Bin Tean Teh

Bin Tean Teh

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TSA-CRAFT: A Free Software for Automatic and Robust Thermal Shift Assay Data Analysis.

SLAS Discov 2019 Jun 11;24(5):606-612. Epub 2019 Feb 11.

1 Cancer Science Institute of Singapore, National University of Singapore, Singapore.

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http://dx.doi.org/10.1177/2472555218823547DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6537141PMC
June 2019

Genomic and Transcriptomic Profiling of Combined Hepatocellular and Intrahepatic Cholangiocarcinoma Reveals Distinct Molecular Subtypes.

Cancer Cell 2019 Jun 23;35(6):932-947.e8. Epub 2019 May 23.

Biomedical Pioneering Innovation Center (BIOPIC) and Translational Cancer Research Center, School of Life Sciences, First Hospital, Peking University, Beijing 100871, China; Laboratory of Cancer Cell Biology, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2019.04.007DOI Listing
June 2019

The importance of including diverse populations in cancer genomic and epigenomic studies.

Authors:
Bin Tean Teh

Nat Rev Cancer 2019 Jun 3. Epub 2019 Jun 3.

National Cancer Centre, Singapore, Singapore.

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http://dx.doi.org/10.1038/s41568-019-0158-0DOI Listing
June 2019

Sex specific associations in genome wide association analysis of renal cell carcinoma.

Authors:
Ruhina S Laskar David C Muller Peng Li Mitchell J Machiela Yuanqing Ye Valerie Gaborieau Matthieu Foll Jonathan N Hofmann Leandro Colli Joshua N Sampson Zhaoming Wang Delphine Bacq-Daian Anne Boland Behnoush Abedi-Ardekani Geoffroy Durand Florence Le Calvez-Kelm Nivonirina Robinot Helene Blanche Egor Prokhortchouk Konstantin G Skryabin Laurie Burdett Meredith Yeager Sanja Radojevic-Skodric Slavisa Savic Lenka Foretova Ivana Holcatova Vladimir Janout Dana Mates Stefan Rascu Anush Mukeria David Zaridze Vladimir Bencko Cezary Cybulski Eleonora Fabianova Viorel Jinga Jolanta Lissowska Jan Lubinski Marie Navratilova Peter Rudnai Beata Świątkowska Simone Benhamou Geraldine Cancel-Tassin Olivier Cussenot Antonia Trichopoulou Elio Riboli Kim Overvad Salvatore Panico Borje Ljungberg Raviprakash T Sitaram Graham G Giles Roger L Milne Gianluca Severi Fiona Bruinsma Tony Fletcher Kvetoslava Koppova Susanna C Larsson Alicja Wolk Rosamonde E Banks Peter J Selby Douglas F Easton Paul Pharoah Gabriella Andreotti Laura E Beane Freeman Stella Koutros Demetrius Albanes Satu Männistö Stephanie Weinstein Peter E Clark Todd L Edwards Loren Lipworth Hallie Carol Matthew L Freedman Mark M Pomerantz Eunyoung Cho Peter Kraft Mark A Preston Kathryn M Wilson J Michael Gaziano Howard D Sesso Amanda Black Neal D Freedman Wen-Yi Huang John G Anema Richard J Kahnoski Brian R Lane Sabrina L Noyes David Petillo Bin Tean Teh Ulrike Peters Emily White Garnet L Anderson Lisa Johnson Juhua Luo Wong-Ho Chow Lee E Moore Toni K Choueiri Christopher Wood Mattias Johansson James D McKay Kevin M Brown Nathaniel Rothman Mark G Lathrop Jean-Francois Deleuze Xifeng Wu Paul Brennan Stephen J Chanock Mark P Purdue Ghislaine Scelo

Eur J Hum Genet 2019 Jun 23. Epub 2019 Jun 23.

International Agency for Research on Cancer (IARC), Lyon, France.

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http://dx.doi.org/10.1038/s41431-019-0455-9DOI Listing
June 2019

Assessment of different strategies for scalable production and proliferation of human myoblasts.

Cell Prolif 2019 May 19;52(3):e12602. Epub 2019 Mar 19.

State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.

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http://dx.doi.org/10.1111/cpr.12602DOI Listing
May 2019

Genomic profile of breast sarcomas: a comparison with malignant phyllodes tumours.

