Publications by authors named "Bin Chen"

2,748 Publications

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Based on Network Pharmacology and Molecular Dynamics Simulations, Baicalein, an Active Ingredient of Yiqi Qingre Ziyin Method, Potentially Protects Patients With Atrophic Rhinitis From Cognitive Impairment.

Front Aging Neurosci 2022 10;14:880794. Epub 2022 Jun 10.

Department of Otorhinolaryngology Head and Neck Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Cognition may be improved by the active ingredients of the Yiqi Qingre Ziyin method in patients with atrophic rhinitis (AR). This study aimed to identify potential targets of the Yiqi Qingre Ziyin method for the treatment of patients with cognitive impairment. Nasal mucosal tissue samples from patients with AR were subjected to proteomic assays, and differentially expressed proteins were obtained. To explore the mechanism of AR leading to mild cognitive impairment (MCI), a differential analysis of AR related differential proteins in the MCI related GSE140831 dataset was performed. Most AR-related differential proteins are also differentially expressed in peripheral blood tissues of MCI, have similar biological functions and are enriched in similar pathways. These co-expressed differential factors in AR and MCI are known as common differential proteins of AR and MCI (CDPAM). Based on the analysis and validation of the random forest, support vector machine and neural network models, CDPAM acted as a diagnostic marker for MCI risk. Cytochrome C (CYCS) was significantly upregulated in the peripheral blood of patients with MCI. The active ingredients in the Yiqi Qingre Ziqin method were obtained and targeted 137 proteins. Among these targeted proteins, belong to the CDPAM set. Molecular docking and molecular dynamics analysis revealed that baicalein, an active ingredient in the Yiqi Qingre Ziyin method, stably targeted the CYCS protein. Results of the enrichment analysis revealed that the up-regulation of expression may have a defensive effect on the cells to resist foreign stimuli. Therefore, baicalein, an active ingredient in the Yiqi Qingre Ziyin method, may prevent the development and progression of MCI by targeting the CYCS protein.
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http://dx.doi.org/10.3389/fnagi.2022.880794DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9226445PMC
June 2022

Beyond green environments: Multi-scale difference in human exposure to greenspace in China.

Environ Int 2022 Jun 14;166:107348. Epub 2022 Jun 14.

Institute for Climate and Carbon Neutrality, The University of Hong Kong, Hong Kong Special Administrative Region; Department of Geography, and Department of Earth Science, The University of Hong Kong, Hong Kong Special Administrative Region.

Greenspace exposure metrics can allow for comparisons of green space supply across time, space, and population groups, and for inferring patterns of variation in opportunities for people to enjoy the health and recreational benefits of nearby green environments. A better understanding of greenspace exposure differences across various spatial scales is a critical requirement for lessening environmental health disparities. However, existing studies are typically limited to a single city or across selected cities, which severely limits the use of results in measuring systemic national and regional scale differences that might need policy at above individual city planning level. To close this knowledge gap, our study aims to provide a holistic assessment of multi-scale greenspace exposure across provinces, cities, counties, towns, and land parcels for the whole of China. We mapped the nationwide fractional greenspace coverage at 10 m with Sentinel-2 satellite imagery, and then modeled population-weighted greenspace exposure to examine variation of greenspace exposure across scales. Our results show a prominent scaling effect of greenspace exposure across multi-scale administrative divisions in China, suggesting, as expected, an increase in heterogeneity with finer spatial scales. We also identify an asymmetric pattern of the difference between greenspace exposure and greenspace coverage, across a geo-demographic demarcation boundary (i.e., along the Heihe-Tengchong Line). In general, the greenspace coverage rate will overestimate more realistic human exposure to greenspace in East China while underestimating in West China. We further found that, in China, more recently urbanized areas have much better greenspace exposure than older urban areas. Our study provides a spatially explicit greenspace exposure metric for discovering multi-scale greenspace exposure difference, which will enhance governments' capacity to quantify environmental justice, detect vulnerable greenspace exposure risk hotspots, prioritize greenspace management at the supra-city scale, and monitor the balance between greenspace supply and demand.
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http://dx.doi.org/10.1016/j.envint.2022.107348DOI Listing
June 2022

Light-assisted room temperature gas sensing performance and mechanism of direct Z-scheme MoS/SnO crystal faceted heterojunctions.

J Hazard Mater 2022 Aug 30;436:129246. Epub 2022 May 30.

Jiangxi Key Laboratory of Nanomaterials and Sensors, Jiangxi Key Laboratory of Photoelectronics and Telecommunication, School of Physics, Communication and Electronics, Jiangxi Normal University, Nanchang 330098, Jiangxi, PR China.

Light assistance and construction of heterojunctions are both promising means to improve the room temperature gas sensing performance of MoS recently. However, enhancing the separation efficiency of photo-generated carriers at interface and adsorption ability of surface have become the bottleneck problem to further improve the room temperature gas sensing performance of MoS-based heterojunctions under light assistance. In the present study, a novel direct Z-scheme MoSSnO heterojunction was designed through crystal facets engineering and its room temperature gas sensing properties under light assistance was studied. It was found that the heterojunction showed outstanding room temperature NO sensing performance with a high response of 208.66 toward 10 ppm NO together with excellent recovery characteristics and selectivity. The gas sensing mechanism study suggested that high-energy {221} crystal facets of SnO and MoS directly formed Z-scheme heterojunction, which could greatly improve the separation efficiency of photo-generated carriers with high redox capacity. Moreover, {221} facets greatly enhanced adsorption ability towards NO. This work not only opens up the application of Z-scheme heterojunctions in gas sensing, which will greatly promotes the development of room temperature light-assisted gas sensors, but also provides a new idea for the construction of direct Z-scheme heterojunctions through crystal facets engineering.
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http://dx.doi.org/10.1016/j.jhazmat.2022.129246DOI Listing
August 2022

First Comprehensive Analysis of Both Mitochondrial Characteristics and Mitogenome-Based Phylogenetics in the Subfamily Eumeninae (Hymenoptera: Vespidae).

Insects 2022 Jun 8;13(6). Epub 2022 Jun 8.

Chongqing Key Laboratory of Vector Insects, Chongqing Key Laboratory of Animal Biology, Institute of Entomology and Molecular Biology, College of Life Science, Chongqing Normal University, Chongqing 401331, China.

