Dr. Bhesh Sharma, PhD - St Jude Children's Research Hospital - PostDoc

Dr. Bhesh Sharma

PhD

St Jude Children's Research Hospital

PostDoc

Memphis, Tennessee | United States

Main Specialties: Allergy & Immunology, Biology, Oncology

Dr. Bhesh Sharma, PhD - St Jude Children's Research Hospital - PostDoc

Dr. Bhesh Sharma

PhD

Introduction

Primary Affiliation: St Jude Children's Research Hospital - Memphis, Tennessee , United States

Specialties:

Publications

15Publications

534Reads

2Profile Views

83PubMed Central Citations

Innate immune adaptor MyD88 deficiency prevents skin inflammation in SHARPIN-deficient mice.

Cell Death Differ 2019 03 23;26(4):741-750. Epub 2018 Jul 23.

Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.

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http://dx.doi.org/10.1038/s41418-018-0159-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460383PMC
March 2019
63 Reads
8.184 Impact Factor

IRF8 Regulates Transcription of Naips for NLRC4 Inflammasome Activation.

Cell 2018 05 22;173(4):920-933.e13. Epub 2018 Mar 22.

Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2018.02.055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5935577PMC
May 2018
26 Reads
32.242 Impact Factor

IL-1β and Caspase-1 Drive Autoinflammatory Disease Independently of IL-1α or Caspase-8 in a Mouse Model of Familial Mediterranean Fever.

Am J Pathol 2017 Feb 18;187(2):236-244. Epub 2016 Dec 18.

Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2016.10.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389372PMC
February 2017
39 Reads
6 Citations
4.591 Impact Factor

A Comprehensive Review on Chemical Profiling of Nelumbo Nucifera: Potential for Drug Development.

Phytother Res 2017 Jan 26;31(1):3-26. Epub 2016 Sep 26.

Department of Oriental Medicine Resources, College of Natural Sciences, Mokpo National University, 61, Muan-gun, Jeonnam, 534-729, Korea.

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http://dx.doi.org/10.1002/ptr.5732DOI Listing
January 2017
109 Reads
7 Citations
2.400 Impact Factor

NLRC3 is an inhibitory sensor of PI3K-mTOR pathways in cancer.

Nature 2016 Dec 12;540(7634):583-587. Epub 2016 Dec 12.

Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.

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http://dx.doi.org/10.1038/nature20597DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5468516PMC
December 2016
74 Reads
29 Citations
42.351 Impact Factor

Distinct role of IL-1β in instigating disease in Sharpin mice.

Sci Rep 2016 11 28;6:36634. Epub 2016 Nov 28.

Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.

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http://dx.doi.org/10.1038/srep36634DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5125001PMC
November 2016
27 Reads
1 Citation
5.080 Impact Factor

Alkaloid rich fraction from Nelumbo nucifera targets VSMC proliferation and migration to suppress restenosis in balloon-injured rat carotid artery.

Atherosclerosis 2016 May 21;248:179-89. Epub 2016 Mar 21.

Department of Oriental Medicine Resources, Mokpo National University, Muan-gun, Jeonnam 534-729, Republic of Korea. Electronic address:

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http://dx.doi.org/10.1016/j.atherosclerosis.2016.03.020DOI Listing
May 2016
24 Reads
6 Citations
3.994 Impact Factor

Anti-Obesity Effects of the Mixture of Eriobotrya japonica and Nelumbo nucifera in Adipocytes and High-Fat Diet-Induced Obese Mice.

Am J Chin Med 2015 1;43(4):681-94. Epub 2015 Jul 1.

Department of Oriental Medicine Resources and Institute of Korean Medicine Industry, Mokpo National University, Jeonnam 534-729, Republic of Korea.

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http://dx.doi.org/10.1142/S0192415X15500421DOI Listing
April 2016
57 Reads
2 Citations
2.625 Impact Factor

Lespedeza davurica (Lax.) Schindl. extract protects against cytokine-induced β-cell damage and streptozotocin-induced diabetes.

Biomed Res Int 2015 22;2015:169256. Epub 2015 Feb 22.

Department of Oriental Medicine Resources and Institute of Korean Medicine Industry, College of Natural Science, Mokpo National University, 1666 Youngsan-ro, Muan-gun, Jeonnam 534-729, Republic of Korea ; Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97331, USA.

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http://dx.doi.org/10.1155/2015/169256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4352516PMC
January 2016
5 Reads
4 Citations

Caulerpa lentillifera extract ameliorates insulin resistance and regulates glucose metabolism in C57BL/KsJ-db/db mice via PI3K/AKT signaling pathway in myocytes.

