Publications by authors named "Bin Du"

689 Publications

Enhancing 2,6-dichlorophenol degradation and nitrate removal in the nano-zero-valent iron (nZVI) solid-phase denitrification system.

Chemosphere 2021 Sep 13;287(Pt 3):132249. Epub 2021 Sep 13.

Key Laboratory of Water Science and Water Environment Recovery Engineering, Beijing University of Technology, Beijing, 100123, China; State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, Harbin, 150090, PR China.

Nano-zero-valent iron (nZVI), as a typical nano-material, has been recently used in wastewater treatment and combination with bioreactors. Using nZVI coupled denitrification system research the effect and influence of nZVI enhanced denitrification sludge on the degradation of toxic compounds and system performance. The nZVI coupled denitrification system showed better resistance to 2,6-DCP impact, and the concentrations of effluent NO and NO were below 2.0 mg/L. At the same time, the addition of nZVI enabled the denitrification system to quickly adapt to the toxic environment of 2,6-DCP within 15 days, and the degradation efficiency of 2,6-DCP reached 99.9%. The released SMP reduced after nZVI coupled with denitrification sludge in 2,6-DCP environment, which could improve the effluent water quality. Nuclear magnetic resonance spectroscopy showed that the addition of nZVI would change the structure of EPS in denitrification sludge. After 90 days of operation, the dominant bacteria in the denitrifying sludge have undergone great changes. Moreover, Thauera was responsible as the dominant bacteria for degrading 2,6-DCP in the denitrification system. The increased in the proportion of functional bacteria with nitrate_reduction, nitrogen_respiration, nitrate_respiration and nitrite_respiration in the presence of NZVI further reveals the mechanism of enhanced denitrification.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.chemosphere.2021.132249DOI Listing
September 2021

Association between the modified Nutrition Risk in Critically Ill (mNUTRIC) score and clinical outcomes in the intensive care unit: a secondary analysis of a large prospective observational study.

BMC Anesthesiol 2021 09 8;21(1):220. Epub 2021 Sep 8.

Department of Critical Care Medicine, Fu Xing Hospital, Capital Medical University, no. 20 Fuxingmenwai Street, Xicheng District, Beijing, 100038, China.

Background: Malnutrition in intensive care unit (ICU) patients is associated with adverse clinical outcomes. The modified nutrition risk in the critically ill score (mNUTRIC) was proposed as an appropriate nutritional assessment tool in critically ill patients, but it has not been fully demonstrated and widely used. Our study was conducted to identify the nutritional risk in ICU patients using the mNUTRIC score and explore the relationship between 28-day mortality and high mNUTRIC scores.

Methods: This study is a secondary analysis, the data were extracted from The Beijing Acute Kidney Injury Trial (BAKIT). In total, 9049 patients were admitted consecutively, and 3107 patients with complete clinical data were included in this study. We divided the study population into high nutritional risk (mNUTRIC score ≥ 5 points) and low nutritional risk (mNUTRIC score < 5 points) groups. The predictive capacity of the mNUTRIC score was studied by receiver operating characteristic (ROC) curve analysis, appropriate cut-off was identified by highest combined sensitivity and specificity using Youden's index. The significance level was set at 5%.

Results: Among the 3107 patients, the 28-day mortality rate was 17.4% (540 patients died). Nearly 28.2% of patients admitted to the ICU were at risk of malnutrition, high nutritional risk patients were older (P < 0.001), with higher illness severity scores than low nutritional risk patients. Multivariate analysis revealed that the mNUTRIC score was an independent risk factor for 28-day mortality and mortality increased with increasing scores (p = 0.000). The calculated area under curve (AUC) for the mNUTRIC score was 0.763 (CI 0.740-0.786). According to Youden's index, we found a suitable cut-off > 4 for the mNUTRIC score to predict the 28-day mortality.

Conclusions: Patients admitted to the ICU were at high risk of malnutrition, and a high mNUTRIC score was associated with increased ICU length of stay and higher mortality. More large prospective studies are needed to demonstrate the validity of this score.

Trial Registration: This study was registered at www.chictr.org.cn (registration number Chi CTR-ONC-11001875 ). Registered on 14 December 2011.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12871-021-01439-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8424878PMC
September 2021

Ionic liquid-assisted fabrication of metal-organic framework-derived indium oxide/bismuth oxyiodide p-n junction photocatalysts for robust photocatalysis against phenolic pollutants.

J Colloid Interface Sci 2021 Aug 25;606(Pt 2):1261-1273. Epub 2021 Aug 25.

State Key Laboratory of Photocatalysis on Energy and Environment, Research Institute of Photocatalysis, Fuzhou University, Fuzhou 350116, PR China.

Constructing a p-n heterojunction is a feasible strategy to manipulate the dynamic behaviors of photogenerated carriers through an internal electric field. Herein, a novel highly efficient indium oxide/bismuth oxyiodide (InO/BiOI) p-n junction photocatalyst was fabricated using a facile ionic liquid-assisted precipitation method for the first time. The morphologies were modified by adding different amounts of acetic acid solution. Their hierarchical architecture was beneficial for adsorbing contaminants in wastewater, while the in-situ formed p-n heterojunction between BiOI and InO facilitated interfacial charge transfer and improved the quantum efficiency. Their visible light-responsive photocatalytic activities were systematically investigated by photocatalytic o-phenylphenol (OPP) and 4-tert-butylphenol (PTBP) oxidation. The degradation rate of OPP over InO/BiOI-2 was up to 5.67 times higher than that for BiOI. The excellent activity of InO/BiOI should be attributed to the rapid interfacial charge transfer, depressed carrier recombination, and proper band potentials. Trapping experiments and electron paramagnetic resonance characterizations confirmed the generation of hydroxyl radicals (•OH) and superoxide radicals (•O), which have played a key role in decomposing pollutants. The intermediate products generated during the photocatalytic degradation of OPP were detected and identified by liquid chromatography-mass spectrometry. Meanwhile, their possible molecular structures and degradation pathways have also been inferred.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jcis.2021.08.132DOI Listing
August 2021

A Method for Preparing Superhydrophobic Paper with High Stability and Ionic Liquid-Induced Wettability Transition.

Materials (Basel) 2021 Aug 18;14(16). Epub 2021 Aug 18.

Faculty of Printing, Packaging Engineering and Digital Media Technology, Xi'an University of Technology, Xi'an 710048, China.

