Publications by authors named "Bin Guo"

484 Publications

Effects of dexmedetomidine on postoperative cognitive function of sleep deprivation rats based on changes in inflammatory response.

Bioengineered 2021 Dec;12(1):7920-7928

Department of Anesthesiology, the Second Xiangya Hospital, Central South University, Changsha, Hunan, China.

We aimed to assess the effects of dexmedetomidine (DEX) on postoperative cognitive function of sleep deprivation (SD) rats based on changes in inflammatory response. Male rats were randomly divided into blank control (C), SD, DEX, and SD+DEX groups. The SD model was established through intraperitoneal injection of DEX. The escape latency was detected through Morris water maze test daily, and the mechanical withdrawal threshold and thermal withdrawal latency were detected for 8 d. The content of malondialdehyde (MDA) and activity of superoxide dismutase (SOD) in hippocampus homogenate were determined, and the morphological changes in neurons were detected through Nissl staining. The concentration of interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), and IL-6 in the hippocampus was detected by enzyme-linked immunosorbent assay, and the Rac1/protein kinase B (AKT)/nuclear factor-κB (NF-κB) expressions were detected by Western blotting. The changes in immunofluorescence localization of NF-κB were observed by confocal microscopy. Compared with SD group, the escape latency was shortened, original platform-crossing times increased, MDA content declined, SOD activity rose, neurons were arranged orderly and number of Nissl bodies increased in the hippocampal CA1 region, levels of IL-1β, TNF-α, and IL-6 in the hippocampus decreased, Rac1/AKT/NF-κB expressions were down-regulated, and proportion of NF-κB entering the nucleus declined in SD+DEX group ( < 0.05). DEX can effectively alleviate postoperative hippocampal inflammation and improve cognitive function of SD rats. The ability of DEX to relieve oxidative stress of hippocampal neurons, restore damaged cells, and reduce hippocampal inflammation in SD rats may be related to the Rac1/AKT/NF-κB pathway.
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http://dx.doi.org/10.1080/21655979.2021.1981757DOI Listing
December 2021

Retrieving zinc concentrations in topsoil with reflectance spectroscopy at Opencast Coal Mine sites.

Sci Rep 2021 Oct 7;11(1):19909. Epub 2021 Oct 7.

College of Geomatics, Xi'an University of Science and Technology, Xi'an, China.

Heavy metals contaminations in mining areas aroused wide concerns globally. Efficient evaluation of its pollution status is a basis for further soil reclamation. Visible and near-infrared reflectance (Vis-NIR) spectroscopy has been diffusely used for retrieving heavy metals concentrations. However, the reliability and feasibility of calibrated models were still doubtful. The present study estimated zinc (Zn) concentrations via the random forest (RF) and partial least squares regression (PLSR) using ground in-situ Zn concentrations as well as soil spectral reflectance at an Opencast Coal Mine of Ordos, China in February 2020. The coefficient of determination (R), root mean square error (RMSE), mean absolute error (MAE), and the ratio of performance to deviation (RPD) were selected to assess the robustness of the methods in estimating Zn contents. Moreover, the characteristic bands were chosen by Pearson correlation analysis and Boruta Algorithm. Finally, the comparison between RF and PLSR combined with eight spectral reflectance transformation methods was conducted for four concentration groups to determine the optimal model. The results indicated that: (1) Zn contents represented a skewed distribution (coefficient of variation (CV) = 33%); (2) the spectral reflectance tended to decrease with the increase of Zn contents during 580-1850 nm based on Savitzky-Golay smoothing (SG); (3) the continuous wavelet transform (CWT) demonstrated higher effectiveness than other spectral reflectance transformation methods in enhancing spectral responses, the R between Zn contents and the soil spectral reflectance achieved the highest (R = 0.71) by using CWT; (4) the RF combined with CWT exhibited the best performance than other methods in the current study (R = 0.97, RPD = 3.39, RMSE = 1.05 mg kg, MAE = 0.79 mg kg). The current study supplied a scientific scheme and theoretical support for predicting heavy metals concentrations via the Vis-NIR spectral method in possible contaminated areas such as coal mines and metallic mineral deposit areas.
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http://dx.doi.org/10.1038/s41598-021-99106-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8497582PMC
October 2021

High quality haplotype-resolved genome assemblies of Populus tomentosa Carr., a stabilized interspecific hybrid species widespread in Asia.

Mol Ecol Resour 2021 Sep 22. Epub 2021 Sep 22.

Department of Forest Ecosystems and Society, Oregon State University, Corvallis, Oregon, USA.

Populus has a wide ecogeographical range spanning the Northern Hemisphere, and interspecific hybrids are common. Populus tomentosa Carr. is widely distributed and cultivated in the eastern region of Asia, where it plays multiple important roles in forestry, agriculture, conservation, and urban horticulture. Reference genomes are available for several Populus species, however, our goals were to produce a very high quality de novo chromosome-level genome assembly in P. tomentosa genome that could serve as a reference for evolutionary and ecological studies of hybrid speciation throughout the genus. Here, combining long-read sequencing and Hi-C scaffolding, we present a high-quality, haplotype-resolved genome assembly. The genome size was 740.2 Mb, with a contig N50 size of 5.47 Mb and a scaffold N50 size of 46.68 Mb, consisting of 38 chromosomes, as expected with the known diploid chromosome number (2n = 2x = 38). A total of 59,124 protein-coding genes were identified. Phylogenomic analyses revealed that P. tomentosa is comprised of two distinct subgenomes, which we deomonstrate is likely to have resulted from hybridization between Populus adenopoda as the female parent and Populus alba var. pyramidalis as the male parent, with an origin of approximately 3.93 Ma. Although highly colinear, significant structural variation was found between the two subgenomes. Our study provides a valuable resource for ecological genetics and forest biotechnology.
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http://dx.doi.org/10.1111/1755-0998.13507DOI Listing
September 2021

Genome-wide analysis of the MYB-related transcription factor family and associated responses to abiotic stressors in Populus.

Int J Biol Macromol 2021 Sep 14;191:359-376. Epub 2021 Sep 14.

