Publications by authors named "Biao Yang"

185 Publications

Experimental observation of non-Abelian topological charges and edge states.

Nature 2021 Jun 9;594(7862):195-200. Epub 2021 Jun 9.

Department of Physics and Institute for Advanced Study, The Hong Kong University of Science and Technology, Hong Kong, China.

In the last few decades, topological phase has emerged as a new classification of matter states beyond the Ginzburg-Landau symmetry-breaking paradigm. The underlying global invariant is usually well characterized by integers, such as Chern numbers or winding numbers-the Abelian charges. Very recently, researchers proposed the notion of non-Abelian topological charges, which possess non-commutative and fruitful braiding structures with multiple (more than one) bandgaps tangled together. Here we experimentally observe the non-Abelian topological charges in a time-reversal and inversion-symmetric transmission line network. The quaternion-valued non-Abelian topological charges are clearly mapped onto an eigenstate-frame sphere. Moreover, we find a non-Abelian quotient relation that provides a global perspective on the distribution of edge/domain-wall states. Our work opens the door towards characterization and manipulation of non-Abelian topological charges, which may lead to interesting observables such as trajectory-dependent Dirac/Weyl node collisions in two-dimensional systems, admissible nodal line configurations in three dimensions, and may provide insight into certain strongly correlated phases of twisted bilayer graphene.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41586-021-03521-3DOI Listing
June 2021

A Novel Graph-Based Trajectory Predictor With Pseudo-Oracle.

IEEE Trans Neural Netw Learn Syst 2021 Jun 4;PP. Epub 2021 Jun 4.

Pedestrian trajectory prediction in dynamic scenes remains a challenging and critical problem in numerous applications, such as self-driving cars and socially aware robots. Challenges concentrate on capturing pedestrians' motion patterns and social interactions, as well as handling the future uncertainties. Recent studies focus on modeling pedestrians' motion patterns with recurrent neural networks, capturing social interactions with pooling- or graph-based methods, and handling future uncertainties by using the random Gaussian noise as the latent variable. However, they do not integrate specific obstacle avoidance experiences (OAEs) that may improve prediction performance. For example, pedestrians' future trajectories are always influenced by others in front. Here, we propose the Graph-based Trajectory Predictor with Pseudo-Oracle (GTPPO), an encoder-decoder-based method conditioned on pedestrians' future behaviors. Pedestrians' motion patterns are encoded with a long short-term memory unit, which introduces temporal attention to highlight specific time steps. Their interactions are captured by a graph-based attention mechanism, which draws OAE into the data-driven learning process of graph attention. Future uncertainties are handled by generating multimodal outputs with an informative latent variable. Such a variable is generated by a novel pseudo-oracle predictor, which minimizes the knowledge gap between historical and ground-truth trajectories. Finally, the GTPPO is evaluated on ETH, UCY, and Stanford Drone datasets, and the results demonstrate state-of-the-art performance. Besides, the qualitative evaluations show successful cases of handling sudden motion changes in the future. Such findings indicate that GTPPO can peek into the future.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1109/TNNLS.2021.3084143DOI Listing
June 2021

Photoluminescence enhancement by controllable aggregation and polymerization of octanuclear gold clusters.

Chem Commun (Camb) 2021 Jun;57(47):5770-5773

The Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084, China.

Aggregation-induced luminescence behaviors of polynuclear metal clusters are intriguing but still mysterious to date. Herein, we synthesize a series of Au8 clusters with different peripheral ligands to investigate their different supramolecular assembly and distinguishable aggregation-induced luminescent behaviors in solution upon the variation of concentration and solvent polarity. Complex 1a is surrounded by two tetraphenyl ethylene (TPE) moieties, whose dense stacking engenders strong aggregation in solution. Furthermore, the incorporation of the TPE-decorated gold clusters into a polymer backbone promotes molecular restriction within a constrained polymer micelle and thus facilitates efficient emission enhancement of gold clusters. In contrast, the other two gold clusters with small ethynylbenzene and chloride as peripheral ligands exhibit low emission efficiency. The contrastive study showcases how the peripheral ligand arrangements influence assemblies of metal clusters and potentiates such effects in the rational design of cluster-based luminescent materials.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1039/d1cc01162fDOI Listing
June 2021

Effects of reductive inorganics and NOM on the formation of chlorite in the chlorine dioxide disinfection of drinking water.

J Environ Sci (China) 2021 Jun 22;104:225-232. Epub 2020 Dec 22.

Collaborative Innovation Center of Atmospheric Environment and Equipment Technology, School of Environmental Science & Engineering, Nanjing University of Information Science & Technology, Nanjing 210044, China.

Chlorine dioxide (ClO) disinfection usually does not produce halogenated disinfection by-products, but the formation of the inorganic by-product chlorite (ClO) is a serious consideration. In this study, the ClO formation rule in the ClO disinfection of drinking water was investigated in the presence of three representative reductive inorganics and four natural organic matters (NOMs), respectively. Fe and S mainly reduced ClO to ClO at low concentrations. When ClO was consumed, the ClO would be further reduced by Fe and S, leading to the decrease of ClO. The reaction efficiency of Mn with ClO was lower than that of Fe and S. It might be the case that MnO generated by the reaction between Mn and ClO had adsorption and catalytic oxidation on Mn. However, Mn would not reduce ClO. Among the four NOMs, humic acid and fulvic acid reacted with ClO actively, followed by bovine serum albumin, while sodium alginate had almost no reaction with ClO. The maximum ClO yields of reductive inorganics (70%) was higher than that of NOM (around 60%). The lower the concentration of reductive substances, the more ClO could be produced by per unit concentration of reductive substances. The results of the actual water samples showed that both reductive inorganics and NOM played an important role in the formation of ClO in disinfection.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jes.2020.11.033DOI Listing
June 2021

Antimony tin oxide/lead selenide composite as efficient counter electrode material for quantum dot-sensitized solar cells.

