phylogenetic methods have only recently begun to test the phylogenetic status and relationships of tribes. To shed light on the evolution of Typhlocybinae, we performed phylogenetic analyses based on 28 newly sequenced and 19 previously sequenced mitochondrial genomes representing all currently recognized tribes. The results support the monophyly of the subfamily and its sister-group relationship to Mileewinae. The tribe Zyginellini is polyphyletic with some included genera derived independently within Typhlocybini. Ancestral character state reconstruction suggests that some morphological characters traditionally considered important for diagnosing tribes (presence/absence of ocelli, development of hind wing submarginal vein) are homoplastic. Divergence time estimates indicate that the subfamily arose during the Middle Cretaceous and that the extant tribes arose during the Late Cretaceous. Phylogenetic results support establishment of a new genus, Yan & Yang gen. nov., with two new species, Yan & Yang sp. nov. and Yan & Yang sp. nov.; but indicate that two previously recognized species of distinguished only by the direction of curvature of the processes of the aedeagus are synonyms, that is, Yan & Yang, 2017 equals Yan & Yang, 2017 syn. nov. A key to tribes of Typhlocybinae is provided.
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http://dx.doi.org/10.1002/ece3.8982DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9170537PMC
July 2022

EEG Identity Authentication in Multi-Domain Features: A Multi-Scale 3D-CNN Approach.

Front Neurorobot 2022 16;16:901765. Epub 2022 Jun 16.

Henan Key Laboratory of Imaging and Intelligent Processing, People's Liberation Army (PLA) Strategic Support Force Information Engineering University, Zhengzhou, China.

Electroencephalogram (EEG) authentication has become a research hotspot in the field of information security due to its advantages of living, internal, and anti-stress. However, the performance of identity authentication system is limited by the inherent attributes of EEG, such as low SNR, low stability, and strong randomness. Researchers generally believe that the in-depth fusion of features can improve the performance of identity authentication and have explored among various feature domains. This experiment invited 70 subjects to participate in the EEG identity authentication task, and the experimental materials were visual stimuli of the self and non-self-names. This paper proposes an innovative EEG authentication framework, including efficient three-dimensional representation of EEG signals, multi-scale convolution structure, and the combination of multiple authentication strategies. In this work, individual EEG signals are converted into spatial-temporal-frequency domain three-dimensional forms to provide multi-angle mixed feature representation. Then, the individual identity features are extracted by the various convolution kernel of multi-scale vision, and the strategy of combining multiple convolution kernels is explored. The results show that the small-size and long-shape convolution kernel is suitable for ERP tasks, which can obtain better convergence and accuracy. The experimental results show that the classification performance of the proposed framework is excellent, and the multi-scale convolution method is effective to extract high-quality identity characteristics across feature domains. The results show that the branch number matches the EEG component number can obtain the excellent cost performance. In addition, this paper explores the network training performance for multi-scale module combination strategy and provides reference for deep network construction strategy of EEG signal processing.
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http://dx.doi.org/10.3389/fnbot.2022.901765DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9243312PMC
June 2022

Magnetic hyperthermia induces effective and genuine immunogenic tumor cell death with respect to exogenous heating.

J Mater Chem B 2022 Jul 20;10(28):5364-5374. Epub 2022 Jul 20.

Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Provincial Key Laboratory of Biotechnology of Shaanxi Province, Northwest University, Xi'an, Shaanxi 710069, China.

Immunogenic cell death (ICD) can improve the therapeutic effects of cancer immunotherapy by initiating adaptive immune responses. Unlike the exogenous hyperthermia modality in clinics, magnetic hyperthermia (MH) is characterized by an iron oxide nano-agent acting as a heating source and the effects induced by heating acting at the intracellular region. However, the immunological effects of endogenous heating generated during MH and exogenous heating, and the difference in damage-associated molecular pattern (DAMP) emissions correlating with the ICD are unclear; whether MH elicits genuine ICD remains unknown. Herein, we have identified 10 distinct DAMP correlates of ICD induced by intracellular MH, and found that only heat shock proteins 70/90 were expressed after water bath heating (exogenous hyperthermia) in human triple-negative breast cancer (TNBC) MDA-MB-231 cells, murine TNBC 4T1 cells, and surgically resected specimens of ductal breast cancer from patients. vaccination assays were performed in immunocompetent BALB/c mice. The results demonstrated that MH with endogenous heating could stimulate the genuine ICD on 4T1 cells and achieved optimal therapeutic effects on 4T1 tumors, whereas exogenous heating under the same conditions failed to elicit these effects. These findings with regard to the MH induced genuine ICD with high efficiency are critical for the development of safe and effective therapeutics to amplify the therapeutic responses of cancer immunotherapy.
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http://dx.doi.org/10.1039/d2tb01004fDOI Listing
July 2022

Mechanical force modulates macrophage proliferation via Piezo1-AKT-Cyclin D1 axis.