Beijing Advanced Innovation Center for Tree Breeding by Molecular Design, Beijing Forestry University, Beijing 100083, China; National Engineering Laboratory for Tree Breeding, College of Biological Sciences and Technology, Beijing Forestry University, Beijing 100083, China. Electronic address:

MYB proteins are one of the most abundant transcription factor families in the plant kingdom. Evidence has increasingly revealed that MYB-related proteins function in diverse plant biological processes. However, little is known about the genome-wide characterization and functions of MYB-related proteins in Populus, an important model and commercial tree species. In this study, 152 PtrMYBRs were identified and unevenly located on 19 Populus chromosomes. A phylogenetic analysis divided them into six major subgroups, supported by conserved gene organization, consensus motifs, and protein domain architecture. Promoter assessment and gene ontology classification results indicated that the MYB-related family is likely involved in plant development and responses to various environmental stressors. The Populus MYB-related family members showed various expression patterns in different tissues and stress conditions, implying their crucial roles in the development and stress responses in Populus. Co-expression analyses revealed that Populus MYB-related genes might participate in the regulation of antioxidant defense system and various signaling pathways in response to stress. The three-dimensional structures of different subgroup of Populus MYB-related proteins further provided functional information at the proteomic level. These findings provide valuable information for a prospective functional dissection of MYB-related proteins and genetic improvement of Populus.
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http://dx.doi.org/10.1016/j.ijbiomac.2021.09.042DOI Listing
September 2021

A novel peptidomimetic therapeutic for selective suppression of lung cancer stem cells over non-stem cancer cells.

Bioorg Chem 2021 Nov 8;116:105340. Epub 2021 Sep 8.

Department of Pharmacological & Pharmaceutical Sciences, University of Houston, 4849 Calhoun Rd, Houston, TX 77204-5037, USA; Department of Cancer Systems Imaging, MD Anderson Cancer Center, 1881 East Road, Houston, TX 77030-4009, USA. Electronic address:

Cancers are highly heterogeneous and typically contain a small subset of drug-resisting cells called tumor initiating cells or cancer stem cells (CSCs). CSCs can self-renew, divide asymmetrically, and often cause tumor invasion and metastasis. Therefore, treatments specifically targeting CSCs are critical to improve patient survival. Recently, we identified a highly specific peptidomimetic (peptoid - PCS2) that selectively binds to the CSC subpopulation of lung cancer over the remaining cancer cells (non-CSCs). Subsequently, we identified plectin as the target of PCS2. Plectin is an intracellular structural protein, which is involved in tumor invasion and metastasis when it appears on cell surface. While PCS2 monomer did not display any anti-cancer activity, we designed a series of homo-dimeric versions of PCS2, and identified PCS2D1.2 optimized homo-dimer that displayed highly specific cytotoxicity towards CSCs over non-CSCs. PCS2D1.2 effectively blocked the in vitro colony formation and cell migration, hallmarks of CSCs. Furthermore, PCS2D1.2 reduced the in vivo tumor formation. In both in vitro and in vivo studies, PCS2D1.2 effectively reduced plectin expression and/or plectin-rich CSCs, but had no effect on non-CSCs. Therefore, PCS2D1.2 has the potential to be developed as a highly CSC specific drug candidate, which can be used in combination with current anti-cancer drugs.
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http://dx.doi.org/10.1016/j.bioorg.2021.105340DOI Listing
November 2021

Global quantum discord in the Lipkin-Meshkov-Glick model at zero and finite temperatures.

J Phys Condens Matter 2021 Sep 27;33(49). Epub 2021 Sep 27.

Department of Physics, Wuhan University of Technology, Wuhan 430070, People's Republic of China.

We study the global quantum discord (GQD) in the Lipkin-Meshkov-Glick (LMG) model at zero and finite temperatures, in which all spins are mutually interacted and introduced in an external magnetic field (denoted by). We confirm that the high coordinate number is one of the most distinguishing features of the LMG model, which directly results in the nontrivial behaviors of quantum correlations. We compare the GQD with other quantum correlations measures (such as concurrence, quantum discord, and global entanglement) and find the remarkable difference between them. For instance, we find that GQD spreads in the entire system and captures more information on quantum correlations when comparing with concurrence and quantum (pairwise) discord. We discover that GQD can characterize multipartite correlations in the both broken phase (< 1) and the symmetric phase (⩾ 1), while global entanglement and its generalized fail. Moreover, we show that the ground-state GQD can identify second-order quantum phase transitions of the LMG model in the thermodynamic limit. By making the scaling behavior of the GQD in the LMG model analysis, we show that GQD (denoted byG) scales asG∼k⋅N+cwith> 0 in the anisotropic cases for any fixed magnetic field. We further show that GQD behaves asG|sn∼k⋅1N+cwith< 0 in the isotropic cases for any Dicke state |⟩. Hereinandare the fitting parameters. We also find that the thermal stability of the GQD at low temperatures depends on the energy gap. We further reveal that the extraordinary behaviors of the thermal-state GQD in the isotropic LMG model are explained by the contribution theory of the energy levels.
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http://dx.doi.org/10.1088/1361-648X/ac2647DOI Listing
September 2021

Deformation Behavior and Microstructural Evolution of T-Shape Upsetting Test in Ultrafine-Grained Pure Copper.

Materials (Basel) 2021 Aug 27;14(17). Epub 2021 Aug 27.

State Key Laboratory of Advanced Welding and Joining, Harbin Institute of Technology, Harbin 150001, China.

Ultrafine-grained (UFG) materials can effectively solve the problem of size effects and improve the mechanical properties due to its ultra-high strength. This paper is dedicated to analyzing the deformation behavior and microstructural evolution of UFG pure copper based on T-shape upsetting test. Experimental results demonstrate that: the edge radius and V-groove angle have significant effects on the rib height and aspect ratio λ during T-shape upsetting; while the surface roughness has little effect on the forming load in the first stage, but in the second stage the influence becomes significant. The dynamic recrystallization temperature of UFG pure copper is between 200 °C and 250 °C.
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http://dx.doi.org/10.3390/ma14174869DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8432700PMC
August 2021

TAZ as a novel regulator of oxidative damage in decidualization via Nrf2/ARE/Foxo1 pathway.

Exp Mol Med 2021 Sep 8;53(9):1307-1318. Epub 2021 Sep 8.

College of Veterinary Medicine, Jilin University, Changchun, PR China.