The subfamily Eumeninae plays a significant role in the biological control of agricultural pests. However, the characteristics of eumenine mitogenomes that are important molecular markers for phylogenetics are not clearly revealed. Here, 52 eumenine mitogenomes are newly sequenced and annotated, and the phylogenetic relationships of the subfamily are comprehensively analyzed based on 87 vespid mitogenomes. Through the comparative analysis of the 54 eumenine mitogenomes, the gene compositions of about one half of the 54 species match with ancestral insect mitogenome, and remaining others contain two which are highly similar, with 51.86% () to 90.65% () sequence identities, which is unique among the reported mitogenomes of the family Vespidae. Moreover, the translocation upstream of is a common rearrangement event in all eumenine mitogenomes. The results of phylogenetic analyses support the paraphyly of the subfamily Eumeninae and the tribe Odynerini, respectively, and the monophyly of the tribe Eumenini, and verify that the tribe Zethini is a valid subfamily Zethinae. In this study, the relationships between some genera such as and or the taxonomic status of the subgenera such as and are found to be confusing and there should be further inquiry with more samples.
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http://dx.doi.org/10.3390/insects13060529DOI Listing
June 2022

Treatment of Calcified Lumbar Disc Herniation by Intervertebral Foramen Remolding: A Retrospective Study.

J Pain Res 2022 16;15:1719-1728. Epub 2022 Jun 16.

Minimally Invasive Spine Surgery, Chengde Medical University Affiliated Hospital, Chengde, Hebei Province, People's Republic of China.

Purpose: This study aimed to investigate the use of the percutaneous intervertebral foramen lens technology for secondary molding of the intervertebral foramen in the treatment of calcified lumbar discs.

Methods: The study included 104 patients who were divided into two groups. Group A comprised 50 patients with calcified lumbar disc herniation and group B comprised 54 patients with non-calcified lumbar disc herniation diagnosed by computed tomography and magnetic resonance imaging. Patients underwent a percutaneous endoscopic lumbar discectomy at our hospital from January 1, 2017, to December 31, 2019. Demographic characteristics before the surgery and perioperative outcomes were retrospectively reviewed. The treatment outcome was analyzed using the numerical rating scale (NRS) score, Oswestry Disability Index (ODI) score, and modified Macnab criteria.

Results: Patients in groups A and B showed significant improvement in both the NRS and ODI scores after the surgery and maintained relatively low ODI and NRS scores during subsequent follow-ups. According to the evaluation under the modified MacNab standard, the good-excellent rate of clinical efficacy was 94% in group A and 92.6% in group B at the 3 month follow-up. In group A, one patient developed neck pain during the surgery, which was diagnosed as spinal hypertension syndrome, and the surgery was suspended until the patient's condition improved. No similar complications occurred in group B. In both the groups, no patient reported any dural leak, infection, or other related complications.

Conclusion: The use of transforaminal remolding technology can significantly improve the symptoms and dysfunction of patients with calcified and non calcified lumbar disc herniation. There are few intraoperative and postoperative complications and have little impact on vertebral stability. It can provide a reference for the treatment of special types of lumbar disc herniation.
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http://dx.doi.org/10.2147/JPR.S357033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9208632PMC
June 2022

Periodontitis may induce gut microbiota dysbiosis via salivary microbiota.

Int J Oral Sci 2022 Jun 23;14(1):32. Epub 2022 Jun 23.

Department of Periodontology, Nanjing Stomatological Hospital, Medical School of Nanjing University, No.30 Zhongyang Road, Nanjing, China.

The aim of this study was to identify whether periodontitis induces gut microbiota dysbiosis via invasion by salivary microbes. First, faecal and salivary samples were collected from periodontally healthy participants (PH group, n = 16) and patients with severe periodontitis (SP group, n = 21) and analysed by 16S ribosomal RNA sequencing. Significant differences were observed in both the faecal and salivary microbiota between the PH and SP groups. Notably, more saliva-sourced microbes were observed in the faecal samples of the SP group. Then, the remaining salivary microbes were transplanted into C57BL6/J mice (the C-PH group and the C-SP group), and it was found that the composition of the gut microbiota of the C-SP group was significantly different from that of the C-PH group, with Porphyromonadaceae and Fusobacterium being significantly enriched in the C-SP group. In the colon, the C-SP group showed significantly reduced crypt depth and zonula occludens-1 expression. The mRNA expression levels of pro-inflammatory cytokines, chemokines and tight junction proteins were significantly higher in the C-SP group. To further investigate whether salivary bacteria could persist in the intestine, the salivary microbiota was stained with carboxyfluorescein diacetate succinimidyl ester and transplanted into mice. We found that salivary microbes from both the PH group and the SP group could persist in the gut for at least 24 h. Thus, our data demonstrate that periodontitis may induce gut microbiota dysbiosis through the influx of salivary microbes.
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http://dx.doi.org/10.1038/s41368-022-00183-3DOI Listing
June 2022

Fully Inkjet-Printed Chemiresistive Sensor Array Based on Molecularly Imprinted Sol-Gel Active Materials.

ACS Sens 2022 Jun 22. Epub 2022 Jun 22.

Graduate School of Systems Life Sciences, Kyushu University, Fukuoka 819-0395, Japan.

The fabrication of chemiresistive sensors by inkjet printing is recognized as a breakthrough in gas-sensing applications. One challenge of this technology, however, is how to enhance the cross-selectivity of the sensor array. Herein, we present a ketjen black (KB) ink and molecularly imprinted sol-gel (MISG) inks to support the fabrication of a fully inkjet-printed chemiresistive sensor array, enabling the highly accurate recognition of volatile organic acids (VOAs) on the molecular level. The MISG/KB sensor array was prepared on a glossy photographic paper with a three-layer structure: a circuit layer by a commercial silver ink, a conductive layer by a KB ink, and an active selective layer by MISG inks imprinted by different templates. Hexanoic acid (HA), heptanoic acid, and octanoic acid were used as templates to prepare the MISGs and as targets to evaluate the detection and discrimination performance of the sensor array. Three resultant MISG/KB sensors exhibited high sensitivity and selectivity to VOA vapors. The limit of detection and imprinting factor were 0.018 ppm and 7.82, respectively, for HA-MISG/KB sensors to the corresponding target. With linear discriminant analysis of the gas responses, the MISG/KB sensor array can realize high discrimination to VOAs in single and binary mixtures. Furthermore, the proposed sensor array showed strong sensor robustness with excellent consistency, durability, bending, and humidity resistance. This work developed a fully inkjet-printed chemiresistive sensor array, enabling the realization of high cross-selectivity detection, achieving low-cost, scalable, and highly reproducible sensor fabrication, moving it closer to reliable, commercial, and wearable multi-analyte human body odor analysis potential.
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http://dx.doi.org/10.1021/acssensors.2c00093DOI Listing
June 2022

Adverse drug reactions of statin therapy in China from 1989 to 2019: a national database analysis.