In this study, the polymer PTSPM-PMETAC with anion adsorption properties was prepared by a one-step method, then the amino-modified nano-SiO was grafted onto the polymer to improve the roughness of the surface and enhance the stability of superhydrophobic properties, and a high-stability superhydrophobic paper with ion-induced wettability transition properties was successfully prepared. The study found that the paper can realize the reversible control of surface wettability through the exchange between the anions PF and Cl adsorbed on the surface of PMETAC, and further investigation of the effect of different solvents on the ion exchange properties found that water was the poor solvent for ion exchange, while the mixtures of methanol, acetone, and methanol & water were the good solvent. On the whole, the preparation of superhydrophobic paper by this method not only simple in preparation process, low in cost and strong in universality, but also the prepared superhydrophobic paper has high transparency and good stability, which has great application potential in industrial production.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3390/ma14164638DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8399005PMC
August 2021

Cellulosic films reinforced by chitosan-citric complex for meat preservation: Influence of nonenzymatic browning.

Carbohydr Polym 2021 Nov 22;272:118476. Epub 2021 Jul 22.

Beijing Laboratory of Food Quality and Safety, Beijing Key Laboratory of Agricultural Product Detection and Control of Spoilage Organisms and Pesticide Residue, Faculty of Food Science and Engineering, Beijing University of Agriculture, Beijing 102206, China. Electronic address:

The methods to obtain cellulose-chitosan composite films exhibiting excellent water-resisting and antibacterial abilities have been widely explored. Cellulose-chitosan-citric films (C-Ch-F) were successfully obtained by a facile coating of chitosan-citric complex on the surface of cellulose. The occurrence of nonenzymatic browning at 80 °C improved the thermal stability, water-resistance, mechanical property and oxygen-barrier ability of C-Ch-F membranes. C-Ch-F hydrogel showed excellent breaking stress of 6.03 ± 0.25 MPa, and elastic module of 27.09 ± 1.21 MPa, probably assigned to nonenzymatic browning. Under different test temperatures, the nonenzymatic browning and the content of chitosan-citric complex will significantly improve the oxygen barrier property of membranes (P < 0.05), and C-Ch-F membrane represented the value of oxygen permeation below the detection level. Excellent antibacterial capability of C-Ch-F hydrogels demonstrated that polycationic chitosan-citric complex immobilized in films still retained excellent antibacterial ability. The excellent decontamination in meat preservation endowed C-Ch-F films with potential application in food packaging.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.carbpol.2021.118476DOI Listing
November 2021

[A multicenter prospective cohort study of Xuebijing injection in the treatment of severe coronavirus disease 2019].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2021 Jul;33(7):774-778

State Key Laboratory of Respiratory Diseases, Department of Pulmonary and Critical Care Medicine, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, Guangdong, China.

Objective: To evaluate the effect of Xuebijing injection on the improvement of pneumonia severity index (PSI) and prognosis in patients with severe coronavirus disease 2019 (COVID-19).

Methods: A multicenter prospective cohort study was designed. Adult patients with COVID-19 admitted to the intensive care unit (ICU) of 28 designated COVID-19 hospitals in 15 provinces and cities of China from January to March 2020 were enrolled. All patients were treated according to the standard treatment plan of COVID-19 issued by the National Health Commission of the People's Republic of China. They were divided into Xuebijing group and standard treatment group according to whether they received Xuebijing injection or not. In the standard treatment group, routine medical care measures such as antiviral, respiratory support, circulatory support and symptomatic treatment were taken. In the Xuebijing group, on the basis of standard treatment, Xuebijing was used within 12 hours of admission to the ICU, 100 mL each time, twice daily. The minimum duration of Xuebijing administration was 1 day. The improvement rate of PSI risk rating on the 8th day and clinical outcome on the 28th day were recorded.

Results: A total of 276 COVID-19 patients were screened continuously, and the data of 144 severe patients who met PSI risk rating III-V were analyzed. Seventy-two cases were involved each in standard treatment group and Xuebijing group. The average age of the standard treatment group and Xuebijing group were (65.7±7.9) years old and (63.5±10.9) years old, and male accounted for 75.0% (54/72) and 70.8% (51/72), respectively. There were no significant differences in general conditions, comorbidities, PSI risk rating and score, sequential organ failure assessment (SOFA) score, oxygenation index (PaO/FiO), respiratory support mode and other baseline indicators between the two groups. Compared with the standard treatment group, the improvement rate of PSI risk rating in Xuebijing group on the 8th day after admission was significantly improved [56.9% (41/72) vs. 20.8% (15/72), between-group difference and 95% confidence interval (95%CI) was 36.1% (21.3% to 50.9%), P < 0.01], PSI score, SOFA score and PaO/FiO were significantly improved [PSI score: 83.7±34.8 vs. 108.2±25.6, between-group difference (95%CI) was -24.5 (-34.9 to -14.1); SOFA score: 2.0 (1.0, 4.0) vs. 7.0 (4.0, 10.0), between-group difference (95%CI) was -3.5 (-5.0 to -2.0); PaO/FiO (mmHg, 1 mmHg = 0.133 kPa): 289.4±111.6 vs. 188.5±98.1, between-group difference (95%CI) was 100.9 (65.3 to 136.5); all P < 0.01]. The 28-day discharge rate of Xuebijing group was 44.5% higher than that of standard treatment group [66.7% (48/72) vs. 22.2% (16/72), P < 0.01], and the 28-day survival rate was 9.8% [91.7% (66/72) vs. 81.9% (59/72), P < 0.01]. There was no significant difference in the combination of antiviral drugs, antibiotics, anticoagulants and vasopressor drugs between the two groups. There was no significant difference in the incidence of adverse events between the Xuebijing group and standard treatment group [41.7% (30/72) vs. 43.1% (31/72), P > 0.05], and no serious adverse events and adverse reactions of Xuebijing were reported.

Conclusions: Standard treatment combined with Xuebijing injection can significantly improve the PSI risk score and clinical prognosis of patients with severe COVID-19 without increasing drug safety risk.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3760/cma.j.cn121430-20210514-00714DOI Listing
July 2021

Clinical characteristics and outcomes of critically ill patients with coronavirus disease 2019 with hypotension in China: a retrospective cohort study.

Ann Palliat Med 2021 Aug 5;10(8):8536-8546. Epub 2021 Aug 5.

Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, China.

Background: The characteristics of the coronavirus disease 2019 (COVID-19) patients with hypotension are still limited. We aim to describe the clinical features and outcomes of the patients.