J Colloid Interface Sci 2021 Sep 17;598:492-499. Epub 2021 Apr 17.

Key Laboratory of Macromolecular Science of Shaanxi Province, School of Materials Science and Engineering, Shaanxi Normal University, Xi'an 710062, China. Electronic address:

Antimony tin oxide (ATO)/lead selenide (PbSe) composite was rationally designed and fabricated on fluorine doped tin oxide glass (FTO) for using as counter electrode (CE) of quantum dot sensitized solar cells (QDSSCs). The electrocatalytic activity of the CE is deeply investigated in the polysulfide electrolyte by employing the Tafel, electrochemical impedance spectroscopy (EIS) and cyclic voltammetry (CV) of the symmetrical cells. The results confirm that the ATO/PbSe CE has better electrocatalytic activity and stability than that of PbSe CE obtained by pulse voltage electrodeposition (PVD). The enhanced electrocatalytic performance of ATO/PbSe CE can be attributed to its high specific surface area, excellent permeability, conductivity and interface connectivity, which provide more electrocatalytic active sites for the reduction of polysulfide species, as well as fast channels for ions diffusion and electron transport. As a result, the CdS QDSSCs and CdS/CdSe co-sensitized QDSSCs assembled by the ATO/PbSe CE exhibits better power conversion efficiency (η) of 1.72% and 5.59%, respectively than that of PbSe CE obtained by PVD. Furthermore, photovoltaic property of the ATO/PbSe CE in CdS/CdSe co-sensitized QDSSCs keeps stable for over 200 min. This present work provides a simple and effective strategy for the construction of high-performance CE materials of QDSSCs.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jcis.2021.04.073DOI Listing
September 2021

Identification of Expression Patterns and Potential Prognostic Significance of mC-Related Regulators in Head and Neck Squamous Cell Carcinoma.

Front Oncol 2021 12;11:592107. Epub 2021 Apr 12.

Department of Oral Pathology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

5-Methylcytosine (mC) methylation is a major epigenetic technique of RNA modification and is dynamically mediated by mC "writers," "erasers," and "readers." mC RNA modification and its regulators are implicated in the onset and development of many tumors, but their roles in head and neck squamous cell carcinoma (HNSCC) have not yet been completely elucidated. In this study, we examined expression patterns of core mC regulators in the publicly available HNSCC cohort bioinformatic methods. The differentially expressed mC regulators could divide the HNSCC cohort into four subgroups with distinct prognostic characteristics. Furthermore, a three-gene expression signature model, comprised of NSUN5, DNMT1, and DNMT3A, was established to identify individuals with a high or low risk of HNSCC. To explore the underlying mechanism in the prognosis of HNSCC, screening of differentially expressed genes, followed by the analysis of functional and pathway enrichment, from individuals with high- or low-risk HNSCC was performed. The results revealed a critical role for mC RNA modification in two aspects of HNSCC: (1) dynamic mC modification contributes to the regulation of HNSCC progression and (2) expression patterns of NSUN5, DNMT1, and DNMT3A help to predict the prognosis of HNSCC.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3389/fonc.2021.592107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8072008PMC
April 2021

Atomistic investigation of surface characteristics and electronic features at high-purity FeSi(110) presenting interfacial metallicity.

Proc Natl Acad Sci U S A 2021 Apr;118(17)

Physics Department, Technical University of Munich, Garching D-85748, Germany;

Iron silicide (FeSi) is a fascinating material that has attracted extensive research efforts for decades, notably revealing unusual temperature-dependent electronic and magnetic characteristics, as well as a close resemblance to the Kondo insulators whereby a coherent picture of intrinsic properties and underlying physics remains to be fully developed. For a better understanding of this narrow-gap semiconductor, we prepared and examined FeSi(110) single-crystal surfaces of high quality. Combined insights from low-temperature scanning tunneling microscopy and density functional theory calculations (DFT) indicate an unreconstructed surface termination presenting rows of Fe-Si pairs. Using high-resolution tunneling spectroscopy (STS), we identify a distinct asymmetric electronic gap in the sub-10 K regime on defect-free terraces. Moreover, the STS data reveal a residual density of states in the gap regime whereby two in-gap states are recognized. The principal origin of these features is rationalized with the help of the DFT-calculated band structure. The computational modeling of a (110)-oriented slab notably evidences the existence of interfacial intragap bands accounting for a markedly increased density of states around the Fermi level. These findings support and provide further insight into the emergence of surface metallicity in the low-temperature regime.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.2021203118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8092403PMC
April 2021

Intrinsic in-plane nodal chain and generalized quaternion charge protected nodal link in photonics.

Light Sci Appl 2021 Apr 15;10(1):83. Epub 2021 Apr 15.

Department of Physics, Hong Kong University of Science and Technology, Hong Kong, China.

Nodal lines are degeneracies formed by crossing bands in three-dimensional momentum space. Interestingly, these degenerate lines can chain together via touching points and manifest as nodal chains. These nodal chains are usually embedded in two orthogonal planes and protected by the corresponding mirror symmetries. Here, we propose and demonstrate an in-plane nodal chain in photonics, where all chained nodal lines coexist in a single mirror plane instead of two orthogonal ones. The chain point is stabilized by the intrinsic symmetry that is specific to electromagnetic waves at the Г point of zero frequency. By adding another mirror plane, we find a nodal ring that is constructed by two higher bands and links with the in-plane nodal chain. The nodal link in momentum space exhibits non-Abelian characteristics on a CT - invariant plane, where admissible transitions of the nodal link structure are determined by generalized quaternion charges. Through near-field scanning measurements of bi-anisotropic metamaterials, we experimentally mapped out the in-plane nodal chain and nodal link in such systems.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41377-021-00523-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8050084PMC
April 2021

Enhancement of Mechanical and Barrier Property of Hemicellulose Film via Crosslinking with Sodium Trimetaphosphate.

