Billadeau DD

Billadeau DD

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VASP Regulates NK Cell Lytic Granule Convergence.

J Immunol 2018 Nov 3;201(10):2899-2909. Epub 2018 Oct 3.

Department of Immunology, College of Medicine, Mayo Clinic, Rochester, MN 55905;

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http://dx.doi.org/10.4049/jimmunol.1800254DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317751PMC
November 2018

WASH Regulates Glucose Homeostasis by Facilitating Glut2 Receptor Recycling in Pancreatic Beta Cells.

Diabetes 2018 Nov 13. Epub 2018 Nov 13.

Division of Oncology Research and Schulze Center for Novel Therapeutics, Mayo Clinic, Rochester, MN 55905

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http://diabetes.diabetesjournals.org/lookup/doi/10.2337/db18
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http://dx.doi.org/10.2337/db18-0189DOI Listing
November 2018

Endosomal receptor trafficking: Retromer and beyond.

Traffic 2018 Aug 21;19(8):578-590. Epub 2018 May 21.

Division of Oncology Research, Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota.

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http://doi.wiley.com/10.1111/tra.12574
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http://dx.doi.org/10.1111/tra.12574DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6043395PMC
August 2018

Glycogen synthase kinase-3β ablation limits pancreatitis-induced acinar-to-ductal metaplasia.

J Pathol 2017 Sep 27;243(1):65-77. Epub 2017 Jul 27.

Division of Oncology Research and Schulze Center for Novel Therapeutics, Mayo Clinic, Rochester, MN, USA.

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http://dx.doi.org/10.1002/path.4928DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6042855PMC
September 2017

Fructose-1,6-bisphosphatase Inhibits ERK Activation and Bypasses Gemcitabine Resistance in Pancreatic Cancer by Blocking IQGAP1-MAPK Interaction.

Cancer Res 2017 08 18;77(16):4328-4341. Epub 2017 Jul 18.

Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, Minnesota.

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http://dx.doi.org/10.1158/0008-5472.CAN-16-3143DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5581962PMC
August 2017

Cellular functions of WASP family proteins at a glance.

J Cell Sci 2017 Jul 23;130(14):2235-2241. Epub 2017 Jun 23.

Division of Oncology Research, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA

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http://dx.doi.org/10.1242/jcs.199570DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5536917PMC
July 2017

GSK-3 inhibition overcomes chemoresistance in human breast cancer.

Cancer Lett 2016 10 14;380(2):384-92. Epub 2016 Jul 14.

Center for Developmental Therapeutics, Robert H. Lurie Comprehensive Cancer Center of Northwestern University, 2170 Campus Drive, Evanston, IL 60208, USA; Chemistry of Life Processes Institute, Northwestern University, 2170 Campus Drive, Evanston, IL, 60208, USA; Northwestern Medicine Developmental Therapeutics Institute, Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Olson Pavilion, 233 East Superior Street, Chicago, IL 60611, USA; Department of Pharmacology, Feinberg School of Medicine, Northwestern University, Searle Building 8-510, 320 East Superior Street, Chicago, IL 60611, USA. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2016.07.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5786372PMC
October 2016

Monitoring receptor trafficking following retromer and WASH deregulation.

Methods Cell Biol 2015 11;130:199-213. Epub 2015 Jun 11.

Department of Biochemistry and Molecular Biology, Division of Oncology Research, Mayo Clinic, Rochester, MN, USA.

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http://dx.doi.org/10.1016/bs.mcb.2015.03.018DOI Listing
June 2016

SIRT1-Activating Compounds (STAC) Negatively Regulate Pancreatic Cancer Cell Growth and Viability Through a SIRT1 Lysosomal-Dependent Pathway.

Clin Cancer Res 2016 05 11;22(10):2496-507. Epub 2015 Dec 11.

Laboratory of Signal Transduction, Kogod Center on Aging, Mayo Clinic Cancer Center, Rochester, Minnesota. Department of Anesthesiology, Mayo Clinic College of Medicine, Rochester, Minnesota.

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http://dx.doi.org/10.1158/1078-0432.CCR-15-1760DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4867252PMC
May 2016

NFATc4 Regulates Sox9 Gene Expression in Acinar Cell Plasticity and Pancreatic Cancer Initiation.

Stem Cells Int 2016 30;2016:5272498. Epub 2015 Nov 30.