Methods: This was a multicenter retrospective study of critically ill patients with COVID-19 from ICUs in 19 hospitals in China. All patients were followed up to day 28 or death, which came first. Clinical and outcome data were collected and analyzed. Patients were classified as early-onset or late-onset hypotension, and clinical characteristics and outcomes were compared.

Results: A total of 649 patients were included in the final analysis, and 240 (37.0%) were hypotension patients. The median age of hypotension patients was 67 years (IQR, 60-73 years), and 159 (66.2%) were male. 172 (71.7%) of the hypotension patients had at least one comorbidity. The 28-day mortality of the patients with hypotension was 85.4%, which was significantly higher than that of patients without hypotension. Compared with late-onset hypotension patients, the 28-day mortality of patients with early-onset hypotension was significantly higher (90.1% vs. 78.6%, P=0.02).

Conclusions: Approximately one third critically ill COVID-19 patients progressed to hypotension. The mortality was significantly higher in hypotension patients than that in patients without hypotension. Compared with patients with late-onset hypotension, the mortality of patients with early-onset hypotension was significantly higher.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.21037/apm-20-2172DOI Listing
August 2021

Progressive Stabilization of Brain Network Dynamics during Childhood and Adolescence.

Cereb Cortex 2021 Aug 10. Epub 2021 Aug 10.

State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing 100875, China.

Functional brain networks require dynamic reconfiguration to support flexible cognitive function. However, the developmental principles shaping brain network dynamics remain poorly understood. Here, we report the longitudinal development of large-scale brain network dynamics during childhood and adolescence, and its connection with gene expression profiles. Using a multilayer network model, we show the temporally varying modular architecture of child brain networks, with higher network switching primarily in the association cortex and lower switching in the primary regions. This topographical profile exhibits progressive maturation, which manifests as reduced modular dynamics, particularly in the transmodal (e.g., default-mode and frontoparietal) and sensorimotor regions. These developmental refinements mediate age-related enhancements of global network segregation and are linked with the expression profiles of genes associated with the enrichment of ion transport and nucleobase-containing compound transport. These results highlight a progressive stabilization of brain dynamics, which expand our understanding of the neural mechanisms that underlie cognitive development.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1093/cercor/bhab263DOI Listing
August 2021

LPS-Induced Inflammation Affects Midazolam Clearance in Juvenile Mice in an Age-Dependent Manner.

J Inflamm Res 2021 3;14:3697-3706. Epub 2021 Aug 3.

Department of Clinical Pharmacy, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, 250012, People's Republic of China.

Purpose: Inflammation has a significant impact on CYP3A activity. We hypothesized that this effect might be age dependent. Our objective was to conduct a population pharmacokinetic study of midazolam in mice at different developmental stages with varying degrees of inflammation to verify our hypothesis.

Methods: Different doses (2 and 5 mg/kg) of lipopolysaccharide (LPS) were used to induce different degrees of systemic inflammation in Swiss mice (postnatal age 9-42 days, n = 220). The CYP3A substrate midazolam was selected as the pharmacological probe to study CYP3A activity. Postnatal age, current body weight, serum amyloid A protein 1 (SAA1) levels and LPS doses were collected as covariates to perform a population pharmacokinetic analysis using NONMEM 7.2.

Results: A population pharmacokinetic model of midazolam in juvenile and adult mice was established. Postnatal age and current body weight were the most significant and positive covariates for clearance and volume of distribution. LPS dosage was the most significant and negative covariate for clearance. LPS dosage can significantly reduce the clearance of midazolam by 21.8% and 38.7% with 2 mg/kg and 5 mg/kg, respectively. Moreover, the magnitude of the reduction was higher in mice with advancing postnatal age.

Conclusion: Both inflammation and ontogeny have an essential role in CYP3A activity in mice. The effect of LPS-induced systemic inflammation on midazolam clearance in mice is dependent on postnatal age.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.2147/JIR.S321492DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8349217PMC
August 2021

Evaluation of Positive End-Expiratory Pressure Strategies in Patients With Coronavirus Disease 2019-Induced Acute Respiratory Distress Syndrome.

Front Med (Lausanne) 2021 20;8:637747. Epub 2021 Jul 20.

Jiangsu Provincial Key Laboratory of Critical Care Medicine, Department of Critical Care Medicine, School of Medicine, Zhongda Hospital, Southeast University, Nanjing, China.

Different positive end-expiratory pressure (PEEP) strategies are available for subjects with coronavirus disease 2019 (COVID-19)-induced acute respiratory distress syndrome (ARDS) requiring invasive mechanical ventilation. We aimed to evaluate three conventional PEEP strategies on their effects on respiratory mechanics, gas exchanges, and hemodynamics. This is a prospective, physiologic, multicenter study conducted in China. We recruited 20 intubated subjects with ARDS and confirmed COVID-19. We first set PEEP by the ARDSnet low PEEP-fraction of inspired oxygen (FIO) table. After a recruitment maneuver, PEEP was set at 15, 10, and 5 cm HO for 10 min, respectively. Among these three PEEP levels, best-compliance PEEP was the one providing the highest respiratory system compliance; best-oxygenation PEEP was the one providing the highest PaO (partial pressure of arterial oxygen)/FIO. At each PEEP level, we assessed respiratory mechanics, arterial blood gas, and hemodynamics. Among three PEEP levels, plateau pressure, driving pressure, mechanical power, and blood pressure improved with lower PEEP. The ARDSnet low PEEP-FIO table and the best-oxygenation strategies provided higher PEEP than the best-compliance strategy (11 ± 6 cm HO vs. 11 ± 3 cm HO vs. 6 ± 2 cm HO, = 0.001), leading to higher plateau pressure, driving pressure, and mechanical power. The three PEEP strategies were not significantly different in gas exchange. The subgroup analysis showed that three PEEP strategies generated different effects in subjects with moderate or severe ARDS ( = 12) but not in subjects with mild ARDS ( = 8). In our cohort with COVID-19-induced ARDS, the ARDSnet low PEEP/FIO table and the best-oxygenation strategies led to higher PEEP and potentially higher risk of ventilator-induced lung injury than the best-compliance strategy. www.ClinicalTrials.gov, identifier: NCT04359251.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3389/fmed.2021.637747DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8329249PMC
July 2021

Driving Pressure Is a Risk Factor for ARDS in Mechanically Ventilated Subjects Without ARDS.

Respir Care 2021 Oct 3;66(10):1505-1513. Epub 2021 Aug 3.