Polymers (Basel) 2021 Mar 17;13(6). Epub 2021 Mar 17.

College of Chemistry and Materials Engineering, Beijing Technology and Business University, Beijing 100048, China.

Hemicellulose is a kind of biopolymer with abundant resources and excellent biodegradability. Owing to its large number of polar hydroxyls, hemicellulose has a good barrier performance to nonpolar oxygen, making this biopolymer promising as food packaging material. Hydrophilic hydroxyls also make the polymer prone to water absorption, resulting in less satisfied strength especially under humid conditions. Thus, preparation of hemicellulose film with enhanced oxygen and water vapor barrier ability, as well as mechanical strength is still sought after. Herein, sodium trimetaphosphate (STMP) was used as esterification agent to form a crosslinked structure with hemicellulose through esterification reaction to render improved barrier performance by reducing the distance between molecular chains. The thus modified hemicellulose film achieved an oxygen permeability and water vapor permeability of 3.72 cm × μm × m × d × kPa and 2.85 × 10 × g × m × s × Pa, respectively, at the lowest esterification agent addition of 10%. The crosslinked structure also brought good mechanical and thermal properties, with the tensile strength reaching 30 MPa, which is 118% higher than that of the hemicellulose film. Preliminary test of its application in apple preservation showed that the barrier film obtained can effectively slow down the oxidation and dehydration of apples, showing the prospect of application in the field of food packaging.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3390/polym13060927DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8002615PMC
March 2021

A Review: Research Progress in Modification of Poly (Lactic Acid) by Lignin and Cellulose.

Polymers (Basel) 2021 Mar 3;13(5). Epub 2021 Mar 3.

College of Chemistry and Materials Engineering, Beijing Technology and Business University, Beijing 100048, China.

With the depletion of petroleum energy, the possibility of prices of petroleum-based materials increasing, and increased environmental awareness, biodegradable materials as a kind of green alternative have attracted more and more research attention. In this context, poly (lactic acid) has shown a unique combination of properties such as nontoxicity, biodegradability, biocompatibility, and good workability. However, examples of its known drawbacks include poor tensile strength, low elongation at break, poor thermal properties, and low crystallization rate. Lignocellulosic materials such as lignin and cellulose have excellent biodegradability and mechanical properties. Compounding such biomass components with poly (lactic acid) is expected to prepare green composite materials with improved properties of poly (lactic acid). This paper is aimed at summarizing the research progress of modification of poly (lactic acid) with lignin and cellulose made in in recent years, with emphasis on effects of lignin and cellulose on mechanical properties, thermal stability and crystallinity on poly (lactic acid) composite materials. Development of poly (lactic acid) composite materials in this respect is forecasted.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3390/polym13050776DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7959458PMC
March 2021

LncRNA AC105942.1 Downregulates hnRNPA2/B1 to Attenuate Vascular Smooth Muscle Cells Proliferation.

DNA Cell Biol 2021 May 30;40(5):652-661. Epub 2021 Mar 30.

Department of Laboratory Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China.

The abnormal proliferation of vascular smooth muscle cells (VSMCs) is crucial in the atherosclerosis. Although long noncoding RNAs (lncRNAs) are implicated in a variety of diseases, their roles in activation of VSMCs proliferation and vascular disorder diseases are not well understood. In addition, heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNPA2/B1) was reported to participate in lncRNAs-mediated function. Herein, we propose to investigate the role of lncRNA AC105942.1 and hnRNPA2/B1 in pathological VSMCs proliferation and the possible mechanisms . We have identified that lncRNA AC105942.1 was downregulated and hnRNPA2/B1 was upregulated in atherosclerotic plaques compared with normal artery tissues. Enhanced lncRNA AC105942.1 could noticeably inhibit Ang II-induced VSMCs proliferation. Further investigation suggested that lncRNA AC105942.1 could downregulate the expression of hnRNPA2/B1 and then regulate the level of CDK4 and p27. Taken together, our study indicated that lncRNA AC105942.1 downregulated hnRNPA2B1 to protect against the atherosclerosis by suppressing VSMCs proliferation. LncRNA AC105942.1 and hnRNPA2/B1 could represent potential therapeutic and diagnostic targets to atherosclerosis-related diseases.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1089/dna.2020.6451DOI Listing
May 2021

Biomarkers in Immunotherapy-Based Precision Treatments of Digestive System Tumors.

Front Oncol 2021 11;11:650481. Epub 2021 Mar 11.

Department of Abdominal Oncology, West China Medical School, West China Hospital, Sichuan University, Chengdu, China.

Immunotherapy, represented by immune checkpoint inhibitors (mainly referring to programmed death-1 (PD-1)/programmed death-ligand 1 (PD-L1) blockades), derives durable remission and survival benefits for multiple tumor types including digestive system tumors [gastric cancer (GC), colorectal cancer (CRC), and hepatocellular carcinoma (HCC)], particularly those with metastatic or recurrent lesions. Even so, not all patients would respond well to anti-programmed death-1/programmed death-ligand 1 agents (anti-PD-1/PD-L1) in gastrointestinal malignancies, suggesting the need for biomarkers to identify the responders and non-responders, as well as to predict the clinical outcomes. PD-L1expression has increasingly emerged as a potential biomarker when predicting the immunotherapy-based efficacy; but regrettably, PD-L1 alone is not sufficient to differentiate patients. Other molecules, such as tumor mutational burden (TMB), microsatellite instability (MSI), and circulating tumor DNA (ctDNA) as well, are involved in further explorations. Overall, there are not still no perfect or well-established biomarkers in immunotherapy for digestive system tumors at present as a result of the inherent limitations, especially for HCC. Standardizing and harmonizing the assessments of existing biomarkers, and meanwhile, switching to other novel biomarkers are presumably wise and feasible.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3389/fonc.2021.650481DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7991593PMC
March 2021

Construction of competitive endogenous RNA network reveals regulatory role of long non-coding RNAs in intracranial aneurysm.

