Dr. Bimbadhar Valluru, M.D. - The First Affiliated Hospital of Dali University - Attending Radiologist

Dr. Bimbadhar Valluru

M.D.

The First Affiliated Hospital of Dali University

Attending Radiologist

Dali, Yunnan | China

Main Specialties: Abdominal Radiology, Cardiothoracic Radiology, Radiology-Diagnostic, Vascular & Interventional Radiology

Additional Specialties: Diagnostic Radiology and Experimental Radiology

ORCID logohttps://orcid.org/0000-0003-3234-2155

Dr. Bimbadhar Valluru, M.D. - The First Affiliated Hospital of Dali University - Attending Radiologist

Dr. Bimbadhar Valluru

M.D.

Introduction

Primary Affiliation: The First Affiliated Hospital of Dali University - Dali, Yunnan , China

Specialties:

Additional Specialties:

Research Interests:

Publications

5Publications

144Reads

16Profile Views

3PubMed Central Citations

Analysis of CT characteristics in the diagnosis of Schistosoma japonicum associated appendicitis with clinical and pathological correlation: a diagnostic accuracy study.

Jpn J Radiol 2020 Feb 10;38(2):178-191. Epub 2019 Dec 10.

The Department of Radiology and Interventional Surgery, The First Affiliated Hospital of Dali University, No- 32, Jiashi Bo Da Dao Road, Xiaguan, Dali, 671003, Yunnan, People's Republic of China.

Purpose: To clarify unique non-contrast CT (NCCT) characteristics for early recognition of Schistosomal associated appendicitis (SAA) differentiating from Non-schistosomal associated appendicitis (NSA).

Material And Methods: Clinical and pathological data of 50 cases with SAA and 60 cases with NSA who underwent emergency appendectomy were retrospectively compared to pre-surgical NCCT features such as direct and indirect signs of acute appendicitis as well as appendicoliths, colon calcifications as diagnostic criteria. Statistical methods such as Chi-square (?), t-tests, Principal component analysis (PCA), Binary Logistic regression (LR) and Factor Analysis (FA) were utilized to observe differences and isolate recognizable CT features of SAA. Pre and post hoc diagnostic performance of all criteria was calculated as sensitivity, specificity, and the Odds Ratio (OR).

Results: Age?>?50 years, diameter?>?13 mm, pneumatosis, peri appendiceal abscess, focal wall defect, perforation; Orbital, linear and point types of appendicular wall calcifications; sigmoid colon and cecal curvilinear calcifications were observed as unique characteristics with a sensitivity of 84-95% and specificity of 91-98% in predicting SAA by OR of 6.2 times. Pre and post hoc hypothetical analysis did not show any significance for all other factors.

Conclusion: Factors such as elderly age, CT features such as larger appendicular diameter, appendicular wall calcifications along with sigmoid colon, and cecal calcifications, signs of perforation or abscess are characteristic for early recognition of SAA.

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http://dx.doi.org/10.1007/s11604-019-00905-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7002366PMC
February 2020
49 Reads
1.500 Impact Factor

Significance of radiology in the diagnosis and management of ruptured left gastric artery aneurysm associated with acute pancreatitis: Case report.

Medicine (Baltimore) 2019 Mar;98(10):e14824

Department of Radiology, The First Affiliated Hospital of Dali University, Dali, Yunnan, People's Republic of China.

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http://dx.doi.org/10.1097/MD.0000000000014824DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417524PMC
March 2019
42 Reads
5.723 Impact Factor

Effects of NF-κB and the role of inflammatory response factors on the hepatocytic injury after TAE- An Experimental Study