FASEB J 2022 Aug;36(8):e22423

Department of Orthodontics, The Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing, China.

Orthodontic tooth movement (OTM) is induced by biomechanical stimuli and facilitated by periodontal tissue remodeling, where multiple immune cells participate in this progression. It has been demonstrated that macrophage is essential for mechanical force-induced tissue remodeling. In this study, we first found that mechanical force significantly induced macrophage proliferation in human periodontal samples and murine OTM models. Yet, how macrophages perceive mechanical stimuli and thereby modulate their biological behaviors remain elusive. To illustrate the mechanisms of mechanical force-induced macrophage proliferation, we subsequently identified Piezo1, a novel mechanosensory ion channel, to modulate macrophage response subjected to mechanical stimuli. Mechanical force upregulates Piezo1 expression in periodontal tissues and cultured bone-marrow-derived macrophages (BMDMs). Remarkably, suppressing Piezo1 with GsMTx4 retarded OTM through reduced macrophage proliferation. Moreover, knockdown of Piezo1 effectively inhibited mechanical force-induced BMDMs proliferation. RNA sequencing was further performed to dissect the underlying mechanisms of Piezo1-mediated mechanotransduction utilizing mechanical stretch system. We revealed that Piezo1-activated AKT/GSK3β signaling was closely associated with macrophage proliferation upon mechanical stimuli. Importantly, Cyclin D1 (Ccnd1) was authenticated as a critical downstream factor of Piezo1 that facilitated proliferation by enhancing Rb phosphorylation. We generated genetically modified mice in which Ccnd1 could be deleted in macrophages in an inducible manner. Conditional ablation of Ccnd1 inhibited periodontal macrophage proliferation and therefore delayed OTM. Overall, our findings highlight that proliferation driven by mechanical force is a key process by which macrophages infiltrate in periodontal tissue during OTM, where Piezo1-AKT-Ccnd1 axis plays a pivotal role.
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http://dx.doi.org/10.1096/fj.202200314RDOI Listing
August 2022

One-Month Outcomes of Intravitreal Anti-VEGF vs. Dexamethasone Implant in the Treatment of Diabetic Macular Edema in Vitrectomized Eyes.

Front Med (Lausanne) 2022 14;9:895220. Epub 2022 Jun 14.

Department of Ophthalmology, The Second Xiangya Hospital, Central South University, Changsha, China.

Objectives: To compare short-term effect of intravitreal ranibizumab with dexamethasone implant for diabetic macular edema (DME) in vitrectomized eyes.

Methods: Single-center, prospective, randomized study of vitrectomized eyes with DME. Study eyes were divided into two groups, receiving ranibizumab (IVV group, = 35 eyes) or dexamethasone implant (IVD group, = 35 eyes) respectively. Patients were evaluated at baseline, Week 1 and Month 1. The main outcome measures included best-corrected visual acuity (BCVA), central retinal thickness (CRT) and intraocular pressure (IOP).

Results: BCVA and CRT were similar in the two groups at baseline. At Week 1, the CRT improvement was significant in two groups ( = 0.041 in IVV group, = 0.030 in IVD group), but at Month 1, only IVD group had significant improvement in CRT ( < 0.001). And BCVA gains were significant at Week 1 ( = 0.029) and Month 1 ( = 0.001) in IVD group, whereas IVV group did not show significant BCVA gains ( = 0.056 at Week1, = 0.166 at Month 1). The changes of BCVA and CRT were significantly higher in IVD group than IVV group at Month1, but the changes were not significant at Week1.

Conclusions: Comparing to anti-VEGF therapy, DEX implant is more effect in improving BCVA and reducing CRT in vitrectomized eyes at 1 month, which indicated DEX implant is a better strategy.
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http://dx.doi.org/10.3389/fmed.2022.895220DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9237330PMC
June 2022

Identification of potential matrix metalloproteinase-2 inhibitors from natural products through advanced machine learning-based cheminformatics approaches.

Mol Divers 2022 Jun 30. Epub 2022 Jun 30.

Shandong University of Traditional Chinese Medicine, Jinan, 250355, China.