Ciber Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain.

Background: Driving pressure (ΔP) has been described as a risk factor for mortality in patients with ARDS. However, the role of ΔP in the outcome of patients without ARDS and on mechanical ventilation has received less attention. Our objective was to evaluate the association between ΔP on the first day of mechanical ventilation with the development of ARDS.

Methods: This was a post hoc analysis of a multicenter, prospective, observational, international study that included subjects who were on mechanical ventilation for > 12 h. Our objective was to evaluate the association between ΔP on the first day of mechanical ventilation with the development of ARDS. To assess the effect of ΔP, a logistic regression analysis was performed when adjusting for other potential risk factors. Validation of the results obtained was performed by using a bootstrap method and by repeating the same analyses at day 2.

Results: A total of 1,575 subjects were included, of whom 65 (4.1%) developed ARDS. The ΔP was independently associated with ARDS (odds ratio [OR] 1.12, 95% CI 1.07-1.18 for each cm HO of ΔP increase, < .001). The same results were observed at day 2 (OR 1.14, 95% CI 1.07-1.21; < .001) and after bootstrap validation (OR 1.13, 95% CI 1.04-1.22; < .001). When taking the prevalence of ARDS in the lowest quartile of ΔP (≤9 cm HO) as a reference, the subjects with ΔP > 12-15 cm HO and those with ΔP > 15 cm HO presented a higher probability of ARDS (OR 3.65, 95% CI 1.32-10.04 [ = .01] and OR 7.31, 95% CI, 2.89-18.50 [ < .001], respectively).

Conclusions: In the subjects without ARDS, a higher level of ΔP on the first day of mechanical ventilation was associated with later development of ARDS. (ClinicalTrials.gov registration NCT02731898.).
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.4187/respcare.08587DOI Listing
October 2021

Rational Design of Self-Supported CuO -Decorated Composite Films as an Efficient and Easy-Recycling Catalyst for Styrene Oxidation.

ACS Omega 2021 Jul 6;6(28):18157-18168. Epub 2021 Jul 6.

School of Chemistry, Tiangong University, 399 Binshui West Road, Tianjin 300387, China.

The applications of graphene-based materials in catalysis are limited by their strong tendency to aggregate, which may lead to a decrease in active sites. Herein, we propose a facile and controllable strategy to fabricate a series of heterogeneous catalysts with a unique nanostructure wherein CuO -decorated reduced graphene oxide (rGO) sheets are incorporated into a solid matrix composed of poly(vinylpyrrolidone) (PVP) and carboxymethyl cellulose (CMC). The resultant materials are self-supported films and could be directly used as catalysts for the liquid-phase oxidation of styrene without the requirement for extra substrates. The employment of PVP-CMC (PC) as the support for CuO -decorated rGO sheets successfully inhibits their aggregation. Benefiting from the dispersion of copper species, these films exhibit good catalytic activity and recyclability under mild reaction conditions. Especially, they can be conveniently removed from the reaction mixture by tweezers due to their structural stability. For catalyzing multiple reactions with high efficiency and facile recyclability, this study offers a universal strategy to design heterogeneous catalysts based on graphene materials and provides a promising platform.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsomega.1c02031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8296588PMC
July 2021

COVID-19.

Stem Cell Res 2021 08 17;55:102468. Epub 2021 Jul 17.

State Key Laboratory of Rare, Complex and Critical Diseases, Medical ICU, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, 1 Shuai Fu Yuan, Beijing 100730, China. Electronic address:

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.scr.2021.102468DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8285209PMC
August 2021

[Effect of high-flow nasal cannula oxygen on patients with chronic obstructive pulmonary disease and mild hypercapnia: a retrospective cohort study based on the Medical Information Mart for Intensive Care-IV database].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2021 Jun;33(6):686-691

Department of Medical ICU, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100730, China. Corresponding author: Du Bin, Email:

Objective: To observe the effect of high-flow nasal cannula oxygen therapy (HFNC) in patients with chronic obstructive pulmonary disease (COPD) and mild hypercapnia, and to evaluate the early predictive ability of physiological parameters in these patients.

Methods: A retrospective cohort study was conducted based on Medical Information Mart for Intensive Care-IV (MIMIC-IV) updated in September 2020 and the data of adult patients with COPD and mild hypercapnia [45 mmHg (1 mmHg = 0.133 kPa) < arterial partial pressure of carbon dioxide (PaCO) ≤ 60 mmHg] from 2008 to 2019 were collected. These patients were assigned to the HFNC group or non-invasive ventilation (NIV) group according to whether they received HFNC or NIV. Baseline data such as gender, age, body mass index (BMI), simplified acute physiology score II (SAPS II), Charlson comorbidity index (CCI) and physiological parameters were collected. A propensity score matching was conducted according to the baseline data of the HFNC group patients. The 48-hour and 28-day intubation rates, 28-day mortality, length of intensive care unit (ICU) stay, the length of hospital stay, and the changes in physiological parameters within 48 hours after treatment were compared between the two groups. The receiver operating characteristic curve (ROC curve) was drawn and the ratio of heart rate over pulse oxygen saturation (HR/SpO) and ROX index [SpO/(inhaled oxygen concentration, FiO×respiratory rate, RR)] were analyzed to predict the 24-hour and 48-hour intubation rates.