Breast Cancer Res Treat 2019 Apr 3;174(2):365-373. Epub 2018 Dec 3.

Division of Pathology, Singapore General Hospital, Level 7, Diagnostics Tower, Academia, 20 College Road, Singapore, 169856, Singapore.

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http://dx.doi.org/10.1007/s10549-018-5067-5DOI Listing
April 2019

Somatic mutations of PREX2 gene in patients with hepatocellular carcinoma.

Sci Rep 2019 Feb 22;9(1):2552. Epub 2019 Feb 22.

Center for Infectious Disease and Cancer Research (CICAR), Kaohsiung Medical University, Kaohsiung, 80708, Taiwan.

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http://dx.doi.org/10.1038/s41598-018-36810-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385191PMC
February 2019

The influence of obesity-related factors in the etiology of renal cell carcinoma-A mendelian randomization study.

Authors:
Mattias Johansson Robert Carreras-Torres Ghislaine Scelo Mark P Purdue Daniela Mariosa David C Muller Nicolas J Timpson Philip C Haycock Kevin M Brown Zhaoming Wang Yuanqing Ye Jonathan N Hofmann Matthieu Foll Valerie Gaborieau Mitchell J Machiela Leandro M Colli Peng Li Jean-Guillaume Garnier Helene Blanche Anne Boland Laurie Burdette Egor Prokhortchouk Konstantin G Skryabin Meredith Yeager Sanja Radojevic-Skodric Simona Ognjanovic Lenka Foretova Ivana Holcatova Vladimir Janout Dana Mates Anush Mukeriya Stefan Rascu David Zaridze Vladimir Bencko Cezary Cybulski Eleonora Fabianova Viorel Jinga Jolanta Lissowska Jan Lubinski Marie Navratilova Peter Rudnai Simone Benhamou Geraldine Cancel-Tassin Olivier Cussenot Elisabete Weiderpass Börje Ljungberg Raviprakash Tumkur Sitaram Christel Häggström Fiona Bruinsma Susan J Jordan Gianluca Severi Ingrid Winship Kristian Hveem Lars J Vatten Tony Fletcher Susanna C Larsson Alicja Wolk Rosamonde E Banks Peter J Selby Douglas F Easton Gabriella Andreotti Laura E Beane Freeman Stella Koutros Satu Männistö Stephanie Weinstein Peter E Clark Todd L Edwards Loren Lipworth Susan M Gapstur Victoria L Stevens Hallie Carol Matthew L Freedman Mark M Pomerantz Eunyoung Cho Kathryn M Wilson J Michael Gaziano Howard D Sesso Neal D Freedman Alexander S Parker Jeanette E Eckel-Passow Wen-Yi Huang Richard J Kahnoski Brian R Lane Sabrina L Noyes David Petillo Bin Tean Teh Ulrike Peters Emily White Garnet L Anderson Lisa Johnson Juhua Luo Julie Buring I-Min Lee Wong-Ho Chow Lee E Moore Timothy Eisen Marc Henrion James Larkin Poulami Barman Bradley C Leibovich Toni K Choueiri G Mark Lathrop Jean-Francois Deleuze Marc Gunter James D McKay Xifeng Wu Richard S Houlston Stephen J Chanock Caroline Relton J Brent Richards Richard M Martin George Davey Smith Paul Brennan

PLoS Med 2019 01 3;16(1):e1002724. Epub 2019 Jan 3.

International Agency for Research on Cancer (IARC), Lyon, France.

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http://dx.doi.org/10.1371/journal.pmed.1002724DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317776PMC
January 2019

Transcriptional analysis of immune genes in Epstein-Barr virus-associated gastric cancer and association with clinical outcomes.

Gastric Cancer 2018 11 18;21(6):1064-1070. Epub 2018 Jun 18.

Cancer and Stem Cell Biology Program, Duke-NUS Medical School, 8 College Road, Singapore, 169857, Singapore.

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http://link.springer.com/10.1007/s10120-018-0851-9
Publisher Site
http://dx.doi.org/10.1007/s10120-018-0851-9DOI Listing
November 2018

Molecular insights into paediatric breast fibroepithelial tumours.

Histopathology 2018 Nov 22;73(5):809-818. Epub 2018 Aug 22.

Division of Pathology, Singapore General Hospital, Singapore.