Matrix metalloproteinase-2 (MMP-2) is capable of degrading Collage TypeIV in the vascular basement membrane and extracellular matrix. Studies have shown that MMP-2 is tightly associated with the biological behavior of malignant tumors. Therefore, the identification of inhibitors targeting MMP-2 could be effective in treating the disease by maintaining extracellular matrix homeostasis. In the pharmaceutical and biomedical fields, many computational tools are widely used, which improve the efficiency of the whole process to some extent. Apart from the conventional cheminformatics approaches (e.g., pharmacophore model and molecular docking), virtual screening strategies based on machine learning also have promising applications. In this study, we collected 2871 compound activity data against MMP-2 from the ChEMBL database and divided the training and test sets in a 3:1 ratio. Four machine learning algorithms were then selected to construct the classification models, and the best-performing model, i.e., the stacking-based fusion model with the highest AUC value in both training and test datasets, was used for the virtual screening of ZINC database. Next, we screened 17 potential MMP-2 inhibitors from the results predicted by the machine learning model via ADME/T analysis. The interactions between these compounds and the target protein were explored through molecular docking calculations, and the results showed that ZINC712249, ZINC4270723, and ZINC15858504 had lower binding free energies than the co-crystal ligand. To further examine the binding stability of the complexes, we performed molecular dynamics simulations and finally identified these three hits as the most promising natural products for MMP-2 inhibitors.
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http://dx.doi.org/10.1007/s11030-022-10467-9DOI Listing
June 2022

SAST-GCN: Segmentation Adaptive Spatial Temporal-Graph Convolutional Network for P3-Based Video Target Detection.

Front Neurosci 2022 2;16:913027. Epub 2022 Jun 2.

Henan Key Laboratory of Imaging and Intelligent Processing, People's Liberation Army of China (PLA) Strategic Support Force Information Engineering University, Zhengzhou, China.

Detecting video-induced P3 is crucial to building the video target detection system based on the brain-computer interface. However, studies have shown that the brain response patterns corresponding to video-induced P3 are dynamic and determined by the interaction of multiple brain regions. This paper proposes a segmentation adaptive spatial-temporal graph convolutional network (SAST-GCN) for P3-based video target detection. To make full use of the dynamic characteristics of the P3 signal data, the data is segmented according to the processing stages of the video-induced P3, and the brain network connections are constructed correspondingly. Then, the spatial-temporal feature of EEG data is extracted by adaptive spatial-temporal graph convolution to discriminate the target and non-target in the video. Especially, a style-based recalibration module is added to select feature maps with higher contributions and increase the feature extraction ability of the network. The experimental results demonstrate the superiority of our proposed model over the baseline methods. Also, the ablation experiments indicate that the segmentation of data to construct the brain connection can effectively improve the recognition performance by reflecting the dynamic connection relationship between EEG channels more accurately.
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http://dx.doi.org/10.3389/fnins.2022.913027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9201684PMC
June 2022

Fecal Microbiota Transplantation for Patients With Irritable Bowel Syndrome: A Meta-Analysis of Randomized Controlled Trials.

Front Nutr 2022 27;9:890357. Epub 2022 May 27.

Department of Gastroenterology and Hepatology, The First Medical Center, Chinese PLA General Hospital, Beijing, China.

Background: Gut microbiota has been identified as an imbalance in patients with irritable bowel syndrome (IBS). Fecal microbiota transplantation (FMT) is a novel method to restore microbiota and treat IBS patients.

Objective: To conduct a meta-analysis and estimate the efficacy and safety of FMT for the treatment of IBS patients with subgroup analyses to explore the most effective way of FMT for IBS.

Methods: All eligible studies were searched from PubMed, Embase, Web of Science, and the Cochrane Library through multiple search strategies. Data were extracted from studies comprising the following criteria: double-blind, randomized controlled trials (RCTs) that compared the efficacy of FMT with placebo for adult patients (≥18 years old) with IBS. A meta-analysis was performed to evaluate the summary relative risk (RR) and 95% confidence intervals (CIs).

Results: A total of seven RCTs comprising 489 subjects were eligible for this meta-analysis. Pooled data showed no significant improvement of global IBS symptoms in patients with FMT compared with placebo (RR = 1.34; 95% CI 0.75-2.41, = 0.32). A significant heterogeneity was observed among the studies ( = 83%, < 0.00001). There was no significant evidence of funnel plot asymmetry (Egger's test, = 0.719; Begg's test, = 1.000), indicating no existence of publication bias. Subgroup analyses revealed that FMT operated by invasive routes, including gastroscope, colonoscope, and nasojejunal tube, significantly improved global IBS symptoms (RR = 1.96; 95% CI 1.23-3.11, = 0.004) with heterogeneity ( = 57%, = 0.06) and an NNT of 3 (95% CI 2-14). However, FMT delivered oral capsules showed a negative impact on patients with IBS (RR = 0.56; 95% CI 0.33-0.96, = 0.03) with a low heterogeneity ( = 39%, = 0.2) and an NNH of 3 (95% CI 2-37).