Results: A total of 524 520 inpatient records were screened and 153 patients were included, while 37 patients in the HFNC group and 116 patients in NIV group. There were 31 patients in the HFNC group and 84 patients in the NIV group remained after propensity score matching according to the baseline data. There were no significant differences in the baseline data of gender, age, BMI, SAPS II, CCI score, physiological parameters and prognosis data except the length of ICU stay. The length of ICU stay in HFNC group was significant longer than that of the NIV group [days: 4.6 (3.1, 10.0) vs. 3.1 (1.6, 5.8), P < 0.05]. HR and RR at 40-48 hours were significantly lower than those at 0-8 hours after treatment only in the HFNC group [HR (bpm): 84.1±12.2 vs. 91.1±16.4, RR (times/min): 19.8±4.9 vs. 21.6±4.1, both P < 0.05]. Both in the HFNC group and NIV group the pH increased (7.42±0.08 vs. 7.36±0.05 and 7.41±0.06 vs. 7.36±0.05, both P < 0.05) and PaCO decreased significantly [mmHg: 46.3 (39.5, 51.0) vs. 49.8 (45.5, 54.0) and 46.0 (40.5, 51.5) vs. 49.5 (45.5, 55.3), both P < 0.05]. The HR, PaO were higher in the HFNC group than those in the HFNC group at 40-48 hours after treatment [HR (bpm): 91.1±15.4 vs. 84.1±12.2, PaO (mmHg): 99.5 (86.0, 132.3) vs. 85.8 (76.5, 118.0), both P < 0.05], PaO/FiO were lower in the HFNC group than that in the HFNC group at 40-48 hours after treatment [mmHg: 223.8 (216.5, 285.0) vs. 278.0 (212.3, 306.0), P < 0.05]. Both HR/SpO and ROX index at 4 hours after treatment had predictive value for 24-hour and 48-hour intubation in the HFNC group. The areas under ROC curve (AUC) of HR/SpO at 4 hours after treatment in the HFNC group were larger than those of ROX index for predicting 24-hour and 48-hour intubation (24-hour: 0.649 vs. 0.574, 48-hour: 0.692 vs. 0.581, both P < 0.01); the 95% confidence interval (95%CI) of 4 hours HR/SpO and for ROX index predicting 24 hours and 48 hours intubation were 0.497-0.780, 0.567-0.799, 0.450-0.694 and 0.454-0.716, respectively. The high sensitivity of HR/SpO and ROX index in predicting 24-hour and 48-hour intubation were 84.6%, 92.9%, 88.2% and 94.4%, respectively, and the low specificity were 52.3%, 23.7%, 54.7% and 29.6%, respectively.

Conclusions: HFNC can be used in COPD patients with mild hypercapnia, but it cannot replace NIV. The accuracy of ROX index at 4 hours after HFNC treatment in predicting intubation in COPD patients with mild hypercapnia is poor.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3760/cma.j.cn121430-20210219-00258DOI Listing
June 2021

Conservative oxygen therapy for critically ill patients: a meta-analysis of randomized controlled trials.

J Intensive Care 2021 Jul 22;9(1):47. Epub 2021 Jul 22.

Medical ICU, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, 1 Shuai Fu Yuan, Beijing, 100730, China.

Objective: Conservative oxygen strategy is recommended in acute illness while its benefit in ICU patients remains controversial. Therefore, we sought to conduct a systematic review and meta-analysis to examine such oxygen strategies' effect and safety in ICU patients.

Methods: We searched PubMed, Embase, and the Cochrane database from inception to Feb 15, 2021. Randomized controlled trials (RCTs) that compared a conservative oxygen strategy to a conventional strategy in critically ill patients were included. Results were expressed as mean difference (MD) and risk ratio (RR) with a 95% confidence interval (CI). The primary outcome was the longest follow-up mortality. Heterogeneity, sensitivity analysis, and publication bias were also investigated to test the robustness of the primary outcome.

Results: We included seven trials with a total of 5265 patients. In general, the conventional group had significantly higher SpO or PaO than that in the conservative group. No statistically significant differences were found in the longest follow-up mortality (RR, 1.03; 95% CI, 0.97-1.10; I=18%; P=0.34) between the two oxygen strategies when pooling studies enrolling subjects with various degrees of hypoxemia. Further sensitivity analysis showed that ICU patients with mild-to-moderate hypoxemia (PaO/FiO >100 mmHg) had significantly lower mortality (RR, 1.24; 95% CI, 1.05-1.46; I=0%; P=0.01) when receiving conservative oxygen therapy. These findings were also confirmed in other study periods. Additional, secondary outcomes of the duration of mechanical ventilation, the length of stay in the ICU and hospital, change in sequential organ failure assessment score, and adverse events were comparable between the two strategies.

Conclusions: Our findings indicate that conservative oxygen therapy strategy did not improve the prognosis of the overall ICU patients. The subgroup of ICU patients with mild to moderate hypoxemia might obtain prognosis benefit from such a strategy without affecting other critical clinical results.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40560-021-00563-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8295978PMC
July 2021

Machine Learning Prediction Models for Mechanically Ventilated Patients: Analyses of the MIMIC-III Database.

Front Med (Lausanne) 2021 1;8:662340. Epub 2021 Jul 1.

Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China.

Mechanically ventilated patients in the intensive care unit (ICU) have high mortality rates. There are multiple prediction scores, such as the Simplified Acute Physiology Score II (SAPS II), Oxford Acute Severity of Illness Score (OASIS), and Sequential Organ Failure Assessment (SOFA), widely used in the general ICU population. We aimed to establish prediction scores on mechanically ventilated patients with the combination of these disease severity scores and other features available on the first day of admission. A retrospective administrative database study from the Medical Information Mart for Intensive Care (MIMIC-III) database was conducted. The exposures of interest consisted of the demographics, pre-ICU comorbidity, ICU diagnosis, disease severity scores, vital signs, and laboratory test results on the first day of ICU admission. Hospital mortality was used as the outcome. We used the machine learning methods of -nearest neighbors (KNN), logistic regression, bagging, decision tree, random forest, Extreme Gradient Boosting (XGBoost), and neural network for model establishment. A sample of 70% of the cohort was used for the training set; the remaining 30% was applied for testing. Areas under the receiver operating characteristic curves (AUCs) and calibration plots would be constructed for the evaluation and comparison of the models' performance. The significance of the risk factors was identified through models and the top factors were reported. A total of 28,530 subjects were enrolled through the screening of the MIMIC-III database. After data preprocessing, 25,659 adult patients with 66 predictors were included in the model analyses. With the training set, the models of KNN, logistic regression, decision tree, random forest, neural network, bagging, and XGBoost were established and the testing set obtained AUCs of 0.806, 0.818, 0.743, 0.819, 0.780, 0.803, and 0.821, respectively. The calibration curves of all the models, except for the neural network, performed well. The XGBoost model performed best among the seven models. The top five predictors were age, respiratory dysfunction, SAPS II score, maximum hemoglobin, and minimum lactate. The current study indicates that models with the risk of factors on the first day could be successfully established for predicting mortality in ventilated patients. The XGBoost model performs best among the seven machine learning models.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3389/fmed.2021.662340DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8280779PMC
July 2021

Improved Auditory Function Caused by Music Versus Foreign Language Training at School Age: Is There a Difference?

Cereb Cortex 2021 Jul 16. Epub 2021 Jul 16.

State Key Laboratory of Cognitive Neuroscience and Learning and IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China.