TAZ, as a crucial effector of Hippo pathway, is required for spermatogenesis and fertilization, but little is known regarding its physiological function in uterine decidualization. In this study, we showed that TAZ was localized in the decidua, where it promoted stromal cell proliferation followed by accelerated G1/S phase transition via Ccnd3 and Cdk4 and induced the expression or activity of stromal differentiation markers Prl8a2, Prl3c1 and ALP, indicating the importance of TAZ in decidualization. Knockdown of TAZ impeded HB-EGF induction of stromal cell proliferation and differentiation. Under oxidative stress, TAZ protected stromal differentiation against oxidative damage by reducing intracellular ROS and enhancing cellular antioxidant capacity dependent on the Nrf2/ARE/Foxo1 pathway. TAZ strengthened the transcriptional activity of Nrf2 which directly bound to the antioxidant response element (ARE) of Foxo1 promoter region. Additionally, silencing TAZ caused accumulation of intracellular ROS through heightening NOX activity whose blockade by APO reversed the disruption in stromal differentiation. Further analysis revealed that TAZ might restore mitochondrial function, as indicated by the increase in ATP level, mtDNA copy number and mitochondrial membrane potential with the reduction in mitochondrial superoxide. Additionally, TAZ modulated the activities of mitochondrial respiratory chain complexes I and III whose suppression by ROT and AA resulted in the inability of TAZ to defend against oxidative damage to stromal differentiation. Moreover, TAZ prevented stromal cell apoptosis by upregulating Bcl2 expression and inhibiting Casp3 activity and Bax expression. In summary, TAZ might mediate HB-EGF function in uterine decidualization through Ccnd3 and ameliorate oxidative damage to stromal cell differentiation via Nrf2/ARE/Foxo1 pathway.
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http://dx.doi.org/10.1038/s12276-021-00655-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8492733PMC
September 2021

ADGRG1 enriches for functional human hematopoietic stem cells following ex vivo expansion-induced mitochondrial oxidative stress.

J Clin Invest 2021 Oct;131(20)

Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of the Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

The heterogeneity of human hematopoietic stem cells (HSCs) and hematopoietic progenitor cells (HPCs) under stress conditions such as ex vivo expansion is poorly understood. Here, we report that the frequencies of SCID-repopulating cells were greatly decreased in cord blood (CB) CD34+ HSCs and HPCs upon ex vivo culturing. Transcriptomic analysis and metabolic profiling demonstrated that mitochondrial oxidative stress of human CB HSCs and HPCs notably increased, along with loss of stemness. Limiting dilution analysis revealed that functional human HSCs were enriched in cell populations with low levels of mitochondrial ROS (mitoROS) during ex vivo culturing. Using single-cell RNA-Seq analysis of the mitoROS low cell population, we demonstrated that functional HSCs were substantially enriched in the adhesion GPCR G1-positive (ADGRG1+) population of CD34+CD133+ CB cells upon ex vivo expansion stress. Gene set enrichment analysis revealed that HSC signature genes including MSI2 and MLLT3 were enriched in CD34+CD133+ADGRG1+ CB HSCs. Our study reveals that ADGRG1 enriches for functional human HSCs under oxidative stress during ex vivo culturing, which can be a reliable target for drug screening of agonists of HSC expansion.
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http://dx.doi.org/10.1172/JCI148329DOI Listing
October 2021

Multiple parameters and target optimization of splitter blades for axial spiral blade blood pump using computational fluid mechanics, neural networks, and particle image velocimetry experiment.

Sci Prog 2021 Jul-Sep;104(3):368504211039363

College of Mechanical and Electrical Engineering, 12570Central South University, China.

The blood pump is an implantable device with strict performance requirements. Any effective structural improvement will help to improve the treatment of patients. However, the research of blood pump structure improvement is a complex optimization problem with multiple parameters and objectives. This study takes the splitter blade as the object of structural improvement. Computational fluid mechanics and neural networks are combined in research and optimization. And hydraulic experiments and micro particle image velocimetry technology were used. In the optimization study, the number of blades, axial length and circumferential offset are optimization parameters, and hydraulic performance and hemolytic prediction index are optimization targets. The study analyzes the influence of each parameter on performance and completes the optimization of the parameters. In the results, the optimal parameters of number of blades, axial length ratio, and circumferential offset are 2.6° and 0.41°, respectively. Under optimized parameters, hydraulic performance can be significantly improved. And the results of hemolysis prediction and micro particle image velocimetry experiments reflect that there is no increase in the risk of hemolytic damage. The results of this study provide a method and ideas for improving the structure of the axial spiral blade blood pump. The established optimization method can be effectively applied to the design and research of axial spiral blade blood pumps with complex, high precision, and multiple parameters and targets.
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http://dx.doi.org/10.1177/00368504211039363DOI Listing
August 2021

"Molecular Masks" for ACE2 to Effectively and Safely Block SARS-CoV-2 Virus Entry.

Int J Mol Sci 2021 Aug 20;22(16). Epub 2021 Aug 20.

Department of Pharmacological & Pharmaceutical Sciences, University of Houston, 4849 Calhoun Rd, Houston, TX 77204-5037, USA.

Coronavirus Disease 2019 (COVID-19) remains a global health crisis, despite the development and success of vaccines in certain countries. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes COVID-19, uses its spike protein to bind to the human cell surface receptor angiotensin-converting enzyme 2 (ACE2), which allows the virus to enter the human body. Using our unique cell screening technology, we identified two ACE2-binding peptoid compounds and developed dimeric derivatives (ACE2P1D1 and ACE2P2D1) that effectively blocked spike protein-ACE2 interaction, resulting in the inhibition of SARS-CoV-2 pseudovirus entry into human cells. ACE2P1D1 and ACE2P2D1 also blocked infection by a D614G mutant pseudovirus. More importantly, these compounds do not decrease ACE2 expression nor its enzyme activity (which is important in normal blood pressure regulation), suggesting safe applicability in humans.
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http://dx.doi.org/10.3390/ijms22168963DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8396575PMC
August 2021

Isotope-Coding Derivatization for Quantitative Profiling of Reactive α-Dicarbonyl Species in Processed Botanicals by Liquid Chromatography-Tandem Mass Spectrometry.

J Agric Food Chem 2021 Sep 26;69(35):10379-10393. Epub 2021 Aug 26.

College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China.