Eur J Hosp Pharm 2022 Jun 21. Epub 2022 Jun 21.

College of Foreign Language, Putian University, Putian, People's Republic of China.

Background: The baseline incidence of the adverse events of statin therapy varies between countries. Notably, Chinese patients seem more susceptible to myopathy induced by simvastatin.

Objectives: This research studies the adverse drug reactions (ADRs) of statin therapy in China by analysing trial-based data from the Anti-hyperlipidaemic Drug Database built by the China National Medical Products Administration Information Centre.

Methods: All clinical trials involving statin therapy (including simvastatin, atorvastatin, fluvastatin, lovastatin, pravastatin and rosuvastatin) in China from 1989 to 2019 were screened. In total, 569 clinical studies with 37 828 patients were selected from 2650 clinical trials in the database.

Results: Among the reported cases with ADRs (2822/37 828; 7.460%), gastrointestinal symptoms were the most common (1491/37 828; 3.942%), followed by liver disease (486/37 828; 1.285%), muscle symptoms (444/37 828; 1.174%) and neurological symptoms (247/37 828; 0.653%). Pravastatin (231/1988; 11.620%) caused the most common gastrointestinal side effects, followed by fluvastatin (333/3094; 10.763%). The least likely to cause gastrointestinal irritation was rosuvastatin (82/1846; 4.442%).

Conclusion: In Chinese clinical trials, gastrointestinal symptoms were the most common ADR of statin use for hyperlipidaemia and other cardiovascular diseases.
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http://dx.doi.org/10.1136/ejhpharm-2022-003333DOI Listing
June 2022

Freezing solute atoms in nanograined aluminum alloys via high-density vacancies.

Nat Commun 2022 Jun 17;13(1):3495. Epub 2022 Jun 17.

State Key Laboratory for Mechanical Behavior of Materials, School of Materials Science and Engineering, Xi'an Jiaotong University, Xi'an, 710049, China.

Low-temperature decomposition of supersaturated solid solution into unfavorable intergranular precipitates is a long-standing bottleneck limiting the practical applications of nanograined aluminum alloys that are prepared by severe plastic deformation. Minimizing the vacancy concentration is generally regarded as an effective approach in suppressing the decomposition process. Here we report a counterintuitive strategy to stabilize supersaturated solid solution in nanograined Al-Cu alloys via high-density vacancies in combination with Sc microalloying. By generating a two orders of magnitude higher concentration of vacancies bonded in strong (Cu, Sc, vacancy)-rich atomic complexes, a high thermal stability is achieved in an Al-Cu-Sc alloy that precipitation is nearly suppressed up to ~230 °C. The solute-vacancy complexes also enable the nanograined Al-Cu alloys with higher strength, greater strain hardening capability and ductility. These findings provide perspectives towards the great potentials of solute-vacancy interaction and the development of nanograined alloys with high stability and well-performed mechanical properties.
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http://dx.doi.org/10.1038/s41467-022-31222-6DOI Listing
June 2022

Anesthetic management for cesarean section in parturient with an uncorrected single ventricle: A case report and literature review.

Medicine (Baltimore) 2022 Jun 17;101(24):e29421. Epub 2022 Jun 17.

Department of Anesthesiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, China.

Rationale: Patients with a single ventricle, who have not undergone surgery, reportedly have a lower survival rate. Furthermore, multiple pregnancies are rare among these females. We reported a case of anesthesia management of cesarean section in an uncorrected single-ventricular multi-pregnancy woman and review the anesthesia management of the published similar cases.

Patient Concerns: An uncorrected single ventricular pregnant woman with a cardiac function of New York Heart Association class II, who had experienced one spontaneous abortion and three vaginal deliveries, was scheduled for cesarean section at 37+6 weeks of gestation.

Diagnoses: : Echocardiography revealed a complex congenital heart disease in the mother: a single ventricle (the left ventricle is dominant), atrioventricular valve ectopic, double-inlet left ventricle, abnormal location of the great arteries, probably pulmonary stenosis, atrial septal defect, and left-to-right shunt. The fetus was in breech presentation with umbilical cord around the neck.

Interventions: Cesarean section was successfully performed under the combined spinal epidural anesthesia with careful monitoring.

Outcomes: : Both mother and newborn recovered good and were discharged from the hospital 5 days after surgery without any adverse reactions.

Lessons: Single ventricular pregnant woman with a cardiac function of New York Heart Association class I-II could tolerate pregnancy and delivery well. Both general and regional anesthesia are applicable to cesarean section in these patients. The principle of anesthesia management is to maintain the appropriate balance between systemic vascular resistance and pulmonary vascular resistance, as well as to maintain preload and cardiac output.
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http://dx.doi.org/10.1097/MD.0000000000029421DOI Listing
June 2022

Effect of Psychological Intervention-Assisted Comfort Nursing Based on PERMA Model on Stress and Psychological Changes of Patients after Breast Cancer Surgery.

Comput Math Methods Med 2022 7;2022:1853754. Epub 2022 Jun 7.

Department of Hospital Infection-Control Department, People's Hospital of Dongxihu District, Wuhan, Hubei 430040, China.

Objective: To investigate the emotional response, stress and psychological changes of patients with breast cancer after surgery for psychological intervention-assisted comfort nursing based on the PERMA model.

Methods: A total of 100 postoperative breast cancer patients admitted to our hospital from March 2019 to June 2021 were selected as prospective research objects. According to a random number table, they were divided into a control group and an observation group with 50 cases each. Among them, the control group implemented routine nursing care, and the observation group implemented psychological intervention-assisted comfort care based on the PERMA model on the basis of the control group. The differences in compliance behavior, self-care ability, emotional response, stress response changes, and pain scores of the two groups of breast cancer patients before and after nursing were compared.