Department of Gastroenterology and Gastrointestinal Oncology, University Medical Center Göttingen, Robert-Koch Street 40, 37075 Göttingen, Germany ; Schulze Center for Novel Therapeutics, Division of Oncology Research, Mayo Clinic, 200 1st Street SW No. W4, Rochester, MN 55905, USA.

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http://dx.doi.org/10.1155/2016/5272498DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4677249PMC
December 2015

Endosomal sorting of Notch receptors through COMMD9-dependent pathways modulates Notch signaling.

J Cell Biol 2015 Nov;211(3):605-17

Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390 Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390

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http://dx.doi.org/10.1083/jcb.201505108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4639872PMC
November 2015

SNX17 affects T cell activation by regulating TCR and integrin recycling.

J Immunol 2015 May 30;194(9):4555-66. Epub 2015 Mar 30.

Department of Immunology, Mayo Clinic College of Medicine, Rochester, MN 55905;Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, Rochester, MN 55905; andDivision of Oncology Research, Schulze Center for Novel Therapeutics, Mayo Clinic College of Medicine, Rochester, MN 55905

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http://dx.doi.org/10.4049/jimmunol.1402734DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4402276PMC
May 2015

HkRP3 is a microtubule-binding protein regulating lytic granule clustering and NK cell killing.

J Immunol 2015 Apr 11;194(8):3984-96. Epub 2015 Mar 11.

Department of Immunology, Mayo Graduate School, College of Medicine, Mayo Clinic, Rochester, MN 55905; Division of Oncology Research, Schulze Center for Novel Therapeutics, College of Medicine, Mayo Clinic, Rochester, MN 55905

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http://dx.doi.org/10.4049/jimmunol.1402897DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4390494PMC
April 2015

Neuronal and immune synapses on the move at traffic.

Traffic 2015 Mar;16(3):227-8

Department of Cell Biology, Emory University, Atlanta, GA, 30322, USA.

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http://dx.doi.org/10.1111/tra.12251DOI Listing
March 2015

Dendritic cells utilize the evolutionarily conserved WASH and retromer complexes to promote MHCII recycling and helper T cell priming.

PLoS One 2014 2;9(6):e98606. Epub 2014 Jun 2.

Department of Pathology and Immunology, Division of Immunobiology, Washington University School of Medicine, St. Louis, Missouri, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0098606PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4041763PMC
January 2015

Vasodilator-stimulated phosphoprotein promotes activation of hepatic stellate cells by regulating Rab11-dependent plasma membrane targeting of transforming growth factor beta receptors.

Hepatology 2015 Jan 19;61(1):361-74. Epub 2014 Sep 19.

GI Research Unit and Cancer Cell Biology Program, Mayo Clinic, Rochester, MN; Department of Hepatobillary Surgery, the 1st Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.

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http://dx.doi.org/10.1002/hep.27251DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4262723PMC
January 2015

Nuclear FAM21 participates in NF-κB-dependent gene regulation in pancreatic cancer cells.

J Cell Sci 2015 Jan 27;128(2):373-84. Epub 2014 Nov 27.

Division of Oncology Research and Schulze Center for Novel Therapeutics, Mayo Clinic College of Medicine, Rochester, MN 55905, USA Department of Immunology, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA

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http://dx.doi.org/10.1242/jcs.161513DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4294779PMC
January 2015

Coactosin-like 1 antagonizes cofilin to promote lamellipodial protrusion at the immune synapse.

PLoS One 2014 13;9(1):e85090. Epub 2014 Jan 13.

Department of Biochemistry and Molecular Biology, College of Medicine, Mayo Clinic, Rochester, Minnesota, United States of America ; Department of Immunology, College of Medicine, Mayo Clinic, Rochester, Minnesota, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0085090PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3890291PMC
September 2014

Retromer binding to FAM21 and the WASH complex is perturbed by the Parkinson disease-linked VPS35(D620N) mutation.

Curr Biol 2014 Jul 3;24(14):1670-1676. Epub 2014 Jul 3.

The Henry Wellcome Integrated Signaling Laboratories, School of Biochemistry, Medical Sciences Building, University of Bristol, Bristol BS8 1TD, UK. Electronic address:

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http://dx.doi.org/10.1016/j.cub.2014.06.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4110399PMC
July 2014

Retromer Binding to FAM21 and the WASH Complex Is Perturbed by the Parkinson Disease-Linked VPS35(D620N) Mutation.

Curr Biol 2014 Jul 21;24(14):1678. Epub 2014 Jul 21.