α-Dicarbonyls (α-DCs) are key reactive Maillard intermediates with structural diversity and are widely found in foods and in vivo, but little is known regarding the complete molecular profiles of these potentially harmful electrophiles. Herein, we reported a novel isotope-coding derivatization (ICD) strategy for the broad-spectrum, quantitative profiling of (non)target α-DC species in natural foodstuffs. It utilized differential isotope labeling (DIOL) with a reagent pair -phenylenediamine (OPD)/OPD- (deuterated) to form stable quinoxalines for class-specific fragmentation-dependent acquisition using liquid chromatography-hybrid quadrupole linear ion trap mass spectrometry (LC-QqLIT). A combination of facile one-pot quantitative labeling and convenient cleanup protocol afforded satisfactory sensitivity, linearity, accuracy (81-116%), and process recovery (86-109% with RSDs < 10%) by matrix-matched ICD-internal standard calibration, without significant matrix interference (-9 to 5%), isotopic effect (<0.5%), and cocktail effect. A more generic DIOL-based LC-QqLIT algorithm integrated double precursor ion and neutral loss scan to trigger enhanced product ions with the unique isobaric doublet tags (4 Da shift), enabling simultaneous screening and relative quantitation of nontarget α-DC analogues in a single analysis. This study has widened the vision on complex α-DC profiles in traditional botanicals, which revealed a wide occurrence of α-DCs in such processed sugar-rich products, yet their abundance varied greatly among different samples.
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http://dx.doi.org/10.1021/acs.jafc.1c04122DOI Listing
September 2021

Secondary metabolites of endophytic fungi isolated from Huperzia serrata.

Fitoterapia 2021 Aug 19:104970. Epub 2021 Aug 19.

Fengxian Hospital, Southern Medical University, Shanghai 201499, China. Electronic address:

The natural product Huperzine A isolated from Huperzia serrata is a targeted inhibitor of acetylcholinesterase that has been approved for clinical use in the treatment of Alzheimer's disease. Given the large demand for natural sources of Huperzine A, efforts have been made to explore whether Huperzine A (Hup. A) is also produced by endophytic fungi from H. serrata and, if so, identify its biosynthetic pathway. These studies have indicated that endophytic fungi from H. serrata represent a huge and largely untapped resource for natural products (including Hup. A) with chemical structures that have been optimized by evolution for biological and ecological relevance. To date, more than three hundred endophytic fungi have been isolated from H. serrata, of which 9 strains can produce Hup. A, whilst more than 20 strains produce other important metabolites, such as polyketones, xanthones, alkaloids, steroids, triterpenoids, furanone derivatives, tremulane sesquitepenes and diterpenoids. In total, 200 secondary metabolites have been characterized in endophytic fungi from H. serrata to date. Functionally, some have cholinesterase-inhibitory or antibacterial activity. This review also considers the different classes of secondary metabolites produced by endophytic fungi, along with their possible applications. We systematically describe the taxonomy, biology, and chemistry of these secondary metabolites. It also summarizes the biosynthetic synthesis of metabolites, including that of Hup. A. The review will aid researchers in obtaining a clearer understanding of this plant-endophyte relationship to better exploit the excellent resources it offers that may be utilized by pharmaceutical industries.
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http://dx.doi.org/10.1016/j.fitote.2021.104970DOI Listing
August 2021

Genistein exhibits therapeutic potential for PCOS mice the ER-Nrf2-Foxo1-ROS pathway.

Food Funct 2021 Sep 20;12(18):8800-8811. Epub 2021 Sep 20.

College of Veterinary Medicine, Jilin University, Changchun, P. R. China.

Polycystic ovarian syndrome (PCOS) is a complex endocrinopathy in women of reproductive age and the main cause of female infertility, but there is no universal drug for PCOS therapy. As a predominant dietary isoflavone present in soybeans, genistein (GEN) possesses estrogenic and antioxidative properties, but limited information is available regarding its therapeutic potential and underlying molecular mechanism in PCOS. In this study, we found that GEN might restore the estrous cycle of PCOS mice and ameliorate the elevation of circulating T, AMH and LH levels as well as LH/FSH ratios along with reduced cystic follicles, indicating the importance of GEN in PCOS therapy. Meanwhile, GEN improved the ovarian secretion function of PCOS mice and attenuated oxidative damage of the ovary through enhancing its antioxidant capability dependent on ER. Supplementation of GEN improved the defect of the ATP level and mitochondrial membrane potential, indicating the significance of GEN in preventing mitochondrial dysfunction. Further analysis demonstrated that GEN ER heightened the expression of Nrf2 and Foxo1 whose blockage antagonized the defence of GEN on the secretory and mitochondrial functions of ovarian granulosa cells followed by the limited antioxidant capability and increased intracellular ROS level. Moreover, nuclear translocation and transcriptional activity of Nrf2 presented a notable enhancement after exposure to GEN. Addition of the Nrf2 inhibitor ML385 hampered the GEN induction of Foxo1. Nrf2 might directly bind to the antioxidant response element of the Foxo1 promoter region. Collectively, GEN might exhibit therapeutic potential for PCOS mice the ER-Nrf2-Foxo1-ROS pathway.
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http://dx.doi.org/10.1039/d1fo00684cDOI Listing
September 2021

Antiplatelet Therapy with Integrated Traditional Chinese and Western Medicine for Use in Myocardial Ischemia-Reperfusion Injury: A Review of Clinical Applications and Mechanisms.

Evid Based Complement Alternat Med 2021 20;2021:7409094. Epub 2021 Jul 20.

Department of Cardiology, Dong Fang Hospital, Fengtai District, Beijing University of Chinese Medicine, Beijing 100078, China.

Myocardial ischemia-reperfusion injury (MIRI) is common in patients with acute coronary syndrome (ACS) after PCI treatment, which seriously affects the efficacy of revascularization and hinders the postoperative recovery of patients; therefore, the current study is focused on determining effective methods in the treatment of MIRI. Antiplatelet therapy is a routine treatment for ACS, and its benefits for treating MIRI have been previously verified. With the development of traditional Chinese medicine (TCM), many TCM preparations are widely used in the clinic. Many basic and clinical studies have shown that TCM can be used together with antiplatelet drugs, and the safety and efficacy when TCM is included in the treatment are better than when antiplatelet drugs are used alone. This paper summarizes the current research progress of traditional Chinese medicine and Western medicine in the treatment of MIRI to provide a theoretical basis for further research and clinical treatment.
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http://dx.doi.org/10.1155/2021/7409094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8318772PMC
July 2021

Climatic ecological suitability and potential distribution of in western Sichuan Plateau, China based on MaxEnt model.