In adults, music and speech share many neurocognitive functions, but how do they interact in a developing brain? We compared the effects of music and foreign language training on auditory neurocognition in Chinese children aged 8-11 years. We delivered group-based training programs in music and foreign language using a randomized controlled trial. A passive control group was also included. Before and after these year-long extracurricular programs, auditory event-related potentials were recorded (n = 123 and 85 before and after the program, respectively). Through these recordings, we probed early auditory predictive brain processes. To our surprise, the language program facilitated the children's early auditory predictive brain processes significantly more than did the music program. This facilitation was most evident in pitch encoding when the experimental paradigm was musically relevant. When these processes were probed by a paradigm more focused on basic sound features, we found early predictive pitch encoding to be facilitated by music training. Thus, a foreign language program is able to foster auditory and music neurocognition, at least in tonal language speakers, in a manner comparable to that by a music program. Our results support the tight coupling of musical and linguistic brain functions also in the developing brain.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1093/cercor/bhab194DOI Listing
July 2021

Association of fluid balance trajectories with clinical outcomes in patients with septic shock: a prospective multicenter cohort study.

Mil Med Res 2021 07 6;8(1):40. Epub 2021 Jul 6.

Department of Critical Care Medicine, Fuxing Hospital, Capital Medical University, No. 20, Street Fuxingmenwai, Beijing, Xicheng District, China.

Background: Septic shock has a high incidence and mortality rate in Intensive Care Units (ICUs). Earlier intravenous fluid resuscitation can significantly improve outcomes in septic patients but easily leads to fluid overload (FO), which is associated with poor clinical outcomes. A single point value of fluid cannot provide enough fluid information. The aim of this study was to investigate the impact of fluid balance (FB) latent trajectories on clinical outcomes in septic patients.

Methods: Patients were diagnosed with septic shock during the first 48 h, and sequential fluid data for the first 3 days of ICU admission were included. A group-based trajectory model (GBTM) which is designed to identify groups of individuals following similar developmental trajectories was used to identify latent subgroups of individuals following a similar progression of FB. The primary outcomes were hospital mortality, organ dysfunction, major adverse kidney events (MAKE) and severe respiratory adverse events (SRAE). We used multivariable Cox or logistic regression analysis to assess the association between FB trajectories and clinical outcomes.

Results: Nine hundred eighty-six patients met the inclusion criteria and were assigned to GBTM analysis, and three latent FB trajectories were detected. 64 (6.5%), 841 (85.3%), and 81 (8.2%) patients were identified to have decreased, low, and high FB, respectively. Compared with low FB, high FB was associated with increased hospital mortality [hazard ratio (HR) 1.63, 95% confidence interval (CI) 1.22-2.17], organ dysfunction [odds ratio (OR) 2.18, 95% CI 1.22-3.42], MAKE (OR 1.80, 95% CI 1.04-2.63) and SRAE (OR 2.33, 95% CI 1.46-3.71), and decreasing FB was significantly associated with decreased MAKE (OR 0.46, 95% CI 0.29-0.79) after adjustment for potential covariates.

Conclusion: Latent subgroups of septic patients followed a similar FB progression. These latent fluid trajectories were associated with clinical outcomes. The decreasing FB trajectory was associated with a decreased risk of hospital mortality and MAKE.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1186/s40779-021-00328-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8258941PMC
July 2021

Preparation of the Temperature-Responsive Superhydrophobic Paper with High Stability.

ACS Omega 2021 Jun 8;6(24):16016-16028. Epub 2021 Jun 8.

Faculty of Printing, Packaging Engineering and Digital Media Technology, Xi'an University of Technology, Xi'an 710048, P. R. China.

In this paper, a method for preparing a high-stability superhydrophobic paper with temperature-induced wettability transition is proposed. First, a temperature-responsive superhydrophobic triblock polymer PHFMA-PTSPM-PNIPAAm was prepared by one-step polymerization of TSPM, HFMA, and NIPAAm in a mass ratio of 0.3:0.3:0.3, then a superhydrophobic paper with a good temperature response was successfully prepared by grafting amino-modified SiO with the polymer to modify the surface of the paper. A further study found that when the mass ratio of amino-modified SiO to polymer is 0.2, the coating has good superhydrophobicity and transparency. What is more, the prepared modified paper is in a superhydrophobic state when the temperature is higher than 32 °C, and is in a superhydrophilic state when it is lower than 32 °C, which can realize free conversion between superhydrophobic and superhydrophilic states. In addition, the superhydrophobic paper prepared by this method not only has high oil-water separation efficiency, and the superhydrophobic coating shows good stability and transparency, but also has low requirements of environmental conditions for preparation, relatively simple preparation process, and strong repeatability, and it has a very broad application prospect.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsomega.1c01861DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8223434PMC
June 2021

Critical care after the COVID-19 outbreak in China: lessons and renaissance.

Intensive Care Med 2021 09 22;47(9):1017-1020. Epub 2021 Jun 22.

Jiangsu Provincial Key Laboratory of Critical Care Medicine, Department of Critical Care Medicine, School of Medicine, Zhongda Hospital, Southeast University, Nanjing, 210009, China.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00134-021-06447-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8217202PMC
September 2021

Predictive value of change in effective arterial elastance in norepinephrine weaning: a retrospective study.

Ann Palliat Med 2021 Jun 7;10(6):6325-6335. Epub 2021 Jun 7.

Medical Intensive Care Unit, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.

Background: The weaning of vasopressors is usually an empirical choice made by clinicians. The aim of this study is to assess the predictive value of change in effective arterial elastance (ΔEa%) induced by fluid administration in early initiation of norepinephrine (NE) weaning.

Methods: Included were intensive care unit (ICU) septic shock patients with an indwelling pulmonary artery catheter who experienced initial resuscitation and required a fluid challenge. Reduced norepinephrine dose or maintained steady (ΔNE ≤0 μg/min) at 6 hours after inclusion (T6) was defined as early initiation of norepinephrine weaning. Univariate and multivariate analyses were performed to assess ΔEa% viability and other hemodynamic parameters in predicting the possibility of norepinephrine weaning. A receiver operating characteristic (ROC) analysis was used to confirm model predictions.