The Henry Wellcome Integrated Signaling Laboratories, School of Biochemistry, Medical Sciences Building, University of Bristol, Bristol BS8 1TD, UK. Electronic address:

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http://dx.doi.org/10.1016/j.cub.2014.07.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5628949PMC
July 2014

Human immunodeficiency syndromes affecting human natural killer cell cytolytic activity.

Front Immunol 2014 21;5. Epub 2014 Jan 21.

Department of Immunology, College of Medicine, Mayo Clinic , Rochester, MN , USA ; Division of Oncology Research and Schulze Center for Novel Therapeutics, College of Medicine, Mayo Clinic , Rochester, MN , USA.

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http://dx.doi.org/10.3389/fimmu.2014.00002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3896857PMC
June 2014

Inflammation-induced NFATc1-STAT3 transcription complex promotes pancreatic cancer initiation by KrasG12D.

Cancer Discov 2014 Jun 2;4(6):688-701. Epub 2014 Apr 2.

Authors' Affiliations:Signaling and Transcription Laboratory, Department of Gastroenterology, Philipps University, Marburg; Department of Gastroenterology and Gastrointestinal Oncology, University Medical Center Göttingen, Göttingen; II. Medizinische Klinik, Klinikum rechts der Isar, Technische Universität; Institute of Pathology, Helmholtz Zentrum, Munich; Theodor Boveri Institute, University of Würzburg, Würzburg; Institute for Genetics, Justus-Liebig-University, Giessen, Germany; Schulze Center for Novel Therapeutics, Division of Oncology Research; Divisions of Anatomic Pathology and Biostatistics, College of Medicine; Laboratory of Epigenetics and Chromatin Dynamics, Department of Medicine, Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota; Barrow Brain Tumor Research Center, St. Joseph's Hospital and Medical Center, Phoenix, Arizona; and Cold Spring Harbor Laboratory, Cold Spring Harbor, New York

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http://dx.doi.org/10.1158/2159-8290.CD-13-0593DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4069603PMC
June 2014

Embryonic stem cell factors and pancreatic cancer.

World J Gastroenterol 2014 Mar;20(9):2247-54

Marta Herreros-Villanueva, Daniel D Billadeau, Jin-San Zhang, Division of Oncology Research, Schulze Center for Novel Therapeutics, Mayo Clinic College of Medicine, Rochester, MN 55905, United States.

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http://dx.doi.org/10.3748/wjg.v20.i9.2247DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3942830PMC
March 2014

Inhibition of GSK-3 induces differentiation and impaired glucose metabolism in renal cancer.

Mol Cancer Ther 2014 Feb 10;13(2):285-96. Epub 2013 Dec 10.

Corresponding Author: Debabrata Mukhopadhyay, Mayo Clinic College of Medicine, 200 First Street SW, Guggenheim 1321C, Rochester, MN 55905.

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http://dx.doi.org/10.1158/1535-7163.MCT-13-0681DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3956125PMC
February 2014

Vav1 as a central regulator of invadopodia assembly.

Curr Biol 2014 Jan 12;24(1):86-93. Epub 2013 Dec 12.

Center for Basic Research in Digestive Diseases, Mayo Clinic, Rochester, MN 55905, USA; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN 55905, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cub.2013.11.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3917499PMC
January 2014

Retromer-mediated endosomal protein sorting: all WASHed up!

Trends Cell Biol 2013 Nov 28;23(11):522-8. Epub 2013 May 28.

Cambridge Institute for Medical Research, Wellcome Trust/MRC Building, Addenbrooke's Hospital, Cambridge CB2 0XY, UK. Electronic address:

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http://dx.doi.org/10.1016/j.tcb.2013.04.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3924425PMC
November 2013

Response to letter by Insall.

Trends Cell Biol 2013 Nov 26;23(11):520-1. Epub 2013 Aug 26.

Cambridge Institute for Medical Research, Wellcome Trust/MRC Building, Addenbrookes Hospital, Cambridge, CB2 0XY, UK. Electronic address:

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http://dx.doi.org/10.1016/j.tcb.2013.07.012DOI Listing
November 2013

Epigenetic regulation of autophagy by the methyltransferase G9a.

Mol Cell Biol 2013 Oct 5;33(20):3983-93. Epub 2013 Aug 5.

Department of Immunology and Division of Oncology Research, Schulze Center for Novel Therapeutics, College of Medicine, Mayo Clinic, Rochester, Minnesota, USA.