Ying Yong Sheng Tai Xue Bao 2021 Jul;32(7):2525-2533

Meteorological Bureau of Aba, Maerkang 624000, Sichuan, China.

Based on the distribution data of obtained from field investigation and literature, the ecological-niche factor analysis (ENFA) and the maximum entropy model (MaxEnt) were used to simulate the distribution law and suitable area of in the western Sichuan Plateau. The prediction was made for the future changes in the suitable area of by analyzing the relationship between climate factors and dynamic distribution. The results showed that the area under curve (AUC) values of both the model training set and validation set were greater than 0.90, indicating that the model prediction results were extremely accurate. The environmental variables affecting the potential distribution of were mainly the lowest temperature in the coldest month, the coldest season precipitation, annual temperature difference and soil type, with accumulative contribution of 90.3%. The niche parameters of suitable distribution areas of were as follows: the lowest temperature in the coldest month was -18.5--5.4 ℃, the coldest season precipitation was less than 15.7 mm, the annual temperature difference was 39.5-45 ℃, and soil type was semi-leached soil, including dry red soil, cinnamon soil, gray cinnamon soil, black soil and grey forest soil. The suitable areas of were distributed in the southwest, south, central and east of the plateau at an altitude range of 1900-3600 m. The highly suita-ble areas were mainly distributed in some towns of Yajiang, Xiangcheng, Kangding, Jiulong, Daocheng, Litang, Batang, Danba, Maerkang, Xiaojin, Jinchuan, Lixian, Maoxian, . The moderately and lowly suitable areas were located in some towns of Derong, Daofu, Xinlong, Luhuo, Baiyu, Luding, Rangtang, Wenchuan, Heishui, Jiuzhaigou. The highly suitable areas were discontinuously distributed according to the direction of rivers and mountains. The moderately suitable areas were connected with the highly suitable areas, while the lowly suitable areas were the extension of the highly and moderately suitable areas. Future climate change would be beneficial to the growth of . on the western Sichuan Plateau, while the climate-suitable areas would show an overall increasing trend. Suitable areas in the low-altitude Minjiang River Basin would be more affected by climate change than those located in high-altitude areas.
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http://dx.doi.org/10.13287/j.1001-9332.202107.013DOI Listing
July 2021

Residual characteristics and potential integrated risk assessment of synthetic pyrethroids in leafy vegetables from Zhejiang in China - Based on a 3-year investigation.

Food Chem 2021 Dec 16;365:130389. Epub 2021 Jun 16.

Key Laboratory of Microbial Technology for Industrial Pollution Control of Zhejiang Province, College of Environment, Zhejiang University of Technology, Hangzhou, Zhejiang 310032, China.

Leafy vegetables have high nutritional value and are very popular in China. However, the long-term variation in residues and integrated risks of synthetic pyrethroids (SPs) in these vegetables have not been well examined. In this study, a total of 1005 samples were collected from 55 markets during 2017-2019. The cumulative exposure to nine kinds of SPs in Zhejiang, China, through the consumption of nine leafy vegetables was analyzed, and the potential integrated risk was assessed by the relative potency factor. A total of 191 samples were detected with SPs residues. The most frequently detected SPs were λ-cyhalothrin and cypermethrin. The integrated risk assessment results revealed that the dietary risk for these SPs via leafy vegetable exposure is acceptable for children, adults and elderly individuals. The data provided here will be helpful for the government to formulate food policies in China.
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http://dx.doi.org/10.1016/j.foodchem.2021.130389DOI Listing
December 2021

Consecutive soybean (Glycine max) planting and covering improve acidified tea garden soil.

PLoS One 2021 13;16(7):e0254502. Epub 2021 Jul 13.

Anxi College of Tea Science, Fujian Agriculture and Forestry University, Quanzhou, Fujian, China.

Planting soybeans (Glycine max (L.) Merr.) in tea gardens decreased soil pH in theory but increased it in practice. This controversy was addressed in this study by treating the tea garden soil consecutively with different parts of a soybean cover crop: aboveground soybean (ASB) parts, underground soybean (USB) root residues, and the whole soybean (WSB) plants. In comparison with the control, the soil pH increased significantly after the third ASB and WSB treatments, but there was no significant change in the soil pH in the USB treatment. Concordantly, the soil exchangeable acidity decreased significantly and the soil exchangeable bases increased significantly in the ASB and WSB treatments. The exchangeable acidity increased in the USB treatment, but the amount of the increased acidity was less than that of the increased bases in the ASB treatment, resulting in a net increase in the exchangeable bases in the WSB treatment. Soybean planting and covering also increased the microbial richness and abundance significantly, which led to significantly more soil organic matters. Exchangeable K+ and Mg2+, and soil organic matters played significantly positive roles and exchangeable Al3+ played negative roles in improving soil pH. Our data suggest that consecutive plantings of soybean cover crop increase the pH of the acidified tea garden soil.
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0254502PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8277052PMC
July 2021

Validation of the Chinese Version of the Gender Identity/Gender Dysphoria Questionnaire for Adolescents and Adults.

J Sex Med 2021 09 8;18(9):1632-1640. Epub 2021 Jul 8.

Vanke School of Public Health, Tsinghua University, Beijing, China. Electronic address:

Background: The number of individuals with potential gender dysphoria (GD) being referred to specialized gender identity clinics or programs is increasing internationally; these cases are initially screened using the Gender Identity/Gender Dysphoria Questionnaire for Adolescents and Adults (GIDYQ-AA).

Aim: The current study aimed to assess the psychometric properties of the GIDYQ-AA in a sample of adolescents and young adults from China.

Methods: A cross-sectional study was conducted in October 2020. Sociodemographic information of the participants was first collected. Participants then completed the GIDYQ-AA, the Generalized Anxiety Disorder-7 scale, the Patient Health Questionnaire-9, and a suicidal ideation assessment. A total of 2,533 participants with a mean age of 19.30 (SD = 1.19) years were recruited. Of the participants, 841 (33.2%) were cis men, 1,589 (62.7%) were cis women, 66 (2.6%) self-identified as transgender, 17 (0.7%) self-identified as non-binary, and 20 (0.8%) self-identified as gender queer.

Results: The GIDYQ-AA had high internal consistency with a Cronbach's alpha = 0.89. Exploratory factor analysis showed that the GIDYQ-AA had a four-factor structure in China. The GIDYQ-AA was significantly correlated with anxiety symptoms (r = -0.32, P < .01), depressive symptoms (r = -0.33, P < .01), and suicidal ideation (r = -0.20, P < .01).