Results: After nursing, the mental behavior scores, exercise scores, medication scores, and balanced diet scores of the two groups of breast cancer patients after surgery were significantly improved. The observation group's compliance behavior scores were significantly higher than those of the control group. In the two groups of breast cancer patients, postoperative anxiety, depression, fatigue, and anger of the patients were significantly improved, and the emotional response score of the observation group was significantly lower than that of the control group. The self-care skill score, self-responsibility score, health knowledge score, and self-concept score of the observation group were excellent compared with those of the control group; the difference was significant by the above statistics ( < 0.05). The HR and MAP of the control group during the operation were higher than those 1 day before the start of the operation and decreased at the end of the operation, but still higher than the level 1 day before the start of the operation; the change trend of the observation group was the same as that of the control group, but there were differences between the time points. There was no significant significance ( > 0.05). The HR and MAP of the observation group during the operation were lower than those of the control group, and the MAP at the end of the operation was lower than that of the control group. This difference was statistically significant ( < 0.05). In the control group, the values increased at the time point during the operation and decreased at the end of the operation, but still higher than the level 1 day before the operation. The difference was statistically significant ( < 0.05). The change trend of the observation group was the same as that of the control group; and the values during and at the end of the operation were all lower than those of the control group. This difference was statistically significant ( < 0.05). The pain scores of the two groups of patients at different time points were significantly improved, and the observation group was significantly less than the control group. This difference was statistically significant ( < 0.05).

Conclusion: Psychological intervention-assisted comfort nursing can effectively enhance the compliance behavior of patients after breast cancer surgery, improve the emotional response, stress response, and pain of patients, and have certain reference value for the nursing of patients after breast cancer surgery.
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http://dx.doi.org/10.1155/2022/1853754DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9197632PMC
June 2022

The Underlying Molecular Basis and Mechanisms of Venous Thrombosis in Patients with Osteomyelitis: A Data-Driven Analysis.

Genet Res (Camb) 2022 6;2022:5672384. Epub 2022 Jun 6.

Department of Orthopaedics, Fuzhou Second Hospital of Xiamen University, School of Medicine, Xiamen University, Fuzhou 350007, China.

Objective: Osteomyelitis (OM) is one of the most risky and challenging diseases. Emerging evidence indicates OM is a risk factor for increasing incidence of venous thromboembolism (VTE) development. However, the mechanisms have not been intensively investigated.

Methods: The OM-related dataset GSE30119 and VTE-related datasets GSE19151 and GSE48000 were downloaded from the Gene Expression Omnibus (GEO) database and analyzed to identify the differentially expressed genes (DEGs) (OMGs1 and VTEGs1, respectively). Functional enrichment analyses of Gene Ontology (GO) terms were performed. VTEGs2 and OMGs2 sharing the common GO biological process (GO-BP) ontology between OMGs1 and VTEGs1 were detected. The TRRUST database was used to identify the upstream transcription factors (TFs) that regulate VTEGs2 and OMGs2. The protein-protein interaction (PPI) network between VTEGs2 and OMGs2 was constructed using the Search Tool for the Retrieval of Interacting Genes (STRING) database and then visualized in Cytoscape. Topological properties of the PPI network were calculated by NetworkAnalyzer. The Molecular Complex Detection (MCODE) plugin was utilized to perform module analysis and choose the hub modules of the PPI network.

Results: A total of 587 OMGs1 and 382 VTEGs1 were identified from the related dataset, respectively. GO-BP terms of OMGs1 and shared DGEs1 were mainly enriched in the neutrophil-related immune response process, and the shared GO-BP terms of OMGs1 and VTEGs1 seemed to be focused on cell activation, immune, defense, and inflammatory response to stress or biotic stimulus. 230 VTEGs2, 333 OMGs2, and 13 shared DEGs2 were detected. 3 TF-target gene pairs (SP1-LSP1, SPI1-FCGR1A, and STAT1-FCGR1A) were identified. The PPI network contained 1611 interactions among 467 nodes. The top 10 hub proteins were TP53, IL4, MPO, ELANE, FOS, CD86, HP, SOCS3, ICAM1, and SNRPG. Several core nodes (such as MPO, ELANE, and CAMP) were essential components of the neutrophil extracellular traps (NETs) network.

Conclusion: This is the first data-mining study to explore shared signatures between OM and VTE by the integrated bioinformatic approach, which can help uncover potential biomarkers and therapeutic targets of OM-related VTE.
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http://dx.doi.org/10.1155/2022/5672384DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9192329PMC
June 2022

A clinical study of peripherally inserted central catheter-related venous thromboembolism in patients with hematological malignancies.

Sci Rep 2022 Jun 14;12(1):9871. Epub 2022 Jun 14.

Department of Hematology, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, 621000, China.

This study aimed to explore the risk factors of peripherally inserted central catheter (PICC)-related venous thromboembolism (CRT) in patients with hematological malignancies and the predictive ability of the thrombotic risk assessment models (RAMs). The clinical data of the 117 eligible patients with hematological neoplasms at Mianyang Central Hospital with PICC from May 2018 to May 2020 were analyzed in this retrospective study. Thrombosis risk scores were calculated in patients with image-confirmed PICC-related thromboembolism. CRT occurred in 19 cases. Compared to the CRT-free group, the CRT group was older and showed higher body mass index (BMI), leukocyte count level, and the prevalence of diabetes mellitus. Multivariable logistic regression analysis showed that BMI (P = 0.03) was a significant risk factor for CRT. The area under the receiver operating characteristic curve for the Caprini scale (P = 0.01) was higher than that of the modified Wells scale (P = 0.94), the revised Geneva scale (P = 0.83), Padua scale (P = 0.59), and Michigan scale (P = 0.80). The sensitivity and specificity for the Caprini scale, Padua scale, modified Wells scale, the revised Geneva scale, and Michigan risk score were 63.3%/73.7%, 100%/0.00%, 95.9%/5.3%, 31.6%/73.7%, and 1.0%/99.0%, respectively. Caprini RAM had a better predictive ability for CRT in patients with hematological malignancies. Michigan risk score may not be better than Caprini RAM in this population.
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http://dx.doi.org/10.1038/s41598-022-13916-5DOI Listing
June 2022

Uranium Decorporation by a Tailor-Made Hexadentate Ligand.

J Am Chem Soc 2022 Jun 14. Epub 2022 Jun 14.

State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), and Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou 215123, China.