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http://dx.doi.org/10.1111/his.13701DOI Listing
November 2018

Corrigendum re "Genetic Variants Related to Longer Telomere Length are Associated with Increased Risk of Renal Cell Carcinoma" [Eur Urol 2017;72:747-54].

Authors:
Mitchell J Machiela Jonathan N Hofmann Robert Carreras-Torres Kevin M Brown Mattias Johansson Zhaoming Wang Matthieu Foll Peng Li Nathaniel Rothman Sharon A Savage Valerie Gaborieau James D McKay Yuanqing Ye Marc Henrion Fiona Bruinsma Susan Jordan Gianluca Severi Kristian Hveem Lars J Vatten Tony Fletcher Kvetoslava Koppova Susanna C Larsson Alicja Wolk Rosamonde E Banks Peter J Selby Douglas F Easton Paul Pharoah Gabriella Andreotti Laura E Beane Freeman Stella Koutros Demetrius Albanes Satu Mannisto Stephanie Weinstein Peter E Clark Todd E Edwards Loren Lipworth Susan M Gapstur Victoria L Stevens Hallie Carol Matthew L Freedman Mark M Pomerantz Eunyoung Cho Peter Kraft Mark A Preston Kathryn M Wilson J Michael Gaziano Howard S Sesso Amanda Black Neal D Freedman Wen-Yi Huang John G Anema Richard J Kahnoski Brian R Lane Sabrina L Noyes David Petillo Leandro M Colli Joshua N Sampson Celine Besse Helene Blanche Anne Boland Laurie Burdette Egor Prokhortchouk Konstantin G Skryabin Meredith Yeager Mirjana Mijuskovic Miodrag Ognjanovic Lenka Foretova Ivana Holcatova Vladimir Janout Dana Mates Anush Mukeriya Stefan Rascu David Zaridze Vladimir Bencko Cezary Cybulski Eleonora Fabianova Viorel Jinga Jolanta Lissowska Jan Lubinski Marie Navratilova Peter Rudnai Neonila Szeszenia-Dabrowska Simone Benhamou Geraldine Cancel-Tassin Olivier Cussenot H B As Bueno-de-Mesquita Federico Canzian Eric J Duell Börje Ljungberg Raviprakash T Sitaram Ulrike Peters Emily White Garnet L Anderson Lisa Johnson Juhua Luo Julie Buring I-Min Lee Wong-Ho Chow Lee E Moore Christopher Wood Timothy Eisen James Larkin Toni K Choueiri G Mark Lathrop Bin Tean Teh Jean-Francois Deleuze Xifeng Wu Richard S Houlston Paul Brennan Stephen J Chanock Ghislaine Scelo Mark P Purdue

Eur Urol 2018 09 28;74(3):e85-e86. Epub 2018 May 28.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, MS, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03022838183036
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http://dx.doi.org/10.1016/j.eururo.2018.05.017DOI Listing
September 2018

Genetics and genomics of breast fibroadenomas.

J Clin Pathol 2018 May 16;71(5):381-387. Epub 2017 Dec 16.

Department of Anatomical Pathology, Singapore General Hospital, Singapore.

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http://dx.doi.org/10.1136/jclinpath-2017-204838DOI Listing
May 2018

Functional genomics identifies specific vulnerabilities in PTEN-deficient breast cancer.

Breast Cancer Res 2018 03 22;20(1):22. Epub 2018 Mar 22.

Programme in Cancer and Stem Cell Biology, Duke-NUS Medical School, 8 College Road, Singapore, 169857, Singapore.

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http://dx.doi.org/10.1186/s13058-018-0949-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5863852PMC
March 2018

Genomic and Epigenomic Profiling of High-Risk Intestinal Metaplasia Reveals Molecular Determinants of Progression to Gastric Cancer.

Cancer Cell 2018 01 28;33(1):137-150.e5. Epub 2017 Dec 28.

Program in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore 169857, Singapore; Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599, Singapore; Cancer Therapeutics and Stratified Oncology, Genome Institute of Singapore, Singapore 138672, Singapore; SingHealth/Duke-NUS Institute of Precision Medicine, National Heart Centre Singapore, Singapore 169856, Singapore; Cellular and Molecular Research, National Cancer Centre, Singapore 169610, Singapore; Singapore Gastric Cancer Consortium, Singapore 119074, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2017.11.018DOI Listing
January 2018

A genetic mutation panel for differentiating malignant phyllodes tumour from metaplastic breast carcinoma.