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http://dx.doi.org/10.1128/MCB.00813-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3811684PMC
October 2013

SOX2 promotes dedifferentiation and imparts stem cell-like features to pancreatic cancer cells.

Oncogenesis 2013 Aug 5;2:e61. Epub 2013 Aug 5.

1] Division of Oncology Research, Schulze Center for Novel Therapeutics, College of Medicine, Mayo Clinic, Rochester, MN, USA [2] Department of Gastroenterology, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Hospital Donostia/Instituto Biodonostia, Universidad del País Vasco UPV/EHU, San Sebastián, Spain.

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http://dx.doi.org/10.1038/oncsis.2013.23DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3759123PMC
August 2013

IQGAP1 suppresses TβRII-mediated myofibroblastic activation and metastatic growth in liver.

J Clin Invest 2013 Mar 1;123(3):1138-56. Epub 2013 Feb 1.

GI Research Unit and Cancer Cell Biology Program, Mayo Clinic, Rochester, Minnesota 55905, USA.

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http://dx.doi.org/10.1172/JCI63836DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3582119PMC
March 2013

Trafficking defects in WASH-knockout fibroblasts originate from collapsed endosomal and lysosomal networks.

Mol Biol Cell 2012 Aug 20;23(16):3215-28. Epub 2012 Jun 20.

Department of Immunology, Division of Oncology Research, Mayo Clinic, Rochester, MN 55905, USA.

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http://dx.doi.org/10.1091/mbc.E12-02-0101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3418315PMC
August 2012

Rab GTPase regulation of retromer-mediated cargo export during endosome maturation.

Mol Biol Cell 2012 Jul 16;23(13):2505-15. Epub 2012 May 16.

Department of Cell and Developmental Biology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1091/mbc.E11-11-0915DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3386214PMC
July 2012

Multiple repeat elements within the FAM21 tail link the WASH actin regulatory complex to the retromer.

Mol Biol Cell 2012 Jun 18;23(12):2352-61. Epub 2012 Apr 18.

Department of Biochemistry, UT Southwestern Medical Center, Dallas, TX 75390, USA.

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http://dx.doi.org/10.1091/mbc.E11-12-1059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3374753PMC
June 2012

The cytoskeletal adaptor protein IQGAP1 regulates TCR-mediated signaling and filamentous actin dynamics.

J Immunol 2012 Jun 9;188(12):6135-44. Epub 2012 May 9.

Department of Immunology, Schulze Center for Novel Therapeutics, College of Medicine, Mayo Clinic, Rochester, MN 55901, USA.

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http://dx.doi.org/10.4049/jimmunol.1103487DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3370139PMC
June 2012

Restricted heterochromatin formation links NFATc2 repressor activity with growth promotion in pancreatic cancer.

Gastroenterology 2012 Feb 10;142(2):388-98.e1-7. Epub 2011 Nov 10.

Signaling and Transcription Laboratory, Department of Gastroenterology, Philipps-University of Marburg, Marburg, Germany.

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http://dx.doi.org/10.1053/j.gastro.2011.11.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3626431PMC
February 2012

High cell surface death receptor expression determines type I versus type II signaling.

J Biol Chem 2011 Oct 24;286(41):35823-33. Epub 2011 Aug 24.

Division of Oncology Research, Department of Oncology, Mayo Clinic, Rochester, Minnesota 55905, USA.

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http://dx.doi.org/10.1074/jbc.M111.240432DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3195573PMC
October 2011

Dynamic remodeling of the actin cytoskeleton by FMNL1γ is required for structural maintenance of the Golgi complex.

J Cell Sci 2011 Sep 24;124(Pt 18):3118-26. Epub 2011 Aug 24.

Department of Biochemistry and Molecular Biology, Schulze Center for Novel Therapeutics, Mayo Clinic, Rochester, MN 55901, USA.

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http://dx.doi.org/10.1242/jcs.083725DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3172187PMC
September 2011

Mutant K-Ras increases GSK-3β gene expression via an ETS-p300 transcriptional complex in pancreatic cancer.

Oncogene 2011 Aug 28;30(34):3705-15. Epub 2011 Mar 28.

Department of Immunology and Division of Oncology Research, Schulze Center for Novel Therapeutics, College of Medicine, Mayo Clinic, Rochester, MN, USA.

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http://dx.doi.org/10.1038/onc.2011.90DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3162070PMC
August 2011

Protein kinase G signaling disrupts Rac1-dependent focal adhesion assembly in liver specific pericytes.