The sequestration of uranium, particularly from the deposited bones, has been an incomplete task in chelation therapy for actinide decorporation. Part of the reason is that all previous decorporation ligands are not delicately designed to meet the coordination requirement of uranyl cations. Herein, guided by DFT calculation, we elaborately design a hexadentate ligand (TAM-2LI-MAM), whose preorganized planar oxo-donor configuration perfectly matches the typical coordination geometry of the uranyl cation. This leads to an ultrahigh binding affinity to uranyl supported by an desorption experiment of uranyl phosphate. Administration of this ligand by prompt intraperitoneal injection demonstrates its uranyl removal efficiencies from the kidneys and bones are up to 95.4% and 81.2%, respectively, which notably exceeds all the tested chelating agents as well as the clinical drug ZnNa-DTPA, setting a new record in uranyl decorporation efficacy.
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http://dx.doi.org/10.1021/jacs.2c00688DOI Listing
June 2022

Posttranslational modifications in diabetes: Mechanisms and functions.

Rev Endocr Metab Disord 2022 Jun 13. Epub 2022 Jun 13.

Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases, Ministry of Education, Gannan Medical University, 323 National Road, Ganzhou, 341000, Jiangxi, China.

As one of the most widespread chronic diseases, diabetes and its accompanying complications affect approximately one tenth of individuals worldwide and represent a growing cause of morbidity and mortality. Accumulating evidence has proven that the process of diabetes is complex and interactive, involving various cellular responses and signaling cascades by posttranslational modifications (PTMs). Therefore, understanding the mechanisms and functions of PTMs in regulatory networks has fundamental importance for understanding the prediction, onset, diagnosis, progression, and treatment of diabetes. In this review, we offer a holistic summary and illustration of the crosstalk between PTMs and diabetes, including both types 1 and 2. Meanwhile, we discuss the potential use of PTMs in diabetes treatment and provide a prospective direction for deeply understanding the metabolic diseases.
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http://dx.doi.org/10.1007/s11154-022-09740-xDOI Listing
June 2022

Pressure-Quenched Superconductivity in Weyl Semimetal NbP Induced by Electronic Phase Transitions under Pressure.

J Phys Chem Lett 2022 Jun 13;13(24):5514-5521. Epub 2022 Jun 13.

Center for High Pressure Science and Technology Advanced Research, Beijing 100094, People's Republic of China.

The TaAs family (NbAs, TaAs, NbP, TaP) are kinds of Weyl semimetals with lots of novel properties, thus attracting considerable attention in recent years. Here, we systematically studied the Weyl semimetal NbP up to 72 GPa through the resistivity, Raman spectra, X-ray diffraction measurements, and first-principles density functional theory (DFT) calculations. A pressure-induced semimetal-metal transition was observed at ∼36 GPa, which was further confirmed by the DFT calculations. With further compression up to 52 GPa, a superconducting state was observed. Interestingly, the increases significantly upon decompression and shows a dome-shaped trend as a function of pressure. Surprisingly, the pressure-induced superconductivity can be quenched to ambient pressure, and all transitions under pressure do not involve any structural change. Our work not only depicts a phase diagram of the NbP system under high pressure but also provides a new experimental insight for superconductivity in Weyl semimetals.
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http://dx.doi.org/10.1021/acs.jpclett.2c01266DOI Listing
June 2022

Efficacy of Platelet-Rich Plasma in the Treatment of Fractures: A Meta-Analysis.

Comput Math Methods Med 2022 2;2022:5105725. Epub 2022 Jun 2.

Department of Orthopaedics, The Second Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang 314000, China.

Background: Although numerous studies have reported the effectiveness of platelet-rich plasma (PRP) in promoting and enhancing bone healing, many orthopedic physicians remain skeptical of platelet-rich plasma in the treatment of fractures. The objective of this meta-analysis was to assess the efficacy of PRP in the treatment of fractures.

Methods: We search for research on PRP treatment of fractures in Pubmed, Embase, Medline, and Cochrane libraries. Two independent reviewers assessed included studies and met to develop a consensus on included studies. We also assessed the risk of bias using Review Manager 5.3 software.

Results: The present meta-analysis included 10 randomized controlled trials (RCT) containing 652 patients. In the fixed-effect meta-analysis of 10 RCTs, 8 RCTs found that fracture patients benefited from PRP treatment. The use of PRP reduced the time of fracture healing in 4 RCTs. Three RCTs found that PRP adjuvant therapy enhanced bone mineral density in the fracture trace and reduced the time of bone regeneration in mandibular fractures patients (standardized mean difference (SMD) = -1.99, 95%confidence interval (CI) = -2.64--1.35). And 3 RCTs found that PRP adjuvant therapy decreased the risk of revision surgery in fracture patients (SMD = 1.83, 95%CI = 1.10-3.04).

Conclusion: PRP adjuvant therapy is beneficial for the treatment of fracture patients, particularly those with mandibular fractures, and decreased the risk of revision surgery in fracture patients.
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http://dx.doi.org/10.1155/2022/5105725DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9184162PMC
June 2022

Diagnostic Value of the Blood Neutrophil-to-Lymphocyte Ratio and Monocyte-to-Lymphocyte Ratio in Tibia Fracture-Related Infection.

Dis Markers 2022 2;2022:6119583. Epub 2022 Jun 2.

Department of Orthopaedics, Fuzhou Second Hospital, The Third Clinical Medical College, Fujian Medical University, Fuzhou 350007, China.

Objective: The diagnostic value of neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), and platelet-to-lymphocyte ratio (PLR) in predicting fracture-related infection (FRI) in tibia fracture patients remains to be explored.

Methods: A retrospective controlled study was carried out with 170 tibia FRI patients and 162 control subjects. The following information was evaluated at admission: age, gender, clinical features, number of white blood cells (WBCs), neutrophils, lymphocytes, monocytes, red blood cells (RBCs), platelets, level of hemoglobin, C-reactive protein (CRP), and erythrocyte sedimentation rate (ESR), as well as NLR, MLR, and PLR.

Results: The number of lymphocytes, RBCs, and platelets in the FRI group was higher than those in the control group, while the number of neutrophils and ESR level was lower ( < 0.05). The level of NLR and MLR was significantly lower in patients with tibia FRI than in control subjects ( < 0.05). Both indicators were positively correlated with WBCs, CRP level, and ESR level ( < 0.001). The results of logistic regression analysis showed that five variables including NLR, MLR, platelets, fracture pattern (closed or open fracture), and site pattern (single or multiple site) were used to construct the FRI risk predictor. The ROC curve analysis result showed that FRI risk predictor yielded the highest AUC, with a sensitivity of 91.2% and a specificity of 90.1%, and made the distinction efficiently between tibia FRI patients and non-FRI patients.