BMC Neurosci 2021 03 9;22(1):15. Epub 2021 Mar 9.

Department of Neurosurgery, School of Medicine, Second Affiliated Hospital, Zhejiang University, NO.88 Jiefang Rd, Hangzhou, 310009, Zhejiang, China.

Background: Rupture of intracranial aneurysm (IA) is the main cause of devastating subarachnoid hemorrhage, which urges our understanding of the pathogenesis and regulatory mechanisms of IA. However, the regulatory roles of long non-coding RNAs (lncRNAs) in IA is less known.

Results: We processed the raw SRR files of 12 superficial temporal artery (STA) samples and 6 IA samples to count files. Then the differentially expressed (DE) mRNAs, miRNAs, and lncRNAs between STAs and IAs were identified. The enrichment analyses were performed using DEmRNAs. Next, a lncRNA-miRNA-mRNA regulatory network was constructed using integrated bioinformatics analysis. In summary, 341 DElncRNAs, 234 DEmiRNAs, and 2914 DEmRNAs between the STA and IA. The lncRNA-miRNA-mRNA regulatory network of IA contains 91 nodes and 146 edges. The subnetwork of hub lncRNA PVT1 was extracted. The expression level of PVT1 was positively correlated with a majority of the mRNAs in its subnetwork. Moreover, we found that several mRNAs (CCND1, HIF1A, E2F1, CDKN1A, VEGFA, COL1A1 and COL5A2) in the PVT1 subnetwork served as essential components in the PI3K-Akt signaling pathway, and that some of the non-coding RNAs (ncRNAs) (PVT1, HOTAIR, hsa-miR-17, hsa-miR-142, hsa-miR-383 and hsa-miR-193b) interacted with these mRNAs.

Conclusion: Our annotations noting ncRNA's role in the pathway may uncover novel regulatory mechanisms of ncRNAs and mRNAs in IA. These findings provide significant insights into the lncRNA regulatory network in IA.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12868-021-00622-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7945298PMC
March 2021

Momentum space toroidal moment in a photonic metamaterial.

Nat Commun 2021 Mar 19;12(1):1784. Epub 2021 Mar 19.

School of Physics and Astronomy, University of Birmingham, Birmingham, UK.

Berry curvature, the counterpart of the magnetic field in the momentum space, plays a vital role in the transport of electrons in condensed matter physics. It also lays the foundation for the emerging field of topological physics. In the three-dimensional systems, much attention has been paid to Weyl points, which serve as sources and drains of Berry curvature. Here, we demonstrate a toroidal moment of Berry curvature with flux approaching to π in judiciously engineered metamaterials. The Berry curvature exhibits a vortex-like configuration without any source and drain in the momentum space. Experimentally, the presence of Berry curvature toroid is confirmed by the observation of conical-frustum shaped domain-wall states at the interfaces formed by two metamaterials with opposite toroidal moments.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41467-021-22063-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7979886PMC
March 2021

Comprehensive analysis of the transcriptome-wide mA methylome in invasive malignant pleomorphic adenoma.

Cancer Cell Int 2021 Mar 2;21(1):142. Epub 2021 Mar 2.

Department of Oral Pathology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China.

Background: Invasive malignant pleomorphic adenoma (IMPA) is a highly invasive parotid gland tumor and lacks effective therapy. N6-Methyladenosine (mA) is the most prevalent post-transcriptional modification of mRNAs in eukaryotes and plays an important role in the pathogenesis of multiple tumors. However, the significance of mA-modified mRNAs in IMPA has not been elucidated to date. Hence, in this study, we attempted to profile the effect of IMPA in terms of mA methylation in mRNA.

Methods: Methylated RNA immunoprecipitation with next-generation sequencing (MeRIP-seq) and RNA sequencing (RNA-seq) were utilized to acquire the first transcriptome-wide profiling of the mA methylome map in IMPA followed by bioinformatics analysis.

Results: In this study, we obtained mA methylation maps of IMPA samples and normal adjacent tissues through MeRIP-seq. In total, 25,490 mA peaks associated with 13,735 genes were detected in the IMPA group, whereas 33,930 mA peaks associated with 18,063 genes were detected in the control group. Peaks were primarily enriched within coding regions and near stop codons with AAACC and GGAC motifs. Moreover, functional enrichment analysis demonstrated that mA-containing genes were significantly enriched in cancer and metabolism relevant pathways. Furthermore, we identified a relationship between the mA methylome and the RNA transcriptome, indicating a mechanism by which mA modulates gene expression.

Conclusions: Our study is the first to provide comprehensive and transcriptome-wide profiles to determine the potential roles played by mA methylation in IMPA. These results may open new avenues for in-depth research elucidating the mA topology of IMPA and the molecular mechanisms governing the formation and progression of IMPA.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12935-021-01839-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7923655PMC
March 2021

EDTA-K Improves the Detection Sensitivity of SARS-CoV-2 IgM and IgG Antibodies by Chelating Colloidal Gold in the Immunochromatographic Assay.

Int J Nanomedicine 2021 29;16:715-724. Epub 2021 Jan 29.

Department of Laboratory Medicine, Nanfang Hospital, Southern Medical University, Guangzhou 510515, People's Republic of China.

Objective: The coronavirus disease (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is now rapidly spreading globally. Serological tests are an important method to assist in the diagnosis of COVID-19, used for epidemiological investigations. In this study, we aimed to investigate the impact of different types of vacuum collection tubes on the detection of SARS-CoV-2 IgM and IgG antibodies, using the colloidal gold immunochromatographic assay (GICA).