Pathology 2017 Dec 21;49(7):786-789. Epub 2017 Oct 21.

Division of Pathology, Singapore General Hospital, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.pathol.2017.07.011DOI Listing
December 2017

Genetic Variants Related to Longer Telomere Length are Associated with Increased Risk of Renal Cell Carcinoma.

Authors:
Mitchell J Machiela Jonathan N Hofmann Robert Carreras-Torres Kevin M Brown Mattias Johansson Zhaoming Wang Matthieu Foll Peng Li Nathaniel Rothman Sharon A Savage Valerie Gaborieau James D McKay Yuanqing Ye Marc Henrion Fiona Bruinsma Susan Jordan Gianluca Severi Kristian Hveem Lars J Vatten Tony Fletcher Kvetoslava Koppova Susanna C Larsson Alicja Wolk Rosamonde E Banks Peter J Selby Douglas F Easton Paul Pharoah Gabriella Andreotti Laura E Beane Freeman Stella Koutros Demetrius Albanes Satu Mannisto Stephanie Weinstein Peter E Clark Todd E Edwards Loren Lipworth Susan M Gapstur Victoria L Stevens Hallie Carol Matthew L Freedman Mark M Pomerantz Eunyoung Cho Peter Kraft Mark A Preston Kathryn M Wilson J Michael Gaziano Howard S Sesso Amanda Black Neal D Freedman Wen-Yi Huang John G Anema Richard J Kahnoski Brian R Lane Sabrina L Noyes David Petillo Leandro M Colli Joshua N Sampson Celine Besse Helene Blanche Anne Boland Laurie Burdette Egor Prokhortchouk Konstantin G Skryabin Meredith Yeager Mirjana Mijuskovic Miodrag Ognjanovic Lenka Foretova Ivana Holcatova Vladimir Janout Dana Mates Anush Mukeriya Stefan Rascu David Zaridze Vladimir Bencko Cezary Cybulski Eleonora Fabianova Viorel Jinga Jolanta Lissowska Jan Lubinski Marie Navratilova Peter Rudnai Neonila Szeszenia-Dabrowska Simone Benhamou Geraldine Cancel-Tassin Olivier Cussenot H Bas Bueno-de-Mesquita Federico Canzian Eric J Duell Börje Ljungberg Raviprakash T Sitaram Ulrike Peters Emily White Garnet L Anderson Lisa Johnson Juhua Luo Julie Buring I-Min Lee Wong-Ho Chow Lee E Moore Christopher Wood Timothy Eisen James Larkin Toni K Choueiri G Mark Lathrop Bin Tean Teh Jean-Francois Deleuze Xifeng Wu Richard S Houlston Paul Brennan Stephen J Chanock Ghislaine Scelo Mark P Purdue

Eur Urol 2017 11 7;72(5):747-754. Epub 2017 Aug 7.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, MS, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03022838173063
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http://dx.doi.org/10.1016/j.eururo.2017.07.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5641242PMC
November 2017

Genomics of worms, with an emphasis on Opisthorchis viverrini - opportunities for fundamental discovery and biomedical outcomes.

Parasitol Int 2017 Aug 12;66(4):341-345. Epub 2016 Jan 12.

Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, Victoria 3010, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.parint.2016.01.005DOI Listing
August 2017

Genome-wide association study identifies multiple risk loci for renal cell carcinoma.