Imaging Med. 2018 Sep 24; 10(5):117

Imaging in Medicine

Objective: To investigate the effects of NF-κB and the role of inflammatory response factors on the normal liver tissue around the tumors in rabbit VX2 hepatocellular carcinoma models after TAE.Methods: Seventy VX2 hepatoma rabbit models were prepared and success rate was 85.7%. Computed tomography (CT) and Magnetic resonance imaging (MRI) was performed after 21 days of modelling. Sixty rabbits were randomly chosen and divided into three groups, 20 in each group: TAE group, Contrast/Angiography group, and Control group respectively. TAE group was treated with Transarterial embolization (TAE) and the Contrast group was subjected to hepatic arteriography and DSA, while the Control group served as a control group. The immune-histochemistry analysis was used to detect the expression of NF-κB in normal liver tissue around the tumors of each group. The levels of inflammatory factors like TNF-α, IL-10 of each group were detected by Enzyme-linked immunosorbent assay (ELISA) in the normal liver tissue around the tumor. Using SPSS 22.0 statistical analysis software, measurement data was analyzed using t-test, count data were compared using the χ2-test; P <0.05 was considered as statistically significant. Results: The positive expression rates of NF-κB in the TAE group, contrast group, and control group were 75% (15/20), 35% (7/20) and 20% (4/20) respectively. The concentrations of TNF-α were 11.72 ± 0.65 (ng/L), 9.60 ± 0.31 (ng/L) and 8.82 ± 0.81 (ng/L); the concentrations of IL-10 were 2.18±0.13 (ng/L), 1.67 ± 0.12 (ng/L), 1.66 ± 0.10 (ng/L) respectively. Compared with the control group and contrast groups, TAE group showed a significant increase in the expression of NF-κB, and the levels of TNF-α and IL-10 were alsoincreased. Conclusion: The hepatocytic injury, degrading function after TAE could be due to the interaction of NF-κB and inflammatory factors-TNF-α and IL-10. http://dx.doi.org/10.14303/Imaging-Medicine.1000113

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September 2018

Impact Factor 1.200

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Significance of MRI in the diagnosis and differentiation of clear cell sarcoma of tendon and aponeurosis (CCSTA): A case report.

Medicine (Baltimore) 2018 Aug;97(31):e11012

Department of Radiology, The First Affiliated Hospital of Dali University, Dali, Yunnan, China.

Rationale: Clear cell sarcoma of tendon and aponeurosis (CCSTA) or soft parts is a rare malignant melanin producing tumor entity that is derived from the neural crest cells originating from soft tissues displaying melanocytic differentiation. Diagnosis of CCSTA is difficult as it is dependent on age, size, location, necrosis, calcifications, cystic degeneration, and local to distant metastatic deposits. These tumors have very poor prognosis with a survival rate of 5-10 years because of local recurrence, early to late metastasis to lymph nodes, lungs, bones, and liver.

Patient Concerns: A 30-year-old Asian male has presented with a painful mass in the posterior aspect of the right ankle. He recalled of noticing an increase in the size of the lump after a traumatic insult 3 months ago. Physical examination revealed a mass of size 9x4 cm in the posterior ankle with no cutaneous ulcerative lesions. There is no history of any longstanding illness or malignancy.

Diagnoses: Clear cell Sarcoma of Tendon and Aponeurosis (CCSTA) or CCS of Soft parts.

Interventions: Conventional radiography demonstrated merely a soft tissue mass in the posterior compartment of the right ankle and significant calcaneal bone erosion with the sparse trabecular pattern. Plain conventional tomography showed a well-defined soft tissue heterogeneous mass with a hypoattenuating osteo-destructive focal lesion in the calcaneus. Magnetic resonance imaging (MRI) - T1 weighted imaging (T1WI) revealed an iso-intense signal relative to adjacent muscle; heterogeneous high-signal intensity on fat saturated T2 weighted imaging (T2WI). On contrast examination, lesion on T1WI, showed a heterogeneous high signal intensity, central low signal intensity with peripheral and septal enhancement. The immune-histochemistry analysis was positive for HMB-45, S-100, myoD1 and Ki67 (30%). Correlating with imaging and immune-histochemistry, a confirmatory diagnosis of CCSTA was made.

Outcomes: CCSTA is typically a slowly growing painless mass in the deep soft tissues of ear, pancreas, kidney, penis, abdomen, especially in the lower extremities- Achilles tendon and aponeurosis of the ankle or in foot of young adults. As, these tumors are highly malignant, difficult to diagnose, early recognition by imaging and surgical excision are the mainstay of management.