Am J Physiol Cell Physiol 2011 Jul 30;301(1):C66-74. Epub 2011 Mar 30.

GI Research Unit and Cancer Cell Biology Program, Mayo Clinic, Rochester, Minnesota 55905, USA.

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http://dx.doi.org/10.1152/ajpcell.00038.2011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3129819PMC
July 2011

GRB2 couples RhoU to epidermal growth factor receptor signaling and cell migration.

Mol Biol Cell 2011 Jun 20;22(12):2119-30. Epub 2011 Apr 20.

Division of Oncology Research and Schulze Center for Novel Therapeutics.

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http://dx.doi.org/10.1091/mbc.E10-12-0969DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3113775PMC
June 2011

2B4 utilizes ITAM-containing receptor complexes to initiate intracellular signaling and cytolysis.

Mol Immunol 2011 May 25;48(9-10):1149-59. Epub 2011 Mar 25.

Department of Immunology, College of Medicine, Mayo Clinic, Rochester, MN 55905, United States.

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http://dx.doi.org/10.1016/j.molimm.2011.02.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3342820PMC
May 2011

Hematopoietic lineage cell-specific protein 1 functions in concert with the Wiskott-Aldrich syndrome protein to promote podosome array organization and chemotaxis in dendritic cells.

J Immunol 2011 Apr 11;186(8):4805-18. Epub 2011 Mar 11.

Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia and University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.4049/jimmunol.1003102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3467106PMC
April 2011

Structure and control of the actin regulatory WAVE complex.

Nature 2010 Nov;468(7323):533-8

Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA.

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http://dx.doi.org/10.1038/nature09623DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3085272PMC
November 2010

T cell activation at the immunological synapse: vesicles emerge for LATer signaling.

Sci Signal 2010 May 11;3(121):pe16. Epub 2010 May 11.

Department of Immunology, Division of Oncology Research, and Schulze Center for Novel Therapeutics, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA.

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http://dx.doi.org/10.1126/scisignal.3121pe16DOI Listing
May 2010

Synthesis and biological evaluation of triazol-4-ylphenyl-bearing histone deacetylase inhibitors as anticancer agents.

J Med Chem 2010 Feb;53(3):1347-56

Drug Discovery Program, Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, 833 South Wood Street, Chicago, Illinois 60612, USA.

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http://dx.doi.org/10.1021/jm901667kDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2919064PMC
February 2010

Structural and energetic mechanisms of cooperative autoinhibition and activation of Vav1.

Cell 2010 Jan;140(2):246-56

Department of Biochemistry, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-8816, USA.

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http://dx.doi.org/10.1016/j.cell.2009.12.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2825156PMC
January 2010

Hematopoietic lineage cell-specific protein 1 is recruited to the immunological synapse by IL-2-inducible T cell kinase and regulates phospholipase Cgamma1 Microcluster dynamics during T cell spreading.

J Immunol 2009 Dec 16;183(11):7352-61. Epub 2009 Nov 16.

Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia and University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.4049/jimmunol.0900973DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3715746PMC
December 2009

A FAM21-containing WASH complex regulates retromer-dependent sorting.

Dev Cell 2009 Nov;17(5):699-711

Department of Immunology, Division of Oncology Research and Schulze Center for Novel Therapeutics, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA.

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http://dx.doi.org/10.1016/j.devcel.2009.09.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2803077PMC
November 2009

Isoxazole moiety in the linker region of HDAC inhibitors adjacent to the Zn-chelating group: effects on HDAC biology and antiproliferative activity.

Bioorg Med Chem Lett 2009 Jun 20;19(11):3023-6. Epub 2009 Apr 20.

Department of Medicinal Chemistry & Pharmacognosy, University of Illinois at Chicago, Chicago, IL 60612, USA.

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http://dx.doi.org/10.1016/j.bmcl.2009.04.058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2705901PMC
June 2009

Inhibition of glycogen synthase kinase-3.

Methods Mol Biol 2008 ;468:67-75

Division of Oncology Research, Mayo Clinic College of Medicine, Rochester, MN, USA.

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http://dx.doi.org/10.1007/978-1-59745-249-6_5DOI Listing
January 2009

Dynamin 2 regulates granule exocytosis during NK cell-mediated cytotoxicity.

J Immunol 2008 Nov;181(10):6995-7001

Department of Immunology, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2692694PMC
November 2008

Characterization of the CXCR4 signaling in pancreatic cancer cells.