Conclusion: The current evidence from RCTs with all routes of FMT does not show significant global improvement in patients with IBS. However, FMT operated by invasive routes significantly improved global IBS symptoms.
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http://dx.doi.org/10.3389/fnut.2022.890357DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9202577PMC
May 2022

Efficacy of endoscopic anterior fundoplication with a novel ultrasonic surgical endostapler for gastroesophageal reflux disease: Six-month results from a multicenter prospective trial.

Endosc Ultrasound 2022 Jun 8. Epub 2022 Jun 8.

Department of Gastroenterology and Hepatology, The First Medical Center, Chinese PLA General Hospital, Beijing, China.

Background And Objectives: Endoscopic therapy is an option for the treatment of refractory gastroesophageal reflux disease (GERD). We aimed to evaluate the efficacy and safety of transoral incisionless fundoplication with the Medigus ultrasonic surgical endostapler (MUSE™) for refractory GERD.

Materials And Methods: Patients with 2 years of documented GERD symptoms and at least 6 months of proton-pump inhibitors (PPIs) therapy were enrolled in four medical centers from March 2017 to March 2019. The GERD health-related quality of life (HRQL) score, GERD questionnaire score, total acid exposure on esophageal pH probe monitoring, the gastroesophageal flap valve (GEFV), esophageal manometry, and PPIs dosage were compared between the pre- and post-MUSE procedure. All of the side effects were recorded.

Results: A reduction of at least 50% in the GERD-HRQL score was observed in 77.8% (42/54) patients. Most patients 74.1% (40/54) discontinued PPIs and 11.1% (6/54) reported a ≥50% dose reduction. The percentage of patients who had normalized acid exposure time after the procedure was 46.9% (23/49). The existence of hiatal hernia at baseline was negatively correlated with the curative effect. Mild pain was common and resolved within 48 h postprocedure. Serious complications were pneumoperitoneum (one case), mediastinal emphysema combined with pleural effusion (two cases).

Conclusions: Endoscopic anterior fundoplication with MUSE was an effective treatment for refractory GERD, but still needs refinement and improvement in safety aspect. Esophageal hiatal hernia may affect the efficacy of MUSE. (www.chictr.org.cn, ChiCTR2000034350).
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http://dx.doi.org/10.4103/EUS-D-21-00244DOI Listing
June 2022

Toll-like receptor 9 (TLR9) gene deletion-mediated fracture healing in type II diabetic osteoporosis associates with inhibition of the nuclear factor-kappa B (NF-κB) signaling pathway.

Bioengineered 2022 05;13(5):13689-13702

Pathology Diagnosis Center, The HongQi Hospital, The First Clinical Medical School of Mudanjiang Medical College, Mudanjiang, PR, China.

Diabetes is characterized by increased fracture risk. Evidence from studies is lacking for anti-fracture strategies in diabetes. Our microarray analyses predicted association of Toll-like receptor 9 (TLR9) with both diabetes and osteoporosis, which was the focus of this work in a murine model of type II diabetic osteoporosis (T2DOP). A T2DOP model with fracture was established in TLR9 knockout (TLR9) mice, which were then treated with the NF-κB signaling pathway inhibitor (PDTC) and activator (TNF-α). The obtained data suggested that TLR9 knockout augmented regeneration of bone tissues and cartilage area in the callus, and diminished fibrous tissues in T2DOP mice. Moreover, TLR9 depletion significantly affected bone mineral density (BMD), bone volume/tissue volume (BV/TV), connectivity density, trabecular number, trabecular separation and trabecular thickness, thus promoting fracture recovery. Bone morphology and structure were also improved in response to TLR9 depletion in T2DOP mice. TLR9 depletion inactivated NF-κB signaling in T2DOP mice. PDTC was found to enhance fracture healing in T2DOP mice, while TNF-α negated this effect. Collectively, these data indicate that TLR9 depletion may hold anti-fracture properties, making it a potential therapeutic target for T2DOP. Diabetic osteoporosis (DOP); bone mineral density (BMD); Toll-like receptors (TLRs); type 2 diabetes (T2D); Toll-like receptor 9 (TLR9); nuclear factor-kappaB (NF-κB); streptozotocin (STZ); type 2 diabetic osteoporosis (T2DOP); Gene Expression Omnibus (GEO); Kyoto encyclopedia of genes and genomes (KEGG); pyrrolidine dithiocarbamate (PDTC); computed tomography (CT); Hematoxylin-eosin (HE); bone morphogenetic protein 7 (BMP7); analysis of variance (ANOVA).
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http://dx.doi.org/10.1080/21655979.2022.2063663DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9275877PMC
May 2022

Flocculation of Chlorella vulgaris-induced algal blooms: critical conditions and mechanisms.