Authors:
Ghislaine Scelo Mark P Purdue Kevin M Brown Mattias Johansson Zhaoming Wang Jeanette E Eckel-Passow Yuanqing Ye Jonathan N Hofmann Jiyeon Choi Matthieu Foll Valerie Gaborieau Mitchell J Machiela Leandro M Colli Peng Li Joshua N Sampson Behnoush Abedi-Ardekani Celine Besse Helene Blanche Anne Boland Laurie Burdette Amelie Chabrier Geoffroy Durand Florence Le Calvez-Kelm Egor Prokhortchouk Nivonirina Robinot Konstantin G Skryabin Magdalena B Wozniak Meredith Yeager Gordana Basta-Jovanovic Zoran Dzamic Lenka Foretova Ivana Holcatova Vladimir Janout Dana Mates Anush Mukeriya Stefan Rascu David Zaridze Vladimir Bencko Cezary Cybulski Eleonora Fabianova Viorel Jinga Jolanta Lissowska Jan Lubinski Marie Navratilova Peter Rudnai Neonila Szeszenia-Dabrowska Simone Benhamou Geraldine Cancel-Tassin Olivier Cussenot Laura Baglietto Heiner Boeing Kay-Tee Khaw Elisabete Weiderpass Borje Ljungberg Raviprakash T Sitaram Fiona Bruinsma Susan J Jordan Gianluca Severi Ingrid Winship Kristian Hveem Lars J Vatten Tony Fletcher Kvetoslava Koppova Susanna C Larsson Alicja Wolk Rosamonde E Banks Peter J Selby Douglas F Easton Paul Pharoah Gabriella Andreotti Laura E Beane Freeman Stella Koutros Demetrius Albanes Satu Männistö Stephanie Weinstein Peter E Clark Todd L Edwards Loren Lipworth Susan M Gapstur Victoria L Stevens Hallie Carol Matthew L Freedman Mark M Pomerantz Eunyoung Cho Peter Kraft Mark A Preston Kathryn M Wilson J Michael Gaziano Howard D Sesso Amanda Black Neal D Freedman Wen-Yi Huang John G Anema Richard J Kahnoski Brian R Lane Sabrina L Noyes David Petillo Bin Tean Teh Ulrike Peters Emily White Garnet L Anderson Lisa Johnson Juhua Luo Julie Buring I-Min Lee Wong-Ho Chow Lee E Moore Christopher Wood Timothy Eisen Marc Henrion James Larkin Poulami Barman Bradley C Leibovich Toni K Choueiri G Mark Lathrop Nathaniel Rothman Jean-Francois Deleuze James D McKay Alexander S Parker Xifeng Wu Richard S Houlston Paul Brennan Stephen J Chanock

Nat Commun 2017 06 9;8:15724. Epub 2017 Jun 9.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1038/ncomms15724DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472706PMC
June 2017

Negative regulation of EGFR signalling by the human folliculin tumour suppressor protein.

Nat Commun 2017 06 28;8:15866. Epub 2017 Jun 28.

Center for Cancer Research, Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, Massachusetts 02139, USA.

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http://dx.doi.org/10.1038/ncomms15866DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5493755PMC
June 2017

MED12 protein expression in breast fibroepithelial lesions: correlation with mutation status and oestrogen receptor expression.

J Clin Pathol 2016 Oct 7;69(10):858-65. Epub 2016 Apr 7.

Department of Pathology, Singapore General Hospital, Singapore Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

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http://dx.doi.org/10.1136/jclinpath-2015-203590DOI Listing
October 2016

ADAR-Mediated RNA Editing Predicts Progression and Prognosis of Gastric Cancer.

Gastroenterology 2016 10 1;151(4):637-650.e10. Epub 2016 Jul 1.

Cancer Science Institute of Singapore, National University of Singapore, Singapore; Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2016.06.043DOI Listing
October 2016

Epigenomic Consequences of Coding and Noncoding Driver Mutations.

Trends Cancer 2016 10 30;2(10):585-605. Epub 2016 Sep 30.

Cancer and Stem Cell Biology Program, Duke-NUS Medical School, 8 College Road, Singapore 169857, Singapore; National Cancer Centre, 11 Hospital Drive, Singapore 169610, Singapore; Cancer Science Institute of Singapore, National University of Singapore, 14 Medical Drive, #12-01, Singapore 117599, Singapore; SingHealth/Duke-NUS Precision Medicine Institute, Singapore 168752, Singapore; Institute of Molecular and Cell Biology, 61 Biopolis Drive, Singapore 138673. Electronic address:

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http://dx.doi.org/10.1016/j.trecan.2016.09.002DOI Listing
October 2016

Effect of Ang-2-VEGF-A Bispecific Antibody in Renal Cell Carcinoma.

Cancer Invest 2015 26;33(8):378-86. Epub 2015 Jun 26.

a Laboratory of Cancer Epigenome , National Cancer Centre Singapore , Singapore.

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http://dx.doi.org/10.3109/07357907.2015.1047505DOI Listing
April 2016

Defining the Molecular Alterations of Ampullary Carcinoma.

Cancer Cell 2016 Feb;29(2):135-6

Laboratory of Cancer Epigenome, National Cancer Centre Singapore, 11 Hospital Drive, Singapore 169610, Singapore; Division of Cancer and Stem Cell Biology, Duke-NUS Graduate Medical School, 8 College Road, Singapore 169857, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2016.01.011DOI Listing
February 2016

NanoString expression profiling identifies candidate biomarkers of RAD001 response in metastatic gastric cancer.