Patients And Methods: A total of 112 patients with COVID-19 and 200 healthy control subjects with no infection were enrolled in this study. Their serum and plasma were collected into four different types of vacuum blood collection tubes. SARS-CoV-2 IgM and IgG specific antibodies in the plasma and serum were then detected by GICA and chemiluminescence assay (CA), respectively. In addition, the particle sizes of different colloidal gold solutions in the presence of different anticoagulants and coagulants were evaluated by both laser diffraction (Malvern) and confocal laser microscope, respectively.

Results: Our results revealed that anticoagulated plasma with EDTA-K improved the positive detection rate of SARS-CoV-2 IgM antibodies. Furthermore, our results shown that the detection results by GICA and CA were highly consistent, especially, the results of EDTA-K anticoagulated plasma detected by GICA was more consistent with CA results. We confirmed that EDTA-K could improve the detection sensitivity of SARS-CoV-2 IgG antibodies by chelating excessive colloidal gold compared with sodium citrate or lithium heparin, these methodologies did not appear to cause false positives. Colloidal gold particles could be chelated and aggregated by EDTA-K, but not by sodium citrate, lithium heparin and coagulants.

Conclusion: GICA is widely used to detect antibodies for the advantages of convenient, fast, low cost, suitable for screening large sample and require minimal equipment. In this study, we found that EDTA-K amplified the positive antibody signal by chelating colloidal gold and improved the detection sensitivity of SARS-CoV-2 IgM and IgG antibodies when using the GICA. Therefore, we suggested that EDTA-K anticoagulated plasma was more suitable for the detection of SARS-CoV-2 antibodies.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.2147/IJN.S281594DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7853433PMC
February 2021

Why are pandas so obsessed with horse manure?

Sci China Life Sci 2021 Mar 25;64(3):492-493. Epub 2021 Jan 25.

IUCN-CI Biodiversity Assessment Unit, Global Species Program, NW, 20009, Washington DC, USA.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11427-020-1882-yDOI Listing
March 2021

Extracellular Vesicles Derived From Yeasts Mediate Inflammatory Response in Macrophage Cells by Bioactive Protein Components.

Front Microbiol 2020 8;11:603183. Epub 2021 Jan 8.

Center for Clinical Laboratory, Zhujiang Hospital, Southern Medical University, Guangzhou, China.

Extracellular vesicles (EVs) loaded with proteins, nucleic acids, membrane lipids, and other virulence factors could participate in pathogenic processes in some fungi such as and . However, the specific characteristics of EVs derived from (TM) still have not been figured out yet. In the present study, it has been observed that TM-derived EVs were a heterogeneous group of nanosized membrane vesicles (30-300 nm) under nanoparticle tracking analysis and transmission electron microscopy. The DiI-labeled EVs could be taken up by RAW 264.7 macrophage cells. Incubation of EVs with macrophages would result in increased expression levels of reactive oxygen species, nitric oxide, and some inflammatory factors including interleukin-1β, interleukin-6, interleukin-10, and tumor necrosis factor. Furthermore, the expression of co-stimulatory molecules (CD80, CD86, and MHC-II) was also increased in macrophages stimulated with EVs. The level of inflammatory factors secreted by macrophages showed a significant decrease when EVs were hydrolyzed by protease, while that of DNA and RNA hydrolase treatment remained unchanged. Subsequently, some virulence factors in EVs including heat shock protein, mannoprotein 1, and peroxidase were determined by liquid chromatography-tandem mass spectrometry. Taken together, our results indicated that the TM-derived EVs could mediate inflammatory response and its protein would play a key role in regulating the function of RAW 264.7 macrophage cells.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3389/fmicb.2020.603183DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7819977PMC
January 2021

Progress and prospects of immune checkpoint inhibitors in advanced gastric cancer.

Future Oncol 2021 Apr 5;17(12):1553-1569. Epub 2021 Jan 5.

Department of Abdominal Oncology, West China Hospital, West China Medical School, Sichuan University, Chengdu, 610041, China.

Gastric cancer, a digestive malignancy, is the sixth most frequent cancer and the second leading cause of tumor-related deaths worldwide. The emergence and advancement of immunotherapeutic agents has brought significant survival benefits for patients with gastric cancer and increasingly challenged the conventional therapy pattern involving chemotherapy and target drugs. Furthermore, these breakthroughs have paved the way for immunotherapy, especially with immune checkpoint inhibitors, which act by blocking specific signaling pathways, in particular the CTLA4 pathway and the PD-1/PD-L1 pathway. In this review, we summarize the current trials of immune checkpoint inhibitors in GC and their predictive biomarkers, and discuss their present limitations.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.2217/fon-2020-0829DOI Listing
April 2021

Octreotide Reduces Pancreatic Islet Apoptosis and Improves Islet Transplantation Efficiency and .