Environ Sci Pollut Res Int 2022 Jun 14. Epub 2022 Jun 14.

College of Eco-Environmental Engineering, Guizhou Minzu University, Guiyang, 550025, China.

Algal blooms have posed great threats to livestocks and human health. Although flocculation is effective, its efficiency may hinder the direct application for algal blooms. In this study, critical (optimal) conditions and mechanisms for AlCl, FeCl, poly-aluminum chloride (PAC), chitosan, and polydimethyldiallylammonium chloride (PDADMAC)-induced flocculation of Chlorella vulgaris (C. vulgaris) were studied. Results identified the critical conditions which can cause flocculation efficiencies over 90% in 45 min for the five flocculants. Specifically, 4~10-mg/L doses of PDADMAC were proved to be appropriate for the treatment of C. vulgaris-induced algal blooms at pH 6.0~12.0. To probe the underlying mechanisms, functional groups involved in flocculation, zeta potential, and species distribution were analyzed during flocculation. FT-IR results indicated that N-H stretching in amine and C-H deformation in aliphatics were involved in algal flocculation with FeCl, and C-H deformation played an important role with PDADMAC, PAC, and chitosan. For AlCl, zeta potential and species distribution results suggested that charge neutralization and adsorption bridging were responsible for algal flocculation at pH 6~8. However, adsorption bridging and sweeping effects were the main mechanisms at pH >3 for FeCl. The flocculation mechanisms for the rest of the three polymers were charge neutralization, adsorption bridging, and sweeping. Meanwhile, all the flocculation processes followed second-order kinetics. Strong linkages were found between the rate constant, fractal dimension, and flocculation efficiency (P < 0.05). The results of critical flocculation conditions and mechanisms indicated that PDADMAC was an excellent flocculant for C. vulgaris removing and recycling, especially in water bloom treatment.
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http://dx.doi.org/10.1007/s11356-022-21383-8DOI Listing
June 2022

Exploring the Immune Infiltration Landscape and M2 Macrophage-Related Biomarkers of Proliferative Diabetic Retinopathy.

Front Endocrinol (Lausanne) 2022 27;13:841813. Epub 2022 May 27.

Department of Ophthalmology, The Second Xiangya Hospital, Central South University, Changsha, China.

Backgrounds: Diabetic retinopathy (DR), especially proliferative diabetic retinopathy (PDR), is the major cause of irreversible blindness in the working-age population. Increasing evidence indicates that immune cells and the inflammatory microenvironment play an important role during PDR development. Herein, we aim to explore the immune landscape of PDR and then identify potential biomarkers correlated with specific infiltrating immune cells.

Methods: We mined and re-analyzed PDR-related datasets from the Gene Expression Omnibus (GEO) database. Using the cell-type identification by estimating relative subsets of RNA transcripts (CIBERSORT) algorithm, we investigated the infiltration of 22 types of immune cells in all selected samples; analyses of differences and correlations between infiltrating cells were used to reveal the immune landscape of PDR. Thereafter, weighted gene co-expression network analysis (WGCNA) and differential expression analysis were applied to identify the hub genes on M2 macrophages that may affect PDR progression.

Results: Significant differences were found between infiltration levels of immune cells in fibrovascular membranes (FVMs) from PDR and normal retinas. The percentages of follicular helper T cells, M1 macrophages, and M2 macrophages were increased significantly in FVMs. Integrative analysis combining the differential expression and co-expression revealed the M2 macrophage-related hub genes in PDR. Among these, , and showed increased expression in FVM and may be potential biomarkers for PDR.

Conclusions: Our findings provide novel insights into the immune mechanisms involved in PDR. , and are M2 macrophage-related biomarkers, further study of these genes could inform novel ideas and basis for the understanding of disease progression and targeted treatment of PDR.
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http://dx.doi.org/10.3389/fendo.2022.841813DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9186015PMC
May 2022

Solution-processed Ge(ii)-based chalcogenide thin films with tunable bandgaps for photovoltaics.