Results: One hundred and eight patients were assessed. Of 108 patients, 75 (69.4%) constituted the NE weaning group at T6. The multivariate analysis showed that ΔEa% [odds ratios (OR): 0.95; 95% confidence interval (CI): 0.89-0.99; P=0.003] was an independent predictive factor for norepinephrine weaning at T6. ROC analysis confirmed that ΔEa% was associated with norepinephrine weaning [area under ROC curve (AUC) at 0.64; 95% CI: 0.52-0.75; P=0.026]. To predict norepinephrine weaning, the optimum threshold for ΔEa% was 5.1% (sensitivity: 61%, specificity: 67%). Notably, the combination of ΔEa%, change in systemic vascular resistance (ΔSVR%) and change in cardiac output (ΔCO%) strengthened the predictive ability with an AUC at 0.73 (95% CI: 0.64-0.83; P=0.001). Median (interquartile range) duration (in hours) of norepinephrine was significantly shorter in the NE weaning group compared with the NE worsening group {48 [34-89] vs. 72 [54-90] hours, P=0.048}.

Conclusions: Change in effective arterial elastance induced by fluid administration may assist clinicians in detecting patients who is possible to initiate norepinephrine weaning. Early initiation of norepinephrine weaning was associated with shorter duration of norepinephrine exposure.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.21037/apm-21-482DOI Listing
June 2021

[Epidemiological analysis of jellyfish stings in coastal bathing beaches in Qinhuangdao City from 2017 to 2019].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2021 May;33(5):593-595

Department of Emergency, the First Hospital of Qinhuangdao, Qinhuangdao 066000, Hebei, China.

Objective: To analyze the distribution and composition characteristics of jellyfish stings in various coastal baths in Qinhuangdao City from 2017 to 2019, and to provide scientific basis for the prevention, control and early warning of jellyfish stings.

Methods: Statistics and analysis of the age, gender, time of stings, location of injury, first symptoms, and playing time in the sea at the time of the sting, etc. of people with jellyfish stings in various bathing beaches along the coast of Qinhuangdao from 2017 to 2019 (July to August) were conducted.

Results: The number of jellyfish stings in the coastal bathing beaches of Qinhuangdao City in 2017, 2018, and 2019 was decreasing year by year, with 1 890, 492, and 171 cases respectively. Among them, Qianshuiwan Bathing Beach and Dongshan Bathing Beach had more stings (60.90% and 35.08% respectively in 2017, 24.39% and 64.23% respectively in 2018, 16.96% and 16.42% respectively in 2019). There was no significant change in the gender and age distribution of jellyfish stings each year [57.99% males in 2017, with a median age of 13 (8, 31) years old; 63.21% males in 2018, with a median age of 25 (8, 29) years old; and 59.65% males in 2019, with a median age of 12 (7, 31) years old]. Stings were mainly located at the lower limbs (the proportion of lower limb injuries: 46.54% in 2018, 45.61% in 2019), followed by upper limbs (upper arm, elbow, forearm), trunk, etc. The first symptom was mainly pain (89.43% in 2018, 38.29% in 2019), followed by rash (64.43% in 2018, 59.43% in 2019), numbness, blisters, etc. Sting incidents mainly occurred from 13:00 to 17:59 (the proportion of sting incidents in this time period in 2018 and 2019 were 68.09% and 52.63%, respectively).

Conclusions: Jellyfish stings in coastal baths in Qinhuangdao City are mainly distributed in Qianshuiwan Baths and Dongshan Baths. The management of these sea areas should be strengthened, and scientific publicity and medical rescue should be strengthened to prevent jellyfish stings in peak hours and related baths.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3760/cma.j.cn121430-20210123-00103DOI Listing
May 2021

Correction to: Efects of high-flow oxygen therapy on patients with hypoxemia after extubation and predictors of reintubation: a retrospective study based on the MIMIC-IV database.

BMC Pulm Med 2021 Jun 9;21(1):194. Epub 2021 Jun 9.

Department of Medical Intensive Care Unit, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, 1 Shuai Fu Yuan, Beijing, 100730, China.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12890-021-01562-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8188675PMC
June 2021

Assessment of a novel aminated magnetic adsorbent with excellent adsorption capacity for dyes and drugs.

J Environ Manage 2021 Sep 1;293:112809. Epub 2021 Jun 1.

College of Civil Engineering, Sichuan Agricultural University, Chengdu, 611830, China.

Dyes and drugs with high toxicity and low biodegradability pose risk to human health and ecological security, and should be purified efficiently from effluents before discharge. Traditional adsorbents are limited by the insufficient active adsorption sites and low stability. In this study, a novel aminated magnetic adsorbent (MCTs) was fabricated via two cross-linking steps using chitosan and triethylenetetramine to fill the gaps between current adsorbent and performance requirements. The morphological and physicochemical characteristics of the as-prepared MCTs were determined and identified with the aid of several characterization techniques. The adsorption performance of dyes and drugs was also investigated and represented by their adsorption capacities. In particular, the adsorption capacities of Congo Red, Chicago Sky Blue, Reactive Brilliant Red, and Ibuprofen were 583.11, 465.01, 403.12, and 291.71 mg/g, respectively. They also remained at around 80% after four reuse cycles. MCTs were adsorbed via a monolayer spontaneous chemical reaction, and hydrogen bonding and electrostatic interaction were the dominant adsorption mechanisms. These results demonstrated that the preparation of MCTs via two cross-linking steps enhanced the adsorbents' adsorption capacity, reusability, and stability. They provided a new perspective for the preparation of high-efficient adsorbents and the purification of dye- and drug-polluted wastewater.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jenvman.2021.112809DOI Listing
September 2021

Downregulation of Renal MRPs Transporters in Acute Lymphoblastic Leukemia Mediated by the IL-6/STAT3/PXR Signaling Pathway.

J Inflamm Res 2021 25;14:2239-2252. Epub 2021 May 25.

Department of Clinical Pharmacy, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, People's Republic of China.

Purpose: Considering prior investigations on reductions of renal multidrug resistance-associated protein (MRP) 2 and 4 transporters in mice with acute lymphoblastic leukemia (ALL), we sought to characterize the underlying mechanisms responsible for IL-6/STAT3/PXR-mediated changes in the expression of MRP2 and MRP4 in ALL.

Subjects And Methods: ALL xenograft models were established and intravenously injected with methotrexate (MTX) of MRPs substrate in NOD/SCID mice. Protein expression of MRPs and associated mechanisms were detected by Western blotting and immunocytochemistry. Plasma concentrations of MTX were determined using high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS).

Results: Plasma IL-6 levels in patients with newly diagnosed ALL were increased compared to children with pneumonia. Similarly, plasma IL-6 levels in ALL, ALL-tocilizumab (TCZ, an IL-6 receptor inhibitor) and ALL-S3I-201 (a selective inhibitor of STAT3) mice were increased compared to the control group. The MRP2, MRP4, and PXR expression in HK-2 cells treated with IL-6 were decreased, whereas the p-STAT3 expression was significantly increased compared to the control group results. These results are consistent with clearance of MRPs-mediated MTX in the ALL group. These effects were attenuated by blocking IL-6/STAT3/PXR signaling pathway.