J Biomed Nanotechnol 2020 Jul;16(7):1082-1101

The drug octreotide, a somatostatin analog, stimulates the cellular free radical scavenging system and inhibits the release of superoxide anions from monocytes. We hypothesized that octreotide also protects islet cell function and improves the survival of transplanted islets by ameliorating the adverse effects of hypoxia and reoxygenation on these cells, thus inhibiting apoptosis. To test this hypothesis, we experimentally induced hypoxia in islet cells in mouse insulinoma Min6 cells. Octreotide treatment mildly but significantly improved cell viability under normoxic and hypoxic conditions. Secreted vascular endothelial growth factor (VEGF) from the Min6 cells was downregulated after octreotide treatment during hypoxia. By contrast, the expression of hypoxia-inducible factor (HIF)-1 was upregulated after octreotide treatment under both normoxic and hypoxic conditions. Octreotide treatment also lowered the apoptotic rate of Min6 cells under hypoxic conditions . In a mouse transplant model, octreotide improved the post-transplantation efficacy and function of islet grafts. Expression of p53 and Bax in islet grafts was upregulated in the recipients treated with octreotide one day after islet transplantation, and the octreotide-treated group produced significantly less Bax than the control group on days 3 and 7 following transplantation. TUNEL assay further demonstrated a decrease in islet cell apoptosis in the octreotide group on days 1, 3, 7, and 14 after transplantation compared with that of the control group ( 0.05). No islet cell proliferation was found in the octreotide and control groups on days 1, 3, and 7 following transplantation. However, by day 14, the group treated with octreotide demonstrated significantly higher average cell proliferation rates than the controls did ( 0.05). Thus, octreotide decreased the apoptosis of islets under hypoxic conditions and enhanced the efficacy of islet transplantation . Octreotide has excellent potential for therapeutic applications in islet transplantation and merits further study.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1166/jbn.2020.2951DOI Listing
July 2020

Laser-Induced Interfacial Spallation for Controllable and Versatile Delamination of Flexible Electronics.

ACS Appl Mater Interfaces 2020 Nov 18. Epub 2020 Nov 18.

State Key Laboratory of Digital Manufacturing Equipment and Technology, Huazhong University of Science and Technology, Wuhan 430074, China.

The control of interface status is greatly critical to release large-area, ultrathin flexible electronics from the donor wafer to achieve mechanical flexibility. This paper discovers a laser-induced interfacial spallation process for controllable and versatile delamination of polyimide (PI) films from transparent substrates and makes a comprehensive mechanism study of the controllability of interfacial delamination after laser irradiations. Microscopic observations show that backside irradiations will result in the formation of nanocavities around the PI-glass interface, enabling a significant decrease in interface adhesion. Theoretical calculations indicate that gas products generated from thermal decomposition of PI will cause hydrodynamic spallation of molten PI around the interface. The controllable spallation behavior benefits the formation/elimination of fibrous microconnections between the PI film and glass substrate. A substantial regulation of interfacial micromorphologies can achieve precise control of interface adhesion, mass production of functional nanostructures, and nondestructive peeling of ultrathin flexible devices. The results could be useful for the fabrication of flexible electronics and biomimetic surfaces.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsami.0c18951DOI Listing
November 2020

Identification of Potential Core Genes Associated With the Progression of Stomach Adenocarcinoma Using Bioinformatic Analysis.

Front Genet 2020 22;11:517362. Epub 2020 Oct 22.

Department of General Surgery, Changhai Hospital, Second Military Medical University, Shanghai, China.

Purpose: Stomach adenocarcinoma (STAD) is one of the most frequently diagnosed cancer in the world with both high mortality and high metastatic capacity. Therefore, the present study aimed to investigate novel therapeutic targets and prognostic biomarkers that can be used for STAD treatment.

Materials And Methods: We acquired four original gene chip profiles, namely GSE13911, GSE19826, GSE54129, and GSE65801 from the Gene Expression Omnibus (GEO). The datasets included a total of 114 STAD tissues and 110 adjacent normal tissues. The GEO2R online tool and Venn diagram software were used to discriminate differentially expressed genes (DEGs). Gene ontology (GO) and Kyoto Encyclopedia of Gene and Genome (KEGG) enriched pathways were also performed for annotation and visualization with DEGs. The STRING online database was used to identify the functional interactions of DEGs. Subsequently, we selected the most significant DEGs to construct the protein-protein interaction (PPI) network and to reveal the core genes involved. Finally, the Kaplan-Meier Plotter online database and Gene Expression Profiling Interactive Analysis (GEPIA) were used to analyze the prognostic information of the core DEGs.

Results: A total of 114 DEGs (35 upregulated and 79 downregulated) were identified, which were abnormally expressed in the GEO datasets. GO analysis demonstrated that the majority of the upregulated DEGs were significantly enriched in collagen trimer, cell adhesion, and identical protein binding. The downregulated DEGs were involved in extracellular space, digestion, and inward rectifier potassium channel activity. Signaling pathway analysis indicated that upregulated DEGs were mainly enriched in receptor interaction, whereas downregulated DEGs were involved in gastric acid secretion. A total of 80 DEGs were screened into the PPI network complex, and one of the most important modules with a high degree was detected. Furthermore, 10 core genes were identified, namely COL1A1, COL1A2, FN1, COL5A2, BGN, COL6A3, COL12A1, THBS2, CDH11, and SERPINH1. Finally, the results of the prognostic information further demonstrated that all 10 core genes exhibited significantly higher expression in STAD tissues compared with that noted in normal tissues.

Conclusion: The multiple molecular mechanisms of these novel core genes in STAD are worthy of further investigation and may reveal novel therapeutic targets and biomarkers for STAD treatment.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3389/fgene.2020.517362DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7642829PMC
October 2020

Image-guided cochlear access by non-invasive registration: a cadaveric feasibility study.

Sci Rep 2020 10 27;10(1):18318. Epub 2020 Oct 27.

Department of Otorhinolaryngology - Head and Neck Surgery, Peking University Third Hospital, Peking University, No. 49 North Garden Road, Haidian District, Beijing, 100191, China.