Chem Sci 2022 May 25;13(20):5944-5950. Epub 2022 Apr 25.

Beijing National Laboratory for Molecular Sciences (BNLMS), CAS Key Laboratory of Molecular Nanostructure and Nanotechnology, Institute of Chemistry, Chinese Academy of Sciences Beijing 100190 China

Solution processes have been widely used to construct chalcogenide-based thin-film optoelectronic and electronic devices that combine high performance with low-cost manufacturing. However, Ge(ii)-based chalcogenide thin films possessing great potential for optoelectronic devices have not been reported using solution-based processes; this is mainly attributed to the easy oxidation of intermediate Ge(ii) to Ge(iv) in the precursor solution. Here we report solution-processed deposition of Ge(ii)-based chalcogenide thin films in the case of GeSe and GeS films by introducing hypophosphorous acid as a suitable reducing agent and strong acid. This enables the generation of Ge(ii) from low-cost and stable GeO powders while suppressing the oxidation of Ge(ii) to Ge(iv) in the precursor solution. We further show that such solution processes can also be used to deposit GeSe S alloy films with continuously tunable bandgaps ranging from 1.71 eV (GeS) to 1.14 eV (GeSe) by adjusting the atomic ratio of S- to Se-precursors in solution, thus allowing the realization of optimal-bandgap single-junction photovoltaic devices and multi-junction devices.
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http://dx.doi.org/10.1039/d1sc07043fDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9132017PMC
May 2022

Correlation between the fatty infiltration of paraspinal muscles and disc degeneration and the underlying mechanism.

BMC Musculoskelet Disord 2022 May 30;23(1):509. Epub 2022 May 30.

Department of Orthopedics, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, 197 Ruijin Er Road, Shanghai, 200025, China.

Background: Low back pain (LBP) is associated with lumbar disc degeneration (LDD) and fatty infiltration of paraspinal muscles. However, there are some controversies about the relationship between LDD and fatty infiltration of paraspinal muscles, and the causation of them is also not clear. Thus, we investigated whether the degree of LDD was associated with fatty infiltration of paraspinal muscles and preliminarily explored the underlying mechanism.

Methods: A retrospective study was conducted on 109 patients with chronic LBP. The degree of LDD was assessed by the Pfirrmann classification. Total muscle cross-sectional area, L4 vertebral body endplate area, and fat cross-sectional area at axial T2-weighted MRI were measured. Multifidus and lumbar disc specimens were taken from eight individuals undergoing discectomy for disc herniation. Gene and protein expression levels of TNF were quantified through qPCR assays and ELISA, respectively.

Results: The relative cross-sectional area, total muscle cross-sectional area, and muscle cross-sectional area asymmetry were not related to LDD. Pfirrmann grades correlated strongly with fatty infiltration of the multifidus and moderately with fatty infiltration of the erector spinae and the psoas muscles. Linear regression analysis suggested that Pfirrmann grades were most associated with fatty infiltration of the multifidus. Compared with II-degree degeneration discs (mild-degeneration group), fatty infiltration of the multifidus in IV-degree degeneration discs (severe-degeneration group) significantly increased, accompanied by increased mRNA expression of TNF. Meanwhile, the protein expression levels of TNF (pg/g protein) in discs (16.62 ± 4.33) and multifidus (13.10 ± 2.76) of the severe-degeneration group were higher than those in the mild-degeneration group (disc: 9.75 ± 2.18; multifidus: 7.84 ± 2.43). However, the mRNA expression of TNF in the multifidus was not significantly different between the two groups.

Conclusions: The results suggest that LDD is associated with fatty infiltration of the multifidus. The possible underlying mechanism is that LDD induces fatty infiltration by inflammation. Furthermore, compared with the erector spinae and the psoas muscles, fatty infiltration of the multifidus shows an optimal correlation with LDD, which may contribute to further understanding of LDD pathology.
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http://dx.doi.org/10.1186/s12891-022-05466-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9150320PMC
May 2022

The role of cell-penetrating peptides in potential anti-cancer therapy.

Clin Transl Med 2022 05;12(5):e822

The Key Laboratory of Model Animal and Stem Cell Biology in Hunan Province, Hunan Normal University, Changsha, Hunan, China.