Int J Gastrointest Cancer 2006 ;37(4):110-9

Oncology Research Department, Mayo Clinic College of Medicine, Rochester, MN 55905, USA.

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http://dx.doi.org/10.1007/s12029-007-0011-7DOI Listing
October 2008

T cell activation and the cytoskeleton: you can't have one without the other.

Adv Immunol 2008 ;97:1-64

Department of Immunology and Oncology Research, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA.

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http://dx.doi.org/10.1016/S0065-2776(08)00001-1DOI Listing
August 2008

Use of the nitrile oxide cycloaddition (NOC) reaction for molecular probe generation: a new class of enzyme selective histone deacetylase inhibitors (HDACIs) showing picomolar activity at HDAC6.

J Med Chem 2008 Aug 22;51(15):4370-3. Epub 2008 Jul 22.

Department of Medicinal Chemistry & Pharmacognosy, Drug Discovery Program, University of Illinois at Chicago, 833 South Wood Street, Chicago, Illinois 60612, USA.

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http://dx.doi.org/10.1021/jm8002894DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3913184PMC
August 2008

PTEN gives neutrophils direction.

Nat Immunol 2008 Jul;9(7):716-8

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http://dx.doi.org/10.1038/ni0708-716DOI Listing
July 2008

A series of potent and selective, triazolylphenyl-based histone deacetylases inhibitors with activity against pancreatic cancer cells and Plasmodium falciparum.

J Med Chem 2008 Jun;51(12):3437-48

Drug Discovery Program, Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, 833 South Wood Street, Chicago, IL 60612, USA.

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http://pubs.acs.org/doi/abs/10.1021/jm701606b
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http://dx.doi.org/10.1021/jm701606bDOI Listing
June 2008

Activation of Rac1 and the exchange factor Vav3 are involved in NPM-ALK signaling in anaplastic large cell lymphomas.

Oncogene 2008 Apr 12;27(19):2728-36. Epub 2007 Nov 12.

INSERM, U563, Centre de Physiopathologie de Toulouse Purpan, Toulouse, France.

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http://dx.doi.org/10.1038/sj.onc.1210921DOI Listing
April 2008

Acridine-based agents with topoisomerase II activity inhibit pancreatic cancer cell proliferation and induce apoptosis.

J Med Chem 2008 Jan 29;51(2):179-82. Epub 2007 Dec 29.

Department of Medicinal Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, USA.

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http://dx.doi.org/10.1021/jm701228eDOI Listing
January 2008

Primers on molecular pathways. The glycogen synthase kinase-3beta.

Pancreatology 2007 1;7(5-6):398-402. Epub 2007 Oct 1.

Department of Immunology and Oncology Research, Mayo Clinic College of Medicine, Rochester, MN 55905, USA.

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http://dx.doi.org/10.1159/000108955DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2826871PMC
November 2007

Cutting edge: Rac GTPases sensitize activated T cells to die via Fas.

J Immunol 2007 Nov;179(10):6384-8

Immunoregulation Unit, Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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November 2007

WAVE2 regulates high-affinity integrin binding by recruiting vinculin and talin to the immunological synapse.

Mol Cell Biol 2007 Sep 25;27(17):5986-6000. Epub 2007 Jun 25.

Department of Immunology and Division of Oncology Research, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA.

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http://dx.doi.org/10.1128/MCB.00136-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1952166PMC
September 2007

TCR/CD28-stimulated actin dynamics are required for NFAT1-mediated transcription of c-rel leading to CD28 response element activation.

J Immunol 2007 Jul;179(2):1104-12

Department of Immunology, Mayo Clinic College of Medicine, MN 55905, USA.

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July 2007

Asef2 functions as a Cdc42 exchange factor and is stimulated by the release of an autoinhibitory module from a concealed C-terminal activation element.

Mol Cell Biol 2007 Feb 4;27(4):1380-93. Epub 2006 Dec 4.

Division of Oncology Research, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.

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http://dx.doi.org/10.1128/MCB.01608-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1800726PMC
February 2007

Regulation of T-cell activation by the cytoskeleton.

Nat Rev Immunol 2007 Feb;7(2):131-43

Department of Immunology, Mayo Clinic College of Medicine, 200 First Street South West, Rochester, Minnesota 55905, USA.

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http://dx.doi.org/10.1038/nri2021DOI Listing
February 2007