ESMO Open 2016 17;1(1):e000009. Epub 2016 Feb 17.

Cancer and Stem Cell Biology Program, Duke-NUS Medical School; Genome Institute of Singapore, Biopolis, Singapore; Cancer Science Institute of Singapore, National University of Singapore, Singapore.

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http://dx.doi.org/10.1136/esmoopen-2015-000009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5070203PMC
February 2016

Serglycin expression: An independent marker of distant metastases in nasopharyngeal carcinoma.

Head Neck 2016 Jan 27;38(1):21-8. Epub 2015 Jan 27.

Department of Surgical Oncology, National Cancer Centre Singapore, Singapore.

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http://dx.doi.org/10.1002/hed.23841DOI Listing
January 2016

Fumarate Hydratase-deficient Cell Line NCCFH1 as a New In Vitro Model of Hereditary Papillary Renal Cell Carcinoma Type 2.

Anticancer Res 2015 Dec;35(12):6639-53

Division of Medical Sciences, National Cancer Centre Singapore, Singapore, Republic of Singapore Division of Cancer and Stem Cell Biology, Duke-NUS Graduate Medical School, Singapore, Republic of Singapore

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December 2015

Methylation profiles reveal distinct subgroup of hepatocellular carcinoma patients with poor prognosis.

PLoS One 2014 5;9(8):e104158. Epub 2014 Aug 5.

Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore; Division of Medical Sciences, Humphrey Oei Institute of Cancer Research, National Cancer Centre Singapore, Singapore, Singapore; NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore, Singapore; Duke-NUS Graduate Medical School, Singapore, Singapore.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0104158PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4122406PMC
November 2015

Flcn-deficient renal cells are tumorigenic and sensitive to mTOR suppression.

Oncotarget 2015 Oct;6(32):32761-73

Department of Cell Biology and Genetics, Zunyi Medical University, Zunyi 563099, China.

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http://dx.doi.org/10.18632/oncotarget.5018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741728PMC
October 2015

MSIseq: Software for Assessing Microsatellite Instability from Catalogs of Somatic Mutations.

Sci Rep 2015 Aug 26;5:13321. Epub 2015 Aug 26.

Centre for Computational Biology, Duke-NUS Graduate Medical School, Singapore, 169857, Singapore.

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http://dx.doi.org/10.1038/srep13321DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4549793PMC
August 2015

Exome-wide Sequencing Shows Low Mutation Rates and Identifies Novel Mutated Genes in Seminomas.

Eur Urol 2015 Jul 14;68(1):77-83. Epub 2015 Jan 14.

Centre for Computational Biology, Duke-NUS Graduate Medical School, Singapore; Program in Cancer and Stem Cell Biology, Duke-NUS Graduate Medical School, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.eururo.2014.12.040DOI Listing
July 2015

Chronic kidney disease and upper tract urothelial carcinomas.

Biomed Res Int 2014 11;2014:158918. Epub 2014 Sep 11.

Department of Medicine, College of Medicine, Chang Gung University, Taoyuan 33333, Taiwan ; Department of Nephrology, Linkou Chang Gung Memorial Hospital, Taoyuan 33333, Taiwan.

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http://dx.doi.org/10.1155/2014/158918DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4180636PMC
June 2015

Regulatory crosstalk between lineage-survival oncogenes KLF5, GATA4 and GATA6 cooperatively promotes gastric cancer development.

Gut 2015 May 22;64(5):707-19. Epub 2014 Jul 22.

Cancer and Stem Cell Biology program, Duke-NUS Graduate Medical School Singapore, Singapore, Singapore Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore Cellular and Molecular Research, National Cancer Centre, Singapore, Singapore Genome Institute of Singapore, Singapore, Singapore.

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http://dx.doi.org/10.1136/gutjnl-2013-306596DOI Listing
May 2015

Upper tract urothelial carcinomas in patients with chronic kidney disease: relationship with diagnostic challenge.

Biomed Res Int 2014 7;2014:989458. Epub 2014 Aug 7.

Department of Nephrology, Erasme Hospital, 1070 Brussels, Belgium.