Clinical Translation: The Chinese version of GIDYQ-AA is a useful measurement with high practical value, which could promote the assessment and research of GD across China or among Chinese migrants in other countries.

Strengths And Limitations: This is the first study assessing the psychometric properties of the GIDYQ-AA in Chinese adolescents and young adults. The convergent and divergent validity of the GIDYQ-AA were not examined due to the unavailability of data. Also, the sample did not have an equal distribution of male to males and female to females.

Conclusion: The Chinese version of GIDYQ-AA is a useful measure, which could promote both the assessment and research of GD in the Chinese population. Wang Y, Feng Y, Su D, et al. Validation of the Chinese Version of the Gender Identity/Gender Dysphoria Questionnaire for Adolescents and Adults. J Sex Med 2021;18:1632-1640.
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http://dx.doi.org/10.1016/j.jsxm.2021.05.007DOI Listing
September 2021

A ratiometric dual luciferase reporter for quantitative monitoring of pre-mRNA splicing efficiency in vivo.

J Biol Chem 2021 Aug 1;297(2):100933. Epub 2021 Jul 1.

Engineering Research Center of Molecular and Neuro Imaging, Ministry of Education, School of Life Science and Technology, Xidian University, Xi'an, China; Institute of Medical Engineering, School of Basic Medical Sciences, Xi'an Jiaotong University, Xi'an, China; School of Pharmacy, Shaanxi Institute of International Trade & Commerce, Xi'an, China. Electronic address:

Precursor messenger RNA (pre-mRNA) splicing is critical for cell growth and development, and errors in RNA splicing frequently cause cellular dysfunction, abnormal gene expression, and a variety of human diseases. However, there is currently a lack of reliable systems to noninvasively monitor the mRNA splicing efficiency in cells and animals. Here, we described the design of a genetically engineered ratiometric dual luciferase reporter to continuously quantify the changes in mRNA splice variants in vivo. This reporter system is encoded within a single polypeptide but on separate exons, thus generating two distinct luciferase signals derived from spliced and unspliced mRNAs. With this reporter, the two kinds of luciferase in the same individual can minimize the influence of indirect factors on splicing, and the ratio of these two luciferase intensities represents the dynamic splicing efficiency of pre-mRNA. Our study offers a convenient and robust tool for the screening and identification of small molecules or trans-acting factors that affect the efficiency of specific splicing reactions.
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http://dx.doi.org/10.1016/j.jbc.2021.100933DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8322121PMC
August 2021

Catalytic synthesis of nanodiamond based on CDC principle: influence of different catalysts on types and sizes.

Nanotechnology 2021 Jul 7;32(39). Epub 2021 Jul 7.

State Key Laboratory of Metastable Materials Science and Technology, Yanshan University, Qinhuangdao 066004, People's Republic of China.

Recently, we have successfully realized the catalytic synthesis of nanodiamond (ND) by embedding the Fe catalyst into carbide under high stress, followed by chlorine-etching at atmospheric pressure. In this work, we selected Fe, Co and Ni as the catalyst, and TiC as the precursor, aiming at investigating the influence of the catalyst type on the synthesis of NDs. The results have shown that all the three catalysts can catalyze the synthesis of ND structure, where various types of NDs have been observed. Furthermore, the crystal type and plasticity of the catalyst may have an important influence on the type and size of the resultant ND. In the case of Fe and Ni as the catalyst, both of which have a face centered cubic crystal structure, the types of NDs obtained are mainly C-type and R-type but only a few H-type. However, when the Co with a close-packed hexagonal crystal structure is used as the catalyst, more H-type NDs can be catalytically synthesized. Moreover, more small-sized NDs have been catalytically synthesized by Co, which may be ascribed to the worse plasticity of Co by comparison to Fe and Ni.
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http://dx.doi.org/10.1088/1361-6528/ac0d7fDOI Listing
July 2021

The potential of medicinal plant extracts in improving the phytoremediation capacity of Solanum nigrum L. for heavy metal contaminated soil.

Ecotoxicol Environ Saf 2021 Sep 8;220:112411. Epub 2021 Jun 8.

Key Lab of Pollution Ecology and Environmental Engineering, Institute of Applied Ecology, Chinese Academy of Sciences, Shenyang 110016, PR China. Electronic address:

This study focused on the effects of eight medicinal plant extracts on Solanum nigrum L. potential to accumulate Cd and Pb from soil. These medicinal plants were common and relatively cheap. The eight 10% water extracts were made from the peel of Citrus reticulata Blanco (PCR), fruit of Phyllanthus emblica L. (FPE), root of Pueraria Lobata (Willd.) Ohwi (RPL), rhizome of Polygonatum sibiricum Red (RPS), root of Astragalus propinquus Schischkin (RAP), bud of Hemerocallis citrina Baroni (BHC), seed of Nelumbo nucifera Gaertn (SNN) and fruit of Prunus mume (Sieb.) Sieb.etZuce (FPM). The results showed that among all exposures, the treatment with FPE resulted in the significant increase (p < 0.05) of Cd and Pb concentration in shoots and roots of S. nigrum by 32.5% and 65.2% for Cd, and 38.7% and 39.6% for Pb. The biomasses of S. nigrum in all plant extract treatments were not significantly changed (p < 0.05) compared to the control (CK). The Cd and Pb extraction rates of S. nigrum in FPE treatment were increased respectively by 60.5% and 40.5% compared to CK. Though the treatment with EDTA significantly improved (p < 0.05) the concentration of Cd and Pb of S. nigrum, the Cd and Pb masses (ug plant) of S. nigrum did not show any significant difference compared to the CK due to the significant decrease in the shoot (20.4%) and root (22.0%) biomasses. The chelative role of FPE might be relation with its higher polyphenolic compounds. However, not sure if the contents of polyphenolic compounds was the only differences between FPE and other additives. Thus, some unknown organic matters might also play active role. This study provided valuable information on improving the phytoremediation potential of hyperaccumulator.
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http://dx.doi.org/10.1016/j.ecoenv.2021.112411DOI Listing
September 2021

[Bioinformatics Analysis of the Influence of Coronavirus Infection on Hematopoietic System and Potential Intervention Drugs and Their Significance for COVID-19].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2021 Jun;29(3):975-982

Medical School of Chinese PLA, Beijing 100853,China,Department of Hematology, The Second Medical Center, Chinese PLA General Hospital, Beijing 100853, China,E-mail:

Objective: To analyze and predict the effect of coronavirus infection on hematopoietic system and potential intervention drugs, and explore their significance for coronavirus disease 2019 (COVID-19).