Image-guided cochlear implant surgery is expected to reduce volume of mastoidectomy, accelerate recovery, and improve safety. The purpose of this study was to investigate the safety and effectiveness of image-guided cochlear implant surgery by a non-invasive registration method, in a cadaveric study. We developed a visual positioning frame that can utilize the maxillary dentition as a registration tool and completed the tunnels experiment on 5 cadaver specimens (8 cases in total). The accuracy of the entry point and the target point were 0.471 ± 0.276 mm and 0.671 ± 0.268 mm, respectively. The shortest distance from the margin of the tunnel to the facial nerve and the ossicular chain were 0.790 ± 0.709 mm and 1.960 ± 0.630 mm, respectively. All facial nerves, tympanic membranes, and ossicular chains were completely preserved. Using this approach, high accuracy was achieved in this preliminary study, suggesting that the non-invasive registration method can meet the accuracy requirements for cochlear implant surgery. Based on the above accuracy, we speculate that our method can also be applied to neurosurgery, orbitofacial surgery, lateral skull base surgery, and anterior skull base surgery with satisfactory accuracy.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-020-75530-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7591497PMC
October 2020

[Application of visible longwave radiation for inactivation of microorganisms].

Vestn Oftalmol 2020 ;136(6):42-49

Research Institute of Eye Diseases, Moscow, Russia.

Purpose: To perform a comparative assessment of the bactericidal and fungicidal effects of various parts of the radiation spectrum (Ultraviolet A, red, green and blue).

Material And Methods: The study included strains of the most clinically significant microorganisms, which are the most common causes of purulent keratitis - , and fungi . After populating the surface of Petri dishes uniformly with microorganisms of each culture, on four out of the five specimens the central zone of the surface with a diameter of 1 cm was irradiated with light of different spectrum - from ultraviolet to red, with a total radiation energy density of 5.4 J/cm. One specimen remained as the control subject. After irradiation, scanning electron microscopy with lanthanides contrasting (SEMLC) was used to evaluate the total metabolic activity, the activity of the efflux systems and the morphological characteristics of the microorganisms.

Results: The damaging effect of visible spectrum light and UVA radiation on , and cultures was proved by SEMLC. Green spectrum emission with a wavelength of 500 nm had the highest antimicrobial activity. It was manifested by a decrease in the overall level of metabolic activity (from 40-63 c.u. to 26-37 c.u. ( (<0.01), (<0.01) and (<0.05)), as well as a 2-fold increase in the proportion of cells with active efflux systems.

Conclusion: SEMLC allows evaluation of parameters of the microorganisms` state: morphological (form and size) and functional (general metabolic activity, activation of efflux systems). Investigation of , and cultures using SEMLC demonstrated the antimicrobial activity of green spectrum radiation of 500 nm wavelength. This will serve as a basis for further research and development of a method of treating infectious keratitis using green light.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.17116/oftalma202013606142DOI Listing
October 2020

TM4SF19 aggravates LPS-induced attenuation of vascular endothelial cell adherens junctions by suppressing VE-cadherin expression.

Biochem Biophys Res Commun 2020 12 12;533(4):1204-1211. Epub 2020 Oct 12.

Laboratory Medicine Center, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China; Laboratory Medicine Center, Zhujiang Hospital, Southern Medical University, Guangzhou, 510515, China. Electronic address:

Atherosclerosis is a chronic vascular inflammatory disease that initially starts from an arterial intima lesion and endothelial barrier dysfunction. The purpose of this study was to investigate the role of TM4SF19, a recently identified member of the transmembrane 4L six superfamily, in vascular endothelial cell adherens junctions. We found TM4SF19 expression was significantly increased in atherosclerotic plaques and sera of patients with coronary heart disease (CHD) compared with healthy people by immunohistochemistry and ELISA. In vitro, human umbilical vein endothelial cells (HUVECs) were stimulated by lipopolysaccharides (LPS). TM4SF19 and VE-cadherin expression as well as cell adherens junctions were assessed. Additionally, LPS could upregulate TM4SF19 expression and downregulate VE-cadherin expression in HUVECs in a concentration dependent manner. Overexpression of TM4SF19 substantially aggravated LPS-induced reduction of VE-cadherin expression and attenuation of vascular endothelial cell adherens junctions. However, both the decreased VE-cadherin expression and weakened cell adherens junctions induced by LPS could be dramatically reversed when the expression of TM4SF19 was depressed. This study is the first to reveal the effect of TM4SF19 on endothelial cell adherens junctions. Meanwhile, our results also provide novel therapeutic strategies for atherosclerotic diseases.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2020.08.078DOI Listing
December 2020

GNG5 is an unfavourable independent prognostic indicator of gliomas.

J Cell Mol Med 2020 11 30;24(21):12873-12878. Epub 2020 Sep 30.

Department of Neurosurgery, Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Gliomas are the most common primary brain tumours, and glioblastomas (GBMs) are subgrouped into four distinct molecular subtypes. This study aimed to identify the potential gene related to glioma progression. Weighted gene co-expression network analysis (WGCNA) was used to explore the related gene. Correlation, ROC, survival and Cox regression analyses were performed. Blue module was strongly associated with WHO grade (r = .65, P = 1e-19). GNG5 in gliomas was overexpressed compared with normal samples and associated with clinicopathologic characteristics. GNG5 was frequent in Mesenchymal subtype and lowly expressed in Proneural subtype of GBMs. Survival and Cox regression analyses showed that glioma patients with GNG5 overexpression had shorter survival time, and GNG5 was an independent prognostic indicator of overall survival. Overall, GNG5 expression is closely associated with clinicopathologic characteristics and is an independent prognostic indicator for glioma patients, as well as a promising subtype-associated biomarker in molecular classification of gliomas.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1111/jcmm.15923DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7686969PMC
November 2020

Barrier Film of Etherified Hemicellulose from Single-Step Synthesis.

Polymers (Basel) 2020 Sep 25;12(10). Epub 2020 Sep 25.

College of Chemistry and Materials Engineering, Beijing Technology and Business University, Beijing 100048, China.