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http://dx.doi.org/10.1155/2014/989458DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4142288PMC
May 2015

Genetics of Opisthorchis viverrini-related cholangiocarcinoma.

Curr Opin Gastroenterol 2015 May;31(3):258-63

aLaboratory of Cancer Epigenome, Division of Medical Sciences, National Cancer Centre Singapore bProgram in Cancer and Stem Cell Biology, Duke-NUS Graduate Medical School, Singapore cDepartment of Pharmacology, Faculty of Medicine dLiver Fluke and Cholangiocarcinoma Research Center, Khon Kaen University, Khon Kaen, Thailand eCancer Science Institute of Singapore, National University of Singapore, Singapore.

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http://dx.doi.org/10.1097/MOG.0000000000000162DOI Listing
May 2015

Mutation signatures implicate aristolochic acid in bladder cancer development.

Genome Med 2015 28;7(1):38. Epub 2015 Apr 28.

Program in Cancer and Stem Cell Biology, Duke-NUS Graduate Medical School, 8 College Road, Singapore, 169857 Singapore ; Centre for Computational Biology, Duke-NUS Graduate Medical School, 8 College Road, Singapore, 169857 Singapore.

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http://dx.doi.org/10.1186/s13073-015-0161-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4443665PMC
May 2015

An eleven gene molecular signature for extra-capsular spread in oral squamous cell carcinoma serves as a prognosticator of outcome in patients without nodal metastases.

Oral Oncol 2015 Apr 2;51(4):355-62. Epub 2015 Jan 2.

Department of Surgical Oncology, National Cancer Centre, 11 Hospital Drive, Singapore 169610, Singapore; Cancer and Stem Cell Biology, Duke-NUS Graduate Medical School, 8 College Road, Singapore 169857, Singapore; Cancer Therapeutics Research Laboratory, National Cancer Centre, 11 Hospital Drive, Singapore 169610, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.oraloncology.2014.12.012DOI Listing
April 2015

Pathogenesis of cholangiocarcinoma: From genetics to signalling pathways.

Best Pract Res Clin Gastroenterol 2015 Apr 17;29(2):233-44. Epub 2015 Feb 17.

Laboratory of Cancer Epigenome, Division of Medical Sciences, National Cancer Centre Singapore, Singapore; Division of Cancer and Stem Cell Biology, Duke-National University of Singapore (NUS) Graduate Medical School, Singapore; Cancer Science Institute of Singapore, National University of Singapore, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.bpg.2015.02.002DOI Listing
April 2015

Inhibition of placental growth factor in renal cell carcinoma.

Anticancer Res 2015 Jan;35(1):531-41

Laboratory of Cancer Epigenome, National Cancer Centre Singapore, Singapore, Singapore Program in Cancer and Stem Cell Biology, Duke-NUS Graduate Medical School, Singapore, Singapore Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.

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January 2015

Targeting cancer stem cell plasticity through modulation of epidermal growth factor and insulin-like growth factor receptor signaling in head and neck squamous cell cancer.

Stem Cells Transl Med 2014 Sep 14;3(9):1055-65. Epub 2014 Jul 14.

Cancer Therapeutics Research Laboratory, Laboratory of Cancer Epigenome, Department of Medical Oncology, and Department of Surgical Oncology, National Cancer Centre Singapore, Singapore

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http://doi.wiley.com/10.5966/sctm.2013-0214
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http://dx.doi.org/10.5966/sctm.2013-0214DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4149297PMC
September 2014

The NF1 gene revisited - from bench to bedside.

Oncotarget 2014 Aug;5(15):5873-92

Cancer Therapeutics Laboratory, Centre for Personalised Cancer Medicine, University of Adelaide, Australia.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4171599PMC
http://dx.doi.org/10.18632/oncotarget.2194DOI Listing
August 2014

Exome sequencing identifies highly recurrent MED12 somatic mutations in breast fibroadenoma.

Nat Genet 2014 Aug 20;46(8):877-80. Epub 2014 Jul 20.

1] Laboratory of Cancer Epigenome, Division of Medical Sciences, National Cancer Centre Singapore, Singapore. [2] Division of Cancer and Stem Cell Biology, Duke-National University of Singapore (NUS) Graduate Medical School, Singapore. [3] Cancer Science Institute of Singapore, National University of Singapore, Singapore.

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http://dx.doi.org/10.1038/ng.3037DOI Listing
August 2014

The Succinated Proteome of FH-Mutant Tumours.