Methods: The gene expression omnibus (GEO) database was used to screen the whole genome expression data related with coronavirus infection. The R language package was used for differential expression analysis and KEGG/GO enrichment analysis. The core genes were screened by PPI network analysis using STRING online analysis website. Then the self-developed apparent precision therapy prediction platform (EpiMed) was used to analyze diseases, drugs and related target genes.

Results: A database in accordance with the criteria was found, which was derived from SARS coronavirus. A total of 3606 differential genes were screened, including 2148 expression up-regulated genes and 1458 expression down-regulated genes. GO enrichment mainly related with viral infection, hematopoietic regulation, cell chemotaxis, platelet granule content secretion, immune activation, acute inflammation, etc. KEGG enrichment mainly related with hematopoietic function, coagulation cascade reaction, acute inflammation, immune reaction, etc. Ten core genes such as PTPRC, ICAM1, TIMP1, CXCR5, IL-1B, MYC, CR2, FSTL1, SOX1 and COL3A1 were screened by protein interaction network analysis. Ten drugs with potential intervention effects, including glucocorticoid, TNF-α inhibitor, salvia miltiorrhiza, sirolimus, licorice, red peony, famciclovir, cyclosporine A, houttuynia cordata, fluvastatin, etc. were screened by EpiMed plotform.

Conclusion: SARS coronavirus infection can affect the hematopoietic system by changing the expression of a series of genes. The potential intervention drugs screened on these grounds are of useful reference significance for the basic and clinical research of COVID-19.
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http://dx.doi.org/10.19746/j.cnki.issn.1009-2137.2021.03.051DOI Listing
June 2021

Design, Synthesis, and Biological Evaluation of Novel Pyrimido[4,5-]indole Derivatives Against Gram-Negative Multidrug-Resistant Pathogens.

J Med Chem 2021 06 3;64(12):8644-8665. Epub 2021 Jun 3.

State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.

Due to the poor permeability across Gram-negative bacterial membranes and the troublesome bacterial efflux mechanism, only a few GyrB/ParE inhibitors with potent activity against Gram-negative pathogens have been reported. Among them, pyrimido[4,5-]indole derivatives represented by GP-1 demonstrated excellent broad-spectrum antibacterial activity against both Gram-positive and Gram-negative bacteria but were limited by hERG inhibition and poor pharmacokinetics profile. To improve their drug-like properties, we designed a series of novel pyrimido[4,5-]indole derivatives based on the tricyclic scaffold of GP-1 and the C-7 moiety of acorafloxacin. These efforts have culminated in the discovery of a promising compound with reduced hERG liability and an improved PK profile. Compound exhibited superior broad-spectrum antibacterial activity compared to GP-1, including a variety of clinical multidrug G pathogens, especially , and the efficacy was also demonstrated in a neutropenic mouse thigh model of infection with multidrug-resistant .
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http://dx.doi.org/10.1021/acs.jmedchem.1c00621DOI Listing
June 2021

Interference Cancellation Based Spectrum Sharing for Massive MIMO Communication Systems.

Sensors (Basel) 2021 May 21;21(11). Epub 2021 May 21.

School of Electronics and Information Engineering, Changchun University of Science and Technology, Changchun 130022, China.

Cellular network operators are predicting an increase in space of more than 200 percent to carry the move and tremendous increase of total users in data traffic. The growing of investments in infrastructure such as a large number of small cells, particularly the technologies such as LTE-Advanced and 6G Technology, can assist in mitigating this challenge moderately. In this paper, we suggest a projection study in spectrum sharing of radar multi-input and multi-output, and mobile LTE multi-input multi-output communication systems near base stations (BS). The radar multi-input multi-output and mobile LTE communication systems split different interference channels. The new approach based on radar projection signal detection has been proposed for free interference disturbance channel with radar multi-input multi-output and mobile LTE multi-input multi-output by using a new proposed interference cancellation algorithm. We chose the channel of interference with the best free channel, and the detected signal of radar was projected to null space. The goal is to remove all interferences from the radar multi-input multi-output and to cancel any disturbance sources from a chosen mobile Communication Base Station. The experimental results showed that the new approach performs very well and can optimize Spectrum Access.
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http://dx.doi.org/10.3390/s21113584DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8196734PMC
May 2021

Unraveling the genetic diversity and structure of population through analysis of microsatellite markers.

PeerJ 2021 14;9:e10922. Epub 2021 Apr 14.

Beijing Forestry University, Beijing, China.

Background: Koidz. is an ecologically and economically important tree species widely distributed in Northern China. However, the effective assessment, utilization, and protection of resources remain unexplored.

Methods: In total, 120 samples obtained from 12 populations of Northern China were investigated for genetic diversity and structure using 19 simple sequence repeat (SSR) primer pairs.

Results: The total number of alleles detected was 293, the average number of effective allele (e) was 6.084, the genetic differentiation coefficient (st) was 0.033, and the mean observed heterozygosity (o) and expected heterozygosity (e) were 0.690 and 0.801, respectively. Moreover, analysis of molecular variance (AMOVA) showed a 5.5% genetic variation among 12 populations, indicating that a high level of genetic diversity and a low degree of genetic differentiation among populations. STRUCTURE and cluster analysis divided the 12 populations into the following three subpopulations: Bashang Plateau subpopulation (SH), Liaodong Peninsula subpopulation (NC), and Loess Plateau subpopulation (other 10 populations). The cluster analysis based on 19 climatic factors was consistent with the genetic structure. A positive correlation was found between genetic distance and geographical distance ( = 0.638,  = 0.028) by the Mantel test, and two boundaries were found among the 12 populations by the Barrier analysis, indicating that populations existed isolated by geographical distance and physical barrier.

Conclusion: This study suggests that geographical isolation, physical barrier, climatic types, and natural hybridization promote the formation of genetic structures, which can contribute to future protection and genetic improvement of
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http://dx.doi.org/10.7717/peerj.10922DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8052960PMC
April 2021

Stem-loop-primer assisted isothermal amplification enabling high-specific and ultrasensitive nucleic acid detection.