Due to the complex physiological structure, microenvironment and multiple physiological barriers, traditional anti-cancer drugs are severely restricted from reaching the tumour site. Cell-penetrating peptides (CPPs) are typically made up of 5-30 amino acids, and can be utilised as molecular transporters to facilitate the passage of therapeutic drugs across physiological barriers. Up to now, CPPs have widely been used in many anti-cancer treatment strategies, serving as an excellent potential choice for oncology treatment. However, their drawbacks, such as the lack of cell specificity, short duration of action, poor stability in vivo, compatibility problems (i.e. immunogenicity), poor therapeutic efficacy and formation of unwanted metabolites, have limited their further application in cancer treatment. The cellular uptake mechanisms of CPPs involve mainly endocytosis and direct penetration, but still remain highly controversial in academia. The CPPs-based drug delivery strategy could be improved by clever design or chemical modifications to develop the next-generation CPPs with enhanced cell penetration capability, stability and selectivity. In addition, some recent advances in targeted cell penetration that involve CPPs provide some new ideas to optimise CPPs.
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http://dx.doi.org/10.1002/ctm2.822DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9121317PMC
May 2022

The Efficacy of Acupuncture on Patients with Erectile Dysfunction: A Review.

Evid Based Complement Alternat Med 2022 9;2022:4807271. Epub 2022 May 9.

Department of Andrology, Xiyuan Hospital of China Academy of Chinese Medical Sciences, 1 Caochang, Xiyuan, Beijing 100091, China.

Erectile dysfunction (ED) is one of the most common sexual dysfunctions in men. The prevalence of ED has been increasing in recent years, which has critically affected male reproductive health and quality of life. According to various guidelines, phosphodiesterase-5 inhibitors are the most commonly recommended drugs for treating ED. However, many patients turn to alternative therapies because of adverse reactions, such as headache, and the poor efficacy of these drugs. Acupuncture is a long-established treatment in traditional Chinese medicine (TCM) and has been approved by the World Health Organization for improving penile erection as well as other discomforts in patients. However, previous systematic reviews have not discussed the characteristics and the related mechanisms of acupuncture treatment. Therefore, this study focuses on summarizing the characteristics and advantages of TCM in acupuncture treatment for ED based on relevant literature and on predicting and analyzing the related mechanisms.
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http://dx.doi.org/10.1155/2022/4807271DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9110168PMC
May 2022

Investigating the multi-target therapeutic mechanism of Guihuang formula on Chronic Prostatitis.

J Ethnopharmacol 2022 Aug 14;294:115386. Epub 2022 May 14.

Xiyuan Hospital of China Academy of Chinese Medical Sciences, Beijing, China. Electronic address:

Ethnopharmacological Relevance: Chronic prostatitis (CP) is a complex, intractable and prevalent urological disorder in men with no effective treatment. Guihuang formula (GHF) is a traditional Chinese medicine compound that is advantageous as a CP treatment, but its aetiology is poorly understood. Research and exploration of the mechanism of GHF will help the development of a potentially valuable drug for CP and provide deeper insight into CP.

Aim Of The Study: To examine and further clarify the multi-target therapeutic mechanism of GHF on CP.

Materials And Methods: The chemical components in GHF were identified using UPLC-Q/TOF-MS. The active components and potential targets of GHF for the treatment of CP were screened and analyzed using network pharmacology and molecular docking. We constructed a CP rat model to investigate the therapeutic effect of GHF on CP and verify the influence of key targets and core pathways based on the results of network pharmacology.

Results: A total of 143 ingredients were identified in GHF using UPLC-Q/TOF-MS, and 111 potential targets for GHF of CP were predicted. The "drug-ingredient-target-pathway" network was constructed and in compliance with the "Jun-Chen-Zuo-Shi" principle. GHF significantly reduced the prostate index, alleviated histological damage in the prostate, decreased CD3 T cells and CD45 leukocyte infiltration in the prostate, downregulated the expression of the proinflammatory cytokines IL-1β, IL-6, IL-18, COX-2, MCP-1 and TNF-α, decreased ROS levels and alleviated the production of MDA accompanied by an increase of SOD and GSH-PX levels. Meanwhile, GHF suppressed apoptosis in macrophages, downregulated the mRNA levels of PI3K, AKT and P65 NF-κB and inhibited the phosphorylation of the PI3K, AKT and P65 NF-κB.

Conclusion: A network pharmacology and experimental validation-based strategy was used to elucidate the underlying "multicomponent, multitarget, and multipathway" mode of action of GHF against CP. We verified that GHF inhibited oxidative stress and inflammatory response, suppressed apoptosis in macrophages, inhibited the activation of the inflammation-related PI3K/AKT/NF-κB pathway in CP rat. These findings extend the conventional views of "one drug hits one target", and offer novel insights and indication paradigm for the future discovery on the multi-target therapeutic mechanism of traditional Chinese medicine compound.
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http://dx.doi.org/10.1016/j.jep.2022.115386DOI Listing
August 2022

The Association between Migraine and Fetal-Type Posterior Cerebral Artery in Patients with Ischemic Stroke.