Hemicellulose with good biodegradability and low oxygen permeability shows great potential in food packaging. However, its strong hydrophilicity leads to its poor moisture resistance, which hinders its wider application. In this paper, a near-hydrophobic hemicellulose was obtained by using single-step synthesis from poplar powder via etherification modification with epoxy chloropropane. This proposed approach has the advantage of avoiding the destruction of hemicellulose structure by secondary alkali-hydrolysis, which was what usually occurred in traditional etherification procedures. The feasibility of using epoxy chloropropane as an alkylation reagent to etherify hemicellulose was confirmed, and the reaction mechanism was elucidated. Contact angle test, thermogravimetric analysis, oxygen transmittance test, and infrared spectrum analysis showed that the barrier property and thermal stability of etherified hemicellulose films have been significantly improved. At an epoxy chloropropane/wood powder ratio (volume/weight) of 2/3 (mL/g), the epoxy hemicellulose films contained the most epoxy groups and displayed the best performance, i.e., tensile strength of 14.6 MPa, surface contact angle of 71.7° and oxygen transmission coefficient of 1.9 (cm·µm)/(m·d·kPa), showing great promise as barrier film in food-packaging.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3390/polym12102199DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7599748PMC
September 2020

Long noncoding RNA ZNF800 suppresses proliferation and migration of vascular smooth muscle cells by upregulating PTEN and inhibiting AKT/mTOR/HIF-1α signaling.

Atherosclerosis 2020 11 14;312:43-53. Epub 2020 Sep 14.

Laboratory Medicine Center, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China. Electronic address:

Background And Aims: Long noncoding RNAs (lncRNAs) have recently been implicated in many biological and disease processes, but the exact mechanism of their involvement in atherosclerosis is unclear. The aberrant proliferation and migration of vascular smooth muscle cells (VSMCs) is a major contributor to the development of atherosclerotic lesions. This study aimed to investigate the potential effects of lncRNA ZNF800, a previously uncharacterized lncRNA, on VSMC proliferation and migration.

Methods: The expression of lncRNA ZNF800 in atherosclerotic plaque tissues was detected using reverse transcription-quantitative PCR (RT-qPCR), while the role and mechanism of lncRNA ZNF800 in proliferation and migration of VSMCs were investigated by CCK8 assay, transwell assay, scratch wound assay, RT-qPCR and Western blot.

Results: We found that lncRNA ZNF800 was significantly more abundant in atherosclerotic plaque tissues, and substantially suppressed the proliferation and migration of VSMCs. LncRNA ZNF800 had no effect on phosphatase and tensin homolog deleted on chromosome 10 (PTEN) mRNA expression but dramatically increased the levels of PTEN protein. Enhanced lncRNA ZNF800 expression inhibited the activity of the AKT/mTOR/HIF-1α signaling pathway, downregulated the expression of vascular endothelial growth factor α (VEGF-α) and matrix metalloproteinase 1 (MMP1), and suppressed VSMC proliferation and migration. These inhibitory effects of lncRNA ZNF800 were abolished by knockdown of PTEN. The inhibitory effects of lncRNA ZNF800 on cell proliferation and migration and the expression of VEGF-α and MMP1 were exacerbated by HIF-1α knockdown in VSMCs.

Conclusions: These findings demonstrated that lncRNA ZNF800 suppressed VSMC proliferation and migration by interacting with PTEN through a mechanism involving AKT/mTOR/HIF-1α signaling. Therefore, it may play a key atheroprotective role and represent a potential therapeutic target for atherosclerosis-related diseases.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.atherosclerosis.2020.09.007DOI Listing
November 2020

Assembly-Induced Strong Circularly Polarized Luminescence of Spirocyclic Chiral Silver(I) Clusters.

Angew Chem Int Ed Engl 2021 Jan 16;60(3):1535-1539. Epub 2020 Nov 16.

Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing, 100084, China.

Spirocyclic Ag clusters, as a new form of intrinsically chiral metal clusters, were constructed through vertex-sharing of two in-situ-generated heteroaryl diide-centered metal rings. Such core-peripheral type clusters exhibit versatile photoluminescent and chiroptical behavior under different aggregation conditions. In contrast to a ligand-based fluorescence emission in a diluted solution of the clusters, a solvent polarity-caused assembly gives rise to new cluster-based phosphorous luminescence owing to radiative mode switching and aggregation-induced emission. Assembly of cluster enantiomers leads to micrometer-long helical nanofibers, whose handedness is determined by absolute configuration of individual spirocyclic clusters. Benefiting from exciton couplings of helical arrangements of chelating ligands at molecular and microscopic levels, the assembled film of cluster enantiomers exhibits circularly polarized luminescence with a high anisotropy factor (0.16).
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1002/anie.202008765DOI Listing
January 2021

Cell Senescence: A Nonnegligible Cell State under Survival Stress in Pathology of Intervertebral Disc Degeneration.

Oxid Med Cell Longev 2020 31;2020:9503562. Epub 2020 Aug 31.

Department of Orthopedics Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, 310009 Hangzhou, Zhejiang, China.

The intervertebral disc degeneration (IDD) with increasing aging mainly manifests as low back pain (LBP) accompanied with a loss of physical ability. These pathological processes can be preliminarily interpreted as a series of changes at cellular level. In addition to cell death, disc cells enter into the stagnation with dysfunction and deteriorate tissue microenvironment in degenerative discs, which is recognized as cell senescence. During aging, many intrinsic and extrinsic factors have been proved to have strong connections with these cellular senescence phenomena. Growing evidences of these connections require us to gather up critical cues from potential risk factors to pathogenesis and relative interventions for retarding cell senescence and attenuating degenerative changes. In this paper, we try to clarify another important cell state apart from cell death in IDD and discuss senescence-associated changes in cells and extracellular microenvironment. Then, we emphasize the role of oxidative stress and epigenomic perturbations in linking risk factors to cell senescence in the onset of IDD. Further, we summarize the current interventions targeting senescent cells that may exert the benefits of antidegeneration in IDD.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1155/2020/9503562DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7479476PMC
May 2021