Conclusion: NLR and MLR were decreased in tibia FRI patients compared to non-FRI patients. Both indicators had a positive correlation with WBCs, CRP level, and ESR level. FRI risk predictor constructed based on five variables including NLR and MLR had a high diagnostic value for tibia FRI.
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http://dx.doi.org/10.1155/2022/6119583DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9184170PMC
June 2022

Solar flare accelerates nearly all electrons in a large coronal volume.

Nature 2022 06 8;606(7915):674-677. Epub 2022 Jun 8.

Center for Solar-Terrestrial Research, New Jersey Institute of Technology, Newark, NJ, USA.

Solar flares, driven by prompt release of free magnetic energy in the solar corona, are known to accelerate a substantial portion (ten per cent or more) of available electrons to high energies. Hard X-rays, produced by high-energy electrons accelerated in the flare, require a high ambient density for their detection. This restricts the observed volume to denser regions that do not necessarily sample the entire volume of accelerated electrons. Here we report evolving spatially resolved distributions of thermal and non-thermal electrons in a solar flare derived from microwave observations that show the true extent of the acceleration region. These distributions show a volume filled with only (or almost only) non-thermal electrons while being depleted of the thermal plasma, implying that all electrons have experienced a prominent acceleration there. This volume is isolated from a surrounding, more typical flare plasma of mainly thermal particles with a smaller proportion of non-thermal electrons. This highly efficient acceleration happens in the same volume in which the free magnetic energy is being released.
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http://dx.doi.org/10.1038/s41586-022-04728-8DOI Listing
June 2022

Survival Analysis and Associated Factors for Pulmonary Tuberculosis Death: Evidence from the Information System of Tuberculosis Disease and Mortality Surveillance in China.

Risk Manag Healthc Policy 2022 31;15:1167-1178. Epub 2022 May 31.

Department of Non-Communicable Disease Prevention, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, Zhejiang Province, People's Republic of China.

Background: Pulmonary tuberculosis (PTB) is a severe infection, and its factors that influence survival have not been explored in some developed regions. Therefore, this study aimed to identify the factors that influence TB survival in China.

Methods: We acquired data of PTB deaths through matching two manage systems of PTB and mortality surveillance. The Kaplan-Meier method and Cox regression model were used to identify the significant factors under various survival times.

Results: A total of 283 deaths were caused by PTB, in which 53.4% occurred during the first year. In the Cox regression model, regular sputum smear test could reduce the risk of PTB death from the result of one-, three-, and five-year survival; and history of PTB treatment could decline the risk of PTB death in the first year. Additionally, age of "75-90 years" and positive result of sputum smear test significantly increased the risk of PTB death for the findings of three- and five-year survival, while age of "60-75 years" could increase the probability of PTB death for five-year survival.

Conclusion: To reduce PTB deaths, more attention should be paid to the older group especially in the first year. Regular sputum smear test could effectively reduce the mortality of PTB cases. More evidence-based interventions should be implemented to enhance the survival of patients with PTB.
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http://dx.doi.org/10.2147/RMHP.S368593DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9166951PMC
May 2022

Quercetin Inhibits Tumorigenesis of Colorectal Cancer Through Downregulation of hsa_circ_0006990.

Front Pharmacol 2022 18;13:874696. Epub 2022 May 18.

Department of Oncology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Quercetin can significantly inhibit the progression of colorectal cancer (CRC). However, its specific mechanism remains largely unclear. In this study, we aimed to explore the correlation among quercetin, tumour-associated macrophages (TAMs) and circular RNAs (circRNAs) in the progression of CRC and to present a novel strategy for the treatment of CRC. In this study, we revealed that quercetin could suppress the autophagy of M2-TAMs and induced their differentiation into M1-TAMs, by which quercetin significantly reversed the inhibition of M2-TAMS on CRC cell apoptosis and the promotion of M2-TAMS on CRC cell proliferation. Moreover, quercetin could promote the expression of downregulated hsa_circ_0006990 in CRC cells co-cultured with M2-TAMs, and the overexpression of hsa_circ_0006990 significantly reversed the anti-tumour effect of quercetin on CRC. Furthermore, we found quercetin can notably suppress the progression of CRC via mediation of the hsa_circ_0006990/miR-132-3p/MUC13 axis. In conclusion, our results suggested that quercetin inhibits the tumorigenesis of CRC inhibiting the polarisation of M2 macrophages and downregulating hsa_circ_0006990. Our study provides useful insights for those exploring new methods of treating CRC.
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http://dx.doi.org/10.3389/fphar.2022.874696DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9158466PMC
May 2022

Glutathione S-transferase (GST) genes and their function associated with pyrethroid resistance in the malaria vector Anopheles sinensis.

Pest Manag Sci 2022 Jun 5. Epub 2022 Jun 5.

Chongqing Key Laboratory of Vector Insects; Institute of Entomology and Molecular Biology, College of Life Sciences, Chongqing Normal University, Chongqing, People's Republic of China.

Background: Glutathione S-transferases (GSTs), a multifunctional protein family, are involved in insecticide resistance. However, a systematic analysis of GSTs in Anopheles sinensis, an important vector for malaria transmission, is lacking. In this study, we investigated the diversity and characteristics of GST genes, and analyzed their expression patterns and functions associated with insecticide resistance in this species.

Results: We identified 32 putative cytosolic and three putative microsomal GST genes in the An. sinensis genome. Transcriptome analysis showed that GSTs were highly expressed in larvae, and mainly expressed in the antennae, midgut and Malpighian tubules of adults. In addition, we found that GSTd2 and GSTe2 were significantly upregulated in four An. sinensis pyrethroid-resistant field populations. Furthermore, silencing of GSTd2 and GSTe2 significantly increased the susceptibility of An. sinensis to deltamethrin, and recombinant GSTd2 and GSTe2 exhibited high enzymatic activity in the metabolism of 1-chloro-2,4-dinitrobenzene and dichlorodiphenyltrichloroethane (DDT).

Conclusion: These results showed that GSTs are involved in the development of insecticide resistance in An. sinensis through transcriptional overexpression and enzymatic metabolization, facilitating our understanding of insecticide resistance in insects. © 2022 Society of Chemical Industry.
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http://dx.doi.org/10.1002/ps.7031DOI Listing
June 2022

Comparative efficacy and acceptability of drug treatments for Parkinson's disease with depression: A systematic review with network meta-analysis.