Conclusion: Inflammation-mediated changes in pharmacokinetics are thought to be executed through pathways IL-6-activated pathways, which can facilitate a better understanding of the potential for the use of IL-6 to predict the severity of adverse outcomes and the major implications on potential ALL treatments.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.2147/JIR.S310687DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8164703PMC
May 2021

Pathogenesis and Function of Interleukin-35 in Rheumatoid Arthritis.

Front Pharmacol 2021 13;12:655114. Epub 2021 May 13.

Second Hospital of Anhui Medical University, Hefei, China.

It is well known that RA (Rheumatoid arthritis) is an autoimmune disease characterized by multiple and symmetric arthropathy. The main pathological features of RA are synovial hyperplasia, angiogenesis, pannus formation, inflammatory cell infiltration, articular cartilage, bone destruction, and ultimately joint dysfunction, even deformity. IL-35 (Interleukin-35) is a new member of the IL-12 (Interleukin-12) family, which is an immunosuppressive and anti-inflammatory cytokine secreted mainly by Treg (T regulatory cells). There is evidence suggested that IL-35 can attenuate the progression of RA through influencing the immune and pathological process. It suggests that IL-35 played an important role in the pathogenesis of RA, and can be used as a potential target for the future treatment of RA. This review summarizes the recent advances of IL-35 in the pathological roles and the therapeutic potential roles in RA.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3389/fphar.2021.655114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8155723PMC
May 2021

Plant sprout foods: Biological activities, health benefits, and bioavailability.

J Food Biochem 2021 May 28:e13777. Epub 2021 May 28.

Hebei Key Laboratory of Active Components and Functions in Natural Products, Hebei Normal University of Science and Technology, Hebei, China.

Plant sprout foods exhibit a lot of biological activities including anti-inflammatory, antioxidative, anticancer, antidiabetes, anti-infection, and antiviral activities. Up to the present moment, plant sprout foods have received much attention due to their abundance, good bioavailability, and health benefits for human. This review highlights the biological activities of different plant sprout foods (viz., broccoli sprout, buckwheat sprout, wheat sprout, mung bean sprout, soybean sprout, and adkuzi bean sprout) using in vitro model, animal model, and human model. Furthermore, the bioavailability of plant sprout foods is also discussed. PRACTICAL APPLICATIONS: A review of the literature was conducted to biological activities of plant sprout foods, in addition to a summary of health benefits and bioavailability of sprout foods. Several biological activities of plant sprout foods with in vitro and in vivo evidence are currently unexplored in clinical trials, because the effects of sprout foods on human tissues and cells measured by tube test do not recapitulate the actual in vivo effects. Moreover, the safety of chemoprevention strategies using sprout foods that to protect against environmental exposures and other oxidative stress-related pathologies is important. Further research is warranted to evaluate bioavailability of individual forms.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1111/jfbc.13777DOI Listing
May 2021

Enhancing Dielectric Strength of Epoxy Polymers by Constructing Interface Charge Traps.

ACS Appl Mater Interfaces 2021 Jun 26;13(22):25850-25857. Epub 2021 May 26.

School of Electrical Engineering and Automation, Hefei University of Technology, Hefei 230009, P. R. China.

Epoxy polymer-based dielectric materials play a crucial role in advanced electronic devices and power equipment. However, high voltage-stress applications impose stringent requirements, such as a high dielectric strength, on epoxy polymers. Previously reported studies have shown promising material architectures in the form of epoxy polymer-nanoparticle dielectrics, which can restrict the movement of high-energy electrons by the interface charge traps associated with the various interfacial regions. However, these high-energy electrons inevitably traverse the epoxy polymer matrix and destroy the molecular structure, thereby creating a weak link for dielectric breakdown. In this study, a general strategy is developed to improve the dielectric strength by constructing interface charge traps in the molecular structure of the epoxy polymer matrix, using the -CF group in partial replacement of the -CH group. The proposed strategy increases the dielectric strength (39.5 kV mm) and surface breakdown voltage (26.9 kV) of the epoxy polymer matrix by 22.08% and 13.3%, respectively, because the interface charge trap hinders the movement of high-energy electrons. At the same time, the strategy does not degrade the mechanical and thermal properties. The results hold potential for wide application in the manufacturing of advanced future electrical and electronic equipment requiring resilience to high-voltage stress.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsami.1c01933DOI Listing
June 2021

Recurrent perimesencephalic nonaneurysmal subarachnoid hemorrhage within a short period of time: A case report.

World J Clin Cases 2021 May;9(14):3356-3364

Department of Neurosurgery, Jinan Central Hospital Affiliated to Shandong First Medical University, Jinan 250000, Shandong Province, China.

Background: Spontaneous subarachnoid hemorrhage (SAH) is primarily caused by a ruptured intracranial aneurysm. Perimesencephalic nonaneurysmal SAH (PNSAH) accounts for approximately 5% of all spontaneous SAH. PNSAH displays favorable prognosis. The risk of hemorrhage recurrence is low. We report a case of PNSAH recurrence, occurring within a short time after the initial episode in a patient not receiving antithrombotic or antiplatelet drugs.

Case Summary: A 66-year-old male, without any history of recent trauma or antithrombotic/ antiplatelet medication, suffered two similar episodes of sudden onset of severe headache, nausea, and vomiting. A plain head computed tomography (CT) scan showed subarachnoid blood confined to the anterior part of the brainstem. Platelet count and coagulation function were normal. PNSAH was diagnosed by repeated head CT, magnetic resonance imaging, and cerebral angiography, none of which revealed the source of SAH. The patient was discharged without focal neurological deficits. At 6-mo follow-up, the patient had experienced no sudden onset of severe headache and presented favorable clinical outcome. Studies have reported a few patients with recurrent PNSAH, originating frequently from venous hemorrhage and conventionally associated with venous abnormalities. PNSAH recurs within a short time following the initial onset of symptoms, although the possibility of re-hemorrhage is extremely rare.

Conclusion: PNSAH recurrence should arouse vigilance; however, the definite source of idiopathic SAH in this case report deserves further attention.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.12998/wjcc.v9.i14.3356DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8107889PMC
May 2021
-->