Metabolites 2014 Aug 7;4(3):640-54. Epub 2014 Aug 7.

Cancer Biology and Metabolism Group, Institute of Genetics and Molecular Medicine, Edinburgh Cancer Research UK Centre, University of Edinburgh, Western General Hospital, Crewe Road South, Edinburgh EH4 2XR, UK.

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http://dx.doi.org/10.3390/metabo4030640DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4192685PMC
August 2014

Nanoscale chromatin profiling of gastric adenocarcinoma reveals cancer-associated cryptic promoters and somatically acquired regulatory elements.

Nat Commun 2014 Jul 10;5:4361. Epub 2014 Jul 10.

1] Cancer Therapeutics and Stratified Oncology, Genome Institute of Singapore, 60 Biopolis Street, Genome #02-01, Singapore 138672, Singapore [2] Cancer and Stem Cell Biology Program, Duke-NUS Graduate Medical School, 8 College Road, Singapore 169857, Singapore [3] Cancer Science Institute of Singapore, National University of Singapore, 14 Medical Drive, #12-01, Singapore 117599, Singapore [4] Cellular and Molecular Research, National Cancer Centre, 11 Hospital Drive, Singapore 169610, Singapore.

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http://dx.doi.org/10.1038/ncomms5361DOI Listing
July 2014

Mutation signatures of carcinogen exposure: genome-wide detection and new opportunities for cancer prevention.

Genome Med 2014 31;6(3):24. Epub 2014 Mar 31.

Program in Cancer and Stem Cell Biology, Duke-NUS Graduate Medical School, 8 College Road, Singapore 169857, Singapore ; Duke-NUS Centre for Computational Biology, Duke-NUS Graduate Medical School, 8 College Road, Singapore 169857, Singapore.

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http://dx.doi.org/10.1186/gm541DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4062065PMC
July 2014

Abscisic acid perception and signaling: structural mechanisms and applications.

Acta Pharmacol Sin 2014 May;35(5):567-84

1] Laboratory of Structural Sciences, Center for Structural Biology and Drug Discovery, Van Andel Research Institute, Grand Rapids, MI 49503, USA [2] VARI-SIMM Center, Center for Structure and Function of Drug Targets, Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.

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http://dx.doi.org/10.1038/aps.2014.5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4813750PMC
May 2014

Exome sequencing identifies distinct mutational patterns in liver fluke-related and non-infection-related bile duct cancers.

Nat Genet 2013 Dec 3;45(12):1474-8. Epub 2013 Nov 3.

1] Laboratory of Cancer Epigenome, Division of Medical Sciences, National Cancer Centre Singapore, Singapore. [2] Division of Cancer and Stem Cell Biology, Duke-National University of Singapore Graduate Medical School, Singapore. [3] Liver Fluke and Cholangiocarcinoma Research Center, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand. [4].

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http://www.nature.com/articles/ng.2806
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http://dx.doi.org/10.1038/ng.2806DOI Listing
December 2013

Overexpression of asparagine synthetase and matrix metalloproteinase 19 confers cisplatin sensitivity in nasopharyngeal carcinoma cells.

Mol Cancer Ther 2013 Oct 16;12(10):2157-66. Epub 2013 Aug 16.

Corresponding Authors: Jian-Ting Zhang, Indiana University School of Medicine, 980 W. Walnut St., Walther Hall-C510, Indianapolis, IN 46202-5424.

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http://dx.doi.org/10.1158/1535-7163.MCT-12-1190DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3795908PMC
October 2013

CUL3 and NRF2 mutations confer an NRF2 activation phenotype in a sporadic form of papillary renal cell carcinoma.

Cancer Res 2013 Apr 30;73(7):2044-51. Epub 2013 Jan 30.

Interdisciplinary Renal Oncology Laboratory, Van Andel Research Institute, Grand Rapids, MI 49503, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-12-3227DOI Listing
April 2013

The effect of Aurora kinases on cell proliferation, cell cycle regulation and metastasis in renal cell carcinoma.

Int J Oncol 2012 Dec 20;41(6):2139-49. Epub 2012 Sep 20.

State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Department of Pharmacology, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, PR China.

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https://www.spandidos-publications.com/10.3892/ijo.2012.1633
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http://dx.doi.org/10.3892/ijo.2012.1633DOI Listing
December 2012