Biosens Bioelectron 2021 Jul 12;184:113239. Epub 2021 Apr 12.

Department of Clinical Laboratory, Affiliated Hospital of North Sichuan Medical College, Nanchong, 637000, PR China; Department of Laboratory Medicine, North Sichuan Medical College, Nanchong, 637000, PR China; Translational Medicine Research Center, North Sichuan Medical College, Nanchong, 637000, PR China. Electronic address:

It is highly desired to perform accurate and rapid nucleic acid detections for disease diagnosis at resource-limited setting, such as small clinics, remote areas and home. However, the challenges in sample handling, expensive equipment and complicated operation make canonical polymerase chain reaction (PCR) impossible to run the point-of-care testing (POCT). Herein we report a novel nucleic acid detection method, named stem-loop-primer assisted isothermal amplification (SPA), which specifically and sensitively amplifies target nucleic acid by using Bst DNA polymerase, a pair of canonical PCR primers and their stem-loop derivatives. The stem-loop-primers are easily designed by adding a stem-loop sequence to the canonical PCR primers at 5'-ends. In contrast to loop-mediated isothermal amplification (LAMP), which is a widespread isothermal amplification technology, our SPA is more specific and convenient to design and run. Further, we have demonstrated that SPA can specifically detect type 16, 18, 52 and 58 Human Papilloma viruses (HPV) in cervical samples, suggesting its specificity and robustness for nucleic acid detection. Moreover, pH indicator based colorimetric SPA was developed, which offered 100% accuracy for HPV16 detection in cervical samples, thereby demonstrating its great potential for POCT nucleic acid testing.
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http://dx.doi.org/10.1016/j.bios.2021.113239DOI Listing
July 2021

SET Domain-Containing Protein 5 Enhances the Cell Stemness of Non-Small Cell Lung Cancer via the PI3K/Akt/mTOR Pathway.

J Environ Pathol Toxicol Oncol 2021 ;40(2):55-63

Respiratory Department, Chengwu Hospital, Affiliated to Shandong First Medical University, Shandong Province, 251400, China.

Background: SET domain-containing protein 5 (SETD5) could promote non-small cell lung cancer (NS-CLC) cell invasion, but the effect of SETD5 on NSCLC cell stemness characteristics is unknown. Thus we attempted to evaluate the effect of SETD5 on NSCLC stemness and its mechanism.

Methods: The expressions of SETD5 and stemness-related genes (SOX2, OCT4, ABCG2) were detected in NSCLC tissues by immunohistochemistry assay, qRT-PCR, and western blot. A SETD5 knockdown cell model was constructed by siRNA transfection in A549 and H1299 cells. A CCK8 assay was used to examine cell viability. A sphere-forming assay and side population cell assay were conducted to measure the cancer cell stem properties. The cells with SETD5 deletion were treated with an activator of AKT, SC79, and the protein expressions of Akt, p-Akt, mTOR, and p-mTOR were assessed.

Results: SETD5 and cancer stem-related genes SOX2, OCT4, and ABCG2 were co-expressed and co-localized in tumor tissues and cell lines of NSCLC. The deletion of SETD5 significantly reduced the cell viability, cancer stem properties, and activity of the PI3K/Akt/mTOR pathway, while the decreased SETD5-induced effects were partially restored with SC79 treatment.

Conclusion: In this study, SETD5 promoted the cancer stem cell property of NSCLC through mitigating the activation of the PI3K/Akt/mTOR pathway, suggesting a candidate target role for SETD5 in NSCLC treatment.
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http://dx.doi.org/10.1615/JEnvironPatholToxicolOncol.2021036991DOI Listing
April 2021

Effects of corona virus disease-19 control measures on air quality in North China.

Environmetrics 2021 Mar 20;32(2):e2673. Epub 2021 Feb 20.

Guanghua School of Management Peking University Beijing P.R. China.

Corona virus disease-19 (COVID-19) has substantially reduced human activities and the associated anthropogenic emissions. This study quantifies the effects of COVID-19 control measures on six major air pollutants over 68 cities in North China by a Difference in Relative-Difference method that allows estimation of the COVID-19 effects while taking account of the general annual air quality trends, temporal and meteorological variations, and the spring festival effects. Significant COVID-19 effects on all six major air pollutants are found, with NO having the largest decline (-39.6%), followed by PM (-30.9%), O (-16.3%), PM (-14.3%), CO (-13.9%), and the least in SO (-10.0%), which shows the achievability of air quality improvement by a large reduction in anthropogenic emissions. The heterogeneity of effects among the six pollutants and different regions can be partly explained by coal consumption and industrial output data.
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http://dx.doi.org/10.1002/env.2673DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7995075PMC
March 2021

Fruit extracts from Phyllanthus emblica accentuate cadmium tolerance and accumulation in Platycladus orientalis: A new natural chelate for phytoextraction.

Environ Pollut 2021 Jul 22;280:116996. Epub 2021 Mar 22.

Shangyu District Agricultural Technology Extension Center, Shaoxing, 312000, China.

A key challenge for phytoextraction is the identification of high efficiency, growth-supporting, and low cost chelating agents. To date, no substance has satisfied all above criteria. This study investigated nine traditional Chinese herbs and found that Phyllanthus emblica fruit (FPE) extract could be utilised as an optimal chelate for the phytoextraction of cadmium (Cd)-contaminated soils. FPE application into soil at a ratio of 0.1% (w/w) significantly increased extractable Cd (by 43%) compared to the control. The success of FPE as a chelating agent was attributed to high quantities of polyphenol compounds (0.76%) and organic acids (9.6%), in particular, gallic acid (7.6%). Furthermore, antioxidative properties (1.4%) and free amino acids in FPE alleviated Cd-induced oxidant toxicity and enhanced plant biomass. FPE promoted 78% higher phytoextraction efficiency in Platycladus orientalis compared to traditional chelating agents (EDTA). Furthermore, 76% of FPE was degraded 90 days after the initial application, and there was no difference in extractable Cd between the treatment and control. FPE has been commercially produced at a lower market price than other biodegradable chelates. As a commercially available and cost-effective chelator, FPE could be utilised to treat Cd-contaminated soils without adverse environmental impacts.
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http://dx.doi.org/10.1016/j.envpol.2021.116996DOI Listing
July 2021
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