Cerebrovasc Dis 2022 May 13:1-7. Epub 2022 May 13.

Department of Neurology, Jinling Hospital, The First School of Clinical Medicine, Southern Medical University, Nanjing, China.

Objective: The aim of the study was to determine if migraine is associated with fetal-type posterior cerebral artery (PCA) in patients with ischemic stroke.

Method: In this cross-sectional study, patients with acute ischemic stroke were enrolled from two hospitals. The history of migraine headache was evaluated during a face-to-face interview. The variants of fetal-type PCA were assessed with MRA, CTA, or DSA. Patients with and without migraine were compared in terms of fetal-type PCA status and other clinic characteristics. Multivariate logistic regression analyses were performed to adjust for confounders and provide risk estimates for observed associations.

Result: In 750 patients qualified for analysis, 85 (11.3%) were determined with migraine. Patients with migraine had a higher proportion of female gender (51.8% vs. 31.0%, p < 0.001), hypertension (72.9% vs. 57.7%, p = 0.007), and fetal-type PCA (36.5% vs. 20.1%, p = 0.001), while lower proportion of current smoking (25.9% vs. 38.3%, p = 0.025) than patients without migraine. National Institutes of Health Stroke Scale (NIHSS) score (3 vs. 2, p = 0.016) was also higher in migraineurs than in non-migraineurs. After adjustment for confounders, fetal-type PCA status was independently associated with migraine (odds ratio [OR] = 2.06; 95% confidence interval [CI], 1.25-3.38; p = 0.005). Other factors associated to migraine included female gender (OR = 2.03; 95% CI, 1.13-3.62; p = 0.017), hypertension (OR = 1.97; 95% CI, 1.17-3.34; p = 0.011), and NIHSS score (OR = 1.08; 95% CI, 1.01-1.16; p = 0.018).

Conclusion: Migraine was associated with fetal-type PCA in patients with ischemic stroke. This finding supported the hypothesis that vascular mechanisms get involved in the migraine-stroke association.
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http://dx.doi.org/10.1159/000524616DOI Listing
May 2022

An Assessment of China's Digital Trade Development and Influencing Factors.

Front Psychol 2022 26;13:837885. Epub 2022 Apr 26.

College of Science and Technology, Ningbo University, Cixi, China.

The pattern and scale of commerce worldwide have been greatly transformed by the Fourth Industrial Revolution and technological advancement; digital trade has become the primary form of trade in the digital economy. On the basis of information network infrastructure, information technology level, digital industrialization level, and industrial digitalization level, this study establishes a comprehensive assessment system that applies an entropy-TOPSIS model to evaluate digital trade development level in China. The results indicate that digital trade in China was steadily growing between 2010 and 2019. A principal component analysis is conducted to identify factors affecting the digital trade development level in China. The analysis results suggest that Internet development, population income, industrial structure, payment convenience level, fixed asset investment, online transaction scale, and economic development all have positive effects on the digital trade development level in China, with payment convenience level having the greatest influence. By contrast, state intervention and degree of dependence on foreign trade have a negative effect on digital trade development.
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http://dx.doi.org/10.3389/fpsyg.2022.837885DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9087175PMC
April 2022

CBX7 represses the POU2F2 to inhibit the PD-L1 expression and regulate the immune response in bladder cancer.

Biochem Biophys Res Commun 2022 07 28;613:12-18. Epub 2022 Apr 28.

Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. Electronic address:

Bladder cancer (BC) is one of the most common malignant tumors of the urinary system worldwide. To date, immune checkpoint inhibitors (including PD-1/PD-L1) have been applied to treat patients with bladder cancer in the clinic and achieved the promising outcome. Further improvement of the anticancer efficiency of these immune therapies is crucial for bladder cancer. Our previous RNA-seq data on CBX7 (GSE185630) suggested that CBX7 might repress PD-L1 expression and PD-1 checkpoint pathway in cancer. In this study, we revealed that CBX7 downregulated the expression of POU2F2 that indirectly repressed the PD-L1 in BC cells. Depletion of CBX7 resulted in resistance to PD-1 blockade in bladder cancer. Collectively, our results suggested that the CBX7/POU2F2/PD-L1 axis plays an important role in determining the antitumor effect of PD-1 blockade in bladder cancer.
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http://dx.doi.org/10.1016/j.bbrc.2022.04.114DOI Listing
July 2022
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