J Transl Med 2015 Feb 15;13:62. Epub 2015 Feb 15.

Department of Oriental Medicine Resources and Institute of Korean Medicine Industry, Mokpo National University, 1666 Youngsan-ro, Muan-gun, 534-729, Jeonnam, Republic of Korea.

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http://dx.doi.org/10.1186/s12967-015-0412-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4350654PMC
February 2015
36 Reads
10 Citations
3.930 Impact Factor

Lespedeza davurica (Lax.) Schindl. Extract Protects against Cytokine-Induced β-Cell Damage and Streptozotocin-Induced Diabetes

BioMed Research International

Lespedeza has been used for the management of diabetes in folklore medicine. The purpose of this study is to investigate the protective effects of the methanol extract of Lespedeza davurica (LD) on cytokine-induced β-cell damage and streptozotocin- (STZ-) induced diabetes. RINm5F cells were treated with interleukin- (IL-) 1β and interferon- (IFN-) γ to induce pancreatic β-cell damage. The exposure of LD extract significantly decreased cell death, nitric oxide (NO) production, nitric oxide synthase (iNOS) expression, and nucleus factor-kappa B (NF-κB) p65 activation. Antidiabetic effects of LD extract were observed by oral glucose tolerance test (OGTT) in normal rats and by checking the biochemical, physiological, and histopathological parameters in STZ-induced diabetic rats. In OGTT, glucose clearance levels improved by oral treatment of LD extract. The water intake, urine volume, blood glucose, and serum TG, TC, TBARS, and DPP-IV levels were significantly decreased, and liver glycogen content was significantly increased by treatment of LD extract (250 mg/kg BW) in STZ-induced diabetic rats. Also, insulin immunoreactivity of the pancreases was increased in LD extract administrated rats compared with diabetic control rats. These results indicate that LD extract may protect pancreatic β-cell damage and regulate the blood glucose in STZ-induced diabetic rats.

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December 2014
12 Reads

Anti-diabetic effects of Caulerpa lentillifera: stimulation of insulin secretion in pancreatic β-cells and enhancement of glucose uptake in adipocytes.

Asian Pac J Trop Biomed 2014 Jul;4(7):575-80

Department of Oriental Medicine Resources and Institute of Korean Medicine Industry, Mokpo National University, Jeonnam 534-729, Republic of Korea.

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http://dx.doi.org/10.12980/APJTB.4.2014APJTB-2014-0091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4032834PMC
July 2014
36 Reads
3 Citations

Inhibition of preadipocyte differentiation and lipid accumulation by 7-O-galloyl-d-sedoheptulose treatment in 3T3-L1 adipocytes

Biomedicine & Preventive Nutrition

In this study, we investigated the effect of 7-O-galloyl-d-sedoheptulose (GS) on adipocyte differentiation in 3T3-L1 cells. GS significantly suppressed 3T3-L1 differentiation. The activation of adenosine monophosphate-activated protein kinase (AMPK) was demonstrated by measuring phosphorylation. In addition, GS down-regulated the adipogenesis-related protein expression of the sterol regulatory element-binding protein 1c. GS significantly reduced the protein expression of the peroxisome proliferator-activated receptor γ and of the CCAAT/enhancer-binding protein α, two key transcription factors in adipogenesis. These findings indicate that GS exerts anti-adipogenic activity via AMPK activation and may act to prevent obesity.

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May 2013
9 Reads

Role of reactive oxygen species in transforming growth factor-beta1-induced extracellular matrix accumulation in renal tubular epithelial cells.

Transplant Proc 2012 Apr;44(3):625-8

Department of Oriental Medicine Resources, Mokpo National University, Jeonnam, Korea.

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http://dx.doi.org/10.1016/j.transproceed.2011.12.054DOI Listing
April 2012
7 Reads
13 Citations

Top co-authors

Rajendra Karki
Rajendra Karki

Mokpo National University

5
Dong Young Rhyu
Dong Young Rhyu

Mokpo National University

5
Qifan Zhu
Qifan Zhu

University of Tennessee Health Science Center

3
Peter Vogel
Peter Vogel

St. Jude Children's Research Hospital

2
Deepak Adhikari
Deepak Adhikari

University of Gothenburg

2
Ein Lee
Ein Lee

St. Jude Children's Research Hospital

2
Prajwal Gurung
Prajwal Gurung

University of Iowa

2
Min Suk Kim
Min Suk Kim

Korea Cancer Center Hospital

1
Keshav Raj Paudel
Keshav Raj Paudel

University of Technology Sydney

1