Eur J Pharmacol 2022 Jul 1;927:175070. Epub 2022 Jun 1.

Department of Anatomy, School of Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China. Electronic address:

Depressive symptom is the prevailing non-motor symptom of Parkinson's disease (PD). Drug treatments for depressed PD (dPD) can mitigate the symptoms of patients. However, the results are discordant and need further analysis. This systematic review with network meta-analysis aims to evaluate the drug treatments for dPD. We included double-blind, randomized controlled trials to compare antidepressants with placebo or other antidepressants in dPD. We performed traditional pairwise analysis and network meta-analysis concerning the efficacy, acceptability, depression score, and adverse effect. The surface under the cumulative ranking curve was to assess the ranking probabilities of the enrolled agents. We enrolled 62 studies, including 12,353 subjects, to analyze these estimates. For the traditional pairwise meta-analysis, dopamine agonist (DOP; OR = 2.20 [95% CI, 1.46 to 3.33]) and selective serotonin reuptake inhibitor (SSRI; OR = 2.30 [95% CI, 1.15 to 4.60]) were observed to improve the efficacy compared with placebo. For network meta-analysis, DOP was observed to improve the efficacy compared with placebo (OR = -0.84 [95% CI, -1.20 to -0.48]). Both direct and indirect evidence showed that several treatments, e.g., DOP, monoamine-oxidase inhibitor, serotonin-norepinephrine reuptake inhibitors, SSRI, and tricyclic antidepressants, significantly improved depressive symptoms. DOP and SSRI had good efficacy and improved symptoms considerably in dPD, but the adverse effect of these agents was needed to follow closely.
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http://dx.doi.org/10.1016/j.ejphar.2022.175070DOI Listing
July 2022

A Review of Computer Vision-Based Structural Deformation Monitoring in Field Environments.

Sensors (Basel) 2022 May 16;22(10). Epub 2022 May 16.

College of Civil Engineering, Zhejiang University of Technology, Hangzhou 310014, China.

Computer vision-based structural deformation monitoring techniques were studied in a large number of applications in the field of structural health monitoring (SHM). Numerous laboratory tests and short-term field applications contributed to the formation of the basic framework of computer vision deformation monitoring systems towards developing long-term stable monitoring in field environments. The major contribution of this paper was to analyze the influence mechanism of the measuring accuracy of computer vision deformation monitoring systems from two perspectives, the physical impact, and target tracking algorithm impact, and provide the existing solutions. Physical impact included the hardware impact and the environmental impact, while the target tracking algorithm impact included image preprocessing, measurement efficiency and accuracy. The applicability and limitations of computer vision monitoring algorithms were summarized.
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http://dx.doi.org/10.3390/s22103789DOI Listing
May 2022

The Insecticidal Efficacy and Physiological Action Mechanism of a Novel Agent GC16 against (Acari: Tetranychidae).

Insects 2022 May 5;13(5). Epub 2022 May 5.

State Key Laboratory of Conservation and Utilization of Biological Resources of Yunnan, College of Plant Protection, Yunnan Agricultural University, Kunming 650201, China.

Chemical control plays a crucial role in pest management but has to face challenges due to insect resistance. It is important to discover alternatives to traditional pesticides. The spider mite (Ehara & Gotoh) (Acari: Tetranychidae) is a major agricultural pest that causes severe damage to many crops. GC16 is a new agent that consists of a mixture of Calcium chloride (CaCl) and lecithin. To explore the acaricidal effects and mode of action of GC16 against , bioassays, cryogenic scanning electron microscopy (cryo-SEM) and transmission electron microscopy (TEM) were performed. GC16 had lethal effects on the eggs, larvae, nymphs, and adults of , caused the mites to dehydrate and inactivate, and inhibited the development of eggs. GC16 displayed contact toxicity rather than stomach toxicity through the synergistic effects of CaCl with lecithin. Cryo-SEM analysis revealed that GC16 damaged by disordering the array of the cuticle layer crest. Mitochondrial abnormalities were detected by TEM in mites treated by GC16. Overall, GC16 had the controlling efficacy on by cuticle penetration and mitochondria dysfunction and had no effects on and , indicating that GC16 is likely a new eco-friendly acaricide.
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http://dx.doi.org/10.3390/insects13050433DOI Listing
May 2022

Acoustic-based whistle detection of drain hole for wind turbine blade.

ISA Trans 2022 May 12. Epub 2022 May 12.

Institute of Magnetic Levitation and Electromagnetic Propulsion, China Aerospace Institute of Science and Technology, Beijing 100074, China.

The blade is a crucial part of large-scale wind turbine for converting wind energy into electricity. Increasing attentions have been paid to the blade health monitoring in recent years. This paper focuses on acoustic-based surface damage detection of the blade and presents a novel intelligent detection method of the whistle produced by the drain hold using the pattern recognition. In the algorithm, a developed preprocessing strategy with multiband adaptive spectral subtraction can well reduce the random wind noise from raw acoustic signal. Moreover, a correlated empirical mode decomposition method in combination with morphological filtering is proposed for extracting time-frequency ridge features of whistle event. Finally, an incremental support vector machine based on adaptive reserved set strategy is designed for recognizing the whistle event. Experimental results demonstrate that proposed method is feasible and effective in whistle detection of drain hole.
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http://dx.doi.org/10.1016/j.isatra.2022.05.010DOI Listing
May 2022

[Effect of electroacupuncture invention on activities of PGC-1α/Irisin (FNDC5)/BDNF signaling in cerebral cortex, hippocampus and muscles in focal cerebral ischemic/reperfusion injury rats].

Zhen Ci Yan Jiu 2022 May;47(5):428-34

Department of Rehabilitation Medicine, Huashan Hospital, Fudan University, Shanghai 200040.

Objective: To observe the effect of electroacupuncture(EA) on the expression of peroxisome proliferator-activated receptor gamma coactivators-1-alpha (PGC-1α), Irisin and brain-derived neurotrophic factor (BDNF) in the ischemic peripheral cortex, hippocampus and local skeletal muscle in rats with focal cerebral ischemic/reperfusion injury (CI/RI), so as to explore its underlying mechanism of improving of CI/RI.