Lessons: Our case emphasizes the importance of recognizing radiological characteristics of CCSTA, and its differentiation from other soft tissue tumors, when presenting atypically. MRI plays a significant role in the diagnosis supported by histopathology and immune-histochemistry. So, radiologists should be familiar about this presentation that could guide other personnel for early detection of soft tissue tumors while including CCSTA into differential diagnosis for evaluation.

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http://Insights.ovid.com/crossref?an=00005792-201808030-0000
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http://dx.doi.org/10.1097/MD.0000000000011012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6081126PMC
August 2018
43 Reads
1 Citation
5.723 Impact Factor

Significance of imaging findings in the diagnosis of heterotopic spleen-an intrapancreatic accessory spleen (IPAS): Case report.

Medicine (Baltimore) 2017 Dec;96(52):e9040

Department of Radiology.

Rationale: Accessory spleen (Heterotopic/Ectopic) or splenunculus has been attributed to the failure of the fusion of splenic primordial buds-derived from dorsal mesentery (mesodermal mesenchymal in origin) during the 5th week of embryonic organogenesis or to an extreme degree of splenic lobulation with pinching off of the spleen tissue. The most common locations for accessory spleens are the hilum of the spleen followed by adjacent to the tail of the pancreas. The patients usually present with no clinical symptoms.

Patient Concerns: A 49-year-old female undergoing a routine medical examination- Abdominal Ultrasound revealed a pancreatic mass. She was admitted into the hospital for 3 days and was put under observation. There are no specific findings during the physical examination or any related abnormalities in the laboratory investigations.

Diagnosis: Heterotopic spleen-an intrapancreatic accessory spleen (IPAS).

Interventions: Noncontrast CT of the abdomen demonstrated a soft tissue mass with a clear boundary in the tail of the pancreas. On contrast examination-the arterial phase, it was markedly enhanced, homogenous congruity similar to that of spleen; on magnetic resonance imaging (MRI)-T2WI with fat suppressed sequence, it demonstrated a regular round clear edged mass in the pancreatic tail. On Diffusion Weighted Imaging (DWI), a mass with a clear boundary was observed within the parenchyma of the pancreatic tail. The mass showed a high signal on noncontrast MRI, while on contrast examination, the mass showed a strengthening signal with homogenous enhancement as that of spleen.

Outcomes: Heterotopic spleen presentation is a very rare asymptomatic clinical condition. During the routine medical examination - it presents mostly as a solitary benign round or oval mass with a clear boundary or as an ectopic focus, either in the pancreatic tail or adjacent to the pancreatic appendage, as an incidental finding. On Contrast CT, it shows as a homogeneously enhanced density- a strengthening mass lesion, in the pancreatic tail, similar to that of spleen.

Lessons: Our case emphasizes the importance of recognizing IPAS radiological characteristics and typical variations in its presentation in an asymptomatic patient that could help the personnel to differentiate it from other mass lesions. Thus, recognizing imaging findings on Plain CT, Contrast CT and MRI plays a key role to form a conclusive diagnosis of an accessory spleen, which has to be clinically associated. So, surgeons should consider IPAS as a differential for which unnecessary resection and an unintended surgical procedure can be avoided.

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http://dx.doi.org/10.1097/MD.0000000000009040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393109PMC
December 2017
10 Reads
2 Citations
5.723 Impact Factor

Top co-authors

Zhou Zhou
Zhou Zhou

Third Military Medical University

2
Bin Yang
Bin Yang

College of Pharmacy

2
Kalyan Sharma
Kalyan Sharma

The First Affiliated Hospital of Dali University

2
Ling Liu
Ling Liu

Southeast University

1
Ya-Ru Guo
Ya-Ru Guo

The Affiliated Shengjing Hospital

1
Wenshuai Duan
Wenshuai Duan

Department of Radiology

1
Ping Zhang
Ping Zhang

Centers for Disease Control and Prevention

1