Methods: Male SD rats were randomly divided into 3 groups: sham-operation, model and EA (11 rats in each group). The focal CI/RI model was established by middle cerebral artery occlusion (MCAO). EA (2 Hz /15 Hz, 2 to 4 mA) was applied to "Quchi" (LI11) and "Zusanli" (ST36) of the affected side for 20 min, once a day for 7 days. Zea-Longa's score and Balance Beam score were used to evaluate the neurological and motor functions. The infarcted volume of the brain was detected by using 2,3,5-triphenyltetrazolium chloride staining. The expression levels of PGC-1α, fibronectin type III domain-containing protein 5(FNDC5) and BDNF proteins in the ischemic peripheral cortex, hippocampus and local skeletal muscle were detected by Western blot.

Results: Compared with the sham-operation group, the Zea-Longa's score, Balance Beam score, percentage of cerebral infarct volume were notably increased (<0.01), while the expression levels of PGC-1α, FNDC5 and BDNF proteins in the cerebral cortex and hippocampus (not in the local muscle) were significantly down-regulated in the model group (<0.01, <0.05). In comparison with the model group, the increase of Zea-Longa's score, Balance Beam score, percentage of cerebral infarct volume, and the decrease of expression levels of PGC-1α, FNDC5 and BDNF proteins in the ischemic peripheral cortex and that of BDNF in the hippocampus were reversed in the EA group (<0.01, <0.05). No significant changes were found in the expression levels of hippocampal PGC-1α and FNDC5 proteins in the hippocampus and those of PGC-1α, FNDC5 and BDNF proteins in the local muscle after EA intervention (>0.05).

Conclusion: EA can improve neurological and motor functions and reduce cerebral infarction volume in CI/RI rats, which may be related to its functions in activating PGC-1α/Irisin(FNDC5)/BDNF pathway in the cerebral cortex.
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http://dx.doi.org/10.13702/j.1000-0607.20210495DOI Listing
May 2022

Coordinated motion of molecular motors on DNA chains with branch topology.

Authors:
Di Lu Bin Chen

Acta Mech Sin 2022 16;38(3):621225. Epub 2022 Feb 16.

Department of Engineering Mechanics, Zhejiang University, Hangzhou, 310058 China.

To understand the macroscopic mechanical behaviors of responsive DNA hydrogels integrated with DNA motors, we constructed a state map for the translocation process of a single FtsK on a single DNA chain at the molecular level and then investigated the movement of single or multiple FtsK motors on DNA chains with varied branch topologies. Our studies indicate that multiple FtsK motors can have coordinated motion, which is mainly due to the force-responsive behavior of individual FtsK motors. We further suggest the potential application of motors of FtsK, together with DNA chains of specific branch topology, to serve as strain sensors in hydrogels.
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http://dx.doi.org/10.1007/s10409-021-09045-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9109741PMC
February 2022

Flag leaf cell wall functional groups and components play a crucial role in the accumulation and translocation of Cd in rice grain via foliage application of humic acid.

Ecotoxicol Environ Saf 2022 May 19;239:113658. Epub 2022 May 19.

College of Resources and Environment, Hunan Agricultural University, Changsha 410128, China. Electronic address:

Devising a low-cost and effective strategy to reduce Cd contamination of brown rice is critical to achieve the safe production of rice grain for human consumption. Accordingly, here field experiments were conducted at two sites to evaluate the effects of applying humic acid (HA) to foliage twice, at the booting and full heading stage, on diminishing the translocation of cadmium (Cd) into rice grains. Besides measuring the Cd subcellular distribution in the flag leaf and the polysaccharide composition of the cell wall, the latter's types and concentrations of functional groups were quantitatively analyzed by potentiometric titration and fitted by a surface complexation model. The results demonstrated that applying HA to leaves not only increased the rice yield but also reduced the Cd concentration in brown rice by 35.48-39.74% when using an application rate of just 600 g/ha. The HA treatment augmented Cd fixation in flag leaves, reduced the Cd translocation to rachis and brown rice, and increased the subcellular distribution of Cd in flag leaf cell wall. Furthermore, the Cd concentration in the pectin and hemicellulose 1 of cell wall increased by 33.00% and 25.73%, respectively. Besides those effects, foliar spraying of HA induced a greater abundance of carboxyl, hydroxyl, and amino groups on the cell wall, allowing for more sites to be involved in the binding of Cd, thereby promoting the immobilization of Cd in the flag leaf, and ultimately reducing the remobilization of Cd into the grain. Thus, foliage application of HA may offer a promising and cost-effective tactic for the remediation and continued use of Cd-contaminated paddy soils. CAPSULE: Foliage application of humic acid promoted the deposition of Cd in the cell wall of rice flag leaf, thereby enhancing the immobilization of Cd and ultimately reducing the remobilization of Cd into the grain.
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http://dx.doi.org/10.1016/j.ecoenv.2022.113658DOI Listing
May 2022

Understanding the structure and cutting mechanism of shaver blades: A case study on articular cartilage.

Proc Inst Mech Eng H 2022 May 20:9544119221098508. Epub 2022 May 20.

Southern Medical University Affiliated Hospital Orthopedic Trauma, Guangzhou, China.

Mechanical shaver blades have been used in minimally invasive knee arthroscopy surgery for nearly 50 years, however, the tooth structure and cutting mechanism of shaver blades were less reported. This paper designed several shaver blades (triangular tooth/TT, circular tooth/CT and convex arc tooth/CAT), defined the cutting edges and angles of the original shaver (OS) and proposed a newly designed shaver (NDS) with a positive secondary rake angle to optimize cutting performance. The cutting process and theoretical model of the OS and NDS were analysed from 2D and 3D perspectives. A comparative experimental analysis of cutting performance, including cutting force, surface roughness, and groove geometries, was carried out to verify the influence of tooth structures and secondary rake angle. The results showed that the tooth of the OS has three different cutting edges, among which the secondary cutting edge sited at the tube section contributes to the puncturing process, and the primary cutting edge located on the outer wall of the tube participates in the oblique cutting process and finally removes the soft tissue. The cutting process of the secondary cutting edge of NDS has been changed from puncturing to oblique cutting, therefore, only the oblique cutting exists throughout the shaving process. This makes the shape and quantity of the chips of OS and NDS different, which has been verified by experiment. The cutting performance of CT was superior to that of TT and CAT, highlighting the importance of tooth roots in the cutting process. Positive secondary rake angle significantly improved the cutting performance of CAT, but not that of TT with a small profile angle (30°) and CT, which means both the puncturing and oblique cutting play important roles. Not all the positive secondary rake angle was helpful to the cutting process and 30° and 45° were suggested.
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http://dx.doi.org/10.1177/09544119221098508DOI Listing
May 2022
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